Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| detection of hepatitis e virus genotype 1 among blood donors from southwest of iran. | infection with hepatitis e virus (hev) is endemic in developing countries and reveals significant regional differences. several studies have reported virus transmission via blood transfusion. to date, however, no cases of hev rna detection in blood donors have been reported from iran. | 2016 | 27630719 |
| coinfection of hepatitis e virus and other hepatitis virus in colombia and its genotypic characterization. | hepatitis e virus has emerged as a public health problem, particularly in developing countries. the four genotypes identified in mammals include the g3 found in indigenous hepatitis in countries and regions with high porcine population, and the g1, associated with maternal deaths. | 2015 | 27622794 |
| hepatitis e virus antibodies in finnish veterinarians. | we investigated hepatitis e virus (hev) infections in finnish veterinarians engaged in different practice specialties and evaluated the effect of different background factors on hev exposure by examining total hev antibodies in samples collected from the participants of the 2009 national veterinary congress in helsinki, finland. finnish veterinarians commonly have total hev antibodies with seroprevalence of 10.2%. of the non-veterinarians, 5.8% were seropositive. increasing age was associated wi ... | 2017 | 27621202 |
| extended microbiological characterization of göttingen minipigs: porcine cytomegalovirus and other viruses. | to prevent transmission of zoonotic microorganisms from pig transplants to human recipients when performing xenotransplantation using pig cells, tissues, or organs, donor pigs have to be carefully characterized. göttingen minipigs (gömp) are often used for various biomedical investigations and are well characterized concerning the presence of numerous bacteria, fungi, viruses, and parasites. recently, we studied the prevalence and expression of porcine endogenous retroviruses and the prevalence ... | 2016 | 27615035 |
| surface modulatable nanocapsids for targeting and tracking toward nanotheranostic delivery. | nanoparticle diagnostics and therapeutics (nanotheranostics) have significantly advanced cancer detection and treatment. however, many nanotheranostics are ineffective due to defects in tumor localization and bioavailability. an engineered hepatitis e virus (hev) nanocapsid is a proposed platform for targeted cancer-cell delivery. self-assembling from hev capsid subunits, nanocapsids retain the capacity to enter cells and resist proteolytic/acidic conditions, but lack infectious viral elements. ... | 2016 | 27610752 |
| natural infection with avian hepatitis e virus and marek's disease virus in brown layer chickens in china. | in the present study, avian hepatitis e virus (hev) and serotype-1 strains of marek's disease virus (mdv-1) were detected from a flock of 27-wk-old brown layer hens in china, accompanied by an average daily mortality of 0.44%. postmortem examination of 25 sick hens and five apparently healthy hens selected randomly from the flock showed significant pathologic changes consistent with hepatitis-splenomegaly syndrome (hss), including hepatomegaly, peritoneal fluid, and hepatic subcapsular hemorrhag ... | 2016 | 27610734 |
| hepatitis virus infections in poultry. | viral hepatitis in poultry is a complex disease syndrome caused by several viruses belonging to different families including avian hepatitis e virus (hev), duck hepatitis b virus (dhbv), duck hepatitis a virus (dhav-1, -2, -3), duck hepatitis virus types 2 and 3, fowl adenoviruses (fadv), and turkey hepatitis virus (thv). while these hepatitis viruses share the same target organ, the liver, they each possess unique clinical and biological features. in this article, we aim to review the common an ... | 2016 | 27610716 |
| hepatitis e: discovery, global impact, control and cure. | hepatitis e was identified as an epidemic of non-a, non-b hepatitis from kashmir, india in 1978. hepatitis e virus (hev), the etiological agent is the sole member of family hepeviridae. the virus has marked heterogeneity and infects many animals like bats, camel, chicken, deer, boar, mongoose, pigs, rats, rabbit and cutthroat trout. hepatitis e is a disease with a major global impact and has two distinct epidemiological patterns. hepatitis e is an imperative health issue in developing nations, t ... | 2016 | 27610014 |
| hepatitis e in blood donors: investigation of the natural course of asymptomatic infection, germany, 2011. | asymptomatic hepatitis e virus (hev) infections have been found in blood donors from various european countries, but the natural course is rarely specified. here, we compared the progression of hev viraemia, serostatus and liver-specific enzymes in 10 blood donors with clinically asymptomatic genotype 3 hev infection, measuring hev rna concentrations, plasma concentrations of alanine/aspartate aminotransferase, glutamate dehydrogenase and bilirubin and anti-hev iga, igm and igg antibodies. rna c ... | 2016 | 27608433 |
| treatment of hepatitis e virus. | over the last 10 years, it has become apparent that hepatitis e virus (hev) is a pathogen of global significance. in contrast to hev in the developing world, hev in developed countries is caused by hev genotypes 3 and 4, which are enzoonotic with a porcine primary host and cause both acute and chronic infection. chronic infection occurs in the immunosuppressed, including transplant recipients, and untreated can cause rapidly progressive cirrhosis. | 2016 | 27607911 |
| acute, recent and past hev infection among voluntary blood donors in china: a systematic review and meta-analysis. | hepatitis e virus is one of new threats to blood safety which was usually considered to be transmitted via fecal-oral route. china is one of the hyperendemic regions where frequent outbreaks of hepatitis e are noted. however, the overall prevalence of hev infection among mainland chinese blood donors is not clear until now. | 2016 | 27597991 |
| hepatitis e virus in pork and variety meats sold in fresh markets. | swine is an economically important livestock, yet pork consumption and close contact with pigs are associated with the risk of hepatitis e virus (hev) infection. limited data on the prevalence of hev in southeast asia have mainly examined farm animals. to investigate the potential zoonotic transmission of hev from dietary consumption of pork and variety meats (i.e., offal or organ meats), we obtained 1090 liver, 559 pork meat, and 556 intestine samples from fresh markets in the bangkok metropoli ... | 2017 | 27580911 |
| no evidence of rat hepatitis e virus excretion into urine of rats. | to investigate whether rat hepatitis e virus (rat hev) is excreted into the urine of rats, we infected three wistar and six nude rats with rat hev and examined the rat hev rna in serum, fecal and urine samples. we detected rat hev rna in the serum and fecal samples of all rats but not in the urine. our results suggest that in rats, rat hev is not transmitted via urine. | 2016 | 27580584 |
| factors influencing occurrence of postpartum haemorrhage in pregnant women with hepatitis e infection and deranged coagulation profile. | coagulopathy is an important complication associated with hepatitis e virus (hev) infection in pregnant women. postpartum haemorrhage (pph) remains a serious risk while managing the labour of these women. the aim of this paper is to study the factors influencing the occurrence of pph in pregnant women with hepatitis e infection with coagulopathy. the labours of 38 pregnant women with hepatitis e and deranged coagulation profile were followed. factors that may predict postpartum bleeding complica ... | 2011 | 27579103 |
| erratum to: hepatitis e virus in farmed rabbits, wild rabbits and petting farm rabbits in the netherlands. | 2016 | 27577506 | |
| a korean patient with guillain-barré syndrome following acute hepatitis e whose cholestasis resolved with steroid therapy. | autochthonous hepatitis e virus (hev) is an emerging pathogen in developed countries, and several cases of acute hev infection have been reported in south korea. however, there have been no reports on hev-associated guillain-barré syndrome (gbs) in korea. we recently experienced the case of a 58-year-old korean male with acute hev infection after ingesting raw deer meat. persistent cholestasis was resolved by the administration of prednisolone. at 2.5 months after the clinical presentation of he ... | 2016 | 27572076 |
| monitoring of anti-hepatitis e virus antibody seroconversion in asymptomatically infected blood donors: systematic comparison of nine commercial anti-hev igm and igg assays. | diagnosis of hepatitis e virus (hev) is usually determined serologically by detection of the presence of immunoglobulin (ig)m antibodies or rising anti-hev igg titers. however, serological assays have demonstrated a significant variation in their sensitivities and specificities. in this study, we present the systematic comparison of different immunological anti-hev assays using complete seroconversion panels of 10 virologically confirmed hev genotype 3 infected individuals. assay sensitivities w ... | 2016 | 27556482 |
| assessment of domestic pigs, wild boars and feral hybrid pigs as reservoirs of hepatitis e virus in corsica, france. | in corsica, extensive pig breeding systems allow frequent interactions between wild boars and domestic pigs, which are suspected to act as reservoirs of several zoonotic diseases including hepatitis e virus (hev). in this context, 370 sera and 166 liver samples were collected from phenotypically characterized as pure or hybrid wild boars, between 2009 and 2012. in addition, serum and liver from 208 domestic pigs belonging to 30 farms were collected at the abattoir during the end of 2013. anti-he ... | 2016 | 27556478 |
| high prevalence of anti-hepatitis e virus antibodies in outpatients with chronic liver disease in a university medical center in germany. | hepatitis e virus (hev) is an emerging disease in developed countries. hev seroprevalence ranges from 3.2 to 10% in europe, but is higher in endemic areas such as southern france. in germany, an increasing incidence of hev infections has been reported recently. risk factors for the acquisition of hev are incompletely understood. | 2016 | 27552296 |
| quantification of hev rna by droplet digital pcr. | the sensitivity of real-time pcr for hepatitis e virus (hev) rna quantification differs greatly among techniques. standardized tools that measure the real quantity of virus are needed. we assessed the performance of a reverse transcription droplet digital pcr (rt-ddpcr) assay that gives absolute quantities of hev rna. analytical and clinical validation was done on hev genotypes 1, 3 and 4, and was based on open reading frame (orf)3 amplification. the within-run and between-run reproducibilities ... | 2016 | 27548205 |
| a linear surface epitope in a proline-rich region of orf3 product of genotype 1 hepatitis e virus. | hepatitis e virus (hev) is one of the viral pathogens causing hepatitis in humans. hev open reading frame 3 (orf3) encodes a small multifunctional protein (vp13), which is essential for hev infection. in this study, a linear epitope was identified in a polyproline (pxxp) motif from vp13 of genotype 1 hev by using a monoclonal antibody. the epitope was detected in enzyme-linked immunosorbent assay (elisa), immunoblotting and immunofluorescence assays. epitope mapping showed that the epitope locat ... | 2016 | 27548202 |
| role of envelopment in the hev life cycle. | hepatitis e virus (hev), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. however, recent studies have revealed that the virus circulating in the patient's blood is completely cloaked in host membranes and resistant to neutralizing antibodies. the discovery of this novel enveloped form of hev has raised a series of questions about the fundamental biology of hev and the way this virus, which has been understudied in the past, interacts with its host. her ... | 2016 | 27548201 |
| viral hepatitis: indian scenario. | viral hepatitis is a cause for major health care burden in india and is now equated as a threat comparable to the "big three" communicable diseases - hiv/aids, malaria and tuberculosis. hepatitis a virus and hepatitis e virus are predominantly enterically transmitted pathogens and are responsible to cause both sporadic infections and epidemics of acute viral hepatitis. hepatitis b virus and hepatitis c virus are predominantly spread via parenteral route and are notorious to cause chronic hepatit ... | 2016 | 27546957 |
| epidemiological investigation of a tap water-mediated hepatitis e virus genotype 4 outbreak in zhejiang province, china. | an outbreak of acute hepatitis recently occurred in a nursing home in zhejiang province, china. the objectives of this study were to confirm the outbreak and identify the aetiology, source and transmission patterns. all residents and staff in or near the nursing home during the period from 1 october 2014 to 21 may 2015 were investigated regarding hygiene and for epidemiological information including water and food (eating meat especially pork products). serum and stool specimens were collected f ... | 2016 | 27546066 |
| the global burden of hepatitis e outbreaks: a systematic review. | hepatitis e virus (hev) is responsible for repeated water-borne outbreaks since the past century, representing an emerging issue in public health. however, the global burden of hev outbreak has not been comprehensively described. we performed a systematic review of confirmed hev outbreaks based on published literatures. hev outbreaks have mainly been reported from asian and african countries, and only a few from european and american countries. india represents a country with the highest number ... | 2017 | 27542764 |
| apolipoprotein e polymorphisms and their protective effect on hepatitis e virus replication. | 2016 | 27541341 | |
| treatment of hev infection in patients with a solid-organ transplant and chronic hepatitis. | hepatitis e virus (hev) infection can cause hepatic and extra-hepatic manifestations. treatment of hev infection has been thoroughly studied in solid-organ-transplant patients who have developed a chronic hev infection. in this review, we report on our current knowledge regarding treatment of hev infection. | 2016 | 27537905 |
| quantification of hepatitis e virus in naturally-contaminated pig liver products. | hepatitis e virus (hev), the cause of self-limiting acute hepatitis in humans, is widespread and endemic in many parts of the world. the foodborne transmission of hev has become of concern due to the identification of undercooked pork products as a risk factor for infection. foodborne enteric viruses are conventionally processed by quantitative rt-pcr (rt-qpcr), which gives sensitive and quantitative detection results. recently, digital pcr (dpcr) has been described as a novel approach to genome ... | 2016 | 27536278 |
| the bama miniature swine is susceptible to experimental hev infection. | the hepatitis e virus (hev) is one of the main causes of enterically transmitted hepatitis worldwide. although the mortality rates associated with hev are generally low, they can be up to 28% in hev-infected pregnant women, and the elderly are more susceptible. the reasons for this selective severity are unclear, partially because there is no suitable, easy-to-use model in which to study hev infection. non-human primates and standard swine have been identified as being sensitive to infection wit ... | 2016 | 27534702 |
| hepatitis e virus mutations: functional and clinical relevance. | hepatitis e virus (hev) infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized hev-related deaths worldwide. hev is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. although hev replication is controlled by the host immune system, viral factors (especially specific viral genotypes and mutants) can modulate hev replication, ... | 2016 | 27528267 |
| a case report about the most common yet most forgotten hepatitis e. | background hepatitis e virus (hev) is the most common cause of enterically acquired acute viral hepatitis worldwide with major prevalence in the developing countries. an increasing number of sporadic cases of acute hev infection have also been found in developed countries, but there is still no role for hev testing in cases of seronegative acute hepatitis in such nonendemic regions. case report a 59-year-old male residing in the united states for seven months with a history of malaria treated on ... | 2016 | 27527551 |
| hepatitis e pathogenesis. | although most hepatitis e virus (hev) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. chronic hev infections may also occur in immunocompromised patients. this review describes how our understanding of the pathogenesis of hev infection has progressed in recent years. | 2016 | 27527210 |
| companion animals as a source of viruses for human beings and food production animals. | companion animals comprise a wide variety of species, including dogs, cats, horses, ferrets, guinea pigs, reptiles, birds and ornamental fish, as well as food production animal species, such as domestic pigs, kept as companion animals. despite their prominent place in human society, little is known about the role of companion animals as sources of viruses for people and food production animals. therefore, we reviewed the literature for accounts of infections of companion animals by zoonotic viru ... | 2016 | 27522300 |
| hepatitis e virus infection in the irish blood donor population. | hepatitis e virus (hev) genotype 3 (g3) infection is a zoonosis that may be transmitted during the acute phase by transfusion. the aim of this study was to determine the incidence of hev and seroprevalence among irish blood donors. | 2016 | 27522065 |
| chronic hepatitis e - an emerging disease in an immunocompromised host. | chronic hepatitis e virus (hev) infection is increasingly being reported in immunosuppressed individuals with hiv, patients with haematological malignancy and transplant recipients. the diagnosis of cirrhosis and liver failure post chronic hev is controversial due to lack of standard diagnostic criteria. the treatment benefits of ribavirin in chronic hev of genotype 1 are not well reported. we report a case of chronic hev infection of genotype 1 leading to chronic liver disease in a child cured ... | 2016 | 27516529 |
| serological evidence of infection with rodent-borne hepatitis e virus hev-c1 or antigenically related virus in humans. | zoonotic potential of a rat-derived hepatitis e virus (hev), designated as hev-c1, remains unknown. to evaluate the risk for hev-c1 infection in humans, paired sera of 208 hospitalized febrile patients collected from 2001 to 2003 in hanoi, vietnam, were examined for igg antibodies to hev-c1 and genotype 1 hev (hev-1), which is common in humans. igg antibodies to virus-like particles (vlps) of hev-c1 and/or hev-1 were detected from 99 of the 208 convalescent sera in enzyme-linked immunosorbent as ... | 2016 | 27499185 |
| [acute hepatitis due to hepatitis e virus after raw meat consumption]. | 2016 | 27496809 | |
| hepatitis e virus in acute liver failure: an unusual suspect? | 2016 | 27496198 | |
| high prevalence of anti-hepatitis e virus antibodies among blood donors in central italy, february to march 2014. | prevalence of anti-hepatitis e virus (hev) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central italy in january and february 2014 for anti-hev igg and igm and hev rna. data on hev exposure were collected from all donors. overall anti-hev igg prevalence was 49% (153/313). eating raw dried pig-liver sausage was the only independ ... | 2016 | 27494608 |
| expanding host range and cross-species infection of hepatitis e virus. | 2016 | 27490119 | |
| development and validation of a new serum standard for the measurement of anti-hev antibodies in animals. | although hepatitis e virus (hev) infection is a zoonosis, there is, currently, no standardized assay for quantitatively measuring anti-hev antibody levels in hev animal reservoirs. in this study, anti-hev antibody positive serum from a rabbit (rs26) was calibrated by dose-response parallel line assay using the world health organization (who) reference standard for anti-hev antibodies. after evaluating the stability of the rs26 serum, a quantification assay of anti-hev antibodies using rs26 as a ... | 2017 | 27487450 |
| analysis of adaptive mutations selected during the consecutive passages of hepatitis e virus produced from an infectious cdna clone. | to characterize the genomic mutations of hepatitis e virus (hev) during consecutive passages associated with adaptation to growth in cell culture, a cloned genotype 3 hev [pje03-1760f/wt, starting virus (sv)] was passaged 10 times in a549 cells, and the entire genomic sequence of the passage 10 (p10) progeny was determined. compared to sv, p10 virus possessed two non-synonymous (t2808c and a5054g) and four synonymous mutations (c1213t, t2557c, c3118t and c4435t) in the orf1. full-length infectio ... | 2016 | 27485920 |
| hepatitis e virus infections in travellers: assessing the threat to the australian blood supply. | in many developed countries hepatitis e virus (hev) infections have occurred predominantly in travellers to countries endemic for hev. hev is a potential threat to blood safety as the virus is transfusion-transmissible. to minimise this risk in australia, individuals diagnosed with hev are deferred. malarial deferrals, when donors are restricted from donating fresh blood components following travel to an area in which malaria is endemic, probably also decrease the hev risk, by deferring donors w ... | 2016 | 27483488 |
| a rat model for hepatitis e virus. | hepatitis e virus (hev) is one of the prime causes of acute viral hepatitis, and chronic hepatitis e is increasingly recognized as an important problem in the transplant setting. nevertheless, the fundamental understanding of the biology of hev replication is limited and there are few therapeutic options. the development of such therapies is partially hindered by the lack of a robust and convenient animal model. we propose the infection of athymic nude rats with the rat hev strain la-b350 as suc ... | 2016 | 27483350 |
| hepatitis e virus in developed countries: one of the most successful zoonotic viral diseases in human history? | until recently, hepatitis e was thought to be largely confined to hyperendemic areas in asia, africa and mexico. over the last 10 years it has become clear that this is not the case, as it is surprisingly common in developed countries. in these settings, it is caused by hev genotypes 3 and 4, and is a porcine zoonosis. it causes a range of human illness including acute and chronic hepatitis, and a spectrum of neurological injury. hev rna has been found in donated blood from an increasing number ... | 2015 | 27482393 |
| hepatitis e virus antibody prevalence, rna frequency, and genotype among blood donors in cambodia (southeast asia). | recent studies conducted in developed countries described hepatitis e virus (hev) as an emerging infectious threat to blood safety. however, data on hev among blood donors from southeast asia are lacking. | 2016 | 27480100 |
| susceptibility of pigs to zoonotic hepatitis e virus genotype 3 isolated from a wild boar. | in europe, zoonotic hepatitis e virus (hev) genotype 3 strains mainly circulate in humans, swine and wild boar. the aim of this study was to investigate the potential transmission of a wild boar originating hev strain (wbhev) to swine by intravenous or oral inoculation and to study the consequences of infection of a wbhev strain, a wbhev strain previously passaged in a pig and a swine hev strain after oral inoculation. firstly, an intravenous infection was performed for which five piglets were d ... | 2016 | 27477944 |
| evolution of hepatitis e virus-associated meningo-polyradiculoneuropathy on ribavirin. | 2016 | 27470489 | |
| increased hepatitis e virus seroprevalence correlates with lower cd4+ cell counts in hiv-infected persons in argentina. | hepatitis e virus (hev) is a single-stranded rna virus that can cause hepatitis in an epidemic fashion. hev usually causes asymptomatic or limited acute infections in immunocompetent individuals, whereas in immunosuppressed individuals such as transplant recipients, hev can cause chronic infections. the risks and outcomes of hev co-infection in patients infected with human immunodeficiency virus (hiv) are poorly characterized. we used a third generation immunoassay to measure serum igg antibodie ... | 2016 | 27467394 |
| incidence and seroprevalence of hepatitis e virus infection in pregnant women infected with hepatitis b virus and antibody placental transfer in infants. | hepatitis e has poor outcomes in pregnant women. superinfection of hepatitis e virus (hev) in patients infected with hepatitis b virus (hbv) may worsen liver disease. | 2016 | 27467017 |
| crystal structure of the human astrovirus capsid protein. | human astrovirus (hastv) is a leading cause of viral diarrhea in infants and young children worldwide. hastv is a nonenveloped virus with a t=3 capsid and a positive-sense rna genome. the capsid protein (cp) of hastv is synthesized as a 90-kda precursor (vp90) that can be divided into three linear domains: a conserved n-terminal domain, a hypervariable domain, and an acidic c-terminal domain. maturation of hastv requires proteolytic processing of the astrovirus cp both inside and outside the hos ... | 2016 | 27466429 |
| hepatitis e virus derived from different sources exhibits different behaviour in virus inactivation and/or removal studies with plasma derivatives. | hepatitis e virus (hev) causes viral hepatitis, and is considered a risk factor for blood products. although some hev inactivation/removal studies have been reported, detailed investigations of different manufacturing steps as heat treatment, partitioning during cold ethanol fractionation, low ph treatment, and virus filtration have yet to be reported for plasma-derived medicinal products. in this study, human serum- and swine faeces-derived hevs, with and without detergent treatment, were used. ... | 2016 | 27461242 |
| hepatitis e: prevention and treatment. | infection with the hepatitis e virus (hev) is very common worldwide. the epidemiology, viral genotypes, and transmission routes differ between low-resource countries and economically developed countries. these differences have resulted in the design of diverse prevention and treatment strategies to combat hev. | 2016 | 27454402 |
| hepatitis e viral loads in plasma pools for fractionation. | it is now recognized that blood donors may be silently infected with hepatitis e virus (hev) and that plasma pools used in the manufacture of plasma-derived medicinal products may also contain detectable virus rna. the occurrence of hev-infected blood and plasma donors can vary considerably depending on local epidemiology. | 2016 | 27453197 |
| production of infectious dromedary camel hepatitis e virus by a reverse genetic system: potential for zoonotic infection. | the pathogenicity, epidemiology and replication mechanism of dromedary camel hepatitis e virus (dchev), a novel hepatitis e virus (hev), has been unclear. here we used a reverse genetic system to produce dchev and examined the possibility of zoonotic infection. | 2016 | 27449916 |
| viral macro domains reverse protein adp-ribosylation. | adp-ribosylation is a posttranslational protein modification in which adp-ribose is transferred from nad(+) to specific acceptors to regulate a wide variety of cellular processes. the macro domain is an ancient and highly evolutionarily conserved protein domain widely distributed throughout all kingdoms of life, including viruses. the human targ1/c6orf130, macrod1, and macrod2 proteins can reverse adp-ribosylation by acting on adp-ribosylated substrates through the hydrolytic activity of their m ... | 2016 | 27440879 |
| islet cell transplantation from göttingen minipigs to cynomolgus monkeys: analysis of virus safety. | xenotransplantation using pig cells, tissues or organs may be associated with the transmission of porcine zoonotic micro-organisms. hepatitis e virus (hev), porcine cytomegalovirus (pcmv) and porcine endogenous retroviruses (pervs) are potentially zoonotic micro-organisms which do not show clinical symptoms in pigs and which are due to the low expression level difficult to detect. göttingen minipigs (gömp) are often used for biomedical investigations and they are well characterized concerning th ... | 2016 | 27440468 |
| possible foodborne transmission of hepatitis e virus from domestic pigs and wild boars from corsica. | 2016 | 27437570 | |
| genotype 1 hepatitis e virus infection with acute acalculous cholecystitis as an extrahepatic symptom: a case report. | hepatitis e virus (hev) causes an acute viral hepatitis that is transmitted enterically. it is epidemic in africa, asia, the middle east, and central america. it is known that hev can cause extrahepatic manifestations. here, we report the first case of acalculous cholecystitis as an extrahepatic symptom of hev. | 2016 | 27433137 |
| detection and phylogenetic analysis of the hepatitis e virus in a canadian swine production network. | viral contamination along the production chain is a significant concern in both food safety and livestock health. pigs have been reported to act as a reservoir for zoonotic viruses, sometimes emerging ones, and epidemiological studies have shown direct links between the consumption of uncooked pork offal and cases of hepatitis caused by the hepatitis e virus (hev) genotype 3 in humans. the presence of hev in swine herds has been reported, but its dissemination in pork production environments is ... | 2016 | 27422131 |
| liver failure due to acute viral hepatitis (a-e). | viral hepatitis is still one of the key causes of acute liver failure (alf) in the world. | 2016 | 27413724 |
| incidence of hepatitis e virus infection in recipients of blood or blood products transfusion. | hepatitis e, generally known to be transmitted faeco-orally, has been shown to have significant transmission by blood borne route. paucity of data on asymptomatic viremia in blood donors and higher incidence of hepatitis e in haemodialysis patients and thalassemics mandate a prospective study of blood recipients to elucidate the exact incidence and natural history of post transfusion hepatitis e. | 2010 | 27408301 |
| outbreak of viral hepatitis e in a regimental training centre. | an outbreak of viral hepatitis occurred in a regimental centre with 265 cases occurring during a 3 months period. | 2005 | 27407798 |
| hepatitis e virus: assessment of the epidemiological situation in humans in europe, 2014/15. | hepatitis e virus (hev) is endemic in eu/eea countries, but the understanding of the burden of the infection in humans is inconsistent as the disease is not under eu surveillance but subject to national policies. | 2016 | 27393938 |
| detection and genetic characterization of hepatitis e virus (hev) genotype 3 subtype c in wild boars in italy. | hepatitis e virus (hev) was detected in stools collected from wild boars in italy, with an overall prevalence of 1.5 % (3/196). the sequence of a ~3.0-kb portion at the 3' end of the genome of one such strain, hev/wb/p6-15/ita, was determined. in the full-length orf2, which encodes the capsid protein, the virus was genetically closest to wild boar and human hev strains currently classified as genotype 3 subtype c. interestingly, the 3' end of orf2 of the wb/p6-15/ita matched the 340-nucleotide ( ... | 2016 | 27393602 |
| guillain-barré and miller fisher syndromes in patients with anti-hepatitis e virus antibody: a hospital-based survey in japan. | there have been reports from several countries that hepatitis e virus (hev) infection is frequently associated with guillain-barré syndrome (gbs). this study aimed to determine the frequency of hev infection associated with gbs in japanese patients, and to clarify the clinical characteristics of these patients. sera obtained from 63 patients with gbs or miller fisher syndrome (mfs) and 60 control subjects were examined for both hev-igm and hev-igg. of the 63 patients, three were positive for bot ... | 2016 | 27389141 |
| low transfusion transmission of hepatitis e among 25,637 single-donation, nucleic acid-tested blood donors. | hepatitis e virus genotype-3 (hev-gt-3) causes autochthonous infections in western countries, with a primary reservoir in animals, especially pigs. hev transfusion transmission has been reported, and hev-gt-3 prevalence is high in some european countries. the prevalence of hev rna was investigated among danish blood donors, and the prevalence of hev transfusion-transmitted infection (tti) was investigated among recipients. | 2016 | 27385646 |
| hepatitis e virus: a cross-sectional serological and virological study in pigs and humans at zoonotic risk within a high-density pig farming area. | an increase in autochthonous hepatitis e virus (hev) infections has been recorded in italy suspected to be zoonotically transmitted from pigs; this study was carried out to determinate the seroprevalence and risk factors associated with hepatitis hev exposition, both in swine and humans working in pig farms, located within a high-density pig farming area in piedmont region, north-western italy. the presence of viral rna in human and swine samples was also evaluated, and phylogenetic analysis was ... | 2016 | 27380833 |
| travelers lowering their guard: a bacterial, viral and protozoan co-infection after a five-day journey in india. | we present a case of concurrent infections by campylobacter jejuni, giardia intestinalis and hepatitis e virus acquired during a 5-days travel to india by an italian traveller : professionals responsible for pre- and post-travel care should underline food and water precautions and prescribe an adequate diagnostic work-up in symptomatic patients. | 2016 | 27378368 |
| [neurological symptoms with a hepatitis e virus infection]. | infection with hepatitis e virus genotype 3 (hev3) is an emerging zoonosis in the industrialized world. the infection usually proceeds asymptomatically. extrahepatic sequelae including neurological symptoms have been described. | 2016 | 27378260 |
| the relationship between serology of hepatitis e virus with liver and kidney function in kidney transplant patients. | although hepatitis e virus (hev) is well known to cause acute hepatitis, there are reports showing that hev may also be responsible for progression of acute to chronic hepatitis and liver cirrhosis in patients receiving organ transplantation. in this study, we aimed to evaluate the prevalence of hev in patients with kidney transplantation. in this study, 110 patients with kidney transplantation were recruited, and anti-hev igg, creatinine, alanine transaminase (alt), aspartate aminotransferase ( ... | 2016 | 27366144 |
| guillain-barré syndrome following acute co-super-infection of hepatitis e virus and cytomegalovirus in a chronic hepatitis b virus carrier. | guillain-barré syndrome (gbs) is a rare neurological complication of hepatitis b. gbs presence in acute hepatitis e virus (hev) and cytomegalovirus (cmv) infection is also sporadically reported. here, a rare case of gbs in a chronic hepatitis b virus carrier co-infected with hev and cmv was reported. based on the analysis on the progress of the manifestations and virus serological detection results, it could be concluded that gbs might mostly likely result from super-infection of hev and cmv. th ... | 2017 | 27358107 |
| hepatitis e in israel: a nation-wide retrospective study. | to investigate the epidemiology, risk factors and clinical course of acute hepatitis e virus (hev) infection in israel, an industrialized country. | 2016 | 27350735 |
| corrigendum to "hepatitis e virus infection in the hiv-positive patient" [j. clin. virol. 80 (2016) 102-106]. | 2016 | 27345249 | |
| hepatitis e virus infection--a new threat for europe. | of 20 million of patients infected with hepatitis e virus (hev) worldwide 57 thousand dies each year. hev-infection is not longer regarded as a diseases in developing endemic countries of asia, africa and latin america. the majority of european countries faces increasing number of endemic infections. they are caused by seven different genotypes and be responsible for acute and chronic infections. hev is of zoonotic origin causing infections in pigs and boars which are a source of infection for h ... | 2016 | 27344467 |
| clinical and virological profiling of sporadic hepatitis e virus infection in china. | recently, genotype 4 hev (hev-4) associated hepatitis e has overtaken hev-1 infections in china, but few studies reported the clinical and virological features of hev-4 infection. | 2016 | 27343562 |
| evidence of hepatitis e virus breaking through the blood-brain barrier and replicating in the central nervous system. | neurologic dysfunctions such as guillain-barre' syndrome, encephalitis, meningitis and transverse myelitis occur frequently in patients with hepatitis e virus (hev) infection, and this study was conducted to better characterize the role of hev in the pathogenesis of neurologic disorders. genotype 4 strain of swine hev was used to inoculate mongolian gerbils. reverse transcription-nested polymerase chain reaction (rt-npcr), elisa, histopathology, ultrastructural pathology and enzyme immunohistoch ... | 2016 | 27329366 |
| ifn regulatory factor 1 restricts hepatitis e virus replication by activating stat1 to induce antiviral ifn-stimulated genes. | ifn regulatory factor 1 (irf1) is one of the most important ifn-stimulated genes (isgs) in cellular antiviral immunity. although hepatitis e virus (hev) is a leading cause of acute hepatitis worldwide, how isgs counteract hev infection is largely unknown. this study was conducted to investigate the effect of irf1 on hev replication. multiple cell lines were used in 2 models that harbor hev. in different hev cell culture systems, irf1 effectively inhibited hev replication. irf1 did not trigger if ... | 2016 | 27328944 |
| hepatitis e virus rna-dependent rna polymerase: rna template specificities, recruitment and synthesis. | hepatitis e virus (hev) is a positive-sense rna virus and member of the genus orthohepevirus in the family hepeviridae. although hev rna-dependent rna polymerase (hev-rdrp) plays an important role in the hev life cycle, its template specificities are not completely understood. we expressed hev-rdrp protein with his-tag in a bacterial system and analysed template specificities using different putative cis-regulatory elements in the hev genome. the enzyme showed highest affinity for the 3' non-cod ... | 2016 | 27324050 |
| clinical and virological features of acute hepatitis e in gunma prefecture, japan between 2004 and 2015. | to evaluate the clinical and virological features of acute hepatitis e (ah-e) in gunma prefecture and focus on the hepatitis e virus (hev) infection in immunocompromised patients. | 2016 | 27322051 |
| detection of subtle differences in analogous viral capsid proteins by allowing unrestricted specific interaction in solution competition elisa. | assay artifacts were reported in plate-based immuoassays during the assessment of specific molecular interactions owing to the surface induced aggregation/conformational changes. to circumvent surface adsorption and associated artifacts, we used a solution competition elisa by allowing unrestricted interaction between binding partners to occur in solution for better discrimination between epitopes with subtle differences. a difference of two orders of magnitude in binding to neutralizing antibod ... | 2016 | 27321427 |
| report of a novel c1483w mutation in the hepatitis e virus polymerase in patients with acute liver failure. | here, we report the molecular alterations in the hev genome from patients with acute liver failure (alf) and acute viral hepatitis (avh) from north india, including pregnant women and its association with the poor outcome of the disease. we partially sequenced the rna dependent rna polymerase (rdrp) region of the orf 1 protein in the hev genome from representative samples from patients with alf and avh and identified two novel mutations cysteine 1483 tryptophan and asparagine 1530 threonine in 1 ... | 2016 | 27320795 |
| detection of hepatitis e virus and other livestock-related pathogens in iowa streams. | manure application is a source of pathogens to the environment. through overland runoff and tile drainage, zoonotic pathogens can contaminate surface water and streambed sediment and could affect both wildlife and human health. this study examined the environmental occurrence of gene markers for livestock-related bacterial, protozoan, and viral pathogens and antibiotic resistance in surface waters within the south fork iowa river basin before and after periods of swine manure application on agri ... | 2016 | 27318519 |
| hepatitis e virus infection in dromedaries, north and east africa, united arab emirates, and pakistan, 1983-2015. | a new hepatitis e virus (hev-7) was recently found in dromedaries and 1 human from the united arab emirates. we screened 2,438 dromedary samples from pakistan, the united arab emirates, and 4 african countries. hev-7 is long established, diversified and geographically widespread. dromedaries may constitute a neglected source of zoonotic hev infections. | 2016 | 27315454 |
| hepatitis e virus in 3 types of laboratory animals, china, 2012-2015. | we found seroprevalences for hepatitis e virus (hev) of 7.5%, 18.5%, and 83.3% in specific pathogen-free (spf) laboratory rabbits, monkeys, and pigs, respectively, in china. hev rna was detected in 4.8% of spf rabbits, and 11 rabbits had latent infections. screening for hev in spf animals before relevant experiments are conducted is recommended. | 2016 | 27314902 |
| acute graft dysfunction 17 years after liver transplant: a challenging clinical and histologic manifestation of hepatitis e. | acute hepatitis e virus infection after liver transplant is a challenging clinical phenomenon. due to its unspecific clinical and histological presentation, the diagnosis of acute or chronic hepatitis e virus infection can be difficult in unclear cases of elevated liver enzymes. here, we report the case of a 56-year-old male patient who presented to our center for 17-year follow-up after liver transplant with α1-antitrypsin deficiency. the patient was asymptomatic but had remarkably increased tr ... | 2016 | 27310664 |
| epidemiology of hepatitis e virus in iran. | iran is known as an endemic country for hepatitis e virus (hev) infection, while there are variations in the epidemiology of hev infection throughout the country. the available epidemiological studies in different regions of iran show hev seroprevalence of 1.1%-14.2% among general population, 4.5% -14.3% among blood donors, 6.1%-22.8% among injecting drug users, 6.3%-28.3% among hemodialysis patients, 1.6%-11.3% among patients infected with other hepatitis viruses, 27.5% among patients with chro ... | 2016 | 27298557 |
| excretion of infectious hepatitis e virus into milk in cows imposes high risks of zoonosis. | hepatitis e virus (hev) represents the main cause of acute hepatitis worldwide. hev infection in immunocompromised patients involves a high risk for the development of chronic hepatitis. because hev is recognized as a zoonotic pathogen, it is currently believed that swine is the primary reservoir. however, this is not sufficient to justify the strikingly high seroprevalence of hev in both developing and western countries. thus, this study aimed to identify new zoonotic sources that bear a high r ... | 2016 | 27286751 |
| differential immune responses in mice immunized with recombinant neutralizing epitope protein of hepatitis e virus formulated with liposome and alum adjuvants. | in the developing countries, hepatitis e virus (hev) is a predominant cause of sporadic acute hepatitis in adults and waterborne epidemics leading to high mortality in pregnant women. vaccine development mainly focuses on the structural capsid protein open-reading-frame-2 (orf-2) of the virus. we successfully evaluated liposome-adjuvanted recombinant neutralizing epitope protein (rnep), a part of orf-2, 458-607aa, in mice and rhesus macaques. we compared immune response to adjuvants alone, rnep ... | 2016 | 27285290 |
| divergent hepatitis e virus in birds of prey, common kestrel (falco tinnunculus) and red-footed falcon (f. vespertinus), hungary. | hepatitis e virus (hev), family hepeviridae, has raised considerable public health concerns because of its zoonotic potential; however, the animal to animal transmissions and the natural chain of hepevirus infections in wildlife are less known. using random amplification and next generation sequencing technology a novel hev in birds of prey was serendipitously identified in hungary. hev rna was detected in total of 2 (18%) of the 11 and 1 (14%) of the 7 faecal samples from common kestrels and re ... | 2016 | 27282471 |
| hepatitis e virus in donor plasma collected in japan. | human hepatitis e virus (hev) is prevalent worldwide. iatrogenic hev has recently been identified based on the reports of transfusion-transmitted cases. the detection rate of hev-rna and seroprevalence of hev-igg/igm have been regionally evaluated in japan, and donor plasma collected in hokkaido is currently screened by nucleic acid amplification testing. however, the detection rate of hev-rna in blood donors in japan outside of hokkaido has not been reported. | 2016 | 27280485 |
| epidemiological characteristics and clinical manifestations of hepatitis e virus infection in bulgaria: a report on 20 patients. | hepatitis e is one of the leading clinical manifestations of acute viral hepatitis in developing countries. in industrialized countries, during the past several years, sporadic "autochthonous" cases of hev infection have been increased. | 2016 | 27276860 |
| the orf3 protein of genotype 1 hepatitis e virus suppresses tlr3-induced nf-κb signaling via tradd and rip1. | hepatitis e virus (hev) genotype 1 infection is common and can emerge as outbreaks in developing areas, thus posing a threat to public health. however, due to the absence of feasible animal models, the mechanism of he pathogenesis remains obscure. the hev pathogenic mechanism has been suggested to be mediated by the immune system and not by direct viral duplication. we firstly discovered that the open reading frame 3 (orf3) protein of genotype 1 hev downregulates tlr3-mediated nf-κb signaling in ... | 2016 | 27270888 |
| [infection by the hepatitis e virus as a precipitating factor of parsonage-turner syndrome]. | 2016 | 27270680 | |
| hepatitis e seroprevalence and related risk factors among seafood processing workers: a cross-sectional survey in shandong province, china. | this study aimed to assess the seroprevalence of hepatitis e virus (hev) infection and the potential risk factors for acquiring hev infection in the seafood processing factories in yantai city of shandong province, china. | 2016 | 27265612 |
| new insights into the hepatitis e virus genotype 3 phylodynamics and evolutionary history. | hepatitis e virus (hev) is an emergent hepatotropic virus endemic mainly in asia and other developing areas. however, in the last decade it has been increasingly reported in high-income countries. human infecting hev strains are currently classified into four genotypes (1-4). genotype 3 (hev-3) is the prevalent virus genotype and the mostly associated with autochthonous and sporadic cases of hev in developed areas. the evolutionary history of hev worldwide remains largely unknown. in this study ... | 2016 | 27264728 |
| [hepatitidis e virus]. | the number of detected cases of hepatitis e (he) shows an increasing trend in the czech republic, probably due the introduction of new diagnostic methods and greater awareness of he. in most cases, the source of infection has remained unconfirmed or entirely unclear. the causative agent, the hepatitis e virus (hev), belongs to the hepeviridae family. recently, many isolates from mammals, birds, and fish have been identified. hev is widespread among farm pigs and wild boar populations all over th ... | 2016 | 27246639 |
| hepatitis e virus genotype 3 in sewage and genotype 1 in acute hepatitis cases, israel. | hepatitis e virus (hev) is an emerging infectious agent in developed countries. hev genotypes 1 (g1) and 3 (g3) have been identified in environmental and clinical samples in europe. in israel, the overall prevalence of anti-hev igg antibodies was found to be 10.6%; however, reports of hev infection are scarce. in this study, the presence of hev in israel was investigated using 169 sewage samples from 32 treatment facilities and 49 samples from acute hepatitis patients, all collected between 2013 ... | 2016 | 27246446 |
| hepatitis e virus infection in the hiv-positive patient. | hepatitis e virus (hev) is a rna virus that can cause hepatitis. in immunocompetent individuals, infection with hev usually leads to asymptomatic seroconversion. however, in immunosuppressed patients, such as transplant recipients, hev can develop into a chronic infection. studies regarding the seroprevalence and clinical implications of hev in patients infected with the human immunodeficiency virus (hiv) are conflicting. levels of cd4 count in blood seem to be the most widely associated risk fa ... | 2016 | 27243210 |
| multiplex qpcr for serodetection and serotyping of hepatitis viruses: a brief review. | the present review describes the current status of multiplex quantitative real time polymerase chain reaction (qpcr) assays developed and used globally for detection and subtyping of hepatitis viruses in body fluids. several studies have reported the use of multiplex qpcr for the detection of hepatitis viruses, including hepatitis a virus (hav), hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis d virus (hdv), and hepatitis e virus (hev). in addition, multiplex qpcr has also been develo ... | 2016 | 27239109 |