Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| vitreous evaluation: a diagnostic challenge. | to categorize vitrectomy cytologic diagnoses and ancillary tests to address appropriate processing of low-volume vitreous samples. | 2015 | 25439597 |
| diffuse large b-cell lymphoma occurring in an ovarian cystic teratoma: expanding the spectrum of large b-cell lymphoma associated with chronic inflammation. | diffuse large b-cell lymphoma associated with chronic inflammation (dlbcl-ci) is a well-recognized entity, originally recorded as pyothorax-associated lymphoma because of the association with artificial pneumothorax. clinically, it is characterized by a mass arising in a long-standing inflammation and by a poor prognosis. recently, dlbcl-ci has been described growing along the wall of a preexisting cyst, without forming a mass. here we describe a case of dlbcl-ci arising in the wall of a mature ... | 2014 | 25439346 |
| infections of the cerebellum. | although the cerebellum can be affected by any infection that also involves other parts of the brain parenchyma, cerebrospinal fluid, or nerve roots, a limited range of infections targets cerebellar structures preferentially. thus, a primarily cerebellar syndrome narrows infectious differential diagnostic considerations. the differential diagnosis of rapidly evolving cerebellar signs suggesting infection includes prescription or illicit drug intoxications or adverse reactions, inflammatory pseud ... | 2014 | 25439297 |
| ultra-endurance exercise induces stress and inflammation and affects circulating hematopoietic progenitor cell function. | although amateur sports have become increasingly competitive within recent decades, there are as yet few studies on the possible health risks for athletes. this study aims to determine the impact of ultra-endurance exercise-induced stress on the number and function of circulating hematopoietic progenitor cells (cpcs) and hematological, inflammatory, clinical, metabolic, and stress parameters in moderately trained amateur athletes. following ultra-endurance exercise, there were significant increa ... | 2015 | 25438993 |
| humanized mouse models of epstein-barr virus infection and associated diseases. | epstein-barr virus (ebv) is a ubiquitous herpesvirus infecting more than 90% of the adult population of the world. ebv is associated with a variety of diseases including infectious mononucleosis, lymphoproliferative diseases, malignancies such as burkitt lymphoma and nasopharyngeal carcinoma, and autoimmune diseases including rheumatoid arthritis (ra). ebv in nature infects only humans, but in an experimental setting, a limited species of new-world monkeys can be infected with the virus. small a ... | 2013 | 25436886 |
| epstein-barr virus sequence variation-biology and disease. | some key questions in epstein-barr virus (ebv) biology center on whether naturally occurring sequence differences in the virus affect infection or ebv associated diseases. understanding the pattern of ebv sequence variation is also important for possible development of ebv vaccines. at present ebv isolates worldwide can be grouped into type 1 and type 2, a classification based on the ebna2 gene sequence. type 1 ebv is the most prevalent worldwide but type 2 is common in parts of africa. type 1 t ... | 2012 | 25436768 |
| hypomethylation and over-expression of the beta isoform of blimp1 is induced by epstein-barr virus infection of b cells; potential implications for the pathogenesis of ebv-associated lymphomas. | b-lymphocyte-induced maturation protein 1 (blimp1) exists as two major isoforms, α and β, which arise from alternate promoters. inactivation of the full length blimp1α isoform is thought to contribute to b cell lymphomagenesis by blocking post-germinal centre (gc) b cell differentiation. in contrast, the shorter β isoform is functionally impaired and over-expressed in several haematological malignancies, including diffuse large b cell lymphomas (dlbcl). we have studied the influence on blimp1β e ... | 2012 | 25436766 |
| arginine methyltransferases are regulated by epstein-barr virus in b cells and are differentially expressed in hodgkin's lymphoma. | although there is increasing evidence that aberrant expression of those enzymes which control protein arginine methylation contribute to carcinogenesis, their de-regulation by oncogenic viruses in primary cells has yet to be reported. we first show that the protein arginine methyltransferases, carm1, prmt1 and prmt5 are strongly expressed in hodgkin reed-sternberg (hrs) cells, and up-regulated in hodgkin's lymphoma (hl) cell lines. given that epstein-barr virus (ebv) can be detected in approxima ... | 2012 | 25436604 |
| similarities between the epstein-barr virus (ebv) nuclear protein ebna1 and the pioneer transcription factor foxa: is ebna1 a "bookmarking" oncoprotein that alters the host cell epigenotype? | ebna1, a nuclear protein expressed in all ebv-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells. ebna1 may induce genetic alterations by upregulating cellular recombinases, production of reactive oxygen species (ros) and affecting p53 levels and function. all these changes may contribute to tumorigenesis. in this overview we focus, however, on the epigenetic alterations elicited by ebna1 by drawing a parallel between ebna1 and the foxa fam ... | 2012 | 25436603 |
| sibship structure and risk of infectious mononucleosis: a population-based cohort study. | present understanding of increased risk of epstein-barr virus (ebv)-related infectious mononucleosis among children of low birth order or small sibships is mainly based on old and indirect evidence. societal changes and methodological limitations of previous studies call for new data. | 2014 | 25436250 |
| hodgkin-like peripheral t-cell lymphoma (ptcl) with preserved hodgkin-like lesions at autopsy: a case report with an interesting clinical course. | the presence of the so-called hodgkin and reed-sternberg (h-rs) like cells may occur in t-cell non-hodgkin lymphoma. reported herein is the autopsy case of hodgkin-like peripheral t-cell lymphoma (ptcl) in a 77-year-old male with gradual submandibular lymph node enlargement. the first biopsy showed hodgkin-like ptcl, initially misdiagnosed as classical hodgkin lymphoma. although he was treated with a regimen of abvd, his disease recurred with cervical lymph node enlargement. a second biopsy show ... | 2015 | 25434605 |
| the v-val subtype epstein-barr virus nuclear antigen 1 promotes cell survival after serum withdrawal. | epstein-barr virus (ebv) can establish latent infection and has been associated with various human cancers. epstein-barr nuclear antigen 1 (ebna1) is the only viral protein that is expressed in all ebv-associated malignant tissues. the n- and c-terminal domains of ebna1, which are connected by internal glycine/alanine-rich short repeat sequences of various sizes, show sequence divergence across ebv strains isolated from around the world. at least five subtypes have been described, according to t ... | 2015 | 25434292 |
| possible infectious causes of spontaneous splenic rupture: a case report. | spontaneous atraumatic splenic rupture is a rare but dramatic occurrence that is most commonly attributed to infection or neoplasia. deciphering the etiology can be challenging with many cases remaining unclear despite full investigation. | 2014 | 25433804 |
| epstein-barr virus persistence and reactivation in neuromyelitis optica. | epstein-barr virus (ebv) infection has been thought to be a key environmental factor in the development of multiple sclerosis (ms). the aim of this study is to investigate the association of ebv infection with neuromyelitis optica (nmo). | 2015 | 25433035 |
| pulmonary lymphomatoid granulomatosis in a 4-year-old girl. | lymphomatoid granulomatosis is a rare lymphoproliferative disease associated with the epstein-barr virus that commonly affects the lung. there is limited literature on cases of pediatric lymphomatoid granulomatosis. half of all cases of lymphomatoid granulomatosis develop during the treatment of leukemia. herein, we describe a case of lymphomatoid granulomatosis in a previously healthy child without leukemia. | 2015 | 25432443 |
| a pediatric case with vasculitis-like viral eruption induced by epstein-barr virus. | 2015 | 25431017 | |
| host genetics of epstein-barr virus infection, latency and disease. | epstein-barr virus (ebv) infects 95% of the adult population and is the cause of infectious mononucleosis. it is also associated with 1% of cancers worldwide, such as nasopharyngeal carcinoma, hodgkin's lymphoma and burkitt's lymphoma. human and cancer genetic studies are now major forces determining gene variants associated with many cancers, including nasopharyngeal carcinoma and hodgkin's lymphoma. host genetics is also important in infectious disease; however, there have been no large-scale ... | 2015 | 25430668 |
| clinicopathological characteristics and rituximab addition to cytotoxic therapies in patients with rheumatoid arthritis and methotrexate-associated large b lymphoproliferative disorders. | to analyse the clinicopathological characteristics and prognosis of 40 rheumatoid arthritis (ra) patients with methotrexate (mtx)-associated large b cell lymphoproliferative disorders (mtx-blpd). | 2015 | 25429725 |
| tracheobronchial anomalies in a patient with schimke immuno-osseous dysplasia (siod). | schimke immuno-osseous dysplasia (siod) is a rare genetic disorder with multiple systemic manifestations. pulmonary manifestations have been described but not well characterized. they are believed to be secondary to decreased elasticity, and include emphysema, pulmonary hypertension and bronchiectasis. we describe a 24-year-old female patient with siod with tracheobronchial anomalies not reported before, including tracheomalacia and a tracheal bronchus with epstein-barr virus (ebv) related leiom ... | 2015 | 25428399 |
| human leukocyte antigen type and posttransplant lymphoproliferative disorder. | posttransplant lymphoproliferative disorder (ptld) is an infrequent but serious complication of solid organ transplantation. early detection and initiation of therapy may improve outcomes. the purpose of this study was to identify human leukocyte antigen (hla) type as risk and prognostic factors for ptld. | 2015 | 25427163 |
| gcn5 inhibits xbp-1s-mediated transcription by antagonizing pcaf action. | cellular unfolded protein response (upr) is induced when endoplasmic reticulum (er) is under stress. xbp-1s, the active isoform of x-box binding protein 1 (xbp-1), is a key regulator of upr. previously, we showed that a histone acetyltransferase (hat), p300/cbp-associated factor (pcaf), binds to xbp-1s and functions as an activator of xbp-1s. here, we identify general control nonderepressible 5 (gcn5), a hat with 73% identity to pcaf, as a novel xbp-1s regulator. both pcaf and gcn5 bind to the s ... | 2015 | 25426559 |
| antiviral treatment of a boy with ebv-associated hydroa vacciniforme. | hydroa vacciniforme is one of the rarest forms of photosensitivity disorders of the skin. effective treatment options are scarce and mainly constitute of strict sun protection. lately, hydroa vacciniforme has been associated with epstein-barr virus infection. we present a patient with hydroa vacciniforme and concomitant previous/chronic epstein-barr virus infection. in this case, antiviral treatment was successful. | 2014 | 25422336 |
| cancer-associated infectious agents and epigenetic regulation. | infectious agents are one of the factors which contribute to cancer development. few examples include human papilloma virus in cervical cancer, hepatitis virus in hepatocellular carcinoma, herpes virus in kaposi's sarcoma, epstein-barr virus in nasopharyngeal carcinoma, human t-cell lymphotropic virus type-1 (htlv-1) in t-cell leukemia and lymphoma, helicobacter pylori in gastric cancer. these agents cause genomic instability in the host and most of them affect host immune system. infectious age ... | 2015 | 25421669 |
| an eschar and violaceous nodules as the presenting signs of lymphomatoid granulomatosis. | lymphomatoid granulomatosis (lyg) is a rare b-cell lymphoproliferative disorder associated with infection by epstein-barr virus (ebv). the lung is the most common site of involvement, but lyg may initially manifest in the skin. lyg has been associated with immune dysregulation. treatment regimens are not well-defined, but clinical trials targeting ebv have been successful. we report a 31-year-old male with lyg who presented with cutaneous symptoms. the skin biopsy was devoid of b-cells and non-r ... | 2014 | 25419752 |
| contemporary management and classification of hepatic leiomyosarcoma. | hepatic leiomyosarcomas are rare soft-tissue tumours. the majority of lesions previously considered as leiomyosarcomas have been identified as gastrointestinal stromal tumours (gists). consequently, understanding of the role of liver resection for true leiomyosarcoma is limited, a fact that is exacerbated by the increasing recognition of leiomyosarcoma subtypes. this study presents data on the outcomes of liver resection for leiomyosarcoma and suggests an algorithm for its pathological assessmen ... | 2015 | 25418451 |
| epstein-barr virus and burkitt lymphoma. | in 1964, a new herpesvirus, epstein-barr virus (ebv), was discovered in cultured tumor cells derived from a burkitt lymphoma (bl) biopsy taken from an african patient. this was a momentous event that reinvigorated research into viruses as a possible cause of human cancers. subsequent studies demonstrated that ebv was a potent growth-transforming agent for primary b cells, and that all cases of bl carried characteristic chromosomal translocations resulting in constitutive activation of the c-myc ... | 2014 | 25418195 |
| plasma epstein-barr virus dna as a biomarker for nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is common in southern china and southeast asia. epstein-barr virus (ebv) infection is an important etiology for npc, and ebv genome can be detected in almost all tumor tissues of npc in this region. plasma ebv dna, when quantitatively analyzed using real-time polymerase chain reaction (pcr), has been developed as a biomarker for npc. in this review, the different clinical applications of plasma ebv dna in the management of npc, including screening, monitoring, and ... | 2014 | 25418194 |
| epstein-barr virus and nasopharyngeal carcinoma. | since its discovery 50 years ago, epstein-barr virus (ebv) has been linked to the development of cancers originating from both lymphoid and epithelial cells. approximately 95% of the world's population sustains an asymptomatic, life-long infection with ebv. the virus persists in the memory b-cell pool of normal healthy individuals, and any disruption of this interaction results in virus-associated b-cell tumors. the association of ebv with epithelial cell tumors, specifically nasopharyngeal carc ... | 2014 | 25418193 |
| epstein-barr virus and the origin of hodgkin lymphoma. | although epstein-barr virus (ebv) is present in the malignant hodgkin/reed-sternberg (hrs) cells of a proportion of cases of classical hodgkin lymphoma (chl), how the virus contributes to the pathogenesis of this disease remains poorly defined. it is clear from the studies of other ebv-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. this article reviews what is known about the contribution of ebv to the pathogene ... | 2014 | 25418190 |
| [probable meningoencephalitis due to epstein-barr virus in a female patient with human immunodeficiency virus]. | 2014 | 25418148 | |
| belatacept for kidney transplant recipients. | most people who receive a kidney transplant die from either cardiovascular disease or cancer before their transplant fails. the most common reason for someone with a kidney transplant to lose the function of their transplanted kidney necessitating return to dialysis is chronic kidney transplant scarring. immunosuppressant drugs have side effects that increase risks of cardiovascular disease, cancer and chronic kidney transplant scarring. belatacept may provide sufficient immunosuppression while ... | 2014 | 25416857 |
| relapsing pityriasis rosea. | to assess the prevalence of relapses of pityriasis rosea (pr), a retrospective cohort study investigated all pr cases diagnosed in genoa between 2000 and 2013 and followed them up to today. of 570 cases, 21 (3.7%) relapsed. most of them had a single episode, but 4 had two episodes and 2 had three episodes. the herald patch was always absent, size and number of the lesions were reduced, and duration was shorter than that of the primary episodes. constitutional symptoms were present, though less s ... | 2014 | 25412725 |
| murine gammaherpesvirus-68 (mhv-68) is not horizontally transmitted amongst laboratory mice by cage contact. | murine gammaherpesvirus-68 (mhv-68), a natural pathogen of mice, is being evaluated as a model of epstein barr virus (ebv) infection for use in investigation of the effects of immunomodulatory therapy on herpesvirus pathogenesis in humans. immunosuppressive agents are used for treatment of a variety of autoimmune diseases as well as for prevention of tissue rejection after organ transplantation and can result in recrudescence of latent herpesvirus infections. prior to examination of mhv-68 as a ... | 2015 | 25412621 |
| cellular differentiation regulator blimp1 induces epstein-barr virus lytic reactivation in epithelial and b cells by activating transcription from both the r and z promoters. | epstein-barr virus (ebv) maintains a lifelong latent infection within a subset of its host's memory b cells, while lytic ebv replication takes place in plasma cells and differentiated epithelial cells. therefore, cellular transcription factors, such as blimp1, that are key mediators of differentiation likely contribute to the ebv latent-to-lytic switch. previous reports showed that ectopic blimp1 expression induces reactivation in some ebv-positive (ebv(+)) b-cell lines and transcription from zp ... | 2015 | 25410866 |
| bglf4 kinase modulates the structure and transport preference of the nuclear pore complex to facilitate nuclear import of epstein-barr virus lytic proteins. | bglf4 kinase, the only ser/thr protein kinase encoded by the epstein-barr virus (ebv) genome, phosphorylates multiple viral and cellular substrates to optimize the cellular environment for viral dna replication and the nuclear egress of nucleocapsids. previously, we found that nuclear targeting of bglf4 is through direct interaction with the fg repeat-containing nucleoporins (fg-nups) nup62 and nup153 independently of cytosolic transport factors. here, we investigated the regulatory effects of b ... | 2015 | 25410863 |
| cd137 expression is induced by epstein-barr virus infection through lmp1 in t or nk cells and mediates survival promoting signals. | to clarify the mechanism for development of epstein-barr virus (ebv)-positive t- or nk-cell neoplasms, we focused on the costimulatory receptor cd137. we detected high expression of cd137 gene and its protein on ebv-positive t- or nk-cell lines as compared with ebv-negative cell lines. ebv-positive cells from ebv-positive t- or nk-cell lymphoproliferative disorders (ebv-t/nk-lpds) patients also had significantly higher cd137 gene expression than control cells from healthy donors. in the presence ... | 2014 | 25409517 |
| dce-mri assessment of the effect of epstein-barr virus-encoded latent membrane protein-1 targeted dnazyme on tumor vasculature in patients with nasopharyngeal carcinomas. | ebv-encoded latent membrane protein 1 (ebv-lmp1) is an important oncogenic protein for nasopharyngeal carcinoma (npc) and has been shown to engage a plethora of signaling pathways. correspondingly, an lmp1-targeted dnazyme was found to inhibit the growth of npc cells both in vivo and in vitro by suppressing cell proliferation and inducing apoptosis. however, it remains unknown whether an lmp1-targeted dnazyme would affect the vasculature of npc. dynamic contrast-enhanced magnetic resonance imagi ... | 2014 | 25407966 |
| in acpa-positive ra patients, antibodies to ebna35-58cit, a citrullinated peptide from the epstein-barr nuclear antigen-1, strongly cross-react with the peptide β60-74cit which bears the immunodominant epitope of citrullinated fibrin. | although several infectious agents and particularly epstein-barr virus (ebv) have been suspected to be involved in aetiology of rheumatoid arthritis (ra), their role still remains elusive. almost 80% of ra sera contain antibodies to citrullinated proteins/peptides. among them, the autoantibodies to citrullinated human fibrinogen (ahfiba) are composed of two non-cross-reactive subsets directed to immunodominant epitopes borne by the α36-50cit and β60-74cit fibrin peptides. ra sera also contain an ... | 2015 | 25407647 |
| acneiform primary cutaneous cd4-positive small/medium pleomorphic t-cell lymphoma with prominent necrosis. | primary cutaneous cd4-positive small/medium pleomorphic t-cell lymphoma (smptcl) is an indolent form of cutaneous lymphoma that usually presents in solitary fashion and is histopathologically characterized by nodular infiltration of small- to medium-sized pleomorphic t-cells. we report the case of a patient who presented with a 5-year history of acneiform lesions on his face. histopathologic examination of two lesions revealed a nodular infiltrate of small to medium-sized lymphocytes with necros ... | 2015 | 25407448 |
| [clinical and laboratory characteristics of chronic active epstein-barr virus infection in children]. | to study the clinical and laboratory characteristics of chronic active epstein-barr virus (ebv) infection (caebv) in children and to provide a basis for the diagnosis and treatment of caebv. | 2014 | 25406547 |
| epstein-barr virus and human papillomavirus infections and genotype distribution in head and neck cancers. | to investigate the prevalence, genotypes, and prognostic values of epstein-barr virus (ebv) and human papillomavirus (hpv) infections in japanese patients with different types of head and neck cancer (hnc). | 2014 | 25405488 |
| quantitative nucleic acid amplification methods for viral infections. | over the past 2 decades there have been substantial improvements in the methods used to quantify viral nucleic acid in body fluids and in our understanding of how to use viral load measurements in the diagnosis and management of patients with a number of viral infections. these methods are now integrated into a wide range of diagnostic and treatment guidelines and commonly deployed in a variety of clinical settings. | 2015 | 25403817 |
| primary diffuse large b-cell lymphoma of the ovary is of a germinal centre b-cell-like phenotype. | primary ovarian lymphoma is rare. to better understand the clinicopathological and molecular features of these tumours, we studied 14 patients (age range 13 to 74 years, mean 46.9 years) with non-hodgkin's lymphoma who initially presented with an ovarian tumour. the clinicopathological features were reviewed and tissue samples were studied by immunohistochemistry and for immunoglobulin gene rearrangement, presence of epstein barr virus and for myc and bcl-2 rearrangements by fluorescence in situ ... | 2015 | 25403088 |
| epstein-barr virus latent membrane protein 2a suppresses the expression of her2 via a pathway involving twist and yb-1 in epstein-barr virus-associated gastric carcinomas. | to explore her2 expression in epstein-barr virus-associated gastric carcinoma (ebvagc) and the possible mechanisms causing down-regulation of her2 expression in ebvagc, we first evaluated her2 and lmp2a expression on a clinicopathological-features matched cohort including 78 ebvagc and 216 ebv-negative gastric carcinoma (ebvngc) cases by immunohistochemistry. cases with high her2 expression in ebvagc were significantly less than in ebvngc (5.1% versus 23.7%; p<0.001), and none of the 34 lmp2a+ e ... | 2015 | 25402957 |
| hepatosplenic hodgkin lymphoma without lymphadenopathy following reversible methotrexate-associated lymphoproliferative disorder. | lymphoproliferative disorders (lpds) occur more frequently in rheumatoid arthritis (ra) patients treated with immunosuppressive agents than in the non-ra population. however, the various forms of disease progression have not yet been elucidated in detail. we encountered a case of epstein-barr virus (ebv)-positive atypical polymorphous lpd in the cervical and intraabdominal lymph nodes with hepatosplenomegaly in an 88-year-old female with ra who had taken infliximab and methotrexate (mtx) for six ... | 2017 | 25401225 |
| human herpesvirus-6 and epstein-barr virus infections at different histopathological grades of oral squamous cell carcinomas. | the aim of this study was to determine the prevalence and viral load of epstein-barr virus (ebv) and human herpesvirus-6 (hhv-6) in different histopathologic grades of oral squamous cell carcinoma (oscc). | 2014 | 25400880 |
| systemic epstein-barr virus positive t-cell lymphoproliferative disease of childhood with hemophagocytic syndrome. | epstein-barr virus (ebv) associated lymphoproliferative disease (lpd) are commonly derived from b-cells, however, it is becoming more and more apparently that ebv can also infect t-lymphocytes. systemic ebv positive t-cell lpd of childhood is rare and characterized by an extremely aggressive course and poor prognosis. here, we report a 22-year-old female of systemic ebv positive tlpd with acute ebv infection and review the clinical features of this disorder. a 22-year-old previously healthy fema ... | 2014 | 25400806 |
| systemic epstein-barr virus-positive t/natural killer-cell lymphoproliferative disorder: a case report and review of literature. | systemic epstein-barr virus-positive t/natural killer-cell lymphoproliferative disorder (ebv + lpd) has predominantly been observed among pediatric patients as a life-threatening condition. the present study presents a rare case of ebv + lpd in an adult with good outcome. this patient's history is more than 2 years and her condition was stable. she received 6 cycles of chemotherapy cyclophosphamide/doxorubicin/vincristine/prednisolone (chop). the evaluation was complete remission. the low levels ... | 2014 | 25400787 |
| epstein-barr virus-host cell interactions: an epigenetic dialog? | here, we wish to highlight the genetic exchange and epigenetic interactions between epstein-barr virus (ebv) and its host. ebv is associated with diverse lymphoid and epithelial malignancies. their molecular pathogenesis is accompanied by epigenetic alterations which are distinct for each of them. while lymphoblastoid cell lines derived from b cells transformed by ebv in vitro are characterized by a massive demethylation and euchromatinization of the viral and cellular genomes, the primarily mal ... | 2014 | 25400657 |
| nuclear factor κb represses the expression of latent membrane protein 1 in epstein-barr virus transformed cells. | to investigate the role of nuclear factor κb (nf-κb) in the regulation of epstein-barr virus (ebv) latent membrane protein 1 (lmp1) in ebv transformed cells. | 2014 | 25396119 |
| reduced response to epstein-barr virus antigens by t-cells in systemic lupus erythematosus patients. | epstein-barr virus (ebv) has for long been associated with systemic lupus erythematosus (sle). in this study, we investigated the levels of latent and lytic antigen ebv-specific t-cells and antibodies in sle patients. | 2014 | 25396062 |
| cytokine production and antigen recognition by human mucosal homing conjunctival effector memory cd8+ t cells. | conjunctival epithelial t cells are dominated by cd3(+)cd56-tcrαβ(+)cd8αβ(+) lymphocytes. in this study we explored the antigen experience status, mucosal homing phenotype, cytokine expression, and viral antigen recognition of conjunctival epithelial cd8(+) t cells from healthy individuals. | 2014 | 25395484 |
| [aberrant reparative tissue remodeling: histopathology and molecular pathology]. | not only tumorous infiltrations can lead to destruction of parenchymal organs but also the aberrant proliferation and matrix production of mesenchymal cells and vessels during a dysregulated repair attempt. this fibrogenesis is the result of a complex pathogenesis, which can be investigated in animal models but also in situ to harvest new biomarkers. this article deals particularly with the second method and summarizes molecular pathological findings in various model diseases for aberrant repara ... | 2014 | 25394975 |
| haemophagocytic syndrome and elevated ebv load as initial manifestation of hodgkin lymphoma in a hiv patient: case report and review of the literature. | in hiv patients, haemophagocytic syndrome (hps) may occur in the presence of cancer, concomitant viral infection, hiv primo-infection or at the initiation of highly active antiretroviral therapy (haart). hodgkin lymphoma remains a rare cause of hps. we describe a case of hps with very high epstein barr virus (ebv) load in a hiv patient as initial manifestation of hodgkin lymphoma. | 2014 | 25394154 |
| the translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against ebv-driven lymphoproliferative disease. | treatment options for patients with epstein-barr virus-driven lymphoproliferative diseases (ebv-lpd) are limited. chemo-immunotherapeutic approaches often lead to immune suppression, risk of lethal infection and ebv reactivation, thus it is essential to identify agents that can deliver direct anti-tumor activity while preserving innate and adaptive host immune surveillance. silvestrol possesses direct anti-tumor activity in multiple hematologic malignancies while causing minimal toxicity to norm ... | 2015 | 25393910 |
| in situ hybridisation for epstein-barr virus as a differential diagnostic tool for t- and natural killer/t-cell lymphomas in non-immunocompromised patients. | epstein-barr virus (ebv) is a ubiquitous human herpesvirus infecting over 90% of humans and the infection persists for life. although most people are asymptomatic, ebv infection may cause a continuous range of symptoms from transient to severe and protracted diseases depending on the immunological response of the individuals. ebv infects primarily b lymphocytes and rarely t and natural killer (nk) cells. it is implicated in around 1% of human tumours with the majority being haematological malign ... | 2014 | 25393247 |
| standardization of nucleic acid tests for clinical measurements of bacteria and viruses. | nucleic acid-based tests for infectious diseases currently used in the clinical laboratory and in point-of-care devices are diverse. measurement challenges associated with standardization of quantitative viral load testing are discussed in relation to human cytomegalovirus, bk virus, and epstein-barr virus, while the importance of defining the performance of qualitative methods is illustrated with mycobacterium tuberculosis and influenza virus. the development of certified reference materials wh ... | 2015 | 25392365 |
| human interferon regulatory factor 5 homologous epitopes of epstein-barr virus and mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients. | a large number of reports indicate the association of epstein-barr virus (ebv), and mycobacterium avium subsp. paratuberculosis (map) with multiple sclerosis (ms). | 2015 | 25392335 |
| epstein-barr virus-specific intrathecal oligoclonal igg production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies. | the purpose of this study was to investigate intrathecal production and affinity distributions of epstein-barr virus (ebv)-specific antibodies in multiple sclerosis (ms) and controls. | 2014 | 25391491 |
| [pulmonary lymphoepithelioma-like carcinoma; report of a case]. | a 66-year-old male was referred to our hospital due to an abnormal chest shadow in the left lung detected on a medical examination. chest computed tomography(ct) revealed a round mass of 40 mm in diameter in the left s10. positron emission tomography (pet) scan showed fluorodeoxy glucose (fdg) accumulation and surgical biopsy was done. the intraoperative frozen histopathological diagnosis was mucosal associated lymphoid tissue( malt) lymphoma or pseudoinflammatory tumor. by postoperative patholo ... | 2014 | 25391478 |
| diagnosis of a multicentric extranodal nasal-type natural killer t-cell lymphoma made with an anterior chamber tap. | to report the case of an unusual multicentric epstein-barr virus (ebv)-associated extranodal nasal-type natural killer t-cell lymphoma masquerading as unilateral panuveitis, diagnosed with an anterior chamber tap. | 2012 | 25390710 |
| multifocal choroiditis secondary to the reactivation of epstein-barr virus. | to describe a case of multifocal choroiditis associated with epstein-barr virus reactivation in a patient who had previously had documented infectious mononucleosis. | 2011 | 25390436 |
| epstein-barr infection of the retina: case report and review of the literature. | the purpose of this study is to describe a presumed case of epstein-barr virus (ebv) infection of the retina in a 65-year-old female with sudden bilateral vision loss. | 2011 | 25389670 |
| diverse clinicopathologic features in human herpesvirus 8-associated lymphomas lead to diagnostic problems. | human herpesvirus 8 (hhv8)-associated lymphomas are uncommon, mainly affect men infected with the human immunodeficiency virus (hiv), and usually have a poor prognosis. we sought to characterize the hhv8+ lymphomas seen at our institution since the mid-1990s. | 2014 | 25389336 |
| epstein-barr virus-positive pleural effusion: clinical features, cytomorphologic characteristics, and flow cytometric immunophenotyping. | the etiology of pleural effusions (pes) varies, and a percentage of pes remains unexplained despite an intensive workup. one previous study documented a high prevalence of epstein-barr virus (ebv)-dna in unselected and unexplained pes. our aim is to characterize the clinical and cytomorphologic features of ebv-associated pes, which have not been described. | 2014 | 25389332 |
| proven epstein-barr encephalitis with negative ebv-dna load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia. | we report a case of ebv encephalitis in a seven-yr-old child with ph+ all. two months after an allogeneic hsct from his hla mismatched mother, the patient showed an altered sensorium, generalized seizures, and a left hemiparesis. brain mri demonstrated multiple lesions highly suggestive for viral encephalitis. blood and csf pcr analyses were negative for the most common viruses involved in immunocompromised patients including ebv. a cerebral biopsy was performed, which showed intense gliosis and ... | 2015 | 25388950 |
| epstein-barr virus in gastric carcinoma. | the epstein-barr virus (ebv) is detected in about 10% of gastric carcinoma cases throughout the world. in ebv-associated gastric carcinoma, all tumor cells harbor the clonal ebv genome. gastric carcinoma associated with ebv has distinct clinicopathological features, occurs predominately in men and in younger-aged individuals, and presents a generally diffuse histological type. most cases of ebv-associated gastric carcinoma exhibit a histology rich in lymphocyte infiltration. the immunological re ... | 2014 | 25386788 |
| epidemiology of meningitis in an hiv-infected ugandan cohort. | there is limited understanding of the epidemiology of meningitis among human immunodeficiency virus (hiv)-infected populations in sub-saharan africa. we conducted a prospective cohort study of hiv-infected adults with suspected meningitis in uganda, to comprehensively evaluate the etiologies of meningitis. intensive cerebrospiral fluid (csf) testing was performed to evaluate for bacterial, viral, fungal, and mycobacterial etiologies, including neurosyphilis,16s ribosomal dna (rdna) polymerase ch ... | 2015 | 25385864 |
| epstein-barr virus replicating in epithelial cells. | 2014 | 25385596 | |
| the etiology of juvenile idiopathic arthritis. | over the years, the commonly used term to describe juvenile idiopathic arthritis (jia) has changed. by definition, jia includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. jia pathogenesis is still poorly understood: the interaction between environmental factors and multiple genes has been proposed as the most relevant working mechanism to the development of jia. the concept that various microbes that colonize or infect ... | 2015 | 25384710 |
| posttransplantation lymphoproliferative disease: proposed imaging classification. | posttransplantation lymphoproliferative disease (ptld) is the second most common tumor in adult transplant recipients. most cases of ptld are attributed to epstein-barr virus. decreased levels of immunosurveillance against this tumor virus as a result of immunosuppressive regimens are thought to account for most cases of ptld. histologically, ptld ranges from relatively benign lymphoid hyperplasia to poorly differentiated lymphoma, and tissue sampling is required to establish the subtype. the fr ... | 2014 | 25384299 |
| retinopathy in a patient with acute epstein-barr virus infection: follow-up analysis using spectral domain optical coherence tomography. | to describe the clinical findings, diagnostics, and differential diagnosis in a patient with retinopathy in acute systemic epstein-barr virus (ebv) infection. | 2015 | 25383851 |
| epstein-barr virus-associated t/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/t-cell lymphoma but shows distinctive stem cell-like phenotype. | we performed gene expression profiling in epstein-barr virus (ebv)-associated t/natural killer (nk)-cell lymphoproliferative disorder in children and young adults (tnklpdc) in order to understand the molecular pathways deregulated in this disease and compared it with nasal-type nk/t-cell lymphoma (nktl). the molecular and phenotypic signature of tnklpdc is similar to nktl, with overexpression of p53, survivin and ezh2. down-regulation of ezh2 in tnklpdc cell lines led to an increase in apoptosis ... | 2015 | 25382618 |
| hypermethylation of the tumor suppressor gene prdm1/blimp-1 supports a pathogenetic role in ebv-positive burkitt lymphoma. | prdm1/blimp-1 is a tumor suppressor gene in the activated b-cell subtype of diffuse large b-cell lymphomas. its inactivation contributes to pathogenesis in this setting by impairing terminal b-cell differentiation induced by constitutive nuclear factor-κb activation. the role of prdm1 in burkitt lymphoma (bl) lymphomagenesis is not known. here we identified hypermethylation of the promoter region and exon 1 of prdm1 in all six epstein-barr virus (ebv)-positive bl cell lines and 12 of 23 (52%) pr ... | 2014 | 25382611 |
| clonal epstein-barr virus-positive mucocutaneous ulcer mimicking a mature b-cell lymphoma in a patient with mycophenolate-induced immune suppression. | 2015 | 25379620 | |
| overlapping guillain-barré syndrome and bickerstaff's brainstem encephalitis associated with epstein barr virus. | a flaccid tetraparesis in bickerstaff's brainstem encephalitis (bbe) is presumed to be a sign of overlapping guillain-barré syndrome (gbs). in addition, bbe and fisher syndrome, which are clinically similar and are both associated with the presence of the immunoglobulin g anti-gq1b antibody, represent a specific autoimmune disease with a wide spectrum of symptoms that include ophthalmoplegia and ataxia. a 2-year-old boy presented with rapidly progressive ophthalmoplegia, ataxia, hyporeflexia, we ... | 2014 | 25379047 |
| expression of the epidermodysplasia verruciformis-associated genes ever1 and ever2 is activated by exogenous dna and inhibited by lmp1 oncoprotein from epstein-barr virus. | ever1 and ever2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (hpv) infection. it is unknown whether their products control the infection of other viruses. here, we show that the expression of both genes in b cells is activated immediately after epstein-barr virus (ebv) infection, whereas at later stages, it is strongly repressed via activation of the nf-κb signaling pathway by latent membrane protein 1 (lmp1). ectopic expression of ever ... | 2015 | 25378492 |
| managing the challenge of ptld in liver and bowel transplant recipients. | post-transplant lymphoproliferative disorder (ptld) remains a common complication of liver and bowel transplantion. the ubiquity of epstein-barr virus (ebv) combined with engraftment of organs rich with lymphatic tissue and the requirement of highly immunosuppressive regimens are factors that account for the high frequency and poor prognosis of ptld in this population. early detection of the virus followed by pre-emptive reduction of immunosuppression are essential components in the management o ... | 2015 | 25377273 |
| histopathologic and immunohistological evaluation of anaplastic large cell lymphoma with epstein-barr virus in an orangutan (pongo pygmaeus). | an 18-month-old female orangutan (pongo pygmaeus) died after exhibiting fever, cough, and rapid breathing. | 2015 | 25376634 |
| autoimmune lymphoproliferative syndrome and epstein-barr virus-associated lymphoma: an adjunctive diagnostic role for monitoring ebv viremia? | background. autoimmune lymphoproliferative syndrome (alps) is a genetic disorder of lymphocyte homeostasis due to defects in fas-mediated apoptosis. alps is characterized by childhood onset of chronic lymphadenopathy and splenomegaly, autoimmunity, an expanded population of double-negative t cells (dntcs), and an increased risk of lymphoma. this propensity for lymphoma in alps is not well understood. it is possible that lymphomagenesis in some of these patients may result from epstein-barr virus ... | 2013 | 25374737 |
| nasopharyngeal carcinoma presenting with rapidly progressive severe visual disturbance: a case report. | nasopharyngeal carcinoma is one of the most difficult tumors to diagnose correctly at the initial phase because of the occasional lack of nasal symptoms. the perineural spread of the trigeminal nerve is one of the most common and important routes in the intracranial paracavernous extension of nasopharyngeal carcinoma, but visual loss is very rare. | 2014 | 25373786 |
| sequence variation of epstein-barr virus (ebv) bcrf1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma. | to characterize the sequence variation and the potential implication of the epstein-barr virus (ebv) oncogene in lymphoma, bamhi-c fragment rightward reading frame 1 (bcrf1) was sequenced in different types of ebv-positive lymphoma in northern china, and polymorphisms were compared with previous variation data from other malignancies. the dominate subtype of bcrf1 in ebv-positive lymphoma was the b95-8 prototype, and a mutation in the signal peptide was more strongly associated with hodgkin's ly ... | 2015 | 25373543 |
| correlates of illness severity in infectious mononucleosis. | understanding the spectrum and frequencies of epstein-barr virus (ebv) complications and markers of illness severity in immunocompetent patients with primary ebv infection will inform management of patients with ebv-related illnesses. | 2014 | 25371691 |
| pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma in a case of cd56-positive cytotoxic t-cell lymphoma. | we present the case of an 84-year-old patient with a cutaneous cd56 positive cytotoxic t-cell lymphoma associated with substantial pseudocarcinomatous hyperplasia mimicking squamous cell carcinoma (scc). the patient presented with a 7-month history of several progressive, ulcerated plaques on his right forearm. an initial biopsy showed changes consistent with a diagnosis of scc for which the patient underwent surgical treatment. several months later, the patient developed recurrent ulcerated pla ... | 2015 | 25370871 |
| high efficiency ex vivo cloning of antigen-specific human effector t cells. | while cloned t cells are valuable tools for the exploration of immune responses against viruses and tumours, current cloning methods do not allow inferences to be made about the function and phenotype of a clone's in vivo precursor, nor can precise cloning efficiencies be calculated. additionally, there is currently no general method for cloning antigen-specific effector t cells directly from peripheral blood mononuclear cells, without the need for prior expansion in vitro. here we describe an e ... | 2014 | 25368986 |
| epstein-barr virus infection mimicking drug-induced hepatitis in a critically ill patient during antituberculosis therapy. | although hepatitis is frequently observed during antituberculosis (anti-tb) therapy, acute viral hepatitis should be ruled out first, especially in the endemic areas. in addition to common types of viral hepatitis, ie, hepatitis a, hepatitis b, and hepatitis c viruses, epstein-barr virus (ebv) may result in hepatitis in some cases. | 2014 | 25368656 |
| the interplay of host genetic factors and epstein-barr virus in the development of nasopharyngeal carcinoma. | the interplay between host cell genetics and epstein-barr virus (ebv) infection contributes to the development of nasopharyngeal carcinoma (npc). understanding the host genetic and epigenetic alterations and the influence of ebv on cell signaling and host gene regulation will aid in understanding the molecular pathogenesis of npc and provide useful biomarkers and targets for diagnosis and therapy. in this review, we provide an update of the oncogenes and tumor suppressor genes associated with np ... | 2014 | 25367335 |
| micrornas in nasopharyngeal carcinoma. | micrornas (mirnas) provide insight into both the biology and clinical behavior of many human cancers, including nasopharyngeal carcinoma (npc). the dysregulation of mirnas in npc results in a variety of tumor-promoting effects. furthermore, several mirnas are prognostic markers for npc. in addition to cellular mirnas, npc samples also often contain mirnas encoded by epstein-barr virus, and these mirnas may impact npc biology by targeting both cellular and viral genes. given their numerous putati ... | 2014 | 25367334 |
| epstein-barr virus at 50-future perspectives. | the special november and december issues of the chinese journal of cancer celebrate the 50th anniversary of the discovery of epstein-barr virus (ebv) with a series of reviews covering the association of the virus with various cancers, with special emphasis on the role of ebv in the pathogenesis of nasopharyngeal cancer (npc). the restricted geographic prevalence of npc along with the tumor's consistent association with ebv infection has fascinated scientists and clinicians ever since it was firs ... | 2014 | 25367333 |
| viruses and disease: emerging concepts for prevention, diagnosis and treatment. | viruses cause a wide range of human diseases, ranging from acute self-resolving conditions to acute fatal diseases. effects that arise long after the primary infection can also increase the propensity for chronic conditions or lead to the development of cancer. recent advances in the fields of virology and pathology have been fundamental in improving our understanding of viral pathogenesis, in providing improved vaccination strategies and in developing newer, more effective treatments for patien ... | 2015 | 25366544 |
| clinical & immunological profile of newly diagnosed patients with youth onset diabetes mellitus. | there has been a rise in the incidence of diabetes mellitus in the younger population of india. there are limited data available on the immunological profile of youth onset diabetes mellitus (dm) especially in type 2. therefore, this study was undertaken to evaluate the clinical and immunological profile of youth onset dm in north india. | 2014 | 25366202 |
| prevalence and characteristics of epstein-barr virus-associated gastric cancer in iran. | gastric cancer (gc) is the second leading cause of cancer-related deaths worldwide and is the most frequent cancer in iran. epstein-barr virus (ebv) has been shown to be associated with gastric cancer. the present study was carried out to investigate the prevalence of epstein-barr virus (ebv) associated gastric cancer among iranian patients. | 2014 | 25365618 |
| current status of treatment for primary effusion lymphoma. | primary effusion lymphoma (pel) is a rare and aggressive b-cell non-hodgkin's lymphoma that usually presents with malignant effusions without tumor masses. an extracavitary or solid variant of pel has also been described. human herpes virus 8/kaposi sarcoma-associated herpes virus (hhv-8/kshv) is universally associated with the pathogenesis of pel. more than 70% of cases occur with concurrent epstein-barr virus infection, but its relation to the pathogenesis is unknown. patients are found in the ... | 2014 | 25364646 |
| post-transplant lymphoproliferative disorder presenting as a tumor adjacent to the renal allograft: a case report and review of the literature. | post-transplant lymphoproliferative disorder (ptld) is a potentially fatal complication of solid organ transplantation. the current report presents the case of a 42-year-old male who developed ptld within the first year following renal transplantation. the disorder manifested as a tumor adjacent to the lower pole of the renal allograft and resulted in urinary obstruction. durable complete remission was achieved as a result of surgical resection followed by a reduction in immunosuppression and lo ... | 2014 | 25364435 |
| unusual presentation of duodenal plasmablastic lymphoma in an immunocompetent patient: a case report and literature review. | plasmablastic lymphoma (pbl) is a rare and recently described entity of large b-cell lymphoma. it predominantly occurs in the oral cavity of human immunodeficiency virus (hiv)-positive patients and exhibits a highly aggressive clinical behavior without effective treatment. recently, sporadic cases describing pbl in extraoral locations of hiv-negative patients have been reported; frequently in patients with underlying immunosuppressive states. to develop the understanding of pbl, the current stud ... | 2014 | 25364423 |
| the role of ebv in the pathogenesis of burkitt's lymphoma: an italian hospital based survey. | the exact worldwide incidence of burkitt's lymphoma is not known. there are three distinct clinical variants of burkitt's lymphoma, each manifesting differences in epidemiology, clinical presentation, morphology, biology and genetic features: the endemic (african), the sporadic (non-endemic), and the immunodeficiency-associated form. in particular, we reported data regarding burkitt's lymphoma incidence in the world and across different european countries. finally, we described clinic-pathologic ... | 2014 | 25364378 |
| epstein-barr virus positive inflammatory pseudotumor of the liver: report of a challenging case and review of the literature. | inflammatory pseudotumor (ipt) is an uncommon, benign lesion of unclear etiology, which is sometimes associated with epstein-barr virus (ebv). in this study, we discuss a case of hepatic ebv positive ipt and discuss mimickers, prognosis, and treatment. the case we describe was located in the liver and composed of a mixture of spindle cells and polymorphic inflammatory cells with areas of necrosis. the spindle cells were negative for cam5.2, alk1, cd21, cd23, cd35, actin, s-100, and cd34. ebv-enc ... | 2014 | 25361938 |
| ebv-driven lmp1 and ifn-γ up-regulate pd-l1 in nasopharyngeal carcinoma: implications for oncotargeted therapy. | pd-l1 expression is a feature of epstein-barr virus (ebv) associated malignancies such as nasopharyngeal carcinoma (npc). here, we found that ebv-induced latent membrane protein 1 (lmp1) and ifn-γ pathways cooperate to regulate programmed cell death protein 1 ligand (pd-l1). expression of pd-l1 was higher in ebv positive npc cell lines compared with ebv negative cell lines. pd-l1 expression could be increased by exogenous and endogenous induction of lmp1 induced pd-l1. in agreement, expression o ... | 2014 | 25361008 |
| role of atm in the formation of the replication compartment during lytic replication of epstein-barr virus in nasopharyngeal epithelial cells. | epstein-barr virus (ebv), a type of oncogenic herpesvirus, is associated with human malignancies. previous studies have shown that lytic reactivation of ebv in latently infected cells induces an atm-dependent dna damage response (ddr). the involvement of atm activation has been implicated in inducing viral lytic gene transcription to promote lytic reactivation. its contribution to the formation of a replication compartment during lytic reactivation of ebv remains poorly defined. in this study, t ... | 2015 | 25355892 |
| t cell epitope clustering in the highly immunogenic bzlf1 antigen of epstein-barr virus. | polymorphism in the human leukocyte antigen (hla) loci ensures that the cd8(+) t cell response to viruses is directed against a diverse range of antigenic epitopes, thereby minimizing the impact of virus escape mutation across the population. the bzlf1 antigen of epstein-barr virus is an immunodominant target for cd8(+) t cells, but the response has been characterized only in the context of a limited number of hla molecules due to incomplete epitope mapping. we have now greatly expanded the numb ... | 2015 | 25355876 |