Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| in vivo analysis of staphylococcus aureus infected mice reveals differential temporal and spatial expression patterns of fhud2. | staphylococcus aureus is an opportunistic human pathogen and a major cause of invasive infections such as bacteremia, endocarditis, pneumonia and wound infections. fhud2 is a staphylococcal lipoprotein involved in the uptake of iron-hydroxymate and is under the control of the iron uptake regulator fur. the protein is part of an investigational multi-component vaccine formulation that has shown protective efficacy in several murine models of infection. even though fhud2 expression was shown to be ... | 2017 | 28784927 |
| a spinal infection with staphylococcus pseudintermedius. | we present a case of a 60-year-old woman with an invasive spinal infection with staphylococcus pseudintermedius associated with a 15-year-old spinal fixation device and epidemiological contact with dogs. it was confirmed on blood culture and culture from pus from the epidural abscess and successfully treated using similar treatment as for a staphylococcus aureus infection - 6 weeks of intravenous flucloxacillin 2 g four times daily with a 6 week follow-on course of oral clindamycin 450 mg three ... | 2017 | 28784907 |
| diagnostic approach in persistent staphylococcus aureus bacteraemia. | staphylococcus aureus is the leading cause of bacteraemia and can lead to complicated infections that may be difficult to diagnose and hence lead to higher morbidity. failure to identify such could lead to severe complications or relapsing bacteraemia due to inadequate treatment. the authors report a patient presenting with methicillin-resistant s. aureus (mrsa) bacteraemia and septic arthritis, who developed a complicated infection with multiple metastasis and persistent bacteraemia despite ade ... | 2017 | 28784899 |
| impact of exposure of methicillin-resistant staphylococcus aureus to polyhexanide in vitro and in vivo. | staphylococcus aureus (mrsa) resistant to decolonization agents such as mupirocin and chlorhexidine increase the need to develop alternative decolonization molecules. the absence of reported adverse reactions and bacterial resistance to polyhexanide makes it an excellent choice as topical antiseptic. in the present study we evaluated the in vitro and in vivo capacity to generate strains with reduced polyhexanide susceptibility and cross-resistance with chlorhexidine and/or antibiotics currently ... | 2017 | 28784678 |
| characterization of the tertiary structure of the peptidoglycan of enterococcus faecalis. | solid-state nmr spectra of whole cells and isolated cell walls of enterococcus faecalis grown in media containing combinations of (13)c and (15)n specific labels in d- and l-alanine and l-lysine (in the presence of an alanine racemase inhibitor alaphosphin) have been used to determine the composition and architecture of the cell-wall peptidoglycan. the compositional variables include the concentrations of (i) peptidoglycan stems without bridges, (ii) d-alanylated wall teichoic acid, (iii) cross- ... | 2017 | 28784459 |
| ecofriendly synthesis of silver and gold nanoparticles by euphrasia officinalis leaf extract and its biomedical applications. | biogenic synthesis of silver (agnps) and gold nanoparticles (aunps) using aqueous extract of euphrasia officinalis has been reported. stable agnps and aunps were formed on adding aqueous solutions of silver nitrate and chloroauric acid with e. officinalis leaf extract, in 19 min and 2 min, respectively. the synthesis method used in present study was simple, reliable, rapid, cost effective and ecofriendly. the synthesized nanoparticles were characterized with field emission transmission electron ... | 2017 | 28784039 |
| a tslp-complement axis mediates neutrophil killing of methicillin-resistant staphylococcus aureus. | community-acquired staphylococcus aureus infections often present as serious skin infections in otherwise healthy individuals and have become a worldwide epidemic problem fueled by the emergence of strains with antibiotic resistance, such as methicillin-resistant s. aureus (mrsa). the cytokine thymic stromal lymphopoietin (tslp) is highly expressed in the skin and in other barrier surfaces and plays a deleterious role by promoting t helper cell type 2 (th2) responses during allergic diseases; ho ... | 2016 | 28783679 |
| nanoscale silver depositions inhibit microbial colonization and improve biocompatibility of titanium abutments. | although titanium dental implants are biocompatible, exhibit excellent corrosion resistance and high mechanical resistance, the material fails in providing resistance to infection because it exhibits poor antimicrobial activity. to address these issues, we deposited silver onto titanium abutments (grade 5 titanium discs) using direct current (dc) sputtering and assessed the antimicrobial activity and biocompatibility of the modified implant material. atomic absorption spectrometry and x-ray phot ... | 2017 | 28783506 |
| characterization of livestock-associated methicillin-resistant staphylococcus aureus cc398 and mecc-positive cc130 from zoo animals in the united kingdom. | little is known about the characteristics and diseases associated with methicillin-resistant staphylococcus aureus (mrsa) in nondomestic animals. four presumptive mrsa isolates, obtained from clinical (n = 3) and surveillance specimens (n = 1) from dwarf (helogale parvula) and yellow mongooses (cynictis penicillata) from a united kingdom zoo, were analyzed by pcr for detection of meca and mecc-mediated methicillin resistance, and virulence genes. isolates were genotyped by multilocus sequence ty ... | 2017 | 28783429 |
| diagnosis and management of panton-valentine leukocidin toxin associated staphylococcus aureus infection: an update. | the incidence of invasive staphylococcus aureus (sa) infection has increased in the past decade and is associated with poor outcomes and high mortality rates. of all the virulence factors, panton-valentine leukocidin (pvl) has received the greatest attention. pvl producing sa strains are more likely to produce severe skin and soft tissue infections (sstis) and necrotizing pneumonia. this review focuses on the current evidence on pvl-sa virulence, epidemiology, clinical disease and treatment with ... | 2017 | 28783418 |
| interaction between various apple procyanidin and staphylococcal enterotoxin a and their inhibitory effects on toxin activity. | in this study, we investigated the interaction between apple polyphenols (ap; mainly consisting of procyanidin (pc) from an apple) and staphylococcal enterotoxin a (sea), and the inhibitory effects of ap on sea activity. according to the degree of polymerization, in particularly highly polymerized pc (more than pentamer) strongly interacted with sea. the binding affinity of ap with sea molecules was determined using biacore analysis. ap reacted with sea immobilized on a biacore sensor chip. afte ... | 2017 | 28783092 |
| nbeal2 is required for neutrophil and nk cell function and pathogen defense. | mutations in the human nbeal2 gene cause gray platelet syndrome (gps), a bleeding diathesis characterized by a lack of α granules in platelets. the functions of the nbeal2 protein have not been explored outside platelet biology, but there are reports of increased frequency of infection and abnormal neutrophil morphology in patients with gps. we therefore investigated the role of nbeal2 in immunity by analyzing the phenotype of nbeal2-deficient mice. we found profound abnormalities in the nbeal2- ... | 2017 | 28783043 |
| first-in-class inhibitor of ribosomal rna synthesis with antimicrobial activity against staphylococcus aureus. | we report the discovery of the first bacterial ribosomal rna (rrna) synthesis inhibitor that has specific antimicrobial activity against methicillin-resistant staphylococcus aureus (mrsa). a pharmacophore model was constructed on the basis of the protein-protein interaction between essential bacterial rrna transcription factors nusb and nuse and employed for an in silico screen to identify potential leads. one compound, (e)-2-{[(3-ethynylphenyl)imino]methyl}-4-nitrophenol (mc4), demonstrated ant ... | 2017 | 28782938 |
| new insights into antibiofilm effect of a nanosized zno coating against the pathogenic methicillin resistant staphylococcus aureus. | zno nanoparticles (nps) are arising as promising novel antibiotics toward device-related infections. the surface functionalization of zn, a novel resorbable biomaterial, with zno nps could present an effective solution to overcome such a threat. in this sense, the antibacterial and antibiofilm activity of nano- and microsized zno coatings was studied against clinically relevant bacteria, methicillin resistant staphylococcus aureus (mrsa). the bacterial viability of planktonic and biofilm cells t ... | 2017 | 28782933 |
| in vitro activity of alpha-viniferin isolated from the roots of carex humilis against mycobacterium tuberculosis. | this study explores the antitubercular activity of α-viniferin, a bioactive phytochemical compound obtained from carex humilis. α-viniferin was active against both drug-susceptible and -resistant strains of mycobacterium tuberculosis at mic50s of 4.6 μm in culture broth medium and mic50s of 2.3-4.6 μm inside macrophages and pneumocytes. in combination with streptomycin and ethambutol, α-viniferin exhibited an additive effect and partial synergy, respectively, against m. tuberculosis h37rv. α-vin ... | 2017 | 28782713 |
| emergence of dalbavancin non-susceptible, vancomycin-intermediate staphylococcus aureus (visa) after treatment of mrsa central line-associated bloodstream infection with a dalbavancin- and vancomycin-containing regimen. | dalbavancin is a long-acting lipoglycopeptide with activity against gram-positives, including methicillin-resistant staphylococcus aureus(mrsa). the potential for lipoglycopeptides, with half-lives greater than one-week, to select for resistance is unknown. here we explore a case of mrsa central line-associated blood stream infection in which dalbavancin and vancomycin non-susceptibility emerged in a urine isolate collected after the patient was treated with vancomycin and dalbavancin sequential ... | 2017 | 28782651 |
| genomic epidemiology of methicillin-susceptible staphylococcus aureus across colonisation and skin and soft tissue infection. | staphylococcus aureus skin and soft tissue infection (sa-ssti) places a significant burden on healthcare systems. new zealand has a high incidence of sa-ssti, and here most morbidity is caused by a polyclonal methicillin-susceptible (mssa) bacterial population. however, mssa also colonise asymptomatically the cornified epithelia of approximately 20% of the population, and their divide between commensalism and pathogenicity is poorly understood. we aimed to see whether mssa are genetically differ ... | 2017 | 28782565 |
| structure, dissolution behavior, cytocompatibility, and antibacterial activity of silver-containing calcium phosphate invert glasses. | novel cao-p2 o5 -nb2 o5 -ag2 o invert glasses with substitution ag2 o for nb2 o5 were successfully prepared using a melt-quenching method. ag2 o in the glasses act as a network modifier oxide, playing the same role as na2 o, which breaks the phosphate chains. analysis of the ultraviolet-visible absorption spectra of the glasses showed that the glass matrix contained ionic silver species and silver nanoparticles. approximately 0.05 mm of nb(5+) ions released from the glasses, which would be expec ... | 2017 | 28782272 |
| electrophoretic deposition of mgo nanoparticles imparts antibacterial properties to poly-l-lactic acid for orthopedic applications. | bacterial infection of implanted biomaterials is a serious problem that increases health care costs and negatively affects a considerable fraction of orthopedic procedures. in this field, magnesium oxide nanoparticles (mgo nps) have emerged as a promising material to combat bacterial infection while maintaining or improving bone cell functions. here, mgo nps were electrophoretically deposited onto poly-l-lactic acid (plla) sheets to achieve a coating of highly exposed mgo nps that directly influ ... | 2017 | 28782240 |
| staphylococcal biofilm gene expression on biomaterials - a methodological study. | the combination of increased healthcare access, universal aging, and infallible therapy demands, synergistically drive the need for the development of biomaterial technologies that mitigate the challenge of biomaterial-associated infections (bai). staphylococcus epidermidis and staphylococcus aureus account for the majority of bai due to their ability to accumulate in adherent multilayered biofilm. this investigation details the development of gene expression assays to evaluate the genetic proce ... | 2017 | 28782178 |
| rapid antibiotic sensitivity testing in microwell arrays. | the widespread bacterial resistance to a broad range of antibiotics necessitates rapid antibiotic susceptibility testing before effective treatment could start in the clinic. among resistant bacteria, staphylococcus aureus is one of the most important, and methicillin-resistant (mrsa) strains are a common cause of life threatening infections. however, standard susceptibility testing for s. aureus is time consuming and thus the start of effective antibiotic treatment is often delayed. to circumve ... | 2017 | 28781994 |
| thermo-and ph-sensitive hydrogel membranes composed of poly(n-isopropylacrylamide)-hyaluronan for biomedical applications: influence of hyaluronan incorporation on the membrane properties. | interpenetrating hydrogel membranes consisting of ph-sensitive hyaluronan (ha) and thermo-sensitive poly(n-isopropylacrylamide) (pnipaam) were synthesized using redox polymerization, followed by n,n-methylenebisacrylamide (bis) and epichlorohydrin (epi) were added as chemical crosslinkers. the interaction between membrane compositions has been characterized by ftir spectroscopy and discussed intensively. the result indicates that ha incorporation in membranes increase the gel fraction, swelling ... | 2017 | 28780413 |
| prevalence and characterization of methicillin-resistant staphylococcus aureus carrying meca or mecc and methicillin-susceptible staphylococcus aureus in dairy sheep farms in central italy. | between january and may 2012, a total of 286 bulk tank milk samples from dairy sheep farms located in central italy were tested for the presence of staphylococcus aureus. one hundred fifty-three samples were positive for s. aureus (53.5%), with an average count of 2.53 log cfu/ml. a total of 679 s. aureus colonies were screened for methicillin resistance by the cefoxitin disk diffusion test, and 104 selected cefoxitin-susceptible isolates were also tested for their susceptibility to other antimi ... | 2017 | 28780098 |
| within-herd prevalence thresholds for herd-level detection of mastitis pathogens using multiplex real-time pcr in bulk tank milk samples. | the objective of the study was to assess the value of quantitative multiplex real-time pcr examination of bulk tank milk samples for bovine mastitis pathogens as a tool for herd level diagnosis. using a logistic regression model, this study is aimed at calculating the threshold level of the apparent within-herd prevalence as determined by quarter milk sample cultivation of all lactating cows, thus allowing the detection of a herd positive for a specific pathogen within certain probability levels ... | 2017 | 28780090 |
| physakengoses k-q, seven new sucrose esters from physalis alkekengi var. franchetii. | seven sucrose esters, physakengoses k-q (1-7) were isolated from the aerial parts of physalis alkekengi var. franchetii. their structures were elucidated on the basis of extensive spectroscopic analyses and chemical methods. these new compounds were tested for their antimicrobial abilities against staphylococcus aureus, bacillus subtilis, pseudomonas aeruginosa and escherichia coli. among the isolated sucrose esters, compounds 1-5 showed potent antibacterial activity with mic values ranging from ... | 2017 | 28779658 |
| regional differences in antibiotic-resistant pathogens in patients with pneumonia: implications for clinicians. | antibiotic resistance is of great concern for both infection control and the treatment of infectious diseases. previous studies reported that the occurrence of drug-resistant pathogens (drps)-for instance, methicillin-resistant staphylococcus aureus (mrsa), pseudomonas aeruginosa and extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae-were associated with inappropriate antibiotic treatment that resulted in adverse outcomes. in addition, unnecessary use of broad-spectrum antibiotics ... | 2017 | 28779516 |
| dna aptamer functionalized gold nanostructures for molecular recognition and photothermal inactivation of methicillin-resistant staphylococcus aureus. | in this work, we report the development of dna aptamer-functionalized gold nanoparticles (apt@au nps) and gold nanorods (apt@au nrs) for inactivation of methicillin-resistant staphylococcus aureus (mrsa) with targeted photothermal therapy (ptt). although both apt@au nps and apt@au nrs specifically bind to mrsa cells, apt@au nps and apt@au nrs inactivated ∼5% and over 95% of the cells,respectively through ptt. this difference in inactivation was based on the relatively high longitudinal absorptio ... | 2017 | 28778062 |
| the neutraclear® needleless connector is equally effective against catheter colonization compared to microclave®. | neutral-valve closed-system connectors can reduce the frequency of catheter colonization. commercially available closed system connectors need to be tested and compared with each other to assess how they protect against contamination. we aimed to compare, in vitro, the efficacy of connectors neutraclear® and microclave® against contamination under conditions of daily clinical practice. | 2017 | 28777419 |
| prevalence and genetic characteristics of staphylococcus aureus and staphylococcus argenteus isolates harboring panton-valentine leukocidin, enterotoxins, and tsst-1 genes from food handlers in myanmar. | asymptomatic carriers of toxigenic staphylococcus aureus are potential source of diseases, including food poisoning. toxigenic potential and genetic traits of colonizing s. aureus were investigated for 563 healthy food handlers in myanmar. carriage of s. aureus was found in 110 individuals (19.5%), and a total of 144 s. aureus isolates were recovered from nasal cavities (110 isolates) and hands (34 isolates). panton-valentine leucocidin genes (pvl) were detected in 18 isolates (12.5%), among whi ... | 2017 | 28777321 |
| targeted metabolic profiling rapidly differentiates escherichia coli and staphylococcus aureus at species and strains level. | pathogenic food-borne bacteria have been associated with severe infectious disease in humans and animals worldwide. rapid detection and screening of these foodborne pathogens are critical for our food safety. this study aimed at detecting escherichia coli and staphylococcus aureus, two important foodborne bacteria, from species and strains/serovar level using mass spectrometry (ms)-based targeted metabolic profiling approach. | 2017 | 28776775 |
| dalbavancin for outpatient parenteral antimicrobial therapy of skin and soft tissue infections in a returning traveller : proposal for novel treatment indications. | skin and soft tissue infections (sstis) are among the most common health problems in travellers returning from tropical and subtropical countries. importantly, the prevalence of staphylococcus aureus, the most common pathogen for purulent sstis, with specific drug resistance, such as methicillin resistant staphylococcus aureus (mrsa) and those expressing virulence genes, such as panton-valentine-leukocidin is higher in tropical regions than in most high resource settings. this poses challenges f ... | 2017 | 28776100 |
| inactivation of model viruses and bacteria in human fresh frozen plasma using riboflavin and long wave ultraviolet rays. | pathogen reduction technologies are among methods to eliminate transfusion transmitted infections. mirasol method using riboflavin in combination with ultraviolet rays is one of them. the aims of this study were to investigate the effectiveness of mirasol method to inactivate some model pathogens as well as examination of the sensitivity of plasma proteins after treatment. | 2017 | 28775824 |
| antimicrobial activity of endophytic bacterial populations isolated from medical plants of iran. | endophytic actinobacteria colonize inside the plant tissues without causing damages to the host plant. since these microorganisms colonize in the different parts of plants and can stop plant disease, they have been applied as biological agents for controlling human diseases. the aim of this study was molecular identification and measuring the antimicrobial activity of endophytic actinomycetes isolated from medicinal plants of iran. | 2017 | 28775818 |
| eradication of methicillin resistant s. aureus biofilm by the combined use of fosfomycin and β-chloro-l-alanine. | biofilm formation is an important virulence factor for methicillin-resistant staphylococcus aureus (mrsa). fosfomycin is a borad-spectrum antibiotic with inhibitory effects on biofilm production and β-chloro-l-alanine (β-cla) is an amino acid analog. the aim of this study was to determine effect of the combination of fosfomycin and β-cla on biofilm production by mrsa isolates. also, the clonal relatedness of the isolates was evaluated. | 2017 | 28775817 |
| non-pseudomonal ecthyma gangrenosum caused by methicillin-resistant staphylococcus aureus (mrsa) in a chronic alcoholic patient. | we report for the first time a case of non-pseudomonal ecthyma gangrenosum (eg) caused by methicillin-resistant staphylococcus aureus in a chronic alcoholic without an associated immunocompromised state or disease. eg is an infection of the skin, commonly associated with pseudomonas aeruginosa bacteraemia, though other organisms are also known to be causally related. it usually occurs in patients who are terminally ill and the immunocompromised. in our case, chronic alcoholism with suppression o ... | 2017 | 28775089 |
| estimating the impact post randomization changes in staff behavior in infection prevention trials: a mathematical modeling approach. | randomized controlled trials (rcts) of behavior-based interventions are particularly vulnerable to post-randomization changes between study arms. we assess the impact of such a change in a large, multicenter study of universal contact precautions to prevent infection transmission in intensive care units. | 2017 | 28774285 |
| synthesis and structural characterization of silver nanoparticles stabilized with 3-mercapto-1-propansulfonate and 1-thioglucose mixed thiols for antibacterial applications. | the synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (agnps) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. first, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3mps) and 1-β-thio-d-glucose (tg). the investigation of the structural and electronic properties of the nano-systems was carried o ... | 2016 | 28774148 |
| cellulose nanocrystal membranes as excipients for drug delivery systems. | in this work, cellulose nanocrystals (cncs) were obtained from flax fibers by an acid hydrolysis assisted by sonochemistry in order to reduce reaction times. the cavitation inducted during hydrolysis resulted in cnc with uniform shapes, and thus further pretreatments into the cellulose are not required. the obtained cnc exhibited a homogeneous morphology and high crystallinity, as well as typical values for surface charge. additionally, cnc membranes were developed from cnc solution to evaluatio ... | 2016 | 28774122 |
| bacterial infection and implant loosening in hip and knee arthroplasty: evaluation of 209 cases. | the aim of this study was to evaluate bacteria species detected in a large number of patients treated for prosthetic joint infection of the hip and knee at a single specialized center. furthermore, the rate of implant loosening was investigated in a time-dependent manner for the most frequently detected bacteria species. a retrospective analysis of patients (n = 209) treated for prosthetic joint infection of the hip and knee was performed. the following parameters were evaluated: c-reactive prot ... | 2016 | 28773989 |
| evaluation of the antimicrobial activity of different antibiotics enhanced with silver-doped hydroxyapatite thin films. | the inhibitory and antimicrobial effects of silver particles have been known since ancient times. in the last few years, a major health problem has arisen due to pathogenic bacteria resistance to antimicrobial agents. the antibacterial activities of new materials including hydroxyapatite (hap), silver-doped hydroxyapatite (ag:hap) and various types of antibiotics such as tetracycline (t-hap and t-ag:hap) or ciprofloxacin (c-hap and c-ag:hap) have not been studied so far. in this study we reporte ... | 2016 | 28773899 |
| preparation and properties of electrospun poly (vinyl pyrrolidone)/cellulose nanocrystal/silver nanoparticle composite fibers. | poly (vinyl pyrrolidone) (pvp)/cellulose nanocrystal (cnc)/silver nanoparticle composite fibers were prepared via electrospinning using n,n'-dimethylformamide (dmf) as a solvent. rheology, morphology, thermal properties, mechanical properties, and antimicrobial activity of nanocomposites were characterized as a function of material composition. the pvp/cnc/ag electrospun suspensions exhibited higher conductivity and better rheological properties compared with those of the pure pvp solution. the ... | 2016 | 28773644 |
| silk fiber as the support and reductant for the facile synthesis of ag-fe₃o₄ nanocomposites and its antibacterial properties. | we report a facile and environmentally friendly approach to prepare ag-fe₃o₄-silk fiber nanocomposites. the ag-fe₃o₄-silk fiber acts as: (i) a biocompatible support for the silver nanoparticles; and (ii) a reducing agent for the silver ions. neither additional reducing agents nor toxic organic solvents were used during the preparation process. the ag-fe₃o₄-silk fiber nanocomposites can be actuated by a small household magnet and have high antibacterial activities against both escherichia coli an ... | 2016 | 28773624 |
| chemical characterization and in vitro antibacterial activity of myrcianthes hallii (o. berg) mcvaugh (myrtaceae), a traditional plant growing in ecuador. | myrcianthes hallii (o. berg) mcvaugh (myrtaceae) is a plant native to ecuador, traditionally used for its antiseptic properties. the composition of the hydro-methanolic extract of this plant was determined by submitting it to ultra-high performance liquid chromatography (uhplc) hyphenated to heated-electrospray ionization mass spectrometry and uv detection. the presence of antimicrobial components prompted us to test the extract against methicillin-resistant and methicillin-susceptible staphyloc ... | 2016 | 28773577 |
| antimicrobial properties of diamond-like carbon/silver nanocomposite thin films deposited on textiles: towards smart bandages. | in the current work, a new antibacterial bandage was proposed where diamond-like carbon with silver nanoparticle (dlc:ag)-coated synthetic silk tissue was used as a building block. the dlc:ag structure, the dimensions of nanoparticles, the silver concentration and the silver ion release were studied systematically employing scanning electron microscopy, energy dispersive x-ray spectroscopy and atomic absorption spectroscopy, respectively. antimicrobial properties were investigated using microbio ... | 2016 | 28773494 |
| silver nanocoatings for reducing the exogenous microbial colonization of wound dressings. | the aim of this work was to obtain an antimicrobial coating (nanoag) for polyester-nylon wound dressings (wds) for reducing the risk of exogenous wound related infections. the as-prepared nanoag-wds were characterized by xrd (x-ray diffraction), sem (scanning electron microscopy), tem (transmission electron microscopy), saed (selected area electron diffraction) and irm (infrared microscopy). biological characterization consisted of in vitro evaluation of the interaction with fibroblast cell cult ... | 2016 | 28773468 |
| effect of storage in distilled water for three months on the antimicrobial properties of poly(methyl methacrylate) denture base material doped with inorganic filler. | the colonization of poly(methyl methacrylate) (pmma) denture base materials by pathogenic microorganisms is a major problem associated with the use of prostheses, and the incorporation of antimicrobial fillers is a method of improving the antimicrobial properties of these materials. numerous studies have demonstrated the initial in vitro antimicrobial effectiveness of this type of material; however, reports demonstrating the stability of these fillers over longer periods are not available. in th ... | 2016 | 28773451 |
| deposition of antimicrobial copper-rich coatings on polymers by atmospheric pressure jet plasmas. | inanimate surfaces serve as a permanent reservoir for infectious microorganisms, which is a growing problem in areas in everyday life. coating of surfaces with inorganic antimicrobials, such as copper, can contribute to reduce the adherence and growth of microorganisms. the use of a dc operated air plasma jet for the deposition of copper thin films on acrylonitrile butadiene styrene (abs) substrates is reported. abs is a widespread material used in consumer applications, including hospitals. the ... | 2016 | 28773396 |
| nanoparticles suitable for bcaa isolation can serve for use in magnetic lipoplex-based delivery system for l, i, v, or r-rich antimicrobial peptides. | this paper investigates the synthesis of paramagnetic nanoparticles, which are able to bind branched chain amino acids (bcaas)-leucine, valine, and isoleucine and, thus, serve as a tool for their isolation. further, by this, we present an approach for encapsulation of nanoparticles into a liposome cavity resulting in a delivery system. analyses of valine and leucine in entire complex show that 31.3% and 32.6% recoveries are reached for those amino acids. evaluation of results shows that the succ ... | 2016 | 28773383 |
| rapid assay to assess bacterial adhesion on textiles. | textiles are frequently colonized by microorganisms leading to undesired consequences like hygienic problems. biocidal coatings often raise environmental and health concerns, thus sustainable, biocide-free coatings are of interest. to develop novel anti-adhesive textile coatings, a rapid, reliable, and quantitative high-throughput method to study microbial attachment to fabrics is required, however currently not available. here, a fast and reliable 96-well plate-based screening method is develop ... | 2016 | 28773373 |
| inhibited bacterial adhesion and biofilm formation on quaternized chitosan-loaded titania nanotubes with various diameters. | titania nanotube-based local drug delivery is an attractive strategy for combating implant-associated infection. in our previous study, we demonstrated that the gentamicin-loaded nanotubes could dramatically inhibit bacterial adhesion and biofilm formation on implant surfaces. considering the overuse of antibiotics may lead to the evolution of antibiotic-resistant bacteria, we synthesized a new quaternized chitosan derivative (hydroxypropyltrimethyl ammonium chloride chitosan, hacc) with a 27% d ... | 2016 | 28773281 |
| novel durable antimicrobial ceramic with embedded copper sub-microparticles for a steady-state release of copper ions. | using pottery clay, porous ceramic stones were molded and then decorated with copper sub-microparticles inside the pores. copper added antimicrobial functionality to the clay-based ceramic and showed ability in disinfecting water. populations of both staphylococcus aureus and klebsiella pneumoniae in contaminated water were reduced by >99.9% in 3 h when exposed to an antimicrobial stone. this antimicrobial performance is attributed to a slow release of copper into water at both room and elevated ... | 2017 | 28773135 |
| textural, structural and biological evaluation of hydroxyapatite doped with zinc at low concentrations. | the present work was focused on the synthesis and characterization of hydroxyapatite doped with low concentrations of zinc (zn:hap) (0.01 < xzn < 0.05). the incorporation of low concentrations of zn(2+) ions in the hydroxyapatite (hap) structure was achieved by co-precipitation method. the physico-chemical properties of the samples were characterized by x-ray diffraction (xrd), fourier transform infrared spectroscopy (ftir), x-ray photoelectron spectroscopy (xps), scanning electron microscopy (s ... | 2017 | 28772589 |
| comparative analysis of the composition and active property evaluation of certain essential oils to assess their potential applications in active food packaging. | the antifungal, antibacterial, and antioxidant activity of four commercial essential oils (eos) (thyme, clove, rosemary, and tea tree) from romanian production were studied in order to assess them as bioactive compounds for active food packaging applications. the chemical composition of the oils was determined with the folin-ciocâlteu method and gas chromatography coupled with mass spectrometry and flame ionization detectors, and it was found that they respect the afnor/iso standard limits. the ... | 2017 | 28772407 |
| erratum: methicillin-resistant staphylococcus aureus infection is a risk factor for unplanned return to the operating room in the surgical treatment of a septic knee. | 2017 | 28772330 | |
| eco-friendly fabrication of ag nanostructures using the seed extract of pedalium murex, an ancient indian medicinal plant: histopathological effects on the zika virus vector aedes aegypti and inhibition of biofilm-forming pathogenic bacteria. | the control of zika virus mosquito vectors and well as the development of drugs in the fight against biofilm-forming microbial pathogens, are timely and important challenges in current bionanoscience. here we focused on the eco-friendly fabrication of ag nanostructures using the seed extract of pedalium murex, an ancient indian medicinal plant. initial confirmation of ag nanoparticles (agnps) production was showed by a color change from transparent to dark brown. the uv-visible spectrum (476nm), ... | 2017 | 28772238 |
| swine exposure and methicillin-resistant staphylococcus aureus infection among hospitalized patients with skin and soft tissue infections in illinois: a zip code-level analysis. | methicillin-resistant staphylococcus aureus (mrsa), a bacterial pathogen, is a predominant cause of skin and soft tissue infections (ssti) in the united states. swine-production facilities have been recognized as potential environmental reservoirs of mrsa. to better understand how swine production may contribute to mrsa infection, we evaluated the association between mrsa infection among ssti inpatients and exposure measures derived from national swine inventory data. | 2017 | 28772149 |
| staphylococcus aureus isolated from wastewater treatment plants in tunisia: occurrence of human and animal associated lineages. | the objective was to characterize staphylococcus aureus isolated from two wastewater treatment plants (wwtps) located in tunis city (tunisia), during the period 2014-2015. genetic lineages, antibiotic resistance mechanisms and virulence factors were determined for the recovered isolates. s. aureus isolates were recovered from 12 of the 62 wastewater samples tested (19.35%), and one isolate/sample was characterized, all of them being methicillin-susceptible (mssa). six spa types (t587, t674, t224 ... | 2017 | 28771160 |
| prevalence and risk factors for mrsa nasal colonization among persons experiencing homelessness in boston, ma. | homeless individuals face an elevated risk of methicillin-resistant staphylococcus aureus (mrsa) infection. identifying the prevalence and risk factors for mrsa nasal colonization may reduce infection risk. a cross-sectional study was conducted at a health clinic for homeless persons in boston, ma, usa (n=194). in-person interviews and nasal swab specimens were collected. mrsa isolates were genotyped using pulse-field gel electrophoresis (pfge) and assessed for antibiotic susceptibility. the pre ... | 2017 | 28771129 |
| activity of a novel protonophore against methicillin-resistant staphylococcus aureus. | compound 1-(4-chlorophenyl)-4,4,4-trifluoro-3-hydroxy-2-buten-1-one (compound 1) was identified as a hit against methicillin-resistant staphylococcus aureus (mrsa) strain mw2. | 2017 | 28771026 |
| teixobactin and its analogues: a new hope in antibiotic discovery. | increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance are key challenges to global health. there is, therefore, a continuing need to develop new antibiotics. teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant staphylococcus aureus (mrsa) and mycobacterium tuberculosis. interestingly, it operates by multiple modes of actions and is bact ... | 2017 | 28770988 |
| testing the efficacy of antimicrobial peptides in the topical treatment of induced osteomyelitis in rats. | joint replacement infections and osteomyelitis are among the most serious complications in orthopaedics and traumatology. the risk factors for these infections are often bacterial resistance to antimicrobials. one of the few solutions available to control bacterial resistance involves antimicrobials, which have a different mechanism of action from traditional antibiotics. antimicrobial peptides (amp) appear to be highly promising candidates in the treatment of resistant infections. we have ident ... | 2017 | 28770427 |
| necrotizing pneumonia: an emerging problem in children? | in children, necrotizing pneumonia (np) is an uncommon, severe complication of pneumonia. it is characterized by destruction of the underlying lung parenchyma resulting in multiple small, thin-walled cavities and is often accompanied by empyema and bronchopleural fistulae. | 2017 | 28770121 |
| intracellular survival of staphylococcus aureus in endothelial cells: a matter of growth or persistence. | the gram-positive human pathogen staphylococcus aureus is a leading cause of severe bacterial infections. recent studies have shown that various cell types could readily internalize s. aureus and infected cells have been proposed to serve as vehicle for the systemic dissemination of the pathogen. here we focused on the intracellular behavior of the community-associated methicillin-resistant s. aureus strain usa300. supporting earlier observations, we found that wild-type s. aureus strain usa300 ... | 2017 | 28769913 |
| bacteriophage pattern and methicillin resistance of staphylococcus aureus isolated from hospitalised patients. | ninety two strains of staphylococcus aureus isolated from hospitalized patients were phage grouped and phage typed and their resistance pattern to methicillin were studied. forty five (48.9%) strains were nontypable, followed by mixed group in 23 (25%). the phage groups i, ii, iii, v and miscellaneous groups were 3.3 per cent, 7.6 per cent, 8.7 per cent, 1 per cent and 3.3 per cent respectively. majority of the strains were methicillin resistant. out of 45 nontypable strains 33 (73.3%) were meth ... | 1997 | 28769482 |
| use of amoxicillin and clavulanic acid (augmentin) in the treatment of skin and soft tissue infections in children. | the efficacy and safety of amoxicillin plus clavulanic acid, a combination of antibiotics potentially effective against beta-lactamase producing bacteria, was compared with that of amoxicillin, erythromycin and co-trimoxazole in an open label, randomized trial in 200 children with mild to severe skin and soft tissue infections. the majority (47%) had impetigo. fifty (25%) children had mild pyodermas, 56 (28%) had moderate and 94 (47%) children had severe pyodermas. a pure growth of staphylococcu ... | 1997 | 28769450 |
| synthesis and biological evaluation of novel thioether pleuromutilin derivatives. | to develop new pleuromutilin derivatives as veterinary antibiotic medicines, we designed and synthesized a series of new thioether pleuromutilin derivatives possessing acylthiazolyl moiety based on previously designed derivatives. the antibacterial properties of the prepared pleuromutilin derivatives were assessed in vitro by the broth dilution method against five kinds of bacteria and the mycoplasma mycoplasma gallisepticum (mg). all of the tested compounds displayed moderate to good antibacter ... | 2017 | 28768998 |
| pan-spinal epidural abscess in a diabetic patient. | 2017 | 28768988 | |
| hand hygiene compliance in a universal gloving setting. | the use of gloves for every patient contact (ie, universal gloving) has been suggested as an infection prevention adjunct and alternative to contact precautions. however, gloves may carry organisms unless they are changed properly. in addition, hand hygiene is required before donning and after removing gloves, and there are scarce data regarding glove changing and hand hygiene in a universal gloving setting. | 2017 | 28768591 |
| preparation and characterization of hydroxypropyl chitosan modified with nisin. | nisin had been grafted to hydroxypropyl chitosan (hpcs) using microbial transglutaminase (mtgase) as biocatalyst. hpcs was synthesized from chitosan and propylene oxide under alkali condition. the chemical structures of derivatives were characterized by ft-ir and (1)h nmr spectroscopy. the process conditions were optimized from the aspects of the reaction time, the reaction temperature, the molar ratio of nisin to hpcs and the mass ratio of mtgase to hpcs. in this study, the results of moisture ... | 2017 | 28768185 |
| biosynthesized silver nanoparticles: are they effective antimicrobials? | silver nanoparticles (agnps) are increasingly being used in medical applications. therefore, cost effective and green methods for generating agnps are required. | 2017 | 28767978 |
| methicillin-resistant staphylococcus aureus nasal swab and suction drain tip cultures in 4573 spinal surgeries: efficacy in management of surgical site infections. | a retrospective single-center study. | 2017 | 28767628 |
| comparative study on antistaphylococcal activity of lipopeptides in various culture media. | staphylococcus aureus bacteria are one of the leading microorganisms responsible for nosocomial infections as well as being the primary causative pathogen of skin and wound infections. currently, the therapy of staphylococcal diseases faces many difficulties, due to a variety of mechanisms of resistance and virulence factors. moreover, a number of infections caused by s. aureus are connected with biofilm formation that impairs effectiveness of the therapy. short cationic lipopeptides that are de ... | 2017 | 28767074 |
| pathogen or contaminant? distinguishing true infection from synovial fluid culture contamination in patients with suspected septic arthritis. | isolation of bacteria from synovial fluid (sf) is the gold standard for diagnosis of septic arthritis (sa). contamination results in misdiagnosis and mismanagement. this study identifies clinical characteristics, microbiology, and outcomes of patients with contaminated sf and compares them with patients with true sa. | 2017 | 28766274 |
| evaluation of the antimicrobial activities of ultrasonicated spinach leaf extracts using rapd markers and electron microscopy. | spinach (spinacia oleracea l.) leaves represent an important dietary source of nutrients, antioxidants and antimicrobials. as such, spinach leaves play an important role in health and have been used in the treatment of human diseases since ancient times. here, the aims were to optimize the extraction methods for recovering antimicrobial substances of spinach leaves, determine the minimum inhibitory concentrations (mics) of the antimicrobial substances against escherichia coli and staphylococcus ... | 2017 | 28766036 |
| comparing the action of ht61 and chlorhexidine on natural and model staphylococcus aureus membranes. | ht61 and chlorhexidine (chx) are both putative membrane-active antimicrobials, which non-specifically target the anionic lipids abundant in bacterial membranes. in model systems, the ability of these antimicrobials to partition into lipid monolayers and increase the permeability of lipid bilayers is dependent upon the presence and proportion of anionic lipids such as phosphatidylglycerol. despite their apparent similarity in membrane affinity, we have found that ht61 and chx differ in the extent ... | 2017 | 28765589 |
| acute geriatrics at the front door. | older people with frailty and urgent care needs are major uses of health and social care services. comprehensive geriatric assessment (cga) is an evidence-based approach to improving their outcomes, as well as improving service outcomes. geriatricians form a small proportion of the overall workforce and cannot address the population need alone, so all clinicians (doctors, nurses, therapists and so on) need to engage in delivering cga as a process of care, underpinned by specific competencies - w ... | 2017 | 28765414 |
| role of fatty acid kinase in cellular lipid homeostasis and saers-dependent virulence factor expression in staphylococcus aureus. | the saers two-component system is a master activator of virulence factor transcription in staphylococcus aureus, but the cellular factors that control its activity are unknown. fatty acid (fa) kinase is a two-component enzyme system required for extracellular fa uptake and saers activity. here, we demonstrate the existence of an intracellular nonesterified fa pool in s. aureus that is elevated in strains lacking fa kinase activity. saers-mediated transcription is restored in fa kinase-negative s ... | 2017 | 28765222 |
| nitrite derived from endogenous bacterial nitric oxide synthase activity promotes aerobic respiration. | macrophage-derived nitric oxide (no·) is a crucial effector against invading pathogens. yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce no· via nitric oxide synthase (nos) activity, despite its apparent cytotoxicity. here, we reveal a conserved role for bacterial nos in activating aerobic respiration. we demonstrate that nitrite generated from endogenous no· decomposition stimulates quinol oxidase activity in staphylococcus aureus and in ... | 2017 | 28765220 |
| microbial load in septic and aseptic procedure rooms. | highly effective measures to prevent surgical wound infections have been established over the last two decades. we studied whether the strict separation of septic and aseptic procedure rooms is still necessary. | 2017 | 28764834 |
| participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in aedes mosquito cell lines. | better knowledge of the innate immune system of insects will improve our understanding of mosquitoes as potential vectors of diverse pathogens. the ubiquitously expressed 14-3-3 protein family is evolutionarily conserved from yeast to mammals, and at least two isoforms of 14-3-3, the ε and ζ, have been identified in insects. these proteins have been shown to participate in both humoral and cellular immune responses in drosophila. as mosquitoes of the genus aedes are the primary vectors for arbov ... | 2017 | 28764795 |
| evaluation of the antibacterial power and biocompatibility of zinc oxide nanorods decorated graphene nanoplatelets: new perspectives for antibiodeteriorative approaches. | nanotechnologies are currently revolutionizing the world around us, improving the quality of our lives thanks to a multitude of applications in several areas including the environmental preservation, with the biodeterioration phenomenon representing one of the major concerns. | 2017 | 28764786 |
| relationship between day 1 and day 2 vancomycin area under the curve values and emergence of heterogeneous vancomycin-intermediate staphylococcus aureus (hvisa) by etest® macromethod among patients with mrsa bloodstream infections: a pilot study. | in vitro data suggests that suboptimal initial vancomycin exposure may select for heterogeneous vancomycin-intermediate staphylococcus aureus (hvisa) infections. however, no clinical studies have evaluated the relationship between initial vancomycin exposure and emergence of hvisa. this pilot study seeks to assess the relationship between day 1 and day 2 vancomycin area under the curve (auc) and emergence of hvisa bloodstream infections (bsis) by etest® macromethod among patients with a non-hvis ... | 2017 | 28764660 |
| lipoteichoic acid isolated from staphylococcus aureus induces both epithelial-mesenchymal transition and wound healing in hacat cells. | lipoteichoic acid (lta), a cell wall component of gram-positive bacteria, is recognized by toll-like receptor (tlr) 2, expressed on certain mammalian cell surfaces, initiating signaling cascades that include nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb) and mitogen-activated protein kinase (mapk). there are many structural and functional varieties of lta, which vary according to the different species of gram-positive bacteria which produce them. in this study, we examine ... | 2017 | 28764320 |
| phenolic acids and flavonoids of peanut by-products: antioxidant capacity and antimicrobial effects. | peanut skin (ps) and meal from dry-blanched peanuts (mdbp) were evaluated as sources of phenolic compounds. ps rendered the highest total phenolic content, antioxidant capacity towards abts radical cation, dpph and hydroxyl radicals as well as reducing power. phenolic acids were present in ps and mdbp whereas proanthocyanidins and monomeric flavonoids were found only in ps as identified by hplc-dad-esi-ms(n). procyanidin-rich extracts prevented oxidation in non-irradiated and gamma-irradiated fi ... | 2017 | 28764032 |
| preparation, antioxidant and antimicrobial evaluation of hydroxamated degraded polysaccharides from enteromorpha prolifera. | in order to improve the antioxidant and antimicrobial abilities, hydroxamated degraded polysaccharides from enteromorpha prolifera (hcdpe) were prepared from the corresponding carboxymethylated degraded polysaccharides (cdpe). hcdpe was characterized by ft-ir. the weight-average molecular weight of hcdpe was determined as 55.4kda. the in vitro antioxidant activity of hcdpe was evaluated by determining the radical (1,1-diphenyl-2-picrylhydrazyl (dpph), hydroxyl and superoxide anion radicals) scav ... | 2017 | 28764023 |
| screening bioactivity and bioactive constituents of nordic unifloral honeys. | the objective of this study was to screen the antibacterial and antioxidant activity of thirty nine honey samples from finland, sweden, norway and denmark. their physicochemical properties were analysed, antioxidant activity was evaluated by dpph assay and antibacterial activity against pseudomonas aeruginosa and staphylococcus aureus was assessed by microdilution assay. the honey samples obtained were buckwheat, caraway, clover, dandelion, fireweed, heather, lime tree, lingonberry, rape, raspbe ... | 2017 | 28763988 |
| synthesis and in vitro evaluation of peracetyl and deacetyl glycosides of eugenol, isoeugenol and dihydroeugenol acting against food-contaminating bacteria. | essential oils, as well as their separate components, have shown promise as alternatives to synthetic preservatives. therefore, it would be interesting to optimize the effect of these compounds and to evaluate their applicability as additives in food. to this end, six peracetyl and deacetyl glycosides were synthesized from eugenol, isoeugenol and dihydroeugenol. all of the glycosides were characterized by ir and nmr. the synthesized compounds and their aglycones were evaluated to determine their ... | 2017 | 28763946 |
| ph-responsive chitosan nanoparticles from a novel twin-chain anionic amphiphile for controlled and targeted delivery of vancomycin. | the design and synthesis of novel ph-responsive nanoantibiotics is an emerging research area to address the antibiotic resistance crisis. the purpose of this study was therefore to synthesize a new anionic gemini surfactant (ags) that could result in the formulation of ph-responsive chitosan nanoparticles (csnps) to treat methicillin-resistant staphylococcus aureus (mrsa) infections. the coupling of oleic acid with 2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane and subsequent deprotection follo ... | 2017 | 28763772 |
| investigating the biosynthesis of natural products from marine proteobacteria: a survey of molecules and strategies. | the phylum proteobacteria contains a wide array of gram-negative marine bacteria. with recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. this has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant staphylococcus aureus (mrsa) and cancer. of equal in ... | 2017 | 28762997 |
| investigating intracellular persistence of staphylococcus aureus within a murine alveolar macrophage cell line. | staphylococcus aureus is a particularly difficult pathogen to eradicate from the respiratory tract. previous studies have highlighted the intracellular capacity of s.aureus in a number of phagocytic and non-phagocytic cells. the aim of this study was to define s.aureus interaction within a murine alveolar macrophage cell line. | 2017 | 28762868 |
| evolution of defence cocktails: antimicrobial peptide combinations reduce mortality and persistent infection. | the simultaneous expression of costly immune effectors such as multiple antimicrobial peptides is a hallmark of innate immunity of multicellular organisms, yet the adaptive advantage remains unresolved. here, we test current hypotheses on the evolution of such defence cocktails. we use rnai gene knock-down to explore, the effects of three highly expressed antimicrobial peptides, displaying different degrees of activity in vitro against staphylococcus aureus, during an infection in the beetle ten ... | 2017 | 28762573 |
| site-specific protein labeling via sortase-mediated transpeptidation. | strategies for site-specific protein modification are highly desirable for the construction of conjugates containing non-genetically-encoded functional groups. ideally, these strategies should proceed under mild conditions, and be compatible with a wide range of protein targets and non-natural moieties. the transpeptidation reaction catalyzed by bacterial sortases is a prominent strategy for protein derivatization that possesses these features. naturally occurring or engineered variants of sorta ... | 2017 | 28762490 |
| progress in definition, prevention and treatment of fungal infections in cystic fibrosis. | cystic fibrosis (cf) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. the main bacterial species causing infections include pseudomonas aeruginosa, staphylococcus aureus, haemophilus influenzae and achromobacter xy ... | 2017 | 28762125 |
| formulation of menthol-loaded nanostructured lipid carriers to enhance its antimicrobial activity for food preservation. | purpose: due to the antimicrobial property, menthol have significant potential for food preservation and foodstuff shelf life improvement. nevertheless, menthol instability, insolubility, and rapid crystallization in aqueous media make it unsuitable for used in food products. this work was aimed to prepare menthol-loaded nanostructured lipid carriers (nlcs) to enhance its antimicrobial activity. methods: morphology, particle size and size distribution, encapsulation efficiency percent (ee%), and ... | 2017 | 28761828 |
| immuno-biosensor for detection of cd20-positive cells using surface plasmon resonance. | purpose: surface plasmon resonance (spr) sensing confers a real-time assessment of molecular interactions between biomolecules and their ligands. this approach is highly sensitive and reproducible and could be employed to confirm the successful binding of drugs to cell surface targets. the specific affinity of monoclonal antibodies (mab) for their target antigens is being utilized for development of immuno-sensors and therapeutic agents. cd20 is a surface protein of b lymphocytes which has been ... | 2017 | 28761820 |
| antimicrobial activities of widely consumed herbal teas, alone or in combination with antibiotics: an in vitro study. | because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. we examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of pseudomonas aeruginosa, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae, enterococcus faecalis, methicillin susceptible/resistant s ... | 2017 | 28761777 |
| efficacy of recombinant bovine epidermal growth factor in the treatment of experimental subclinical staphylococcus aureus mastitis in a ewe model. | staphylococcus aureus is the most common contagious mastitis pathogen of dairy cattle. antimicrobial treatment of infected cattle results in variable cure rates. epidermal growth factor (egf) plays an important role in the modulation of host innate immune responses and the regulation of mammary epithelial regeneration, indicating that egf may be useful as a treatment for mastitis. a pilot study was conducted to evaluate the efficacy of recombinant bovine egf (rbegf) for the treatment of s aureus ... | 2017 | 28761665 |
| a prospective randomised trial of isolated pathogens of surgical site infections (ssi). | every surgical wound is colonized by bacteria, but only a small percentage displays symptoms of infection. the distribution of pathogens isolated in surgical site infections has not significantly changed over the last decades. staph. aureus, coag(-) staphylococci, enterococcus spp and e. coli are the main strains appearing. in addition, a continuously rising proportion of surgical site infections caused by resistant bacterial species (mrsa, c. albicans) has been reported. | 2017 | 28761643 |
| molecular epidemiology and phylogenomics of staphylococcus aureus bacteremia in latin-america: a prospective cohort multicenter study in nine countries. | staphylococcus aureus are important pathogens causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. bloodstream infections are particularly important and the treatment approach is complicated by the presence of methicillin resistance among s. aureus isolates (mrsa). emergence of new genetic lineages of mrsa has occurred in latin america (la) with the rise and dissemination of the community-associated usa300 latin american variant (usa300 ... | 2017 | 28760895 |
| the potential of alcohol release doorplates to reduce surface contamination during hand contact. | optimal hand hygiene may be compromised by contact with contaminated environmental surfaces. | 2017 | 28760635 |