Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [erythrocyte enzymes at different stages of plasmodium berghei schizogony]. | 1981 | 7033753 | |
| [synthesis of benzo(g)quinoline derivatives. xv. di[benzo(g)-quinolylpiperazinyl]alkanes possessing antimalarial activity]. | 1981 | 7033752 | |
| leishmania donovani, plasmodium berghei, trypanosoma rhodesiense: antiprotozoal effects of some amidine types. | 1981 | 7032963 | |
| sustained-release implants in the chemotherapy of experimental rodent malaria ii. the effects of sulphadiazine, pyrimethamine and cycloguanil in biodegradable polymer matrices. | 1981 | 7032431 | |
| sustained-release implants in the chemotherapy of experimental rodent malaria i. a comparison of the effects of some antimalarials in polydimethylsiloxane matrices. | 1981 | 7032430 | |
| studies on the infectivity of plasmodium berghei sporozoites in experimental hosts. | 1981 | 7032427 | |
| synthesis of some novel amodiaquine analogues as potential antimalarial and antifilarial compounds. | ten amodiaquine analogues, which are hybridized molecules of amodiaquine and diethylcarbamazine, were designed and synthesized. six analogues, all bearing a basic tertiary amino function at their side chain, were active against plasmodium berghei in mice and inhibited the mobility of adult worms and microfilariae of breinlia booliati in vitro. they were inactive against litomosoides carinii in mastomys natalensis. the most active antimalarial compound, 7-chloro-4-[alpha-[[n-(4-methyl-1-piperazin ... | 1981 | 7031248 |
| atypical reticulocytes in rats with malaria as a possible consequence of the pitting function of the spleen. | 1981 | 7030237 | |
| malarial antibodies and parasitaemias in immunosuppressed mice. | 1981 | 7028884 | |
| treatment of rodent malaria with levamisole. | 1981 | 7028880 | |
| immunosuppression in murine malaria: a soluble immunosuppressive factor derived from plasmodium berghei-infected blood. | mice infected with plasmodium berghei have a depressed immune response to a variety of antigens. we report the extraction, purification, and characterization of a soluble immunosuppressive substance derived from p. berghei-infected mouse blood. a crude extract, prepared by solubilization of infected erythrocytes in a parr cell disruption bomb, reduced the anti-dnp pfc response of mice injected with the extract 1 day before immunization. purification of the immunosuppressant was accomplished by p ... | 1981 | 7028864 |
| [oxidative and antioxidative system of the blood in mechanisms of erythrocyte protection and damage upon invasion by plasmodium berghei]. | in the course of experimental infection with pl. berghei, the mice demonstrated an abrupt lowering in the activity of blood enzymes (superoxide dismutase and glutathione peroxidase) and a rise in the concentration of the lipid peroxidation product (malonic dialdehyde) with the growth of parasitemia. the evidence obtained are discussed in the light of the defence and injury blood mechanisms of red cell membranes. | 1981 | 7028174 |
| hemin lyses malaria parasites. | malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin ix chloride (hemin) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin. this effect of hemin may explain the protection against malaria provided by thalassemia and other conditions causing intracellular denaturation of hemoglobin. the toxicity of the chloroquine-hemin complex may explain the selective antimalarial action o ... | 1981 | 7027441 |
| chloroquine resistant p. berghei: association with variation in plasmodial protease activity. | 1981 | 7027269 | |
| biosynthesis of pb44, the protective antigen of sporozoites of plasmodium berghei. | in a previous paper (2) we identified a protective antigen (pb44) of the surface membrane of sporozoites of plasmodium berghei by means of a monoclonal antibody. immunoprecipitation of extracts of mature salivary gland sporozoites, metabolically labeled with l[35s]methionine using the same monoclonal antibody, revealed three specific polypeptides: *pb44, *pb52, and *pb54. metabolically labeled *pb44 is probably identical to the protective antigen previously identified by surface labeling. both p ... | 1981 | 7026723 |
| blood schizontocidal activity of antibiotics against plasmodium berghei sensitive as well as resistant to chloroquine, pyrimethamine and primaquine. | 1981 | 7026431 | |
| [complex morphologic modifications observed on the surface of red blood cells parasitized by plasmodium berghei (1)]. | 1981 | 7025979 | |
| adoptive transfer of immunity to plasmodium berghei after busulfan and cyclophosphamide treatment of recipient mice. | balb/c mice injected with p. berghei die about 21 days after infection. successful cell transfer in mice was made possible by the pretreatment of the recipient with a combination of busulfan and cyclophosphamide. cell counts showed that drug-treated mice contain 20 times less bone marrow cells than normal mice, and when injected with p. berghei die significantly later than normal controls. the animals were injected with normal (nbm) and immune bone marrow and normal (nsp) and immune spleen (isp) ... | 1981 | 7025493 |
| [search for new antimalarial compounds (a review of patents)]. | 1981 | 7024774 | |
| [hemostatic system disorders in malaria (a review of the literature)]. | 1981 | 7024773 | |
| [general characteristics of the chemotherapeutic properties of a new experimental antimalarial preparation dabequin]. | 1981 | 7024771 | |
| plasmodium berghei: effect of carrageenan on the course of infection of the a/j mouse. | 1981 | 7024158 | |
| chloroquine resistant malaria: association with enhanced plasmodial protease activity. | 1981 | 7023481 | |
| babesia rodhaini and plasmodium berghei. a highly active series of chlorophenoxyalkoxy-substituted diamino-dihydrotriazines against experimental infections in mice. | 1981 | 7023398 | |
| in vitro cultivation of the exoerythrocytic stage of plasmodium berghei from sporozoites. | when inoculated with sporozoites of plasmodium berghei, the human embryonic lung cell line wi38 supports the complete asexual developmental cycle of the exoerythrocytic stage. cultured parasites were sensitive to primaquine, were shown to resemble parasites in living hosts by immunofluorescent antibody tests, and on subinoculation into mice induced a red blood cell infection, the gametocytes of which produced sporozoites in anopheline mosquitoes. | 1981 | 7022652 |
| autoantibodies to red blood cells in rats infected with plasmodium berghei. | a radio-iodinated protein a (125spa) binding assay was used to identify autoantibodies to red blood cells (rbc's) in sera of rats infected with plasmodium berghei. sera taken from rats at various times after infection were reacted with washed, normal rbc's, then the rbc's were washed and treated with 125spa. the bound radioactivity was taken as a measure of the amount of ig attached to the rbc's membranes. using this test, anti-rbc autoantibodies were detected in rat sera as early as 5 days afte ... | 1981 | 7021787 |
| endotoxin-induced serum factor kills malarial parasites in vitro. | we investigated the possibility that malarial parasites may be killed by nonspecific soluble mediators, such as those in tumor necrosis serum, that are obtained from mice given macrophage-activating agents like corynebacterium parvum or mycobacterium bovis bcg, followed by endotoxin. such sera killed parasites in vitro after overnight incubation; killing was measured directly by using an in vivo infectivity assay. parasite infectivity was not decreased by incubation in sera from mice given c. pa ... | 1981 | 7021427 |
| host defenses in murine malaria: nonspecific resistance to plasmodium berghei generated in response to mycobacterium bovis infection or corynebacterium parvum stimulation. | infection with mycobacterium bovis (bcg) or injection of killed corynebacterium parvum protected some strain b6d2 f1 (c57bl/6xdba/2) mice but did not protect strain icr or a mice from lethal challenge with plasmodium berghei strain nyu-2. b6d2 mice were not protected against challenges delivered immediately after intravenous injection of these materials, but rather protection developed by day 7 and persisted through at least day 84. infections in protected mice progressed to about 10% parasitemi ... | 1981 | 7021424 |
| effect of plasmodium berghei on membranes of murine erythrocytes. | membranes from normal and plasmodium berghei-infected mice were analyzed to determine: 1) if any antigenic changes were present; and 2) the nature of these changes. polyacrylamide gel electrophoresis (page), immunological and biochemical analyses were performed on whole ghosts and glycoprotein fractions extracted from whole ghosts by chloroform-methanol. page profiles and biochemical analyses revealed quantitative, but not qualitative, differences between membrane proteins and glycoproteins of n ... | 1981 | 7020448 |
| the effect of cryopreservation on gametocytogenesis of plasmodium berghei berghei: a preliminary report. | 1980 | 7020321 | |
| erythrocyte destruction and protective immunity to malaria: enhancement of the immune response by phenylhydrazine treatment. | malaria infection is characterized by extensive destruction of erythrocytes. in addition, the surface membrane of parasitized erythrocytes becomes biochemically and antigenically modified. thus during infection the host immune system is exposed to massive amounts of modified erythrocytes on a scale not normally considered in conventional immunological experiments. the haemocytoxic drug phenylhydrazine hydrochloride has been used to mimic, in otherwise normal animals, the effect of the modificati ... | 1981 | 7020185 |
| glucan-enhanced immunogenicity of killed erythrocyte stages of plasmodium berghei. | intravenous injections of glucan simultaneously with formalin-killed erythrocytic stages of plasmodium berghei elicited a greater degree of resistance in mice against subsequent infection with viable parasites than injections of killed erythrocytic stages alone. in two experiments with p. berghei strain nk 65, 100% of mice immunized with the glucan-dead parasite preparation survived challenge, whereas only 28.6% of mice receiving dead parasites alone survived. in the third experiment, using p. b ... | 1981 | 7019074 |
| sequestration of the chloroquine receptor in cell-free preparations of erythrocytes infected with plasmodium berghei. | when mouse erythrocytes infected with plasmodium berghei were preincubated with [14c]chloroquine and then lysed by hypotonic shock, chloroquine remained bound to the resulting cell-free preparation. in an isotonic medium at ph 7.4 and 25 degrees c, chloroquine was bound to the cell-free preparation with an apparent dissociation constant of 1.8 x 10(-7) m. the bound [14c]chloroquine could be displaced by nonradioactive chloroquine, amodiaquine, quinacrine, and mefloquine, as would be predicted fr ... | 1981 | 7018392 |
| [scanning electron microscopy study of initiation by plasmodium berghei of "metabolic windows" in the surface of parasitized erythrocytes (author's transl)]. | 1981 | 7018346 | |
| plasmodium berghei: glycolytic intermediate concentrations of the infected mouse erythrocyte. | 1981 | 7016570 | |
| pregnancy associated recrudescence in murine malaria (plasmodium berghei). | depending on the strain, a variable proportion of mice solidly immune to the rodent malaria parasite plasmodium berghei developed a recrudescence during pregnancy that was either transient or lethal. recrudescence was not observed in all mice, and the rate was lower in gravida ii as compared to gravida i mice. on the other hand a proportion of the mice that did not develop recrudescence exhibited a pregnancy associated clearance of persisting parasites in immune mice (premunition-sterile immunit ... | 1980 | 7015633 |
| active immunization and passive transfer of resistance against sporozoite-induced malaria in infant mice. | 1981 | 7015150 | |
| [synthesis and study of the acute toxicity and antiparasitic activity on 6-nitro (amino)-4-dialkylaminoalkylaminoquinolines]. | 1981 | 7015098 | |
| relationship of alterations in splenic clearance function and microcirculation to host defense in acute rodent malaria. | during the course of plasmodium berghei malaria in the rat, splenic clearance of damaged uninfected erythrocytes (heated or heinz body-containing) underwent changes strikingly similar to those of infected erythrocytes. splenic trapping of abnormal erythrocytes was impaired during the period of rising parasitemia but became supernormal just before the onset of resolution of the acute infection. these changes could be related to the development of splenomegaly and alterations in splenic cordal mic ... | 1981 | 7014635 |
| role of spleen in morbidity and mortality of plasmodium berghei infection in mice. | splenectomy has a strain-specific effect on plasmodium berghei infection in mice. mean survival time either was unchanged or increased to three times the value observed in intact controls. a delay of early mortality, which was otherwise observed in the second week of infection, was a general feature of susceptible strains. delayed mortality was also observed when splenectomy was performed shortly before expected mortality. ineffectiveness of splenectomy as to increased survival time was independ ... | 1980 | 7014442 |
| plasmodium berghei: glycolytic enzymes of the infected mouse erythrocyte. | 1981 | 7014240 | |
| an ultrastructural study of developing stages of exo-erythrocytic plasmodium berghei in rat hepatocytes. | the ultrastructure of immature exo-erythrocytic forms of plasmodium berghei in rat hepatocytes was studied at stages between 25 and 51 h of development. a new method was successfully applied to localize the parasites in a small portion of the liver by temporary ligature of blood vessels to the majority of the liver, and from the spleen and the pancreas. nuclear profiles appeared to be part of a highly lobed nuclear reticulum. peripheral vesiculation and vacuolization of the cytoplasm was increas ... | 1981 | 7012764 |
| complement does not facilitate plasmodial infections. | the influence of the complement (c) system on plasmodial infections in vivo (plasmodium berghei in rats) and in vitro (plasmodium falciparum) has been determined. in rats c3 depletion by treatment of animals with the c3 inactivator isolated from cobra venom factor results in infection that develops more rapidly, reaches a higher peak of parasitemia and is associated with an increased mortality rate (60%), in contrast to a lower degree of parasitemia and lack of mortality in c3-intact rats. the i ... | 1981 | 7012239 |
| effect of route of mycobacterium bovis bcg administration on induction of suppression of sporozoite immunity in rodent malaria. | intravenous immunization of mice with 16,000, 60co--gamma-irradiated, attenuated sporozoites produced solid immunity to sporozoite-induced malaria when the mice were challenged 21 days after immunization. in contrast, mice injected by various routes with 10(7) viable units of mycobacterium bovis (bcg) before immunization with irradiated sporozoites were not completely immune to challenge. the extent of reduced protection against viable sporozoites demonstrated with these animals was dependent up ... | 1981 | 7012001 |
| host defenses in murine malaria: analysis of plasmodial infection-caused defects in macrophage microbicidal capacities. | macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic plasmodium yoelii or plasmodium berghei infection of mice. p. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of "activated" macrophages. the uptake by spleen and liver of an intravenous challenge of listeria monocytogenes was not altered by plasmodial infection, but within hours of injection ... | 1981 | 7012000 |
| host defenses in murine malaria: failure of vaccination with formolized blood parasites to protect athymic mice from plasmodium berghei. | the thymus dependency of immunity to erythrocytic plasmodium berghei (nyu-2) infection generated in response to injections of formalin-killed mixed blood parasites was shown by the demonstration that the vaccine protected immunologically intact nu/+ mice, but not their athymic nu/nu littermates. | 1980 | 7011989 |
| two distinct types of non-specific immunosuppression in murine malaria. | a comparative study of non-specific immunosuppression by malaria has been carried out in five situations: in both unvaccinated and vaccinated mice infected with the lethal plasmodium yoelii or the lethal plasmodium berghei, and in the unvaccinated non-lethal p. yoelii infection. spleen cells showed a suppressive effect on the normal blastogenic response to mitogens. this suppression was strongest in the mice vaccinated before infection with the lethal p. yoelii and in those infected with non-let ... | 1980 | 7011609 |
| immunopathological aspects of plasmodium berghei infection in five strains of mice. ii. immunopathology of cerebral and other tissue lesions during the infection. | histological changes during the course of p. berghei infection were investigated in a/j, balb/c, of1, cba and c57b1 mice. the findings were studied in relation to serological aspects (contreras et al., 1980). high mortality and acute deaths occurred in a/j, balb/c and of1 mice and marked cerebral lesions were found in these strains from day 15, including congestion of meningeal and cerebral veins and capillaries, blocking of these vessels by heavily parasitized rbc, cerebral oedema and haemorrha ... | 1980 | 7011607 |
| immunopathological aspects of plasmodium berghei infection in five strains of mice. i. immune complexes and other serological features during the infection. | the development of circulating immune complexes was studied in mice of the balb/c, a/j, of1, cba and c57b1 strains infected with p. berghei. complexes were evaluated in relation to levels of parasitaemia, soluble antigen, specific antibody and c3. susceptibility to infection was greatest in balb/c, a/j and of/a mice. the maximum parasitaemia was 30% in cba and 70% in all other strains. levels of soluble antigen paralleled those of parasitaemia. specific antibody was detected in all strains, but ... | 1980 | 7011606 |
| quantification of hyperbaric oxygen-induced toxicity utilizing a malarial system. | this study was undertaken in recognition of the need to develop quantitative systems to evaluate the toxicity associated with hyperbaric oxygen (hbo) exposure. malaria-infected (p. berghei berghei) mice were briefly exposed to 100% oxygen at 3 ata on day 10 of infection. at 25, 48, and 72 h thereafter, the levels of circulating erythrcytes and percent parasitized rbc were monitored and compared to those of infected non-exposed controls. the total erythrocyte counts of the infected hbo-exposed an ... | 1981 | 7011300 |
| [some patterns of the in vivo plasmodium berghei entry into erythrocytes as revealed by scanning electron microscopy (author's transl)]. | 1981 | 7011156 | |
| a genetic study of the susceptibility of anopheles gambiae to plasmodium berghei. | in a study of the genetics of susceptibility and refractoriness of anopheles gambiae to plasmodium species, nine generations of selection resulted in a completely susceptible line and an entirely refractory line to plasmodium berghei (a rodent malaria). the f1 progeny from reciprocal crosses between the lines differed in their susceptibility to the parasite. backcrosses to the parent did not produce proportions of susceptible and refractory individuals consistent with single gene inheritance or ... | 1980 | 7010688 |
| vaccines against parasitic diseases - malaria. | 1980 | 7010373 | |
| [combined effect of chloroquine and quinine in rodent malaria (plasmodium berghei)]. | 1980 | 7010106 | |
| folate antagonists. 18. synthesis and antimalarial effects of n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines and related n6,n6-disubstituted 2,4,6-pteridinetriamines. | n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines (1-15) and related n6-substituted 2,4,6-pteridinetriamines (16-20) were obtained by the condensation of 6-chloro-2,4-pteridinediamine with n-methylarylmethanamine and other selected secondary amines. the requisite n-methylarylmethanamines (21-32) were prepared by the hydrogenation over pt/c of the corresponding arylcarboxaldehyde in the presence of methanamine. several of the n6-(arylmethyl)-n6-methyl-2,4,6-pteridinetriamines exhibited exception ... | 1981 | 7009868 |
| synthesis and antimalarial effects of n2-aryl-n4-[(dialkylamino)alkyl]- and n4-aryl-n2-[(dialkylamino)alkyl]-2,4-quinazolinediamines. | a series of n2(and n4)-aryl-n4(and n2)-[(dialkylamino)alkyl]-2,4-quinazolinediamines has been synthesized for antimalarial evaluation. condensation of the appropriate 2,4-dichloroquinazoline (iv) with the requisite n,n-dialkylalkylenediamine afforded a series of 2-chloro-n-[(dialkylamino)alkyl]-4-quinazolinamines (v) which were condensed with the appropriate arylamine to provide the corresponding n2-aryl-n4-[(dialkylamino)alkyl]-2,4-quinazolinediamines (vi). hydrolysis of 2,4-dichloroquinazoline ... | 1981 | 7009867 |
| permethyl analogue of the pyrrolic antibiotic distamycin a. | the synthesis of an analogue of distamycin a, a pyrrolic oligopeptide possessing antiviral and antibiotic activity, is described in which each of the three pyrrole rings is fully methylated. this structural modification results in pyrrole rings which are extraordinarily electron rich and required the development of a new synthetic approach to these polypyrrolic amides. the key reactions involved development of a general method for the synthesis of 3-aminopyrroles and for formation of an amide bo ... | 1981 | 7009865 |
| selection of a sulphanilamide resistant strain of plasmodium berghei. | 1980 | 7009422 | |
| action of chymotrypsin on experimental plasmodium berghei infection in albino mice. | 1980 | 7008478 | |
| autocytotoxins during rodent malaria. | 1980 | 7007602 | |
| evaluation of plasmodium berghei for endotoxin by the limulus lysate assay. | 1980 | 7007601 | |
| plasmodium berghei: the in vitro immune response. | 1981 | 7007068 | |
| the antimalarial activity of n-benzyloxydihydrotriazines. i. the activity of clociguanil (brl 50216) against rodent malaria, and studies on its mode of action. | 1980 | 7006531 | |
| primaquine liposomes in the chemotherapy of experimental murine malaria. | 1980 | 7006530 | |
| antimalarials. 12. preparation of carbon isosteres of selected 4-pyridinemethanols as suppressive antimalarials. | four carbon isosteres related to the highly active 4-pyridylcarbinolamines were prepared and evaluated for suppressive antimalarial activity against plasmodium berghei in mice. three of the four examples possessed significant activity but were approximately one dose level less active than the corresponding pyridines. | 1980 | 7005445 |
| complement-mediated defect in clearance and sequestration of sensitized, autologous erythrocytes in rodent malaria. | we investigated the ability of malaria-infected and normal mice to clear particulate immune complexes consisting of autologous erythrocytes sensitized with either igg or complement. normal mice rapidly clear autologous erythrocytes optimally sensitized with igg and the liver plays a major role in their sequestration. clearance of optimally sensitized erythrocytes is complement-dependent because cobra venom factor-treated, normal mice failed to clear these cells rapidly, unless they had been pre- ... | 1981 | 7005263 |
| characterization of surface proteins and glycoproteins on red blood cells from mice infected with haemosporidia: plasmodium berghei infections of balb/c mice. | the surface proteins and glycoproteins of red cells from plasmodium berghei-infected blood have been radio-isotope labelled and compared with those of normal mouse erythrocytes using the following protein labelling probes: lactoperoxidase-catalysed radio-iodination of tyrosyl residues, periodate oxidation and nab3h4 reduction of sialic acid and oxidation of galactosyl/n-acetylgalactosaminyl residues by galactose oxidase with subsequent nab3h4 reduction. during p. berghei infection, new tyrosyl-l ... | 1980 | 7003500 |
| changes in lysosomal enzymes of peritoneal exudate cells in albino rats and mastomys natalensis during plasmodium berghei infection. | activities of certain lysosomal enzymes of peritoneal exudate cells were followed during plasmodium berghei infection in two experimental hosts. in albino rats, where sterile immunity against the infection develops, levels of beta-d-glucuroniodase and acid phosphatase activities were increased several times the normal values. on the other hand, in mastomys natalensis, which succumbs to infection, levels of both the enzymes decreased considerably. cathepsin d activity did not change to a signific ... | 1980 | 7003382 |
| molecular complexes of quinoline antimalarials with iron-porphyrin components of protease-digested methemoglobin. | chloroquine, quinine, mefloquine and quinacrine have been found by difference spectroscopy to interact with hemozoin from plasmodium berghei, trypsin and pronase-digested methemoglobin, hemin, heme, protoporphyrin ix and hematoporphyrin. these drugs also compete with one another in their binding to hemin. it is proposed that the iron-porphyrin moiety of digested hemoglobin is a common binding site for the accumulation of the schizontocidal drugs in the autophagosomes of the malarial parasite. | 1980 | 7002334 |
| induction of cell-mediated responses against malarial erythrocytic stage through chemically pre-treated burkitt lymphoma tumour cells. | 1980 | 7002309 | |
| biosynthesis of uridine monophosphate in plasmodium berghei. | high activities of the enzymes orotate phosphoribosyltransferase and orotidylate decarboxylase, that convert orotic acid to uridine monophosphate, have been demonstrated in crude supernatants obtained from lysed plasmodium berghei. the enzymes are inhibited in vitro by 5-azaorotate, 5-azauracil and 6-azauracil. of these, 5-azaorotate was the most effective and could serve as the prototype of a potential antimalarial. | 1980 | 7002072 |
| culture of the liver stages (exoerythrocytic schizonts) of rodent malaria parasites from sporozoites in vitro. | 1980 | 7001683 | |
| endotoxin in human and murine malaria. | 1980 | 7001682 | |
| cellular changes in the bone marrow of plasmodium berghei-infected mice. ii. blast transformation and phagocytosis. | 1980 | 7000373 | |
| binding of antimalarial drugs to hemozoin from plasmodium berghei. | chloroquine, quinacrine and mefloquine bind to plasmodium berghei hemozoin, hemin, hemi, protoporphyrin ix and protease digested methemoglobin. this binding may be the basis for drug accumulation and action in the parasite. | 1980 | 6998717 |
| cold isohaemagglutinins in plasmodium berghei-infected rats reacting with parasitized reticulocytes. | significant levels of cold igm and igg isohaemagglutinins were detected in the serum of rats infected with plasmodium berghei ksp 11. peak titres occurred 15 days after initial infection at the time when the parasitaemia was dropping rapidly, or 7 days after a second challenge infection. infected reticulocytes were much more sensitive to agglutination than uninfected cells, but absorption experiments demonstrated isoantigenicity in the determinants involved. this result indicated that the presen ... | 1980 | 6998593 |
| enhanced fusion capacity of malaria (plasmodium berghei)-infected mouse red cells. | the capacity of normal and malaria-infected mouse red cells to undergo fusion was investigated by phase contrast microscopy. the fusion of mouse red cells induced by 50% w/w poly(ethylene glycol)-6000 in the presence of ca+2 is enhanced by p. berghei infection. cells carrying parasites in the ring form stage and early trophozoite stage show slightly higher fusion induced by dimethyl sulphoxide and ca+2 than those carrying parasites in trophozoite and schizont stages. | 1980 | 6998573 |
| 10-hydroxy-3,4-dihydroacridine-1,9(2h,10h)-diones, a new group of malaricidal and coccidiostatic compounds. | 2-nitrobenzaldehydes and 1,3-cyclohexanediones condense in a mixture of hydrochloric acid and glacial acetic acid to 10-hydroxy-3,4-dihydroacridine-1,9(2h,10h)-diones. many compounds of this group reveal a pronounced coccidiostatic and malaricidal effect in vivo even against drug-resistant malaria parasites. synthesis and chemotherapeutic results as well as structure-activity relationships are described. | 1980 | 6998488 |
| distribution of chloroquine in normal, pronase-treated and malaria-infected red cells. | 1980 | 6995763 | |
| host responses induced in mice by a radiation-attenuated plasmodium berghei (nk65) malaria parasite. | 1980 | 6995369 | |
| depressed malarial immunity in pregnant mice. | a proportion of mice solidly immune to the rodent malaria parasite plasmodium berghei exhibited a pregnancy-associated depressed immunity with a transient or even lethal recrudescence. | 1980 | 6995314 |
| xanthine oxidase increase in polymorphonuclear leucocytes and macrophages in mice in three pathological situations. | 1980 | 6994749 | |
| liver xanthine oxidase increase in mice in three patholgoical models. a possible defence mechanism. | 1980 | 6994748 | |
| the chemotherapy of rodent malaria, xxxii. the influence of p-aminobenzoic acid on the transmission of plasmodium yoelii and p. berghei by anopheles stephensi. | more oocysts of plasmodium yoelii developed in anopheles stephensi if the mosquitoes received a supplement of p-aminobenzoic acid (paba) in their diet prior to their taking an infective blood meal, than in unsupplemented control insects. the optimum concentration was 0.05% paba in 10% sucrose. this effect was not observed if the blood meal was taken prior to feeding with paba. similarly, paba administered to gametocyte-carrying mice increased the numbers of oocysts developing in mosquitoes fed o ... | 1980 | 6994664 |
| [morphological incidences of the agglutination of the erythrocytes of healthy or infested (plasmodium berghei) mouse by various experimental immune sera (author's transl)]. | 1980 | 6994569 | |
| structure-activity analyzed by pattern recognition: the asymmetric case. | in classification studies in which pattern-recognition methods are used to distinguish active compounds from inactive ones, a type of data structure which we call "asymmetric" can be observed. this type of data structure can be quite common and its occurrence can have a profound effect on the classification analysis outcome. the origin of asymmetric data structure and a strategy or obtaining meaningful classification results when it is observed are discussed and illustrated with an example of ac ... | 1980 | 6993681 |
| immunization of rats against malaria: a new model. | 1980 | 6993642 | |
| purine base and nucleoside uptake in plasmodium berghei and host erythrocytes. | the absorption of 3h-labeled adenine, adenosine, hypoxanthine, and 14c-labeled inosine by normal rat erythrocytes, plasmodium bergheri-infected erythrocytes and saponin released "free parasites" was measured. the uptake of these labeled substrates by normal rat erythrocytes occurs both by diffusion and mediated transport systems. similar absorptive mechanisms for these substrates also were observed for both plasmodium berghei-infected erythrocytes and "free parasites." data from inhibition studi ... | 1980 | 6993639 |
| immunization against rodent malaria with cryopreserved irradiated sporozoites of plasmodium berghei. | the preparation and storage of plasmodium berghei sporozoites for immunization purposes is described. the sporozoites were harvested from the salivary glands of infected mosquitoes, and maintained in cold tissue culture medium m199 with or without mouse serum. they were irradiated and frozen either at -75 degrees c or in liquid nitrogen. after various periods sporozoites were thawed and injected into a/j mice. at the end of the immunization period the animals were challenged with infective sporo ... | 1980 | 6992606 |
| the diagnosis of malaria infection using a solid-phase radioimmunoassay for the detection of malaria antigens. application to the detection of plasmodium berghei infection in mice. | a method has been devised to show that malaria parasites can be detected serologically in infected blood with a high degree of sensitivity. using a murine malaria model, parasites were demonstrated in a solid-phase radio-immunoassay which measured antibody-binding inhibition. lysed red blood cells (r.b.c.) were incubated with labelled specific antibody and were then reacted in antigen-coated tubes. the degree of inhibition of antibody binding in the tubes correlated with the level of parasitaemi ... | 1980 | 6992060 |
| synthesis of potential inhibitors of hypoxanthine-guanine phosphoribosyltransferase for testing as antiprotozoal agents. 1. 7-substituted 6-oxopurines. | biological evidence indicates that the enzyme hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) is vital for cell proliferation in malarial parasites but nonessential for mammalian cells. 7-substituted guanines and hypoxanthines in which the 7 substituent bears functional or hydrophobic groups were prepared with the aim of finding a suitably constituted compound whose resemblance to the normal substrate allows it to compete for the reversible purine binding site of hgrptase while allow ... | 1980 | 6991691 |
| monovalent fragments (fab) of monoclonal antibodies to a sporozoite surface antigen (pb44) protect mice against malarial infection. | monoclonal antibodies (ig1, k) directed against a surface component of plasmodium berghei sporozoites (pb-44) confer complete protection to mice against a lethal inoculum of parasites. the degree of protection is a function of the number of parasites used in the challenge and of the antibody concentration in serum. passive transfer of 10 micrograms of antibody per mouse abolished or profoundly diminished the infectivity of 10(3) sporozoites, but much higher amounts of antibody were required for ... | 1980 | 6991628 |
| isolation of a soluble component of plasmodium berghei which induces immunity in rats. | soluble material was obtained from sonically freed plasmodiae by three procedures. two procedures, cryo-impacting and freeze-thawing, were evaluated for their ability to disrupt the parasites and release soluble material. the soluble materials obtained by these procedures were compared to materials washed from the surfaces of sonically freed parasites. between 35 and 40% of the total parasite protein was solubilized by freeze-thawing or cryo-impacting. one cycle of freeze-thawing released nearly ... | 1980 | 6991439 |
| ferriprotoporphyrin ix fulfills the criteria for identification as the chloroquine receptor of malaria parasites. | 1980 | 6990976 | |
| the inhibitory effect of a drug combination on the development of mefloquine resistance in plasmodium berghei. | 1980 | 6990883 | |
| [structure dependance of antiplasmodic activity of 3-[n-(4-amidosulfonylphenyl)aminomethyl]-quinoline (author's transl)]. | 1980 | 6989342 | |
| changes in the membrane microviscosity of mouse red blood cells infected with plasmodium berghei detected using n-(9-anthroyloxy) fatty acid fluorescent probes. | a set of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12, 16) have been used as fluorescent probes to examine the lipid environment at different depths in the outer membrane of normal mouse erythrocytes and red blood cells from plasmodium berghei-infected blood. fluorescent polarization experiments with normal mouse erythrocytes have demonstrated a typical gradient in microviscosity from the surface to the centre of the bilayer as a consequence of the motional properties of the c-atoms of the pho ... | 1980 | 6988766 |
| a solid-phase antibody binding-inhibition test, for the assay of plasmodium berghei antigen and antibodies, using radioiodinated protein a. | sonicated red blood cells (rbc) of rats infected with plasmodium berghei (pb) were used to coat plastic tubes with pb antigens. the antigen-coated tubes were employed to detect pb antigens and antibodies, with high efficiency. anti-pb antibodies were estimated by treating the tubes with rabbit or rat anti-pb sera and assaying the bound ig with radiolabeled staphylococcus pra. pb antigens were detected by their capacity to inhibit the binding of the anti-pb antibodies. using a rabbit-pb serum, so ... | 1980 | 6987313 |
| effect of selenium and dimethyl dioctadecyl ammonium bromide on the vaccine-induced immunity of swiss-webster mice against malaria (plasmodium berghei). | the results of the study described in this paper demonstrate that selenium, administered in drinking water, potentiates the protective effect of a killed plasmodium berghei vaccine for swiss-webster mice. we also report that a vaccine consisting of p. berghei antigen combined with the adjuvant dimethyl dioctadecyl ammonium bromide conferred a significantly high level of protective immunity. an additive effect was shown in that the greatest degree of protection was afforded to the group of mice m ... | 1980 | 6987181 |
| host defenses in murine malaria: immunological characteristics of a protracted state of immunity to plasmodium yoelii. | random-bred icr mice recovered from infection with avirulent plasmodium yoelii were challenged at various later times with virulent p. yoelii or with another species of plasmodium, p. berghei, to characterize the immunological nature of the long-term state of immunity generated in response to the avirulent infection. it was found that recovered mice resisted lethal challenge with virulent p. yoelii through at least 416 days after primary infection. however, the quality of this immunity changed a ... | 1980 | 6987179 |