Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control. | background: previous reports concerning the prevalence of human papillomavirus (hpv) in oral squamous cell carcinoma (oscc) have observed varied results. the aim of this study was to evaluate the prevalence of hpv in oral premalignant lesions (opl) and oscc. for accurate hpv detection in oral lesions, comparative analysis was performed on cervical lesions as positive controls. methods: fifty-seven cases with opl and 50 with oscc were selected. twenty-nine control cases were selected from cervica ... | 2011 | 21528380 |
| a fast and simple in situ pcr method to detect human papilloma virus infection in archival paraffin-embedded tissues. | we describe a simple and fast method for the detection and localization of low copy numbers of hpv dna in formalin-fixed and paraffin-embedded archival tissues. we have developed a protocol for direct bl situ-pcr in order to demonstrate its convenience in rapid and reproducible assessment of hpv infection in unknown biopsies. the morphological aspect of the tissues has been maintained, despite the multiple steps of fixation, permeabilization and thermal cycling, and positivity has been detected ... | 1997 | 21528242 |
| risks for persistence and progression by human papillomavirus type 16 variant lineages among a population-based sample of danish women. | background: little is known about factors determining hpv16 persistence and progression, but several studies have suggested that genetic variants may play a role. methods: hpv16-positive women with normal cytology in a large danish cohort were re-assessed for hpv16 status at 2 years, and followed-up for cervical intraepithelial neoplasia 3 or worse (cin3+) over 11 years through linkage with a national pathology database. relative risks for clearance, persistence and progression were compared by ... | 2011 | 21527576 |
| shedding of epstein-barr virus and cytomegalovirus from the genital tract of women in a peri-urban community in andhra pradesh, india. | we found a large number of false-positive via (visual inspection with acetic acid) readings in a study of cervical cancer screening strategies (via, hpv dna testing, and pap cytology) in a peri-urban community in andhra pradesh, india. we evaluated whether these false-positives might be occurring as a result of infections with epstein-barr virus (ebv) or cytomegalovirus (cmv), prevalent latent herpesviruses known to be shed from the female genital tract. while we found that there was no associat ... | 2011 | 21525227 |
| [whim syndrome: on the track of an interplay between human papillomavirus and the cxcl12 chemokine]. | 2011 | 21524391 | |
| human papillomavirus (hpv) prevalence and accuracy of hpv testing to detect high-grade cervical intraepithelial neoplasia. | concern was raised on using testing for high-risk (hr) human papillomavirus (hpv) in cervical cancer screening in populations where hpv prevalence is high. the impact of hr hpv prevalence on the efficiency of hpv test-based screening has never been directly evaluated. a meta-regression of the relationship between hr hpv prevalence and the specificity and positive predictive value (ppv) of hpv dna testing for the presence of cervical intraepithelial neoplasia grade 2 or worse (cin2+) was performe ... | 2011 | 21520039 |
| targeting hepatitis b virus and human papillomavirus induced carcinogenesis: novel patented therapeutics. | viral infections leading to carcinogenesis tops the risk factors list for the development of human cancer. the decades of research has provided ample scientific evidence that directly links 10-15% of the worldwide incidence of human cancers to the infections with seven human viruses. moreover, the insights gained into the molecular pathogenetic and immune mechanisms of hepatitis b virus (hbv) and human papillomavirus (hpv) viral transmission to tumour progression, and the identification of their ... | 2011 | 21517743 |
| reducing the rate of cervical cancer: ethical challenges in public health. | human papilloma virus (hpv) is the most common sexually transmitted infection in the united states and hpv is the single most significant risk factor for acquiring cervical cancer. there are two vaccines that prevent some strains of hpv and are believed to help reduce the rate of cervical cancer: whether or not the hpv vaccine should be mandated has resulted in monumental debates and given rise to several ethical concerns. for instance, how will mandating this vaccine affect the patient's right ... | 2010 | 21516924 |
| anogenital warts in danish men who have sex with men. | to determine the prevalence of anogenital warts (agws) and concurrent sexually transmitted infections (stis) in men who have sex with men (msm), and their knowledge of human papillomavirus (hpv). attitudes towards the hpv vaccine among msm are explored. a web-based cross-sectional survey on agws, sociodemographic factors and sexual behaviour conducted in august 2009 in denmark. overall 25.2% of the 1184 respondents reported a prior or current episode of agws. the prevalence of agw was significan ... | 2011 | 21515754 |
| "i thought cancer was one of those random things. i didn't know cancer could be caught…": adolescent girls' understandings and experiences of the hpv programme in the uk. | the uk human papillomavirus (hpv) vaccination programme aims to provide girls aged 12-13 with protection against two of the most carcinogenic strains (types 16 and 18) of this sexually transmitted virus which together account for 70% of cases of cervical cancer. despite evidence suggesting a general lack of knowledge about hpv and its link with cervical cancer, vaccine uptake rates were generally high in the uk for the first year of the hpv vaccination programme. in countries that implemented th ... | 2011 | 21514348 |
| multiplexed detection of nucleic acids in a combinatorial screening chip. | multiplexed diagnostic testing has the potential to dramatically improve the quality of healthcare. simultaneous measurement of health indicators and/or disease markers reduces turnaround time and analysis cost and speeds up the decision making process for diagnosis and treatment. at present, however, most diagnostic tests only provide information on a single indicator or marker. development of efficient diagnostic tests capable of parallel screening of infectious disease markers could significa ... | 2011 | 21512691 |
| human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in argentina. | reports on the prevalence and genotypes of hpv among trans (male to female transvestites, transsexuals or transgender) sex workers (tsw) are scarce in the literature. | 2011 | 21511521 |
| hpv e6 proteins target ubc9, the sumo conjugating enzyme. | the human papillomavirus oncogenic protein, e6, interacts with a number of cellular proteins, and for some targets, e6 directs their degradation through the ubiquitin-proteasome pathway. post-translational modification with ubiquitin-like modifiers, such as sumo, also influences protein activities, protein-protein interactions, and protein stability. we report that the high risk hpve6 proteins reduce the intracellular quantity of the sole sumo conjugation enzyme, ubc9, concomitant with decreased ... | 2011 | 21510985 |
| phase 1 randomized trial of the vaginal safety and acceptability of spl7013 gel (vivagel) in sexually active young women (mtn-004). | objectives:: the study was designed to assess the safety, adherence, acceptability, and effect on vaginal microflora of 3% spl7013 gel (vivagel), a novel dendrimer topical microbicide that inhibits hiv, herpes simplex virus-2, and human papillomavirus in vitro and in animal models. design:: phase 1, randomized, double-blind, placebo-controlled study on sexually active women. methods:: sixty-one sexually active women aged 18-24 years were recruited from three sites in the united states. participa ... | 2011 | 21505316 |
| a population-based clinical trial comparing endocervical high-risk hpv testing using hybrid capture 2 and cervista from the shenccast ii study. | our objective was to directly compare the accuracy of the high-risk human papillomavirus (hpv) assays, hybrid capture 2 (hc2; qiagen, gaithersburg, md) and cervista (hologic, bedford, ma), in diagnosing cervical intraepithelial neoplasia (cin) 3 or worse (cancer). a population-based, cross-sectional study (the shenzhen cervical cancer screening trial ii) was conducted in guangdong province in china. three high-risk hpv assays, self and direct cervical sampling and cytology, were studied. abnorma ... | 2011 | 21502436 |
| detection of human papillomavirus using hybrid capture 2 in oral brushings from patients with oropharyngeal squamous cell carcinoma. | detection of high-risk (hr) human papillomavirus (hpv) in oropharyngeal squamous cell carcinoma (scc) has important prognostic implications; patients exhibit improved survival compared with patients with hpv- scc. oral brushing and rinsing samples were obtained from patients with oropharyngeal, oral cavity, or hypopharyngeal scc and tested for hr-hpv using hybrid capture 2 (hc2; qiagen, valencia, ca). hr-hpv in situ hybridization (ish) was performed on biopsy tissue samples from the same patient ... | 2011 | 21502432 |
| single-chain fv fragment antibodies selected from an intrabody library as effective mono- or bivalent reagents for in vitro protein detection. | in spite of their many potential applications, recombinant antibody molecules selected by phage display are rarely available commercially, one reason being the absence of robust bacterial expression systems that yield sufficient quantities of reagents for routine applications. we previously described the construction and validation of an intrabody library that allows the selection of single-chain fv (scfv) fragments solubly expressed in the cytoplasm. here, we show that it is possible to obtain ... | 2011 | 21501618 |
| the combined influence of oral contraceptives and human papillomavirus virus on cutaneous squamous cell carcinoma. | the vast majority of cutaneous squamous cell carcinoma (cscc) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (uvr) exposure. organ transplant recipients also are an important population at great risk for cscc. an association has been reported between oral contraceptive (oc) use, human papillomavirus virus (hpv) and cervical cancer, and there could be a similar association for cscc. the cutaneous hpv β-e6 protein, a close cousin of the transformative e6 ... | 2011 | 21499554 |
| impact of an hpv6/11/16/18 l1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with hpv16/18 infection. | the impact of a human papillomavirus (hpv) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (cin2-3/ais) in women with ongoing hpv16 or 18 infections prevaccination is reported. seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 randomized, placebo-controlled, efficacy trials (protocols 013 and 015). vaccine or placebo was given at day 1, month 2 and 6. women were tested for hpv6/11/16/18 dna and antibodies at da ... | 2011 | 21491420 |
| medical interventions for high grade vulval intraepithelial neoplasia. | vulval intraepithelial neoplasia (vin) is a pre-malignant condition of the vulval skin; its incidence is increasing in women under 50 years. vin is graded histologically as low grade or high grade. high grade vin is associated with infection with human papilloma virus (hpv) infection and may progress to invasive disease. there is no consensus on the optimal management of high grade vin. the high morbidity and high relapse rate associated with surgical interventions call for a formal appraisal of ... | 2011 | 21491403 |
| transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma. | β-human papillomavirus (β-hpv) dna is present in some cutaneous squamous cell carcinomas (cusccs), but no mechanism of carcinogenesis has been determined. we used ultra-high-throughput sequencing of the cancer transcriptome to assess whether papillomavirus transcripts are present in these cancers. in all, 67 cuscc samples were assayed for β-hpv dna by pcr, and viral loads were measured with type-specific quantitative pcr. a total of 31 sccs were selected for whole transcriptome sequencing. trans ... | 2011 | 21490616 |
| [current events in vaccination.] | the annual meeting of the infectious disease society of america (idsa); which brought together nearly 5000 participants from over 80 countries in vancouver, canada, october 21 to 24, 2010; provided a review of the influenza (h1n1) 2009 pandemic, evaluated vaccination programmes and presented new vaccines under development. with 12 500 deaths in the united states in 2009-2010, the influenza (h1n1) 2009 pandemic was actually less deadly than the seasonal flu. but it essentially hit the young, and ... | 2011 | 21489733 |
| smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. | background:to prove a causal link between an epigenetic change and an environmental or behavioural risk factor for a given disease, it is first necessary to show that the onset of exposure precedes the first detection of that epigenetic change in subjects who are still free of disease.methods:towards this end, a cohort of women aged 15-19 years, recruited soon after they first had sexual intercourse, were used to provide sequential observations on the relationship between cigarette smoking and t ... | 2011 | 21487403 |
| immunogenicity and reactogenicity of alternative schedules of hpv vaccine in vietnam: a cluster randomized noninferiority trial. | human papillomavirus (hpv) vaccine programs may decrease the morbidity and mortality due to cervical cancer seen among women in low-resource countries. however, the 3-dose schedule over a 6-month period is a potential barrier to vaccine introduction in such settings. | 2011 | 21486975 |
| advancing human papillomavirus research with a rhesus monkey model. | 2011 | 21483022 | |
| design and characterization of an enhanced repressor of human papillomavirus e2 protein. | papillomaviruses are causative agents of cervical and anogenital cancers. the viral e2 protein mediates viral dna replication and transactivation of viral oncogenes and thus represents a specific target for therapeutic intervention. short forms of e2, e2r, contain only the c-terminal dimerization domain, and repress the normal function of e2 due to formation of an inactive heterodimer. using structure-guided design, we replaced conserved residues at the dimer interface to design a heterodimer wi ... | 2011 | 21482558 |
| hpv vaccine acceptability in ghana, west africa. | cervical cancer is a leading cause of cancer-related mortality among women in ghana. as of this writing no data are available concerning knowledge, attitudes and acceptability of human papillomavirus (hpv) vaccination by women in ghana. | 2011 | 21481327 |
| cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. | please cite this paper as: sharma m, ortendahl j, van der ham e, sy s, kim j. cost-effectiveness of human papillomavirus vaccination and cervical cancer screening in thailand. bjog 2011; 10.1111/j.1471-0528.2011.02974.x. objective to assess the health and economic outcomes of various screening and vaccination strategies for cervical cancer prevention. design cost-effectiveness analysis from a societal perspective. setting thailand. population females aged 9 years and older. methods using a ... | 2011 | 21481160 |
| altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. | abstract conclusions: altered expression of claudin-1, claudin-7, and tricellulin in early tonsillar squamous cell carcinoma (scc) independent of human papilloma virus (hpv) infection may lead to tumor progression. objectives: integral tight junction proteins, the claudins and tricellulin, play a crucial role in all tissues. hpv is significantly associated with tonsillar scc. we sought to determine the expression of claudin-1, claudin-7, and tricellulin in hpv-infected and hpv-free tonsillar scc ... | 2011 | 21480761 |
| methylation status of the long control region of hpv 16 in clinical cervical specimens. | dna methylation is one of the regulatory pathways that modulate human papillomavirus (hpv) gene expression. to obtain detailed methylation information on crucial areas of the long control region (lcr) of hpv 16 and to clarify the significance of methylation in clinical cervical lesions, 80 clinical samples were examined to determine the methylation status of the hpv 16 promoter and enhancer core using bisulfite modification and pyrosequencing. seventy samples [26 of cervical carcinoma (cc), 13 o ... | 2008 | 21479449 |
| what constitutes consent when parents and daughters have different views about having the hpv vaccine: qualitative interviews with stakeholders. | objective the uk human papillomavirus (hpv) vaccine programme commenced in the autumn of 2008 for year 8 (age 12-13 years) schoolgirls. we examine whether the vaccine should be given when there is a difference of opinion between daughters and parents or guardians. design qualitative study using semi-structured interviews. participants a sample of 25 stakeholders: 14 professionals involved in the development of the hpv vaccination programme and 11 professionals involved in its implementati ... | 2011 | 21478419 |
| chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification. | chlamydiae are gram negative, obligate intracellular bacteria, and chlamydia trachomatis is the etiologic agent of the most commonly reported sexually transmitted disease in the united states. chlamydiae undergo a biphasic life cycle that takes place inside a parasitophorous vacuole termed an inclusion. chlamydial infections have been epidemiologically linked to cervical cancer in patients previously infected by human papillomavirus (hpv). the inclusion associates very closely with host cell cen ... | 2011 | 21477082 |
| human papilloma virus screening by hybrid capture ii in chinese women of jiangsu province. | to survey human papilloma virus (hpv) infection in chinese women of jiangsu province and discuss the relationship between hpv and the biology of cervical cancer. | 2010 | 21473391 |
| human papilloma virus associated head and neck cancer: a pcr based study. | head and neck cancers (hnc), 90% of which are squamous cell carcinomas (scc), rank sixth among all malignancies worldwide and comprise 40-50% of the total number of malignancies in india. in addition to alcohol and tobacco usage, which is the major source of oral carcinogens, viruses such as human papilloma virus (hpv) may also contribute to development of the malignancy. the aim of this study was to identify the prevalence of hpv in head and neck cancers using material from metastatic site. a t ... | 2011 | 21472871 |
| assessment of clinical and analytical performance characteristics of an hpv genotyping test. | human papillomavirus (hpv), the known cause of cervical cancer, is found in essentially all cervical cancer specimens. infection with high-risk hpv genotypes carries the greatest risk of viral persistence and the potential to develop precancerous lesions or cervical cancer. identifying women infected with hpv 16 and/or 18, the two genotypes most commonly found in cervical cancer, helps further stratify women for either immediate referral to colposcopy or repeat cytological and hpv dna testing in ... | 2011 | 21472869 |
| il-10 expression is regulated by hpv e2 protein in cervical cancer cells. | it has been found that certain cytokines (il-4, il-10 and tgf-β1) are highly expressed locally in biopsies from patients with premalignant lesions and cervical cancer, and may induce a local immune-suppression state. in particular, il-10 is highly expressed in tumor cells and its expression is directly proportional to the development of hpv-positive cervical cancer, suggesting an important role of hpv proteins in the expression of il-10. in fact, we demonstrated that e6 and e7 hpv proteins regul ... | 2011 | 21468579 |
| prediction of residual/recurrent disease by hpv genotype after loop excision procedure for high-grade cervical intraepithelial neoplasia with negative margins. | this study aims to evaluate whether the preconisation of high-risk human papillomavirus (hr-hpv) genotype and multiple hpv infection is predictive for residual/recurrent disease during the follow-up of high-grade cervical intraepithelial neoplasia (cin) treated by loop electrosurgical excision procedure (leep) with negative margins. | 2011 | 21466511 |
| large loop excision of transformation zone procedures used in the management of cytological abnormalities of the cervix. | national health and medical research council (nhmrc) guidelines published in 2005 changed the management of cervical squamous intraepithelial lesions. asymptomatic low-grade abnormalities may be treated conservatively as many regress spontaneously. cervical changes reflect infection with the human papilloma virus (hpv). risk factors for acquiring hpv are the same as those for other sexually transmitted infections (stis). | 2011 | 21466510 |
| targeted cellular uptake and sirna silencing by quantum-dot nanoparticles coated with ß-cyclodextrin coupled to amino acids. | quantum dots (qds) have the potential to serve as photostable beacons to track sirna delivery, which is fast becoming an attractive approach to probe gene function in cells. in this paper, we synthesized qd nanoparticles coated with ß-cyclodextrin (ß-cd) coupled to amino acids with different surface charges (positive, negative, and neutral) through direct ligand-exchange reactions and used them to deliver sirna. we found that these qds are diffluent in biological buffer with high colloidal stabi ... | 2011 | 21465588 |
| human papillomavirus vaccine: widening the scope for cancer prevention. | human papillomavirus (hpv) is the necessary cause of cervical cancer. the hpv oncoproteins e6 and e7 have crucial roles in various steps of carcinogenesis, inducing degradation of p53 and destabilization of prb. several clinical trials show that recombinant hpv vaccines are safe and effective in preventing persistent infection of hpv and associated anogenital lesions. although most clinical studies to date have investigated the effectiveness of hpv vaccines in young female subjects, elderly fema ... | 2011 | 21465574 |
| disconnects between news framing and parental discourse concerning the state-mandated hpv vaccine: implications for dialogic health communication and health literacy. | in 2007, virginia became the first state in the us to mandate the human papillomavirus (hpv) vaccine. in 2009, the mandate required that parents of girls entering sixth grade (ages 11-12) vaccinate their daughters or sign the 'opt-out' waiver. this investigation is the first to explore how both the news media and parents framed and responded to the newly-mandated hpv vaccine. this research reveals disjoints between news media framing and parental framing. implications of these gaps for parental ... | 2010 | 21462859 |
| virucidal activity of the dendrimer microbicide spl7013 against hiv-1. | topical microbicides for use by women to prevent the transmission of human immunodeficiency virus (hiv) and other sexually transmitted infections are urgently required. dendrimers are highly branched nanoparticles being developed as microbicides. spl7013 is a dendrimer with broad-spectrum activity against hiv type i (hiv-1) and -2 (hiv-2), herpes simplex viruses type-1 (hsv-1) and -2 (hsv-2) and human papillomavirus. spl7013 [3% (w/w)] has been formulated in a mucoadhesive carbopol gel (vivagel® ... | 2011 | 21459115 |
| human papillomavirus 16 e2 stability and transcriptional activation is enhanced by e1 via a direct protein-protein interaction. | human papillomavirus 16 e1 and e2 interact with cellular factors to replicate the viral genome. e2 forms homodimers and binds to 12 bp palindromic sequences adjacent to the viral origin and recruits e1 to the origin. e1 forms a di-hexameric helicase complex that replicates the viral genome. this manuscript demonstrates that e1 stabilises the e2 protein, increasing the half life in both c33a and 293 t cells respectively. this stabilisation requires a direct protein--protein interaction. in additi ... | 2011 | 21458836 |
| cost-effectiveness of different human papillomavirus vaccines in singapore. | human papillomavirus (hpv) vaccines are widely available and there have been studies exploring their potential clinical impact and cost-effectiveness. however, few studies have compared the cost-effectiveness among the 2 main vaccines available - a bivalent vaccine against hpv 16/18, and a quadrivalent vaccine against 6/11/16/18. we explore the cost-effectiveness of these two hpv vaccines in tropical singapore. | 2011 | 21453537 |
| increases in human papillomavirus detection during early hiv infection among women in zimbabwe. | individuals who acquire human immunodeficiency virus (hiv) may experience an immediate disruption of genital tract immunity, altering the ability to mount a local and effective immune response. this study examined the impact of early hiv infection on new detection of human papillomavirus (hpv). | 2011 | 21451006 |
| laryngeal papilloma cells in culture have an altered cytoskeleton. | we have investigated the effect of human papillomavirus (hpv) transformation on cellular cytoarchitecture. cells from laryngeal papillomas and normal epithelium were cultured in vitro. cytoskeletal components of both types of cells were visualized by immunofluorescence, to determine whether there were any differences in the structure or distribution of the cytoskeleton. there was no significant change in microtubules. two major components of the cytoskeleton, the intermediate filaments and the m ... | 1987 | 21449663 |
| the role of human papillomavirus in the pathogenesis of head & neck squamous cell carcinoma: an overview. | cancer statistics report an increased incidence of oscc and opscc around the world. though improvements in screening and early diagnosis have dramatically reduced the incidence of this neoplasm in recent years, the 5-year-disease-free survival, is still poor, specially for oropharyngeal cancer, despite the great scientific and financial efforts. recently, several papers showed that hpv may be involved at least in the pathogenesis of a subgroup of oral and cervical scc, leading to distinct molecu ... | 2011 | 21447181 |
| human papillomavirus genotyping as a predictor of high-grade cervical dysplasia in women with mildly cytologic abnormalities: a two-year follow-up report. | high-risk human papillomavirus (hr-hpv) dna testing has emerged as another testing modality for women with mildly cytologic abnormalities. we conducted a two-year follow-up study of 108 women with mildly abnormal cervical cytology for detection of cin 2/3. a cervical swab sample was obtained for hpv genotyping by a hpv blot and histologic follow-up results were correlated with hr-hpv types. of the 108 cases, 93 (86.1%) were positive for hr-hpv dna. hpv-16 was detected in 45.1% of patients. cin g ... | 2011 | 21442773 |
| p16/ki-67 dual-stain cytology in the triage of ascus and lsil papanicolaou cytology: results from the european equivocal or mildly abnormal papanicolaou cytology study. | the objective of this study was to analyze the diagnostic performance of a newly established immunocytochemical dual-stain protocol, which simultaneously detects p16(ink4a) and ki-67 expression in cervical cytology samples, for identifying high-grade cervical intraepithelial neoplasia (cin2+) in women with papanicolaou (pap) cytology results categorized as atypical squamous cells of undetermined significance (ascus) or low-grade squamous intraepithelial lesions (lsil). | 2011 | 21442767 |
| role and predictive strength of transglutaminase type 2 expression in premalignant lesions of the cervix. | the demonstration that type 2 transglutaminase (tg2) can incorporate polyamine into the e7 oncoprotein of human papillomavirus (hpv) type 18 has led to the hypothesis that tg2 can have a role in the host cellular response to hpv infection. the aim of this study was to investigate whether hpv-related pathology, in infected human cervical epithelium, was associated with modulation of tg2 expression. normal controls and hpv-infected cervical biopsies were analyzed for the expression of tg2, and the ... | 2011 | 21441900 |
| circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect. | surges of serum abs after immunization and infection are highly specific for the offending ag, and recent studies demonstrate that vaccines induce transient increases in circulating ab-secreting cells (ascs). these ascs are highly enriched but not universally specific for the immunizing ag, suggesting that a fraction of these ascs could arise from polyclonal bystander stimulation of preexisting memory cells to unrelated ags. this model is proposed to explain maintenance of long-lived serological ... | 2011 | 21441455 |
| a cyano analogue of boswellic acid induces crosstalk between p53/puma/bax and telomerase that stages the human papillomavirus type 18 positive hela cells to apoptotic death. | the p53 tumor suppressor pathway is disrupted by human papillomavirus (hpv) in over 90% of cervical cancers. hpv e6 protein promotes the degradation of p53 thereby inhibiting its stabilization and activation. this study demonstrates that treatment with a novel cyano derivative of 11-keto-ß-boswellic acid, i.e. butyl 2-cyano-3, 11-dioxours-1,12-dien-24-oate (bcdd) reduced the viral e6 mrna expression and lead to the accumulation of transcriptionally active p53 in the nucleus of hpv18 hela cells f ... | 2011 | 21440536 |
| nuclear translocation of +¦-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression? | high-risk human papillomaviruses (hpvs) constitute an important risk factor for tonsillar cancer. this study describes changes in cell adhesion molecules during metastasis of hpv-related and hpv-unrelated tonsillar carcinomas. | 2011 | 21438909 |
| high-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. | background: the purpose of this study was to determine the role of high-risk human papillomavirus (hpv) in lymph node metastasis and the depth of invasion in oropharyngeal cancer. methods: the study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. high-risk hpv in situ hybridization was performed to detect hpv infection. results: the positive rate of high-risk hpv in situ hybridization was 15.4% (24 of 156). there was a significant difference in the fraction of positive ... | 2011 | 21438064 |
| molecular methods for a correct diagnosis of multiple hpv infections and clinical implications for vaccine. | the human papillomavirus (hpv) family is characterized by minimal genotypic differences corresponding to different virus types. the aim of this study was to detect the hpv coinfections and the inner genotype in a series of 336 cervical-vaginal samples. | 2011 | 21430458 |
| comparison of clinical and analytical performance of the abbott realtime high risk hpv test to the performance of hybrid capture 2 in population-based cervical cancer screening. | the clinical performance of the abbott realtime high risk hpv (human papillomavirus) test (realtime) and that of the hybrid capture 2 hpv dna test (hc2) were prospectively compared in the population-based cervical cancer screening setting. in women >30 years old (n = 3,129), the clinical sensitivity of realtime for detection of cervical intraepithelial neoplasia of grade 2 (cin2) or worse (38 cases) and its clinical specificity for lesions of less than cin2 (3,091 controls) were 100% and 93.3%, ... | 2011 | 21430098 |
| in vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system. | human papillomavirus (hpv) infection is the most common sexually transmitted infection. vaccines for hpv infection can reduce the risk of developing cervical cancer. to further improve such vaccines and to explore other methods of preventing or treating viral infection, longitudinal studies in experimental animals are desirable. here, we describe a newly developed multicolor endoscopic fluorescence imaging system to visualize early hpv infection with fluorescent protein-encoded pseudoviruses (ps ... | 2011 | 21430072 |
| [demyelinating disease and vaccination of the human papillomavirus]. | primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (hpv) types 16 and 18, is now available worldwide. postlicensure adverse neurological effects have been described. the studies realized after the license are descriptive and limited by the difficulty to obtain the information, despite most of the statistical indexes show that the adverse effects by the vaccine of the hpv are not upper compared with other vaccines, the ... | 2011 | 21425100 |
| human papillomavirus-induced lesions on tattoos may show features of seborrheic keratosis. | 2011 | 21422356 | |
| the impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3. | 15-30% of cases of cervical intraepithelial neoplasia grades 2-3 (cin2-3) detected in punch biopsies regress spontaneously (ie, show cin1 or less in the follow-up cone). epithelial retinoblastoma protein (prb), tumour suppressor protein (p53), hpv genotype and immunoreactive cells have been reported to be helpful in predicting regression but their interaction in regression prediction is unknown. | 2011 | 21421698 |
| ki-67 and proexc are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia. | esophageal squamous intraepithelial neoplasia has been widely recognized as a precursor lesion for esophageal squamous cell carcinoma. early detection offers the best prognosis for esophageal squamous cell carcinoma. the differentiation of squamous dysplasia from reactive change and the classification of squamous dysplasia into high-grade or low-grade are sometimes subjective and challenging. in this study, we sought to evaluate multiple biomarkers and to develop clinically useful adjunct tools ... | 2011 | 21420715 |
| a novel real-time genotyping assay for detection of the e6-350g hpv 16 variant. | it has been suggested that some e6 human papillomavirus (hpv) type 16 variants could be involved in viral persistence and progression of hpv infection. a novel one-step allelic discrimination real-time pcr was evaluated for e6-350g variant detection in 102 endocervical hpv 16 positive samples. this assay was also used to assess the distribution of this variant in spanish women with cervical cancer related to hpv 16. the detection limit for the allelic discrimination assay was 50 copies per react ... | 2011 | 21419166 |
| risk factors for hpv infection among american indian and white women in the northern plains. | american indian (ai) women living in the northern plains have high incidence and mortality rates for cervical cancer. we assessed risk factors for human papillomavirus (hpv) infection among ai and white women. | 2011 | 21414655 |
| human papillomavirus's physical state and cyclin a1 promoter methylation in cervical cancer. | cervical cancer is the second biggest cause of death among human female cancers. human papillomavirus (hpv) is the main factor in this cancer, especially hpv types 16 and 18, which constitute the high-risk group. there are 2 physical states of hpv in host cells: integrated and episomal forms. our previous study explored the very high degree of cyclin a1 (ccna1) promoter methylation in invasive cervical cancer in which all cases were infected by hpv. | 2011 | 21412159 |
| mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa. | human papillomaviruses (hpvs) are agents of the most common sexually transmitted diseases in females and males. precise data about the presence, mechanism of infection and clinical significance of hpv in the male reproductive tract and especially in sperm are not available. here we show that hpv can infect human sperm, it localizes at the equatorial region of sperm head through interaction between the hpv capsid protein l1 and syndecan-1. sperm transfected with hpv e6/e7 genes and sperm exposed ... | 2011 | 21408100 |
| alternative her/pten/akt pathway activation in hpv positive and negative penile carcinomas. | the pathogenesis of penile squamous cell carcinoma (pscc) is not well understood, though risk factors include human papillomavirus (hpv). disruption of her/pten/akt pathway is present in many cancers; however there is little information on its function in pscc. we investigated her family receptors and phosphatase and tension homolog (pten) in hpv-positive and negative pscc and its impact on akt activation using immunohistochemistry and fluorescent in situ hybridisation (fish). | 2011 | 21407808 |
| human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines. | human papillomaviruses (hpvs), especially type 16, are implicated in the development of a subset of head and neck squamous cell cancers (hnsccs). this subset of oropharyngeal cancers possesses distinct clinical and laboratory features and outcome, and is particularly common in individuals who lack the traditional risk factors of tobacco and alcohol abuse. moreover, the annual incidence of hpv-related hnsccs has increased in the usa and europe in the last few years. as hpv-associated hnsccs share ... | 2011 | 21403517 |
| human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease. | we investigated coinfection patterns for 25 human papillomavirus (hpv) types and assessed the risk conferred by multiple hpv types toward cervical disease. | 2011 | 21402543 |
| multiple human papillomavirus infections: the exception or the rule? | 2011 | 21402540 | |
| [morphological and immunohistochemical studies of palatine tonsillar hypertrophy in children]. | the paper presents the results of immunohistochemical and morphometric studies conducted to examine an association of the site, the expression of virus antigens, and the nature of morphological changes in the hypertrophic palatine tonsils in children. the distribution of cd3+ and cd20+ cells was explored in tonsillar tissue. the greatest changes were shown in the epithelium, the antigens of herpex simplex virus being more frequently detected than those of human papillomavirus. the presented data ... | 2010 | 21400774 |
| human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis. | whether the oncogenic human papillomavirus (hpv) infection, especially infection with the most common subtypes 16 or 18, is related to prostate carcinogenesis remains conflicting. a meta-analysis with updated data was performed to obtain a more precise estimate of the association between them. | 2011 | 21400096 |
| factors associated with intention to vaccinate a daughter against hpv: a statewide survey in alabama. | human papillomavirus (hpv) is the most common sexually transmitted infection in the united states. adolescent and young adults aged 15-24 were estimated to account for three quarters of new infections in 2000. two hpv vaccines are currently available. the vaccine is recommended for girls aged 11-12 years. previous research has indicated that african-american and asian-american parents are less likely than caucasians to vaccinate their daughters. this investigation examines the relationship betwe ... | 2011 | 21397534 |
| combined promoter methylation analysis of cadm1 and mal: an objective triage tool for high-risk human papillomavirus dna-positive women. | screening women for high-grade cervical intraepithelial neoplasia or cervical cancer (cin3(+)) by high-risk human papillomavirus (hrhpv) testing has as side-effect the detection of hrhpv-positive women without clinically relevant lesions. here, we developed an objective assay assessing the methylation status of the promoter regions of cadm1 and mal to triage hrhpv-positive women for cin3(+). | 2011 | 21389098 |
| the burden of cervical cancer in china: synthesis of the evidence. | the burden of cervical cancer in china has not been characterized in detail. we reviewed cervical cancer data from national mortality surveys and registries, and conducted a meta-analysis to estimate the prevalence of high-grade lesions (hsil) and high-risk human papillomavirus (hr-hpv) infections in rural shanxi province. we found that a national survey in the 1970s estimated age-standardized cervical cancer mortality rates as ôê+15 and ôê+83/100,000 women nationally and in xiangyuan, shanxi; b ... | 2011 | 21387308 |
| mitochondrial c150t polymorphism increases the risk of cervical cancer and hpv infection. | during a survey of control region (d-loop) sequence variances in 142 cervical cancer (cc) patients and 136 controls, all chinese women, including both hpv-positive (human papillomavirus) and hpv-negative subjects, we determined that the c150t polymorphism increased the cc risk in a case-control study (or=3.0, 95% ci=1.8-5.0, p<0.05). hpv-positive individuals were more likely to carry the c150t polymorphism than hpv-negative controls (or=5.8, 95% ci=2.6-13.2, p=2.3+ù10(-5)). hpv-positive cc patie ... | 2011 | 21385627 |
| looking ahead: a case for human papillomavirus testing of self-sampled vaginal specimens as a cervical cancer screening strategy. | even in the era of highly effective human papillomavirus (hpv) prophylactic vaccines, substantial reduction in worldwide cervical cancer mortality will only be realized if effective early detection and treatment of the millions of women already infected and the millions who may not receive vaccination in the next decade can be broadly implemented through sustainable cervical cancer screening programs. effective programs must meet three targets: (i) at least 70% of the targeted population should ... | 2011 | 21384341 |
| cancer vaccine boosted by infrastructure for hiv care in africa. | 2011 | 21383729 | |
| lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | lymphoepithelioma-like carcinoma (lelc) in the urinary tract is a rare malignancy, named for its resemblance to nasopharyngeal undifferentiated carcinoma or lymphoepithelioma. investigation of immunohistochemical and molecular characteristics of bladder lelc is limited. the pathogenesis and biological behavior of these tumors are controversial. | 2011 | 21383609 |
| prevalence of anal intraepithelial neoplasia defined by anal cytology screening and high-resolution anoscopy in a primary care population of hiv-infected men and women. | prevalence of high-grade anal intraepithelial neoplasia, the human papillomavirus-associated putative anal cancer precursor, is high in hiv-infected men who have sex with men, but less is known about its prevalence in other hiv-infected subgroups. similarly, the prevalence of abnormal cytology, used as a screen, is not well-defined in these subgroups. | 2011 | 21383563 |
| update on available vaccines in india: report of the appa vu 2010: i. | the asia pacific pediatric association vaccinology update 2010 was held in mumbai on november 13-14, 2010 to discuss the latest information on burden of infectious diseases, recent developments in vaccines and their impact on immunization practices against infectious diseases occurring in indian children. during the conference the importance of including conjugate haemophilus influenzae type b vaccine and anti-rabies vaccines in routine immunization was stressed. also, the need for giving a seco ... | 2011 | 21373831 |
| human papillomavirus and cervical neoplasia among female sex workers in madagascar. | human papillomavirus (hpv) prevalence and type distribution were estimated among 90 female sex workers (fsws) aged 18 to 58 years in antananarivo, madagascar. | 2010 | 21370602 |
| new indication approved for hpv vaccine. | 2011 | 21370548 | |
| treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the erk1/2 signaling pathway. | numerous epidemiological studies have implicated cigarette smoking as a cofactor in the progression to cervical cancer. tobacco-associated hydrocarbons have been found in cervical mucus, suggesting a possible interaction with human papillomavirus (hpv)-infected cells. the polycyclic aromatic hydrocarbon benzo[a]pyrene (bap) is a major component of cigarette smoke condensate that has received significant attention due to its ability to induce carcinogenesis. we have previously demonstrated by con ... | 2011 | 21367897 |
| performance of p16ink4a immunocytochemistry as a marker of anal squamous intraepithelial lesions. | protein p16(ink4a) immunocytochemistry (iccp16) has the potential to reveal lesions at risk of progression to anal cancer. this study examined measures of diagnostic validity of iccp16 in hiv-positive patients treated at the tropical medicine foundation of amazonas in the coloproctology outpatient clinic. | 2011 | 21365778 |
| human papillomavirus vaccination in males: the state of the science. | human papillomavirus (hpv) is an extremely prevalent sexually transmitted infection that is typically acquired soon after onset of sexual activity. the burden of hpv-related malignant and nonmalignant disease is high in men and women. high-risk or oncogenic types of hpv cause cervical, vaginal, and vulvar cancer in women. these types have also been shown to cause penile cancer in men and a substantial proportion of oropharyngeal and anal malignancy in men and women. low-risk types of hpv cause a ... | 2011 | 21365381 |
| haart and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with hiv. | human immunodeficiency virus (hiv)-seropositive men who have sex with men (msm) are at risk for anal intraepithelial neoplasia (ain) and cancer. the goal of this study was to identify risk factors associated with high-grade ain (ain-2,3) in hiv-positive msm, including the receipt of highly active antiretroviral therapy (haart). | 2011 | 21364075 |
| prevalence of cervical human papillomavirus infection among married women in hanoi, vietnam, 2010. | human papillomavirus (hpv) is a necessary cause of cervical cancer. this study examined the prevalence of cervical hpv infection and the distribution of hpv specific types among married women in hanoi to provide updated data for planning cancer preventive activities. sample of 750 married women aged 15 to 69 years were interviewed and had gynecological examination. hpv infection status and hpv genotyping tests were done for all participants. results: indicated that the prevalence of cervical hpv ... | 2011 | 21362673 |
| epidermal growth factor genetic variation associated with advanced cervical cancer in younger women. | objectives: epidermal growth factor (egf) stimulates cell proliferation by binding to its receptor (epidermal growth factor receptor), and the overexpression of this receptor is associated with poorer prognosis. the egf gene presents a polymorphism at position 61 (a/g), associated with higher egf production. we examined the association between this polymorphism and cervical cancer through a case-control study. methods: this study used the pcr-restriction fragment length polymorphism method on a ... | 2011 | 21358296 |
| for cancers caused by hpv, two vaccines were just the beginning. | 2011 | 21357595 | |
| clinical experience with the cervista hpv hr assay: correlation of cytology and hpv status from 56,501 specimens. | testing for high-risk (hr) human papillomavirus (hpv) is a key component of current recommendations for cervical cancer screening. herein is described our clinical experience using cervista hpv hr, a testing platform recently approved by the us food and drug administration for clinical use. using data from a high-volume commercial laboratory, a retrospective analysis of cytologic and cervista hpv hr test results from 56,501 samples was performed, and an indirect comparison was made with previous ... | 2011 | 21354050 |
| immortalisation of normal human urothelial cells compromises differentiation capacity. | the development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. although tumour grade is an independent prognostic marker for urothelial carcinoma (uc), the molecular events underpinning the loss of urothelial differentiation are poorly understood. | 2011 | 21353380 |
| human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma. | 2011 | 21352537 | |
| oral zinc sulfate treatment for viral warts: an open-label study. | viral warts, which are caused by the human papilloma virus, are a common problem in dermatology. various modalities have been used to treat warts, but none are uniformly effective or directly antiviral. recent studies show that oral zinc sulfate could be effective in the treatment of viral warts. thirty-one patients with multiple, non-genital viral warts were recruited in this open-label clinical study. the patients were treated with oral zinc sulfate (10 mg/kg to a maximum dose of 600 mg/day) f ... | 2010 | 21352302 |
| self-collected human papillomavirus testing acceptability: comparison of two self-sampling modalities. | human papillomavirus (hpv) testing can be used as a primary test for cervical cancer screening. hpv self-sampling has the potential to replace physician/nurse sampling. our objective was to compare the acceptability of two self-sampling methods among 205 women undergoing an excisional procedure for cervical intraepithelial neoplasia (cin) at the european institute of oncology (ieo). | 2011 | 21351869 |
| potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts. | the p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (hpv). the hpv e6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. in our study, we attempted to improve the clinical outcomes of this combined therapy by modifying the p53-targeted adenovirus to become radiation-responsive. the antitumor adenovirus was constructed by inserting a radiat ... | 2011 | 21351100 |
| high-risk human papillomavirus testing in women with asc-us cytology: results from the athena hpv study. | this study evaluated the clinical performance of the cobas 4800 hpv test (roche molecular systems, pleasanton, ca) for high-risk human papillomavirus (hr-hpv) testing with individual hpv-16/hpv-18 genotyping in women 21 years or older with atypical squamous cells of undetermined significance (asc-us). women (n = 47,208) were recruited in the united states during routine screening, and liquid-based cytology and hpv testing were performed. the asc-us prevalence was 4.1% (1,923/47,208), and 1,578 w ... | 2011 | 21350104 |
| completion of the human papillomavirus vaccine series in females attending an urban immunization clinic. | this project characterized the extent to which women and girls who initiated human papillomavirus vaccination between 2007 and 2009 at the baltimore city health department completed the full vaccine series, and reasons for failure to follow-up. more than 85% of girls and women had an incomplete series, and it was not possible to reach 80% of these girls and women using the phone number provided. those who were contacted reported not knowing they needed further doses, having forgotten, being too ... | 2011 | 21343841 |
| molecular detection of cytomegalovirus, herpes simplex virus 2, human papillomavirus 16-18 in turkish pregnants. | human cytomegalovirus (cmv) is the most common cause of viral intrauterine infections in the world. herpes simplex virus type 2 (hsv-2) and human papillomavirus (hpv) are the main agents of viral sexually transmitted diseases, which cause genital ulcers and genital warts, respectively. hpv infection has been linked to the majority of the anogenital malignancies. the aim of this study was to detect the existence of cmv, hsv-2 and hpv type 16-18 in turkish pregnants by using sensitive molecular as ... | 2010 | 21340297 |
| human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and african americans. | to evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in african americans and whites and to examine patient outcomes in these 2 groups. | 2011 | 21339403 |
| assessing the role of education on turkish university students' knowledge about hpv and related diseases. | human papillomavirus (hpv) is one of the most common sexually transmitted causes of infections and adolescents are at high risk. the aim of the study was to evaluate university students' hpv knowledge before and after educational intervention on hpv. | 2010 | 21338219 |