Publications

[abnormal location of ligula intestinalis l. in scardinius erythrophthalmus l. from lake trasimeno].		1986	2944464
in vitro lipid oxidation modifies proteins and functional properties of sarcoplasmic reticulum.	changes in protein and fatty acid compositions of flounder sarcoplasmic reticulum during nadh plus ascorbate-dependent lipid peroxidation in vitro were related to the ability of the sarcoplasmic reticulum to sequester ca+2. progressive accumulation of high-molecular-weight protein components occurred concomitantly with loss of ca+2-sequestering activity. part of this polymerized protein may be the dimer or trimer of ca+2, mg+2-atpase. loss in ca+2, mg+2-atpase protein could account for over 60% ...	2010	2943730
first international symposium and swiss hypertension workshop on atrial natriuretic peptides. 18-19 november 1985, berne, switzerland.		2010	2941529
oligosaccharides obtained by partial hydrolysis of lipopolysaccharide from fusobacterium nucleatum f1.		1986	2937904
correction of iatrogenic floating toe following resection of the base of the proximal phalanx.	for many decades, resecting the base of the proximal phalanx was a popular method of correcting hammertoes. the long-term result of the procedure, however, is a flail, proximally retracted, "floating" toe. correction of this challenging surgical problem can be accomplished with a v-y advancement flap and specific releases.	2010	2937523
[various aspects of the etiology and pathogenesis of endocervicosis].		2010	2935043
thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.	the properties of the sarcoplasmic reticulum membranes isolated from slow-twitch type i soleus and fast-twitch type ii psoas muscles of control and thyroxine treated rabbits were comparatively studied. membrane yield, maximal calcium storing capacity, atp-supported calcium uptake, calcium-dependent atpase activity and calcium-dependent phosphoprotein formation were found to be 3-10 fold higher in psoas than in soleus preparations. membrane yield, calcium-dependent atpase activity, atp-supported ...	1985	2934902
[biological functions and time--the loose coupling mechanism of molecular machines].		2010	2934765
normal immune response to hepatitis b vaccine in patients with down's syndrome. a basis for immunization guidelines.	institutionalized patients with down's syndrome (ds) are uniquely predisposed to develop chronic hepatitis b infection following exposure. therefore vaccination is particularly warranted, but there have been concerns that these individuals may react suboptimally. we examined the immune responses of 62 institutionalized patients with ds to 20 and 40 micrograms of hepatitis b vaccine inactivated (heptavax-b) over one year. the subjects were matched by weight, age, and sex. seroconversion rates and ...	2010	2933533
[occupational dermatomycoses of zoophilic origin in bulgaria].	the relative proportion of zoophilic dermatomycoses is increased in comparison with tinea capitis et pedum. the most frequent zoophilic species now is not only t. mentagrophytes, but t. verrucosum as well. occupational mycoses caused by t. mentagrophytes and t. quinckeanum in vivaria put forward new problems for experimental medicine. the author states his arguments in favour of t. quinckeanum as a separate, specialized species with reduced morphology, forming scutula. t. verrucosum is phylogene ...	1985	2933238
ultraviolet light-induced yellowing of dental restorative resins.		2010	2931511
oral flora of mongrel and beagle dogs with periodontal disease.	the plaque flora was studied in adult mongrel and beagle dogs with periodontal disease. gingival plaque from maxillary premolars was removed and cultured on various growth media. the flora in all dogs was composed of mostly anaerobic gram negative rods. bacteroides asaccharolyticus was found in the highest proportion of plaque samples from mongrel dogs, and decomposed hydrogen peroxide suggesting catalase activity. fusobacterium nucleatum was found in higher proportion in the plaque of beagle do ...	1989	2927018
habituation of optically evoked blink reflex in mentally retarded adults.	this study was done to record the difference in habituation patterns of optically evoked blink reflexes in mentally retarded and normal adults. sets of photic stimuli with fixed interstimulus duration were utilized in normal volunteers and mentally retarded adults. the interstimulus duration decreased with each sequential set. the blink responses were recorded on fibreoptic recording paper. these electrophysiological methods show objectively that the blink responses to light which habituate in n ...	2010	2926795
extrarenal potassium adaptation: the role of aldosterone.	1. prior adaptation to a high potassium (hk) diet reduces the increment in plasma potassium after nephrectomy and acute potassium loading. previous work has suggested that this 'extrarenal potassium adaptation' is due to direct stimulation of cellular potassium uptake by chronic hyperaldosteronism. 2. in contrast, we have shown that when dietary potassium is withdrawn from hk rats, large urinary potassium losses persist, resulting in 'paradoxical potassium depletion'. this potassium depletion fa ...	1989	2924513
race, parental history of hypertension, and patterns of cardiovascular reactivity in women.	this study examined the interaction of race and parental history of hypertension on patterns of cardiovascular responses among women. two stressors were used that produce different patterns of cardiovascular reactivity: mental arithmetic, primarily a beta-adrenergic stimulus, and the cold face stimulus, which evokes alpha-adrenergic (i.e. vascular) activity. systolic and diastolic blood pressure, heart rate, forearm blood flow, and forearm vascular resistance were assessed before, during, and af ...	2010	2922455
monitoring uterine activity at home.		2010	2916595
[clinical trials in norway].		2010	2916210
isolation of a corncob (coaggregation) receptor polypeptide from fusobacterium nucleatum.	corncobs, which are distinct morphological units formed by the ordered coaggregation of a filamentous microorganism and streptococci, can be made in vitro by using oral strains of fusobacterium nucleatum and streptococcus sanguis. previous studies have shown that strains of f. nucleatum contain one of at least two different types of corncob receptor. the objective of this study was to isolate the receptor from f. nucleatum atcc 10953 as the first step in the elucidation of the molecular basis of ...	1989	2912893
the pre-s2 region of hepatitis b virus: more questions than answers.		1989	2912831
effect of growth state, tumor promoters, and transformation upon intercellular communication between c3h/10t1/2 murine fibroblasts.	diminished intercellular communication has been associated with heightened sensitivity of cultured cells to morphological transformation and enhancement of transformation by tumor promoters. microinjection of lucifer yellow dye was employed to evaluate intercellular communication between transformable c3h/10t1/2 murine fibroblasts under a variety of culture conditions. intercellular communication assayed by dye transfer from injected cells to surrounding cells in contact occurred in logarithmica ...	2010	2910519
comparison of the efficacy of four antihistamines in chronic urticaria.		2010	2907911
thalidomide for graft-versus-host disease.		2009	2903342
localization of the mdx mutation within the mouse dystrophin gene.	we have mapped human and mouse x chromosome-specific genomic and cdna probes through an interspecies mus musculus/spretus pedigree which contains the mdx mutation. the positions of these markers relative to one another and to the mdx mutation were delineated. using probes corresponding to segments of the human duchenne muscular dystrophy (dmd) gene transcript, the position of a cross-hybridizing mouse equivalent gene (mdmd) was located. in more than 200 animals mapped, three were identified whic ...	1988	2903046
uses of calcium channel blocking agents and beta blocking agents in the control of supraventricular arrhythmias.		2010	2902640
phno [(+)-4-propyl-9-hydroxynaphthoxazine]: a new and effective anti-parkinson's disease agent.	phno [(+)-4-propyl-9-hydroxynaphthoxazine] is a chemically novel and highly potent dopamine (d2) receptor agonist without d1 activity. it had significant antiparkinsonism effects when used as open-label monotherapy in ten patients who were hoehn and yahr stage 2 or 3. the standard formulation of phno produced a 3- to 4-hour therapeutic effect in most patients; the response to the time-release formulation lasted up to 10 hours. side effects were similar to those of other dopamine agonists but dys ...	2010	2901697
changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids.	in vitro intracellular recording techniques were used on an excitatory neuromuscular junction of a walking-limb stretcher muscle of the lobster in order to define the synaptic pharmacology of delta-9-tetrahydrocannabinol (thc), 11-hydroxy-thc and cannabidiol. delta-9-tetrahydrocannabinol and 11-hydroxy-thc, in relatively small concentrations, increased the amplitude of the excitatory junctional potential and the mean quantum content of a muscle fiber, whereas larger concentrations produced depre ...	2010	2901683
importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function.		1988	2900297
neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics.	this article described research aimed at testing the hypothesis that tissue remodeling during orthodontic tooth movement is modulated, at least in part, by factors derived from the nervous and vascular (immune) systems. specifically, the neurotransmitters sp and vip and the cytokines il-1 alpha and il-1 beta were localized immunohistochemically in paradental tissues of cat canines that had been treated by the application of an 80 g tipping force for 1 hour to 14 days. increased staining (concent ...	1988	2900159
effects of momorcharins on ovarian response to gonadotropin-induced superovulation in mice.	alpha- and beta-momorcharins, which are abortifacient proteins isolated from momordica charantia seeds, were tested for a possible effect on ovulation and plasma levels of ovarian steroids in mice induced to superovulate by pmsg and hcg. the plant proteins did not affect follicular recruitment and maturation as evidenced by ovarian histology and serum 17 beta-estradiol level. both proteins diminished the number of oocytes ovulated when given on the day prior to or on the day of pmsg treatment, b ...	2010	2898450
comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group a neisseria meningitidis.	during an outbreak of meningococcal meningitis in saudi arabia, oral rifampicin (four doses in two days) was compared with a single intramuscular dose of ceftriaxone for prophylaxis in family contacts of patients with meningococcal disease. pharyngeal samples were taken for culture before and 1 and 2 weeks after administration. both follow-up cultures indicated that ceftriaxone was significantly more effective. at 1 week the eradication rates for ceftriaxone and rifampicin were 97% and 75%; at 2 ...	1988	2897515
[atypical variant of cushing's syndrome].		2010	2897495
the effect of metoclopramide treatment on diabetic cystoparesis.		1988	2897479
involvement of prostaglandins in histamine-induced fluid and electrolyte secretion by rat colon.	histamine increased the transmural potential difference across rat colon in-vivo and induced a net secretion of fluid. both effects were inhibited by indomethacin. histamine increased the potential difference and short-circuit current, and reduced tissue resistance in colonic sheets in-vitro. this response was reduced in the absence of chloride in the bathing medium or in the presence of serosal frusemide, suggesting that histamine stimulated electrogenic chloride secretion by the colon. the ris ...	1988	2897440
mechanism of proline-specific proteinases: (i) substrate specificity of dipeptidyl peptidase iv from pig kidney and proline-specific endopeptidase from flavobacterium meningosepticum.	the substrate specificity of dipeptidyl peptidase iv (dipeptidyl peptide hydrolase, ec 3.4.14.5) from pig kidney and proline-specific endopeptidase from flavobacterium meningosepticum, was investigated with a series of n-terminal unprotected (dipeptidyl peptidases iv) and succinylated dipeptidyl-p-nitroanilides (proline-specific endopeptidase). both enzymes are specific for the s configuration of the amino-acid residue in p1 and p2 position if the penultimate residue is proline. in the case of a ...	1988	2896517
[screening for tetracyclic benzodiazepines using emit-st (benzodiazepines) and tdx].	the article reports threshold ranges and detection limits for the screening of tetracyclic benzodiazepines (adinazolam, alprazolam, brotizolam, estazolam, loprazolam, midazolam, triazolam and many metabolites) using the emit-st and tdx system (fpia). in most cases, the cross reactivities of the two systems are comparable, but there are also remarkable differences. detection limits are mainly in the range between 0.2 and 0.5 mg/l but, in some cases, the limits are also considerably higher. the wi ...	2010	2893500
minimal dose (1.25 micrograms) hepatitis b vaccine for infants and newborn babies, 4 years later.		2010	2891963
desensitization of beta-adrenoceptors following repeated injections of 2-substituted 4-phenylquinolines.	the chronic effects of five 2-substituted 4-phenylquinoline derivatives on the sensitivity of the noradrenergic cyclic amp-generating system in the rat brain cortex have been determined, and compared with those of the typical and atypical antidepressants imipramine and trazodone, respectively. acute treatment (single i.p. dose of 20 mg kg-1) and sub-chronic treatment (20 mg kg-1 daily for 10 days) induced no significant desensitization of the beta-adrenoceptors. however, chronic treatment (20 mg ...	1987	2890745
cholinergic function and alpha-bungarotoxin binding in pc12 cells.	the cell line pc12, derived from an adrenal chromaffin cell tumor, expresses both ganglionic (c6) acetylcholine receptors (nachr) and an alpha-bungarotoxin (bgt) binding protein of unknown function. we measured nicotinic na+ fluxes of 180-260 nmol/mg protein x min and 0.35-0.8 pmol [125i]bgt binding sites/mg protein; 45-65% of the [125i]bgt binding was to intracellular sites. we blocked ganglionic na+ fluxes with reversible and irreversible inhibitors and tested whether a residual bgt-sensitive ...	2010	2890091
action of anticytoskeletal compounds on in vitro cytopathic effect, phagocytosis, and adhesiveness of trichomonas vaginalis.	the cytopathic effects of trichomonas vaginalis treated with inhibitory concentrations of anticytoskeletal compounds (mebendazole, griseofulvin, colchicine, taxol, and cytochalasin b) were studied in mouse clid fibroblast cultures. the evaluation, at different times, of cell numbers and morphological alterations showed that cytopathic effect was considerably reduced when protozoa were pretreated with mebendazole and griseofulvin, whereas colchicine, taxol, and cytochalasin b had less effect. fur ...	1987	2888725
serum levels of bilirubin and biliverdin in the sea lamprey, petromyzon marinus l., before and after their biliary atresia.	1. the sera of ammocoetes, juvenile adults, and upstream migrants of the sea lamprey, petromyzon marinus l., were analyzed for the presence of the bile pigments, biliverdin and bilirubin. 2. bile pigment was not detected in the sera of ammocoetes. 3. after biliary atresia (degeneration of bile ducts at metamorphosis), bilirubin and biliverdin were detected in the sera of both juvenile adults and upstream migrants. 4. these data suggest that lampreys have some bile stasis following biliary atresi ...	2010	2887360
partial characterization of a peptidoglycan-protein complex from fusobacterium nucleatum fev1.	a protein in the cell wall of fusobacterium nucleatum fev1 remained associated with the peptidoglycan during extraction with various detergents and organic solvents. on digestion of this peptidoglycan-protein complex (ppc) with murein hydrolases, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) showed polypeptide bands with apparent molecular weights (mws) in the range of 3000 to 40,000. after reaction with maleic anhydride the electrophoretic mobilities of these polypeptide ...	1987	2887084
efficacy of recombinant dna plasmodium falciparum sporozoite vaccine?		1987	2885674
aids definition for africa.	the positive predictive values for hiv seropositivity are compared using who and us centers for disease control (cdc) clinical case definitions of acquired immunodeficiency syndrome (aids), for cases in rwanda, africa. it is postulated that the article by colebunders and co-workers should encourage clinicians and epidemiologists working in africa to adopt the world health organization's provisional clinical case definition for aids. although the predictive value for hiv seropositivity calculat ...	1987	2885595
eicosapentaenoic and dihomo-gamma-linolenic acids.		2010	2885501
alopecia after immunoglobulin infusion.		2010	2884527
ovarian failure after high-dose melphalan in adolescents.		2010	2884506
[prospects of improving microbial larvicides and methods of control of blood sucking insects and disease vectors].		1987	2883565
european collaborative trial of multifactorial prevention of coronary heart disease.		2009	2882103
polyarteritis nodosa and familial mediterranean fever.	a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ...	2009	2881591
polyarteritis nodosa and familial mediterranean fever.	a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ...	2009	2881591
stimulant-like effects of magnesium on aggression in mice.	the effects of magnesium excesses resulting from daily injections of magnesium chloride (mgcl2) were examined on offensive behavior in a resident-intruder situation. male mice tested 5 min post-injection of 15 mg/kg or 30 mg/kg exhibited a significantly greater number of attacks and threats than saline controls; while in mice injected with 125 mg/kg threat and attack behaviors were decreased. no tolerance developed to this decrease which persisted throughout the 15 day injection period. toleranc ...	2010	2880351
the challenge of malaria vaccine: trials and tribulations.		1987	2880172
sulfasalazine in rheumatoid arthritis. a double-blind, placebo-controlled trial.	sulfasalazine (ssz), 3 gm daily, was compared with placebo for treatment of rheumatoid arthritis, in a 15-week randomized, parallel, double-blind trial. joint tenderness and swelling, morning stiffness, grip strength, and pain score all showed significantly more improvement with ssz than with placebo. adverse effects, particularly gastrointestinal reactions, led to withdrawal from the study of 28% of the patients who had been receiving ssz, but these effects were all readily reversible and not l ...	2010	2879544
[treatment tactics in fractures of the midfoot].	metatarsal fractures can occur as isolated lesions in combination with injuries of the ipsilateral tarsus, or in chain injuries of the lower extremity, or within a polytrauma. the choice of surgical or conservative therapy depends significantly on localisation and dislocation of the fracture (especially the involvement of the metatarsus i or v), as well as on the extent of the primary or expected soft part damage. from 1974 to 1984, 137 patients with metatarsal fractures were treated as in patie ...	2010	2879425
homocysteic acid, an endogenous agonist of nmda-receptor: release, neuroactivity and localization.		1986	2878563
excitatory amino acids and the blood-brain barrier (bbb).		2010	2878562
[activity of cefotetan against anaerobic bacteria].	we determined the susceptibility to antibiotics of 64 strains of obligate anaerobes. tested bacterial strains were as follows: 28 bacteroides fragilis, 22 fusobacterium nucleatum, 10 clostridium perfringens, and 4 bacteroides bivius. tested antibiotics were cefotetan, cefoxitin and piperacillin. cefotaxime was tested against 20 bacteroides fragilis strains. bacteroides fragilis, which is the most resistant species, was susceptible to cefotetan, cefoxitin and piperacillin, with comparable mics fo ...	1986	2877431
[the relation between peptic ulcer and antral g and d cells].		2009	2874960
[the relation between peptic ulcer and antral g and d cells].		2009	2874960
food incentives to improve clinic attendance.		2010	2873484
effectiveness of omeprazole in seven patients with zollinger-ellison syndrome resistant to histamine h2-receptor antagonists.	the inhibitory effect of omeprazole, a benzimidazole derivative, on gastric acid secretion was investigated in seven patients with zollinger-ellison syndrome resistant to treatment with large doses of histamine h2-receptor antagonists administered alone or in combination with pirenzepine. in two patients with an acute form of the syndrome, rapid control of acid overproduction was achieved with 180-mg intravenous and 120-mg oral daily doses, respectively. the other five patients, who were free of ...	2009	2873001
long-term experience with terazosin for treatment of mild to moderate hypertension.	two hundred twenty-six patients with mild to moderate hypertension were treated with terazosin in an open, multicenter study to determine the drug's long-term efficacy and safety. all patients had previously received terazosin in a short-term study; 66 patients entered from later short-term studies and had experienced a 7 mm hg decrease in supine diastolic blood pressure in response to terazosin. terazosin was administered once or twice daily either alone or in combination with a diuretic and/or ...	2010	2872810
[limitation of phage multiplication by microbes of the genus bordetella].	possible causes limiting the multiplication of bordetella phages or inducing their restriction, such as the influence of lysogenic immunity and the restriction-modification (r-m) system or the incompatibility of the receptor apparatus, have been studied. the limitation of the multiplication of phages by some b. bronchiseptica and b. pertussis strains has been shown to be due to the presence of the r-m system and lysogenic immunity. in five b. bronchiseptica strains and two b. pertussis strains s ...	1985	2868594
rheumatoid arthritis and schizophrenia: are they mutually exclusive?	the relationship between schizophrenia and rheumatoid arthritis has been explored in a number of studies. it has been claimed that the two disorders are mutually exclusive. review of the literature indicates that the two conditions seldom coexist. the underlying mechanisms responsible for the infrequent coexistence of schizophrenia and rheumatoid arthritis are far from clear. however, various hypotheses have been proposed to explain the negative correlation between the two diseases.	2010	2863874
bone marrow under attack.		2010	2863550
[management of degenerative changes in the femoro-patellar joint].		2010	2863426
myoglobin in the heart tissue of fishes lacking hemoglobin.	myoglobin has been identified in the heart tissue of three species of antarctic icefish, chaenocephalus aceratus, pseudochaenichthys georgianus and chaenodraco wilsoni. quantitative analysis shows myoglobin concentrations that are substantially lower than other teleost fish. a simple and accurate method for the direct measurement of myoglobin in tissue is described.	1985	2863077
maternal mortality--a neglected tragedy. where is the m in mch?		2009	2861534
[ultrastructural and immunohistochemical studies on pleomorphic adenoma and clear cell adenoma arising from salivary gland].		2010	2855893
hematometra complicating hormone replacement therapy after radiation for cervical carcinoma.	hematometra developed in a patient receiving sequential estrogen-progestogen hormone replacement therapy following radiation for cervical carcinoma. diagnosis, treatment and therapeutic recommendations are discussed.	2010	2851962
preparation by direct metal exchange and kinetic study of active site metal substituted class i and class ii clostridium histolyticum collagenases.	active site metal substitutions for both gamma- and zeta-collagenases from clostridium histolyticum have been made by direct metal exchange. the incubation of co(ii), cu(ii), ni(ii), cd(ii), and hg(ii) with these native collagenases results in changes in activity that parallel those observed for the reconstitution of the respective apoenzymes with these metal ions. for both collagenases, the exchange reactions with co(ii) and cu(ii) are complete within 1 min. however, the changes in activity obs ...	1988	2849992
antiviral chemoprophylaxis for cytomegalovirus infection.		1988	2849602
[role of alpha-1 and alpha-2-adrenoreceptors in achieving the compensatory response of the hemostasis system to plasmin].		1988	2849566
enzymic capacities of amyloplasts from wheat (triticum aestivum) endosperm.	lysates of protoplasts from the endosperm of developing grains of wheat (triticum aestivum) were fractionated on density gradients of nycodenz to give amyloplasts. enzyme distribution on the gradients suggested that: (i) starch synthase and adp-glucose pyrophosphorylase are confined to the amyloplasts; (ii) pyrophosphate: fructose-6-phosphate 1-phosphotransferase and udp-glucose pyrophosphorylase are confined to the cytosol; (iii) a significant proportion (23-45%) of each glycolytic enzyme, from ...	2010	2849412
ecology of colorado tick fever.		1988	2849373
role of absorptive and secretory processes in hydration of the airway surface.	in the conducting airways, epithelial electrolyte transport processes play an important role in controlling the quantity and the composition of the airway surface solution layer. hydration of the airway surface appears to promote effective mucociliary clearance and to influence the rheology of mucins, and together these factors provide a major mechanism for airway defense. the cellular processes governing absorption and secretion of salt are similar, if not identical, to those that have been des ...	2010	2849352
[a case of hepatocellular carcinoma with intratumoral gas formation detected by plain abdominal x-ray film].		2010	2846919
a method to detect the in vitro modification of serum beta-2-microglobulin in health and disease.	the electrophoretically fast moving form of beta-2-microglobulin (alpha-b2m) was shown by crossed immunoelectrophoresis to be produced in vitro after incubation at room temperature and was not present in freshly drawn sera. a radioisotopic assay was developed to measure this conversion to alpha-b2m in sera from 14 healthy individuals and from 208 patients with benign and malignant disease. the activity was present in all the sera tested and the levels were significantly higher in sera from patie ...	2009	2846212
a method to detect the in vitro modification of serum beta-2-microglobulin in health and disease.	the electrophoretically fast moving form of beta-2-microglobulin (alpha-b2m) was shown by crossed immunoelectrophoresis to be produced in vitro after incubation at room temperature and was not present in freshly drawn sera. a radioisotopic assay was developed to measure this conversion to alpha-b2m in sera from 14 healthy individuals and from 208 patients with benign and malignant disease. the activity was present in all the sera tested and the levels were significantly higher in sera from patie ...	2009	2846212
a substituted thieno[3.4-d]imidazole versus substituted benzimidazoles as h+, k+-atpase inhibitors.	s 3337, 2-(2-ethylaminobenzylsulfinyl)-5,6-dimethoxybenzimidazole, and s 1924, 2-(5-methyl-2-picolylsulfinyl)-1h-thieno[3.4-d]imidazole, are members of new classes of h+, k+-atpase inhibitors. their effects on h+, k+-atpase and 14c-aminopyrine uptake in gastric glands were studied as well as in vivo in pylorus-ligated rats, stomach-lumen-perfused rats and heidenhain pouch dogs. their inhibitory effects were compared with the effect of omeprazole. in pylorus-ligated rats the two compounds showed ...	1988	2841691
construction of an ileal reservoir in patients with a previous straight endorectal ileal pull-through.	a decade has passed since martin and associates presented the first series of endorectal ileal pull-through (pt) procedures with straight ileoanal anastomosis for treatment of ulcerative colitis and polyposis. during the ensuing years, several medical centers have reported their results using the pt. although some children have experienced good results, the majority of adults and children have had severe problems associated with high stool frequency, urgency, and incontinence. between 1977 and 1 ...	2009	2839124
construction of an ileal reservoir in patients with a previous straight endorectal ileal pull-through.	a decade has passed since martin and associates presented the first series of endorectal ileal pull-through (pt) procedures with straight ileoanal anastomosis for treatment of ulcerative colitis and polyposis. during the ensuing years, several medical centers have reported their results using the pt. although some children have experienced good results, the majority of adults and children have had severe problems associated with high stool frequency, urgency, and incontinence. between 1977 and 1 ...	2009	2839124
[hole-shaped defect in the scapula].		2010	2836918
insulin-like growth factor i binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.	insulin-like growth factor-i (igf-i) in human hepatoma cells (hep-g2) has, in addition to its effect on cell growth, short-term metabolic effects acting through its own receptor. we have demonstrated that normal human hepatocytes, compared with hep-g2 cells, have virtually no igf-i binding sites. because the rate of growth is the major difference between the hepatoma and the normal liver, we asked if normal liver might express igf-i binding sites under physiologic growth conditions. indeed, wher ...	1988	2832449
nucleic acid sandwich hybridization in detection of hpv 16 dna: technique and its clinical application.	nucleic acid sandwich hybridization technique was used for detection of hpv 16 specific dna in cervical scrapes. alternating hpv 16-psti fragments were cloned into plasmid pbr322 and phage m13mp10. pbr322-clones were used as 32p-labelled probe reagents and the m13mp10 clones as catching reagents in the assay. the detection limit of the test proved to be 1-5 x 10(5) hpv 16 molecules per test. a weak cross reaction was seen with hpv 31 dna but not with the other types tested, e.g. hpv 6, 11, 18 an ...	2010	2832436
high-performance liquid chromatographic separation and immunological characterization of soluble bovine viral diarrhea virus antigen.	sodium dodecyl sulphate-polyacrylamide gel electrophoresis and western blot analysis of the protein extracts from bovine viral diarrhea virus (bvdv, singer strain) infected primary calf testicle cells (soluble antigen) showed the presence of four virus specific polypeptides of 105, 90, 84 and 67 kilodaltons (kd) the 84-kd being the most abundant. anion-exchange high-performance liquid chromatography (hplc) of soluble antigen separated the virus specific polypeptides in individual peaks while the ...	1988	2832429
evidence for a na+/h+ antiport in stomach smooth muscle cells.	single smooth muscle cells were isolated from circular muscle of the canine gastric corpus by collagenase incubation. cytoplasmic ph (phi) of these cells was measured fluorometrically using the trapped dye 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein. cells were examined for their na+/h+ exchange activity after intracellular acidification. cells acid-loaded by propionate exposure, the nh4+ prepulse technique or suspension in a na+-depleted medium regained almost normal phi upon exposure to a n ...	1988	2831889
immunobiological activities of a porin fraction isolated from fusobacterium nucleatum atcc 10953.	from fusobacterium nucleatum atcc 10953 cell envelope fraction whose inner membranes had been removed by treatment with sodium n-lauroyl sarcosinate, an outer membrane protein (37,000 mr in a native state) was prepared by extraction with lithium dodecyl sulfate. the protein thus obtained showed distinct porin activity, namely, the ability to form hydrophilic diffusion pores by incorporation into the artificial liposome membrane. the porin fraction exhibited strong immunobiological activities in ...	1988	2831155
polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3',5'-adenosine monophosphate.	although theophylline has been used for many years as a principal agent in treatment of reversible obstructive airway disease, the mechanism of drug activity at therapeutic concentrations remains unclear. because inflammatory mediators generated by polymorphonuclear leukocytes (pmn) may be important in the pathogenesis of airway hyperreactivity, the effects of theophylline upon pmn activation were studied. theophylline (9 micrograms/ml, 50 microm) inhibited pmn leukotriene b4 generation by 50%, ...	2010	2827546
the sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin.	we have sequenced a cdna, isolated from a chick embryo fibroblast lambda gt11 library, that encodes all 887 amino acids of alpha-actinin. sequence from 10 different peptides from chick smooth muscle alpha-actinin was found to match that derived from the cdna. the deduced protein sequence can be divided into three distinct domains: (a) the n-terminal 240 amino acid contains a highly conserved region (compared with dictyostelium alpha-actinin) which probably represents the actin-binding domain, (b ...	1987	2826427
subcellular localization of enzymes in streptomyces aureofaciens and its alteration by benzyl thiocyanate. i. phosphatases and atp-glucokinase.	mycelia of a low- and a high-production strain of streptomyces aureofaciens were converted into protoplasts and divided into five subcellular fractions in order to localize exopolyphosphatases (ec 3.6.1.11), triphosphatase (ec 3.6.1.25), inorganic diphosphatase (ec 3.6.1.1), apyrase (ec 3.6.1.5) and glucokinase (ec 2.7.1.2). the highest specific activity of enzymes hydrolyzing polyphosphates was found in cytoplasmic vesicles and membranes. triphosphatase was detected in the periplasmic fraction. ...	1987	2826319
modulating action of cyclic amp on the expression of two sos genes in escherichia coli k-12.	ultraviolet irradiation and cyclic amp treatment produce a synergistic effect on the induction of the cle1 gene (coding for bacteriocin cole1) in wild-type strains of escherichia coli. on the other hand, cyclic amp does not affect the uv-mediated induction of the reca, sfia, and umudc genes. growth in the presence of glucose or glycerol does not affect the factor of amplification of the expression of the cle1 gene in uv-irradiated cells of the wild-type strain. although, in cultures not treated ...	1987	2825953
modulating action of cyclic amp on the expression of two sos genes in escherichia coli k-12.	ultraviolet irradiation and cyclic amp treatment produce a synergistic effect on the induction of the cle1 gene (coding for bacteriocin cole1) in wild-type strains of escherichia coli. on the other hand, cyclic amp does not affect the uv-mediated induction of the reca, sfia, and umudc genes. growth in the presence of glucose or glycerol does not affect the factor of amplification of the expression of the cle1 gene in uv-irradiated cells of the wild-type strain. although, in cultures not treated ...	1987	2825953
opioid receptors inhibit the adenylate cyclase in guinea pig cochleas.	the effects of mu- and delta-preferring agonists on adenylate cyclase activity have been investigated in vitro in homogenates of guinea pig cochleas. morphine, leu-enkephalin, d-ala2, n-methyl-phe4, gly-ol5-enkephalin (dago) and d-ser2-leu-enkephalin-thr (dslet) each inhibited the synthesis of cyclic amp. this effect was reversed by naloxone which had a greater affinity in blocking the effect of the mu-preferring agonists (morphine, dago) than in blocking the effect of the delta-preferring agoni ...	1987	2825909
opioid receptors inhibit the adenylate cyclase in guinea pig cochleas.	the effects of mu- and delta-preferring agonists on adenylate cyclase activity have been investigated in vitro in homogenates of guinea pig cochleas. morphine, leu-enkephalin, d-ala2, n-methyl-phe4, gly-ol5-enkephalin (dago) and d-ser2-leu-enkephalin-thr (dslet) each inhibited the synthesis of cyclic amp. this effect was reversed by naloxone which had a greater affinity in blocking the effect of the mu-preferring agonists (morphine, dago) than in blocking the effect of the delta-preferring agoni ...	1987	2825909
the versatility of hydroxyapatite blocks in maxillofacial surgery.	there is considerable interest at present in the potential role of calcium hydroxyapatite as a biomaterial for bone augmentation in oral and maxillofacial surgery. most of the published work has been on the particulate form, mainly in alveolar ridge procedures. however, hydroxyapatite is also available as solid or porous blocks. the blocks are more predictable in their use than are the particles, and are adaptable and versatile. this paper reviews the biological behaviour of the material and dis ...	2010	2825758
effects of tilomisole, indomethacin and levamisole on regulation of epstein barr virus-induced b cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis.	when activated in autologous mixed leukocyte reactions (auto-mlr) in vitro, t cells from normal individuals produce a suppressor factor(s) which inhibits the epstein-barr virus (ebv)-induced proliferation of normal b cells. in contrast, t cells from patients with rheumatoid arthritis (ra) are deficient in their ability to generate this suppressor factor in auto-mlr. addition of tilomisole (wy-18,251; 33(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) to the auto-mlr (0.1-100 microgram ...	1987	2825478
effects of tilomisole, indomethacin and levamisole on regulation of epstein barr virus-induced b cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis.	when activated in autologous mixed leukocyte reactions (auto-mlr) in vitro, t cells from normal individuals produce a suppressor factor(s) which inhibits the epstein-barr virus (ebv)-induced proliferation of normal b cells. in contrast, t cells from patients with rheumatoid arthritis (ra) are deficient in their ability to generate this suppressor factor in auto-mlr. addition of tilomisole (wy-18,251; 33(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) to the auto-mlr (0.1-100 microgram ...	1987	2825478
virological implications of the use of primates in xenotransplantation.		1987	2823433
virological implications of the use of primates in xenotransplantation.		1987	2823433