Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| fate of the fellow eye after propionibacterium acnes endophthalmitis. | 1991 | 1882935 | |
| [refractory hiccup after intrapleural injection of corynebacterium parvum]. | 1991 | 1882165 | |
| nosocomial infections of ocular conjunctiva in newborns delivered by cesarian section. | colonization of the ocular conjunctiva in newborns delivered by cesarian section occurs usually within the first day of life. we have studied the flora of the ocular conjunctiva at birth, from 19 newborns delivered by cesarian section, coming from two different maternity hospitals. ocular conjunctiva cultures yielded the main predominant flora in both maternity hospitals considered. the most common genus of this flora are: staphylococcus, corynebacterium and propionibacterium acnes. peptostrepto ... | 1991 | 1870845 |
| controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. | skin absorption of benzoyl peroxide from a topical lotion containing freely dispersed drug was compared with that from the same lotion in which the drug was entrapped in a controlled-release styrene-divinylbenzene polymer system. in an in vitro diffusion system, statistically significant (p = 0.01) differences were found in the content of benzoyl peroxide in excised human skin and in percutaneous absorption. in vivo, significantly (p = 0.002) less benzoyl peroxide was absorbed through rhesus mon ... | 1991 | 1869643 |
| torulopsis candida (candida famata) endophthalmitis simulating propionibacterium acnes syndrome. | four months after undergoing extracapsular cataract extraction with implantation of a posterior chamber intraocular lens, a 74-year-old woman developed granulomatous anterior uveitis. although she initially responded well to corticosteroid therapy, she experienced multiple recurrences on discontinuation of this therapy. slit-lamp examination showed the ocular inflammation to be associated with white cortical material within the lens capsular sac. she underwent removal of the implant as well as t ... | 1991 | 1841584 |
| [immunomodulating properties of acnevac vaccine]. | the influence of acnevac vaccine on immune responses of cba mice was tested. acnevac, the vaccine used in a treatment of patient with acne vulgaris, was produced by a cracow sera and vaccines manufacturer from cultures of propionibacteria-strains. it was shown that acnevac has strong immunomodulatory properties. it strongly stimulates humoral responses, has moderate effect on cell-mediated immune responses and it also activates peritoneal macrophages to release tnf-alpha. | 1991 | 1840429 |
| an open study of teicoplanin in the treatment of gram-positive infections. | teicoplanin, a new glycopeptide antibiotic similar to vancomycin, was evaluated in treating 36 hospitalized patients suffering from various gram-positive infections. the 36 patients received teicoplanin once daily as a mean intravenous injection of 550 mg/day (range 200-800 mg/day). previous antimicrobial therapy was used in 28% of patients. the mean duration of therapy was 7.5 days (range 3-38 days). the overall clinical success rate was 94%. 24/36 patients (66%) had positive microbiology. elim ... | 1991 | 1839742 |
| clinical and bacteriologic evaluation of opc-7251 in patients with acne: a double-blind group comparison study versus cream base. | twenty-eight patients with acne were assigned to 4 weeks of treatment with opc-7251 (a new fluoroquinolone derivative) 1% cream or the cream base in a double-blind manner to evaluate the antibacterial effect of the drug on resident bacteria in the hair follicles and to evaluate clinical response. propionibacterium acnes was isolated from 21 of the 28 acne patients. when the number of p. acnes was compared before and after treatment, the posttreatment p. acnes count in the opc-7251 1% cream group ... | 1991 | 1838749 |
| pathogenesis and pathogenesis related treatment of acne. | 1991 | 1838558 | |
| effects of subminimal inhibitory concentrations of minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism. | comedonal bacteria, propionibacterium acnes, p. granulosum and coagulase-negative staphylococci (cns) seem to play an important initiating role in the inflammatory process by producing neutrophil chemotactic factors. the attracted neutrophils, after phagocytosis, release inflammatory factors such as reactive oxygen species (ros). we investigated the effects of minocycline at subminimal inhibitory concentrations (sub-mic), i.e. one-tenth mic, on the production of human neutrophil chemotactic fact ... | 1991 | 1838472 |
| seborrheic skin and acne vulgaris as protective factors against the development of basal cell epithelioma. | this study was conducted in order to evaluate a possible protective role of seborrheic complexion and a history of acne on the development of basal cell epithelioma (bce). for this purpose, 77 patients with this tumor were examined and asked to fill out a questionnaire. the questionnaire included demographic data and questions about skin type, eye and hair colors, sun exposure habits and a past history of acne. the nature, number and location of tumors, the texture of skin and acne scars were no ... | 1991 | 1835940 |
| the effects of adjuvants on immune responses in cattle injected with a brucella abortus soluble antigen. | five different adjuvants were examined for potentiation of humoral and cell-mediated immune (cmi) responses in cattle to a brucella abortus soluble antigen (basa). two separate experiments were performed involving a total of 64 steers, divided among six groups (experiment 1) and 9 groups (experiment 2). the adjuvants used were: muramyl dipeptide, freund's incomplete adjuvant, dimethyl-dioctadecyl ammonium bromide (dda), bordetella pertussis and propionibacterium acnes. in each experiment, three ... | 1991 | 1835213 |
| acne: current concepts of pathogenesis and approach to rational treatment. | acne is a skin disorder of the sebaceous follicles that commonly occurs in adolescence and young adulthood. the pathogenesis involves abnormal follicular hyperkeratosis and obstruction of the follicle, stimulation of sebaceous gland secretion by androgens, and proliferation of propionibacterium acnes, which promotes inflammation. treatment regimens should be designed based upon an understanding of the multifactorial basis of pathogenesis. both topical and systemic agents may be employed to norma ... | 1991 | 1835004 |
| effects of subminimal inhibitory concentrations of erythromycin, tetracycline, clindamycin, and minocycline on the neutrophil chemotactic factor production in propionibacterium acnes biotypes 1-5. | biotypes 1-5 propionibacterium acnes (p. acnes) strains were grown in the presence of 1/10 minimal inhibitory concentrations (sub-mic) of erythromycin (em), tetracycline (tc), clindamycin (cldm), or minocycline (mino) and their culture filtrates were assayed for human neutrophil chemotactic activity using boyden chamber methods. the addition of sub-mic of mino to the medium strongly suppressed the neutrophil chemotactic activity of the culture filtrates of p. acnes strains of all biotypes. in co ... | 1991 | 1834712 |
| immunomodulation in an apparently non-immunogenic murine tumor. | madison lung carcinoma (m109), a murine tumor of spontaneous origin, appears to be non-immunogenic, according to 2 commonly employed tests for tumor immunogenicity. however, c.parvum-induced immunopotentiation during the growth of m109 tumor results in post-excision anti-tumor immunity to m109 tumor implants. the c.parvum-potentiated post-excision immunity to m109 is tumor-specific and t-cell-dependent. t cells from mice whose progressive m109 tumors have been excised are capable, on passive tra ... | 1991 | 1833344 |
| acne vulgaris. pathogenesis and treatment. | acne vulgaris is a multifactorial disease involving abnormalities in follicular keratinization, sebum production, proliferation of propionibacterium acnes, and inflammation. treatment is directed toward reversing these underlying pathogenic factors. therapeutic options include topical comedolytics, topical and systemic antibiotics, hormonal manipulations, and oral retinoids. | 1991 | 1831256 |
| correlation between antimicrobial activity and chelating ability of 2-(n,n,n-trialkylammonio)alkyl hydrogen phosphates. | the chelating abilities of phosphobetaines [2-(n,n,n-trialkylammonio)alkyl hydrogen phosphates; 1] for divalent cations (e.g., calcium ion, zinc ion, copper ion, and cadmium ion) were investigated to elucidate the correlation between the antimicrobial activity and the chelating ability. the maximal chelating ability was obtained with the compound having a dimethylene bridge as an intercharge distance between the phosphate and quaternary ammonium group; in contrast, the minimum was obtained with ... | 1991 | 1815056 |
| hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1h-1-benzazepin-3,5-dione hydrochloride (kf-14363) in various experimental liver injuries. | hepatoprotective effects of kf-14363 were investigated in the following experimental models. kf-14363 inhibited the increase in serum glutamate pyruvate transaminase (gpt) dose-dependently, and a significant inhibition was noted at a dose of 30 mg/kg or more. kf-14363 significantly inhibited the d-galactosamine (d-gal)-induced increase in serum transaminase by oral administration at 250 mg/kg x 1 and 250 mg/kg x 2 doses. the d-gal-induced decrease in total protein levels was inhibited at doses o ... | 1991 | 1812294 |
| [counts of selected strict and facultatively anaerobic microorganisms in the crop and appendix of chickens and their adhesion characteristics]. | the counts of strictly anaerobic amylolytic and lactate-utilizing bacteria, streptococci, lactobacilli, escherichia coli and lactoso-negative bacteria were followed in chicks at the age of three to seven weeks. age dependences of the counts in the given groups were investigated. an increase in the counts of amylolytic bacteria was observed in the caecum contents in the seventh week (4.63 +/- 0.322), and on the other hand a decrease in their counts in the caecum wall in the seventh week (3.30 +/- ... | 1991 | 1807031 |
| comparative in vitro activity of cefpodoxime against anaerobes other than bacteroides fragilis. | to assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. for comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were also tested. cefpodoxime was found to be active at concentrations of less than or equal to 0.125 mg/l against prevotella oralis, prevotella buccalis, prevotella bivia, porphyromonas a ... | 1991 | 1800380 |
| latex agglutination test: an adjunct to the laboratory diagnosis of pyogenic bacterial meningitis. | gram stain, culture and latex agglutination test (lat) of cerebrospinal fluid were performed in 50 patients clinically diagnosed as suffering from pyogenic bacterial meningitis. using all the three techniques, an aetiological diagnosis was made in 27 (54%). neisseria meningitidis, streptococcus pneumoniae and h. influenzae were the infecting organisms in 21 cases (44%). there were 12 additional cases in which lat was the only clue to the diagnosis as compared to conventional techniques. propioni ... | 1991 | 1800334 |
| [activation of the resident microbial flora as a possibility for the improvement of humoral antibody potentials]. | the effect of a parenteral application of an adjuvant (propionibacterium acnes) and an adjuvant/antigen combination (staphylococcus aureus cowan i/al(oh)3, pseudomonas aeruginosa/al(oh)3 respectively, was tested with regard to the improvement of antibacterial resistance. parameter was the humoral antibody production (igg) of rabbits against six facultative pathogen bacterial species (st. aureus, sc. faecium, bac. cereus, p. multocida, e. coli, ps. aeruginosa) and against sheep rod blood cell mem ... | 1991 | 1786043 |
| effect of gomisin a in the prevention of acute hepatic failure induction. | nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed propionibacterium acnes followed by a small amount of gram-negative lipopolysaccharide 7 days later. however, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin a extracted and purified from schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity t ... | 1991 | 1775571 |
| posterior lens capsule abscess due to propionibacterium acnes and staphylococcus epidermidis following extracapsular cataract extraction. | a case of posterior lens capsular abscess occurring many months after an extracapsular cataract extraction is presented. this was caused by a mixed infection involving propionibacterium acnes and staphylococcus epidermidis. the significance of staph epidermidis after such a long postoperative period is uncertain, but the case shows features typical of secondary endophthalmitis due to p acnes, including a long delay in onset and a grumbling course not brought under control by medical treatment. i ... | 1991 | 1768656 |
| propionibacterium acnes endophthalmitis. | 1991 | 1768654 | |
| efficacy of cloxacillin prophylaxis in craniotomy: a one year follow-up study. | a previous prospective double-blind placebo-controlled study showed that cloxacillin prophylaxis significantly reduces the rate of infection after craniotomy. the purpose of the present follow-up study was to find out whether the data on routine cloxacillin prophylaxis would confirm the decreased infection rate after craniotomy. during this 1-year study, 8 infections occurred after 201 operations (4.0%) in 175 patients. no prophylaxis was given during 17 operations in 15 patients; 4 infections o ... | 1991 | 1767259 |
| [intrascrotal and seminal vesicular granuloma probably induced by propionibacterium acnes]. | a case of right intrascrotal and seminal vesicular granuloma probably induced by propionibacterium acnes is reported. a 62-year-old man was admitted to our department because of low grade fever and the right intrascrotal and retrovesical masses without tenderness. ultrasonography computed tomography, magnetic resonance imaging and vesiculography suggested a neoplasm. however, leukocytosis and high erythrocyte sedimentation rate (esr) and c-reactive protein level (crp) suggested inflammatory dise ... | 1991 | 1755428 |
| inhibition of immune reactions in vivo by liposome associated transforming growth factor (tgf) type beta 1. | in view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (tgf) beta 1 to down-regulate immune responses in vivo. preliminary experiments suggested that, at the doses used, systemic injection of soluble tgf beta 1 could not affect bacterial-induced spleen enlargement in mice. therefore, we sought to utilize a physiochemical property of this molecule, namely its high pi, to determine possible association between the liga ... | 1991 | 1747960 |
| cutaneous immunopathology of androgenetic alopecia. | male pattern baldness is assumed to result from a combination of normal serum concentrations of androgen and an appropriate genetic background. to study whether inflammation contributes to the development of androgenetic alopecia, direct immunofluorescence and dermatopathologic studies were performed on biopsy specimens from bald scalp of patients, with specimens from uninvolved scalp of these patients or from scalp of volunteers who were not bald serving as controls. granular deposits of immuno ... | 1991 | 1744007 |
| endocarditis after acupuncture and injection--treatment by a natural healer. | 1992 | 1727196 | |
| the in-vitro antimicrobial effects of azelaic acid upon propionibacterium acnes strain p37. | the in-vitro antimicrobial activity of azelaic acid a new topical acne treatment, upon propionibacterium acnes strain p37 was studied. in phosphate buffer at ph 6.0 500 mm azelaic acid had bactericidal activity whilst the addition of nutrients reduced susceptibility. bactericidal activity was greatly enhanced by reducing the ph to 5.6. in a simple defined medium growth was inhibited by 100 microm azelaic acid. the accumulation of 14c azelaic acid was ph and temperature dependent with maximum upt ... | 1991 | 1726169 |
| use of immunomodulators as an aid to clinical management of feline leukemia virus-infected cats. | 1991 | 1724773 | |
| inhibition of nk cell generation by corynebacterium parvum. | treatment of mice with corynebacterium parvum (cp) resulted in a substantial decrease of splenic nk activity associated with a reduced number of lgl. cp also inhibited in vitro augmentation of nk cytotoxicity by ifn or il-2 as well as generation of lak activity. localization experiments by using radiolabelled lgl indicated that the lower number of lgl in the spleen was not attributable to a cp-induced alteration of lgl homing. finally cp was found to affect the ability of bone marrow cells to re ... | 1991 | 1723083 |
| corynebacterium parvum (propionibacterium acnes): an inducer of tumor necrosis factor-alpha in human peripheral blood mononuclear cells and monocytes in vitro. | the present study investigates the potential capacity of the immunostimulant corynebacterium parvum (c.p.) to induce tumor necrosis factor-alpha (tnf-alpha) in human peripheral blood mononuclear cells (pbmc) and blood monocytes (bmo) in vitro. both at the mrna and protein level, stimulation of pbmc and bmo upon c.p. induces tnf-alpha. compared to the hitherto used tnf-alpha inducers in vitro such as sendai virus, phytohemagglutinin or lipopolysaccharide the c.p. stimulus displayed a threefold st ... | 1990 | 1698632 |
| tetracycline and 13-cis-retinoic acid inhibit production and activity of granulocyte activating factor (gaf) from propionibacterium acnes. | the aim of this study was to evaluate different treatment schedules on release or activity of a granulocyte activating factor (gaf) from propionibacterium acnes. incubation of p. acnes in physiological saline (30 min, 37 degrees c) resulted in release of a soluble factor that elicited considerable chemiluminescence response and chemotactic stimulus on human granulocytes. pretreatment of the microorganisms with subinhibitory concentrations of tetracycline or incubation of granulocytes with 13-cis ... | 1990 | 1698375 |
| mechanism of gram variability in select bacteria. | gram stains were performed on strains of actinomyces bovis, actinomyces viscosus, arthrobacter globiformis, bacillus brevis, butyrivibrio fibrisolvens, clostridium tetani, clostridium thermosaccharolyticum, corynebacterium parvum, mycobacterium phlei, and propionibacterium acnes, using a modified gram regimen that allowed the staining process to be observed by electron microscopy (j. a. davies, g. k. anderson, t. j. beveridge, and h. c. clark, j. bacteriol. 156:837-845, 1983). furthermore, since ... | 1990 | 1689718 |
| the appearance of t cells bearing self-reactive t cell receptor in the livers of mice injected with bacteria. | we demonstrated in the present study that with bacterial stimulation, an increased number of alpha/beta t cells proliferated in the liver of mice and that even t cells bearing self-reactive t cell receptor (tcr) (or forbidden t cell clones), as estimated by anti-v beta monoclonal antibodies in conjunction with immunofluorescence tests, appeared in the liver and, to some extent, in the periphery. the majority (greater than 80%) of forbidden clones induced had double-negative cd4-8-phenotype. in a ... | 1991 | 1677392 |
| changes in polyphosphate composition and localization in propionibacterium acnes after near-ultraviolet irradiation. | electron microscopy showed that electron-dense granules accumulated in propionibacterium acnes in larger amounts when the bacteria were grown on a phosphate-rich medium. x-ray microanalysis demonstrated that the granules contained mostly phosphorus and potassium, indicating that the cells contained polyphosphate granules. when cells were grown on a complex bacto-agar medium, the amount and the size of the polyphosphate granules were reduced. polyphosphate was also detected with 31p nuclear magne ... | 1991 | 1655185 |
| near-uv-induced radicals in propionibacterium acnes, studied by electron spin resonance spectrometry at 77 k. | suspensions of propionibacterium acnes were uv irradiated and the induced radicals were measured at 77 k by electron spin resonance (esr) spectrometry. two types of radical were formed during irradiation and stabilized in the frozen suspensions. the relative yield of each radical was studied as a function of irradiation wavelength. the first radical, which was a singlet with a peak-to-peak width of 20 g, was insensitive to the deoxygenation of the samples and to the exchange of solvent water by ... | 1991 | 1650821 |
| activity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin. | mersacidin, a new peptide antibiotic, was four- to eightfold less active (mic for 90% of isolates, 8 micrograms/ml) than vancomycin, teicoplanin, or daptomycin against staphylococcus aureus. coagulase-negative staphylococci were inhibited by 8 micrograms/ml, and the mics of mersacidin for hemolytic streptococci and streptococcus pneumoniae were 4 to 8 micrograms/ml. the mersacidin mics for anaerobic organisms were as follows: clostridium perfringens, 4 micrograms/ml; propionibacterium acnes, 8 m ... | 1991 | 1649577 |
| effects of corticosterone and microgravity on inflammatory cell production of superoxide. | in this investigation we studied the effects of corticosterone and microgravity on propionibacterium acnes-induced inflammatory cells ability to produce superoxide (o2-). we found in vitro and in vivo exposure of murine peritoneal inflammatory cells to corticosterone did not inhibit the o2- response. we also found that in microgravity p. acnes-induced inflammatory cells were capable of producing four times as much o2- as at 1g. therefore, neither corticosterone nor microgravity experienced durin ... | 1991 | 1647434 |
| immunologically mediated fatigue: a murine model. | chronic fatigue syndrome (cfs) is an idiopathic disorder in which the chief symptoms is profound fatigue. to explore the relationship between immune stimulation and fatigue, we developed a murine model for quantifying fatigue: reduction in voluntary running and delayed initiation of grooming after swimming. inoculation of female balb/c mice with corynebacterium parvum antigen or the relatively avirulent me49 strain of toxoplasma gondii induced fatigue: baseline running reduced to less than 50 an ... | 1992 | 1643746 |
| iris nodule and intralenticular abscess associated with propionibacterium acnes endophthalmitis. | 1992 | 1637275 | |
| a zymographic assay for detection of hyaluronidase activity on polyacrylamide gels and its application to enzymatic activity found in bacteria. | a zymographic assay for the determination of hyaluronidase activity in cell-free extracts on native polyacrylamide gels has been developed. in this assay an agarose replica of the polyacrylamide gel which contains hyaluronic acid and bovine serum albumin (bsa) was used. after an incubation at 37 degrees c to allow transfer and development of enzymatic activity, the hyaluronic acid and bsa were precipitated in the agarose gel with 2 m acetic acid. areas of enzymatic activity appeared as clear zon ... | 1992 | 1632506 |
| some characteristics of blood shed into the solcotrans postoperative orthopaedic drainage/reinfusion system. | to assess the suitability of blood shed into the solcotrans orthopaedic autotransfusion system as a source of autologous blood for transfusion. | 1992 | 1630397 |
| protective effects of (2e)-3-[5-(2,3-dimethoxy-6-methyl-1,4- benzoquinoyl)]-2-nonyl-2-propenoic acid on endotoxin-mediated hepatitis in mice. | e3330 [(2e)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid] is a newly synthesized hepatoprotective quinone derivative. we examined the protective effects and possible mechanism of action of e3330 in three different endotoxin (lipopolysaccharide)-induced murine hepatitis models, in which tumor necrosis factor is suggested to play a critical role in the pathogenesis. one of these models was induced by i.v. injection of lipopolysaccharide in combination with d-galactosam ... | 1992 | 1625194 |
| effects of intravesical corynebacterium parvum on recurrences of superficial tumors of the urinary bladder. | we studied 96 patients with superficial tumors of the urinary bladder treated by transurethral resection in order to investigate the value of intravesical corynebacterium parvum (cp) to prevent recurrences. in 52 cases, two vials (2 ml, 4 mg cp) diluted in 60 ml buffer saline were intravesically administered weekly 12 times and then monthly for a period of 2 years. all patients were studied in a 3 year follow-up by cytology, histology and endoscopy. recurrences were observed in 21.1% of cases in ... | 1992 | 1623214 |
| the effect of zinc and erythromycin on the growth of erythromycin-resistant and erythromycin-sensitive isolates of propionibacterium acnes: an in-vitro study. | the effect of zinc and erythromycin on cultures inoculated with mixtures of different ratios of erythromycin sensitive (es) and resistant (er) propionibacterium acnes cells was studied in vitro. propionibacterium acnes es outgrew p. acnes er in the absence of erythromycin and zinc. at low levels of erythromycin es outgrew er, whilst the addition of 600 pg/ml zinc further reduced the growth of er compared to es. growth of er and es were similar at levels of erythromycin near the minimum inhibitor ... | 1992 | 1610692 |
| alternative antimicrobial agents to contemporary treatment of infections caused by corynebacterium parvum (propionibacterium acnes) | 1992 | 1607339 | |
| susceptibility of anaerobic bacteria to tosufloxacin. | the in vitro activity of tosufloxacin against anaerobic cocci, propionibacterium acnes, clostridium perfringens, clostridium difficile, bacteroides fragilis, bacteroides spp. and fusobacteria was determined by the agar dilution method. this activity was compared with that of ciprofloxacin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole and chloramphenicol. tosufloxacin, imipenem, clindamycin, metronidazole and chloramphenicol were the most active agents tested. tosufloxacin has an ... | 1992 | 1597207 |
| high serum il-6 level reflects susceptible status of the host to endotoxin and il-1/tumor necrosis factor. | patients with high level of serum endotoxin did not necessarily develop into lethal shock, whereas some patients died of septic shock even when their serum endotoxin levels were low. these results indicate that limiting factor which determines the host to be endotoxin shock principally depends on the host susceptibility to endotoxin instead of serum endotoxin level. to understand this susceptible status of the host to endotoxin, we used propionibacterium acnes primed mouse endotoxin shock model. ... | 1992 | 1588048 |
| corynebacterium parvum can reverse the depression of macrophage hydrogen peroxide production caused by erythrocyte phagocytosis. | our previous studies have shown that the phagocytosis of igg-coated erythrocytes (eigg) in vivo increases the mortality rate with bacterial infection, and eigg phagocytosis in vitro depresses phorbol myristate acetate (pma)-triggered h2o2 production. the present study was undertaken to determine if the depression of h2o2 production caused by eigg phagocytosis could be reversed by exposing macrophages to priming agents. macrophages exposed to 100 micrograms/ml of c. parvum, it's pyridine-soluble ... | 1992 | 1587558 |
| propionibacterium acnes endophthalmitis after intracapsular cataract extraction. | the authors report a case of propionibacterium acnes endophthalmitis after intracapsular cataract extraction with implantation of an anterior chamber intraocular lens. the patient's chronic inflammation persisted for 5 years after cataract surgery despite treatment with pars plana vitrectomy, intraocular lens removal, topical and oral steroids, and topical fortified antibiotics. fluctuations in the inflammation were paralleled by changes in the size and appearance of a white plaque on the poster ... | 1992 | 1584564 |
| generation of cytotoxic immune responses against a rat glioma by in vivo priming and secondary in vitro stimulation with tumor cells. | cytotoxic t lymphocyte (ctl) responses to most antigens are generated by in vivo priming and secondary stimulation with antigen in vitro. the present studies were designed to determine whether that strategy could be used to stimulate development of ctl against brain tumors. rats were primed with one of two tumors, rt2, an astrocytoma, or 9l, a gliosarcoma, and corynebacterium parvum. spleen cells from primed rats were stimulated with tumor cells and interleukin-2 in vitro to generate ctl. ctl ge ... | 1992 | 1584347 |
| influence of corynebacterium parvum-per on disease progression in the nzb/w model of systemic lupus erythematosus. | murine models of systemic lupus erythematosus (sle) exhibit some, but not all, of the characteristics of human disease. disease progression in the animal models is regulated by autoantibodies, genetics and inflammatory processes. in the present study, the influence of the pyridine extract residue of corynebacterium parvum type i (cp-per) on disease progression in the nzb/w model of sle was investigated. cp-per is known to activate the reticuloendothelial (re) system of mice and can alter a numbe ... | 1992 | 1582732 |
| induction of murine lymphokine-activated killer-like cells by corynebacterium parvum (c. parvum) in vitro: lysis of tumor cells and macrophages by c. parvum-induced killer cells. | in vitro culture of murine spleen cells with corynebacterium parvum (c. parvum) was found to induce lymphokine-activated killer (lak)-like cells capable of killing both natural killer (nk)-sensitive and nk-resistant tumor cells as well as syngeneic macrophages (m phi). the induction of lak-like activity by c. parvum was significantly inhibited by anti-interleukin-2 (il-2) or anti-interferon (ifn) alpha, beta antibody (ab), and it was further inhibited by the combination of two abs, suggesting th ... | 1992 | 1580562 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 23-1992. a 55-year-old man with recurrent pericardial and pleural effusions after aortic-valve replacement. | 1992 | 1579139 | |
| propionibacterium acnes keratitis. | 1992 | 1575243 | |
| [release of interleukin-6 by alveolar macrophages in patients with sarcoidosis]. | the supernatants from cultures of alveolar macrophages from 12 patients with sarcoidosis and 7 control subjects were assayed for interleukin-6 (il-6) using an elisa system. il-6 was detectable without a stimulant in supernatants from all subjects with sarcoidosis and controls. however, the supernatants from 4 of 12 untreated patients with sarcoidosis contained significantly greater amounts of il-6. when macrophages were stimulated by propionibacterium acnes (p. acnes), the mean level of il-6 in ... | 1992 | 1569718 |
| gamma interferon mediates propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. | pretreatment of lipopolysaccharide (lps)-responder c57bl/10scsn mice with killed propionibacterium acnes enhanced tumor necrosis factor alpha (tnf-alpha) production and lethality in response to a subsequent challenge with lps. sensitization to lps increased with time of pretreatment and reached its maximum after 7 days. sensitization was paralleled by gamma interferon (ifn-gamma) production that was detectable from day 3 onward. in contrast, a similar p. acnes pretreatment of lps-nonresponder c5 ... | 1992 | 1563791 |
| propionibacterium acnes prosthetic valve endocarditis: a case of severe aortic insufficiency. | propionibacterium acnes rarely causes systemic disease. few cases of p. acnes endocarditis have been reported. this report describes a 63-year-old man who presented with severe congestive heart failure. he had prosthetic valve endocarditis which resulted in severe acute aortic insufficiency. during surgery he was found to have complete disruption of the aorta and left ventricle with a false aneurysm encompassing the circumference of the aortic annulus. cultures of the valve grew p. acnes. thus, ... | 1992 | 1563134 |
| separation of soluble amoebicidal and tumoricidal activity of activated macrophages. | macrophage-conditioned medium (m phi cm) prepared from mouse peritoneal macrophages activated in vivo with bacillus calmette-guérin (bcg) or propionibacterium acnes and triggered with lipopolysaccharide in vitro contained tumoricidal and amoebicidal activity. the murine fibroblast cell line l929 was used as the indicator of tumoricidal activity and naegleria fowleri amoeba was used to detect amoebicidal activity in m phi cm. the protease inhibitor, soybean trypsin inhibitor, decreased tumoricida ... | 1992 | 1560419 |
| propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat. | propionibacterium acnes (corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. in addition to its role as an infectious agent, p. acnes also may possess adjuvant-like or adjuvant-enhancing properties. the presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. we have modified an established ... | 1992 | 1559776 |
| antimicrobial susceptibility of anaerobic bacteria in auckland 1987-90. | the antimicrobial susceptibility of 292 clinical isolates of anaerobic bacteria was determined by a standard agar dilution method. metronidazole was the most active agent with only one bacteroides fragilis, two anaerobic cocci, and propionibacterium acnes being resistant. for b fragilis itself and other members of the b fragilis group: 35/35 (100%) and 43/44 (98%) respectively, were susceptible to amoxycillin-clavulanic acid; 47/47 (100%) and 55/56 (98%) respectively, were susceptible to cefoxit ... | 1992 | 1549266 |
| bacteriologic and endotoxin analysis of salvaged blood used in autologous transfusions during cardiac operations. | autologous blood transfusion is a common method of reducing the need for heterologous blood transfusion during cardiac operations. recently we investigated an outbreak of severe, nonsurgical postoperative bleeding among patients undergoing heart operations and receiving intraoperative transfusion of blood from a cell conservation device (cell saver system, haemonetics corp., braintree, mass.). as a result of this investigation, we conducted a prospective study to determine if bacterial or endoto ... | 1992 | 1545559 |
| antimicrobial activity of sphingosines. | the antimicrobial activity of stratum corneum lipids was examined by screening in vitro various representative phospholipids and sphingolipids. of mixed galacto-cerebrosides; phosphatidic acid; phosphatidic acid-monomethylester-dioleoyl; phosphatidylethanolamine; phosphatidylethanolamine-beta-oleoyl-gamma-palmitoyl; phosphatidylcholine; d-sphingosine; d,l-sphinganine; 4-d-hydroxysphinganine; oleoyl-sphingosine; n,n-dimethylsphingosine; and stearylamine, only the sphingosines and, to a lesser ext ... | 1992 | 1545135 |
| isolation and properties of the capnocytophaga ochracea bacteriocin. | a bacteriocin from a subgingival plaque isolate of capnocytophaga ochracea was purified and characterized. it was isolated from cell extract and had a molecular weight of 100,000. streptococcus sanguis, streptococcus mitis, streptococcus mutans and propionibacterium acnes were susceptible to the bacteriocin. | 1992 | 1528638 |
| enumeration of subgingival species on primary isolation plates using colony lifts. | this study evaluated the feasibility of using a colony lift method and dna probes to enumerate bacterial species cultured on primary isolation plates. fourteen digoxigenin-labeled whole chromosomal dna probes representing 12 subgingival species were validated by hybridization with colony lifts prepared from 249 reference strains of 51 species grown on trypticase soy agar plates supplemented with 5% sheep blood. colonies of reference strains were lifted onto nytran filters from plates and treated ... | 1992 | 1528619 |
| antibacterial activity of crinitol and its potentiation. | an acyclic diterpene alcohol, crinitol [1], was identified in a marine brown alga, sargassum tortile, as the principal antibacterial agent against gram-positive bacteria, among which propionibacterium acnes was most sensitive and, staphylococcus aureus was least. to enhance its activity, crinitol was combined with several antioxidants, which presumably retard oxidative destruction of this molecule which possesses two easily oxidizable allylic alcohol groups. two synthetic antioxidants, bha (buty ... | 1992 | 1522419 |
| murine kupffer cells and hepatic natural killer cells regulate tumor growth in a quantitative model of colorectal liver metastases. | this investigation aimed to develop a biologically relevant murine model of colorectal liver metastases and determine if kupffer cells (kc) and hepatic natural killer cells (hnkc) regulate tumor growth. the model involves the injection of murine colon adenocarcinoma 26 (mca 26) tumor cells into the portal vein of female-specific pathogen-free balb/c mice. metastases developed in all animals, and the growth was limited entirely to the liver. to determine if kc and hnkc control the development of ... | 1992 | 1505122 |
| influence of the ph-value on the growth of staphylococcus epidermidis, staphylococcus aureus and propionibacterium acnes in continuous culture. | a cutaneous isolate of staphylococcus epidermidis, staphylococcus aureus and propionibacterium acnes was grown in continuous culture at varying ph-values ranging from 5.0 to 8.5. in terms of the specific growth rate as well as the bacterial density during the plateau phase there were remarkable differences. in particular, propionibacterium acnes grew much better in the ph 6.0 to 7.0 range than in a more acidic or alkaline milieu. staphylococcus epidermidis resembled staphylococcus aureus showing ... | 1992 | 1503605 |
| enhancement of prostaglandin e2 production by liver macrophages (kupffer cells) after stimulation with biological response modifiers. | pge2 production by liver macrophages (kupffer cells) activated by biological response modifiers was examined. kupffer cells obtained from a normal rat liver possessed cyclooxygenase activity and produced txb2, pgd2, and pge2 from (1-14c)arachidonic acid. the major product was pgd2. when kupffer cells were incubated in the presence of lipo-polysaccharide (lps), ok-432, or heat-killed propionibacterium acnes for 24 h, the amount of arachidonate cyclooxygenase products increased and the major produ ... | 1992 | 1502248 |
| chronic postoperative endophthalmitis caused by propionibacterium acnes. | persistent intraocular inflammation after cataract surgery with intraocular lens implantation is acquiring importance. frequently, chronic uveitis or the "toxic lens syndrome" have to be differentiated from bacterial infection. this report describes five cases with chronic postoperative endophthalmitis where the anaerobic bacterium propionibacterium acnes was found to be the causative organism. adequate anaerobic culture media and proper sampling from the area around the lens haptics are the mos ... | 1992 | 1498574 |
| preliminary development of a live drug-controlled vaccine against bovine babesiosis using the mongolian gerbil, meriones unguiculatus. | this study investigated the practicality and potential of the gerbil, meriones unguiculatus, as a source of live babesia divergens vaccine and also as a model for the use of the vaccine in cattle. a series of experiments with gerbils concerning vaccine infectivity, immunogenicity and safety were carried out. it was concluded that the use of rpmi medium/40% foetal calf serum as a diluent improved vaccine infectivity, but that the parasitaemia of the blood obtained from donor gerbils had little or ... | 1992 | 1496778 |
| study on the mechanism of an experimental immunological intrahepatic cholestasis model. | tuberculin-sensitized guinea pigs were intravenously injected with heat-killed propionibacterium acnes followed by an intravenous injection of purified protein derivatives 7 day later, resulting in the induction of intrahepatic cholestasis. using this experimental model, the following results were obtained: (1) both uptake and release of bile acid were inhibited in the hepatocytes prepared from the cholestasis guinea pigs. (2) the results of the erythritol clearance method indicated that the dec ... | 1992 | 1488254 |
| comparative activity of the topical quinolone opc-7251 against bacteria associated with acne vulgaris. | the antibacterial activity of the topical quinolone opc-7251 against bacteria commonly found in acne vulgaris was tested in vitro by an agar dilution method. the mic50 was 0.25 mg/l for propionibacterium acnes, 0.125 mg/l for propionibacterium granulosum, 0.03 mg/l for staphylococcus aureus and 0.06 mg/l for coagulase-negative staphylococci. compared with seven other antibiotics tested (ciprofloxacin, penicillin, erythromycin, tetracycline, clindamycin, fusidic acid and gentamicin), opc-7251 had ... | 1992 | 1486893 |
| propionibacterium acnes-metabolites inhibit experimental lung metastasis of murine sarcoma l-1 in balb/c-mice. | adhesive interactions between tumor cells and host tissue occur at several stages of metastasis. such interactions might be inhibited by microbial metabolites resembling the binding regions of matrix molecules. certain metabolite sequences including gly, asp, arg, and ser (gaas) proved to be critical for cell interactions, e.g. with fibronectin. in vitro, the rosette formation of murine pulmonary cells and sarcoma l-1 cells decreased significantly in the presence of propionibacterium acnes-metab ... | 1992 | 1486236 |
| importance of direct hepatocytolysis by liver macrophages in experimental fulminant hepatitis. | when lipopolysaccharide was administered to mice that had been injected with heat-killed propionibacterium acnes, most of them died of massive liver necrosis. previously, we demonstrated that a soluble hepatocytotoxic factor released by liver adherent cells fully activated by both p. acnes and lipopolysaccharide was attributable to the late stage of this severe liver injury. in this report, we focused on the hepatocytolysis by these liver adherent cells in a cell-cell interaction manner. shortly ... | 1992 | 1483670 |
| propionibacterium endophthalmitis. | 1992 | 1480388 | |
| sterility of refrigerated injectable collagen syringes after injection of patient. | injectable collagen has been used for more than 15 years to correct soft tissue cosmetic defects. after injection, the collagen remaining in the syringe is often refrigerated for later use in the same patient, despite manufacturer and food and drug administration recommendations to discard the unused collagen. | 1992 | 1479101 |
| 1,25-dihydroxyvitamin d3 inhibits thromboxane release from activated macrophages. | 1,25-dihydroxyvitamin d3 (1,25-(oh)2d3) in concentrations from 0.1 to 10 nm suppressed immunoreactive thromboxane b2 (itxb2) release from propionibacterium acnes (p. acnes)-elicited liver adherent cells stimulated with lipopolysaccharide (lps, 1 microgram/ml). these suppressive effects of 1,25-(oh)2d3 were also observed in oyster glycogen-elicited peritoneal macrophages. on the contrary, it did not inhibit itxb2 release from both resident kupffer cells and peritoneal macrophages stimulated with ... | 1992 | 1475528 |
| the incidence of bacteraemia following laryngeal mask insertion. | the incidence of bacteraemia following insertion of the laryngeal mask airway (lma) was investigated in one hundred fit patients. four cultures were positive: three represented contamination with skin flora; the other was a microaerophilic streptococcus grown from an anaerobic culture bottle. although this organism can be pathogenic, it may also represent contamination. our findings suggest that significant bacteraemia on insertion of the lma is uncommon and is probably no more than with oral in ... | 1992 | 1463178 |
| prevention of 5-fluorouracil-induced infection with indigenous escherichia coli in tumor-bearing mice by nonspecific immunostimulation. | we have previously reported that the lethal toxicity of 5-fluorouracil (5-fu) in specific-pathogen-free mice is due to an indigenous infection with escherichia coli (k. nomoto, t. yokokura, y. yoshikai, et al. can. j. microbiol. 37:244-247, 1991). in the present study, we demonstrate that nonspecific immunostimulation augments host resistance against the lethal toxicity of 5-fu in tumor-bearing mice. intravenous administration of a preparation of heat-killed lactobacillus casei (lc 9018), a nons ... | 1992 | 1458370 |
| antibacterial activity of totarol and its potentiation. | antimicrobial activity of six diterpenoids isolated from the bark of podocarpus nagi (podocarpaceae) has been tested against twelve selected microorganisms. totarol [1], the most abundant compound among the six, exhibited potent bactericidal activity only against gram-positive bacteria, among which propionibacterium acnes was the most sensitive bacterium. totarol also showed strong activity against four other gram-positive bacteria tested: streptococcus mutans, bacillus subtilis, brevibacterium ... | 1992 | 1453180 |
| the arginine-dependent cytolytic mechanism plays a role in destruction of naegleria fowleri amoebae by activated macrophages. | mouse peritoneal macrophages activated by different immunomodulators (mycobacterium bovis bacillus calmette-guérin or propionibacterium acnes) destroy naegleria fowleri amoebae by a contact-dependent process and by soluble cytolytic molecules secreted by macrophages in response to lipopolysaccharide. the goal of this study was to determine whether the arginine-dependent cytolytic mechanism which results in the production of nitric oxide from arginine by activated macrophages destroys the amoebae ... | 1992 | 1452346 |
| beneficial effects of sk&f 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. | sk&f 105809 is a structurally novel dual inhibitor of lipoxygenase and cyclooxygenase-mediated arachidonic acid (aa) metabolism, which has demonstrated antiinflammatory activity in rodent models of inflammation. in addition, the active metabolite of this compound, sk&f 105561, has been shown in vitro to inhibit the production of the inflammatory cytokine interleukin-1 (il-1) in human monocytes stimulated with lipopolysaccharide (lps). we report here that in vitro sk&f 105561 also blocks the prod ... | 1992 | 1446388 |
| [propionibacterium acnes in the etiology of endocarditis]. | propionibacterium acnes is the gram positive anaerobic bacteria belongs to the normal skin and oral microbial flora. the participation of this microorganism in the infective endocarditis is still controversial. the aim of the study was to perform the diagnostic and therapeutic difficulties in 5 patients with infective endocarditis caused by propionibacterium acnes. in 3 out of 5 patients the infective endocarditis developed after prosthesis valve replacement, in 2 others on the native valves. th ... | 1992 | 1437777 |
| inhibitory effect of (4r)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (sa3443), a novel cyclic disulfide, on the production of tnf-like factor from propionibacterium acnes-primed rat liver macrophages/kupffer cells. | the effect of (4r)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (sa3443), a novel cyclic disulfide, on tumor necrosis factor (tnf)-like factor production from propionibacterium acnes (p. acnes)-primed rat liver macrophages/kupffer cells was investigated. a remarkable increase in tnf-like activity was detected in the culture supernatants of the liver macrophages/kupffer cells from p. acnes-treated rats. at concentrations of 1 x 10(-6) to 1 x 10(-4) m, sa3443 significantly inh ... | 1992 | 1434146 |
| comparisons of the bacterial flora in genital regions at non-pregnancy. | in the development of infectious diseases at non-pregnancy and at pregnancy, correlations between bacterial flora in the vagina and portio vaginalis and the ascending infections of those bacteria have recently been discussed. to clarify the cause of those infectious diseases, we studied the localization of microorganisms in genital regions. patients undergone abdominal total hysterectomy (n = 172) were employed as subjects, and microorganisms isolated from 4 genital regions were studied. in addi ... | 1992 | 1433896 |
| in vitro activity of l-627 against anaerobic bacteria. | the in vitro activity of l-627 against 370 anaerobic bacterial strains including anaerobic cocci, propionibacterium acnes, clostridium perfringens, clostridium difficile, bacteroides fragilis, other bacteroides spp. and fusobacteria was determined by the agar dilution method. this activity was compared with that of piperacillin, cefoxitin, imipenem, meropenem, clindamycin, metronidazole and chloramphenicol. l-627, imipenem, meropenem, clindamycin, metronidazole and chloramphenicol were the most ... | 1992 | 1425740 |
| systemic il-1 and adjuvant treatment of an experimental tumor. i. immune status following tumor rechallenge. | local adjuvant therapy of weakly immunogenic tumors protects against primary tumor challenge. however, this form of therapy does not produce long-lasting immunity to the tumor. in this study, local adjuvant therapy combined with systemic il-1 administration produced not only primary tumor protection, but also long lasting immunity to the tumor. il-1 and adjuvant protected animals resisted rechallenge with tumor as much as 180 days after initial tumor administration. resistance to tumor rechallen ... | 1992 | 1419470 |
| [tibial hyperostosis and propionibacterium acnes]. | in a 39-year-old patient with tibial productive osteitis, propionibacterium acnes was identified in a surgical specimen of the bone lesion. similar cases have been reported by others. the possibility that p. acnes may play in a pathogenic role in the sapho syndrome by causing inflammatory or infectious changes is discussed. | 1992 | 1411197 |
| [hair preparation caused fever and clouding of consciousness]. | 1992 | 1405847 | |
| a case of propionibacterium acnes spinal osteomyelitis. | 1992 | 1396737 | |
| propionibacterium acnes causing an aortic root abscess. | a case of endocarditis caused by propionibacterium acnes associated with an aortic root abscess is presented. this supports the current opinion that aortic root abscesses are not necessarily associated with microorganisms of high virulence. | 1992 | 1389743 |
| inhibition of neutrophil chemotactic factor production in comedonal bacteria by subminimal inhibitory concentrations of erythromycin. | the effect of 1/10 minimal inhibitory concentrations (sub-mic) of erythromycin (em) on human neutrophil chemotactic factor production in comedonal bacteria, propionibacterium acnes strains, propionibacterium granulosum strains and coagulase-negative staphylococcus (cns) strains was assayed using the boyden chamber method. sub-mic of em significantly suppressed neutrophil chemotactic factor production in all strains of p. acnes, p. granulosum and cns. our results suggest that sub-mic of em may ha ... | 1992 | 1386264 |
| polyclonal antibody against an inducible form of nitric oxide synthase purified from the liver of rats treated with propionibacterium acnes and lipopolysaccharide. | a polyclonal antibody was raised in the rabbit against an inducible form of nitric oxide (no) synthase (ec 1.14.23) purified from the liver of rats with acute liver necrosis induced by i.v. administration of propionibacterium acnes and lipopolysaccharide. the antibody immunoprecipitated no synthase activities in the soluble extract of the liver from treated rats. western blot analysis showed that the cytosols of the liver, lung and spleen from the treated rats but not from non-treated rats, and ... | 1992 | 1384469 |
| induction of ca2+/calmodulin-dependent no synthase in various organs of rats by propionibacterium acnes and lipopolysaccharide treatment. | ca2+/calmodulin-dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of propionibacterium acnes and e. coli lipopolysaccharide to rats. examination of the specific induction of ca2+/calmodulin-dependent no synthase showed that the enzyme was induced in the lung, spleen and colon as well as the liver. northern blot analysis revealed that the induction occurred at the transcriptional level. | 1992 | 1379549 |
| study of modulatory effects of olimunostim on cellular immunity in healthy humans. | to objectivize potential modulatory effects of polybacterial lysate olimunostim on cellular immunity, the t-lymphocyte subpopulations and lymphocyte reactivity to mitogens were followed up in 10 healthy volunteers subjected to olimunostim application and parallelly in 6 healthy individuals receiving placebo. the preparation, which was applied perorally in seven consecutive daily doses, had no effects on t-lymphocytes and their subpopulations and exerted only a limited influence on lymphocyte rea ... | 1992 | 1364968 |
| lymphocyte proliferation and t-lymphocyte subsets during experimental immunomodulation of balb/c mice by olimunostim. | to objectivize possible immunomodulatory effects of polybacterial lysate olimunostim (p. acnes, k. pneumoniae, s. aureus), splenic lymphocyte proliferation and t-lymphocyte subsets were followed-up in balb/c mice administered perorally the lysate or saline (controls). the enhanced spontaneous lymphocyte proliferation observed at the beginning of olimunostim application preceded a gradual increase of lymphocyte reactivity to t-mitogens reaching the maximum five days after the administration of th ... | 1992 | 1364967 |