Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| gammaherpesvirus small noncoding rnas are bifunctional elements that regulate infection and contribute to virulence in vivo. | many viruses express noncoding rnas (ncrnas). the gammaherpesviruses (γhvs), including epstein-barr virus, kaposi's sarcoma-associated herpesvirus, and murine γhv68, each contain multiple ncrna genes, including micrornas (mirnas). while these ncrnas can regulate multiple host and viral processes in vitro, the genetic contribution of these rnas to infection and pathogenesis remains largely unknown. to study the functional contribution of these rnas to γhv infection, we have used γhv68, a small-an ... | 2015 | 25691585 |
| gold nano-particles (aunps) carrying anti-ebv-mir-bart7-3p inhibit growth of ebv-positive nasopharyngeal carcinoma. | epstein-barr virus (ebv) infection is a major etiological factor for nasopharyngeal carcinoma (npc). several ebv-encoded bart mirnas have been associated with viral latency, immune escape, cell survival, cell proliferation and apoptosis. here, we report that ebv-mir-bart7-3p, an ebv-encoded bart mirna highly expressed in npc, was correlated with cell-cycle progression in vitro and increased tumor formation in vivo. this viral mirna stimulated the pten/pi3k/akt pathway and induced c-myc and c-jun ... | 2015 | 25691053 |
| epstein-barr virus-negative hodgkin lymphoma presenting as haemophagocytic lymphohistiocytosis. | 2015 | 25691008 | |
| epstein-barr virus-associated post-transplantation lymphoproliferative disorder: potential treatments and implications for nursing practice. | considered to be a secondary malignancy, epstein-barr virus (ebv)-associated post-transplantation lymphoproliferative disorder (ptld) is a potentially fatal complication of hematopoietic cell transplantation (hct). with 50%-70% of all reported cases of ptld being associated with ebv, the incidence in hct is relatively low. however, mortality rates in this population of patients are 70%-90%. | 2015 | 25689655 |
| current preventive strategies and management of epstein-barr virus-related post-transplant lymphoproliferative disease in solid organ transplantation in europe. results of the esgich questionnaire-based cross-sectional survey. | there is limited clinical evidence on the utility of the monitoring of epstein-barr virus (ebv) dnaemia in the pre-emptive management of post-transplant lymphoproliferative disease (ptld) in solid organ transplant (sot) recipients. we investigated current preventive measures against ebv-related ptld through a web-based questionnaire sent to 669 sot programmes in 35 european countries. this study was performed on behalf of the esgich study group from the european society of clinical microbiology ... | 2015 | 25686696 |
| prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among japanese subjects. | the association between human cytomegalovirus (hcmv) and glioblastoma multiforme (gbm) is becoming a new concept. however, information on the geographic variability of hcmv prevalence in gbm remains scarce. moreover, the potential roles of various viruses, such as polyomaviruses and oncogenic viruses, in gliomagenesis remain unclear. our aim was to investigate the prevalence of hcmv in gbm among japanese patients. furthermore, this was the first study that evaluated infection with four new human ... | 2015 | 25685179 |
| angioimmunoblastic t-cell lymphoma: a diagnostic challenge. | angioimmunoblastic t-cell lymphoma (aitl) accounts for 15-20% of all peripheral t-cell lymphomas. it is a rare subtype of cd4 t-cell peripheral lymphoma that affects aged individuals, causing b symptoms, generalized lymphadenopathy and hepatosplenomegaly. its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. the majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first- ... | 2017 | 25685133 |
| human cytomegalovirus and epstein-barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. | to evaluate the best diagnostic technique and risk factors of the human cytomegalovirus (hcmv) and epstein-barr virus (ebv) infection in inflammatory bowel disease (ibd). | 2015 | 25684960 |
| macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis under treatment with tocilizumab. | to identify macrophage activation syndrome (mas) in patients with systemic juvenile idiopathic arthritis (sjia) undergoing tocilizumab (tcz) treatment, and to confirm laboratory marker changes and responses to treatment in patients with mas receiving tcz. | 2015 | 25684767 |
| rna: jack of all trades and master of all. | noncoding rnas have regulatory capabilities that evolution harnesses to fulfill diverse functions. lee et al. show that a noncoding rna from epstein-barr virus recruits a host transcription factor to silence virus gene expression and propose that it does this through base-pairing with nascent viral transcripts. | 2015 | 25679756 |
| primary lymphomas in the gastrointestinal tract. | primary gastrointestinal (gi) lymphomas are uncommon diseases that can involve the whole gi tract. the etiologies of the disease remain unclear, and potential risk factors include celiac disease, helicobacter pylori infection, use of immunosuppressive agents, human immunodeficiency virus (hiv) or epstein-barr virus (ebv) infection and inflammatory bowel disease, etc. diffuse large b-cell lymphoma (dlbcl) and mucosa-associated lymphoid tissue (malt) lymphoma are the most common subtypes of gi lym ... | 2015 | 25678011 |
| epstein-barr virus-induced polyclonal lymphoproliferative disorder of lymphoplasmacytic type in an autopsy case of aplastic anemia treated twice with anti-thymocyte globulin therapy. | 2015 | 25677466 | |
| cholestatic hepatitis induced by epstein-barr virus in a pediatric population. | we present 5 cases of epstein-barr virus (ebv)-induced cholestatic hepatitis (ch) and review all additional pediatric cases from the literature. | 2015 | 25676835 |
| primary natural killer/t cell lymphoma of the cervix: case report and clinicopathological analysis. | to present pathological and molecular characterizations of a rare case that was diagnosed as nasal-type natural killer (nk)/t cell lymphoma primarily arising in the cervix. | 2015 | 25675924 |
| lymphoepithelioma-like hepatocellular carcinoma: an uncommon variant of hepatocellular carcinoma with favorable outcome. | lymphoepithelioma-like hepatocellular carcinoma (lel-hcc) is an uncommon variant of hcc with only 22 cases reported in the literature. to better determine the incidence, clinicopathologic features, prognostic significance, and molecular pathogenesis of lel-hcc, we presented the largest series of lel-hcc from a 9-year retrospective cohort of patients with hcc undergoing surgical resection. lel-hcc was identified in 20 patients (4.9%). compared with patients having hcc without significant tumor-in ... | 2015 | 25675010 |
| hydrocephalus due to membranous obstruction of magendie's foramen. | we report a case of non communicating hydrocephalus due to membranous obstruction of magendie's foramen. a 37-year-old woman presented with intracranial hypertension symptoms caused by the occlusion of magendie's foramen by a membrane probably due to arachnoiditis. as far as the patient's past medical history is concerned, an epstein-barr virus infectious mononucleosis was described. fundoscopic examination revealed bilateral papilledema. brain magnetic resonance imaging demonstrated a significa ... | 2015 | 25674349 |
| nasopharyngeal carcinoma mimicking aspergillosis rhinosinusitis: an unusual case report and review of the literature. | clinical symptoms and imaging features of fungal infection are confused with those of atypical nasopharyngeal carcinoma (npc), and therefore development of a more effective diagnostic method is essential. it is a common knowledge that there is a significant association between epstein-barr virus (ebv) and nonkeratinizing npc. however, fungal infection may be considered to be a vital etiologic agent contributing to the npc and more evidence is needed to be approved this theory. we report on a rar ... | 2014 | 25674286 |
| clinicopathological study of sporadic burkitt lymphoma in children. | non-hodgkin lymphoma is the fourth most common malignant tumors in children, burkitt lymphoma (bl) accounts for 30-50% of all pediatric lymphomas. the aim of this study was to investigate the clinicopathologic features, immunophenotype, epstein-barr virus (ebv) infection and c-myc gene rearrangement of sporadic bl in children. | 2015 | 25673455 |
| epstein-barr virus vaccines. | epstein-barr virus (ebv) is the primary cause of infectious mononucleosis (im) and is associated with epithelial cell malignancies such as nasopharyngeal carcinoma and gastric carcinoma, as well as lymphoid malignancies including hodgkin lymphoma, burkitt lymphoma, non-hodgkin lymphoma and post-transplant lymphoproliferative disorder. ebv vaccines to prevent primary infection or disease, or therapeutic vaccines to treat ebv malignancies have not been licensed. most efforts to develop prophylacti ... | 2015 | 25671130 |
| rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology. | structural variants (svs) are less common than single nucleotide polymorphisms and indels in the population, but collectively account for a significant fraction of genetic polymorphism and diseases. base pair differences arising from svs are on a much higher order (>100 fold) than point mutations; however, none of the current detection methods are comprehensive, and currently available methodologies are incapable of providing sufficient resolution and unambiguous information across complex regio ... | 2014 | 25671094 |
| neuropilin 1 is an entry factor that promotes ebv infection of nasopharyngeal epithelial cells. | epstein-barr virus (ebv) is implicated as an aetiological factor in b lymphomas and nasopharyngeal carcinoma. the mechanisms of cell-free ebv infection of nasopharyngeal epithelial cells remain elusive. ebv glycoprotein b (gb) is the critical fusion protein for infection of both b and epithelial cells, and determines ebv susceptibility of non-b cells. here we show that neuropilin 1 (nrp1) directly interacts with ebv gb(23-431). either knockdown of nrp1 or pretreatment of ebv with soluble nrp1 su ... | 2015 | 25670642 |
| γ-herpesvirus load as surrogate marker of early death in hiv-1 lymphoma patients submitted to high dose chemotherapy and autologous peripheral blood stem cell transplantation. | autologous stem cell transplantation (asct) is a feasible procedure for human immunodeficiency virus-1 (hiv-1) lymphoma patients, whose underlying disease and intrinsic hiv-1- and asct-associated immunodeficiency might increase the risk for γ-herpesvirus load persistence and/or reactivation. we evaluated this hypothesis by investigating the levels of epstein-barr virus (ebv)- and kaposi sarcoma-associated herpesvirus (kshv)-dna levels in the peripheral blood of 22 hiv-1-associated lymphoma patie ... | 2015 | 25668032 |
| the beneficial effects of vitamin d3 on reducing antibody titers against epstein-barr virus in multiple sclerosis patients. | recently, the relationship between immunoreactivity to epstein-barr virus (ebv) and hypo-vitamin d in multiple sclerosis (ms) patients has been described. the aim of this study was to investigate whether vitamin d3 supplementation in ms patients could influence the immune response against latent ebv infection. forty ms patients were recruited in this study. twenty-seven patients were supplemented with 50,000 iu/week of vitamin d3 for 6 months and thirteen enrolled as controls. 25-hydroxyvitamin ... | 2015 | 25666504 |
| xiap deficiency syndrome in humans. | the x-linked inhibitor of apoptosis (xiap) deficiency, also known as the x-linked lymphoproliferative syndrome type 2 (xlp-2), is a rare primary immunodeficiency. xiap deficiency is characterized by a key triad of clinical manisfestations, which consist of a high susceptibility to develop hemophagocytic lymphohistiocytosis (hlh) frequently triggered by epstein-barr virus (ebv) infection, recurrent splenomegaly and inflammatory bowel disease (ibd) with the features of a crohn's disease. xiap defi ... | 2015 | 25666262 |
| peripheral t cell non-hodgkin's lymphoma following treatment of hodgkin's lymphoma. | previous reports have suggested that non-hodgkin's lymphoma (nhl) is more likely to develop in patients with hodgkin lymphoma (hl) compared to the general population. these two can occur synchronously or metachronously. we report here on a case of nodular sclerosis classical hl and t cell nhl that occurred in a patient metachronously. peripheral t cell lymphoma (ptcl) of the patient was found about 2 years after treatment of classical hl. when the patient was diagnosed with hl, biopsy revealed t ... | 2015 | 25664194 |
| environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. | the cause of multiple sclerosis is believed to involve environmental exposure and genetic susceptibility. we aimed to summarise the environmental risk factors that have been studied in relation to onset of multiple sclerosis, assess whether there is evidence for diverse biases in this literature, and identify risk factors without evidence of biases. | 2015 | 25662901 |
| ebv noncoding rna binds nascent rna to drive host pax5 to viral dna. | eber2 is an abundant nuclear noncoding rna expressed by the epstein-barr virus (ebv). probing its possible chromatin localization by chart revealed eber2's presence at the terminal repeats (trs) of the latent ebv genome, overlapping previously identified binding sites for the b cell transcription factor pax5. eber2 interacts with pax5 and is required for the localization of pax5 to the trs. eber2 knockdown phenocopies pax5 depletion in upregulating the expression of lmp2a/b and lmp1, genes neare ... | 2015 | 25662012 |
| early exposure to interleukin-21 limits rapidly generated anti-epstein-barr virus t-cell line differentiation. | the adoptive transfer of ex vivo-expanded epstein-barr virus (ebv)-specific t-cell lines is an attractive strategy to treat ebv-related neoplasms. current evidence suggests that for adoptive immunotherapy in general, clinical responses are superior if the transferred cells have not reached a late or terminal effector differentiation phenotype before infusion. the cytokine interleukin (il)-21 has shown great promise at limiting late t-cell differentiation in vitro, but this remains to be demonstr ... | 2015 | 25661862 |
| modification of cell differentiation, one of the mechanisms in the surveillance of malignancy. | most humans carry the potentially life-endangering epstein-barr virus (ebv). the immediate danger after infection is imposed by proliferation of the b cells that carry the viral genome. although a number of different cell types can be infected with ebv, b lymphocytes are exceptionally sensitive; they express a set of virus-encoded proteins, which collaborate with host proteins to induce proliferation. this phenomenon can be demonstrated in vitro with experimentally infected b cells. these viral ... | 2015 | 25660552 |
| management of extranodal natural killer/t-cell lymphoma, nasal type. | extranodal natural killer/t-cell lymphoma, nasal type (nktl) is an uncommon aggressive subtype of non-hodgkin lymphoma, which is significantly more common in east asia and latin america. three-quarters of patients present with stage i/ii disease, and half of patients have a low-risk international prognostic index score. although additional factors including natural killer/t-cell lymphoma prognostic index and peripheral blood epstein-barr virus load influence the outcomes, the modality of treatme ... | 2015 | 25659751 |
| the aetiology of pharyngotonsillitis in adolescents and adults - fusobacterium necrophorum is commonly found. | sore throat is common in primary healthcare. aetiological studies have focused on the presence of a limited number of pathogens. the aim of the present study was to investigate the presence of a wide range of bacteria and viruses, including fusobacterium necrophorum, in patients with pharyngotonsillitis and in asymptomatic controls. a prospective case control study was performed in primary healthcare in kronoberg county, sweden. patients (n=220) aged 15 to 45 years with a suspected acute pharyng ... | 2015 | 25658556 |
| polyclonal, newly derived t cells with low expression of inhibitory molecule pd-1 in tonsils define the phenotype of lymphocytes in children with periodic fever, aphtous stomatitis, pharyngitis and adenitis (pfapa) syndrome. | pfapa syndrome is a benign, recurrent inflammatory disease of childhood. tonsillectomy is one of the therapeutic options with a yet unexplained biological mechanism. we tested whether specific lymphocyte subsets recruited from blood to human tonsils participate in pfapa pathogenesis. | 2015 | 25656804 |
| post-transplant lymphoproliferative disorders. | post-transplant lymphoproliferative disorders (ptld) are a serious complication after solid organ or allogeneic hematopoietic stem cell transplantation and include a range of diseases from benign proliferations to malignant lymphomas. risk factors for developing ptld include epstein-barr virus (ebv) infection, recipient age, transplanted organ, type of immunosuppression, and genetics. uncontrolled proliferation of ebv-infected b cells is implicated in ebv-positive ptld, whereas the pathogenesis ... | 2015 | 25655616 |
| g-quadruplexes in pathogens: a common route to virulence control? | dna can form several secondary structures besides the classic double helix: one that has received much attention in recent years is the g-quadruplex (g4). this is a stable four-stranded structure formed by the stacking of quartets of guanine bases. recent work has convincingly shown that g4s can form in vivo as well as in vitro and can affect both replication and transcription of dna. they also play important roles at g-rich telomeres. now, a spate of exciting reports has begun to reveal roles f ... | 2015 | 25654363 |
| new approaches to treating b-cell cancers induced by epstein-barr virus. | 2015 | 25651254 | |
| development of a time-resolved fluorescence immunoassay for epstein-barr virus zta iga antibodies in human serum. | the epstein-barr virus (ebv) transactivator protein (zebra) is an immediate-early protein that plays an important role in the switch from latency to productive cycle in ebv virus. zebra is an important marker of ebv reactivation. in order to diagnose ebv infection status correctly and timely, a novel immunoassay was developed based on an indirect time-resolved fluoroimmunoassay (trfia) for zta iga, which used recombinant zta antigen as solid-phase antigen and eu(3+)-labeled mouse antihuman iga a ... | 2015 | 25651045 |
| cytokine profiles in mycoplasma pneumoniae infection-associated hemophagocytic lymphohistiocytosis. | a 3-year-old boy with mycoplasma pneumoniae infection associated with hemophagocytic lymphohistiocytosis (mp-hlh) presented with an elevated level of serum interleukin-12 (il-12) and lower levels of interferon-γ and il-10 compared to patients with epstein-barr virus infection associated with hlh (ebv-hlh). unlike the patients with ebv-hlh, cd8(+) cd5(low) hla-dr(++) t cells were not detected in our pediatric patient. thus, the pathophysiology of mp-hlh may differ from that of ebv-hlh. | 2016 | 25649486 |
| neo-clerodane diterpenoids from scutellaria barbata with activity against epstein-barr virus lytic replication. | bioassay-guided fractionation was conducted on an etoac-soluble extract of the whole plants of scutellaria barbata, monitored by inhibition of epstein-barr virus (ebv) lytic replication. twenty-six neo-clerodane diterpenoids were isolated, of which 13 are new (1-13, scutolides a-l) and 13 previously known (14-26). the structures of 1-13 were elucidated by analysis of their nmr and ms spectroscopic data. furthermore, the configurations of the new compounds 1 and 11 were confirmed by single-crysta ... | 2015 | 25647077 |
| cryoem and mutagenesis reveal that the smallest capsid protein cements and stabilizes kaposi's sarcoma-associated herpesvirus capsid. | with just one eighth the size of the major capsid protein (mcp), the smallest capsid protein (scp) of human tumor herpesviruses--kaposi's sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv)--is vital to capsid assembly, yet its mechanism of action is unknown. here, by cryoem of kshv at 6-å resolution, we show that scp forms a crown on each hexon and uses a kinked helix to cross-link neighboring mcp subunits. scp-null mutation decreased viral titer by 1,000 times and impaired but d ... | 2015 | 25646489 |
| hypersensitivity to influenza vaccine in a case of epstein-barr virus-associated t-lymphoproliferative disorder. | 2015 | 25645452 | |
| the b subunit of escherichia coli enterotoxin helps control the in vivo growth of solid tumors expressing the epstein-barr virus latent membrane protein 2a. | latent membrane protein 2a (lmp2a) is expressed on almost all epstein-barr virus (ebv)-associated tumors and is a potential target for immunotherapeutic intervention and vaccination. however, lmp2a is not efficiently processed and presented on major histocompatibility antigens class i molecules to generate potent cytotoxic t-lymphocytes (ctl) responses capable of killing these tumors. the b subunit of escherichia coli enterotoxin (etxb), causes rapid internalization and processing of membrane-bo ... | 2015 | 25641882 |
| epstein-barr virus oncoprotein super-enhancers control b cell growth. | super-enhancers are clusters of gene-regulatory sites bound by multiple transcription factors that govern cell transcription, development, phenotype, and oncogenesis. by examining epstein-barr virus (ebv)-transformed lymphoblastoid cell lines (lcls), we identified four ebv oncoproteins and five ebv-activated nf-κb subunits co-occupying ∼1,800 enhancer sites. of these, 187 had markedly higher and broader histone h3k27ac signals, characteristic of super-enhancers, and were designated "ebv super-en ... | 2015 | 25639793 |
| [helicobacter pylori -- 2014]. | the author reviews the main achievements in helicobacter pylori research in the past 2 years. of the more than 1000 micrornas described thus far, sets of over- and underexpressed samples were identified that are associated with either gastric cancer or precancerous lesions, and some of them could be either markers or therapeutic targets in the near future. meta-analyses involved 95 new publications: the association between infection and oesophageal, colorectal, pancreatic and liver carcinomas is ... | 2015 | 25639633 |
| recent advances in intestinal lymphomas. | a large variety of lymphoma types may develop as primary intestinal neoplasms in the small intestines or, less often, in the colorectum. among these are a few entities such as enteropathy-associated t-cell lymphoma or immunoproliferative small intestinal disease that, essentially, do not arise elsewhere than in the gastrointestinal tract. in most instances the primary intestinal lymphomas belong to entities that also occur in lymph nodes or other mucosal sites, and may show some peculiar feature ... | 2015 | 25639480 |
| study of adenovirus reproduction in different lymphoblastoid cell lines. | the comparative characteristic of the reproduction of adenovirus serotypes 2 and 5 (hadv-c2 and -c5) in the various lymphoblastoid cell lines were studied. rapid formation of infectious viruses in raji, mp-1, namalwa, bjab, mt4 and jurkat cells was marked and it was found to be close to the level of viruses during reproduction in permissive hep-2 epithelial cells. yield of infective adenovirus was low in b95-8 cells, which were chronically infected with epstein-barr virus (ebv). this may indicat ... | 2015 | 25639041 |
| [clinical and paraclinical features of syphilitic uveitis]. | syphilis, caused by treponema pallidum agent, results in polymorphic and non-specific ocular manifestations. early diagnosis and institution of individualized treatment play a large role in the prognosis. the increase in syphilis over the past several years requires the ophthalmologist to consider this diagnosis in the setting of any intraocular inflammatory involvement. | 2015 | 25637233 |
| detection of epstein-barr virus (ebv) in human lymphoma tissue by a novel microbial detection array. | infectious agents are estimated to play a causative role in approximately 20% of cancers worldwide. viruses, notably the epstein-barr virus (ebv), are associated with 10-15% of b-cell lymphomas and are found at a higher frequency in immunosuppressed patients. in this study, we screened human lymphoma tissues using a novel lawrence livermore microbial detection array (llmda), a comprehensive detection system that contains probes for all sequenced viruses and bacteria. this technology has been app ... | 2014 | 25635226 |
| deregulation of the cell cycle machinery by epstein-barr virus nuclear antigen 3c. | epstein-barr virus (ebv) is a ubiquitous human herpesvirus associated with a large number of lymphoid and epithelial malignancies. as a successful pathogen it has co-evolved with its human host for millions of years. ebv has the unique ability to establish life-long latent infection in primary human b lymphocytes. during latent infection, a small subset of viral proteins is expressed. these proteins are essential for maintenance of the ebv genome as well as the deregulation of various signaling ... | 2009 | 25635182 |
| t-cell receptor (tcr) phenotype of nodal epstein-barr virus (ebv)-positive cytotoxic t-cell lymphoma (ctl): a clinicopathologic study of 39 cases. | among epstein-barr virus (ebv)-positive cytotoxic t/nk-cell lymphoma, there are only a few reports on the clinicopathologic features of patients with primary nodal presentation (nodal ebv cytotoxic t-cell lymphoma [ctl]). here, we compared the clinicopathologic profiles of 39 patients with nodal ebv ctl with those of 27 cases of "extranasal" nk/t-cell lymphoma of nasal type (enktl), especially addressing their t-cell receptor (tcr) phenotype. histologically, 22 of 39 nodal ebv ctl cases (56%) we ... | 2015 | 25634749 |
| plasmablastic lymphoma of the stomach with c-myc rearrangement in an immunocompetent young adult: a case report. | plasmablastic lymphoma (pbl) is a rare b-cell neoplasm mostly described in human immunodeficiency virus-infected patients. herein, we described a case of pbl presenting as gastric mass in a 21-year-old young adult without known immunodeficiency. the histological examination of the specimen showed a diffuse proliferation of round- to oval-shaped large cells with scant cytoplasm, and prominent nucleoli. the neoplasm stained positively for cd45, cd38, mum1, and vs38c, but typical b-cell and t-cell ... | 2015 | 25634193 |
| update on epstein-barr virus and gastric cancer (review). | epstein-barr virus-associated gastric carcinoma (ebvagc) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. ebvagc is defined by monoclonal proliferation of carcinoma cells with latent ebv infection, as demonstrated by ebv-encoded small rna (eber) in situ hybridization. ebvagc has characteristic clinicopathological features, including predominance among males, a proximal location in the stomach, lymphoepithelioma-like histology and a favorable prognosis. ebvagc belongs to ... | 2015 | 25633561 |
| detection of the epstein-barr virus, human bocavirus and novel ki and ku polyomaviruses in adenotonsillar tissues. | we aimed to investigate the seasonal disturbations and the rates of detection of epstein-barr virus (ebv), human bocavirus (hbov), and polyomaviruses ki and wu (kipyv and wupyv) in adenoid and tonsil tissues during the absence of acute infection symptoms. | 2015 | 25631935 |
| epstein-barr virus lmp2a suppresses mhc class ii expression by regulating the b-cell transcription factors e47 and pu.1. | oncogenic epstein-barr virus (ebv) uses various approaches to escape host immune responses and persist in b cells. such persistent infections may provide the opportunity for this virus to initiate tumor formation. using ebv-immortalized lymphoblastoid cell lines (lcls) as a model, we found that the expression of major histocompatibility complex (mhc) class ii and cd74 in b cells is repressed after ebv infection. class ii transactivator (ciita) is the master regulator of mhc class ii-related gene ... | 2015 | 25631773 |
| treatment of plasmablastic lymphoma with multiple organ involvement. | we herein report the case of a 50-year-old woman who presented with persistent fever and a large mass in her right breast. haematology, liver function, and other blood test results were abnormal. computed tomography and positron emission tomography indicated that the lesion had spread to multiple organs. immunohistochemical staining confirmed that the patient had plasmablastic lymphoma, an invasive and rare form of diffuse large b-cell lymphoma, and an underlying infection by the epstein-barr vi ... | 2014 | 25630325 |
| intense pruritus in epstein-barr virus (ebv) hepatitis treated with naloxone drip. | pruritus is a manifestation of chronic liver disease. epstein-barr virus (ebv) infection often presents as infectious mononucleosis and mild hepatitis. severe pruritus in the setting of infectious mononucleosis and persistent marked hyperbilirubinaemia is exceedingly uncommon. to the best of our knowledge, we present the first case of a patient with ebv hepatitis and severe pruritus that was successfully treated with an ultra-low dose of intravenous naltraxone. | 2015 | 25628319 |
| novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. | the development of human induced pluripotent stem cell (ipsc) technology has revolutionized the regenerative medicine field. this technology provides a powerful tool for disease modeling and drug screening approaches. to circumvent the risk of random integration into the host genome caused by retroviruses, non-integrating reprogramming methods have been developed. however, these techniques are relatively inefficient or expensive. the mini-intronic plasmid (mip) is an alternative, robust transgen ... | 2015 | 25628230 |
| putative e3 ubiquitin ligase of human rotavirus inhibits nf-κb activation by using molecular mimicry to target β-trcp. | nf-κb plays a critical role in the induction and maintenance of innate and adaptive immune transcriptional programs. an associated inhibitor of κb protein (iκb) regulates nf-κb activation and contains a degron motif (dsgφxs) that undergoes phosphorylation following pathogen recognition or other proinflammatory signals. the e3 ubiquitin ligase scf(β-trcp) recognizes this phosphodegron through its β-transducin repeat-containing protein (β-trcp) subunit and induces iκb degradation, allowing nf-κb t ... | 2015 | 25626907 |
| frequency of epstein-barr virus dna sequences in human gliomas. | the epstein-barr virus (ebv) is the most common cause of infectious mononucleosis and is also associated with several human tumors, including burkitt's lymphoma, hodgkin's lymphoma, some cases of gastric carcinoma and nasopharyngeal carcinoma, among other neoplasms. the aim of this study was to screen 75 primary gliomas for the presence of specific ebv dna sequences by means of the polymerase chain reaction (pcr), with confirmation by direct sequencing. | 2015 | 25626853 |
| genipin as a novel chemical activator of ebv lytic cycle. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. ebv causes several human cancers, including burkitt's lymphoma, nasopharyngeal and gastric carcinoma. antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. most antiviral agents affect actively replicating viruses, but not their latent forms. novel antiviral agents must be active on both the replicating and the latent forms ... | 2015 | 25626372 |
| egcg inhibits proliferation, invasiveness and tumor growth by up-regulation of adhesion molecules, suppression of gelatinases activity, and induction of apoptosis in nasopharyngeal carcinoma cells. | (-)-epigallocatechin-3-gallate (egcg), a major green tea polyphenol, has been shown to inhibit the proliferation of a variety of tumor cells. epidemiological studies have shown that drinking green tea can reduce the incidence of nasopharyngeal carcinoma (npc), yet the underlying mechanism is not well understood. in this study, the inhibitory effect of egcg was tested on a set of epstein barr virus-negative and -positive npc cell lines. treatment with egcg inhibited the proliferation of npc cells ... | 2015 | 25625511 |
| primary lymphoepithelial carcinoma of the intraoral minor salivary gland: a case report. | lymphoepithelial carcinoma (lec) of salivary gland origin is a rare malignant tumor with morphological characteristics identical to those of undifferentiated nasopharyngeal carcinoma. it has a marked racial predilection for inuit and southeast asian populations. an association between lec and epstein-barr virus (ebv) infection has previously been reported. lec most frequently affects the parotid gland, followed by the submandibular glands. to the best of our knowledge, only three lecs arising fr ... | 2015 | 25624903 |
| pan-viral-microrna screening identifies interferon inhibition as a common function of diverse viruses. | diverse viruses encode regulatory rnas called micrornas (mirnas). despite much progress, the functions of the majority of viral mirnas remain unknown. most previous studies have used biochemical methods to uncover targets of viral mirnas, but it is unclear what fraction of these targets is functionally important. here, we apply an alternative strategy based on the premise that assorted viral mirnas will share functionality. screening a library of >70 human viral mirnas showed that three unrelate ... | 2015 | 25624489 |
| cutaneous epstein-barr virus-associated lymphoproliferative polymorphic disease - aids presenting manifestation. | 2016 | 25623621 | |
| an adolescent girl with crohn's disease, fever, and sore throat. | an adolescent female with a past medical history significant for crohn's disease presented with fevers, tonsillitis without exudate, and tender posterior cervical lymphadenopathy. laboratory results showed transaminitis, leukocytosis with a left shift, and atypical lymphocytes on a blood smear. the patient did not respond to supportive care or dexamethasone, necessitating a tonsillectomy and adenoidectomy. although her presentation was consistent with infectious mononucleosis, diagnosis was not ... | 2015 | 25621629 |
| cordycepin is a novel chemical suppressor of epstein-barr virus replication. | cordyceps species are known to produce numerous active components and are used for diverse medicinal purposes because of their varied physiological activities, including their ability to protect the liver from damage as well as their anticancer, antidepressant, anti-inflammatory, hypoglycemic, antimicrobial effects. cordycepin, an adenosine derivative, differs from adenosine in that its ribose lacks an oxygen atom at the 3' position. several research groups have reported that cordycepin has anti ... | 2014 | 25621301 |
| epstein -barr virus association with malignant lymphoma subgroups in zaria, nigeria. | epstein-barr virus (ebv) is said to infect more than 90% of humans worldwide with latent infection for life. a recognized carcinogen, ebv is linked to malignant lymphoma (ml) subtypes of burkitt's lymphoma (bl), plasmablastic lymphoma, diffuse large cell lymphoma (dlbcl) and hodgkin's lymphoma (hl). we report the association of ebv with ml in a segment of our patient population. paraffin blocks from the archives of abuth, zaria were used to construct tissue microarray sections stained using 30 m ... | 2017 | 25620871 |
| il-35 and autoimmunity: a comprehensive perspective. | interleukin 35 (il-35) is the most recently identified member of the il-12 family of cytokines and offers the potential to be a target for new therapies for autoimmune, inflammatory, and infectious diseases. similar to other members of the il-12 family including il-12, il-23, and il-27, il-35 is composed of a heterodimer of α and β chains, which in the case of il-35 are the p35 and epstein-barr virus-induced gene 3 (ebi3) proteins. however, unlike its proinflammatory relatives, il-35 has immunos ... | 2015 | 25619872 |
| exposure to neighborhood immigrant concentration from adolescence to young adulthood and immune function among latino young adults. | the immune system plays a critical role in the prevention of infectious and chronic disease. we investigate associations between exposure to neighborhood immigrant concentration across the transition from adolescence to adulthood and immune function among latino young adults, including moderation by nativity. data from the national longitudinal study of adolescent health (1994-2008) were analyzed. immune function was measured via epstein-barr virus (ebv) antibody levels (higher levels indicate i ... | 2015 | 25618565 |
| fatal autoimmune hemolytic anemia due to immunoglobulin g autoantibody exacerbated by epstein-barr virus. | most cases of autoimmune hemolytic anemia (aiha) are caused by the production of an autoantibody that targets determinants on red blood cells (rbcs). this autoantibody can be immunoglobulin (ig) g, igm, or iga. some autoantibodies react optimally at 0° to 4°c (ie, cold agglutinin) and usually are clinically insignificant. high-titer cold agglutinins are associated with igm autoantibody and complement fixation induced by infectious agents, including the epstein-barr virus (ebv). this case report ... | 2015 | 25617394 |
| a large-scale seroprevalence of epstein-barr virus in taiwan. | epstein-barr virus (ebv) causes a variety of clinical manifestations from asymptomatic infection to acute infectious mononucleosis in human. moreover, the ebv infection is associated with malignancies. the large-scale ebv seroepidemiology across all age groups has been lacking in taiwan. | 2015 | 25615611 |
| epstein barr virus-associated lymphoproliferative diseases: the virus as a therapeutic target. | epstein barr virus (ebv)-associated lymphoproliferative diseases (lpds) express all ebv latent antigens (type iii latency) in immunodeficient patients and limited antigens (type i and ii latencies) in immunocompetent patients. post-transplantation lymphoproliferative disease (ptld) is the prototype exhibiting type iii ebv latency. although ebv antigens are highly immunogenic, ptld cell proliferation remains unchecked because of the underlying immunosuppression. the restoration of anti-ebv immuni ... | 2015 | 25613733 |
| modeling ebv infection and pathogenesis in new-generation humanized mice. | the development of highly immunodeficient mouse strains has allowed the reconstitution of functional human immune system components in mice. new-generation humanized mice generated in this manner have been extensively used for modeling viral infections that are exclusively human tropic. epstein-barr virus (ebv)-infected humanized mice reproduce cardinal features of ebv-associated b-cell lymphoproliferative disease and ebv-associated hemophagocytic lymphohistiocytosis (hlh). erosive arthritis mor ... | 2015 | 25613732 |
| genomic assays for epstein-barr virus-positive gastric adenocarcinoma. | a small set of gastric adenocarcinomas (9%) harbor epstein-barr virus (ebv) dna within malignant cells, and the virus is not an innocent bystander but rather is intimately linked to pathogenesis and tumor maintenance. evidence comes from unique genomic features of host dna, mrna, microrna and cpg methylation profiles as revealed by recent comprehensive genomic analysis by the cancer genome atlas network. their data show that gastric cancer is not one disease but rather comprises four major class ... | 2015 | 25613731 |
| epstein-barr virus-positive t/nk-cell lymphoproliferative disorders. | epstein-barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in a variety of human diseases, including lymphoproliferative disorders. the oncogenic potential of epstein-barr virus is related to its ability to infect and transform b lymphocytes into continuously proliferating lymphoblastoid cells. however, epstein-barr virus has also been implicated in the development of t/natural killer cell lymphoproliferative diseases. epstein-barr virus encodes a ... | 2015 | 25613730 |
| ebv-driven b-cell lymphoproliferative disorders: from biology, classification and differential diagnosis to clinical management. | epstein-barr virus (ebv) is a ubiquitous herpesvirus, affecting >90% of the adult population. ebv targets b-lymphocytes and achieves latent infection in a circular episomal form. different latency patterns are recognized based on latent gene expression pattern. latent membrane protein-1 (lmp-1) mimics cd40 and, when self-aggregated, provides a proliferation signal via activating the nuclear factor-kappa b, janus kinase/signal transducer and activator of transcription, phosphoinositide 3-kinase/a ... | 2015 | 25613729 |
| epstein-barr virus latent genes. | latent epstein-barr virus (ebv) infection has a substantial role in causing many human disorders. the persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that ebv latent genes are important for malignant cell growth. while the ebv-encoded nuclear antigen-1 (ebna-1) and latent membrane protein-2a (lmp-2a) are critical, the ebna-leader proteins, ebna-2, ebna-3a, ebna-3c and lmp-1, are individually essential for i ... | 2015 | 25613728 |
| the regular distribution and expression pattern of immunosuppressive cytokine il-35 in mouse uterus during early pregnancy. | cytokines within the uterus are critical in the maternal-fetal immune regulation. immunosuppressive cytokine il-35 was recently discovered inhibitory cytokine, which were pivotal in the establishment of immune tolerance against self-antigens and antigens encountered in foreign implantation. in order to analyze the role of il-35 in maternal-fetal immune tolerance, the expression patterns of il-35 in mouse endometrium were studied during early pregnancy by immunohistochemistry, elisa and quantitat ... | 2014 | 25611266 |
| primary hepatic lymphoma in a patient with rheumatoid arthritis treated with methotrexate. | primary hepatic lymphoma (phl) has rarely been reported in patients with immunosuppression. we herein describe a case of epstein-barr virus- (ebv-) positive phl in a 67-year-old japanese woman receiving methotrexate (mtx) treatment for rheumatoid arthritis (ra). the patient, who had been receiving mtx therapy for more than 6 years, presented with low-grade fever and abdominal pain. initial laboratory tests showed mildly elevated liver enzymes with normal levels of alpha-fetoprotein and carcinoem ... | 2014 | 25610674 |
| mycophenolate mofetil in the treatment of systemic lupus erythematosus. | mycophenolate mofetil (mmf) is an immunosuppressive agent that has been shown to be effective in transplant patients. it is also efficacious in the management of lupus nephritis and useful in the treatment of autoimmune conditions because its mechanisms of action target t- and b- lymphocytes, leading to suppression of the cell-mediated immune response and antibody formation. mmf has been used successfully to treat immune-mediated conditions like myasthenia gravis, autoimmune hepatitis and immune ... | 2009 | 25610099 |
| follicular variant of peripheral t cell lymphoma with mediastinal involvement in a child: a case report. | peripheral t cell lymphomas are rare in young patients. we report the first case of a follicular variant of peripheral t cell lymphoma not otherwise specified in an 11-year-old boy, who presented with a large mediastinal mass. microscopic examination of the mediastinal biopsy revealed nodular infiltration of medium- to large-sized atypical lymphocytes. immunohistochemistry showed expression of follicular helper t cell markers (cd10, pd1, cxcl13, and bcl6) in tumor t cells. epstein-barr virus (eb ... | 2015 | 25604350 |
| an epigenetic view of b-cell disorders. | b-cell development is a multistep process sustained by a highly coordinated transcriptional network under the control of a limited set of transcription factors. epigenetic mechanisms, including dna methylation, histone posttranslational modifications and micrornas act in concert with transcription factors to promote lineage commitment, define and sustain cell identity and establish heritable cell-type- and stage-specific gene expression profiles. epigenetic modifiers have recently emerged as key ... | 2015 | 25601271 |
| twenty-first-century oral hairy leukoplakia--a non-hiv-associated entity. | this study presents the clinicopathologic features of a series (n = 35) of patients with non-human immunodeficiency virus (hiv)-associated oral hairy leukoplakia (ohl). | 2015 | 25600979 |
| epstein-barr virus-positive diffuse large b-cell primary central nervous system lymphoma associated with organized chronic subdural hematoma: a case report and review of the literature. | we here report on a rare case of epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) detected in both brain parenchyma and in an organized chronic subdural hematoma (ocsh). a 96-year-old man diagnosed with asymptomatic ocsh in the left frontal convexity was referred to our hospital because of a de novo mass lesion just beneath the ocsh on contrast-enhanced magnetic resonance imaging. the size of the ocsh remained stable. we diagnosed the lesion as a malignant tumor. at surger ... | 2015 | 25597523 |
| role of human natural killer cells during epstein-barr virus infection. | human natural killer (nk) cells have been suggested to restrict viral infections. however, the evidence for this notion is mostly circumstantial. recent studies in mice with reconstituted human immune system components, children with symptomatic primary epstein-barr virus (ebv) infection, and in secondary lymphoid tissues of healthy ebv carriers have, however, shown that early differentiated human nk cells limit lytic ebv replication and thereby prevent the immunopathological expansion of lytic ... | 2014 | 25597312 |
| cyclin d1-positive diffuse large b-cell lymphoma with igh-ccnd1 translocation and bcl6 rearrangement: a report of two cases. | to demonstrate and confirm the existence of cyclin d1-positive diffuse large b-cell lymphoma (dlbcl) with igh-ccnd1 rearrangement and discuss the rationale of differentiating this entity from blastoid and pleomorphic variants of mantle cell lymphoma (mcl). | 2015 | 25596256 |
| thyroid carcinoma showing thymus-like elements: a clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis. | to investigate the clinicopathologic, immunophenotypic, ultrastructural, and molecular features of thyroid carcinoma showing thymus-like elements (castle). | 2015 | 25596248 |
| ebv, the human host, and the 7tm receptors: defense or offense? | being present in around 90% of the worldwide population, epstein-barr virus (ebv) is an exceptionally prevalent virus. this highly successful virus establishes a latent infection in resting memory b cells and is maintained in a balance between viral homeostasis on one side and antiviral defense of the immune system on the other side. the life cycle of ebv is dependent on many viral proteins, but ebv also regulates a number of endogenous proteins. 7tm receptors and ligands of viral and host origi ... | 2015 | 25595811 |
| lymphoepithelioma-like carcinoma: a distinct type of gastric cancer. | lymphoepithelioma-like carcinoma (lelc) is a rare type of gastric carcinoma and has histologic features of intense lymphocytic infiltration. in this study, we attempted to analyze the clinicopathologic characteristics and survival outcome of patients with lelc compared with those with non-lymphoepithelioma-like carcinoma (nlelc). | 2015 | 25592274 |
| diphenylene iodonium interferes with cell cycle progression and induces apoptosis by modulating nad(p)h oxidase/ros/cell cycle regulatory pathways in burkitt's lymphoma cells. | infection with epstein-barr virus (ebv) and its encoded latent membrane protein 1 (lmp1) play oncogenic roles in burkitt's lymphoma (bl). flow cytometry was used to measure cellular reactive oxygen species (ros) concentrations, and cellular lactate generation and diphenylene iodonium (dpi) cytotoxicity were determined by analyzing lactate concentrations and cell viability. we also measured nad(p)h oxidase (nox) activity. reverse transcriptase pcr and qpcr assays were used to analyze lmp1 levels, ... | 2015 | 25591797 |
| the epstein-barr virus encoded bart mirnas potentiate tumor growth in vivo. | the human herpes virus epstein-barr virus (ebv) latently infects and drives the proliferation of b lymphocytes in vitro and is associated with several forms of lymphoma and carcinoma in vivo. the virus encodes ~30 mirnas in the bart region, the function of most of which remains elusive. here we have used a new mouse xenograft model of ebv driven carcinomagenesis to demonstrate that the bart mirnas potentiate tumor growth and development in vivo. no effect was seen on invasion or metastasis, and ... | 2015 | 25590614 |
| [cutaneous lymphomas: new entities and rare variants]. | primary cutaneous lymphomas are the second most common group of extranodal non-hodgkin lymphomas. recently several new variants and entities have been described but have not yet become part of the world health organization (who) classification. these forms include the granulomatous form of mycosis fungoides, which is associated with a poorer prognosis, as well as indolent cd8+ lymphoproliferations on the head and at acral localizations. within the group of cutaneous cd30+ lymphoproliferative dis ... | 2015 | 25589355 |
| cytotoxic, antitumour-promoting and inhibition of protein denaturation effects of flavonoids, isolated from potentilla evestita th. wolf. | this study was designed to evaluate the isolated flavonoids (chrysin 1, and umbelliferone 2) from potentilla evestita for cytotoxic, antitumour-promoting and inhibition of protein denaturation activities. the results showed marked cytotoxic effect of compounds 1 and 2 in brine shrimp cytotoxic assay at various concentrations with ld50 of 34.5 and 31.8 mg/ml, respectively. in epstein-barr-virus early antigen activation assay, both compounds 1 and 2 illustrated significant antitumour-promoting eff ... | 2015 | 25588733 |
| a case of type ii enteropathy-associated t-cell lymphoma with epstein-barr virus positivity. | 2014 | 25588633 | |
| early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice. | there is an urgent need for preclinical models of prostate cancer; however, clinically relevant patient-derived prostate cancer xenografts (pdxs) are demanding to establish. | 2015 | 25585936 |
| viral infections in acute graft-versus-host disease: a review of diagnostic and therapeutic approaches. | while immunosuppressive therapy for acute graft-versus-host disease (agvhd) advances, viral reactivation has been found to be an increasingly common complication in these patients. dermatologists may often be consulted on inpatient services for evaluation. | 2015 | 25582535 |
| impact of epstein barr virus-related complications after high-risk allo-sct in the era of pre-emptive rituximab. | we monitored 133 high-risk allo-sct recipients for 6 months after transplant for ebv reactivation by quantitative real-time pcr. rituximab was given as pre-emptive therapy for viremia >1000 copies/ml. the 1-year cumulative incidence of ebv reactivation was 29.4% (95% confidence interval (ci): 18-40) in patients monitored due to initial high-risk characteristics (n=93) and 31.8% (95% ci: 19.7-44) in those followed because of the development of refractory gvhd (n=40). overall response rate to ritu ... | 2015 | 25581404 |
| [macrophage activation syndrome in a patient with systemic juvenile idiopathic arthritis]. | machrophage activation syndrome (mas) is a rare and potentially fatal disease, commonly associated with chronic rheumatic diseases, mainly juvenile idiopathic arthritis. it is included in the group of secondary forms of haemophagocytic syndrome, and other causes are lymphoproliferative diseases and infections. its most important clinical and laboratorial manifestations are non-remitting fever, splenomegaly, bleeding, impairment of liver function, cytopenias, hypoalbuminemia, hypertriglyceridemia ... | 2017 | 25575650 |
| [il-35 level of peripheral blood is correlated with the immune response to hepatitis b vaccine]. | to investigate the relationship of il-35 level in peripheral blood mononuclear cells (pbmcs) and immune response to hepatitis b vaccine and explore the factors influencing vaccine immune reaction. | 2015 | 25575066 |
| total synthesis of plagiochin g and derivatives as potential cancer chemopreventive agents. | a new and efficient total synthesis has been developed to obtain plagiochin g (22), a macrocyclic bisbibenzyl, and four derivatives. the key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular snar reaction. all synthesized macrocyclic bisbibenzyls inhibited epstein-barr virus early antigen (ebvea) activation induced by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (tpa) in raji cells and, thus, are potential cancer chemopreventive agents. | 2014 | 25574060 |
| [clinical outcomes of allogeneic hematopoietic stem cell transplantation patients with co-activation of cytomegalovirus and epstein-barr virus]. | to evaluate the impact of cytomegalovirus (cmv) and epstein-barr virus (ebv) co-activation on the prognosis of allogeneic hematopoietic stem cell transplantation (allo-hsct) patients. | 2014 | 25573307 |