Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| enhancement of hematopoietic response of mice by subcutaneous administration of lactobacillus casei. | mice that had received heat-killed lactobacillus casei (lc 9018) subcutaneously (s.c.) showed enhanced resistance to systemic (i.e., intravenous) infection with listeria monocytogenes, but the antilisterial resistance of mice was less augmented by s.c. administration of propionibacterium acnes ("corynebacterium parvum"). though there was little change in the total number of splenic leukocytes after s.c. administration of lc 9018, the monocyte-macrophage ratio increased after treatment, reaching ... | 1986 | 3082755 |
| calcium-dependent and -independent tumoricidal activities of polymorphonuclear leukocytes induced by a linear beta-1,3-d-glucan and phorbol myristate acetate in mice. | some antitumor immunomodulators, such as a linear beta-1,3-d-glucan from alcaligenes faecalis var. myxogenes ifo 13140 (tak), induce potent tumoricidal activity of polymorphonuclear leukocytes (pmns). in the present study we investigated the role of calcium on the tumoricidal activity of pmns induced by immunomodulators, especially tak. the calcium chelator ethylene glycol bis(beta-aminoethyl ether)-n,n,n',n'-tetraacetic acid (egta) almost completely inhibited tak-induced pmn cytotoxicity and th ... | 1986 | 3079591 |
| immunologic control of ovarian cancer. | 1988 | 3070371 | |
| serotherapy of ovarian cancer. | the development of monoclonal antibodies has permitted the identification of several ovarian-tumor-associated antigens which might serve as targets for serotherapy in vivo. with the exception of antibodies directed against growth factor receptors, unmodified monoclonal reagents must activate complement (c') components or bind effector cells to destroy tumor targets. antibody-dependent cell-mediated cytotoxicity (adcc) may be particularly important for eliminating tumor cells in vivo. a shortage ... | 1988 | 3070370 |
| [preliminary results of studies of the effect of immunostimulation combined with chemotherapy in patients with ovarian cancer]. | 1988 | 3069616 | |
| [propionibacterium acnes in the biopsied lymph nodes of sarcoidosis patients demonstrated by an immunofluorescence and immunoperoxidase staining technics]. | 1988 | 3066938 | |
| [chronic endophthalmitis caused by propionibacterium acnes in a pseudophakic patient]. | this paper reports the case of a chronic endophthalmitis with hypopion produced by propionibacterium acnes (p. a.) in a patient operated on for cataract and implanted with a posterior chamber intraocular lens. this granulomatous uveitis appeared 8 days after surgery and did not heal with a systemic corticoid-antibiotics treatment. the diagnosis was obtained by vitreous analysis. the responsibility of p. a. must be always searched in case of chronic endophthalmitis in pseudophakic patients: a spe ... | 1988 | 3062063 |
| palmoplantar pustulosis and sternocostoclavicular arthro-osteitis. | seventeen patients with shoulder pain and radiographic involvement of the sternoclavicular or sternocostal joints, or both, are described. eleven of these patients also had palmoplantar pustulosis. histological examination of the joints showed chronic and subacute inflammation, increased osteoblastic activity, and cartilage degeneration. propionibacterium acnes was cultured in tissue samples from seven of the 15 biopsied patients, a finding at variance with those of previous reports. the possibi ... | 1988 | 3058054 |
| differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following corynebacterium parvum treatment. evidence for the involvement of polymorphonuclear leukocyte proteinases. | mice bearing the b16 melanoma or treated with corynebacterium parvum develop elevated levels of plasma neutral proteinase activity. similar experiments carried out with c57bl/6-bg/bg (beige) mice, which are genetically deficient in polymorphonuclear neutrophil (pmn) proteinases, revealed that such mice develop significantly diminished elevation in plasma proteinase activity compared to c57bl/6-bg/+ mice. lysates of c. parvum elicited pmn from beige mice contained approximately 80% less neutral p ... | 1988 | 3053356 |
| differential effect of inflammatory stimuli on murine plasma c4 and factor b concentrations. | the in vivo effects of a variety of inflammatory stimuli on complement c4 and factor b plasma levels have been examined. mrl/++ (h-2k) mice were given intraperitoneal injections of lipopolysaccharide, turpentine, corynebacterium parvum pyridine extract residue or high doses of indomethacin. all of these treatments induced an increase in plasma factor b concentrations, which in the case of c. parvum was dose dependent and persisted for at least 7 days. lipopolysaccharide, turpentine and indometha ... | 1988 | 3052973 |
| diagnosis and treatment of chronic postoperative bacterial endophthalmitis. | chronic postoperative bacterial endophthalmitis has recently assumed a prominent role in differential diagnosis of inflammation following extracapsular cataract extraction with posterior chamber intraocular lens implantation. the optimal diagnostic and therapeutic approach to this entity has not yet been clearly defined. we present a case of chronic postoperative propionibacterium acnes endophthalmitis in which the diagnosis was made by anterior chamber paracentesis, and topical, periocular, and ... | 1988 | 3050671 |
| [in vitro activity of an ofloxacin-metronidazole combination against anaerobic bacteria. kinetics of the action of metronidazole against bacteroides fragilis]. | the activity of metronidazole combined with ofloxacin was investigated by the checkerboard method in liquid medium against 60 obligate anaerobes. the bacteriostatic effect of the combination was assessed by calculating the fic index. two metronidazole resistant strains of propionibacterium acnes (mic greater than 32 mg/l) were inhibited by 0.125 mg/l of this former antibiotic in presence of an ofloxacin concentration equal to half the value of the mic. on the 58 other anaerobic strains, the comb ... | 1988 | 3043345 |
| methadone vs morphine: comparison of their effect on phagocytic functions. | a comparison of the effects of methadone and morphine on phagocytic physiology was carried out in mice, using a number of tests, to estimate the risk of using methadone in maintenance protocols for opiates addicts. results indicate that methadone, like morphine, reduces (a) r.e.s. activity and (b) pmn superoxide anion production, while unlike morphine it (a) does not produce haematologic changes, (b) does not exacerbate c. albicans infections, (c) does not inhibit phagocytosis and killing by mur ... | 1987 | 3034811 |
| encephalomyocarditis (emc) virus-induced diabetes mellitus prevented by corynebacterium parvum in mice. | corynebacterium parvum prevented the development of encephalomyocarditis virus-induced diabetes in mice, when it was given 3-14 days before the virus infection. this treatment inhibited virus replication in the pancreas of the infected mice at an early stage of the infection. | 1987 | 3032672 |
| the immunological activities of components isolated from corynebacterium parvum in mice injected with polyoma tumor cells. | the inhibition of polyoma tumor in cba mice after immunization with different fractions of corynebacterium parvum was investigated. treatment with 200 micrograms of polysaccharide from culture filtrate before s.c. inoculation 2 x 10(6) of tumor cells induced antitumor effect in mice. treatment with lower doses (1 microgram or 20 micrograms) after transplantation of tumor cells was not effective. injection of lipopolysaccharide from escherichia coli abolished a positive response on inhibition of ... | 1987 | 3031518 |
| hepatic reticuloendothelial system activation in autoimmune mice: differences between (nzb x nzw)f1 and mrl-lpr/lpr strains. | 5'-nucleotidase (5'n) activity and ia expression of hepatic nonparenchymal cells (npcs) of the autoimmune (nzb x nzw)f1 and mrl-lpr/lpr and nonautoimmune c3h/fej, dba/2j, and a/j strains were assayed to determine endogenous activation of the hepatic reticuloendothelial system (res). pretreatment of the nonautoimmune strains with corynebacterium parvum resulted in decreases in fc receptor expressor and 5'n and an increase in ia expression of npcs. endogenous hepatic res activation, as measured by ... | 1987 | 3030589 |
| macrophage activation in rat models of inflammation and arthritis: determination of markers of stages of activation. | disease-associated alterations in macrophage functions were assessed by investigating the stages of activation of peritoneal macrophages obtained from adjuvant-induced arthritic rats. the stages of activation were established by defining several functional parameters in macrophages obtained from normal, sterile-irritant injected and propionibacterium acnes injected animals. peritoneal macrophages taken from arthritic rats 17 days post adjuvant injection displayed parameters characteristic of act ... | 1986 | 3026656 |
| macrophage membrane proteins: possible role in the regulation of priming for enhanced respiratory burst activity. | brief exposure of macrophages to the proteolytic enzymes papain, elastase, or trypsin primed them for enhanced production of superoxide anion (o2-) in response to stimulation by phorbol myristate acetate (pma). priming by trypsin was achieved at 0 degree c, at which temperature trypsin functions as a protease but is not internalized, supporting the concept that protease priming depends on modification of the plasma membrane. analysis of external membrane proteins after radioiodination of intact ... | 1986 | 3026655 |
| patterns of failure in patients with resected stage i and ii non-small-cell carcinoma of the lung. the ludwig lung cancer study group. | the pattern of failure was studied in 1012 patients with resected stage i or ii non-small-cell carcinoma of the lung. initial intrathoracic failure (41%) was more common than initial extrathoracic failure (34%) even though a complete resection was the intent in all patients. the most frequent sites of initial failure were the bronchial resection line (16%) and the central nervous system (cns) (15%). the site distribution of initial failure does not appear to depend on tnm stage or pattern of nod ... | 1987 | 3026260 |
| the effect of kupffer cell stimulation or depression on the development of liver metastases in the rat. | tumour cells from a squamous carcinoma (approximately 2.5 x 10(5)) were injected intraportally into a syngeneic strain of rats to produce liver metastases 14 days later. kupffer cells were stimulated by corynebacterium parvum (7 mg or 1 mg i.v.) and zymosan (10 mg intraportally). kupffer cell activity was depressed by the administration of silica, gadolinium chloride or human red cells. the animals in each group were sacrificed at 14 days, the livers removed and the number of visible surface met ... | 1986 | 3024833 |
| alveolar lymphocyte proliferation induced by propionibacterium acnes in sarcoidosis patients. | the proliferation of lymphocytes induced by propionibacterium acnes (p. acnes) was measured by the in vitro incorporation of 3h-thymidine. the mean response rate of alveolar lymphocytes obtained by bronchoalveolar lavage was 2.23 +/- 0.89 in nine untreated sarcoidosis patients, 0.85 +/- 0.17 in five sarcoidosis patients given corticosteroids and 0.78 +/- 0.29 in 11 controls. the proliferation was significantly enhanced in the untreated patients compared to both the treated patients (p less than ... | 1986 | 3024453 |
| biological activity of pityrosporum. ii. antitumor and immune stimulating effect of pityrosporum in mice. | the antitumor activity of pityrosporum (p. orbiculare, p. ovale, p. pachydermatis, and pityrosporum sp.) on ehrlich ascites carcinomas (eacs) implanted into outbred icr mice was studied. pityrosporum significantly prolonged the survival of mice, regardless of the administration mode. in the case of p. orbiculare, the maximum survival time was 32.3 days on the mean and was obtained by injection ip of 1 mg (dry weight) p. orbiculare for 7 consecutive days following inoculation of the tumor cells. ... | 1986 | 3022057 |
| the role of superoxide anion and lysosomal enzymes in anti-listerial activity of elicited peritoneal macrophages. | the in vitro effect of superoxide anion and lysosomal enzyme activity on the killing of listeria monocytogenes egd (listeria) by peritoneal macrophages (pm) was investigated. generation of superoxide anion by pm stimulated with phorbol myristate acetate (pma) was significantly increased by intraperitoneal injection of lactobacillus casei yit 9018 (lc9018) or corynebacterium parvum (cp), but not by injection of peptone. however, superoxide anion generation by lc9018-elicited pm stimulated with li ... | 1986 | 3020680 |
| relationship of success in classical immunotherapy to the relative immunorejective strength of the tumor. | six tumors of varying immunorejective strengths were used to compare the response of their isogenic hosts to standardized regimens of immunoprophylaxis and immunotherapy. the tumors were generated spontaneously or induced chemically [with 9,10-dimethyl-1,2-benzanthracene (cas: 57-97-6)], virally (with murine leukemia virus), or radiogenically (with strontium-90). the hosts were c57bl/6j or balb/cbyj mice. immunoprophylaxis and immunotherapy were performed with isogenic irradiated tumor cells, wi ... | 1986 | 3020300 |
| possible polyclonal b cell activation in mucocutaneous lymph node syndrome. | immunoserological studies on polyclonal b cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (mcls) and in age-matched healthy individuals. the incidence of anti-mite, p. acnes (kato) and eb virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. serum immunoglobulin (ig) m level and igm-anti-dinitrophenyl (dnp) antibodies, which are considered to be parameters of polyclonal b cell activation, were ... | 1986 | 3015624 |
| protection of mice against herpes simplex virus infection by a lactobacillus casei preparation (lc 9018) in combination with inactivated viral antigen. | heat-killed lactobacillus casei yit 9018 (lc 9018) cells enhanced the resistance to herpes simplex virus type 1 (hsv-1) in adult mice, but not significantly. the protection of mice against hsv-1 infection and the production of neutralizing antibodies were significantly enhanced by the administration of lc 9018 in combination with inactivated hsv-1 antigen. the optimal enhancement of resistance was seen in mice 14 days after the simultaneous administration of these substances. the resistance to h ... | 1986 | 3012292 |
| distribution of intrapleural and intravenous corynebacterium parvum in humans; 99mtc-, and 131i-labeled bacteria. | the distribution of corynebacterium parvum labeled with 131iodine or 99mtechnetium was studied in 17 patients with bronchogenic carcinoma. the labeled bacteria were given intravenously or intrapleurally and monitored by whole-body gamma tracking and samples of blood and urine. even though the rate of physical decay is quite different for 131iodine and 99mtechnetium, the tracking time of labeled bacteria was limited to 24 h after injection for both radioactive isotopes. technetium labeling was pr ... | 1986 | 3011262 |
| deficient ifn alpha production in hairy cell leukemia. | since the application of low doses of ifn-alpha is necessary to maintain remissions in hairy cell leukemia (hcl) it is of interest whether peripheral blood mononuclear cells (mnc) of hcl patients can be induced in vitro to produce ifn-alpha. 9 patients suffering from advanced hcl were included in the study. the diagnoses were confirmed by characteristic findings in peripheral blood and bone marrow biopsies. for ifn treatment we initially used natural ifn-alpha (bioferon) and switched later to re ... | 1986 | 3006840 |
| protease production by microorganisms associated with reproductive tract infection. | factors influencing pathogenicity of various microbes found in the female lower genital tract remain incompletely understood. protease production by cervico/vaginal microorganisms may alter or inactivate a variety of proteins important in host defense and structural-functional integrity including collagen-containing chorioamniotic membranes and uterine cervix. host tissues may be made more susceptible to other organisms' virulence factors by protease-producing members of genital tract local flor ... | 1986 | 3004213 |
| oxygen-derived free radicals promote hepatic injury in the rat. | we have investigated the possible protective effect of superoxide dismutase and allopurinol in a rat model of mild and severe hepatic necrosis produced by corynebacterium parvum with or without endotoxin. histology showed a sinusoidal mononuclear cell infiltrate with multiple granulomata but variable degrees of hepatic necrosis. in the severe hepatic injury model there was a reduction in mortality, associated with a decrease in histologic and biochemical evidence of hepatic necrosis, after treat ... | 1985 | 2995189 |
| susceptibility of propionibacterium acnes to killing and degradation by human neutrophils and monocytes in vitro. | propionibacterium acnes, the target of inflammation in acne, was tested for its sensitivity to the bactericidal and degradative functions of human polymorphonuclear leukocytes (pmn), monocytes, and their fractions. p. acnes strains were not killed by pmn under any conditions and were variably killed by monocytes in the presence of serum from acne patients. control strains of staphylococcus aureus and micrococcus lysodeicticus were susceptible to both pmn and monocyte killing. p. acnes strains we ... | 1985 | 2989178 |
| activation of mouse macrophages causes no change in expression and function of phorbol diesters' receptors, but is accompanied by alterations in the activity and kinetic parameters of nadph oxidase. | mouse peritoneal macrophages activated in vivo by the injection of corynebacterium parvum release larger amounts of superoxide anion (o2-) than macrophages from control mice when stimulated with phorbol myristate acetate (pma). the biochemical bases for this enhanced response of activated macrophages have been investigated by studying the expression and function of receptors for the stimulant, and the activity of the enzyme nadph oxidase which is responsible for the production of o2- in leucocyt ... | 1985 | 2981767 |
| an ultrastructural examination of murine alveolar macrophages following intranasal administration of propionibacterium acnes. | light and electron microscopic analysis of murine lungs or isolated pulmonary cells was performed three days after intranasal administration of the bacterial immunostimulant, propionibacterium acnes (p. acnes). our observations indicated that pulmonary alveolar and airway macrophages (pams) were the only cells with p. acnes bacilli in their cytoplasm. bacilli were not observed in pulmonary interstitial macrophages, granulocytes, lymphocytes or pulmonary parenchymal cells such as type i and type ... | 1987 | 2980723 |
| granulocyte activating factor released from propionibacterium acnes. a possible mediator of inflammation in acne vulgaris. | incubation of propionibacterium acnes but not of propionibacterium granulosum or propionibacterium avidum (for 30 min at 37 degrees c in physiological saline) released a soluble factor that produced enhanced chemiluminescence response of human granulocytes as well as increased chemotactic motility of these cells. sephadex g-25 filtration of the granulocyte activating factor (gaf) revealed its low molecular weight and apparent peptide character. thus, gaf may be a stimulus for inflammation in acn ... | 1988 | 2975904 |
| acne vulgaris and malignancy. | seventy patients with lymphomas and leukaemias were interviewed. details of past acne vulgaris were recorded and a clinical examination performed. a history of acne was less common in the patients than in matched controls. in addition, fewer patients had received treatment prescribed by a medical practitioner for their acne than had the controls. examination revealed fewer patients with acne. these results suggest a reduced incidence of acne or its more severe forms in patients who have develope ... | 1988 | 2974720 |
| the antibiotic susceptibility of propionibacterium acnes: a 15-year bacteriological study and retrospective evaluation. | 1988 | 2971698 | |
| [propionibacterium acnes septicemia in a mycosis fungoides]. | 1988 | 2970819 | |
| the microbial colonization of inflamed acne vulgaris lesions. | seventy one papules in the early stages of inflammatory development were isolated from acne vulgaris affected skin and their content of micro-organisms characterized. the progress of lesions prior to excision was monitored by tracing an area of the upper back onto a transparent acetate sheet. this template was used the next day, and in some cases after 3 days, to identify inflamed lesions of less than 1 day and 2-3 days duration. these were biopsied, and pilosebaceous units isolated by micro-dis ... | 1988 | 2964856 |
| azelaic acid. | this review is an update on the literature accumulated over the past 10 years following the original observation that azelaic acid, a naturally occurring and nontoxic c9 dicarboxylic acid, possesses significant biologic properties and a potential as a therapeutic agent. these studies have shown that azelaic acid is a reversible inhibitor of tyrosinase and other oxidoreductases in vitro and that it inhibits mitochondrial respiration. it can also inhibit anaerobic glycolysis. both in vitro and in ... | 1987 | 2963038 |
| in vitro activity of vancomycin and teicoplanin against anaerobic bacteria. | the in vitro activity of vancomycin and teicoplanin, a new glycopeptide antimicrobial, was determined against a total of 286 anaerobic bacteria including bacteroides fragilis group (100), b. melaninogenicus (21), b. bivius (16), fusobacterium spp. (15), peptococcus spp. (20), peptostreptococcus spp. (21), clostridium perfringens (23), c. difficile (41) and propionibacterium acnes (29). minimum inhibitory concentrations (mic) were determined using an antimicrobial incorporation technique in wilki ... | 1987 | 2962846 |
| [occurrence and levels of serum antibodies against propionibacterium antigens in persons of various ages]. | 1987 | 2959828 | |
| the production of inflammatory compounds by propionibacterium acnes and other skin organisms. | culture supernatants from four species of skin microorganisms (p. acnes, p. avidum, p. granulosum and s. epidermidis) were assayed for smooth muscle contracting substances which are indicative of inflammatory activity. at least three types of smooth muscle contracting substances were detected. these were: first, a substance active on a rat fundic strip preparation and antagonized by n,n-dmt. activity was enhanced when cultures were grown in the presence of tryptophan. this substance was probably ... | 1987 | 2958076 |
| [pathomechanism, bacteriology and treatment of acne changes]. | 1987 | 2957292 | |
| antibodies to p. acnes and p. acnes exocellular enzymes in the normal population at various ages and in patients with acne vulgaris. | total serum igm and igg agglutinins to p. acnes and neutralizing antibodies to p. acnes lipase, hyaluronate lyase and acid phosphatase were measured in normal individuals of different age groups. agglutinins to p. acnes were detected in infants at 4 months of age and were present at a high level throughout life. a switch from predominantly igm agglutinins in children, to igg agglutinins in adults, occurred during adolescence. anti-p. acnes lipase antibodies were present in 20% of teenagers and 1 ... | 1987 | 2956986 |
| no photoinactivation of propionibacterium acnes with soft laser treatment. | 1987 | 2956136 | |
| uptake of protoporphyrin and violet light photodestruction of propionibacterium acnes. | the uptake of protoporphyrin ix by propionibacterium acnes in suspension has been studied by fluorescence spectroscopy. protoporphyrin, after it was injected into a cell suspension, was firstly bound to receptors on the cell surface and in this state protoporphyrin was non-fluorescent. subsequently, probably as a result of lateral diffusion in the cell wall, these protoporphyrin-receptor complexes formed dimers. the final step in the overall uptake process of protoporphyrin by the cells from the ... | 1987 | 2953128 |
| [antibiotic susceptibility of propionibacterium acnes; changes in the last 15 years at the department of dermatology, kansai medical university]. | 1986 | 2951538 | |
| antigen-specific suppression of the in vitro cytotoxic response by a soluble factor produced by corynebacterium parvum-induced allospecific suppressor cells. | the adjuvant corynebacterium parvum, when administered intravenously during an ongoing alloimmunization, induces alloantigen-specific splenic suppressor cells which inhibit primary and secondary in vitro sensitizations. we have previously shown that these cells produce a soluble suppressor factor in culture. we now further characterize this factor and its mechanism of action. release of this suppressive factor is dependent upon specific restimulation of the splenic suppressor cell with the sensi ... | 1987 | 2949854 |
| in vitro and in vivo evaluation of a-56268 (te-031), a new macrolide. | the in vitro and in vivo antibacterial activity of a-56268 (te-031), the 6-o-methyl derivative of erythromycin, was compared with those of erythromycin and other reference drugs. a-56268 had the same spectrum of antibacterial activity as erythromycin. a-56268 was generally 1 log2 dilution more potent or equal to erythromycin against all organisms except haemophilus influenzae and propionibacterium acnes, for which a-56268 was 1 log2 dilution and 3 log2 dilutions, respectively, less potent. the m ... | 1986 | 2949695 |
| comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. | a 2.5% formulation of benzoyl peroxide was compared with its vehicle, and with a 5% and a 10% proprietary benzoyl peroxide gel preparation in three double-blind studies involving 153 patients with mild to moderately severe acne vulgaris. the 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules). desquamation, erythema, and symptoms of burning with the 2.5% gel wer ... | 1986 | 2948929 |
| photodestruction of endogenous porphyrins in relation to cellular inactivation of propionibacterium acnes. | during growth of propionibacterium acnes on eagles medium protoporphyrin was accumulated inside the cells and coproporphyrin, both as a free base as metalcontaining, outside the cells. the photochemical processes in the endogenous porphyrins were studied by fluorescence spectroscopy during continuous irradiation of propionibacterium acnes in suspension. the irradiation caused initially an increase in the content of protoporphyrin in the cells in comparison to that which had been accumulated duri ... | 1986 | 2948330 |
| the in vitro antimicrobial effect of azelaic acid. | various strains of cutaneous micro-organisms were tested in vitro for their survival rates in 0.5 mol/l (8.4% w/v) azelaic acid solution. all bacterial strains exhibited large reductions in viability (at least 40-fold) over a 24 h test period, but little response was noted with pityrosporum ovale. the bactericidal effect of azelaic acid was reduced considerably in the presence of nutrients. minimum inhibitory concentrations (mics) and minimum bactericidal (or fungicidal) concentrations (mbcs) we ... | 1986 | 2947607 |
| rational therapy for acne vulgaris: an update on topical treatment. | acne vulgaris is a disorder of sebaceous follicles that usually begins at the time of the sharp increase in androgen production that occurs in adolescence. this disease is most prevalent among teenagers, but it does occur in patients in their twenties and thirties. three major areas of pathophysiology have been identified in acne: hyperkeratinization and obstruction of sebaceous follicles, resulting from abnormal desquamation of follicular epithelium; an androgen-stimulated increase in the produ ... | 1986 | 2945846 |
| qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. | quantitative cultures in 40 patients treated with systemic isotretinoin demonstrated a significant reduction in the anaerobic diphtheroid, propionibacterium acnes within one month of therapy and a continued suppression during 5 months of treatment. this reduction persisted after discontinuation of isotretinoin therapy despite a return of sebum excretion to pretreatment levels. surface aerobic bacteria showed a significant reduction in the total number of organisms and significant qualitative cha ... | 1986 | 2943823 |
| [treatment of skin changes in acne using propionibacterium antigens in the form of an oral vaccine]. | 1986 | 2942740 | |
| acne vulgaris in childhood. pathogenesis and management. | acne vulgaris is a common skin disorder. although it is most prevalent in the second decade of life, its beginnings are heralded by increased activity of the sebaceous glands and faulty follicular keratinization, which are already evident in mid to late childhood. the subsequent and increasing proliferation of the follicular anaerobic diphtheroid microflora contribute further as an important pathogenic factor in the generation of inflammatory lesions. treatments of acne, therefore, are aimed at ... | 1986 | 2941198 |
| reaction of the thymus and the bursa of fabricius in chickens inoculated with corynebacterium parvum. | 1985 | 2940837 | |
| splenocytes from tumor-bearing corynebacterium parvum treated mice maintain interleukin-2 and -3 activity. | systemic and local administration of the bacterium corynebacterium parvum (more accurately known as propionibacterium acnes) is reported to exert antitumor action via activated macrophages or short-lived cytotoxic t lymphocytes (ctl), respectively. this study examined the effect of c. parvum treatment on resulting in vitro interleukin levels, which are components in the sequence of events leading to the development of effective ctl. c. parvum administration prevented palpable fibrosarcoma develo ... | 1986 | 2939948 |
| acne vulgaris. the past. the present and the future. | 1985 | 2939675 | |
| [proof of the effectiveness of a clotrimazole cream paste in acne vulgaris]. | the efficacy of clotrimazol cream paste containing a penetration enhancer in the treatment of acne vulgaris was objectified by investigating the sebum composition. following treatment over three and six weeks, the ratio of triglyceride to free fatty acid significantly increased, which indicated an effective reduction of the lipase activity of propionibacterium acnes within the sebaceous follicle. | 1986 | 2938349 |
| tumor-specific suppressor t-cells which inhibit the in vitro generation of cytolytic t-cells from immune and early tumor-bearing host spleens. | spleen cells from dba/2 mice, after immunization with syngeneic p815 mastocytoma cells and corynebacterium parvum, respond to p815 in vitro with a brisk, secondary-type generation of cytotoxic cells. this cytotoxicity is mediated by antigen-specific t-lymphocytes and correlates with resistance to in vivo challenge. this model confirms the observations of previous investigators made in semisyngeneic hosts using an in vivo transfer model. spleen cells from "early" tumor-bearing hosts (tbhs), 7-12 ... | 1986 | 2936451 |
| suppression and abrogation of suppression of induced nonspecific cytotoxicity against tumor cells. | fresh spleen cells obtained from normal mice of various strains including athymic mice and nk-less beige mice were found to suppress in a h-2-nonrestricted manner nonspecific cytotoxic activity of in vitro-cultured normal mouse spleen cells or that of nonadherent peritoneal exudate cells from mice treated with propionibacterium acnes. natural killer-insensitive mm2 ascites tumor cells were used as the target of assay of the cytotoxicity. the suppressive activity of fresh spleen cells was not aff ... | 1985 | 2935654 |
| suppression of murine nk activity induced by corynebacterium parvum: further characterization and abrogation of suppressor cells. | formalin-killed corynebacterium parvum (cp), given at a dose of 0.4-0.7 mg/mouse iv or ip, induced suppressor cells for nk activity in b6c3f1 mice. the suppressor cells belong to at least two different populations, plastic adherent and nonadherent, and were not depleted by antibodies specific for thy-1.2, iak, or nk-1.2 surface markers. administration of p-i:c, an interferon-inducer, to animals 18 h before the assay did not affect the suppressor activity. hypotonic shock treatment of splenocytes ... | 1986 | 2935247 |
| the effect of bone marrow depletion on prostaglandin e-producing suppressor macrophages in mouse spleen. | the i.p. injection of corynebacterium parvum (cp) into cba/j mice effected increases in macrophage colony-forming cells (m-cfc) when spleen cells were cultured with l cell culture filtrate as a source of colony-stimulating factor. significant increases in phagocytic macrophages (m phi) with fc receptors for igg2a and igg2b immune complexes were additionally noted among the spleen cells in these mice. these m phi effectively inhibited con a-induced lymphocyte proliferation, probably reflecting a ... | 1985 | 2933455 |
| acne vulgaris. treatments and their rationale. | 1985 | 2932686 | |
| reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. | germfree (gf) f344 rats developed severe adjuvant-induced arthritis with a 100% incidence after a single intradermal injection of heat-killed mycobacterium bovis (bcg). specific pathogene-free (spf) rats developed less severe arthritis with a lower incidence. the rats colonized with escherichia coli or bacteroides developed mild disease comparable to that in spf rats. the rats colonized with bifidobacterium, propionibacterium acnes, lactobacillus casei, l. fermentum, l. murini, and l. acidophilu ... | 1985 | 2931580 |
| characteristics of toxic shock syndrome toxin 1-induced lectin-like activity and inhibitor(s) in rabbit serum. | in adult rabbits intravenously injected with toxic shock syndrome toxin 1 (tsst-1) or staphylococcal enterotoxin b, serum lectin-like activity (detectable by cation-dependent agglutination of bacteria) developed. this activity was sensitive to heat, trypsin, and formaldehyde but resistant to neuraminidase or galactose oxidase. formaldehyde-fixed propionibacterium acnes or escherichia coli cells reactive with plant lectins provided sensitive targets for titration of serum agglutination activity t ... | 1989 | 2928648 |
| endophthalmitis due to propionibacterium acnes sequestered between iol optic and posterior capsule. | a 68-year-old woman had delayed onset, persistent uveitis following routine extracapsular cataract extraction with posterior chamber intraocular lens implantation. the patient initially responded to topical steroids, but developed a whitish capsular plaque through to represent possible propionibacterium acnes endophthalmitis. a vitrectomy and capsular biopsy yielded cultures positive for p. acnes only after nine days. the intraocular lens was left in place. light and electron microscopy revealed ... | 1989 | 2927902 |
| peptostreptococcus magnus does not cause hematogenous infections in experimental arthroplasties. | rabbits with cemented endoprostheses in the knee joints were given 1-ml intravenous injections of suspensions containing peptostreptococcus magnus (3 x 10(8) colony-forming units/ml) on three consecutive days seven weeks postoperatively. the animals were killed after another seven weeks. the bacterial challenge did not result in infection. this is in contrast to a previous study using the same experimental system with another anaerobic bacterial species, propionibacterium acnes, which caused inf ... | 1989 | 2924473 |
| modulation of hematoporphyrin derivative-sensitized phototherapy with corynebacterium parvum in murine transitional cell carcinoma. | the interaction of photodynamic therapy (pdt) with hematoporphyrin derivative (hpd) and immunotherapy with corynebacterium parvum (cp) was studied in a murine transitional cell carcinoma (mbt-2) model. c3h/he mice were transplanted subcutaneously in the hind limb with 2.5 x 10(5) tumor cells. one day after transplantation, mice were randomized into groups to receive saline (control), pdt, cp 25 micrograms, cp 250 micrograms, cp 25 micrograms + pdt, and cp 250 micrograms + pdt. pdt was administer ... | 1989 | 2919485 |
| ischaemic mouse thigh model for evaluation of pathogenicity of non-clostridial anaerobes. | a mouse thigh model has been devised in which the growing culture of non-clostridial anaerobe in the ischaemic tissue produces inflammatory swelling and death. the swelling of the right thigh served as an index of pathogenicity of the test strain in comparison to the negatively reacting left thigh which received injection of the control strain of bifidobacterium infantis. actinomyces naeslundii exceptionally caused death in all animals within 24 h. mortality and thigh swelling were pronounced (g ... | 1989 | 2914729 |
| mechanism of decline of natural killer cell activity in corynebacterium parvum-treated mice: inhibition by erythroblasts and thy 1.2+ lymphocytes. | injection of (c57bl/6 x dba/2)f1 mice with corynebacterium parvum (cp), iv, resulted in a depression of splenic natural killer (nk) cell activity 7-17 days after treatment. this decline in reactivity was accompanied by an increase in splenic tumor-binding cells and a decrease in cytotoxic tumor-binding cells as evaluated in a single-cell assay. morphologic analysis indicated that the increased tumor-binding cells following cp injection were due to erythroblasts binding to yac-1 tumor cells. with ... | 1987 | 2887687 |
| protection of mice against intestinal amoebiasis with bcg, corynebacterium parvum and listeria monocytogenes. | treatment with corynebacterium parvum or bcg, or infection with live listeria monocytogenes was found to protect mice against subsequent infection with entamoeba histolytica. complete protection was obtained in mice treated with 10(7) (colony forming units) of bcg but not with 10(5). partial protection was achieved with 10(6) of bcg. these data provide evidence that non-specific immunity plays an important role in the host defense against amoebic infection. | 1986 | 2880331 |
| intrapleural and intravenous corynebacterium parvum in patients with resected stage i and ii non-small cell carcinoma of the lung. the ludwig lung cancer study group. | a prospective randomized trial compared the administration of intrapleural plus intravenous corynebacterium parvum (c. parvum) versus placebo in patients with resected stage i and stage ii non-small cell bronchogenic carcinoma. treatment consisted of 7 mg c. parvum injected into the pleural space and 7 mg c. parvum intravenously once between days 6 and 12 postoperatively and 7 mg intravenously every 3rd month during the 1st year. intrapleural administration of 35 cc of saline served as the place ... | 1986 | 2876772 |
| comparative in-vitro activity of sch 34343 and other antimicrobial agents against anaerobic bacteria. | the activity of sch 34343 was determined against 575 strains of anaerobic bacteria by an agar-dilution method. its activity was compared with that of benzylpenicillin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole, chloramphenicol, vancomycin, fusidic acid and bacitracin. sch 34343 and imipenem were the most active agents tested. based on these results, sch 34343 appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigations. | 1985 | 2863246 |
| the involvement of dendritic cells in the handling of the immune stimulant c. parvum. a morphological investigation using immunoperoxidase techniques. | in earlier experiments we showed that locally administered corynebacterium parvum (c. parvum) stimulated the t-cell system and had a beneficial effect on the recurrence rate of surgically resected cancers of the uterine cervix. in this paper we report the use of an immunoperoxidase technique to trace c. parvum antigen in the draining lymph nodes. in a guinea pig model the popliteal lymph node was studied after the injection of 70 micrograms of c. parvum in the hind footpad. at 6 h, intact bacter ... | 1985 | 2861687 |
| adverse effect of intrapleural corynebacterium parvum as adjuvant therapy in resected stage i and ii non-small cell carcinoma of the lung. ludwig lung cancer study group. | intrapleural corynebacterium parvum 7 mg or placebo was administered postoperatively as adjuvant therapy to patients with resected stage i and ii non-small cell lung cancer in a prospective, randomized, multicenter trial. a total of 475 patients were entered into this study between july, 1977, and february, 1979. of this group, 405 can be evaluated, with an average follow-up time of 4.6 years. more side effects, especially fever and chest pain, were observed in patients receiving corynebacterium ... | 1985 | 2860271 |
| bacterial products as immunomodulating agents. | 1985 | 2858453 | |
| influence of immunomodulatory agents on bovine humoral and cellular immune responses to parenteral inoculation with bovine rotavirus vaccines. | sodium diethyldithiocarbamate (dtc), mycobacterium cell wall extract (mcwe, regressin), killed corynebacterium parvum (c. parvum, immunoregulin) and muramyldipeptide (mdp) were each combined with purified, live bovine rotavirus and inoculated into 3 month-old holstein-friesian calves in order to examine their ability to potentiate specific humoral and cellular immune responses. the vaccinated calves were boosted twice at 3 and 6 weeks after initial vaccine inoculation. the rotavirus was administ ... | 1988 | 2847397 |
| effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. | reactive oxygen intermediates released by activated hepatic macrophages have been implicated in the pathogenesis of a rat model of liver injury induced by sequential administration of corynebacterium parvum and endotoxin. in this model, c. parvum causes extensive infiltration of the liver with activated macrophages, but severe liver injury occurs only after subsequent exposure to endotoxin. we have therefore investigated the effects of endotoxin on the release of reactive oxygen intermediates by ... | 1988 | 2846404 |
| effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2. | to define the effect of heterogeneity of murine peritoneal macrophages (m phi) on intrinsic resistance to herpes simplex virus (hsv) infection, several m phi populations were characterized for their response to infection with hsv type 1 (hsv-1) and hsv-2. steady-state resident m phi (res m phi) were compared in parallel with m phi activated with corynebacterium parvum (now designated propionibacterium acnes) (cp m phi) and thioglycollate-elicited inflammatory m phi (tg m phi). res m phi were com ... | 1988 | 2841412 |
| bone marrow derived macrophages have polyamine and ectoenzyme phenotypes distinct from resident macrophages. | several prototype macrophage (mo) populations were compared for differences in ectoenzyme phenotype and polyamine content. resident peritoneal mo and corynebacterium parvum (cp)-activated peritoneal mo expressed unique ectoenzyme phenotypes, while bone marrow derived mo (bmdmo), obtained from stem cells after 7 days in culture with colony stimulating factor, and thioglycollate (tg)-elicited peritoneal mo exhibited a similar ectoenzyme phenotype. all of the mo populations, however, differed in po ... | 1988 | 2835568 |
| two-dimensional gel electrophoresis of ribosomal proteins from propionibacterium acnes and granulosum. | ribosomal proteins (r-proteins) from a type i strain (atcc 11827) and a type ii strain (atcc 11828) of propionibacterium acnes (p. acnes) and from a propionibacterium granulosum (p. granulosum) strain (atcc 11829-2) were analyzed using two-dimensional polyacrylamide gel electrophoresis (two-dimensional page), for the purpose of genetical analysis of the p. acnes type i and type ii strains and the p. granulosum strain. among the fifty r-proteins in all, almost all of the proteins were electrophor ... | 1989 | 2818796 |
| infectious arthritis caused by propionibacterium acnes: a report of two cases. | propionibacterium acnes, a micro-organism with low pathogenicity, rarely causes arthritis in a joint without a prosthesis. this report deals with two cases of p acnes infectious arthritis probably caused by direct penetration of the micro-organism into the joint space during arthrocentesis, despite the use of strict disinfection procedures. p acnes isolated from synovial fluid cannot be dismissed as a bothersome contaminant without due consideration of the clinical status of the individual patie ... | 1989 | 2818021 |
| [spondylitis of the cervical spine caused by non-sporogenic anaerobes]. | 1989 | 2811118 | |
| [the response of alveolar lymphocytes induced by propionibacterium acnes in pulmonary sarcoidosis: correlation with clinical studies, pulmonary function studies and bronchoalveolar lavage]. | current concepts of the pathogenesis of sarcoidosis suggest that the alveolitis in this disorder is related to increased numbers of helper t-cells within the lungs. however, the mechanism of this accumulation of lymphocytes is not known. we have reported that proliferation of alveolar lymphocytes induced by p. acnes is increased in patients with active sarcoidosis. to determine whether the response of alveolar lymphocytes would be useful in staging the activity of pulmonary sarcoidosis, we studi ... | 1989 | 2810973 |
| an experimentally-induced acute hepatic failure model in various strains of mice. | when balb/cajc1 mice are intravenously injected with heat-killed propionibacterium acnes (p. acnes) followed by an intravenous injection of lipopolysaccharide (lps) 7 days later, massive necrosis is induced in the liver tissue and most of the mice die within 24 hours of lps injection. using this experimental model, acute hepatic failure was induced in various strains of mice and the difference in the response was studied. as a result, as in balb/cajc1 mice, acute hepatic failure was also induced ... | 1989 | 2806831 |
| propionibacterium acnes isolated from explanted intraocular lens in pseudophakic bullous keratopathy. | propionibacterium acnes is an anaerobic bacterium that has been reported to produce ocular infection or inflammation following surgery or penetrating trauma. it has been well documented as an etiologic agent associated with infections of prosthetic implants, including intraocular lenses (iols). p. acnes is part of the natural flora of the external eye and has biological properties that may promote, heighten, or prolong an inflammatory response. it not only resists in vitro degradation by reticul ... | 1989 | 2805713 |
| intralenticular abscess. | intralenticular abscess is an uncommon complication of surgery or trauma. a case of intralenticular abscess following penetrating trauma is presented. in this case, the offending organism was identified as propionibacterium acnes. this organism is considered to be a cause of slowly progressing endophthalmitis and has been implicated as a cause of the so-called toxic lens syndrome. | 1989 | 2803777 |
| toxicity of il-2 and corynebacterium parvum following direct intracranial injection. | the toxicity of il-2 and/or c. parvum when injected directly into the mouse brain was examined by survival and histopathology using different numbers of injections, different doses of il-2, different solvents for the il-2, and different doses and routes of administration of c. parvum. two injections was found significantly to increase mortality (19%) over a single injection (4%). mortality from two injections of 30,000 u (23%) or 60,000 u (20%) was higher than from two injections of 15,000 u (12 ... | 1989 | 2795120 |
| [comparison of the effectiveness and adverse effects of a corynebacterium parvum vaccine made in czechoslovakia with coparvax, a british preparation made by wellcome, in the treatment of malignant pleural effusions]. | malignant pleural effusion complicates various malignant diseases, most frequently lung and breast cancer. a group of 20 patients with this complication were treated with the czechoslovak vaccine corynebacterium parvum and the english preparation coparvax, and their effects and side-effects were compared. within 4 weeks following the application, 7 patients died. in 9 surviving patients, the exudate ceased to be replenished and in 4 persons, after intrapleural application of the preparation, it ... | 1989 | 2790915 |
| management options for propionibacterium acnes endophthalmitis. | the authors reviewed the management of nine culture-proven cases of propionibacterium acnes endophthalmitis which presented at an average of 4 months after extracapsular cataract extraction (ecce) and posterior chamber intraocular lens (pc iol) implantation. the initial signs included a white intracapsular plaque (9/9), vitritis (9/9), granulomatous uveitis (4/9), nongranulomatous uveitis (5/9), hypopyon (4/9), beaded fibrin strands in the anterior chamber (3/9), and diffuse intraretinal hemorrh ... | 1989 | 2788852 |
| [infections by anaerobes in children: frequency of isolation and antimicrobial resistance]. | we studied the frequency of isolation and antimicrobial susceptibility of strict anaerobic bacteria isolated in a paediatric hospital. a total of 1,753 samples from purulent material and hemocultures were processed. one hundred and thirty strains were isolated from 95 children: 44 from 48 cases of peritonitis (91.7%), 2 from 8 brain abscesses (25%), 23 from 124 soft tissue abscesses (18.5%), 4 from 64 empyemas or lung abscesses (6.3%) and 22 from 1,509 hemocultures (1.5%). mixed infection (anaer ... | 1989 | 2788434 |
| [interleukin-2 production and receptor expression of alveolar lymphocytes stimulated by propionibacterium acnes in sarcoidosis]. | we previously reported that alveolar lymphocytes in patients with active sarcoidosis are sensitized to propionibacterium acnes (p. acnes) which may play a significant role in the induction of alveolitis in these patients. however, the mechanism of lymphocyte activation is not fully understood. in this study, we further investigated the production of interleukin-2 (il-2), and the responsiveness to il-2 of alveolar lymphocytes obtained from sarcoidosis patients and stimulated by p. acnes in vitro. ... | 1989 | 2787441 |
| analysis of the proinflammatory property of epidermal cyst contents: chemotactic c5a anaphylatoxin generation. | we investigated in vitro the contents of epidermal cysts for complement activation and found that they activated complement mainly through the alternative pathway. chemotactic c5a anaphylatoxin produced by the cyst contents after contact with serum most likely plays a significant role in the initiation and aggravation of inflammation in ruptured epidermal cysts. our additional study disclosed that components of three representative follicular resident microorganisms (pityrosporum ovale, propioni ... | 1989 | 2786384 |
| hematologic interactions of endotoxin, tumor necrosis factor alpha (tnf alpha), interleukin 1, and adrenal hormones and the hematologic effects of tnf alpha in corynebacterium parvum-primed rats. | endotoxin reduces the release among other cytokines of tumor necrosis factor (tnf) and interleukin 1 (il-1) and causes peripheral lymphopenia and a dose-response-dependent initial neutropenia followed by a monophasic neutrophilia. tnf alone induces lymphopenia and an initial neutropenia followed by a biphasic neutrophilia. il-1 alone induces lymphopenia and a monophasic neutrophilia. tnf-plus-il-1 caused a greater lymphopenia than either monokine alone, suggesting that both monokines contribute ... | 1989 | 2786048 |
| diphtheroids as ocular pathogens. | unlike corynebacterium diphtheriae and propionibacterium acnes, the pleomorphic gram-positive rods known as diphtheroids are generally regarded as nonpathogenic contaminants of the human external eye. we reviewed five years of microbiology records at wills eye hospital and studied a series of eight cases of apparently infectious keratitis associated with heavy growth of diphtheroids on cultures of ulcer scrapings. all of these cases included indolent ulcers that occurred almost exclusively in el ... | 1989 | 2774033 |
| [changes in production of platelet activating factor by adherent hepatocytes of mice with experimental liver failure]. | it is thought that the platelet activating factor (paf) enhances the immune response and inflammatory reaction. we studied the production of paf from liver adherent cells. as a result, liver adherent cells produced paf, when they were stimulated with calcium ionophore. in addition, when mice were treated with heat-killed propionibacterium acnes and the mononuclear cells were infiltrated into the liver, a significantly larger amount of paf was produced compared to normal mice. | 1989 | 2770018 |
| non-specific resistance to babesia divergens in the mongolian gerbil (meriones unguiculatus). | inoculation of mature gerbils with bcg gave protection to subsequent infection with b. divergens when inoculated by the intracardiac and intraperitoneal routes, the latter showing a dose dependent relationship. bcg vaccination was most effective in immature gerbils (less than 4 weeks old), which are innately resistant to b. divergens. vaccination of gerbils with killed propionesbacterium acne and zymosan a failed to elicit a protective response, which contrasts conspicuously with rodent babesia ... | 1989 | 2759766 |
| serotonin and tryptamine metabolism in the acute hepatic failure model: changes in tryptophan and its metabolites in the liver, brain and kidney. | when heat-killed propionibacterium acnes, a gram-positive anaerobe, is intravenously injected into mice followed by an intravenous injection of gram-negative lipopolysaccharide (lps) 7 days later, most of the mice die of massive hepatic cell necrosis within 24 hours of lps injection. using this experimental model, acute hepatic failure was induced in mice, and the tryptophan metabolism in the liver, brain and kidney was studied. as a result, the tryptophan level was remarkably high in all three ... | 1989 | 2748146 |