Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| structural aspects of pathology in alzheimer's disease. | the characteristic lesions of alzheimer's disease, neurofibrillary tangles and neuritic plaques, are the sites of accumulation of abnormal fibrillar material. the structure of the paired helical filament from tangles has been analysed by electron microscopy and biochemical studies have shown that it contains microtubule associated protein tau as a component. fibrils of beta-amyloid in the neuritic plaque arise by polymerization of a small proteolytic fragment of a much larger precursor protein. ... | 2008 | 2268679 |
| [bacteriology and epidemiology of shigellas isolated at the army hospital in djibouti]. | in a space of 26 months 108 shigellas were isolated from 104 patients with sporadic and benign diseases. 90% of the subjects were young french. both s. dysenteriae and s. boydii make up 21% of the strains studied. 13% of the germs are multiresistance. multiresistance can enhance development of serious sickness if a virulent strain comes in. | 1990 | 2263188 |
| [foreign bodies of the digestive tract]. | 2008 | 2259119 | |
| the differential efficacy of antihypertensive agents in the elderly. | a number of controlled trials have shown that antihypertensive therapy is beneficial to the elderly (greater than or equal to 60 years of age). even so, there may be deleterious age-related effects associated with such therapy. because of physiological and pathophysiological problems peculiar to the elderly (many of which remain to be defined precisely), both benefits and untoward effects of antihypertensive drugs differ, sometimes within classes of agents themselves. none of the traditional age ... | 2008 | 2258887 |
| residual effectiveness of insecticides for control of german cockroaches (dictyoptera: blattellidae) in food-handling establishments. | residual effectiveness of insecticides was compared for two treatment methods at various sites within two commercial kitchens. for all sites and insecticides, german cockroach, blattella germanica (l.), mortality was greatest for treatments of cracks and crevices than for treatments of exposed surfaces. mortality at the dishwashing site was lower than at all other sites. we attributed reduced mortality at the dishwashing site to a higher vapor pressure deficit. mortality and the amount of insect ... | 2007 | 2258513 |
| residual effectiveness of insecticides for control of german cockroaches (dictyoptera: blattellidae) in food-handling establishments. | residual effectiveness of insecticides was compared for two treatment methods at various sites within two commercial kitchens. for all sites and insecticides, german cockroach, blattella germanica (l.), mortality was greatest for treatments of cracks and crevices than for treatments of exposed surfaces. mortality at the dishwashing site was lower than at all other sites. we attributed reduced mortality at the dishwashing site to a higher vapor pressure deficit. mortality and the amount of insect ... | 2007 | 2258513 |
| [bacillary dysentery--1988]. | 1990 | 2251385 | |
| [surgical scoliosis therapy using vds and harrington instrumentation (ventral derotation spondylodesis)]. | the vds-method in accordance to zielke and the harrington-distraction-spondylodesis are proved as methods for correction of scoliosis lasting for decades, which late results are world-wide analysed and published. the both diametrical corrective principles and the fundamental different operative techniques settle their different indications, which doubtless depend on the experience of the surgeon. both methods complete each other in operative spectrum of the spinal surgeon. a careful study of the ... | 2008 | 2248610 |
| correlation between beta 2-microglobulin and soluble interleukin-2 receptor levels in plasma of individuals living in a malarial endemic region. | beta 2-microglobulin (beta 2m) levels were related to the expected immunoprotection in 81 individuals living in a malarial mesoendemic area near bobo-dioulasso (burkina faso), who were longitudinally followed. soluble interleukin-2 receptor (sil-2r) levels were positively correlated to those of beta 2m (r = 0.44; n = 237; p less than 0.001). this suggests that most of the beta 2m could have originated from activated t and b cell membrane turnover. in our study, both beta 2m and sil-2r were inver ... | 1990 | 2242964 |
| mechanism of the vasodilator action of pinacidil. | the mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. the results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards k+ permeability. second, the results confirm that the vasodilator effect of pinacidil is due to an increase in k+ permeability. lastly, the results suggest that the k+ channels involved are sensitive to glibenclamide. | 1990 | 2242449 |
| methotrexate as an adjunct in the treatment of persistent mild cardiac allograft rejection. | because methotrexate arrests inflammation in autoimmune disease, we studied its efficacy in persistent low-grade cardiac allograft rejection. seventeen patients aged 39.5 +/- 0.9 years (mean +/- se) had persistent rejection despite previous therapy with high dose corticosteroids. maintenance immunosuppression consisted of prednisone, azathioprine, and cyclosporine. the rejection episode treated with methotrexate occurred 180 +/- 55.4 days posttransplantation. patients had incurred 2.7 +/- 0.3 pr ... | 2007 | 2238053 |
| methotrexate as an adjunct in the treatment of persistent mild cardiac allograft rejection. | because methotrexate arrests inflammation in autoimmune disease, we studied its efficacy in persistent low-grade cardiac allograft rejection. seventeen patients aged 39.5 +/- 0.9 years (mean +/- se) had persistent rejection despite previous therapy with high dose corticosteroids. maintenance immunosuppression consisted of prednisone, azathioprine, and cyclosporine. the rejection episode treated with methotrexate occurred 180 +/- 55.4 days posttransplantation. patients had incurred 2.7 +/- 0.3 pr ... | 2007 | 2238053 |
| [new aspects of intolerance of the aqueous iodinated x-ray contrast medium, adipiodone--fatal interaction of adipiodone-ultrabil with the immunomodulators corynebacterium parvum (cp) and shigella dysenteriae endotoxin (lps)]. | the authors assume a new type of interaction of the aqueous x-ray contrast substance type adipiodone (ultrabil 50% spofa) with immunomodulators of corynebacterium parvum (cp) and the endotoxin of shigella dysenteriae (lps). the fatal type of interaction developed regularly as a result of the concurrent i.v. administration of the x-ray contrast substance adipiodone with the endotoxin of shigella dys. (lps) to laboratory animals (mice) which had five days previously a single dose of corynebacteriu ... | 1990 | 2237238 |
| plasmid profiles of shigella dysenteriae type 1 isolates from ethiopia with special reference to r-plasmids. | plasmid profiles of 80 shigella dysenteriae type 1 (shiga's bacillus) strains, collected between 1974 and 1985 in ethiopia, were examined. strains with the dominant antibiotic-resistance (r-) type--resistance to ampicillin (a), chloramphenicol (c), streptomycin (s), sulphadiazine (su) and tetracycline (t)--showed two distinct plasmid profiles (pp). six plasmid bands were demonstrated in "ethiopian strains" with pp-1a isolated between 1974 and 1982. in mating experiments with these strains, esche ... | 1990 | 2231675 |
| differentiation of shiga toxin and vero cytotoxin type 1 genes by polymerase chain reaction. | two sets of synthetic oligonucleotide primers were used in a polymerase chain reaction technique to distinguish genes for shiga toxin in shigella dysenteriae 1 and type 1 vero cytotoxin (vt1) in escherichia coli. vt1a and vt1b primers directed at a common 130-base-pair (bp) fragment of the stx and slti genes detected template nucleic acid in both shiga toxin-positive s. dysenteriae 1 and vt1-producing e. coli strains. vt1c and vt1d primers, targeting a 140-bp fragment of the promoter region of t ... | 1990 | 2230244 |
| thermodynamic properties of globular proteins and the principle of stabilization of their native structure. | a semi-empirical method has been used to estimate the thermodynamic parameters of hydration of buried surface areas of ribonuclease s, lysozyme and myoglobin from the model of complete unfolding according to ooi et al. ((1987) proc. natl. acad. sci. usa 84, 3086-3090). the buried surface area of proteins is considered as the difference between the accessible surface area of native protein and the completely extended polypeptide chain according to lee and richards ((1971) j. mol. biol. 55, 379-40 ... | 2008 | 2223840 |
| normal early pregnancy: serum hcg levels and vaginal ultrasonography findings. | vaginal sonography and determination of serum hcg levels were carried out in 22 healthy pregnant women every 2 to 4 days after the first positive pregnancy test until a living fetus was observed. gestational age was calculated from the day of ovulation, assessed by lh surge or hcg administration, plus 14 days. a gestational sac of 1-3 mm was detected at a mean (sem) of 31.2 (0.2) days of gestation (range 30-33 days). the corresponding mean hcg level was 730 iu/l (30) and the range 467-935 iu/l ( ... | 2007 | 2223680 |
| normal early pregnancy: serum hcg levels and vaginal ultrasonography findings. | vaginal sonography and determination of serum hcg levels were carried out in 22 healthy pregnant women every 2 to 4 days after the first positive pregnancy test until a living fetus was observed. gestational age was calculated from the day of ovulation, assessed by lh surge or hcg administration, plus 14 days. a gestational sac of 1-3 mm was detected at a mean (sem) of 31.2 (0.2) days of gestation (range 30-33 days). the corresponding mean hcg level was 730 iu/l (30) and the range 467-935 iu/l ( ... | 2007 | 2223680 |
| parathyroid gland disease and hypercalcemia. | 2007 | 2223448 | |
| parathyroid gland disease and hypercalcemia. | 2007 | 2223448 | |
| hemolysin as a marker for serratia. | all serratia marcescens strains (total of 33) of different sources were hemolytic including clinical strains previously classified as being nonhemolytic. dna fragments of the two hemolysin genes hybridized with the chromosomal dna of s. marcescens, s. liquefaciens, s. kiliensis, s. grimesii, s. proteamaculans, s. plymutica, s. rubridaea which were also hemolytic. the restriction pattern of the hemolysin locus differed in each strain. s. ficaria and s. marinorubra expressed a different hemolysin ... | 1990 | 2222120 |
| immunolabelling of shiga toxin in macrophages infected with shigella dysenteriae 1. | immunolabelling of shiga toxin in macrophages infected with a non-invasive shigella dysenteriae 1 isolate showed that bacteria remained alive for 3 h after ingestion within the phagocytic vacuole and synthesized shiga toxin. the normal process of toxin secretion was, however, impaired by the phagosomal environment and toxin molecules accumulated within the bacterial cytoplasm. | 1990 | 2218059 |
| plants used in guatemala for the treatment of gastrointestinal disorders. 1. screening of 84 plants against enterobacteria. | gastrointestinal disorders are important causes of morbidity in developing countries. natural healing is the traditional way of treating these diseases in guatemala. ethnobotanical surveys and literature reviews showed that 385 plants from 95 families are used in guatemala for the treatment of gastrointestinal disorders. the activity of 84 of the most commonly used plants was screened in vitro against five enterobacteria pathogenic to man (enteropathogenic escherichia coli, salmonella enteritidi ... | 1990 | 2214824 |
| gorham's syndrome (massive osteolysis): a case report. | 2004 | 2213318 | |
| total hip arthroplasty after fracture of the acetabulum. long-term results. | we made a retrospective study of 55 primary total hip arthroplasties in 53 patients with a history of previous acetabular fracture. the mean follow-up was 7.5 years and the average age at fracture was 48.7 years. the incidence of radiographic femoral loosening (29.4%), symptomatic loosening (15.7%), and femoral revision (7.8%) were similar to those previously reported at 10 years for routine arthroplasties by stauffer (1982). on the acetabular side, the incidence of radiographic loosening (52.9% ... | 2007 | 2211750 |
| synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives. | the synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. both series possess potent antibacterial activity. among them, 3-[(z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum. | 2008 | 2211378 |
| cell surface proteins from shigella dysenteriae type 1. | a simple extraction procedure was used for preparing cell surface proteins (csps) from shigella dysenteriae type 1. the preparations obtained using either buffer or water extractions were free from lipopolysaccharide (lps), as well as cytoplasmic and periplasmic proteins. by sds-page, about 25 polypeptides were detected, and western-blot analysis recognised 15 polypeptide antigens. when analysed by crossed immunoelectrophoresis, using anti-shigella dysenteriae type 1 rabbit sera, 18 antigenic ba ... | 1990 | 2206198 |
| [detection of two shiga-like toxins from escherichia coli o157:h7 isolates by the polymerase chain reaction method]. | fourteen isolates of e. coli o157:h7 and five isolates of s. dysenteriae type-1 were examined by polymerase chain reaction (pcr) for the structural genes (slt-i or slt-ii), encoding shiga-like toxins (slts). the two primer pairs (v1; 5'agttaatgtggtggcgaa and v2; 5'gactgcgtcagtgaggtt for slt-i, v3; 5'ttcggtatcctattcccg and v4; 5'tctctggtcattgtatta for slt-ii) used were of the same positions representing the dna sequence covering 471bp of the slt-i or slt-ii. a 5-microliter portion of boiled bacte ... | 1990 | 2205737 |
| [a case of shigellosis due to shigella dysenteriae 1 which was thought to be infected in domestic area]. | a 43-year-old man was admitted to our hospital because of bloody diarrhea and abdominal pain on january 10, 1989. on laboratory examination s. dysenteriae 1 was isolated from his stool, therefore he was diagnosed as shigellosis. after the administration of ofloxacin was started, s. dysenteriae 1 was immediately eradicated. but his diarrhea persisted until the 19th day from the onset of the illness and his abdominal pain persisted until the 21st day. he had never been overseas and he had never ea ... | 1990 | 2205674 |
| recent advances in understanding the pathogenesis of the hemolytic uremic syndromes. | one of the requirements for an agent to cause hemolytic uremic syndrome (hus) is its ability to injure endothelial cells. shiga-like toxin (slt) can do this. slt is produced by escherichia coli and shigella dysenteriae serotype 1; both have been implicated as causes of typical hus. endothelial cells have receptors (gb3) for slt and the toxin can inhibit eukaryotic protein synthesis, thereby causing cell death. glomerular endothelial cell injury or death results in a decreased glomerular filtrati ... | 1990 | 2205273 |
| new approach to develop a vaccine design against shigellosis. | 1990 | 2204244 | |
| carboxy-terminal peptides from the b subunit of shiga toxin induce a local and parenteral protective effect. | two synthetic peptides corresponding to overlapping sequences from the c-terminus of the b chain of shiga toxin were prepared and characterized. these peptides consisted of residues 54-67 and 57-67 in the protein sequence. this region coincides with the major peak of surface area residues, as predicted from a computer-derived plot. for the purpose of immunization, the peptides were either conjugated with a protein or a synthetic carrier, or were polymerized. polyclonal antibodies against these p ... | 1990 | 2203962 |
| in vitro activity of ljc10,627, a new carbapenem antibiotic with high stability to dehydropeptidase i. | the in vitro activity of ljc10,627, a new carbapenem, was compared with those of imipenem and ceftazidime. ljc10,627 had broad-spectrum activity against gram-positive and gram-negative clinical isolates. the mics of this compound for 90% of members of the family enterobacteriaceae tested (mic90s), including strains resistant to ceftazidime, ranged from 0.1 to 25 micrograms/ml. ljc10,627 inhibited pseudomonas aeruginosa at an mic90 of 3.13 micrograms/ml; it thus was twofold more active than imipe ... | 1990 | 2203313 |
| haemolytic uraemic syndrome with shigella. | a 49-year-old male developed bloody diarrhoea whilst on a visit to india. sigmoidoscopy and rectal biopsy showed acute colitis. shigella dysentery type i was isolated from stool culture. cytotoxin production by the organism was demonstrated. the patient developed acute renal failure, thrombocytopaenia and microangiopathic haemolytic anaemia. he required mechanical ventilation, haemodialysis, blood transfusion and antibiotic therapy and achieved a complete recovery. this is an unusual case of hae ... | 1990 | 2202698 |
| plasmid profiles of antibiotic-resistant shigella dysenteriae types 2, 3, 4, 6 and 7 isolated in ethiopia during 1976-85. | plasmid profile analysis by agarose gel electrophoresis was carried out on 37 drug-resistant strains of shigella dysenteriae types 2, 3, 4, 6 and 7. these strains were collected between 1976 and 1985 in addis ababa, ethiopia. the plasmid profile of s. dysenteriae type 2 strains with r-type cssut did not show middle-sized plasmids likely to code for cssut resistance. all strains contained a large plasmid of about 120 megadaltons (mda), and a cryptic plasmid of about 2.2 mda. the plasmid profiles ... | 1990 | 2200703 |
| plasmid profile analysis and antimicrobial susceptibility patterns of shigella isolates from nigeria. | in an epidemiological survey, plasmid profiles and antimicrobial susceptibility testing of 100 shigella isolates in lagos, nigeria was done. all the isolates were sensitive to nalidixic acid, nitrofurantoin and ciprofloxacin. the commonest antimicrobial susceptibility pattern was resistance to ampicillin, colistin sulphate, co-trimoxazole, streptomycin and tetracycline. all but 4 of 100 isolates screened contained one or more plasmids. plasmid profile analysis distinguished more strains than did ... | 1990 | 2200702 |
| epidemiology of shigellosis in teknaf, a coastal area of bangladesh: a 10-year survey. | the epidemiological data on shigellosis in teknaf, a coastal area of bangladesh, were reviewed for a 10-year period (1975-84). certain similarities and differences were observed in the epidemiology of the disease in teknaf when compared with urban dhaka and rural matlab. similarities included: round-the-year infection with two peaks, one in the monsoon period and the other in the winter period; high male to female attendance ratio at the treatment centre; the predominance of infection in the und ... | 1990 | 2200700 |
| polymerase chain reaction for detection of invasive shigella flexneri in food. | the polymerase chain reaction (pcr) was used to amplify a 760-base-pair (bp) fragment with the 220-kbp invasive plasmids of enteroinvasive escherichia coli, shigella flexneri, shigella dysenteriae, shigella boydii, and shigella sonnei as templates. this pcr product was easily detected by agarose gel electrophoresis. a 210-bp acci-psti fragment lying within the amplified region was used as a probe in southern hybridization blots and showed that the pcr-generated product was derived from the invas ... | 1990 | 2200336 |
| production of shiga-like toxin among escherichia coli strains and other bacteria isolated from diarrhea in são paulo, brazil. | an elevated level of shiga-like toxin i (slt-i) production was found in 1 of 466 escherichia coli strains studied. among the 34 sonic lysates obtained from classical enteropathogenic e. coli, 5 produced slt-i. the aeromonas, citrobacter, edwardsiella, enterobacter, klebsiella, proteus, providencia, pseudomonas, salmonella, serratia, shigella, yersinia, and vibrio strains also studied were not slt producers, except for a shigella dysenteriae type 1 strain. although slt-i-producing e. coli strains ... | 1990 | 2199511 |
| comparative study of attachment to and invasion of epithelial cell lines by shigella dysenteriae. | henle 407 and hela cells were compared as hosts for shigella dysenteriae at a low multiplicity of infection. efficiency of attachment and invasion without centrifugation, as well as selectivity for pathogenic over nonpathogenic s. dysenteriae without congo red, were much greater for henle 407 cells than for hela cells. | 1990 | 2194970 |
| dna sequence analysis of pgla and mechanism of export of its polygalacturonase product from pseudomonas solanacearum. | the pgla gene encodes a 52-kilodalton extracellular polygalacturonase (pga) which is associated with the phytopathogenic virulence of pseudomonas solanacearum. the nucleotide sequence of pgla and the putative amino acid sequence of the pga protein were determined. a computer search identified a 150-residue region of pga which was similar (41%) to the amino acid sequence of a region of the pg-2a polygalacturonase from tomato. comparison of the amino terminus of the pgla open reading frame with th ... | 1990 | 2193922 |
| [antibiotic resistance of strains of shigella dysenteriae and flexneri isolated in tananarive and on the east coast of madagascar]. | from november 1988 to march 1989, stools from 804 malagasy children were examined, thirty-seven strains of shigella were isolated, from which 5 s. dysenteriae serotype 1 (= shiga bacillus) strains were found to be resistant to ampicillin, carbenicillin, streptomycin, chloramphenicol, tetracycline, sulphonamide and even to trimethoprim. resistance to trimethoprim has appeared only recently in madagascar. | 1990 | 2190702 |
| imaging the carpal tunnel. | 2001 | 2190578 | |
| rapid and specific detection of verotoxin genes in escherichia coli by the polymerase chain reaction. | a set of four synthetic oligonucleotide probes derived from sequences of the vt1 (shiga-like toxin i [slt-i]) and vt2 (slt-ii) genes were used in a polymerase chain reaction (pcr) amplification procedure to detect these genes in some enteric pathogens. a total of 40 verotoxin-producing escherichia coli strains and 43 isolates of other recognized enteric pathogens were studied. pcr amplification products identifying the vt1 and vt2 gene sequences were observed only in nucleic acid extracted from ... | 1990 | 2182671 |
| trimethoprim resistance gene in shigella dysenteriae 1 isolates obtained from widely scattered locations of asia. | trimethoprim-resistance genes of shigella dysenteriae 1 strains, isolated from a different location of six different countries of asia over a 5-year period were characterized by using three different dihydrofolate reductase (dhfr) gene probes. the trimethoprim-resistant (tmpr) strains hybridized only with the type i dhfr gene probe by colony hybridization. none of the strains hybridized with types ii and iii dhfr gene probes. southern blot experiments using plasmid dna extracted from these resis ... | 1990 | 2182327 |
| a model for evaluation of gas exchange: mouth to mouth ventilation of infants by emergency medical technicians. | we describe a model for evaluating techniques of infant ventilation during resuscitation. the utility of the model is illustrated by testing performance of emergency medical technicians in mouth to mouth ventilation of a model 4 kg infant. ventilation was generally adequate with mean (+/- s.d.) frequency 22 +/- 9 breaths per minute and tidal volume 40 +/- 13 ml. gas delivered to the model consisted of pico2 7 +/- 6 mmhg and fio2 0.20 +/- 0.007. assuming normal metabolic rate and respiratory dead ... | 2008 | 2174185 |
| [shiga and shiga-like toxins]. | 1990 | 2173117 | |
| neutralization of poliovirus by cell receptors expressed in insect cells. | to examine the interaction of the poliovirus receptor (pvr) with virus and the role of the pvr in virus entry, the pvr was expressed in insect cells. poliovirus bound to insect cells infected with a recombinant baculovirus (acpvr) carrying cdna encoding the pvr. antibodies raised against pvr expressed in bacteria immunoprecipitated a 67-kilodalton polypeptide from cytoplasmic extracts of acpvr-infected cells. treatment of acpvr-infected cells with tunicamycin revealed that the pvr is a glycoprot ... | 1990 | 2168959 |
| associations of escherichia coli k-12 ompf trimers with rough and smooth lipopolysaccharides. | the associations of both rough and smooth lipopolysaccharides (lps) with the ompf porin of escherichia coli k-12 were examined in gale strains deleted for ompc. transformation with pss37 and growth with galactose conferred the ability to assemble a shigella dysenteriae o antigen onto the core oligosaccharide of e. coli k-12 lps. the association of lps with ompf trimers was assessed by staining, autoradiography of lps specifically labeled with [1-14c]galactose, and western immunoblotting with a m ... | 1990 | 2168378 |
| the antiphospholipid antibody dilemma. | 2007 | 2168305 | |
| transposition in shigella dysenteriae: isolation and analysis of is911, a new member of the is3 group of insertion sequences. | twenty-nine clear-plaque mutants of bacteriophage lambda were isolated from a shigella dysenteriae lysogen. three were associated with insertions in the ci gene: two were due to insertion of is600, and the third resulted from insertion of a new element, is911. is911 is 1,250 base pairs (bp) long, carries 27-bp imperfect terminal inverted repeats, and generates 3-bp duplications of the target dna on insertion. it was found in various copy numbers in all four species of shigella tested and in esch ... | 1990 | 2163395 |
| [antibiotic resistance of shigella isolated in the kara-kalpak a.s.s.r. 1987-1988]. | sensitivity of shigella spp. isolated in one of the hospitals of nukus within 1987-1988 and earlier in 1977 and 1985 was studied. s. flexneri 1-5 remained the main causative agents of dysentery on the territory. however, beginning from 1987 there were registered cases of dysentery caused by s. dysenteriae 1. the isolates were most sensitive to cefotaxime, cephaloridine, polymyxin b and gentamicin. the majority of the isolates were resistant to tetracycline, levomycetin (chloramphenicol) and stre ... | 1990 | 2144726 |
| effects of chronic non-ketotic diabetes and aging on myocardial function and fatty acid oxidation. | the effects of aging and chronic non-ketotic diabetes on contractile properties, oxygen consumption, palmitate oxidation and morphology were studied in isolated, perfused working hearts of 2, 9, 12 and 22 month old rats. the heart rate, coronary flow, and oxygen consumption were no different among the 9, 12 and 22 month control and diabetic hearts. cardiac work was not depressed in control hearts until 22 months of age. depression of cardiac output due to aging in the control hearts progressed i ... | 1990 | 2141842 |
| clonal deletion of self-reactive t cells at the early stage of t cell development in thymus of radiation bone marrow chimeras. | sequential appearance of t cell subpopulations occurs in the thymocytes of irradiated c3h/he mice (h-2k, mls-1b2a, thy-1.2) after transplantation with bone marrow cells of akr/j mice (h-2k, mls-1a2b, thy-1.1) (akr----c3h chimeras). the donor-derived thymocytes of akr----c3h chimeras on day 14 after bone marrow transplantation (bmt) contained a large number of blastlike cd4+cd8+ cells which represent relatively immature thymocytes, whereas those on day 21 after bmt consisted of small sized cd4+,c ... | 2004 | 2141619 |
| kinetic analysis of 3-quinuclidinyl 4-[125i]iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: implications for human studies. | radioiodinated r- and s-quinuclidinyl derivatives of rs-benzilate (r- and s-125iqnb) have been synthesized for quantitative evaluation of muscarinic acetylcholine receptor binding in vivo. two sets of experiments were performed in rats. the first involved determining the metabolite-corrected blood concentration and tissue distribution of tracer r-iqnb (active enantiomer) and s-iqnb (inactive enantiomer) in brain 1 min to 26 h after intravenous injection. the second involved the measurement of br ... | 1990 | 2134838 |
| training of specialists for the biomedical sciences in the ussr. | 1998 | 2132951 | |
| [a scapular osteo-cutaneous flap in mandibular reconstruction]. | the authors report their experience with 6 cases involving the scapular t.o.l.v. technique described by swartz et coll. they review the anatomy of the vascularisation of the flap together with the possible operative techniques. the 6 cases involved mandibular reconstruction following transmandibular bucco-pharyngectomy, either as first or second line surgery. in all cases the osteo-cutaneous flap gave a good quality reconstruction both in terms of oro-bucco-pharyngoplasty and in terms of repair ... | 1973 | 2130448 |
| effective induction immunosuppression for cadaver renal transplantation at the st. francis regional medical center. | the okt3 induction protocol, when compared to a conventional drug protocol, resulted in an improvement in both short- and long-term patient and graft survival, especially in patients receiving a primary transplant. the 1-year allograft survival in primary transplants receiving okt3 induction was 91% and the t1/2 of 13.5 years. this was accomplished while still being able to minimize the total drug dose of aza, pred, and csa, thereby minimizing clinical complications. the use of okt3 did not incr ... | 1985 | 2129408 |
| immunodetection of lipopolysaccharide in macrophages during the processing of non invasive shigella dysenteriae. | the location of lipopolysaccharide (lps) was studied by immunofluorescence and immunoelectron microscopy in macrophages infected with a non-invasive shigella dysenteriae 1 strain. bacterial degradation began only 3 h after the end of infection. the first visible sign of degradation was detected by immunogold labelling at the level of lps which detached from the bacterial surface and was transferred to the perinuclear lysosomes. after a few hours, it was found in small vesicles spread over the wh ... | 1990 | 2129020 |
| possible torsade in a patient with aids. | 1989 | 2115530 | |
| [experience in using new drug preparations for treating adult patients with acute intestinal infections]. | ciprofloxacin (bayer, frg), a derivative of hydroxyquinolone acid, was used for the treatment of patients with shigellosis and salmonellosis and for the sanitation of salmonella carriers. the drug turned out to exert a positive effect on bacteriological sanitation of the body. in order to treat patients with food toxinfection of unknown etiology, use was made of intetrix (farmacos, socialist federal republic of yugoslavia). inclusion of the drug into combined treatment of patients with food toxi ... | 1990 | 2110389 |
| improved sectioning and ultrastructure of bacteria and animal cells embedded in lowicryl. | lowicryl k4m-embedded gram-positive and gram-negative bacteria have a tendency to separate between the cell surface and the resin. this often leads to distortion of bacteria and more especially of mycobacteria. we describe attempts made to overcome this technical problem. different assays were made on bacillus subtilis, escherichia coli, and mycobacterium avium: 1) modification of the bacterial surface by coating of bacteria with proteinic compounds; 2) treatment of bacteria with metallic salts ... | 1990 | 2110246 |
| construction and evaluation of live attenuated vaccine strains of shigella flexneri and shigella dysenteriae 1. | shigellosis is an invasive disease of the human colon which is particularly prevalent among children of the developing world. no proper vaccine is available to protect against this enteric disease. it is currently accepted that only live strains with attenuated virulence administered orally may elicit protective immunity at the level of the colonic mucosa, which is the exclusive site of multiplication of causative microorganisms such as shigella flexneri and shigella dysenteriae 1. we have const ... | 1990 | 2101481 |
| multidrug resistant epidemic shigellosis in a village in west bengal, 1984. | an out break of acute bacillary dysentery in a village called dhamasin in hooghly district of west bengal was investigated during march 1984. forty seven percent of families were affected. a total of 91 cases and 2 deaths occurred amongst 937 people giving an over all attack rate of 9.7% and a case fatality rate of 2.2 percent. highest attack rate (22.7%) was observed in below one year age group. multiple drug resistant shigella dysentery type 1 strains were isolated for the first time from 6 ou ... | 1990 | 2101383 |
| outbreak of dysentery due to nalidixic acid resistant s. dysenteriae 1 at agartala, tripura: a hospital based study. | during the epidemic of bacillary dysentery at agartala, tripura, a total of 62 hospitalized patients suffering from diarrhoeal diseases were studied during the later part (11-16 june, 1988) of the epidemic. principal features of shigellosis cases were discussed. of these 62 cases investigated, 19(30.6%) cases had the mucoid diarrhoea. from them s.dysenteriae type 1 and s.flexneri had been recovered from 31.6% and 10.5% cases, respectively. all the strains of s.dysenteriae type 1 isolated during ... | 1990 | 2101382 |
| [derivative spectroscopy and its use in sanitary hygiene control]. | an analytical method is developed for defining the residual quantities of rodenticide "brodifacoum" (talon) used in the control of harmful field rodents and especially for species microtus. the method is based on extracting the pesticide with chloroform and making use of spectrophotometry in the ultraviolet field in intervals 340-240 nm. the second derivative of the absorption is utilized as well as the band with maximum 288 nm and minimum 228 nm. the peak height in this interval is in proportio ... | 2007 | 2099444 |
| [the characteristics of the biological properties of shigella dysenteriae 1 circulating in the ussr and india: its biochemical activity and agglutinability]. | the properties of 71 s. dysenteriae 1 strains isolated from patients in the ussr and india in 1986-1988 were studied. the cultures possessed typical biochemical and serological properties. as revealed in this investigation, high fastidiousness of this infective agent to the quality of synthetic nutrient could become the cause of false negative reactions in different substrates used for the identification of enterobacteria, thus leading to diagnostic mistakes. the variability of the biochemical a ... | 1990 | 2097846 |
| ["the profession is not the cause of the crisis"]. | 2006 | 2095089 | |
| [health economics--stopgap measures are no decisions. interview by kaj nyman]. | 2006 | 2095080 | |
| [identification of the public health nurse within the public health work force in the regional health department-6 of ribeirão preto, sp, (brazil)]. | the general purpose of this study was the identification of the nurse within the public health work force in the regional health department of ribeirão preto of the state health secretariat of s. paulo. a questionnaire the options of which included: identification, level of training, progress in career, function, future professional expectations and membership of professional associations, was the chief data source. of the group studies 35 were female, 40% of whom were between 20 and 39 years ol ... | 2003 | 2094953 |
| [emergency coronary surgery in patients with unstable angina pectoris. results and place in the total concept of the treatment of this group of patients]. | the urgent coronary surgery performed in patients with high risk unstable angina (rest pain greater than 48 h) shows still different results. we found in 57 urgent operated patients the same functional and clinical results as after elective bypass grafting. a higher in hospital mortality after urgent coronary surgery based on a higher number of grafts are occluded in the early postoperative period. the better prognosis concluded that the use of urgent coronary surgery is the therapy of choice in ... | 2002 | 2094888 |
| [aminoacyl-trna synthetases (codases) and their noncanonical functions]. | the aim of this review is to summarize the data obtained in the author's laboratory during the last decade. the main objects of these investigations were mammalian aminoacyl-trna synthetases, mainly bovine tryptophanyl-trna synthetase (ec 6.1.1.2). the data are discussed and compared with those described in literature. in the course of these studies it turned out that some properties of mammalian aminoacyl-trna synthetases for instance, nuclear location of some of the synthetases, presence of ex ... | 1990 | 2094804 |
| two unrelated cases of single maxillary central incisor with 7q terminal deletion. | two unrelated cases of single maxillary central incisor (sm-ci) with 7q terminal deletion of the same breakpoint at 7q36.1 were described. they had mental retardation, microcephaly, hypotelorism, short stature, and normal levels of plasma growth hormone. one case had bilateral caudal ectopic kidneys, double renal pelves, and dilated ureters. the other had bilateral hydroureteronephrosis. the present cases suggest that 7q terminal deletion is one of the causes of smci. | 1990 | 2094780 |
| the mechanism of inhibition of s-adenosyl-l-homocysteine hydrolase by fluorine-containing adenosine analogs. | (z)-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine (i), 5'-deoxy-5'-difluoroadenosine (ii), and 4',5'-didehydro-5'-deoxy-5'-fluoroarabinosyl-adenosine (iii) are inhibitors of rat liver s-adenosyl-l-homocysteine hydrolase. compounds i and ii are time-dependent and irreversible inhibitors of the enzyme. both i and ii are oxidized by e.nad to produce e.nadh, and fluoride anion is formed in the inactivation reaction (0.7 to 1.0 mole fluoride/mole of enzyme subunit, and 1.7 moles fluoride/mole of enzyme ... | 1990 | 2094766 |
| [effects of ethidium bromide on the viscosity of chromatin secreted by rat liver in normal state and after denervation]. | the paper studies structural state of chromatin secreted from the rat's liver. for this purpose the authors studied the dependence of relative viscosity of chromatin preparations secreted from the liver of rats and three groups of animals being in different terms of postdenervation process. | 1990 | 2083357 |
| [effect of maternal virus-specific t-lymphocytes on pregnancy and fetal pathogenesis in experimental congenital influenza infection]. | inoculation of virus-specific cytotoxic lymphocytes (ctl) to pregnant mice infected with influenza virus was shown to result in a decrease of infectious virus concentration in the lungs and blood of mice as well as in the placentas and fetuses. with an increase in the dose of inoculated ctl, however, premature deliveries with stillbirths were observed as well as deaths of the mice, the highest frequency of fetal deaths being observed after infection of pregnant mice in the first half of pregnanc ... | 1990 | 2082546 |
| [the visit of french military physicians to the ussr]. | 1955 | 2082543 | |
| shiga-like toxin and haemolytic-uraemia syndrome. | 1990 | 2080009 | |
| [the drug resistance and dna plasmid profiles of shigella dysenteriae 1 in the ussr and abroad]. | the medicinal resistance and plasmid profiles of 62 s. dysenteriae strains 1, isolated in the ussr in 1986-1988 from soviet and foreign citizens (from afghanistan, vietnam) and 8 strains obtained from india in 1987 were studied. pronounced similarity between the phenotypes of medicinal, including conjugative, resistance in the strains of soviet and foreign origin was established. in the soviet s. dysenteriae strains 1 the presence of two main types of plasmid dna profiles (140, 6, 4, 2 md and 14 ... | 1990 | 2075761 |
| [recurrent thromboembolism disclosing protein c deficiency. apropos of a case with familial investigation]. | every thromboembolic manifestation, especially in young subjects, calls for an aetiological study in which haemostasis is evaluated primarily with assays of physiological coagulation inhibitors: protein c, protein s and antithrombin iii. protein c deficiency is found in 6 to 7% of thromboembolic manifestations. we report the case of a 21-year old man who had phlebitis followed by pulmonary embolism without facilitating factors. protein c level was 50% of normal value (0.50 iu/ml). the patient re ... | 1990 | 2075365 |
| nonsquamous tumors of the head and neck in the geriatric population. | thyroid tumors, salivary gland tumors, and non-hodgkin's lymphoma are described. psychosocial issues involving the geriatric patient are discussed. case reports of a number of geriatric tumor patients are included. | 2007 | 2074986 |
| structural equation modeling in clinical assessment research with children. | the use of structural equation modeling has gained increased interest in recent years in the social and behavioral sciences. this article reviews the basic tenets of structural modeling in relation to issues in research and practice involving clinical assessment and compares this approach with more traditional psychometric approaches to the validation of assessment instruments with children. arguments for and against the inclusion of nonexperimental variables in causal studies aimed at establish ... | 1981 | 2071721 |
| [a provisional serovar of shigella dysenteriae isolated in japan from travellers' diarrhea]. | a bacterial strain was isolated that possessed the biochemical characteristics of shigella dysenteriae but did not belong to any of the established s. dysenteriae serovars, from the feces of a diarrheal case who had travelled to turkey, pakistan, india and thailand for about a month. this strain was invasive to tissue culture cells and gave a positive serény test. preparing antiserum against this strain and examining the antigenic relationship with the established o antigens of shigella and esch ... | 1991 | 2066600 |
| site-specific recombinase genes in three shigella subgroups and nucleotide sequences of a pinb gene and an invertible b segment from shigella boydii. | inversional switching systems in procaryotes are composed of an invertible dna segment and a site-specific recombinase gene adjacent to or contained in the segment. four related but functionally distinct systems have previously been characterized in detail: the salmonella typhimurium h segment-hin gene (h-hin), phage mu g-gin, phage p1 c-cin, and escherichia coli e14 p-pin. in this article we report the isolation and characterization of three new recombinase genes: pinb, pind, and defective pinf ... | 1991 | 2061288 |
| antimicrobial therapy for shigellosis. | in controlled clinical trials, which were first performed with use of the sulfonamides, antimicrobial agents have been shown to shorten the duration of symptoms and lessen the excretion of pathogens during episodes of shigellosis. not all antimicrobial agents that are active in vitro against shigella are effective in vivo, and efficacy of an agent can only be assessed by properly conducted clinical trials. resistance to both ampicillin and trimethoprim-sulfamethoxazole, the drugs of choice for t ... | 1991 | 2047659 |
| intestinal manifestations of invasive diarrheas and their diagnosis. | data from studies of 916 children with diarrhea, including 122 from whom shigellae were isolated, and data on patients affected in an epidemic due to shigella dysenteriae type i were analyzed to determine whether a diagnostic clinical profile of shigellosis could be identified. blood and/or mucus in stool, increased frequency of stool, abdominal pain, rectal tenesmus, and fever were noted more frequently in patients with shigellosis. the diagnostic confirmation of shigellosis depends on the isol ... | 1991 | 2047655 |
| shiga toxin: intestinal cell receptors and pathophysiology of enterotoxic effects. | shiga toxin is enterotoxic in rabbit small bowel and binds to the microvillus membrane (mvm). the toxin exhibits specificity for glycolipids possessing a terminal gal-alpha 1----4gal disaccharide, including the neutral glycolipid gb3 in mvm. gb3, which is developmentally regulated in the rabbit small bowel, is present in very low concentration until the animals reach day 16 of life. in older animals an increase in gb3 content is paralleled by an increase in the ability of mvm to bind toxin, whic ... | 1991 | 2047654 |
| digalactosyl-containing glycolipids as cell surface receptors for shiga toxin of shigella dysenteriae 1 and related cytotoxins of escherichia coli. | purified glycolipids containing galactose-alpha(1-4)galactose bind with shiga toxin of shigella dysenteriae 1 and shiga-like toxins of escherichia coli with high specificity in both thin-layer chromatograms and glycolipid-coated microtiter plates. these glycolipids appear to be the natural cell surface receptors for this class of bacterial toxins since artificial glycoconjugates block cytotoxicity as well as binding of 125i-labeled toxin. cell lines lacking these glycolipids are refractory to to ... | 1991 | 2047653 |
| shiga toxin: purification, structure, and function. | shiga toxin is a potent toxin produced by shigella dysenteriae type 1 strains. the toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. it consists of two polypeptide chains, an a chain (molecular weight, 32,225) and a b chain (molecular weight, 7,691). these two peptides associate with a stoichiometry of one a and five b subunits to form the holotoxin. the a chain is responsible for the biochemic ... | 1991 | 2047652 |
| mortality due to shigellosis: community and hospital data. | almost all fatal cases of shigellosis occur in developing countries, and data on mortality are generally compiled from three sources: investigations of epidemics caused by shigella dysenteriae type 1, surveillance of endemic diarrheal disease, and reports from hospitals. attack rates during epidemics of dysentery due to infection with s. dysenteriae type 1 have ranged from 1% to 33%, and case-fatality rates have ranged from 1% to 7%. in matlab, a rural district in bangladesh, most diarrhea-relat ... | 1991 | 2047645 |
| shigellosis in vietnam: seroepidemiologic studies with use of lipopolysaccharide antigens in enzyme immunoassays. | the performance of enzyme immunoassays (eias) with use of o-antigen-containing lipopolysaccharides (lpss) extracted with phenol-water from shigella dysenteriae type 1, shigella flexneri serotypes 1a-5b, and shigella sonnei for determination of the serum antibody responses after onset of bacillary dysentery is reviewed. for the purpose of several studies, serum samples from a total of 175 vietnamese and 47 swedish patients, for whom shigella species had been isolated from fecal specimens, were ob ... | 1991 | 2047643 |
| epidemiologic aspects of shigellosis and other causes of dysentery in thailand. | nearly 20% of children seen in the outpatient department of children's hospital in bangkok, thailand, for diarrheal disease had bloody diarrhea. shigella species and enteroinvasive escherichia coli--isolated from 13% and 2% of children with diarrhea, respectively--were the most frequent causes of bloody diarrhea. campylobacter species and nontyphoidal salmonella species were also isolated frequently but were much less often associated with bloody diarrhea. shigella species were rarely isolated f ... | 1991 | 2047642 |
| shigella dysenteriae type 1--guatemala, 1991. | on march 14, 1991, physicians at a hospital in guatemala city reported to the institute of nutrition of central america and panama (incap) that a 2-year-old boy living in an orphanage in guatemala city had been hospitalized with dysentery; stool cultures yielded shigella dysenteriae type 1. another child from the orphanage had recently died from dysentery. during march 18-21, two other young children from the orphanage were diagnosed with s. dysenteriae type 1. on march 21, health officials in r ... | 1991 | 2046650 |
| insulin and blood pressure regulation. | epidemiological evidence suggests that there is a close association between obesity, non-insulin-dependent diabetes (niddm) and hypertension. obesity and niddm are the classical insulin-resistant states. even in the absence of these conditions, essential hypertension is associated with insulin resistance. in view of the acute effects of insulin on renal sodium reabsorption, the sympathetic nervous system, the renin-angiotensin-aldosterone system, the transmembranous cation transport, the cardiov ... | 2007 | 2043223 |
| four decades of shigellosis in israel: epidemiology of a growing public health problem. | despite the improved standard of living in israel, shigellosis remains a common disease. examination of trends in the incidence of shigellosis in israel between 1951 and 1987 showed a period of declining rates followed by an increase in the reported incidence beginning around 1969. this increase was mainly due to shigella sonnei; rates of infection with shigella flexneri remained relatively constant. trends showed marked differences between age groups and between ethnic groups. in comparison, th ... | 1991 | 2041956 |
| when is treatment economically justified? | 1985 | 2041026 | |
| conversion of oral glucose to lactate in dogs. primary site and relative contribution to blood lactate. | we evaluated the relative contribution of oral glucose to arterial lactate and the relative role of the splanchnic bed in converting glucose to lactate in normal healthy dogs. after an oral glucose load (1.2 g/kg) spiked with [u-14c]glucose (16.9 muci/kg; protocol 1, n = 7), arterial blood lactate increased from 0.43 +/- 0.03 mm at basal to a peak of 1.04 +/- 0.07 mm at 45 min and then slowly decreased to 0.47 +/- 0.07 mm at 240 min. arterial blood [14c]lactate peaked at 60 min and then decrease ... | 1991 | 2040389 |
| the association of haemagglutination and adhesion with lipopolysaccharide of shigella dysenteriae serotype 1. | in this study the ability of strains of shigella dysenteriae serotype 1 to agglutinate mammalian erythrocytes is attributed to the polysaccharide fraction of bacterial-cell lipopolysaccharide (lps). lps obtained from a rough, mutant strain of s. dysenteriae serotype 1, lacking the o-antigen polysaccharide side-chain, did not agglutinate erythrocytes, clearly demonstrating a link between o-antigen polysaccharides and haemagglutinating activity (ha). strains of s. dysenteriae serotype 1 adhered we ... | 1991 | 2030501 |
| efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. | the aqueous extract of garlic (allium sativum) and allicin both showed significant in vitro antibacterial activity against isolates of multiple drug-resistant shigella dysenteriae 1, sh. flexneri y, sh. sonnei and enterotoxigenic escherichia coli. the minimum inhibitory concentrations of the aqueous extract and allicin against sh. flexneri y were 5 and 0.4 microliters/ml, respectively. the two agents also showed promising in vivo antibacterial activity against sh. flexneri y when tested in the r ... | 1991 | 2022399 |
| unusual association of a plasmid with nalidixic acid resistance in an epidemic strain of shigella dysenteriae type 1 from asia. | the association of a 20-mda plasmid with nalidixic acid resistant (nalr) strains of shigella dysenteriae 1 has been examined. the plasmid, which is readily transferable, does not itself code for nalidixic acid resistance but offers a survival advantage to its host under nalidixic acid stress. the plasmid-containing cultures of s. dynsenteriae 1 produced nalr mutants in vitro at a frequency 1000-fold higher than their plasmidless parent strains, after two exposures to nalidixic acid. using a simi ... | 1991 | 2021898 |