Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis. | to determine the incidence and predisposing factors for severe bronchiolitis in previously healthy term infants <12 months of age experiencing their first episode of bronchiolitis. | 2011 | 21284715 |
| palivizumab for immunoprophylaxis of respiratory syncytial virus (rsv) bronchiolitis in high-risk infants and young children: a systematic review and additional economic modelling of subgroup analyses. | respiratory syncytial virus (rsv) is a seasonal infectious disease, with epidemics occurring annually from october to march in the uk. it is a very common infection in infants and young children and can lead to hospitalisation, particularly in those who are premature or who have chronic lung disease (cld) or congenital heart disease (chd). palivizumab (synagis®, medimmune) is a monoclonal antibody designed to provide passive immunity against rsv and thereby prevent or reduce the severity of rsv ... | 2011 | 21281564 |
| rig-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type i ifn-dependent mechanism. | vascular endothelial growth factor (vegf) regulates vascular, inflammatory, remodeling, and cell death responses. it plays a critical role in normal pulmonary physiology, and vegf excess and deficiency have been implicated in the pathogenesis of asthma and chronic obstructive pulmonary disease, respectively. although viruses are an important cause of chronic obstructive pulmonary disease exacerbations and innate responses play an important role in these exacerbations, the effects of antiviral re ... | 2011 | 21278304 |
| rapid testing for respiratory syncytial virus in a paediatric emergency department: benefits for infection control and bed management. | respiratory syncytial virus (rsv) is responsible for annual winter outbreaks of respiratory tract infection among children in temperate climates, placing severe pressure on hospital beds. cohorting of affected infants has been demonstrated to be an effective strategy in reducing nosocomial transmission of rsv, and may keep cubicles free for other patients who require them. testing of symptomatic children for rsv is standard practice, but unfortunately traditional laboratory testing is not rapid ... | 2011 | 21277648 |
| cytokines profile and acute bronchiolitis. | 2011 | 21277459 | |
| development and evaluation of a luminex multiplex serology assay to detect antibodies to bovine herpes virus 1, parainfluenza 3 virus, bovine viral diarrhoea virus, and bovine respiratory syncytial virus, with comparison to existing elisa detection methods. | detection of circulating antibodies to bovine herpes virus 1 (bhv-1), parainfluenza 3 virus (pi3v), bovine viral diarrhoea virus (bvdv) and bovine respiratory syncytial virus (brsv) using elisa is widely used for veterinary diagnostics and surveillance. in this paper, the potential of a multiplex serology test based on luminex technology, where all antibodies are simultaneously detected in a single assay was investigated. the performance of "in-house" separate elisas which use relatively crude l ... | 2011 | 21277304 |
| [clusters of respiratory tract infections and alert strategy in nursing homes]. | outbreaks of acute respiratory infections (ari) are common in institutions for elderly people. we had for objective to investigate clusters of cases (lower respiratory tract infection and influenza-like illness [lrti/ili]) in order to improve and validate alert strategies in these institutions. | 2011 | 21277131 |
| the multicenter italian birth cohort study on incidence and determinants of lower respiratory tract infection hospitalization in infants at 33 weeks ga or more: preliminary results. | respiratory syncytial virus (rsv) causes respiratory infections during the first year of life. very premature infants have more severe diseases and also 'late preterm infants' may be more susceptible to the infection. | 2011 | 21277122 |
| are late preterm infants as susceptible to rsv infection as full term infants? | preterm infants are at increased risk of being rehospitalised during the first few months of life with severe respiratory syncytial virus (rsv) lower respiratory tract infection (lrti) that usually manifests as apnea and hypoxemia. this occurs more commonly in preterm infants < 33 weeks gestational age (ga), but recent studies demonstrate that late preterm infants (those born between 34 weeks and 0 days to 36 weeks and 6 days ga) are equally susceptible to rsv lrti as those with lower ga. factor ... | 2011 | 21276672 |
| oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (rsv): consequences of deficient interferon-dependent antiviral defense. | oncolytic virotherapy for cancer treatment utilizes viruses for selective infection and death of cancer cells without any adverse effect on normal cells. we previously reported that the human respiratory syncytial virus (rsv) is a novel oncolytic virus against androgen-independent pc-3 human prostate cancer cells. the present study extends the result to androgen-dependent prostate cancer, and explores the underlying mechanism that triggers rsv-induced oncolysis of prostate cancer cells. | 2011 | 21276246 |
| special populations: do we need evidence from randomized controlled trials to support the need for respiratory syncytial virus prophylaxis? | congenital abnormalities and impaired mechanisms that govern the normal coordinated physiology of breathing, sucking, swallowing and airway clearance, place infants with underlying medical disorders at high risk for respiratory morbidity following respiratory syncytial virus (rsv) lower respiratory tract infection. the use of rsv prophylaxis in premature infants' = 35 weeks gestational age, infants with chronic lung and hemodynamically significant heart disease is firmly established through rand ... | 2011 | 21273012 |
| differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells. | human respiratory syncytial virus (rsv) causes severe respiratory disease in infants. airway epithelial cells are the principle targets of rsv infection. however, the mechanisms by which it causes disease are poorly understood. most rsv pathogenesis data are derived using laboratory-adapted prototypic strains. we hypothesized that such strains may be poorly representative of recent clinical isolates in terms of virus/host interactions in primary human bronchial epithelial cells (pbecs). | 2011 | 21272337 |
| [frequency of respiratory viruses and clinical characteristics in children attending a care center in mexico city]. | to describe the frequency of respiratory viruses and clinical characteristics in children with respiratory signs and symptoms in a tertiary care center in mexico. | 2010 | 21271012 |
| simultaneous detection of influenza a, influenza b, and respiratory syncytial viruses and subtyping of influenza a h3n2 virus and h1n1 (2009) virus by multiplex real-time pcr. | a multiplex real-time pcr assay was developed to simultaneously detect and discriminate influenza a virus subtypes, including novel h1n1 (2009) and seasonal h3n2 virus, influenza b virus, and respiratory syncytial virus (rsv) in a single test tube, with detection sensitivity and specificity of 99% and 100%, respectively, for the four pathogens. | 2011 | 21270233 |
| epidemiological and phylogenic study of human metapneumovirus infections during three consecutive outbreaks in normandy, france. | human metapneumovirus (hmpv) is responsible for respiratory tract disease, particularly in the young and elderly population. an epidemiological and phylogenic study was performed on children admitted to hospital with an acute lower respiratory tract infection (lri). data were obtained and analyzed over three consecutive winters, from 2002-2003 to 2004-2005. each year during the winter period, from november to march, 2,415 nasal swabs were tested by a direct immunofluorescence assay (dfa) for inf ... | 2011 | 21264874 |
| impact of rotavirus vaccination on hospital-acquired rotavirus gastroenteritis in children. | data show that after the implementation of routine rotavirus vaccination for infants in the united states, community-acquired (ca) rotavirus cases declined substantially in the 2007-2008 season. the impact of community-based rotavirus vaccination on the substantial burden of hospital-acquired (ha) rotavirus has not been documented. | 2011 | 21262887 |
| viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months. | respiratory infections are a leading cause of pediatric hospitalizations. this study investigated whether virus-virus or virus-bordetella co-infections are more frequent or more severe than previously recognized. | 2011 | 21262758 |
| prevalence of pasteurella multocida and other respiratory pathogens in the nasal tract of scottish calves. | the prevalence of pasteurella multocida, a cause of bovine respiratory disease, was studied in a random sample of beef suckler and dairy farms throughout scotland, by means of a cross-sectional survey. a total of 637 calves from 68 farms from six geographical regions of scotland were sampled between february and june 2008. deep nasal swabs were taken, and samples that were culture-positive for p multocida were confirmed by pcr. prevalence of p multocida was 17 per cent (105 of 616 calves); 47 pe ... | 2010 | 21257416 |
| rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by rt-pcr and electrospray ionization mass spectrometry. | diagnosis of the etiologic agent of respiratory viral infection relies traditionally on culture or antigen detection. this pilot evaluation compared performance characteristics of the rt-pcr and electrospray ionization mass spectrometry (rt-pcr/esi-ms) platform to conventional virologic methods for identifying multiple clinically relevant respiratory viruses in nasopharyngeal aspirates. the rt-pcr/esi-ms respiratory virus surveillance kit was designed to detect respiratory syncytial virus, influ ... | 2011 | 21256867 |
| regulation of stat signaling in mouse bone marrow derived dendritic cells by respiratory syncytial virus. | dendritic cells (dcs) act as a portal for virus invasion as well as potent antigen-presenting cells (apcs) involved in the antiviral host response. interferons (ifns) are produced in response to bacterial and viral infection and activate innate immune responses to efficiently counteract and remove pathogenic invaders. respiratory syncytial virus (rsv) could inhibit ifn-mediated signaling pathway in epithelial cells; however, the effects of rsv on ifn signaling in the dendritic cells (dcs) are st ... | 2011 | 21255624 |
| ltb4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects. | leukotriene b4 (ltb4) recruits and activates neutrophils. accordingly, this leukotriene is involved in innate defense actions. | 2011 | 21251805 |
| reverse transcription polymerase chain reaction and electrospray ionization mass spectrometry for identifying acute viral upper respiratory tract infections. | diagnosis of respiratory viruses traditionally relies on culture or antigen detection. we aimed to demonstrate capacity of the reverse transcription polymerase chain reaction/electrospray ionization mass spectrometry (rt-pcr/esi-ms) platform to identify clinical relevant respiratory viruses in nasopharyngeal aspirate (npa) samples and compare the diagnostic performance characteristics relative to conventional culture- and antigen-based methods. an rt-pcr/esi-ms respiratory virus surveillance kit ... | 2011 | 21251562 |
| withdrawn: inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing. | acute bronchiolitis in infants and young children is associated with long-term airway disease also known as post-bronchiolitic wheezing. two major hypotheses have been proposed to explain the association between bronchiolitis and pbw. the first hypothesis considers bronchiolitis to be the first manifestation of recurrent wheezing in infants and children who are susceptible to obstructive airway disease. the second hypothesis suggests that the infection and concomitant inflammatory reaction in th ... | 2011 | 21249665 |
| the cellular endosomal sorting complex required for transport pathway is not involved in avian metapneumovirus budding in a virus-like-particle expression system. | avian metapneumovirus (ampv) is a paramyxovirus that principally causes respiratory disease and egg production drops in turkeys and chickens. together with its closely related human metapneumovirus (hmpv), they comprise the genus metapneumovirus in the family paramyxoviridae. little is currently known about the mechanisms involved in the budding of metapneumovirus. by using ampv as a model system, we showed that the matrix (m) protein by itself was insufficient to form virus-like-particles (vlps ... | 2011 | 21248175 |
| respiratory syncytial virus infection. | 2011 | 21243989 | |
| respiratory syncytial virus infection in children. | respiratory syncytial virus (rsv) is an rna virus that causes respiratory tract infections in children. in the north- ern hemisphere, the peak infection season is november through april. by two years of age, most children will have had an rsv infection. bronchiolitis, a lower respiratory tract infection, is often caused by rsv. an rsv infection is diagnosed based on patient history and physical examination. children typically present with cough, coryza, and wheezing. laboratory testing and chest ... | 2011 | 21243988 |
| adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in shaanxi province, china. | pneumonia caused by adenovirus infection is usually severe especially with adenovirus serotype 7 commonly associated with lower respiratory tract disease outbreaks. we reported an outbreak of 70 cases of severe pneumonia with one death of infants in shaanxi province, china. sampling showed adenovirus 7 (ad7) as the primary pathogen with some co-infections. | 2011 | 21241515 |
| synthesis of new c5-(1-substituted-1,2,3-triazol-4 or 5-yl)-2'-deoxyuridines and their antiviral evaluation. | the synthesis and antiviral evaluation of a series of c5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. the key steps of this synthesis are regioselective huisgen's 1,3-dipolar cycloaddition, using either copper-catalyzed azide-alkyne cycloaddition (cuaac) or ruthenium-catalyzed azide-alkyne cycloaddition (ruaac) under microwave activation. some compounds among the 5a-l series possess activity against herpes simplex viruses 1 and 2, varicella-zoster virus, human ... | 2010 | 21232828 |
| recombinant sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus. | cell entry by paramyxoviruses requires fusion between viral and cellular membranes. paramyxovirus infection also gives rise to the formation of multinuclear, fused cells (syncytia). both types of fusion are mediated by the viral fusion (f) protein, which requires proteolytic processing at a basic cleavage site in order to be active for fusion. in common with most paramyxoviruses, fusion mediated by sendai virus f protein (f(sev)) requires coexpression of the homologous attachment (hemagglutinin- ... | 2011 | 21228237 |
| correlations between clinical illness, respiratory virus infections and climate factors in a tropical paediatric population. | summaryweekly (august 2003âdecember 2008) numbers of five common paediatric diseases and the incidence of respiratory viruses were obtained from a children's hospital in singapore and correlated with climate data using multivariate time-series techniques. upper respiratory tract infections were positively correlated with the incidences of influenza a, b, respiratory syncytial virus (rsv) and parainfluenza viruses (types 1â3 combined). lower respiratory tract infections were positively correl ... | 2011 | 21226981 |
| beyond the influenza-like illness surveillance: the need for real-time virological data. | 2011 | 21223833 | |
| the value of budget impact analyses in evaluating targeted therapies-the case of rsv prophylaxis for preterm infants. | 2011 | 21211503 | |
| concomitant bacterial pneumonia and empirical antibiotics in severe respiratory syncytial virus infection. | 2011 | 21209581 | |
| analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab. | palivizumab is a us food and drug administration-approved monoclonal antibody for the prevention of respiratory syncytial virus (rsv) lower respiratory disease in high-risk infants. motavizumab, derived from palivizumab with enhanced antiviral activity, has recently been tested in humans. although palivizumab escape mutants have been generated in the laboratory, the development of resistant rsv in patients receiving palivizumab has not been reported previously. | 2011 | 21208913 |
| oral ribavirin therapy for lower respiratory tract infection of respiratory syncytial virus complicating bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. | 2011 | 21207211 | |
| myocarditis in the setting of rsv bronchiolitis. | myocarditis in the pediatric population is commonly caused by viral pathogens, notably entero virus and adeno virus. respiratory syncytial virus, although widespread among this population, is rarely associated with myocarditis. the incidence of myocarditis is unknown due to the variability of clinical presentation and diagnostic limitations. data regarding prognosis is lacking in children. patients should be monitored in a pediatric intensive care unit secondary to the risk of hemodynamic compro ... | 2011 | 21204669 |
| temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children. | mucosal coinfections with respiratory viruses and streptococcus pneumoniae are common, but the role of rhinovirus infections in the development of invasive pneumococcal disease (ipd) in children has not been studied. | 2011 | 21200362 |
| mortality and morbidity among infants at high risk receiving prophylaxis with palivizumab: a systematic literature review and meta-analysis. | objectives:: a systematic literature review and meta-analysis was performed to evaluate the impact of prophylaxis with palivizumab on mortality and morbidity associated with respiratory syncytial virus infection in infants at high risk (≤35 wks of gestational age, chronic lung disease, or congenital heart disease). data sources:: medline, embase, and current contents were used. medline was searched from january 1, 1990 to may 16, 2007. the bibliographies of accepted studies and recent reviews an ... | 2010 | 21200358 |
| biological challenges and technological opportunities for respiratory syncytial virus vaccine development. | respiratory syncytial virus (rsv) is an important cause of respiratory disease causing high rates of hospitalizations in infants, significant morbidity in children and adults, and excess mortality in the elderly. major barriers to vaccine development include early age of rsv infection, capacity of rsv to evade innate immunity, failure of rsv-induced adaptive immunity to prevent reinfection, history of rsv vaccine-enhanced disease, and lack of an animal model fully permissive to human rsv infecti ... | 2011 | 21198670 |
| a rhoa-derived peptide inhibits human immunodeficiency virus-1 entry in vitro. | rhoa-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. the present study investigates the toxicity, anti-hiv-1 activity and mechanism of action of a rhoa-derived peptide (rhoa 77-95). the efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and enfuvirtide, a hiv entry inhibitor. our data show that this rhoa-derived peptide is a non-toxic and effective inhibitor of ... | 2011 | 21198428 |
| local cytokine response upon respiratory syncytial virus infection. | respiratory syncytial virus (rsv) is the leading cause of childhood hospitalization and respiratory distress and has been recognized for several decades as a major health and economic burden worldwide. this virus has developed several virulence mechanisms to impair the establishment of a protective immune response to re-infection. accordingly, inefficient immunological memory is usually generated after exposure to this pathogen. furthermore, it has been shown that rsv can actively promote the in ... | 2010 | 21195729 |
| immunologic impact of nutrient depletion in chronic obstructive pulmonary disease. | chronic obstructive pulmonary disease (copd) is characterized by small airways, alveolar and systemic inflammation and remodeling causing airflow limitation and parenchymal destruction. mechanisms of oxidative stress include exposure to cigarette smoke and environmental stimuli that activate proinflammatory responses, stimulate alveolar neutrophils and macrophages and lead to apoptosis of endothelial and epithelial cells. copd may have origins in fetal and neonatal factors that affect intrauteri ... | 2011 | 21194406 |
| assessment of ige response and cytokine gene expression in pulmonary efferent lymph collected after ovalbumin inhalation during experimental infection of calves with bovine respiratory syncytial virus. | to assess ige response and cytokine gene expressions in pulmonary lymph collected from bovine respiratory syncytial virus (brsv)-infected calves after ovalbumin inhalation. | 2011 | 21194346 |
| pulmonary surfactant in respiratory syncytial virus bronchiolitis: the role in pathogenesis and clinical implications. | respiratory syncytial virus (rsv) bronchiolitis is the leading cause of lower respiratory tract infection, and the most frequent reason for hospitalization among infants throughout the world. in addition to the acute consequences of the disease, rsv bronchiolitis in early childhood is related to further development of recurrent wheezing and asthma. despite the medical and economic burden of the disease, therapeutic options are limited to supportive measures, and mechanical ventilation in severe ... | 2010 | 21194166 |
| respiratory outcomes, utilization and costs 12 months following a respiratory syncytial virus diagnosis among commercially insured late-preterm infants. | to determine, among a commercially-insured population of late-preterm infants, utilization of healthcare resources and costs during the 1 year following a diagnosis of respiratory syncytial virus lower respiratory infection (rsv lri). | 2010 | 21192761 |
| decreased serum antibody responses to recombinant pneumocystis antigens in hiv-infected and uninfected current smokers. | serologic studies can provide important insights into the epidemiology and transmission of pneumocystis jirovecii. exposure to p. jirovecii can be assessed by serum antibody responses to recombinant antigens from the major surface glycoprotein (msgc), although factors that influence the magnitude of the antibody response are incompletely understood. we determined the magnitudes of antibody responses to p. jirovecii in comparison to adenovirus and respiratory syncytial virus (rsv) in hiv-infected ... | 2010 | 21191078 |
| respiratory syncytial virus represses glucocorticoid receptor-mediated gene activation. | respiratory syncytial virus (rsv) is a common cause of bronchiolitis in infants. although antiinflammatory in nature, glucocorticoids have been shown to be ineffective in the treatment of rsv-induced bronchiolitis and wheezing. in addition, the effectiveness of glucocorticoids at inhibiting rsv-induced proinflammatory cytokine production in cell culture has been questioned. in this study, we have investigated the effect of rsv infection on glucocorticoid-induced gene activation in lung epitheliu ... | 2010 | 21190962 |
| clinical prediction rule for rsv bronchiolitis in healthy newborns: prognostic birth cohort study. | our goal was to determine predictors of respiratory syncytial virus (rsv) lower respiratory tract infection (lrti) among healthy newborns. | 2010 | 21187309 |
| [respiratory syncytial virus infection enhances airway hyperresponsiveness in guinea pigs and the underlined mechanism]. | to study the relation between respiratory syncytial virus infection and asthma development by measuring airway responsiveness (ar) and m2r function. | 2009 | 21186634 |
| aik-c measles vaccine expressing fusion protein of respiratory syncytial virus induces protective antibodies in cotton rats. | respiratory syncytial virus (rsv) is the most common cause of respiratory infection in infants, and no vaccine is available. in this report, recombinant aik-c measles vaccines, expressing the rsv g or f protein of subgroup a (mvaik/rsv/g or f), were investigated as a rsv vaccine candidate. mvaik/rsv/g or f had the original ts phenotype and expressed rsv/g or f protein. cross-reactive neutralizing antibodies against rsv subgroups a and b were detected in cotton rats immunized intramuscularly with ... | 2010 | 21185852 |
| molecular epidemiology of human respiratory syncytial virus subgroups a and b identified in adults with hematological malignancy attending an irish hospital between 2004 and 2009. | human respiratory syncytial virus (hrsv) is an important cause of respiratory infection in patients with hematological malignancy, particularly hematopoietic stem cell transplant recipients. this study investigated the genetic variability of the attachment (g) protein gene among hrsv isolates collected from adult patients with hematological malignancy. between december 2004 and march 2009, 60 samples collected from 58 adults attending an irish hospital were positive for hrsv by direct immunofluo ... | 2011 | 21181932 |
| [effect of qingkailing injection on children with respiratory syncytial virus pneumonia of phlegm-heat obstructing fei syndrome pattern at different time-points]. | to evaluate the curative effect of qingkailing injection (qkl) for treatment of children's respiratory syncytial virus pneumonia of phlegm-heat obstructing fei syndrome pattern (svp-ph) depending upon main symptom assessment. | 2010 | 21180082 |
| evaluation of the 3m rapid detection test for respiratory syncytial virus (rsv) in children during the early stages of the 2009 rsv season. | we report the results of the 3m rapid detection respiratory syncytial virus (rsv) assay. this study includes pediatric patient results from nasopharyngeal swabs submitted from october to december 2009. there was a sensitivity of 74% and specificity approaching 100% compared to the pcr-based xtag respiratory viral panel. | 2010 | 21177903 |
| high frequency of repeated infections due to emerging genotypes of human respiratory syncytial viruses among children during eight successive epidemic seasons in japan. | in eight successive seasons (2001 to 2009), a total of 726 human respiratory syncytial virus (hrsv) infections from a total of 1,560 children with acute lower respiratory tract illness were identified. molecular analysis of the attachment (g) protein gene confirmed that 52 (7.8%) children were infected more than once with any of the 3 genotypes of hrsv-a (genotypes ga5, na1, and na2) and/or 6 genotypes of hrsv-b (genotypes ba4, ba5, and ba7 to ba10). repeated infections in 46 cases (82.1%) occur ... | 2010 | 21177891 |
| [a pathogenic and clinical study of 882 cases of adult influenza-like illness in guangzhou]. | this study was undertaken to describe the viral etiology and clinical features in patients with influenza-like illness (ili) in guangzhou. | 2010 | 21176504 |
| c-terminal tyrosine residues modulate the fusion activity of the hendra virus fusion protein. | the paramyxovirus family includes important human pathogens such as measles, mumps, respiratory syncytial virus, and the recently emerged, highly pathogenic hendra and nipah viruses. the viral fusion (f) protein plays critical roles in infection, promoting both the virus-cell membrane fusion events needed for viral entry as well as cell-cell fusion events leading to syncytia formation. we describe the surprising finding that addition of the short epitope ha tag to the cytoplasmic tail (ct) of th ... | 2011 | 21175223 |
| the impact of prophylaxis on paediatric intensive care unit admissions for rsv infection: a retrospective, single-centre study. | respiratory syncytial virus (rsv) is the leading cause of lower respiratory tract infections and hospitalizations in children aged <2 years. the aim of this retrospective, single-centre study was to examine the characteristics of patients admitted to a paediatric intensive care unit (picu) with rsv infection following the implementation of a rsv prophylaxis programme. electronic hospital medical records of all picu admissions for rsv infection were searched from 2003 to 2009. data on baseline de ... | 2010 | 21174120 |
| respiratory syncytial virus disease: update on treatment and prevention. | respiratory syncytial virus (rsv) is the leading cause of acute lower respiratory tract infections in infants and young children, accounting for more than 100,000 hospitalizations per year in the usa. the majority of hospitalizations occur in infants less than 1 year of age. worldwide, rsv is associated with an annual mortality rate of 160,000-600,000 deaths. premature infants, and infants with congenital heart disease, neuromuscular disease, structural airway abnormalities and immunodeficiencie ... | 2011 | 21171875 |
| serum sp-d levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis. | to evaluate whether sp-d concentration is a useful biomarker of the severity of respiratory syncytial virus (rsv) bronchiolitis, we determined sp-d concentrations in patients with rsv bronchiolitis with or without chronic heart disease. we enrolled 52 patients who had been diagnosed with rsv bronchiolitis and required admission to the hospital at the department of pediatrics of fukushima medical university school of medicine from 2004 through 2005. these patients were divided into two groups: gr ... | 2010 | 21171185 |
| performance of a rapid antigen test (binax now® rsv) for diagnosis of respiratory syncytial virus compared with real-time polymerase chain reaction in a pediatric population. | infants from alaska's yukon-kuskokwim delta (ykd) have a high respiratory syncytial virus (rsv) hospitalization rate (104/1000/yr). appropriate patient management requires rapid and accurate rsv diagnosis. antigen-based methods are often used in clinical settings, but these tests can lack sensitivity. | 2010 | 21163694 |
| serum sp-d levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis. | to evaluate whether sp-d concentration is a useful biomarker of the severity of respiratory syncytial virus (rsv) bronchiolitis, we determined sp-d concentrations in patients with rsv bronchiolitis with or without chronic heart disease. we enrolled 52 patients who had been diagnosed with rsv bronchiolitis and required admission to the hospital at the department of pediatrics of fukushima medical university school of medicine from 2004 through 2005. these patients were divided into two groups: gr ... | 2010 | 21154623 |
| health-related quality of life in preschool children in five health conditions. | to test the responsiveness of the infant/toddler quality of life questionnaire (itqol) to five health conditions. in addition, to evaluate the impact of the child's age and gender on the itqol domain scores. | 2010 | 21153564 |
| the burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural thailand. | we describe the epidemiology of hospitalized rsv infections for all age groups from population-based surveillance in two rural provinces in thailand. | 2010 | 21152047 |
| rsv-induced bronchial epithelial cell pd-l1 expression inhibits cd8+ t cell nonspecific antiviral activity. | respiratory syncytial virus (rsv) is a major cause of bronchiolitis in infants. it is also responsible for high morbidity and mortality in the elderly. programmed death ligands (pd-ls) on antigen-presenting cells interact with receptors on t cells to regulate immune responses. the programmed death receptor-ligand 1/programmed death receptor 1 (pd-l1-pd-1) pathway is inhibitory in chronic viral infections, but its role in acute viral infections is unclear. we hypothesized that bronchial epithelia ... | 2011 | 21148500 |
| antiviral and lung protective activity of a novel rsv fusion inhibitor in a mouse model. | respiratory syncytial virus (rsv) causes bronchiolitis in young children and common colds in adults. there is no licensed vaccine, and prophylactic treatment with palivizumab is very expensive and limited to high risk infants. ribavirin is used as an antiviral treatment in infants and immunosuppressed patients, and its use is limited due to side effects, toxicity to the recipient and staff and evidence of marginal clinical efficacy. we therefore studied the in vivo kinetics, antiviral and protec ... | 2010 | 21148224 |
| influence of lipids on the interfacial disposition of respiratory syncytical virus matrix protein. | the propensity of a matrix protein from an enveloped virus of the mononegavirales family to associate with lipids representative of the viral envelope has been determined using label-free methods, including tensiometry and brewster angle microscopy on lipid films at the air-water interface and atomic force microscopy on monolayers transferred to ots-treated silicon wafers. this has enabled factors that influence the disposition of the protein with respect to the lipid interface to be characteriz ... | 2010 | 21141948 |
| management of rsv infections in adult recipients of hematopoietic stem cell transplantation. | respiratory syncytial virus (rsv) is a common cause of seasonal respiratory viral infection in patients who have undergone hematopoietic stem cell transplantation. rsv usually presents as an upper respiratory tract infection in this patient population but may progress rapidly to lower respiratory tract infection. available therapies that have been used for the treatment of rsv infections are limited to ribavirin, intravenous immunoglobulin, and palivizumab. the use of aerosolized ribavirin, alon ... | 2010 | 21139081 |
| the use of a neonatal mouse model to study respiratory syncytial virus infections. | respiratory syncytial virus (rsv) infection is the most significant cause of viral death in infants worldwide. the significant morbidity and mortality associated with this disease underscores the urgent need for the development of an rsv vaccine. the development of an rsv vaccine has been hampered by our limited understanding of the human host immune system, which plays a significant role in rsv pathogenesis, susceptibility and vaccine efficacy. as a result, animal models have been developed to ... | 2010 | 21133663 |
| [etiology of community acquired pneumonia in children 2-59 months old in two ecologically different communities from peru]. | community acquired pneumonia (cap) is a major public health problem, being the most affected the pediatric population. the aim of this study was to compare the etiology, clinical and radiological features of cap in under- five-year-old children. | 2010 | 21132248 |
| hospitalizations due to respiratory syncytial virus in children with congenital malformations. | statewide respiratory syncytial virus (rsv) lower respiratory tract infection hospitalization data of colorado children with congenital malformations was used to estimate the population-based risk and severity of disease of rsv hospitalizations. spina bifida without anencephaly, cleft palate, lung agenesis or dysgenesis, and biliary atresia were associated with a higher risk of being hospitalized with rsv lower respiratory tract infection and an increased severity of disease when hospitalized. | 2011 | 21127456 |
| time series model to predict burden of viral respiratory illness on a pediatric intensive care unit. | in the united states, viral respiratory infections are a leading cause of illness and hospitalization in young children. caring for children with severe viral respiratory illness can have a substantial impact on resource utilization in the pediatric intensive care unit (picu). the objective was to build a robust model that captures the periodicity of severe pediatric viral respiratory illness and forecasts the incidence of viral respiratory illness in the picu. | 2010 | 21127319 |
| effects of human respiratory syncytial virus, metapneumovirus, parainfluenza virus 3 and influenza virus on cd4+ t cell activation by dendritic cells. | background: human respiratory syncytial virus (hrsv), and to a lesser extent human metapneumovirus (hmpv) and human parainfluenza virus type 3 (hpiv3), re-infect symptomatically throughout life without antigenic change, suggestive of incomplete immunity. one causative factor is thought to be viral interference with dendritic cell (dc)-mediated stimulation of cd4+ t cells. methodology, principal findings: we infected human monocyte-derived dc with purified hrsv, hmpv, hpiv3, or influenza a virus ... | 2010 | 21124776 |
| respiratory watch: development of a provincial system for respiratory syncytial virus surveillance in nova scotia, 2005-2008. | respiratory syncytial virus (rsv) is the most common cause of severe lower respiratory tract infection in young children and is increasingly recognized as a cause of influenza-like illness in those older than 65 years of age. a surveillance system to provide timely local information about rsv activity in nova scotia (ns) is described. | 2009 | 21119793 |
| t cell receptor clonotype influences epitope hierarchy in the cd8+ t cell response to respiratory syncytial virus infection. | cd8+ t cell responses are important for recognizing and resolving viral infections. to better understand the selection and hierarchy of virus-specific t cell responses, we compared the t cell receptor (tcr) clonotype in parent and hybrid strains of respiratory syncytial virus-infected mice. k(d)m2(82-90) (syigsinni) in balb/c and d(b)m(187-195) (naitnakii) in c57bl/6 are both dominant epitopes in parent strains but assume a distinct hierarchy, with k(d)m2(82-90) dominant to d(b)m(187-195) in hyb ... | 2010 | 21118816 |
| simultaneous detection and differentiation of respiratory syncytial virus and other respiratory viral pathogens. | rapid and accurate detection of respiratory syncytial virus (rsv) provides pathogen-specific diagnosis, allows implementation of appropriate infection control measures, and improves patient management. one diagnostic challenge is that respiratory infections, which can be caused by several viral pathogens including rsv, usually present with similar signs and symptoms that are nearly indistinguishable by clinical diagnosis. we have described in the chapter a rapid, high-throughput laboratory techn ... | 2011 | 21116808 |
| childhood pneumonia: a neglected, climate-sensitive disease? | 2010 | 21111894 | |
| detection of respiratory syncytial virus using nanoparticle amplified immuno-polymerase chain reaction. | in traditional immuno-polymerase chain reaction (immuno-pcr), a single antibody recognition event is associated with one to three dna tags, which are subsequently amplified by pcr. here we describe a nanoparticle-amplified immuno-pcr (npa-ipcr) assay that combines antibody recognition of enzyme-linked immunosorbent assay (elisa) with a 50-fold nanoparticle valence amplification step prior to tag amplification by pcr. the assay detects a respiratory syncytial virus (rsv) surface protein using an ... | 2010 | 21111702 |
| [research on the methods for titrating respiratory syncytial virus]. | respiratory syncytial virus (rsv) is the most common cause of lower respiratory infection in infants. it is very important to quantitative assay of rsv titer in the study on rsv pathogenesis, candidate vaccine and antiviral treatment. therefore, we develop real-time quantitative pcr (q-pcr) assay and enzyme immunospots (eis) for titrating rsv and compare them with traditional 50% tissue culture infectious doses (tcid50). | 2010 | 21110441 |
| [experimental research on anti-respiratory syncytial virus effect in vitro of earthworm coelomic fluid]. | to explore the antivirus function in vitro of earthworm coelomic fluid (ecf) by researching its effect on inhibiting respiratory syncytial virus (rsv). | 2010 | 21110430 |
| quantitative proteomic analysis of a549 cells infected with human respiratory syncytial virus subgroup b using silac coupled to lc-ms/ms. | human respiratory syncytial virus (hrsv) is a leading cause of serious lower respiratory tract infections in infants. the virus has two subgroups a and b, which differ in prevalence and (nucleotide) sequence. the interaction of subgroup a viruses with the host cell is relatively well characterized, whereas for subgroup b viruses it is not. therefore quantitative proteomics was used to investigate the interaction of subgroup b viruses with a549 cells, a respiratory cell line. changes in the cellu ... | 2010 | 21110324 |
| respiratory viruses in children admitted to hospital intensive care units: evaluating the clart® pneumovir dna array. | viruses play a significant part in children's respiratory infections, sometimes leading to hospitalization in cases of severe respiratory distress. the aim of this study was to investigate respiratory infections in children treated in a hospital intensive care unit (icu). assays were performed using the clart® pneumovir dna array assay (genomica, coslada, madrid, spain), which makes it possible to detect 11 genus of respiratory viruses simultaneously. during the winter of 2008-2009, 73 respirato ... | 2011 | 21108353 |
| nucleoprotein-rna orientation in the measles virus nucleocapsid by three-dimensional electron microscopy. | recombinant measles virus nucleoprotein-rna (n-rna) helices were analyzed by negative-stain electron microscopy. three-dimensional reconstructions of trypsin-digested and intact nucleocapsids coupled to the docking of the atomic structure of the respiratory syncytial virus (rsv) n-rna subunit into the electron microscopy density map support a model that places the rna at the exterior of the helix and the disordered c-terminal domain toward the helix interior, and they suggest the position of the ... | 2010 | 21106738 |
| respiratory syncytial virus prevention and therapy: past, present, and future. | respiratory syncytial virus (rsv) is the most common respiratory pathogen in infants and young children worldwide. more than 50 years after its discovery, and despite relentless attempts to identify pharmacological therapies to improve the clinical course and outcomes of this disease, the most effective therapy remains supportive care. although the quest for a safe and effective vaccine remains unsuccessful, pediatricians practicing during the past decade have been able to protect at least the m ... | 2010 | 21105011 |
| respiratory virus infection and risk of invasive meningococcal disease in central ontario, canada. | in temperate climates, invasive meningococcal disease (imd) incidence tends to coincide with or closely follow peak incidence of influenza virus infection; at a seasonal level, increased influenza activity frequently correlates with increased seasonal risk of imd. | 2010 | 21103353 |
| right ventricular function in children with severe respiratory syncytial virus (rsv) bronchiolitis. | previous studies have demonstrated the development of myocardial damage and hepatitis in children with severe respiratory syncytial virus (rsv) infection. the aim of this study was to assess right ventricular function in children with severe rsv disease and to investigate an association with disease severity, myocardial damage, and hepatitis. | 2010 | 21102401 |
| genotyping and phylogenetic analysis of the major genes in respiratory syncytial virus isolated from infants with bronchiolitis. | we performed the genotyping and phylogenetic analysis of respiratory syncytial virus (rsv) isolated from 17 infants with bronchiolitis in kanagawa prefecture, japan in 2005 and 2006. the major genes in these samples (attachment [g] glycoprotein gene, fusion [f] protein gene, and nucleoprotein [n] gene) were sequenced and analyzed genetically. phylogenetic analysis of these genes revealed that 7 and 10 strains could be classified into subgroups a and b, respectively. phylogenetic analysis of the ... | 2010 | 21099088 |
| risk factors in children hospitalized with rsv bronchiolitis versus non-rsv bronchiolitis. | the trends in hospitalization rates and risk factors for severe bronchiolitis have not been recently described, especially after the routine implementation of prophylaxis for respiratory syncytial virus (rsv) infections. | 2010 | 21098154 |
| severe respiratory syncytial virus infection complicating treatment for infantile hemangioma. | 2010 | 21093672 | |
| reduced innate immune response, apoptosis, and virus release in cells cured of respiratory syncytial virus persistent infection. | it has been reported that cell clones isolated at different passages from a culture of hep-2 cells infected persistently with human respiratory syncytial virus (hrsv) were cured of the virus. further studies on one of these clones (31c1) are reported here, showing that 31c1 cells can still be infected by hrsv but release low amounts of virus to the culture supernatant, develop smaller and less numerous syncytia than the original hep-2 cells, and display only a weak innate immune response to the ... | 2010 | 21093006 |
| viruses and bacteria in acute asthma exacerbations--a ga² len-dare systematic review. | a major part of the burden of asthma is caused by acute exacerbations. exacerbations have been strongly and consistently associated with respiratory infections. respiratory viruses and bacteria are therefore possible treatment targets. to have a reasonable estimate of the burden of disease induced by such infectious agents on asthmatic patients, it is necessary to understand their nature and be able to identify them in clinical samples by employing accurate and sensitive methodologies. this syst ... | 2010 | 21087215 |
| changing costs and the impact on rsv prophylaxis. | acquisition costs of palivizumab have increased in canada since 2007. this analysis aims to re-evaluate the cost effectiveness of palivizumab in canada for premature infants born between 32 and 35 weeks' gestational age using updated 2010 healthcare costs compared to those used in a 2007 decision analytic model. | 2010 | 21087075 |
| efficient lung recruitment of respiratory syncytial virus-specific th1 cells induced by recombinant bacillus calmette-guérin promotes virus clearance and protects from infection. | infection by the respiratory syncytial virus (rsv) can cause extensive inflammation and lung damage in susceptible hosts due to a th2-biased immune response. such a deleterious inflammatory response can be enhanced by immunization with formalin- or uv-inactivated rsv, as well as with vaccinia virus expressing the rsv-g protein. recently, we have shown that vaccination with rbcg-expressing rsv ags can prevent the disease in the mouse. to further understand the immunological mechanisms responsible ... | 2010 | 21084664 |
| treatment of respiratory syncytial virus with palivizumab: a systematic review. | palivizumab has proven efficacy for prophylaxis of respiratory syncytial virus (rsv) in infants with prematurity or congenital heart disease. despite a paucity of data, palivizumab is sometimes used to prevent progression when high-risk patients present with upper respiratory tract infection (urti) due to rsv, or as therapy when any patients present with severe lower respiratory tract infection (lrti) caused by rsv. | 2010 | 21080142 |
| evaluation of therapeutics for rsv: an important step forward. | 2010 | 21079265 | |
| inflammatory responses to acute pneumovirus infection in neonatal mice. | the innate immune responses of neonates differ dramatically from those of adults. here we examine the acute inflammatory responses of neonatal and weanling mice infected with pneumonia virus of mice (pvm), a rodent pathogen (family paramyxoviridae, genus pneumovirus) that replicates the sequelae of severe respiratory syncytial virus infection. | 2010 | 21078159 |
| [two cases of symptomatic west syndrome suffering from severe respiratory syncytial virus-induced bronchiolitis]. | we report two cases of symptomatic west syndrome with severe respiratory syncytial virus (rsv)-induced bronchiolitis: one was a 9-month-old boy who was hospitalized for shock, and the other was a 15-month-old boy in pre-shock condition. both cases needed mechanical ventilation for approximately 2 weeks. seizures from the primary disease worsened in both patients during the infection, and both needed long periods of hospitalization, which resulted in a considerable reduction in their quality of l ... | 2010 | 21077358 |
| performance of a nurse-led paediatric point of care service for respiratory syncytial virus testing in secondary care. | to evaluate respiratory syncytial virus (rsv)-point-of-care-testing (poct) performance among paediatric patients with respiratory symptoms, using the binaxnow(®) rsv assay performed by trained nurses on the paediatric ward, and compare results with those obtained by real-time polymerase chain reaction (pcr). | 2010 | 21073893 |
| viral respiratory tract infections among patients with acute undifferentiated fever in vietnam. | to investigate the proportion of viral respiratory tract infections among acute undifferentiated fevers (aufs) at primary health facilities in southern vietnam during 2001-2005, patients with auf not caused by malaria were enrolled at twelve primary health facilities and a clinic for malaria control program. serum was collected on first presentation (t0) and after 3 weeks (t3) for serology. after exclusion of acute dengue infection, acute and convalescent serum samples from 606 patients were usi ... | 2010 | 21073032 |
| bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies. | nonparametric bayesian techniques have been developed recently to extend the sophistication of factor models, allowing one to infer the number of appropriate factors from the observed data. we consider such techniques for sparse factor analysis, with application to gene-expression data from three virus challenge studies. particular attention is placed on employing the beta process (bp), the indian buffet process (ibp), and related sparseness-promoting techniques to infer a proper number of facto ... | 2010 | 21062443 |
| coronavirus causes lower respiratory tract infections less frequently than rsv in hospitalized norwegian children. | we have described occurrence and clinical manifestations of human coronaviruses (hcov) in hospitalized norwegian children with respiratory tract infection (rti) and compared them with a group of respiratory syncytial virus (rsv)-infected children. methods and population: we used in-house taqman multiplex real-time polymerase chain reaction to test nasopharyngeal samples from 536 rti episodes in 452 children who were admitted during the 2006-2007 winter. twenty-one viruses, including hcov-oc43, h ... | 2011 | 21057374 |