Publications

[the topographic anatomical basis for ventriculosinusal shunting in hydrocephalus in nursing and young infants].	the peculiarities in the structure and topographic anatomical relations of the superior longitudinal, lateral, and sigmoid sinuses were studied on block preparations of the posterior cranial fossa of 14 children under 3 years of age who died from somatic diseases. it was shown that intrasinus inclusions preventing catheterization of the sinus (bands and septa) were absent at the junction of the first angle of the sigmoid sinus with its descending part. the authors recommend this area for shuntin ...	2007	2168650
somatostatin receptor incidence and distribution in breast cancer using receptor autoradiography: relationship to egf receptors.	somatostatin receptors (ss-r) were measured with in vitro receptor autoradiography using the ss analog 125i-[tyr3]-sms 201-995 as radioligand in 342 breast-tumor samples. in a group of 158 "small" tumor samples (mean section surface: 14 mm2 +/- 0.4; mean +/- sem), 34 tumors (21%) were ss-r positive. in a group of 72 "large" tumor samples (mean size: 180 mm2 +/- 8; mean +/- sem), 33 tumors (46%) were ss-r positive. in this second group, more than half of the tumors had a non-homogeneous distribut ...	2007	2168344
the antiphospholipid antibody dilemma.		2007	2168305
role of oxygen free radical formation in the mechanism of menogaril resistance in multidrug resistant tumor cells.	the mechanisms of action and resistance to menogaril, a clinically active anthracycline antitumor drug, were evaluated in sensitive and doxorubicin-selected multidrug resistant human breast tumor (mcf-7) cell lines. while mcf-7/adrr cells were highly resistant (250-500-fold) to doxorubicin, they displayed only marginal resistance (10-fold) to menogaril. in contrast to doxorubicin, the mechanism of resistance to menogaril in these cells does not involve differential inhibition of dna synthesis as ...	1990	2168296
[methods of determining clinically sufficient decurarization and its evaluation].	mechanomyoscopy as an objective method for determining the degree of decurarisation is particularly useful in the case of uncooperative patients and those who are incapable of adequate neck flexion mostly for spinal column diseases. the authors use for that purpose a czechoslovak-made neuromuscular stimulator (lsn 110), with constant 50 hz frequency of stimulation, 0.3 ms impulse duration, max. 50 ma and, depending on skin impedance, 5-140 v. the stimulator switch is manually controlled. the abs ...	2007	2168290
characterization of two low em forms of cytochrome a3 and their carbon monoxide complexes in mammalian cytochrome c oxidase.	evidence is presented for the existence of two forms of low-potential cytochrome a3. one appears to be similar to the low-spin form reported by nicholls, p., and v. hildebrandt (1978 biochem. j. 173:65-72) and wrigglesworth, j. m., j. elsden, a. chapman, n. van der water, and m. f. grahn (1988. biochim. biophys. acta. 936:452-464). it has a reduced soret peak near 428 nm and a prominent alpha peak near 602 nm. this form is seen when the enzyme is either supplemented with lipoprotein or incorpora ...	1990	2168220
local control of operable breast cancer after radiotherapy alone.	221 patients with operable breast carcinoma stage tis, t1, t2, t3, n0n1 were treated with radiotherapy alone without tumorectomy. the mean follow-up time was 15.5 years (range 5-22). the annual risk for local recurrence was 3% during the first 5 years and 1% during the following 10 years, resulting in an actuarial local control rate of 75.4% after 15 years. the risk for local recurrence was assessed in multivariate analysis and was significantly related to the size of the tumour measured on mamm ...	2007	2168190
kinetics of the reaction of prostaglandin h synthase compound ii with ascorbic acid.	the reduction of prostaglandin h synthase compound ii by ascorbic acid in the presence of diethyldithiocarbamate was studied in 0.1 m phosphate buffer (ph 8.0) at 4.0 +/- 0.5 degrees c, by rapid scan spectrometry and transient state kinetics. a saturation effect and nonzero intercept were observed in the plot of pseudo-first-order rate constant versus ascorbic acid concentration. the saturation behavior suggests formation of a complex between prostaglandin h synthase compound ii and ascorbic aci ...	1990	2168160
[the diagnostic value of mr tomography following gadolinium-dtpa compared to computed tomography in bladder tumors].	in a prospective study, 58 patients with carcinomas of the bladder were examined by ct and mri; in 48, gadolinium-dtpa was administered intravenously. mri provided exact staging in 89%, compared with 80% with ct. there was 13% over-staging with ct and 11% with mri. mri, unlike ct did not result in any under-staging. in 36 patients a quotient could be calculated from the signal intensity of the tumour and surrounding soft tissues both before and after the intravenous contrast medium and the incre ...	2007	2168077
phenotypic evaluation of acapsular transposon mutants of vibrio vulnificus.	translucent, avirulent spontaneous phase variants of vibrio vulnificus mo6-24 reverted back to the original opaque, encapsulated phenotype under both in vivo and in vitro conditions. two translucent, acapsular mutants, which did not show phase variation, were constructed by using the transposon tn5 is50l::phoa (tnphoa). loss of capsule was accompanied by decreases in virulence, hydrophilicity, and serum resistance. the ability to utilize transferrin-bound iron for growth was lost in only one of ...	1990	2160432
[avoid errors. preparation of abutments for removable denture cast framework].		2007	2151674
permeability-enhancing action of vibrio vulnificus protease and its control system.		1990	2101153
[derivative spectroscopy and its use in sanitary hygiene control].	an analytical method is developed for defining the residual quantities of rodenticide "brodifacoum" (talon) used in the control of harmful field rodents and especially for species microtus. the method is based on extracting the pesticide with chloroform and making use of spectrophotometry in the ultraviolet field in intervals 340-240 nm. the second derivative of the absorption is utilized as well as the band with maximum 288 nm and minimum 228 nm. the peak height in this interval is in proportio ...	2007	2099444
[the significance of the determination of catecholamines and their metabolites in neuroblastomas].	a method for the determination of catecholamines and their metabolites in the urine was established. the specimens were previously cleaned by ion exchangers and the components were separated by a 'reversed phase' ionic pair chromatography, determined by an electrochemical 'wall-jet'-detector. this method was applied in order to find a diagnostic marker in case of neuroblastoma diseases. in 85 per cent of the patients (n = 13) we stated an increased ejection of dopamine.	2006	2095056
[experiences in incidence monitoring and control of the pharaoh ant in a health resort].	today monomorium pharaonis still represents a threat of the hygiene regime in the objects of public health and welfare, particularly for the asepsis and the "black-white-separation". the experiences collected throughout a successful rub out by the preparate "lafarex n 87" in a health-resort are presented. the necessity of cooperation of all concerned persons (owners, pest control enterprises and public hygiene service) are emphasized.	2005	2095048
enhancement of virulence of two environmental strains of vibrio vulnificus after passage through mice.	the virulence of two environmental strains of vibrio vulnificus to iron-loaded adult mice was enhanced by passage through mice. estimates of 50% lethal dose values (ld50) determined by end point titration were reduced 100- and 1000-fold for the two strains. passage through mice also selected for the opaque colony type phase variation of v. vulnificus, reported by others to be more virulent to mice than a translucent colony type.	1990	2076589
[a juvenile form of osteochondrosis].		2007	2074966
scalp cooling by cold air for the prevention of chemotherapy-induced alopecia.	a new system is described for cooling the scalp with cold air in order to prevent chemotherapy-induced alopecia. compressed air was cooled by means of a vortex tube built into a hair-drier cap. this system reduced the blood flow in the scalp to 35%, the surface temperature to 14.2 degrees c and the intradermal temperature at hair follicle level to 29.2 degrees c. the low temperature could be kept constant for at least one hour of cooling. by means of comparison, with cryogel packs the lowest epi ...	2007	2074916
oysters, iron overload and vibrio vulnificus septicaemia.	a case of vibrio vulnificus septicaemia complicated by cutaneous leg ulceration is described. a 74 year old man with haemochromatosis and sideroblastic anaemia developed an acute febrile illness with cutaneous manifestations 24 hours after ingesting raw oysters. the presence of blistering should be considered an important clue to the diagnosis of vibrio vulnificus septicaemia, and this can facilitate prompt effective antimicrobial therapy. clinicians should be aware of this infection because of ...	1990	2073206
electrophoretic analysis of lipopolysaccharide isolated from opaque and translucent colony variants of vibrio vulnificus using various extraction methods.	lipopolysaccharides (lps) from an opaque and a translucent colony variant of vibrio vulnificus were isolated by several methods and the electrophoretic profiles were analysed. the phenol-water extraction method provided a better yield compared to the phenol-chloroform-petroleum ether method. in addition, two rapid micro-assays were used to isolate lps for electrophoretic analysis. the electrophoretic pattern was the same for all lps extracts and was similar in both variants. no high molecular we ...	1991	2062249
vibrio vulnificus septicemia in korea: clinical and epidemiologic findings in seventy patients.	we studied the clinical characteristics and the epidemiology of primary septicemia associated with vibrio vulnificus in 70 patients. all patients came from the western and southern coastal areas of korea. most cases (96%) occurred during the summer months, in men (96%), and in persons 40 or more years of age (90%). the illness of 46 patients (66%) began with septicemia, often within 2 days of the consumption of raw seafood. forty-seven patients (67%) had preexisting hepatic disease, and 49 (70%) ...	1991	2061435
enzyme immunoassay for identification of vibrio vulnificus in seawater, sediment, and oysters.	historically, methods used to identify vibrio vulnificus in environmental samples have been inadequate because isolation and identification procedures are time-consuming and fail to separate v. vulnificus from other bacterial species. we describe an enzyme immunoassay (eia) and culture techniques which identified v. vulnificus in seawater, sediment, and oysters. the eia used monoclonal antibody frbt37 to a species-specific epitope of v. vulnificus. no cross-reactions were observed among 72 non-v ...	1991	2059045
the economics of spaying and neutering: market forces and owners' values affecting pet population control.		1991	2045338
no time for an aids backlash.		2007	2045284
zambia: focus on humanitarian care of aids patients.		2007	2045228
glucagon and clonidine testing in the diagnosis of pheochromocytoma.	we assessed the sensitivity and specificity of glucagon stimulation and clonidine suppression tests in the diagnosis of pheochromocytoma in 113 hypertensive patients, 39 with and 74 without the tumor. in the glucagon stimulation test, blood was sampled 2 minutes after intravenous injection of 0.28 mumol (1 mg) glucagon, and in the clonidine suppression test, blood was sampled 3 hours after administration of oral clonidine, 1.30 mumol (0.3 mg)/70 kg body wt. baseline levels of catechols in antecu ...	2007	2045133
coronary reserve in patients with aortic valve disease before and after successful aortic valve replacement.	in patients with aortic valve disease and normal coronary angiograms coronary reserve was determined by the coronary sinus thermodilution technique. three groups of patients were studied: 37 preoperative patients; 18 different patients 12-52 months after aortic valve replacement and seven control subjects with no cardiac disease. coronary flow ratio (dipyridamole/rest) was diminished in preoperative compared with postoperative patients (1.66 +/- 0.44 vs 2.22 +/- 0.85; p less than 0.05) as well a ...	2007	2044545
ovarian cancer.		2007	2042058
polymerase chain reaction identification of vibrio vulnificus in artificially contaminated oysters.	dnas extracted from vibrio vulnificus seeded into oyster homogenates were evaluated as templates for the polymerase chain reaction. several extraction procedures were examined, and it was determined that dna recovered from cells lysed by guanidine isothiocyanate, extracted with chloroform, and precipitated with ethanol was most suitable for use as a polymerase chain reaction template. the region targeted was a 519-bp portion of the cytotoxin-hemolysin gene of v. vulnificus. this region was ampli ...	1991	2039231
ozone depuration of vibrio vulnificus from the southern quahog clam, mercenaria campechiensis.	southern quahog clams, mercenaria campechiensis, were dosed with vibrio vulnificus and placed in a pilot-scale depuration system using ozonated recirculated artificial seawater. twenty-four hours of treatment with ozone-treated recirculating artificial seawater reduced the numbers of v. vulnificus in the shellfish meats by an average of 2 log units when compared to natural die-off in control clams. the oxidant levels (up to 3 mg/liter) did not adversely affect shellfish pumping during the depura ...	1991	2022868
purification and characterization of a secreted protease from the pathogenic marine bacterium vibrio anguillarum.	vibrio anguillarum is a pathogenic marine bacterium which causes the disease vibriosis in salmonid fish, which is characterized by a fatal hemorrhagic septicemia accompanied by massive tissue destruction. in this paper, the purification of the major caseinolytic extracellular protease from v. anguillarum is presented. the purification steps include ammonium sulfate precipitation, deae-sepharose chromatography, sephacryl s-200 chromatography, and deae high-pressure liquid chromatography. the puri ...	1991	2012804
pulmonary infiltrates associated with vibrio vulnificus septicemia.	in the case described, fatal vibrio vulnificus primary septicemia was complicated by development of diffuse pulmonary infiltrates. clinical features of this recently discovered infectious disease are discussed. various aspects of diagnoses of pulmonary infiltrates in patients with v vulnificus septicemia are also presented. vibriosis should be suspected in patients with chronic, underlying, predisposing diseases, recent ingestion of raw seafood, and characteristic skin lesions.	1991	1997461
a case of vibrio vulnificus septicaemia acquired in victoria.	the clinical features and laboratory findings of a case of vibrio vulnificus septicaemia are reported. the illness occurred in a previously well 68-year-old man who was accidentally spiked in the buttock by the dorsal spine of a flathead caught in tamboon inlet, near mallacoota, victoria. the clinical picture of an acute septicaemic illness with shock, associated with metastatic cellulitic lesions on the lower limbs progressing to bulla formation, skin necrosis, necrotising fasciitis and myositi ...	1991	1988798
pioneer neurons and target selection in cerebral cortical development.		2005	1983445
pioneer neurons and target selection in cerebral cortical development.		2005	1983445
structure-activity relationship of yohimbine and its related analogs in blocking alpha-1 and alpha-2 adrenoceptors: a comparative study of cardiovascular activities.	we investigated the selectivities and structure requirements for alpha-1 and alpha-2 adrenoceptor blocking activities of yohimbine (yo) and its 12 related analogs, such as beta-yohimbine (beta-yo), dihydrocorynantheine (dhc) and (-)indoloquinolizidine ((-)iq). the affinity of yo analogs to alpha-adrenoceptor was assessed by measuring their blockade of pressor responses to epinephrine in pithed rats. among yo structure groups, the potency order was yo greater than dhc = beta-yo greater than geiss ...	1990	1976443
dietary habits, sexual maturation, and plasma hormones in pubertal girls: a longitudinal study.	the relationships between dietary components and physical or hormonal sexual maturation in 63 pubertal girls were examined. the effects of vegetable protein and dietary fiber on breast development (b = -2.0, p less than 0.05; b = -2.6, p less than 0.05, respectively) became more pronounced in a multivariate analysis, after elimination of the linear effects of body height and energy intake. from the multivariate analysis with combinations of vegetable protein, polysaccharides, and fiber in the eq ...	2007	1951150
lead use in california industry: its prevalence and health implications.	an estimated 230,000 workers were reported to work in lead-using activities as a result of a 1986 statistical survey of employers in california. however, 68% of these workers worked in activities of relatively low hazard. this included 114,000 workers engaged in electronic soldering. over 1800 workers were reported to work in battery manufacture, a relatively high-hazard activity, but with consistent monitoring and protection. in contrast, over 4300 workers were involved in radiator repair activ ...	2007	1951050
mammography quality assurance.		2007	1950889
doping control of anabolic steroids.		2006	1940836
growth of vibrio vulnificus in serum from alcoholics: association with high transferrin iron saturation.		1991	1940460
drug use during breast-feeding.	the physicochemical and pharmacokinetic factors involved in transfer of drugs into breast milk are reviewed. passage of drugs into milk can best be viewed as a two-compartment system. various ratios of the drug concentration values in the two compartments and ratios of maternal-to-infant intake have been described. knowledge of the limitations of these methods is necessary to properly interpret and apply the literature on drug excretion into breast milk. factors involved in choosing a drug for a ...	1991	1934918
radiographic examination of the lumbar spine in a community hospital: an audit of current practice.	to assess general practitioners' decisions to request lumbar spine radiographs according to the guidelines of the royal college of radiologists.	2007	1932970
alcohol as a key area.		2007	1932941
effect of oil-contaminated sediment on the longhorn sculpin (myoxocephalus octodecemspinosus) following chronic exposure.		2007	1932866
imaging of the temporomandibular joint in juvenile rheumatoid arthritis.		2007	1932822
[the development of osseointegrated implants].		2007	1932767
cholestatic jaundice associated with captopril therapy.	captopril has attained widespread use as an effective agent in the treatment of heart failure and hypertension. dermatological, renal and haematological toxicity associated with its use has been widely described and is usually well recognized. there have been comparatively few reports implicating it as causing hepatic drug reactions. most descriptions have emphasized strongly cholestatic features, although a mixed hepatocellular cholestatic picture and predominant hepatocellular reactions have b ...	2007	1932674
observation and theory in psychoanalysis: the self psychology of heinz kohut.	the development of self psychology by heinz kohut illustrates the influence of observational method on theory formation in psychoanalysis. in 1959 kohut began to emphasize empathy and introspection over the traditional combination of free association and evenly suspended attention. this became an important part of a process of revision in psychoanalytic theory which culminated in self psychology. this paper demonstrates how and why that particular change in observational method influenced that p ...	2007	1924603
control of enterococcus faecalis sex pheromone cad1 elaboration: effects of culture aeration and pad1 plasmid-encoded determinants.	aeration of plasmid-free enterococcus faecalis strains resulted in an 8- to 16-fold decrease in sex pheromone cad1 activity in culture filtrates. levels of two unrelated pheromones, cpd1 and cam373, were unaffected by culture aeration. aeration also resulted in a decrease in the expression of conjugative transfer functions observed in cells containing pad1 trab mutations, verifying a link between trab function and pheromone "shutdown." tests with a series of pad1 mini-plasmids indicated that the ...	1991	1924555
purification and properties of a neurotensin-degrading endopeptidase from pig brain.	neurotensin (nt) endopeptidase (ec 3.4.24.16) has been purified about 800-fold from pig brain by four sequential chromatographic steps depending on ion-exchange and hydrophobic interactions. two types of preparation were studied: one from a triton x-100-solubilized membrane fraction, and the other from the soluble fraction containing 90% or more of the total activity in the homogenate. nt endopeptidase activity was monitored by high-precision liquid chromatography of the two peptide products, ch ...	1991	1905921
failure of oocyte retrieval during in vitro fertilization: a sporadic event rather than a syndrome.	failure to retrieve oocytes during in vitro fertilization (ivf) treatment was recently referred to as the "empty follicle syndrome." data on the possible repetitiveness of this during previous or subsequent ivf attempts is lacking, which limits the understanding of its significance to the involved patients. of 26 patients who had cycles during which no oocytes were retrieved, 10 were pregnant in the past and 20 had at least one other ivf cycle that yielded oocytes. there was no difference in the ...	2007	1899395
[vibrio vulnificus].	a patient sustained a knife wound while cleaning eels and subsequently severe wound infection developed. vibrio vulnificus was isolated from the wound and, on the basis of this, the main features of the epidemiology of the bacteria and the typical clinical pictures are reviewed.	1991	1897050
calcium regulation of the human pmn cytosolic 15-lipoxygenase.	addition of tracer (pg) amounts of [3h]arachidonic acid to the 120,000 x g cytosolic fraction of human polymorphonuclear leukocytes (pmns) produced [3h]-15-hete, the product of the 15-lipoxygenase, as the major metabolite. in the presence of nanomolar and low micromolar amounts of calcium, [3h]-15-hete formation was increased as much as 15-fold which corresponded to 17% conversion of added substrate. this enhancement of the cytosolic 15-lipoxygenase activity, which was reversible by egta, was in ...	1991	1892881
pet in generalized anxiety disorder.	positron emission tomography (pet) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (gad) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. in the passive viewing task, patients with gad were compared with 15 normal controls. a significant difference in pattern of absolute brain metabolism was found. patients showed lower absolute metabolic rates in basal ganglia and ...	2007	1888800
discordant expression of tuberous sclerosis in monozygotic twins.	a set of 20-year-old female japanese twins, most probably monozygotic, had clinical evidence of tuberous sclerosis (ts). they were discordant for symptoms. one of the twins exhibited facial red-brown papules (adenoma sebaceum), a dorsal shagreen patch, intracerebral calcifications, angiomyolipoma in the right kidney, and hypopigmented macules; the other had only a few hypopigmented macules. modification of ts gene expression by the effects of environmental (extrinsic) factors is suggested.	2007	1885853
functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-c3.	we have cloned a rat cdna encoding furin which is structurally related to yeast kex2 protease. products of 88 and 94 kda were obtained by in vitro transcription/translation of the cdna in the absence and presence of microsomes. when the cdna was transfected into cos-1 cells, furin was expressed as a major glycosylated form of 94 kda, accompanied by a minor proteolytic form of 86 kda, and found to be localized in the golgi complex. proalbumin and complement pro-c3 are intracellularly processed in ...	1991	1885622
hemochromatosis, iron and septicemia caused by vibrio vulnificus.	vibrio vulnificus is killed by normal human blood but grows rapidly in blood from patients with hemochromatosis. it also grows in normal blood if the saturation of the transferrin is increased or if hematin, which contains iron, is added. it is suggested that the increased availability of iron in the blood of patients with chronic iron overload is responsible for their enhanced susceptibility to infection with v vulnificus.	1991	1872665
[atypical and combined forms of infectious-allergic polyneuropathies].		2007	1865642
vibrio vulnificus sepsis presenting as leg pain and lower extremity rash.		1991	1863312
resuscitation of vibrio vulnificus from the viable but nonculturable state.	stationary-phase-grown cells of the estuarine bacterium vibrio vulnificus became nonculturable in nutrient-limited artificial seawater microcosms after 27 days at 5 degrees c. when the nonculturable cells were subjected to temperature upshift by being placed at room temperature, the original bacterial numbers were detectable by plate counts after 3 days, with a corresponding increase in the direct viable counts from 3% to over 80% of the total cell count. no increase in the total cell count was ...	1991	1860818
in vitro effect of phyllanthus amarus on hepatitis b virus.	to evaluate the effects of p. amarus on hepatitis b virus (hbv) antigens and hbv-dna, initial ethanolic extract and subsequent fractions of the plants were prepared. the whole plant material was dried, powdered and extracted with alcohol and subsequently fractionated in hexane, chloroform, butanol and finally in water. all the material were tested for in vitro effects on hbsag, hbeag and hbv-dna in serum samples positive for hbv antigens followed by the screening of respective antigens by elisa. ...	1991	1855821
[microbial spectrum and microbiological diagnosis of infectious endocarditis].	still streptococci play the most important role as causatives of infective endocarditis. as change in composition of patient groups has taken place gradually pathogens like staphylococcus epidermidis, enterococci, gram-negative rods and candida species become more and more important now. providing high-level accuracy if applied according to current rules blood culture is yet the basis for endocarditis caused by popular bacterial pathogens. if infection due to candida species is suspected additio ...	1991	1855807
[lipid metabolism disorders: diagnosis and treatment. 4: drug therapy and dietary recommendations. national cholesterin-initiative].		2006	1855762
[lipid metabolism disorders: diagnosis and treatment. 4: drug therapy and dietary recommendations. national cholesterin-initiative].		2006	1855762
signal transduction mechanism of interleukin 6 in cultured rat mesangial cells.	interleukin 6 (il-6) is one of the potent autocrine growth factors for mesangial cells. we investigated the signal transduction mechanism of il-6 in cultured rat mesangial cells. il-6 induced a transient increase of inositol 1,4,5-trisphosphate (ins 1,4,5-p3) followed by a transient and sustained increase of intracellular calcium concentration, suggesting that il-6 stimulates phosphoinositide turnover. il-6 also stimulated prostaglandin e2 (pge2) production. the il-6-concentration dependency in ...	1991	1855592
development of circadian sleep-wake rhythms in preterm and full-term infants.	we have compared the roles of neurologic maturity and environmental time cues in the development of the entrained circadian sleep-wake rhythm in the preterm and term human infant. the preterm infants (n = 19) spent some time after birth in a hospital nursery with no environmental time cues, whereas the term infants (n = 22) were exposed from birth to a cyclical light and dark environment with one major caregiver. the circadian sleep-wake rhythm in the preterm infants entrained after a similar ti ...	1991	1852533
response by dr. alden n. haffner upon receipt of the koch memorial medal 1990.		2007	1852404
regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action.	the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ...	2007	1852316
quantitation of hormone replacement induced withdrawal bleeds.		2007	1847822
cyclic amp-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase d activation.	agents which elevate cellular camp (prostaglandin e2, theophylline, and forskolin) or mimic camp action (dibutyryl camp) are known to inhibit human neutrophil activation (superoxide generation and secretion) by receptor-linked agonists such as formyl-methionyl-leucyl-phenylalanine (fmlp). herein, we show that these agents also markedly inhibit fmlp-stimulated diradylglycerol generation (assayed by mass methods). the magnitude of inhibition correlated with the ability of a given agent or combinat ...	1991	1847376
absence of na+,k(+)-atpase regulation of endosomal acidification in k562 erythroleukemia cells. analysis via inhibition of transferrin recycling by low temperatures.	transferrin (tf) acidification has been shown to be limited to ph 6 in murine balb/c 3t3 fibroblasts, human a549 epidermoid carcinoma cells, and chinese hamster ovary cells and is followed by alkalinization during recycling. in contrast, tf acidification in the human erythroleukemic cell line k562 proceeds to below ph 5.5, and alkalinization of internal tf during recycling is not observed. to explore the regulation of endosomal ph in k562 cells, we determined whether the existence of an early en ...	1991	1847374
growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes.	protein phosphorylation and dephosphorylation are involved in regulation of cell growth. we tested the hypothesis that the growth inhibitory effect of transforming growth factor beta 1 (tgf-beta 1) involves activation of protein phosphatases. exposure of human keratinocytes in culture to 400 pm tgf-beta 1 for 48 h led to 80% inhibition of dna synthesis as measured by nuclear labeling. incubation of cultured keratinocytes with 400 pm tgf-beta 1 rapidly activated (within 30 min) protein serine/thr ...	1991	1847373
the extracellular cytolysin of vibrio vulnificus: inactivation and relationship to virulence in mice.	the ca. 51-kda extracellular cytolysin of vibrio vulnificus has been proposed as a virulence factor. we inactivated the structural gene for cytolysin in fully virulent, clinical v. vulnificus strains by both transposon mutagenesis and marker exchange techniques. inactivation of the cytolysin did not affect virulence in our mouse models. the 50% lethal dose of cytolysin-negative strains was comparable to that of the cytolysin-positive parent strains after intraperitoneal inoculation with and with ...	1991	1846124
purified protein derivative of mycobacterium tuberculosis and excretory-secretory antigen(s) of toxocara canis expand in vitro human t cells with stable and opposite (type 1 t helper or type 2 t helper) profile of cytokine production.	a large series of t cell clones (tcc) specific for purified protein derivative (ppd) of mycobacterium tuberculosis (total 60) or toxocara canis excretory/secretory (tes) antigen (total 69) were established from the peripheral blood of two healthy individuals and analyzed for their profile of cytokine production in response to stimulation with either the specific antigen or the polyclonal activator phorbol myristate acetate plus anti-cd3 antibody. under both these experimental conditions, the gre ...	1991	1829097
aggressive chemotherapy for acute leukaemia frequently causes intestinal protein leakage.	cytostatic drugs are known to produce disturbances in intestinal absorption of carbohydrates. to further explore the gastrointestinal (gi) toxicity of cytostatic therapy, 37 patients with acute leukemia were investigated during and/or after remission induction courses by the use of the differential sugar absorption test (dsat) and the intestinal clearance of alpha-1-antitrypsin (claat). the ratio of the lactulose to the mannitol excretion in the urine was found abnormal in 44% of the tests. the ...	2006	1828960
aggressive chemotherapy for acute leukaemia frequently causes intestinal protein leakage.	cytostatic drugs are known to produce disturbances in intestinal absorption of carbohydrates. to further explore the gastrointestinal (gi) toxicity of cytostatic therapy, 37 patients with acute leukemia were investigated during and/or after remission induction courses by the use of the differential sugar absorption test (dsat) and the intestinal clearance of alpha-1-antitrypsin (claat). the ratio of the lactulose to the mannitol excretion in the urine was found abnormal in 44% of the tests. the ...	2006	1828960
complexity and sequence identification of 24 rat v beta genes.	twenty-four tcr v beta genes were cloned by anchored pcr from the lewis rat strain and identified by nucleotide and amino acid sequence comparisons to known mouse v beta genes. rat v beta genes exist in 17 single-member and 3 multimember subfamilies and exhibit 86 to 94 and 72 to 92% nucleotide and amino acid sequence similarities, respectively, to their mouse counterparts. a single rat gene, designated v beta 20, having no previously known mouse counterpart was identified; a closely related gen ...	1991	1828824
structure of the rabbit phospholamban gene, cloning of the human cdna, and assignment of the gene to human chromosome 6.	we have isolated and characterized genomic dna clones encoding rabbit phospholamban. only a single gene for phospholamban was detected in the rabbit genome. the phospholamban gene of 13.2 kilobases contains only one 10.5-kilobase intron, which separates exonic sequences located in the 5'-untranslated region. two potential transcription initiation sites were mapped to 335 and 185 nucleotides upstream from the translation initiation site in the mrna or 239 and 89 nucleotides upstream from the exon ...	1991	1828805
issues with radiation therapy article.		2006	1828682
issues with radiation therapy article.		2006	1828682
the use of potassium-titanyl-phosphate laser for laparoscopic removal of ovarian endometrioma.	from january 1989 through january 1990, 31 patients thought to have ovarian endometrioma at ultrasonography were treated by operative laparoscopy and potassium-titanyl-phosphate laser. the endometriomas ranged from 2 to 9.2 cm in diameter by preoperative transvaginal ultrasonography. the operative procedure used was a three-puncture technique with a 600 micron fiber attached to a potassium-titanyl-phosphate laser. the power setting was 10 w with a continuous pulse. in all cases endometriomas wer ...	2006	1828651
the use of potassium-titanyl-phosphate laser for laparoscopic removal of ovarian endometrioma.	from january 1989 through january 1990, 31 patients thought to have ovarian endometrioma at ultrasonography were treated by operative laparoscopy and potassium-titanyl-phosphate laser. the endometriomas ranged from 2 to 9.2 cm in diameter by preoperative transvaginal ultrasonography. the operative procedure used was a three-puncture technique with a 600 micron fiber attached to a potassium-titanyl-phosphate laser. the power setting was 10 w with a continuous pulse. in all cases endometriomas wer ...	2006	1828651
sensitivity to chromium-containing automobile parts.		2006	1828411
sensitivity to chromium-containing automobile parts.		2006	1828411
familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old.	the parents of sixty-three patients who were less than twenty-one years old and who had operatively confirmed herniation of a lumbar disc were interviewed regarding a history of sever back pain, sciatica, and herniated disc, to determine whether aggregation of herniation of a lumbar disc occurs in families of patients in this young age-group. the parents of sixty-three additional patients who had a non-spinal orthopaedic diagnosis (control group) were matched for age and sex with the study group ...	2007	1824705
acute intoxication as a cause of wild bird mortality in the netherlands from 1975-1989.		2007	1805755
surgical treatment of morbid obesity. a survey of overall outcome 1968-1989.	this survey evaluates benefits and costs from a policy of employing surgical treatment in selected cases of morbid obesity. between 1968 and 1978, we used end-to-side jejunoileal bypass. despite many satisfied patients, complications were frequent and severe. for the next decade, we employed various types of gastric surgery. we eventually assessed a gastric balloon, but without success. median duration of follow-up was 132 months in 145 patients with jejunoileostomy, 103 months in seven gastric ...	2006	1802626
surgical treatment of morbid obesity. a survey of overall outcome 1968-1989.	this survey evaluates benefits and costs from a policy of employing surgical treatment in selected cases of morbid obesity. between 1968 and 1978, we used end-to-side jejunoileal bypass. despite many satisfied patients, complications were frequent and severe. for the next decade, we employed various types of gastric surgery. we eventually assessed a gastric balloon, but without success. median duration of follow-up was 132 months in 145 patients with jejunoileostomy, 103 months in seven gastric ...	2006	1802626
a primary demyelinating disorder of young cattle.	the clinical signs and neuropathological changes are described in six limousin x calves that, at about one month after birth, showed signs of blindness, nystagmus, rotation of the eyes, opisthotonos, hyperprotraction of the forelegs and, in one case, apparent seizures. pathologically there was necrosis of the optic chiasma and focal areas of myelin sheath vacuolation or demyelination in certain areas of the brain, especially in the cerebellar peduncles. in one animal, kept alive for 7 months, th ...	1991	1800911
a general software package for the handling of medical images.	pics (portable imaging computer software), is a software system designed for handling and processing a variety of types of medical image. it has been designed to satisfy the following criteria: (a) the software should be portable between different items of hardware with minimal alteration; (b) there should be a simple operator interface to enable use by inexperienced users, while avoiding the need for experienced users to be directed through tedious menu trees; (c) the programming environment sh ...	2006	1800747
a general software package for the handling of medical images.	pics (portable imaging computer software), is a software system designed for handling and processing a variety of types of medical image. it has been designed to satisfy the following criteria: (a) the software should be portable between different items of hardware with minimal alteration; (b) there should be a simple operator interface to enable use by inexperienced users, while avoiding the need for experienced users to be directed through tedious menu trees; (c) the programming environment sh ...	2006	1800747
occult rupture of spleen.		2007	1800517
inbreeding in saguenay-lac-st-jean (quebec, canada): a study of catholic church dispensations 1842-1971.	saguenay-lac-st-jean (slsj) is a rather geographically isolated region of quebec which shows a high occurrence of hereditary disorders. it has been suggested that high inbreeding might explain this situation. we studied the inbreeding in the slsj region by 10-year periods from 1842 till 1971 using the catholic church dispensations. the values of the mean inbreeding coefficient were found to be low during the whole period, reaching a peak of 22.94 x 10(-4) during the period 1902-1911. the values ...	2007	1797631
transcatheter management of pseudoaneurysms complicating pancreatitis.	hemorrhage from rupture of an arterial pseudoaneurysm is a potentially fatal complication of pancreatitis. seventeen patients underwent transcatheter embolization of 23 arteries for the treatment of 20 arterial pseudoaneurysms secondary to pancreatitis. their records were reviewed retrospectively to evaluate the clinical benefit of transcatheter therapy. at presentation, 15 of the 17 patients had gastrointestinal, intrasplenic, retroperitoneal, intraperitoneal, or postoperative wound bleeding. t ...	2006	1797219
transcatheter management of pseudoaneurysms complicating pancreatitis.	hemorrhage from rupture of an arterial pseudoaneurysm is a potentially fatal complication of pancreatitis. seventeen patients underwent transcatheter embolization of 23 arteries for the treatment of 20 arterial pseudoaneurysms secondary to pancreatitis. their records were reviewed retrospectively to evaluate the clinical benefit of transcatheter therapy. at presentation, 15 of the 17 patients had gastrointestinal, intrasplenic, retroperitoneal, intraperitoneal, or postoperative wound bleeding. t ...	2006	1797219
unconjugated and conjugated bilirubin pigments during perinatal development. iii. studies on serum of breast-fed and formula-fed neonates.	the process of conjugation and secretion of bilirubin was studied in a group of healthy, full-term, exclusively breast-fed newborns and a control group of exclusively formula-fed infants by means of a reverse-phase high-performance liquid chromatographic analysis of bilirubins present in serum. the serum concentrations of unconjugated bilirubin, esterified bilirubin, and the proportion of diesterified bilirubin (as percent of esterified bilirubin) were not significantly different in breast- and ...	1991	1797114
unconjugated and conjugated bilirubin pigments during perinatal development. iii. studies on serum of breast-fed and formula-fed neonates.	the process of conjugation and secretion of bilirubin was studied in a group of healthy, full-term, exclusively breast-fed newborns and a control group of exclusively formula-fed infants by means of a reverse-phase high-performance liquid chromatographic analysis of bilirubins present in serum. the serum concentrations of unconjugated bilirubin, esterified bilirubin, and the proportion of diesterified bilirubin (as percent of esterified bilirubin) were not significantly different in breast- and ...	1991	1797114
a role for nmr in alcoholism?		2006	1796991
a role for nmr in alcoholism?		2006	1796991