Publications

current concepts in therapy: the treatment of acne with antibiotics.		1973	4267707
quantitation of corynebacterium acnes on healthy human skin.		1973	4266932
incidence and lipolytic activity of propionibacterium acnes (corynebacterium acnes group i) and p. granulosum (c. acnes group ii) in acne and in normal skin.		1973	4266325
microbiology of comedones in acne vulgaris.		1973	4266324
acne vulgaris. oral therapy with tetracycline and topical therapy with vitamin a.		1972	4261761
is sulphur helpful or harmful in acne vulgaris?		1972	4261597
the effect of clindamycin in acne--a clinical and laboratory investigation.		1972	4261368
individual and site variation in composition of facial surface lipids.		1972	4260565
[immunological response to bacterial antigens in acne vulgaris].		1972	4258868
partial purification and some properties of a lipase from corynebacterium acnes.		1971	4258517
the production of hyaluronidase (hyaluronate lyase) by corynebacterium acnes.		1972	4258461
inhibition of corynebacterium acnes lipase by tetracycline.		1971	4253992
tetracycline inhibition of a lipase from corynebacterium acnes.	a lipase which hydrolyzes triglycerides (tricaprylin and trilaurin) and naphthyl laurate was obtained from the broth of corynebacterium acnes cultures by ammonium sulfate fractionation. ca(2+) and sodium taurocholate stimulated activity of the enzyme. ethylenediaminetetraacetic acid (edta) did not inhibit activity of the ca(2+)-activated enzyme, but lipolytic activity was inhibited by edta in the absence of ca(2+). tetracycline (10(-4)m) produced a slight inhibition of the lipase activity with 5 ...	1971	4252558
fine structure of corynebacterium acnes.		1970	4245203
acne vulgaris. studies in pathogenesis: triglyceride hydrolysis by corynebacterium acnes in vitro.		1970	4244560
acne vulgaris. studies in pathogenesis: fatty acids of corynebacterium acnes.		1970	4244368
[antibiotic sensitivity of corynebacterium acnes].		1969	4241502
the localization and distribution of corynebacterium acnes and its antigens in normal skin and in lesions of acne vulgaris.		1969	4240957
the possible relationship of corynebacterium acnes (propionibacterium acnes) to the pathogenesis of acne vulgaris.		1969	4239363
identification of corynebacterium acnes.		1968	4231056
characterization of corynebacterium acnes.		1968	4230359
red fluorescence of comedones: production of porphyrins by corynebacterium acnes.		1967	4228644
dermal hypersensitivity of patients with acne vulgaris to corynebacterium acnes.		1967	4227025
corynebacterium acnes. presence of complement fixing antibodies to corynebacterium acnes in the sera of patients with acne vulgaris.		1966	4222469
hydrosoluble immunopotentiating substances extraced from corynebacterium parvum.		1974	4217774
a technique for sampling micro-organisms from the pilo-sebaceous ducts.		1974	4213708
corynebacterium parvum as a therapeutic antitumor agent in mice. ii. local injection.		1974	4213016
corynebacterium parvum as a therapeutic antitumor agent in mice. i. systemic effects from intravenous injection.		1974	4213015
potential antileprotic agents. 3. inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines.		1974	4209923
immunostimulation with bacterial phospholipid extracts.	injection of bacterial phospholipid extracts (ebp) into mice increased their resistance towards a listeria monocytogenes infection. the blood clearance of virulent salmonella typhimurium was enhanced and the degree of clearance correlated with the dose of extract injected. the multiplication of listeria monocytogenes in spleen and liver of mice was inhibited and this inhibition was also correlated with the amount of extract injected. the absence of apparent toxicity in mice, of splenoand hepatom ...	1974	4205595
[inhibitory action of corynebacterium parvum on the development of malignant syngenic tumors, and its mechanism].		1973	4201539
immunology in cutaneous leishmaniasis.		1973	4200332
role of anaerobic coryneforms in specific and non-specific immunological reactions. ii. production of a chemotactic factor specific for macrophages.		1973	4197975
enhancement and depression of the antibody response in mice caused by corynebacterium parvum.		1974	4157122
[investigations of the serological relationship between actinomyces israelii and corynebacterium acnes (author's transl)].		1974	4151213
[bacteriophages of propionibacterium acnes (author's transl)].		1973	4150070
the growth of tumours in t-cell deprived mice and their response to treatment with corynebacterium parvum.		1973	4147951
an experimental screening for "systemic adjuvants of immunity" applicable in cancer immunotherapy.		1973	4146853
letter: methyl-cholanthrene-induced sarcomata in mice after immunisation with corynebacterium parvum plus syngeneic subcellular membrane fractions.		1974	4143365
effects of corynebacterium parvum and freund's adjuvants on amphibian antibody responses.		1974	4142047
properties of an antigenic polysaccharide from corynebacterium parvum.	corynebacterium parvum strain 10390 is an antitumor agent and stimulant of the reticuloendothelial system and produces a soluble antigen towards the end of its growth cycle. this material, which is a cell wall component and can also be released from the organism by acid or alkaline hydrolysis, has been purified. it is an acidic polysaccharide of molecular weight 100,000 to 150,000 and contains galactose, glucose, fucose, n-acetylgalactosamine, n-acetylglucosamine, uronic acids, sialic acids, and ...	1974	4138438
identification of actinomyces, arachnia, bacterionema, rothia, and propionibacterium species by defined immunofluorescence.	fractionated fluorescein-isothiocyanate (fitc)-conjugated immunoglobulin g (dye-to-protein ratio <10), produced against whole cells of actinomyces spp., arachnia, bacterionena, rothia, and propionibacterium spp., give species-specific conjugates with controlled nonspecific staining reactions when appropriately diluted on the basis of their antibody content (10 mg/ml). using this standardization in immunofluorescence, serotype-specific conjugates are also available after dilution for all serotype ...	1973	4123707
effect of adjuvants on the antibody response to a hapten on a thymus-independent carrier.		1972	4115393
tetracycline-resistant staphylococci in acne vulgaris.		1972	4111110
nine-year microflora study of an isolator-maintained immunodeficient child.	a male child, maintained in a controlled environment, was monitored each month for bacteria, yeasts, and filamentous fungi recovered from the mouth, nasal passages, feces, and nine body surface sites. three natural microbial categories became apparent. incident microorganisms were recovered from within the isolator but did not establish permanent residence. of the 53 incident types isolated, 20 were filamentous fungi and 4 were yeasts. some genera, such as fusobacterium, lactobacillus, neisseria ...	1985	4091564
a toxin released from variant strains of propionibacterium acnes isolated from patients with kawasaki disease.		1985	4087873
biological activities of chemically synthesized partial structure analogues of lipid a.	analogues of the nonreducing sugar part of lipid a were chemically synthesized and tested for biological activities such as limulus amebocyte lysate gelation, interferon- and tumor necrosis factor-induction, lethal toxicity in galactosamine-sensitized mice, and pyrogenicity. a 4-o-monophosphorylglucosamine derivative possessing 2-n-3-tetradecanoyl-oxytetradecanoyl and 3-o-tetradecanoyl groups (gla-27) exhibited all activities tested except for pyrogenicity. alteration of the acyl substituents or ...	1985	4086478
purification and properties of a proline iminopeptidase from propionibacterium acnes.	proline iminopeptidase was extracted from the cells of a strain of propionibacterium acnes and purified. the molecular weight was estimated to be about 120,000 by sds-polyacrylamide gel electrophoresis. the enzyme showed the highest activity at 50 degrees c-55 degrees c and its optimum ph was found at 7.5-8.0. the enzyme activity was inhibited by p-chloromercuribenzoate, indicating that this peptidase is a sh-enzyme. especially prolyl-glycyl-glycine but also prolyl-proline bonds were hydrolyzed ...	1985	4082822
mouse neoplasia and immunity: effects of radiation, hyperthermia, 2-deoxy-d-glucose, and corynebacterium parvum.	radiation (xrt), hyperthermia, 2-deoxy-d-glucose (2dg), and corynebacterium parvum were given in various combinations to balb/c mice injected with herpes virus type 2-transformed (h238) cells. addition of heat significantly increased the antitumor effects of xrt, and the combination of xrt + 2dg + heat resulted in the highest incidence of complete tumor regression. enhanced activity of phytohemagglutinin-responsive t lymphocytes and natural killer cells capable of killing yac-1 tumor cells was n ...	1985	4069554
the effect of hemopoietic microenvironment on splenic suppressor macrophages in congenitally anemic mice of genotype sl/sld.	mechanisms underlying mononuclear phagocyte specialization are being probed by studying suppressor macrophages (m phi) as a reference population in mouse models with impaired blood monocyte formation. splenic suppressor m phi, defined by pge-mediated inhibition of con a-induced t lymphocyte proliferation are induced by the i.p. administration of corynebacterium parvum (cp). mice severely depleted of bone marrow and blood monocytes by treatment with 89sr fail to show this suppressor m phi respons ...	1985	4067308
an immunological follow-up of chronic adnexitis.		1985	4061184
[studies on the hepatocellular injury in an experimentally induced acute hepatic failure. ii. changes in spleen cell and peritoneal macrophage functions].		1985	4057657
the serologic response of patients with stage ii melanoma to allogeneic melanoma cell vaccines.	seventeen patients with stage ii malignant melanoma were treated with vaccines prepared from three allogeneic melanoma cell lines in an attempt to induce a humoral immune response against melanoma cell surface antigens. the patients were free of detectable melanoma at the time of vaccination. vaccines were prepared from three melanoma cell lines that expressed highly restricted melanocyte differentiation antigens. one of these cell lines also expressed an antigen found only on this particular li ...	1985	4052966
[treatment of neoplastic pleural effusion by intrapleural administration of corynebacterium parvum vaccine].		1985	4047949
[alveolar lymphocyte proliferation in sarcoidosis patients induced by propionibacterium acnes].		1985	4046241
disappearance and reappearance of resident macrophages: importance in c. parvum-induced tumoricidal activity.	we have investigated the role of resident macrophages in the early tumoricidal response to c. parvum. the bacteria were labeled with fitc and resident cells were labeled in situ with blue fluorescent covaspheres to enable subsequent monitoring of cellular changes by flow cytometry. macrophages disappeared within 5 hr of administration of bacteria. at 24 hr, fibrinous adhesions containing double labeled macrophages were observed at numerous sites on the peritoneum. macrophages associated with lar ...	1985	4038473
further experience of corynebacterium parvum in malignant pleural effusion.	the outcome of drug induced pleurodesis has been evaluated in a non-randomised retrospective study of 67 patients with recurrent malignant pleural effusions treated during 1976-83. fourteen died within 30 days of treatment. of the remaining 53 patients, 26 studied during 1976-80 were treated with intrapleural mustine hydrochloride, while 27 studied during 1978-83 were treated with intrapleural corynebacterium parvum. there was no significant difference between the groups in age, sex, or tumour t ...	1985	4035618
[proliferative response of murine lymphocytes caused by the activity of amphiphilic molecules from propionibacterium acnes].	splenic lymphocytes from mice treated with propionibacterium acnes cells as well as with their cell walls were found to be variably active on the lymphoproliferative responsiveness. furthermore, the effect of these bacterial agents on the ex vivo con a response of the lymphocytes showed a certain stimulation that was higher with oral treatments. in the same conditions the influence of these agents on the lps lymphocytes stimulation was almost without any statistical significance. in vitro blasto ...	1985	4035056
experimental photoallergy to systemic drugs.	we have induced photoallergy in mice to systemically administered drugs, specifically sulfanilamide and chlorpromazine. mice were photosensitized to systemic sulfanilamide or chlorpromazine by i.p. administration of drug followed by uvb and uva irradiation of shaved flank skin, on two consecutive days. control mice received i.p. drug with no irradiation. in some experiments cyclophosphamide pretreatment, or intradermal corynebacterium parvum (propionibacterium acnes), was administered as an immu ...	1985	4031536
structure of acidic polysaccharide from cell wall of propionibacterium acnes strain c7.	the structure of polysaccharide prepared by lysozyme digestion from the cell wall of propionibacterium acnes strain c7 was examined. the polysaccharide fraction was composed of glucose, galactose, mannose, galactosamine, and diaminomannuronic acid in a molar ratio of 1:1:0.3:1:2. by smith degradation of the polysaccharide, diaminouronic acid-containing fractions were obtained, and the configuration of diaminouronic acid was identified as 2,3-diacetamido-2,3-dideoxymannuronic acid [man(nac)2a] by ...	1985	4030744
repression of lymphatic metastasis by a second implant of the same tumor.	previous work in the rat d-12 fibrosarcoma model has shown that the incidence of macroscopic metastasis, located primarily in regional lymph nodes, is markedly increased after surgical removal of a primary subcutaneous tumor implant, in all probability by facilitating the outgrowth of already established micrometastases. the present work shows that a second implant of live d-12 tumor cells into a remote site effectively represses the outgrowth of macroscopic metastases. for the manifestation of ...	1985	4030246
purification and partial amino acid sequence of rabbit tumor necrosis factor.	good production of tumor necrosis factor (tnf) in the rabbit was obtained using propionibacterium acnes iid 912 as a priming agent and subsequent administration of lipopolysaccharide. the physicochemical characteristics of rabbit tnf were very similar to those of murine tnf. the molecular weight of rabbit tnf was 39,000 as estimated by gel filtration, and 18,000 by sds-page. the isoelectric point was determined as ph 4.0 by isoelectric focusing. rabbit tnf was stable within the ph range of 5.5 t ...	1985	4030139
rejection of murine ovarian cancer following treatment with regional immunotherapy: correlations with a neutrophil-mediated activation of cytostatic macrophages.	rejection of the murine ovarian teratocarcinoma (mot) in c3heb/fej mice, following intraperitoneal (ip) treatment with corynebacterium parvum (c. parvum), is abrogated by injections of silica. we, therefore, investigated whether c. parvum-elicited macrophages affect mot targets in vitro. tumor-cytostatic, but not cytolytic, macrophages were detected in normal and tumor-challenged mice treated with c. parvum. the dose responsiveness and kinetics of macrophage activation strongly correlated with t ...	1985	4028167
synergistic effects of combination sequential immunotherapies in a murine ovarian cancer model.	the antitumor effects of corynebacterium parvum in a murine ovarian teratocarcinoma model depend upon a sequential activation of neutrophils and macrophages within the peritoneal cavity. we studied the sequential administration of biological response modifiers that independently activate each phase of the response. tumor-challenged mice treated by i.p. injection of a pyridine-extracted fraction of cell-free propionibacterium acnes (pa-pe, 1400 micrograms) demonstrated prolonged survival in less ...	1985	4028011
[studies on hepatocellular injury in experimentally induced acute hepatic failure--i. possible involvement of the activated adherent cells].		1985	4021165
ganglioside alterations in stimulated murine macrophages.	a two-dimensional thin-layer chromatographic technique has been used to separate and display gangliosides from murine peritoneal macrophages in different functional states. resident macrophages have a relatively simple ganglioside pattern with about 15 resorcinol-positive spots. gangliosides from resident cells contained mostly (90%) n-glycolylneuraminic acid. thioglycolate-elicited and corynebacterium parvum-activated macrophages have much more complex patterns with about 40 resorcinol-positive ...	1985	4016115
can technetium-labelled millimicrospheres be used to measure kupffer-cell function? an experimental study.	it has been suggested that sodium pertechnetate 99mtc millimicrospheres can be used to measure kupffer-cell function. we studied animals and humans to show whether the clearance and catabolism of 99mtc-labelled millimicrospheres can be used as a measure of kupffer-cell function. comparison with albumin 125i-microaggregates clearance of human serum albumin failed to demonstrate that they can be used for this purpose. we suggest that their blood clearance is mainly an expression of liver blood flo ...	1985	4006979
role of lipid a of endotoxin in the production of tumour necrosis factor.	bacterial lipopolysaccharide (lps) induces the release of tumour necrosis factor (tnf) into serum of mice previously infected with listeria monocytogenes or immunized with formalin-killed corynebacterium parvum. this release is greatly reduced by neutralisation of lipid a of lps with the antibiotic polymyxin b sulfate. the effect is dose-dependent. base-hydrolysed lps, which is devoid of lipid a, cannot induce tnf release. crude lipid a still retains its ability to induce tnf release but is sign ...	1985	4000132
the quantity and function of pulmonary alveolar macrophages after splenectomy and corynebacterium parvum.	we have previously shown that corynebacterium parvum (c. parvum), a nonspecific immunomodulator, partially protects splenectomized and nonsplenectomized mice when challenged with aerosolized pneumococci. we report here the effects of both splenectomy and c. parvum on the phagocytic function of the lavageable pulmonary alveolar macrophage (pam). groups of young adult male sprague dawley rats underwent splenectomy or sham operation 3 weeks before injection of c. parvum 1.5 mg ip (or saline) per an ...	1985	3999160
production of tumour necrosis factor in listeria monocytogenes-infected animals.	both mice and rabbits injected intravenously with viable listeria monocytogenes and challenged with bacterial lipopolysaccharide release tumour necrosis factor (tnf) into the blood. optimal conditions for production of murine tnf using listeria were established. the cell-kill efficacy of listeria-tnf and of corynebacterium parvum-tnf are comparable. also, the two sera have similar spectra of activity; a wide variety of murine and human tumour cell lines are vulnerable while others are not affect ...	1985	3997317
corynebacterium parvum augments antibody production in splenectomized mice and mice with sham operations.	the antibody response to a variety of antigens, including pneumococcal polysaccharides, is diminished in splenectomized (splx) mice. we investigated the capacity for the biological response modifier corynebacterium parvum to augment antibody production in splx and sham-splx mice inoculated with pneumococcal polysaccharides and tetanus toxoid. as expected, antibody response to tetanus toxoid was similar in both splx mice and sham-splx mice. c. parvum augmented anti-tetanus toxoid antibody in both ...	1985	3997248
photodestruction of propionibacterium acnes porphyrins.	the fluorescence spectra of colonies of propionibacterium acnes were studied under various experimental conditions. the spectra contained peaks at 580 nm and 620 nm. these bands were due to two different components; the 580 nm component was likely to be a metalloporphyrin, and there are indications that the 620 nm component could be a coproporphyrin. the 580 nm fluorescence was destroyed by the combined action of light and oxygen (no destruction under strict anaerobic conditions). a dark period ...	1985	3993179
prevention of tumor metastasis after surgical removal of primary tumor by using in vitro activated macrophages.	in vitro activation of peritoneal macrophages by propionibacterium acnes and its immunotherapeutic potential for inhibiting metastasis was investigated. c3h/hen mouse adherent peritoneal exudate cells as a source of macrophages were treated in vitro with p. acnes. these p. acnes-activated macrophages were tested for tumoricidal activity in vitro and antimetastatic activity in vivo. in vitro cytotoxicity tests revealed that they had potent cytotoxicity. surgical resection of x5563 tumors in synge ...	1985	3981817
treatment of malignant pleural effusions with intrapleural corynebacterium parvum or tetracycline.	thirty two patients with malignant pleural effusion were randomly allocated to treatment with intrapleural corynebacterium parvum or tetracycline hydrochloride in an attempt to prevent symptomatic recurrence of pleural fluid. success in preventing recurrence of fluid at one month, using up to 2 doses of each drug, was 14 of 16 cases for corynebacterium parvum, 5 of 9 for tetracycline given via an intercostal needle, and 6 of 7 for tetracycline given through an intercostal tube. these difference ...	1985	3979476
enhanced thermal response of a rat sarcoma by corynebacterium parvum.	corynebacterium parvum was investigated in the response of rat mc7 sarcoma to local waterbath hyperthermia. heat treatment of 1-1.5 cm3 foot tumors at 43 degrees c for 2 h resulted in complete regression of 71% of the tumors. the mc7 cure was reduced to 31% when the tumors were heated at 43 degrees c for 1.5 h. c. parvum (700 micrograms, i.v.) when given 1-3 days before tumor heating at 43 degrees c for 1.5 h increased the host phagocytic activity, and the tumor regression from 31% to 65% (p les ...	1985	3978610
modulation of hepatocyte protein synthesis during co-cultivation with macrophage-rich peritoneal cells in vitro.	the etiology of hepatic failure associated with the multiple-system organ failure syndrome is poorly understood. because of indirect evidence suggesting that macrophages or kupffer's cells may play a role in this phenomenon, macrophage-rich peritoneal cells were co-cultured with isolated rat hepatocytes. following co-culture, the rate of hepatocyte protein synthesis, quantitated by counts per minute of tritiated leucine incorporated into protein, was significantly diminished. this modulation of ...	1985	3977588
imbalanced accumulation of ribosomal rna in macrophages activated in vivo or in vitro to a cytolytic stage.	previous studies have shown that peritoneal murine macrophages activated in vivo and in vitro to a tumoricidal stage have a depressed rate of rna synthesis. in attempting to clarify the differences in rna metabolism between noncytotoxic and tumoricidal macrophages, we have studied the relative accumulation of various species of rna in macrophages activated in vivo and in vitro with the use of agarose gel electrophoresis. macrophages activated in vitro to a cytotoxic stage with supernatants conta ...	1985	3965571
determination of protein in polysaccharide-antibody complexes.	we describe a simple and sensitive method for determining antibody protein complexed with polysaccharide using binding of amido-black to antigen-antibody complexes and bovine serum albumin as protein standard. the method, which is a modification of the method used for the determination of total nitrogen or the protein concentration in milk, has shown a consistent quantitative relationship with the lowry procedure and has been developed for its particular application to serological precipitates.	1986	3963752
adjuvant and antitumour activities of synthetic lipid a analogues.	the biological activities of synthetic glycolipids, which were chemically synthesized and based on the structure of lipid a of the lipopolysaccharide (lps) from escherichia coli, were examined with special reference to their adjuvant activity on the induction of delayed-type hypersensitivity, activity on the induction of tumour necrotic factor (tnf) and tumour regressive activity on line 10 hepatoma in strain 2 guinea pigs. among them, a compound structurally corresponding to free e. coli lipid ...	1986	3962449
suppressive effects of 3-methylcholanthrene on the in vitro antitumor activity of naturally cytotoxic cells.	transient suppression of splenic natural killer (nk), natural cytotoxic (nc), and peritoneal macrophage cytotoxicity was observed following a single injection of 3-methylcholanthrene (3-mc) into c3h/hen mice. natural killer cell activity was depressed by 30-60% 4-6 d after injection of 1.0 mg 3-mc. levels of nk reactivity returned to normal 8 d post 3-mc injection, and no suppression of natural killing was seen when tested 6 wk after 3-mc treatment. 3-mc did not affect propionibacterium acnes au ...	1986	3959116
origin and differentiation of natural killer cells. ii. functional and morphologic studies of purified nk-1.1+ cells.	cells bearing the nk-specific marker nk-1.1 were purified from mouse spleens by utilizing a monoclonal anti-nk-1.1 antibody and cell sorting. in normal adult mice, all of the splenic nk activity against yac-1 cells was found in the nk-1.1+ fraction, whereas nk-1.1- cells were depleted of nk activity. the nk activity of sorted nk-1.1+ cells was enriched 15- to 30-fold over unfractionated spleen cells. light and electron microscopic studies of purified nk-1.1+ cells showed a homogeneous population ...	1986	3958492
bacterial lipases and chronic blepharitis.	eyelids and conjunctivae of 36 normal individuals and 60 patients from six clinical groups of chronic blepharitis were cultured for aerobic and anaerobic bacteria. the most common species isolated were coagulase-negative staphylococci (c-ns) and propionibacterium acnes. all strains of these species, and all staphylococcus aureus strains isolated were tested for the ability to break down triglycerides, cholesterol esters, and fatty waxes. each strain was incubated independently with appropriate s ...	1986	3957566
an action spectrum for blue and near ultraviolet inactivation of propionibacterium acnes; with emphasis on a possible porphyrin photosensitization.		1986	3952162
the microbial flora of the continent cecal urinary reservoir, its stoma and the peristomal skin.	the bacteria occurring in reservoir urine, on the cutaneous stoma and on the abdominal skin were studied in 9 patients who had undergone urinary diversion via a continent cecal reservoir. aerobic and/or facultatively anaerobic bacteria were isolated persistently from reservoir urine in 3 patients but only occasionally in the remainder. these organisms were isolated in pure culture. anaerobic bacteria also were found, although infrequently and only in conjunction with facultative anaerobes. most ...	1986	3944854
ability of oral bacteria to degrade fibronectin.	the fibronectin-degrading ability of 116, mainly oral, strains was assayed by using plasma-derived fibronectin adsorbed to a polystyrene surface. ability to degrade fibronectin was revealed in strains of bacteroides gingivalis, bacteroides intermedius, bacteroides loeschii, staphylococcus aureus, staphylococcus epidermidis, peptococcus prevotii, clostridium sporogenes, and propionibacterium acnes. the fibronectinolytic activity of subgingival bacteriological samples was found to be related to th ...	1986	3943910
arthropathic properties of cell wall polymers from normal flora bacteria.	peptidoglycan-polysaccharide (pg-ps) fragments were purified from cell walls of group d streptococci (streptococcus faecium, strains atcc 9790 and f-24) with a protocol which minimizes autolytic activity and tested for ability to induce arthritis in rats. pg-ps fragments from cell walls of other normal flora bacteria (peptostreptococcus productus, and propionibacterium acnes), group a streptococci, and pseudomurein-ps fragments from cell walls of methanobacterium formicicum, were similarly purif ...	1986	3940996
evaluation of the sterility and stability of insulin from multidose vials used for prolonged periods.	diabetic patients frequently use their insulin vials for prolonged periods, even though antibacterial preservatives used in multidose insulin vials are not required to be effective beyond 28 days. for this reason, we evaluated the antibacterial activity present in multidose insulin vials for up to 50 days. multidose lente insulin vials were inoculated with s. aureus and p. aeruginosa. vials incubated at room temperature (21 degrees c) were sterile by 48 hours, whereas when they were incubated at ...	1985	3935593
[experimental studies on the amplification of anti-tumor effects using bacterial dna-treated cancer cells, immunoactivators and interferon].		1985	3934297
the effect of combination treatment with alpha-difluoromethylornithine and corynebacterium parvum on b16 melanoma growth and tumoricidal effector cell generation in vivo.	the objective of the present investigation was to establish whether a known lymphoreticular-stimulating agent corynebacterium parvum would augment the established antitumor activity of alpha-difluoromethylornithine in vivo. furthermore, since c. parvum is known to boost cell mediated cytotoxicity, the effect of dfmo (dl-alpha-difluoromethylornithine x hcl x h2o) treatment was evaluated on macrophage and natural killer (nk) cell tumoricidal activity. dfmo administered alone, 1% or 2% in drinking ...	1985	3933819
cytotoxic factor production by kupffer cells elicited with lactobacillus casei and corynebacterium parvum.	the ability of kupffer cells, spleen macrophages, pulmonary macrophages, and peritoneal macrophages (pm) to produce cytotoxic factor (ctf) was investigated in vitro. the production of ctf by kupffer cells elicited with corynebacterium parvum (cp) or lactobacillus casei yit9018 (lc9018) was higher than that of spleen, pulmonary macrophages, or pm. in addition, oxygen radical (or) production by kupffer cells or pm was measured. the production of or by kupffer cells or pm was significantly augmente ...	1985	3930066
decreased production of interferon alpha and interferon gamma in leucocyte cultures of schizophrenic patients.	in a first approach to measure the activity of the interferon system in schizophrenic patients, leucocyte cultures of schizophrenic patients and normal control individuals were set up using a whole blood assay. in this system both lymphoproliferation and the induction of interferon was tested. the lymphoproliferation (lp) test was performed with one bacterial recall antigen (ppd) and four different mitogens (phytohemagglutinin (pha), concanavalin a (con a), pokeweed mitogen (pwm) and a novel mit ...	1985	3929565
[effect of c. parvum-activated macrophages on tumor cells: a microcinematographic study].		1985	3928111
drug influences on rat hepatic macrophage enzyme production and release in vitro.	drug influences on hepatic macrophage enzyme release have been investigated using a rat model of macrophage recruitment and activation. n-acetyl-glucosaminidase (nag), a lysosomal enzyme, and plasminogen activator (pa), a cytosolic enzyme, have been measured in both cell lysates and supernatants after 24 h in culture. 6-mercaptopurine (6-mp) and azathioprine significantly decreased (p less than 0.03) the enhanced production of nag by recruited macrophages following stimulation in vitro (total na ...	1985	3926509
t cell involvement in production of tumor necrosis factor: reconstitution experiments with nude mice.	in order to investigate the role of t cells in the production of tumor necrosis factor (tnf), a reconstitution experiment was performed with nude mice (balb/c, nu/nu). the results obtained were as follows: 1) the cytotoxic activity of tumor necrosis serum (tns) from balb/c, nu/nu mice treated with propionibacterium acnes-lps was 1/22 of that from balb/c, nu/+ mice. 2) tnf activity increased 14 times in reconstituted nude mice as compared to balb/c, nu/nu mice. 3) the production of the cytotoxic ...	1985	3924713
protective effect of lactobacillus casei on pseudomonas aeruginosa infection in mice.	the protective effect of heat-killed lactobacillus casei yit9018 (lc 9018) against pseudomonas aeruginosa infection in mice was compared with that of corynebacterium parvum. survival of mice after intraperitoneal (i.p.) infection with p. aeruginosa was augmented in mice that had been pretreated i.p. with lc 9018 5 days previously. similar treatment of mice with c. parvum, however, was not effective at all. moreover, mice became more susceptible to infection with p. aeruginosa after such treatmen ...	1985	3921464
effects of dilution rate on biomass and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture.	propionibacterium acnes, p. avidum and p. granulosum were grown in continuous culture at a range of dilution rates on a semi-synthetic medium. dilution rates were chosen to allow the bacteria to grow at the same relative growth rates as compared to their respective mumax values. the steady-state levels and production rates of biomass and extracellular enzymes were determined. the lipase and hyaluronate lyase of p. granulosum and the proteolytic activity of p. acnes and p. avidum were growth link ...	1985	3900281
adjuvant therapy of cutaneous malignant melanoma: a critical review.	the emergence of revised definitions for the high-risk patient with cutaneous malignant melanoma prompts us to re-examine the current status of adjuvant therapy in this disease. we wish to address the question, "once a cutaneous melanoma is surgically removed and the patient is currently free of disease but at high risk for metastases, what can be done to prevent recurrence"?	1985	3897817
quantitative measurements of humoral immune response in mice to a fanft induced bladder tumor.	using unfixed mouse bladder tumor cells (mbt) as target cells and a modified avidin-biotin-complex (abc) method made it possible to detect a humoral immune response in c3h mice with growing mbt tumors. the rise of the serum levels is significant (p less than 0.005) when compared to control animals and correlates with the tumor size. mice with recurrences after surgical removal of the primary tumor had significantly (p less than 0.05) higher serum values than animals without recurrence. purulent ...	1985	3895707
production of tumor necrosis factor in germfree mice.		1985	3895238
analysis of protective mechanisms against infection by serratia marcescens.	the present paper is concerned with an experimental study of effects of some agents on parameters pertinent to host resistance to infection of serratia marcescens (s. marcescens) which was isolated from a patient. the results obtained are the following: in the control mice injected intravenously with s. marcescens, most of the bacteria were trapped in the liver, spleen and lung, the so-called reticuloendothelial system (res), and the number of bacteria decreased gradually with time. in the kidne ...	1985	3894671