Publications

the electrocardiogram of european shrews.	a recording method of electrocardiograms in resting animals is described. the electrocardiograms of crocidura russula, crocidura leucodon, crocidura suaveolens, neomys fodiens and sorex araneus are similar to those of other small mammals. t-wave directly follows the qrs-complex. the duration of electrocardiograms depends on heart mass and body temperature. heart rate shows no influence on the duration of electrocardiograms.	2007	2870871
the electrocardiogram of european shrews.	a recording method of electrocardiograms in resting animals is described. the electrocardiograms of crocidura russula, crocidura leucodon, crocidura suaveolens, neomys fodiens and sorex araneus are similar to those of other small mammals. t-wave directly follows the qrs-complex. the duration of electrocardiograms depends on heart mass and body temperature. heart rate shows no influence on the duration of electrocardiograms.	2007	2870871
blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis.	salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ...	1986	2870860
blood-finding strategy of a capillary-feeding sandfly, lutzomyia longipalpis.	salivary gland homogenates of adult female lutzomyia longipalpis inhibited platelet aggregation induced by adp and collagen. apyrase (atp diphosphohydrolase) activity was prominent, requiring ca2+ but not mg2+ and a ph optimum of 8.0. human as well as rabbit hosts developed a well delimited erythema, evident 2-3 min after initial probing and lasting for as long as 2 days. erythema, not accompanied by itching or swelling, developed in previously exposed hosts as well as in those not previously ex ...	1986	2870860
retention of a functional resact receptor in isolated sperm plasma membranes.	resact, a peptide obtained from eggs, causes a change in the mr, and a loss of 32p from a plasma membrane protein identified as guanylate cyclase. here, a resact analog (125i-[tyr1, ser8] resact) was synthesized and shown to bind to isolated sperm membranes. resact, but not speract, competed with the radiolabeled ligand for binding. when membranes were prepared under appropriate conditions, guanylate cyclase remained at mr 160,000; the incubation of membranes with gamma-32p-atp resulted in the f ...	2007	2870813
retention of a functional resact receptor in isolated sperm plasma membranes.	resact, a peptide obtained from eggs, causes a change in the mr, and a loss of 32p from a plasma membrane protein identified as guanylate cyclase. here, a resact analog (125i-[tyr1, ser8] resact) was synthesized and shown to bind to isolated sperm membranes. resact, but not speract, competed with the radiolabeled ligand for binding. when membranes were prepared under appropriate conditions, guanylate cyclase remained at mr 160,000; the incubation of membranes with gamma-32p-atp resulted in the f ...	2007	2870813
[therapy of chronic heart failure with vasodilators].	the chronic heart insufficiency is essentially characterized by a disturbed regulative function of the peripheral circulation. these processes taking place within efforts for compensation close the chain of the vicious circle. the vasodilators with their different principles of effect affect in various places of the vegetative nervous system up to the smooth musculature of the vessels and modulate the peripheral part of the cardiovascular system. via a changed behaviour of the impedance also wit ...	2006	2870591
[therapy of chronic heart failure with vasodilators].	the chronic heart insufficiency is essentially characterized by a disturbed regulative function of the peripheral circulation. these processes taking place within efforts for compensation close the chain of the vicious circle. the vasodilators with their different principles of effect affect in various places of the vegetative nervous system up to the smooth musculature of the vessels and modulate the peripheral part of the cardiovascular system. via a changed behaviour of the impedance also wit ...	2006	2870591
platelet aggregation caused by carybdea rastonii toxins (crtx-i, ii and iii) obtained from a jellyfish, carybdea rastonii.	the pharmacological mechanisms of platelet aggregation induced by highly toxic proteins (crtx-i, crtx-ii, and crtx-iii) obtained from tentacles of a jellyfish, carybdea rastonii, were investigated. when the partially purified toxin (pcrtx) and crtxs were added to the citrated platelet-rich plasma (prp), aggregation was produced in a concentration-dependent manner. the activity of crtxs was approximately 100 times more potent than pcrtx. the crtxs-induced aggregation was little affected by indome ...	1986	2870502
integrating treatments in schizophrenia.	schizophrenia is a common and severe illness found throughout the world. onset is usually in adolescence and young adulthood, and many individuals have illness-related impairments for life. schizophrenia assaults the very essence of what is distinctly human. the personality is devastated, subjective experience and thought distorted, and the psychological building blocks of everyday life torn asunder. this article discusses diagnostic and conceptual considerations, pharmacotherapy, and interperso ...	1986	2870478
transglutaminase and neuronal differentiation.	during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ...	1986	2870428
transglutaminase and neuronal differentiation.	during mouse brain maturation cellular transglutaminase specific activity increases 2.5 fold from day 3 to adulthood. a more pronounced increase is seen during morphological differentiation of mouse neuroblastoma cells, where serum withdrawal induces neurite outgrowth concomitant with a 10 fold increase in transglutaminase specific activity. in contrast, non-dividing neuroblastoma cells lacking neurites show only a 1.5 fold increase in enzyme specific activity. transglutaminase activity does not ...	1986	2870428
htlv-iii antibody tests and health education.		2005	2870378
htlv-iii antibody tests and health education.		2005	2870378
multiresistant shigella dysenteriae type 1.		1985	2865444
two distinct toxins active on vero cells from escherichia coli o157.		1985	2864594
immunocytochemical studies of somatostatin neurons in brain.	immunohistochemical studies with antisera to somatostatin have, in many instances, led the way to our present understanding of the peptidergic nervous system. somatostatin was among the first of the hypophysiotropic hormones shown to be contained in diverse neuronal circuits outside of the hypothalamus. for example, somatostatin is found within neurons ranging in location from the cerebral cortex to primary sensory neurons to enteric neurons within the gut wall. somatostatin was also the first n ...	1985	2863929
multiresistant shigella infections in bangladesh.		1985	2863461
evidence against putrescine and polyamines as endogenous mediators of fever.	endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits. in addition, the febrile response to endotoxin was unaffected either by the ornithine decarboxylase inhibitor, dl-alpha-difluoromethylornithine or by putrescine. these data indicate polyamines are not involved in the development of fever.	1985	2862252
anticholinergic drugs in the treatment of airways disease.		2010	2861843
epidemic shiga bacillary dysentery in rangoon, burma, 1984/85.		1985	2861376
effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.	dietary factors can modify metabolic events involved in the initiation, promotion, or progression of tumors. to determine whether a high-sucrose diet has any effect on the development of enzyme-altered foci during the promotion step of chemical hepatocarcinogenesis in rats, 1-day-old sprague-dawley rats were given a single i.p. dose of diethylnitrosamine; controls received an equivalent i.p. volume of 0.9% nacl solution. at 21 days of age, the rats were weaned, segregated by sex, separated in gr ...	1985	2859110
effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.	dietary factors can modify metabolic events involved in the initiation, promotion, or progression of tumors. to determine whether a high-sucrose diet has any effect on the development of enzyme-altered foci during the promotion step of chemical hepatocarcinogenesis in rats, 1-day-old sprague-dawley rats were given a single i.p. dose of diethylnitrosamine; controls received an equivalent i.p. volume of 0.9% nacl solution. at 21 days of age, the rats were weaned, segregated by sex, separated in gr ...	1985	2859110
nalidixic-acid-resistant shigella dysenteriae i.		1985	2858035
consent and the young mother.		2010	2857392
court of appeals rules dhss notice on family planning contrary to law.	in the december 1982 case of gillick v. west norfolk and wisbech aha, the british court of appeal acceded to mrs. victoria gillick's petition that no professional employed by the health authority be permitted to give contraceptive or abortion treatment to any of her children under the age of 16 without her prior knowledge and consent. the ruling held that a 1980 department of health and social security notice allowing treatment of minors without parental consent was contrary to law. the court ...	1985	2856993
[effects of the long-acting analgesics 3-(beta-phenylethyl)-9 beta-methoxy-9 alpha-(m-hydroxyphenyl)-3-azabicycles [3,3,1]-nonane (p-7521) on opiate receptor binding in vitro].		1988	2855686
neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report.	we measured the concentration of neuron-specific enolase (nse) and carcinoembryonic antigen (cea) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (sclc). high levels (above 12.5 micrograms.l-1) of nse in pleural fluid were observed in five patients with sclc (sensitivity 71%). however, pleural fluid nse levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammat ...	2010	2853080
effects of carbamylcholine on membrane potential and na-k pump activity of cultured rat skeletal myotubes.	1. we measured changes in resting membrane potential (em) and na-k pump activity, assayed by ouabain-sensitive 86rb uptake, in response to carbamylcholine (cch) and its continued presence in single rat skeletal myotubes in culture. 2. cch caused immediate depolarization from control em (-80 to -85 mv) to near 0 followed by repolarization of varying degrees depending on the age of the culture and temperature of the recording medium; repolarization of em was most apparent by culture age 8-9 days i ...	1988	2852060
transfer of pre-embryos donated and fertilized in vivo to recipients given a steroid replacement therapy.	this study describes eleven procedures of non-surgical recovery of preimplantation conceptuses from the uteri of eight fertile donor women and the transfer of the recovered pre-embryos into the uteri of infertile recipients with primary ovarian failure, or with hypothalamic--pituitary failure. conjugated oestrogens and progesterone were administered to recipients as replacement steroids during the first 20 weeks of pregnancy, in order to produce a secretory endometrium allowing nidation and deve ...	2010	2851614
fatal asthma in a subject sensitized to toluene diisocyanate.	we report the case of a 43-yr-old car painter who died within 1 h of exposure to a polyurethane paint in the workplace. a diagnosis of asthma induced by toluene diisocyanate (tdi) had been established 6 yr before, when he underwent inhalation challenges with carbachol and with tdi. the subject had airway hyperresponsiveness to carbachol (pd20fev1 carbachol = 0.32 mg; normal value greater than 1.0 mg) and developed an early and long-lasting asthmatic reaction after exposure to tdi in the laborato ...	2010	2849334
pyrophosphate formation from acetyl phosphate and orthophosphate: evidence for heterogeneous catalysis.	the formation of [32p]pyrophosphate from acetyl phosphate and [32p]orthophosphate was studied under conditions in which phosphate-metal salts or acetyl phosphate-metal salts precipitate. in the absence of precipitates in purely aqueous media, the initial rate constant of transphosphorylation (kobs) was extremely small and the formation of pyrophosphate was detected only in the presence of calcium. in various combinations, conditions such as high ph, high concentrations of reactants, and the pres ...	2010	2845863
study of plasmid screening amongst pathogenic bacteria isolated in nigeria.	clinical isolates of neisseria gonorrhoeae, campylobacter jejuni, escherichia coli, shigella dysenteriae, shigella boydii, yersinia spp. and salmonella spp. were screened for the presence of plasmids. approximately 80% of these strains harboured plasmids ranging in molecular weight from 1.0 to 45 x 10(6) daltons.	1988	2845756
[computerized tomography symptoms in 2 cases of primary linitis plastica of the rectum].		2009	2844723
dna probes for shiga-like toxins i and ii and for toxin-converting bacteriophages.	a set of dna probes has been developed to study the genes for shiga-like toxins (slt) and the bacteriophage from which these toxin genes were isolated. under stringent conditions of hybridization (80 to 90% homology), these probes detect strains containing (i) slt i-related genes, (ii) slt ii-related genes, (iii) phage sequences from the slt i-converting phage h19a/933j, and (iv) phage sequences from the slt ii-converting phage 933w. strain characterization by hybridization with the toxin gene p ...	1988	2842369
[means of improving the chemoradiotherapy of small cell cancer of the lung].	the report deals with an analysis of the results of treatment of 84 patients suffering small cell lung cancer. four regimens of combination chemotherapy as well as radiation were used. complete plus partial regression rates ranged 18-81% (mean-42%) following chemotherapy and 73-87% after radiation treatment. platidiam-containing schemes proved most effective. prophylactic cranial irradiation was followed by increased survival. a correlation between extent of tumor and effectiveness of treatment ...	2008	2839938
[means of improving the chemoradiotherapy of small cell cancer of the lung].	the report deals with an analysis of the results of treatment of 84 patients suffering small cell lung cancer. four regimens of combination chemotherapy as well as radiation were used. complete plus partial regression rates ranged 18-81% (mean-42%) following chemotherapy and 73-87% after radiation treatment. platidiam-containing schemes proved most effective. prophylactic cranial irradiation was followed by increased survival. a correlation between extent of tumor and effectiveness of treatment ...	2008	2839938
[position of surveillance therapy in clinical stage i testicular non-seminoma].	since the initiation of a 'surveillance' therapy the role of retroperitoneal lymph node dissection as standard treatment in the management of patients with clinical stage i nonseminomatous germ cell testicular tumor (nsgctt) continues to be debated. noninvasive staging techniques (ct scans, lymphography, ultrasound and serologic tumor markers) help to identify more accurately patients with distant metastases. 'surveillance' alone as a possible treatment modality following orchidectomy in selecte ...	2010	2834854
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.	insulin receptor complementary dna has been cloned from an insulin-resistant patient with leprechaunism whose receptors exhibited multiple abnormalities in insulin binding. the patient is a compound heterozygote, having inherited two different mutant alleles of the insulin receptor gene. one allele contains a missense mutation encoding the substitution of glutamic acid for lysine at position 460 in the alpha subunit of the receptor. the second allele has a nonsense mutation causing premature cha ...	1988	2834824
nmr contrast agents for proton imaging.		2010	2832350
three distinct forms of type 2a protein phosphatase in human erythrocyte cytosol.	two type 2a protein phosphatases, phosphatases i (mr = 180,000) and iii (mr = 177,000), were purified to near homogeneity from human erythrocyte cytosol. phosphatase i was composed of alpha (34 kda), beta (63 kda), and delta (74 kda) subunits in a ratio of 1:1:1. phosphatase iii comprised alpha, beta, and gamma (53 kda) subunits in the same ratio. heparin-sepharose column chromatography converted most of phosphatase i and 20% of phosphatase iii into alpha 1 beta 1 which were indistinguishable fr ...	1988	2831201
generation and recognition of leukotriene mediators of hypersensitivity and inflammation.	the potent mediators generated by the 5- and 15-lipoxygenation of arachidonic acid have diverse effects on smooth muscles, blood vessels, leukocytes, epithelial cells and glands, and sensory neurons, which suggest possible roles in the initiation and regulation of physiological and biochemical events. the responses to leukotrienes and related mediators are attributable to binding by stereospecific cellular receptors and consequent activation of biochemical transductional sequences analogous to t ...	2010	2831014
transposon-induced alterations in the promoter region affect transcription of the chalcone synthase gene of antirrhinum majus.	four solid-colour revertants were isolated from the highly variegated niv-53::tam1 mutant, in which the transposable element tam1 is integrated in the promoter region of the chalcone synthase (chs) gene. dna sequence analysis revealed that in all four lines the tam1 element was deleted together with flanking nucleotides of the chs promoter. in one case the tata box of the chs gene was removed resulting in extremely low expression of the gene, and initiation of transcription occurring at a new po ...	1988	2830468
cloning and sequencing of the genes for shiga toxin from shigella dysenteriae type 1.	the structural genes for shiga toxin, designated stx a and stx b, were cloned from shigella dysenteriae type 1 3818t, and a nucleotide sequence analysis was performed. both stx a and stx b were present on a single transcriptional unit, with stx a preceding stx b. the molecular weight calculated for the processed a subunit was 32,225, while the molecular weight of the processed b subunit was 7,691. comparison of the nucleotide sequences for shiga toxin and shiga-like toxin i (slt-i) from escheric ...	1988	2830229
limb specific connections of the cat magnocellular red nucleus.	afferent and efferent connections of the limb specific divisions of the cat magnocellular red nucleus (rnm) were traced using the bidirectional transport of wheatgerm agglutinin-horseradish peroxidase complex (wga-hrp). injection sites within forelimb or hindlimb rnm regions were identified by microelectrode recording and confirmed by the position of labeled rubrospinal terminals. additional injections into structures that project to, or receive input from, rnm confirmed the somatotopic organiza ...	1987	2826551
[reflections on 851 open heart operations at the institute of cardiology in abidjan].		2010	2826086
the versatility of hydroxyapatite blocks in maxillofacial surgery.	there is considerable interest at present in the potential role of calcium hydroxyapatite as a biomaterial for bone augmentation in oral and maxillofacial surgery. most of the published work has been on the particulate form, mainly in alveolar ridge procedures. however, hydroxyapatite is also available as solid or porous blocks. the blocks are more predictable in their use than are the particles, and are adaptable and versatile. this paper reviews the biological behaviour of the material and dis ...	2010	2825758
redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.	infection of human epidermoid carcinoma no. 2 cells with herpes simplex virus type 1 (hsv-1) leads to a reorganization of antigens associated with both the small and heterogeneous nuclear ribonucleoprotein complexes (snrnp and hnrnp). the hnrnp core protein antigens remain associated with the host chromatin, which appears to collapse into internal aggregates and along the nuclear envelope. more striking is the formation of prominent clusters of snrnp antigens (both general and u1 snrnp specific) ...	1987	2824525
pharmacokinetics of adriamycin, adriamycinol, and antipyrine in patients with moderate tumor involvement of the liver.	the pharmacokinetics of adriamycin, its metabolite adriamycinol, and antipyrine were studied in 17 patients with moderate tumor involvement of the liver and compared to that of 19 tumor patients with normal liver function (preiss et al. 1985). the individual liver function parameters deviated from normal by a factor ranging from 2.5 to 12.2. the t1/2 alpha and t1/2 beta, the auc (corrected for body weight and dose) and the total body clearance (cl, corrected for body weight) of adriamycin did no ...	2010	2824523
the primary care role in occupational health nursing.	primary care is a valid, legal responsibility of the practicing occupational health nurse and accounts for a high percentage of the occupational health nurse's daily activities when considered on a local, national, and international level. historically, the varying definitions of primary care presented have led to confusion among practitioners who are attempting to categorize their services. the author attempts to express a workable interrelationship among these numerous terms including, "primar ...	2009	2818762
[characteristics of the course of the gestation period in patients with solitary kidney].	clinical biochemical, bacteriological investigations and functional tests were performed in 37 pregnant females with a solitary kidney. the status of fetoplacental system was studied as well. the investigators noted such common complications of pregnancy as the aggravation of renal inflammation, a high rate of caesarean section and postnatal morbidity. it was concluded that in case of pyelonephritic affection a solitary kidney the pregnancy should be terminated. if the infection was absent and t ...	2009	2817278
[family dynamics of psychosocially disturbed adolescents].	using a personality centered method psycho-socially disturbed adolescents aged between 17 and 22 years were treated by the intended dynamic group psychotherapy. an attempt was made to include the family in the care, which succeeded in 2/3 of the cases. the observations of the family dynamics are presented as follows: 1. a description of the dependence behaviour; 2. a phenomenologic description of disintegrating or rigid family structures; 3. the significance for therapeutic aims and prognosis is ...	2008	2816551
[development of partner relations in very young mothers].	a study was made on the development of partner relationships among adolescent mothers over a period of two years from the day of delivery onwards. from ascertained that there was still "definite marriage intention" or that the partners were interviewed at the maternity ward of the rostock county hospital and their data was compared with that of a control group of primiparae mothers (delivery age: 20-22y.). 73% of the partnerships of adolescent mothers with the child's father that existed at the ...	2008	2816549
the renal phosphate transport defect in normal mice parabiosed to x-linked hypophosphatemic mice persists after parathyroidectomy.	the x-linked hypophosphatemic (hyp) mouse is a model for human x-linked hypophosphatemia. surgical joining of normal to hyp mice by parabiosis results in the normal mice developing low renal retention of phosphate and hypophosphatemia. these results suggest a humoral component to the renal defect. to test whether this component could be parathyroid hormone, surgical parathyroidectomy (ptx) or sham surgery was performed in mice 3 weeks after parabiotic union (n greater than 20 per group). after a ...	1989	2816501
role of schwann cells in periaxonal ion regulation in the squid.		2006	2816437
role of schwann cells in periaxonal ion regulation in the squid.		2006	2816437
is a rise in [ca]1 responsible for rapid changes in neuronal excitability, ca currents, extracellular ions and ph0 induced by brief anoxia?		2006	2816423
is a rise in [ca]1 responsible for rapid changes in neuronal excitability, ca currents, extracellular ions and ph0 induced by brief anoxia?		2006	2816423
sex- and age-related changes in catecholamine metabolism and release of rat adrenal gland.	to examine the possible existence of changes in the adrenal catecholaminergic activity during aging, we analyzed the adrenal content of catecholamines (ca) and the activities of selected enzymes involved in their metabolism as well as the basal and the k+-stimulated release of these ca in incubated adrenal tissue of aged (greater than 22 months) and young (2 months) rats of both sexes. adrenal contents of norepinephrine (ne) and epinephrine (e) of male rats were unaltered in aging, although aged ...	1989	2812194
sex- and age-related changes in catecholamine metabolism and release of rat adrenal gland.	to examine the possible existence of changes in the adrenal catecholaminergic activity during aging, we analyzed the adrenal content of catecholamines (ca) and the activities of selected enzymes involved in their metabolism as well as the basal and the k+-stimulated release of these ca in incubated adrenal tissue of aged (greater than 22 months) and young (2 months) rats of both sexes. adrenal contents of norepinephrine (ne) and epinephrine (e) of male rats were unaltered in aging, although aged ...	1989	2812194
carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. occurrence of complex-type sugar chains with the gal beta 1----3glcnac beta 1----3gal beta 1----4glcnac beta 1----outer chains.	nonspecific cross-reacting antigen-2 (nca-2) is a glycoprotein purified from meconium as a closely correlated entity with carcinoembryonic antigen (cea). as in the case of cea, only asparagine-linked sugar chains are included in nca-2. in order to elucidate the structural characteristics of the sugar chains of nca-2, they were quantitatively released from the polypeptide backbone by hydrazinolysis and reduced with nab3h4 after n-acetylation. the radioactive oligosaccharides were fractionated by ...	2010	2808357
purification of shiga toxin and shiga-like toxins i and ii by receptor analog affinity chromatography with immobilized p1 glycoprotein and production of cross-reactive monoclonal antibodies.	shiga toxin from shigella dysenteriae 60r was purified to homogeneity by a novel one-step receptor analog affinity chromatography method. the method was based on the binding affinity of shiga toxin for a specific disaccharide, gal alpha 1----4gal, which was also present in glycoproteins with p1 blood group seroreactivity produced in hydatid cysts from sheep infected with echinococcus granulosus. having shown that cyst fluid p1 glycoprotein bound shiga toxin on a solid phase, a p1 glycoprotein af ...	1989	2807552
experimental studies on membrane permeability defects of drug-resistant bacteria.	multiply antibiotic-, lysozyme-and bacitracin-resistant, representative strains of staphylococci, escherichia coli, shigella dysenteriae and klebsiella pneumoniae were compared respectively with their parent cultures in respect of their membrane permeability as judged by fluorescence polarization spectroscopy, using a sensitive fluorescent probe. the cytoplasmic membrane of the drug-resistant mutants was found to be less fluid and permeable, compared to that from the sensitive wild types. the st ...	1989	2807429
cognitive and social-emotional development of children in different preschool environments.	62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ...	2009	2798666
cognitive and social-emotional development of children in different preschool environments.	62 english-speaking preschool children were divided into three groups, a montessori group (n = 21), a traditional preschool group (n = 21), and a homestaying group (n = 20) to compare their relative cognitive and social-emotional development. significant differences in favour of the school groups were found for vocabulary, language comprehension, ability to judge the correctness of figural stimuli, visual memory, and perceptual organization. no differences were found for social-emotional develop ...	2009	2798666
rapprochement and other crises. the specific and nonspecific in analytic reconstruction.	the historical development of preoedipality in evolving psychoanalytic theory is traced. particular reference is paid to the elaboration by mahler of the separation-individuation phase and the specific rapprochement conflict and crisis within it. in addition to the valuable contributions these discoveries have brought about, the tendency is noted for every new locus of interest to be obscured by excessive claims, and distorted by overuse and reductionism to explain complex and multidetermined be ...	2002	2798609
31p-nmr study on intracellular energy transport in muscle.		2009	2798486
31p-nmr study on intracellular energy transport in muscle.		2009	2798486
[osteolytic foci: cancer or not?].		2009	2797229
detoxification of lithocholic acid. elucidation of the pathways of oxidative metabolism in rat liver microsomes.	the hydroxylation of lithocholic acid (3 alpha-hydroxy-5 beta-cholanoic acid) by adult male sprague-dawley rat liver microsomes supplemented with nadph was studied. metabolites were separated by a combination of thin-layer chromatography and high pressure liquid chromatography, both with and without prior methylation and acetylation of the samples. the resulting products were characterized by thin-layer, gas-liquid, and high pressure liquid chromatography by comparison with authentic bile acid s ...	1989	2794781
spinal chronic subdural haematoma in a 7-year old girl.	a case is reported of chronic encapsulated spinal subdural haematoma which developed in a 7-year-old girl after minor spinal trauma. surgical removal of the lesion was followed by complete recovery.	2009	2792133
intrahepatic lesions demonstrated to be hemangiomas after a ten-year lapse.		2003	2791431
[clinical significance of the quantification of obesity. the quetelet index and its use].	the degree of obesity, ie. the quantity of excessive stored adipose tissue, affects substantially morbidity and mortality on cardiovascular, metabolic, and other diseases. while the quantity of an adipose tissue is practically impossible to determine, it is necessary to use the body weight, adjusted for the stature. the quetelet's index (body mass index, bmi) is the best one from height-weight indices. values of bmi define categories of normal weight, overweight, and obesity, which have differen ...	2009	2790909
regional pain syndrome.		2009	2790410
[coagulation and fibrinolytic system of macrophages].		2009	2786578
[intraoperative management of emergency coronary artery bypass grafting].	intraoperative hemodynamics during emergency coronary artery bypass grafting (cabg) for acute evolving myocardial infarction (26 cases) were measured and compared with those during elective cabg (39 cases). before cardiopulmonary bypass period, it was strongly suggested that the cardiac function of emergency cases was worse than that of elective cases because of the following 5 factors; (1) hypotension, (2) tachycardia, (3) low stroke volume index, (4) pulmonary congestion and (5) metabolic acid ...	2009	2786576
structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity. ii. evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of mptp analogs.	in the accompanying paper, several tetrahydropyridine analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) were screened for their abilities to be oxidized by monoamine oxidase (mao) to pyridiniums and to produce neurotoxicity in mice. we reported that most of the analogs were oxidized by mao to pyridiniums and some of the analogs were neurotoxic. we concluded that the capacity of a tetrahydropyridine mptp analog to be oxidized by mao to a pyridinium was a necessary, but not sufficient ...	2009	2786565
aging effects on secretory iga immune responses.	studies of cellular and humoral components of the secretory immune system indicated dramatic decreases in the siga response to t-dependent antigens (i.e. dnp-bgg) in aged rats. senescent rats (18-20 months old) showed comparable levels of siga anti-dnp antibody to adult animals after oral immunization with a t-independent antigen, dnp-ficoll. the salivary siga responses to both antigens were substantially decreased in weanling rats (21-35 days) versus the adult rats. significant anamnestic siga ...	1989	2786502
investigations of the potential for five beta-lactam antibiotics to elicit type ii hypersensitivity reactions in rats and monkeys.	immunologic reactions are occasionally elicited in patients by various beta-lactam antibiotics (e.g., penicillins and cephalosporins). a relatively rare reaction (type ii hypersensitivity) may involve antibody-mediated destruction of erythrocytes, leukocytes, and/or platelets. during the safety evaluation of several modified beta-lactam compounds (carbapenems), hemolytic anemia and/or neutropenia were observed in rhesus monkeys, and anemia, neutropenia, and thrombocytopenia in rats, after approx ...	1989	2786479
lymphokine-activated killer (lak) cells inhibit the clonogenic growth of human leukemic stem cells.	the effect of lymphokine-activated killer (lak) cells on the in vitro clonogenic capacity of acute myeloid leukemia (aml) blasts was investigated in a semisolid medium assay. the leukemic clonogenic capacity of 11 aml cases, selected on the basis of their ability to grow in vitro, was highly reduced following overnight preincubation with lak effectors. the degree of colony inhibition, which ranged between 66% and 98% (mean 83.8% +/- 11.4 sd), was quantitatively greater than by 51cr release, whic ...	1989	2786477
co-localization of corticotropin-releasing factor- and enkephalin-like immunoreactivities in nerve cells of the rat hypothalamus and adjacent areas.	the co-localization of corticotropin-releasing factor (crf)- and enkephalin (enk)-like immunoreactivities in nerve cells of the rat hypothalamus and adjacent areas was investigated by the simultaneous application of immuno-beta-galactosidase staining and the peroxidase-antiperoxidase (pap) method to the same sections. crf-like immunoreactive cells were stained blue with immuno-beta-galactosidase staining and enk-like immunoreactive cells brown with the pap method. double-labeled cells with overl ...	1989	2786446
neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type a.	moclobemide belongs to a new generation of short-acting, reversible, monoamine oxidase (mao) inhibitors. in vitro (rat brain homogenates) moclobemide inhibits mao-a selectively with lower potency than many of the reference mao inhibitors. however, when measured ex vivo in the rat, the potency of moclobemide is similar to that of reference compounds. in vivo the drug induces a dose-dependent, short-lasting (8-16 hr) and preferential inhibition of mao-a in the brain and both mao-a and mao-b inhibi ...	1989	2783611
neurochemical profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type a.	moclobemide belongs to a new generation of short-acting, reversible, monoamine oxidase (mao) inhibitors. in vitro (rat brain homogenates) moclobemide inhibits mao-a selectively with lower potency than many of the reference mao inhibitors. however, when measured ex vivo in the rat, the potency of moclobemide is similar to that of reference compounds. in vivo the drug induces a dose-dependent, short-lasting (8-16 hr) and preferential inhibition of mao-a in the brain and both mao-a and mao-b inhibi ...	1989	2783611
a strategy for high-volume sequencing of cosmid dnas: random and directed priming with a library of oligonucleotides.	direct sequencing of cosmid dnas using a library of oligonucleotide primers of length 8, 9, or 10 is proposed. the statistics of priming indicate that a primer library sufficient for determining the sequence of the entire human genome (100,000 cosmids) would be small enough to be assembled and managed. such a library would greatly reduce the cost and effort of high-volume sequencing: primers would be instantly available; the sequence of each cosmid dna could be determined from a single dna prepa ...	1989	2780548
[glycogenosis type ii (pompe's disease) in a 6-month-old child].		2007	2780149
twenty-year comparison of the human allograft and porcine xenograft.	this study compares a retrospective consecutive series of human allografts and concurrent porcine xenografts implanted over a 10-year interval. there were 571 allograft valves and 1,351 xenograft valves implanted in the aortic and mitral position with mean follow-up of 12.8 years for the allografts and 6.2 years for the xenografts. this study compares the incidence of structural deterioration over long-term follow-up. we found that there was no significant difference between four manufacturers o ...	1989	2774760
[the importance of physiopathology in the management of peptic ulcer].		2009	2772478
community care--up in the air?		2009	2771747
determination of estradiol 2- and 16-alpha-hydroxylase activities in mcf-7 human breast cancer cells in culture using radiometric analysis.	using a radiometric assay the effects of estradiol upon the activity of estradiol 2- and 16 alpha-hydroxylases in mcf-7 human breast cancer cells in culture were studied. after 5 days of treatment and 36 h of withdrawal, incubation in the presence of either 2- or 16 alpha-tritiated substrate was carried out. estradiol (10 nm) significantly increased 16 alpha-hydroxylase activity (21%, p less than 0.01), while no effects on 2-hydroxylase activity was observed. treatment for 6 weeks caused a major ...	1989	2770303
convergence to stationary distributions in two-species stochastic competition models.	two sets of sufficient conditions are given for convergence to stationary distributions, for some general models of two species competing in a randomly varying environment. the models are nonlinear stochastic difference equations which define markov chains. one set of sufficient conditions involves strong continuity and phi-irreducibility of the transition probability for the chain. the second set has a much weaker irreducibility condition, but is only applicable to monotonic models. the results ...	2009	2769087
car radiator burns: a report on 72 cases.	seventy-two cases of car radiator burns (crb) were treated in the burns unit, hamad medical corporation, doha, qatar, over a 6-year period (1982-87). all the patients were males and most were between 20 and 40 years old. chest wall, face and right upper limb were the commonest sites involved. most of the patients suffered from relatively minor scalds. the scenario of the accidents as well as the topography of the burned areas were characteristic to this particular type of injury. the exceptional ...	2009	2765150
[infection caused by paracoccidioides brasiliensis in people living in cocle and veraguas, republic of panamá].	intradermal application of yeast phase paracoccidioidin antigen obtained by sonication and lysis from the fungus to 111 residents of veraguas province (68 men and 43 women) and 130 cocle province residents (57 men and 73 women) elicited a positive reaction in 9.01% (1/111) and 26.15% (34/30) of the veraguas and cocle residents respectively. positive reactions ranged between papules of 5 and 27 mm in diameter, the majority being between 11 and 20 mm. infection was more frequent in men (1:1.47 for ...	1989	2762594
relationship between concentration and anticonvulsant effect of phenytoin against electroshock-induced seizures in rats: comparison of sampling sites for concentration determinations.	the purpose of this investigation was to determine the optimum sampling site for phenytoin concentration measurements in the context of pharmacodynamic studies of the anticonvulsant effect of phenytoin. determination of drug concentrations in the serum, serum water, brain, and cerebrospinal fluid (csf) of rats as a function of time after iv injection of a 6-mg/kg dose revealed a significant disequilibrium between brain and serum water for 15 min and between csf and serum water for 5 min after in ...	1989	2760817
perioral anesthesia disrupts maternal behavior during early lactation in long-evans rats.	the role of perioral somatosensory stimulation from pups in maternal behavior was investigated in lactating long-evans rats (rattus norvegicus) during early lactation by local anesthesia of the mystacial pads with lidocaine, which blocks conduction in the infraorbital nerve. it was concluded that (1) acute perioral anesthesia markedly inhibited pup retrieval when the subjects had no formal pretreatment retrieval experience. further, these dams displayed little tolerance to the lidocaine treatmen ...	1989	2757582
who issues report on heavy metal and pah compounds from municipal incinerators.		2009	2754439
a ruptured cerebral aneurysm from choriocarcinomatous origin--a case report and a review.	a case of a ruptured metastatic aneurysm of choriocarcinoma is reported. the fourteen other cases of the literature are summarized. the pathological significance of this rare presentation of metastatic disease is discussed. the treatment of choice is defined as excision followed by chemotherapy and whole brain irradiation. the prognosis remains poor.	2009	2747937
synaptic cytoarchitecture of the cat septum pellucidum.		1989	2747886
dislocated jaw.		2009	2742562
[use of the polymorphism of flanking dna probes with respect to the xq-27 region in a great fragile x pedigree].	we analyzed the segregation between fragile site xq 27 and flanking polymorphic probes (52a, for factor 9, 4d-8, for factor 8, st14 and mn12) in a great xq-fra pedigree. on the basis of these data, the use of these probes is discussed in view of its value as a diagnostic tool.	2008	2740689