Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the relative distribution of thyroxine, triiodothyronine and 3,3',5'-(reverse)-triiodothyronine in various fractions of thyroglobulin. | thyroglobulin fractions rich and poor in new thyroglobulin were separated by means of deae-cellulose chromatography of dog thyroid extracts and by zonal ultracentrifugation in a sucrose gradient of guinea pig thyroid extract incubated at low temperature. the distrubtion of thyroxine, triiodothyronine and 3,3',5'-(reverse)-triidothyronine in hydrolysates of the different fractions was estimated by radioimmunoassays. following deae-cellulose chromatography there was a small but statistically signi ... | 1978 | 580831 |
| thyroxine: studies concerning its intrinsic physiological activity. | the importance of the monodeiodination of t4 to t3 in the physiological action of t4 was explored by assessing the role of t4 in maintaining prophylthiouracil (ptu)-treated rats during exposure to 4 degrees c. (ptu inhibits both thyroid hormone biosynthesis and t4 to t3 conversion in peripheral tissues.) firstly, the effects of cold exposure on the metabolism of t4 in control and ptu-treated rats equilibrated with [125i]t4 (2 microgram/100 g b. w./day) were determined. ptu was administered in th ... | 1978 | 580539 |
| thyroid hormone formation in ectopic thyroid gland. a case study. | several steps of thyroid hormogenesis were studied on a subhyoid ectopic thyroid tissue in a case of compensated hypothyroidism with simultaneous sublingual and subhyoid ectopic thyroid. the patient, a 19-year-old girl, had normal values for serum t4, t3u and t3, and an elevated serum tsh level. the thyroidal 131i uptake was elevated both at 3 h and 24 h after oral 131i intake. no significant discharge of radioiodine was observed after perchlorate load. on the thyroid biopsy specimen, peroxidase ... | 1978 | 580519 |
| chemical determination of iodinated compounds in human thyroid. | as a tool with which to detect iodinated compounds in human thyroid specimens, we have reevaluated a nonincineration technique which has so far been employed in the determination of thyroxine-iodine in peripheral blood. the catalytic action of iodoamino acids in the ce-as reaction was enhanced by a small amount of cl2. on the contrary, a large amount of cl2 inhibited the reaction unexpectedly. among iodide, iodotyrosine and iodothyronine, iodide was the most effective catalyst in the ce-as react ... | 1978 | 580417 |
| correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with graves' disease and subacute thyroiditis. | serum thyroglobulin (tg), triiodothyronine (t3), and thyroxine (t4) concentrations were measured in sera from selected patients with hyperthyroidism due to graves' disease and with subacute thyroiditis. in agreement with previous reports, the concentration of serum tg was elevated in untreated hyperthyroidism due to graves' disease, being 132 +/- 124 ng/ml (mean +/- sd) as opposed to 11 +/- 6.4 ng/ml in normal subjects. during treatment of hyperthyroidism with antithyroid drugs with or without i ... | 1978 | 580305 |
| inappropriate triiodothyronine (t3) and thyroxine (t4) radioimmunoassay levels secondary to circulating thyroid hormone autoantibodies. | 1978 | 580230 | |
| iodoamino acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation. | the distribution of iodotyrosines and iodothyroinines has been studied in poorly iodinated 19 s thyroglobulins isolated by sucrose gradient centrifugation from five human thyroid tissue. the 19 s thyroglobulins have been fractionated by isopycnic centrifugation and 34.5% rubidium chloride gradient. the distribution of iodoamino acids depends on the total iodine content of each fraction. the variations in mit) and dit residues with increasing levels of iodination are not identical, the elevation ... | 1978 | 580134 |
| the relationship of thyroid-stimulating hormone (tsh), thyroxine (t4), and triiodothyronine (t3) in primary thyroid failure. | thyroid-stimulating hormone (tsh), serum thyroxine (t4) and triiodothyronine (t3) in sera of 100 patients with primary thyroid failure were measured by radioimmunoassay. effective thyroxine ratio (etr) was also measured in 69 of these sera. tsh was elevated in all, with a mean of 76.7 +/- 55 micromicron/ml (range 11 to 140 micromicron/ml, and was used to confirm the diagnosis. mean t4 and t3 levels in the group were 1.8 +/- 1.5 microgram/100 ml (range less than 0.2 to 7.0 microgram/100 u.) and 7 ... | 1977 | 579717 |
| opposite variations in serum t3 and reverse t3 during propylthiouracil treatment of thyrotoxicosis. | blood samples for determination of serum total and free reverse triiodothyronine (rt3), triiodothyronine (t3) and thyroxine (t4) were obtained daily in 6 previously untreated thyrotoxic patients during periods of propylthiourazil (ptu) (600 mg per day) or methimazol (mmi) (45 mg per day) administration. ptu induced about 60 per cent increase in both total and free serum rt3. this was accompanied by a rapid decrease in serum t3 and a more gradual decline in serum t4. mmi administration to untreat ... | 1978 | 579537 |
| correlation between per cent discharge of thiocyanate test and thyroid functions in patients with hashimoto's disease. | the thiocyanate test was carried out in 18 patients with hashimoto's disease. thiocyanate was given orally several hours after the administration of tracer doses of 131i when the thyroid counts seemed to have reached a plateau. the per cent discharge of thiocyanate test was significantly higher in the groups with lower level of t4 (less than 5.5 microgram/100 ml), rsh (less than 25.5%) and bmr (less than +2.5%), and higher levels of tsh (greater than 10.0 muu/ml). a chi-square (chi2) test with y ... | 1978 | 579536 |
| effects of experimental hypothyroidism on skeletal muscle metabolism in the rat. | hind-limb perfusion was used to study the effect of thyroidectomy on some metabolic parameters in the skeletal muscle of the rat. a week after thyroidectomy obtained by one dose of 3/4 mci 131i, neither t4 nor t3 was detected in the blood. lactate production and glycerol production were already decreased a week after the treatment and reached a base level at two weeks. at that time, the oxygen consumption was significantly lower (70% of initial level) than in the control animals and decreased fu ... | 1978 | 579526 |
| changes in serum tsh and t4 after t3 suppression tests in patients treated for hyperthyroidism due to graves' disease. | 1977 | 579181 | |
| the influence of hypophysectomy on nsila concentrations in the dog: evidence for partially pituitary-independent regulation. | non-suppressible insulin-like activity (nsila) was determined in 5 dogs before and after hypophysectomy. all nsila determinations were carried out on serum samples after acidic sephadex g-50 chromatography by two different assay systems, i.e. a bioassay and a protein binding assay. the levels of nsila decreased significantly after hypophysectomy and returned to near normal levels after 2 weeks. t3-, t4- and cortisol levels were drastically reduced during the entire period of the experiment. seve ... | 1977 | 579020 |
| the thyroid reserve in patients with breast cancer. | patients with breast cancer were studied with regard to changes in the levels of serum thyroxine (t4) and serum triidothyronine (t3) after intramuscular administration of tsh for three days to investigate the thyroid reserve in these patients. the changes were examined also in normal subjects, in patients with hashimoto's thyroiditis and primary hypothyroidism. in primary hypothyroidism no increase was seen in serum t4 and t3 levels after tsh administration, and the thyroid reserve was considere ... | 1977 | 579003 |
| [radioimmunoassay of thyroxine by t4-riapac (author's transl)]. | 1977 | 578994 | |
| [determination of thyroxine by t4-riapac and seralute t4-ria kits (author's transl)]. | 1977 | 578961 | |
| [investigation of measurement method for serum thyroxine (t4) by radioimmunoassay using polyethyleneglycol (peg) (author's transl)]. | 1977 | 578947 | |
| studies on circadian variations of plasma tsh, thyroxine and triiodothyronine in man. | to evaluate the existence of circadian variations in thyroid hormone and tsh levels, blood was drawn every 20 min for 24 h in four and for 14 h in one volunteer. hormones were measured by sensitive radioimmunoassays. tsh: a diurnal rhythmicity could be demonstrated with peaks from 8 p.m. to 2 a.m and a nadir from 7 a.m. to 2 p.m. superimposed on the diurnal rhythm multiple shortlived fluctuations were observed. thyroxine: pooled data showed peak values from 8 a.m. to 12 a.m. and lowest levels fr ... | 1977 | 578614 |
| [plasmatic thyroid hormones during treatment of hyperthyroidism by carbimazol (author's transl)]. | plasmatic concentrations of thyroxine (t4-d-) and triiodothyronine (t3 ri) were evaluated in 32 graves' diseases on treatment by carbimazol. among 131 measures, t4 and t3 were dissociated in 56%, with t3 more elevated than t4 in 89%. compensated hypothyroidism was frequently seen (35%). | 1977 | 578398 |
| t3 toxicosis in children. | triiodothyronine (t3) toxicity has been well documented in adults, but only isolated cases have been reported in children. two girls presented with firm goitres and overt hyperthyroidism. in each patient, total serum thyroxine (t4) values by competitive protein binding were normal, however total t3 values by radioimmunoassay were elevated. one patient had graves' disease, the second patient had hashimoto's disease which has been only infrequently associated with t3 toxicity in adults. both patie ... | 1977 | 578375 |
| [evaluation and clinical application of a new commercial radioimmunoassay kit for serum thyroxine (total t4 (ria), ames company). (author's transl)]. | 1977 | 578325 | |
| reduction of plasma triiodothyronine (t3) induced by propranolol. | the effect of propranolol on plasma triiodothyronine (t3), thyroxine (t4) and triiodothyronine uptake by sephadex g-25 (rt3u%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum t3 which began 60 min after administration. no significant changes were observed in t4 and rt3u% values. plasma t3 levels remained suppressed during a 5 day course of treatment with propranolol. these results sugg ... | 1977 | 577897 |
| thyroxine toxicosis in patients with iodine induced thyrotoxicosis. | serum concentrations of thyroxine (t4) and triiodothyronine (t3) were measured in 74 untreated hyperthyroid patients. of these, 47 had graves' disease, 12 had toxic nodular goiter and 15 had iodine induced thyrotoxicosis (iit). the average serum t4 concentrations were, respectively, 13.5 microgram/100 ml and 13.3 microgram/100 ml (normal 4.5-10.3 microgram/100 ml). the average serum t3 concentrations were in the same order 732 ng/100 ml, 505 ng/100 ml and 378 ng/100 ml )normal 116-288 ng/100 ml) ... | 1977 | 577497 |
| rapid disappearance of loading doses of thyroxine from blood and their excretion by the bile in rats. | the disappearance of loading doses of thyroxine (t4) (100-20 000 microng t4 iv per rat weighing about 400 g) was measured with the aid of new technique allowing frequent blood sampling with maintenance of isovolaemia in anaesthetized animals. it was found that as early as 2 min after the injection more than half of the administered dose disappeared from the blood, while after 300 min only about 2% of that remained in the plasma. the direct relationship between the administered dose of t4 and bot ... | 1977 | 577338 |
| stimulation of peripheral t3 formation by oral but not by intravenous glucose administration in fasted subjects. | fasting is known to promote a shift in the conversion of thyroxine (t4), more being deiodinated to an inactive form, reverse triiodothyronine (rt3), and less to active triiodothyronine (t3). the mechanism behind this change is not known, but it has recently been demonstrated that the proportion of dietary carbohydrates influences the serum concentration of t3 and rt3. therefore, it is possible that the deiodination of t4 is subordinated to gastroenterohepatic regulation. to explore this possibil ... | 1977 | 577337 |
| reversible plasma and red blood cells volumes increases in acromegaly. | plasma volume (pv) and red blood cells volume (rbcv) were measured in 76 normotensive acromegalic patients (42 males and 34 females) and compared with those of 28 controls on the basis of body surface. in untreated males pv and rbcv were significantly higher than in normals (p less than 0.001) and total blood volume (tbv) was above the normal range in 85%. untreated females also showed an elevated pv but had significantly lower rbcv than the male patients. the only vascular volume of the patient ... | 1977 | 577334 |
| in vivo studies on thyroxine and triiodothyronine metabolism in the rat. | the reciprocal effects of loading amounts of thyroxine (t4) or triiodothyronine (t3) on the in vivo deiodination of their 125i-labelled isotopes by the rat were studied. it was found that the deiodination of a tracer amount of [125i]t3 as measured by the 24-h urinary 125iodide was significantly decreased after administration of a loading dose of non-radioactive t4. a similar decrease in deiodination of [125i]t3 was observed following the injection of a t3 load. in experiments in which the deiodi ... | 1977 | 577327 |
| divergent effects of 6-propylthiouracil on 3,3',5'-triiodothyronine (rt3) serum levels and in man. | the effect of 6-propylthiouracil (ptu) on the peripheral conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3 rt3) was investigated by assessments of the concentrations of t4 t3 and rt3 in peripheral venous blood from t4-treated healthy volunteers given ptu, 4 x 150 mg daily. within on day of ptu administration, serum t3 concentrations were reduced, and those of rt3 enhanced. these deviations lasted as long as ptu was given (five days), and there ... | 1977 | 577326 |
| thyroid hormone-binding interactions in cytosol of rat anterior pituitary. | thyroxine (t4) and triiodothyronine (t3)-binding interactions in preparations of rat anterior pituitary gland have been studied. t4 is bound primarily to extranulcear binding sites located in the cytosol fraction of the cell. these sites have a medium affinity for t4: ka = 2.5 x 10(8) 1/mol and a maximum binding capacity (mbc) of 1.15 pmol/mg tissue (wet weight). binding of t3 to these sites is minimal. the extent of binding of t4 is influenced by the ph of the system and the temperature of incu ... | 1977 | 577324 |
| transplantable thyroid tumour in rats: iodoamino acid distribution in successive tumour generations. | all first generation thyroid tumours in rats, produced by 3 micronc 131i followed by lid, were uniformly functional containing mit, dit, t4, t3, and in some cases, t'3. all fourth generation tumours were nonfunctional as tested. second and third generation tumours were biochemically unpredictable, some containing all iaa including t'3, others only mit, i-and a trace dit. degree of dedifferentiation and of autonomy did not necessarily correlate with loss of function. results could be explained by ... | 1977 | 577083 |
| influence of experimental hyperthyroidism on skeletal muscle metabolism in the rat. | in this study hind-limb perfusion was used to investigate the influence of thyroid hormones on some metabolic parameters in the skeletal muscle of the rat. daily injection of 20 microng l-thyroxine (t4) per 100 g b. w. for a week caused a 25% increase in oxygen consumption. further enlargement of the t4 dose had little additive effect. in the dose range 20--80 microng t4/100g b.w., no important changes occurred in lactate production or glucose consumption. only at the highest t4 dose did the glu ... | 1977 | 577081 |
| value of simultaneous t3, t4, and tsh measurements for management of graves' disease in children. | one hundred simultaneous determinations of serum t4 and t3 were performed during the course of treatment of 23 children and adolescents with graves' disease. five patients were previously untreated and six were experiencing relapse after treatment was discontinued. during relapse, increased t3 concentration is frequently present when serum t4 concentration is normal and t3 measurement is therefore more reliable for early detection of relapse. during therapy with thionamides, t4 measurement alone ... | 1977 | 577011 |
| plasma thyroxine, 3,3',5-triiodothyronine and 3,3',5'-triiodothyronine during beta-adrenergic blockade in hyperthyroidism. | plasma thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) were measured in 16 patients with graves' disease. patients were studied under the following conditions: first without any treatment, then, during beta-adrenergic blockade with propranolol, and finally after euthyroidism had been attained by carbimazole. during propranolol t3/t4 ratio decreased, whereas t4 remained unchanged. after carbimazole t3/t4 ratio returned to its pretreatment value. rt3/t4 ratio showed ... | 1977 | 576870 |
| ophthalmic graves's disease: natural history and detailed thyroid function studies. | of 27 patients with ophthalmic graves's disease (ogd) who had been clinically euthyroid three years previously, one became clinically hyperthyroid and seven overtly hypothyroid. improvement in eye signs was associated with a return to normal of thyroidal suppression by triiodothyronine (t3) and of the response of thyroid-stimulating hormone (tsh) to thyrotrophin-releasing hormone (trh). of a further 30 patients with ogd who had not been studied previously, three were overtly hypothyroid. of the ... | 1977 | 576414 |
| a microgel electrophoretic analysis the colloid in single rat thyroid follicles during thyroxine suppression. | a sequential study of the effect of thyroxine (t4) on the protein composition of the colloid in the rat thyroid gland has been carried out in 24 rats. daily ip injections of 20 mug thyroxine were given and the colloid was analyzed after 1, 2, 3 and 4 days and 1, 2 and 3 weeks. the protein constituents were separated by microgel electrophoresis and measured by microdensitometry. the incorporation of [3h]leucine into the thyroglobulin fraction and into the albumin-like protein in the homogenate of ... | 1977 | 576346 |
| effect of increased iodide intake on thyroid function in subjects on chronic lithium therapy. | thyroid function tests were obtained in 10 patients on chronic lithium therapy before and after the administration of potassium iodide 250 mg q.i.d. mean serum tsh rose by 8.9 muu/ml and mean serum t3 rose from 70 to 101 ng/dl. two patients became hypothyroid; a third showed a rise in tsh without any change in t3 or t4. a fourth patient developed hyperthyroidism probably secondary to the jod-basedow phenomenon. pharmacologic doses of iodine should be administered with caution to patients on chro ... | 1977 | 576345 |
| secretion of thyroxine, 3,5,3'-triiodothyronine and 3,3'5'-triiodothyronine in euthyroid man. | the secretion of iodothyronines from the normal human thyroid gland was assessed by radioimmunoassay analyses of the concentrations of thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (reverse t3, rt3) in thyroid venous and peripheral venous blood. the subjects studied were euthyroid patients undergoing parathyroid surgery. measurements were carried out both under apparently normal conditions, following peroral t3 pre-treatment, and before and after acute administration ... | 1977 | 576344 |
| transient recurrence of hyperthyroidism after delivery in graves' disease. | four patients with graves' disease whose hyperthyroidism was in remission following antithyroid therapy were studied without any treatment during and after pregnancy. in the 8-9th month of pregnancy, they were in a euthyroid state with serum levels of thyroxine (t4) of 18.9, 11.9, 11.2 and 14.5 mug/100 ml, triiodothyronine (t3) of 273, 190, 162 and 244 ng/100 ml and t3 resin sponge uptake (rt3u) of 22, 14, 19 and 16% respectively (normal pregnant range: t4, 7.0-15.0, t3 140-250, rt3u 15-25). at ... | 1977 | 576228 |
| evaluation of sodium l-thyroxine (t4) requirement in replacement therapy of hypothyroidism. | sodium-l-thyroxine (t4) was utilized in the treatment of 15 pediatric patients with hypothyroidism. adequacy of replacement therapy was confirmed by clinical evaluation in conjunction with determination of serum thyroxine, tri-odothyronine, and thyrotropin concentrations. daily dose of thyroxine capable of including clinical and biochemical euthyroidism ranged from 2.5 to 5 mug/kg of body weight with a mean of 3.5 +/- 0.3 mug in the 4- to 17-year-old age group. two infants with congenital hypoth ... | 1977 | 576137 |
| effect of a single dose of glucocorticoid on the diurnal variations of tsh, thyroxine, 3,5,3'-triiodothyronine, 3,3'5'-triiodothyronine and cortisol in normal men. | plasma thyrotropin (tsh) and cortisol concentrations were suppressed immediately after an intravenous bolus dose of 8 mg betamethasone in 6 male subjects. the circadian variations of these hormones disappeared for 40 hr (tsh) and 44 hr (cortisol). plasma thyroxine (t4), 3, 5, 3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3) levels did not show diurnal variations before betamethasone administration. plasma t3 levels decreased to 66% of the basal levels 20 hr after batamethasone adm ... | 1979 | 575506 |
| effect of chronic metoclopramide therapy on serum pituitary hormone concentrations. | the effect of chronic (3--9 months) therapy with metoclopramide on serum levels of pituitary and thyroid hormones was studied in 4 males and 1 female. the mean serum prolactin concentration during metoclopramide therapy was significantly higher than after discontinuation of metoclopramide. serum prolactin concentrations increased acutely after each dose of metoclopramide. serum prolactin concentrations increased acutely after each dose of metoclopramide, and gradually returned to normal by 6--12 ... | 1979 | 574121 |
| plasma thyroid hormone and glucocorticosteroid concentrations in the male rat following prolonged exposure to stress. | exposure of male csf rats to a signalled unpredictable 60-day stress regimen induced a significant elevation in circulating triiodothyronine (t3) concentration above the control for the first 20 days of stress before the rate of secretion returned to normal. on the other hand, circulating thyroxine (t4) concentration fell significantly below the control value for the first 5 days of stress before the normal rate of secretion was reached in 10 days. a histological study of the thyroid gland revea ... | 1979 | 573997 |
| diurnal rhythm of pituitary-thyroid axis in male rats and the effect of adrenalectomy. | levels of tsh, thyroxine (t4) and triiodothyronine (t3) were measured by radioimmunoassay in plasma (tsh, t4, t3) and pituitary (tsh) of 60-day old male long-evans rats. definite diurnal rhythms were demonstrated in pituitary tsh, plasma tsh and t3 in intact rats, evidenced by the statistically significant differences between zenith and nadir for pituitary tsh, plasma tsh and t3. the zenith value of pituitary tsh and the nadir values of plasma tsh, t4 and t3 were observed at the same time (2400 ... | 1979 | 573683 |
| prolactin, lh, tsh, t3 and t4 in patients with urogenital carcinomas. | serum level of peptide hormones lh, fsh, tsh and prolactin have been measured in patients with urogenital tumor. in this randomized study we found a frequent elevation of tsh and prolactin, which did not correlate. increased serum level of tsh was confirmed to be without any elevation of serum t3 and t4. in some of these patients ectopic production of peptides may account for this abnormality. systemic change of peptides in elderly patients, however, must be taken into consideration as well. | 1979 | 573007 |
| sinemet and thyroid function in parkinson disease. | patients on chronic carbidopa-levodopa (sinemet) therapy underwent thyroid function testing that included measurement of serum thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), t3 uptake (t3u), free t4 index (ft4i), and free t3 index (ft3i). the subjects were studied both in a random sampling and in a controlled manner, fasting and 2 hours after receiving the drug. all subjects were euthyroid by testing, and there was no significant difference in thyroid hormone levels of patients and co ... | 1979 | 572939 |
| influence of ethanol on thyroxine accumulation in the hypothalamus, pituitary gland and cerebrospinal fluid in the newborn rabbit. | the effect of ethanol on thyroxine (t4) accumulation in the hypothalamus (h), pituitary gland (p) and cerebrospinal fluid (csf) has been investigated in 1-15-day-old rabbits. it has been found that h or csf serum ratios decreased with age by about 2 in the course of 13 postnatal days. stable t4 resulted in an increase of 125 i-t4 in h, p and csf. ethanol per se caused an increase in transfer and accumulation of radiothyroxine or made the changes after loading animals with carrier t4 more pronoun ... | 1979 | 571351 |
| effect of vasectomy on thyroid function. | long-evans rats vasectomized unilaterally or bilaterally at 2 months of age showed marked reductions in weight of testes, seminal vesicles and prostate glands 2 and 12 months post-vasectomy. thyroid weight, thyroid 131i uptake, serum pb131i, circulating levels of serum t4 and chromatographic analysis of thyroid hydrolysates revealed no alterations due to vasectomy. these findings indicate that vasectomy, unilateral or bilateral, and whether of 2 or 12 months duration, did not exert an effect on ... | 1978 | 569891 |
| [sex hormone binding globulin (shbg), a new metabolic in vitro thyroid function test]. | shbg (sex hormone binding globulin) is a carrier protein for the sex hormones testosterone and estradiol with a molecular weight of about 95000 dalton. it can be used as a metabolic test of thyroid function. shbg was measured by the adsorption method of mickelson and petra; the shbg contained in serum is incubated with 3h-5alpha-dihydrotestosterone and adsorbed to a cellulose filter. thirty-eight female patients with hyperthyroidism before treatment had markedly elevated levels of shbg (x +/- sd ... | 1978 | 568820 |
| serum t4 and t3 in active and torpid ground squirrels, spermophilus richardsoni. | 1978 | 566236 | |
| [serum t4 determination with a double-antibody technic--studies of thyroxine(t4) "eiken kit"]. | 1978 | 564763 | |
| in vivo functional interaction between dna polymerase and dcmp-hydroxymethylase of bacteriophage t4. | some mutations in the structural gene for t4 dna polymerase (gene 43) behave as suppressors of a deficiency in t4 dcmp-hydroxymethylase (gene 42). the suppression appears to involve a functional interaction between the two enzymes at the level of dna replication. the hydroxymethylase deficiency caused dna structural abnormalities in replication, and dna polymerase lesions appeared to partially reverse these abnormalities. the results do not necessarily imply protein-protein interactions between ... | 1977 | 562423 |
| hypoliquorreic headache and pneumocephalus caused by thoraco-subarachnoid fistula. | one month after having a right upper lobectomy to remove a squamous cell carcinoma, a 43-year-old man presented with a 4-day history of postural headache, worsened by standing and relieved by lying. skull films showed prominent ventricular pneumocephalus. iophendylate myelography was unrewarding, but isotope cisternography revealed a csf fistula at the t4 level, extending into the thoracic cavity. thoracoplastic removal of the first four ribs successfully prevented air passage and the patient ha ... | 1977 | 561915 |
| [tri-iodine-thyronin (t3)-hyperthyreosis (author's transl)]. | report on a girl aged 12 years and 2 months and a boy aged almost 14. the first always had normal t4- with always raised t3, belongs, therefore, to the entity t3-hyperthyreosis described by hollander in 1968. the boy had clear clinical signs of hyperthyreosis, but was untreated for 14 months, because a nuclear medical institute had found t4 to be normal and did not investigate t3. one suspects that proper treatment would have been given, if t3 would have been examined early. discussion of the en ... | 1977 | 561268 |
| [experimental and clinical studies on thyroxine determination with a new thyroxine radioimmunoassay kit, t4 ria pack]. | 1977 | 560265 | |
| [experimental and clinical studies of ria-mat t4 kit]. | 1977 | 559840 | |
| [determination of the serum thyroxine level with riamat t4 kit]. | 1977 | 559566 | |
| the effect of triiodothyronine on 2-deoxy-d-(1-3h)glucose uptake in cultured chick embryo heart cells. | the uptake of 2-deoxy-d-[1-3h]glucose ([1-3h]dog)by cultured chick embryo heart cells was stimulated by exposure to triiodothyronine (t3). the concentration of free t3 for half maximal stimulation of [1-3h]dog uptake was 8.7 x 10(-10)m. nuclear binding studies revealed that the kd for t3 was 4.2 x 10(-10)m. the molar potencies of other thyroactive compounds in stimulating [1-3h]dog uptake, relative to l-t3, were: 500% for 3'-isopropyl-3,5-diiodo-l-thyronine, 20% for l-thyroxine (t4), 17% for d-t ... | 1977 | 558872 |
| [studies of rcc (radiochemical center) t4 radioimmunoassay kit (t4 ria pack)]. | 1977 | 558846 | |
| [experimental and clinical studies of ria-mat t4 kit]. | 1977 | 558840 | |
| [measurement of serum t4 by competitive protein binding analysis: tetrasorb e kit]. | 1977 | 558073 | |
| [measurement of blood thyroxine (t4) levels by ria-mat t4]. | 1977 | 558069 | |
| [clinical and experimental studies of serum thyroxine concentration by t4-ria pac]. | 1977 | 557665 | |
| comparison of the biological effects of thyroxine and triiodothyronine in the rat. | to compare the biological effects of thyroxine (t4) and triiodothyronine (t3), the results of varying the production rates of t3 and t4 independently were evaluated. in one set of experiments, the responses of hypothyroid rats to thyroid hormones were measured in terms of weight gain, hepatic mitochondrial alpha-glycerophosphate dehydrogenase (alphagpd) and serum tsh. t4 was given with, and without, 6-n-propylthiouracil (ptu) and alphagpd activity paralleled, and could completely be accounted fo ... | 1977 | 556986 |
| ["low triiodothyronine (t3) syndrome": "thyroxine (t4) euthyroidism" evidence (author's transl)]. | as first described in serious systemic illnesses isolated decreased t3 plasma concentration was related to impaired peripheral conversion of t4, to t3 with preferential production of reverse t3 (rt3). a "low t3 syndrome" was seen in 47 out of 109 patients with extra-thyroidal diseases. metabolic state, tsh and tsh responses to trh were normal despite of low t3 concentration. euthyroidism seems mainly due to t4 itself in these patients. | 1979 | 554102 |
| [metabolism of thyroxine in acute viral hepatitis]. | aim of this report was to define the correlation between hepatic acute damage and thyroxine metabolism. we have studied plasma levels of t4, t3, rt3 and tsh in 18 adult male subjects with acute viral hepatitis. no significant variation of t4, t3 and tsh plasma levels was found in different phases of disease. however, plasma rt3 levels were clearly elevated in 72% of patients in the first 7 days (mean 440 pg/ml vs 198 pg/ml of normal controls) and in 17% of cases in the second 10 days of disease ... | 1979 | 553591 |
| [thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient nath diet]. | the administration of drinking-water, added with licl (20mg li+/l) to rats fed on "atherogenic" diet without cholesterol (casein 20% hydrogenated coconut oil 25%, sucrose 49.1%) for 90 days, elicits an expressive diminution of haematic lipids (triglycerides, free fatty acids, total cholesterol) and hepatic cholesterol. the serum dosages of thyroid hormones t3 and t4 show that the li+ concentration used in the experiment do not inhibit the glandular functions. | 1979 | 553577 |
| [correlation between red cell 2,3-dpg and serum levels of thyroid hormones in newborn infants]. | the correlation between red cell 2,3-dpg and serum levels of thyroid hormones (t4 and t3) has been evaluated in full-term newborns, 1 to 4 days old. a direct effect of thyroxine (t4) on the post-natal increase of red cell 2,3-dpg was excluded because no significant correlation was found between the rise of 2,3-dpg concentration and serum t4 level. | 1979 | 553555 |
| [effect of surgical stress on tsh and on the extra-thyroid metabolism of t4 (preliminary experiment)]. | the effect of the surgery on the tsh and on the extra thyroid t4 metabolism was studied in thirty euthyroid patients. the tsh showed a light increase thirty minutes after the skin cut. there were no remarkable changes of t4 serum levels, while the serum triiodothyronine concentration fell during and after the operation, with a concomitant rise in reverse triiodothyronine. | 1979 | 552848 |
| the effect of perinatal factors on cord thyroxine concentration. | cord blood thyroxine (t4) concentrations were measured in 4,068 infants from 28 wk gestation to term. each chart was reviewed for the following factors: delivery by cesarean section, prolonged rupture of membranes, neonatal asphyxia, meconium-stained amniotic fluid, maternal diabetes mellitus and twinning. each neonate was evaluated for the idiopathic respiratory distress syndrome, and low (sga) or high (lga) birthweight for gestational age. within each gestational age group, the mean cord t4 va ... | 1978 | 551930 |
| antarctic wintering--over, suggestion and transient olfactory stimulation: eeg evoked potential and electrodermal responses. | eeg evoked potential and electrodermal responses to real and suggested olfactory stimulation were recorded on a team of nine men who wintered-over at scott base, antarctica. multi-variate analysis of variance findings indicated some consistent trends despite adverse conditions and marked inter-individual differences. consistent with studies of secondary afferentation olfaction-related eegs were evidenced in the occipital area (o1 and o2) as well as the temporal area (t3 and t4). skin conductance ... | 1979 | 548128 |
| synthesis of oligonucleotides with t4 rna ligase. | 1979 | 547234 | |
| [relative variation of t3, t4 and tsh plasma levels in patients with primary hypothyroidism]. | 1979 | 545481 | |
| [variations in thyroid hormone levels concomitant with age in a normal population. ii: levels of t4 in plasma]. | 1979 | 545468 | |
| destruction of bacterial viruses in serum by heat and radiation under conditions that sustain the ability of serum to support growth of cells in suspended culture. | methods for inactivating bacterial viruses in serum were developed through the use of heat and ionizing radiation, and the effects of these treatments on the growth rates of cultured cells were tested. viruses chosen for this study were the radiation-resistant bacteriphage f2 and heat-resistant phage t4. the viabilities of these phages were reduced more than 2 and 4 orders of magnitude, respectively, by a treatment at 60 degrees c for 30 min followed by 420 krads of ionizing radiation. simultane ... | 1979 | 544633 |
| [iodoamino acid distribution and weight of the thyroid gland, t4 serum level and t4 metabolism in relation to diet, body fat content and age of rats]. | rats were rendered obese by feeding them a fatty diet (hfd, fat: 50% of weight). at the end of the experimental period the animals were divided, also the control rats, which were fed a low-fat diet (lfd, fat: 3% of weight), in light and heavy weight groups. the heavy and obese hfd groups showed, unlike the light lfd-animals, equal absolute but significantly lower relative thyroidal weights. the absolute thyroidal weights of light and heavy animal groups, which received in each case the same diet ... | 1979 | 543366 |
| thyroid function in breast cancer patients before and up to two years after mastectomy. | in 41 women newly diagnosed as having breast cancer the thyroid function was assessed by determination of the serum tsh, tririodothyronine (t3), reverse triiodothyronine (rt3), thyroxine (t4), t3-resin uptake and free t4-index. blood samples were drawn before the primary treatment and at follow-up after 7-28 months. there was no significant change in any of these variables during the period of observation. nor was there any difference between the values of the patients who developed recurrent di ... | 1979 | 543051 |
| [effects of t3, t4 and methyltiouracile short-term treatments on plasma and liver lipid levels in rats (author's transl)]. | the effects of short-term administration of thyroid hormones (t3 and t4) and methyltiouracile (mtu) on liver and plasma lipid levels in female rats have been comparatively studied t3 increases the levels of all the studied liver lipids and decreases the plasma lipids. t4 produces smaller and even, in some cases (liver triglycerides and cholesterol esters), opposite effects. the administration of mtu produces, in general, opposite effects to t3 and t4. | 1979 | 542704 |
| [correlation between the plasma levels of t3, t4 and tsh in a normal population]. | 1979 | 542676 | |
| thyroid-hormone concentrations after radioiodine therapy for hyperthyroidism. | fourteen hyperthyroid patients (11 men, three women), ages 28-66, were followed with serial measurements of serum thyroid hormone levels for 1 mo after therapy with i-131. twelve patients had diffuse toxic goiters (25--70 g in size); two patients had multinodular glands (40--100 g). the patients were taking no antithyroid medications; ten patients were treated with propranolol. all patients received the equivalent of 5000 rad, except the two with multinodular glands, who received larger doses. t ... | 1979 | 541694 |
| regulation of imm gene expression in bacteriophage t4-infected cells. | two polypeptides (imm-a and imm-b) which are not induced by an immunity mutant t4dimm2 but by a wild-type strain t4d were identified by sodium dodecyl sulphate (sds)-polyacrylamide gel electrophoresis. their mol. wt. were 77 000 and 45 000, respectively. these polypeptides exhibited a similar kinetic pattern of synthesis. within a few minutes p.i. the primary phage established the system that inhibited imm gene expression of superinfecting phage. this was shown by measuring both the phenotypic e ... | 1979 | 541664 |
| changes in circulating l-thyroxine and l-triiodothyronine of the masu salmon, oncorhynchus masou accompaning the smoltification, measured by radioimmunoassay. | serum levels of l-thyroxine (t4) and l-triiodothyronine (t3) of the masu salmon, oncorhynchus masou, were measured by radioimmunoassay during the months from march to september. serum levels of t4 and t3 varied from 0.06 to 1.44 microgram and from 0.06 to 0.35 microgram per 100 ml serum respectively, although t4 content could not be detected in some specimens. t4 levels showed a seasonal fluctuation in which a higher value was observed in april when parr-smolt transformation was proceeding. t4 l ... | 1979 | 540573 |
| the pathogenesis of propranolol-withdrawal syndrome in essential hypertension. | 1. in hypertension, the beta-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis. 2. the effect of abrupt cessation of propranolol on serum concentrations of thyroxine (t4) and triiodothyronine (t3) was therefore investigated in five patients with uncomplicated essential hypertension, treated with propranolol in doses from 160 to 480 mg/day. 3. four of the five patients developed one or more of the above-menti ... | 1979 | 540462 |
| the effect of rapeseed meal and methimazole on levels of plasma hormones in growing broiler cockerels. | the effects of feeding a heat treated rapeseed meal, which has goitrogenic properties, on the concentrations of plasma pituitary and thyroid gland hormones was investigated in broiler cockerels of between 3 and 10 weeks of age. for purposes of comparison, two other groups were included in the study; one was fed the goitrogen, methimazole, and the other a normal control diet. the hormones measured were thyroxine (t4), triiodothyronine (t3), growth hormone (gh), prolactin, and luteinizing hormone ... | 1979 | 537986 |
| three suppressor forms of bacteriophage t4 leucine transfer rna. | 1979 | 537091 | |
| the effects of post-ganglionic axotomy on selective synaptic connexions in the superior cervical ganglion of the guinea-pig. | stimulation of preganglionic axons arising from different levels of the thoracic spinal cord causes different effects on end-organs supplied by the superior cervical ganglion (langley, 1892; nja & purves, 1977a; lichtman, purves & yip, 1979). for example, stimulation of the first thoracic ventral root (t1) causes pupillary dilatation and widening of the palpebral fissure; stimulation of t4, on the other hand, has little effect on the eye, even though axons arising from this level innervate about ... | 1979 | 536928 |
| radioimmunoassay of free thyroxine with prebound anti-t4 microcapsules. | free thyroxine (ft4) may be one of the active throid hormones in contact with target end organs. it is unaffected by alterations in serum protein levels. in most cases, measurement of ft4 reflects an individual's true thyroid function or dysfunction. previous ft4 assay techniques have been difficult, tedious, indirect, and inaccurate. a rapid, simple, and accurate radioimmunoassay for ft4 has been developed using microencapsulated rabbit anti-t4 antiserum to which i-125 t4 tracer of high specifi ... | 1979 | 536842 |
| a study of age-dependent changes in thyroid function tests in adults. | total serum thyroxine (t4), triiodothyronine (t3), t3 resin uptake (t3u), thyrotrophin (tsh), and reverse t3 (rt3) were measured in 209 healthy adults 20--89 yr old. mean t4 values for men were stable throughout life, but in females under age 60, t4 values were significantly higher than in older women. values for t3u in males were significantly higher than in females throughout all decades, although females had a significant increase in t3u after age 60. tsh values increased significantly in fem ... | 1979 | 536771 |
| low muscle and liver glycogen contents in dogs treated with thyroid hormones. | muscle biopsies for glycogen determinations were taken from dogs before (controls) and after prolonged treatment with thyroid hormones (t4 or t3). the glycogen content in quadriceps femoris was measured before exercise, immediately after its cessation, and during 24h of post-exercise recovery. the effect of thyroxine treatment on the liver glycogen content both at rest and following physical effort was also studied. a marked decrease in the muscle glycogen content determined at rest was found bo ... | 1979 | 535882 |
| blood serum triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh) concentrations in healthy children at the age of 1 and 2 years. | the physiological mean concentrations of t3, t4 an tsh in 150 healthy children aged from 1 month to 2 years of life decreased gradually with age. the statistically significant difference was observed only in t3 levels between the first and second year of life. the remaining parameters did not show statistically significant differences. | 1979 | 535584 |
| [t4 metabolism in age matched heavy and light rats with good and bad feed efficiency following high- or low-in-fat diet]. | rats, fed two diets (high or low in fat content), were at the and of the feeding-period separated in light and in heavy animal groups. the leaner rats from the diet group high in fat content show opposite to the heavier animals of this diet group significantly increased t4 distribution spaces, significantly shortened t4 half life time and lower feed efficiency. t4 serum values, absolute t4 degradation per day and body mass and free thyroxine index in these leaner rats also increased significantl ... | 1979 | 535577 |
| [thyroidal radioiodine uptake and t4 metabolism in nutritionally obese rats]. | 1979 | 535576 | |
| effects of age on the metabolism of thyroid hormones by rat brain tissue in vitro. | using a newly-devised chromatographic method for the separation of the acetic and propionic analogues of triiodothyronine (t3) and thyroxine (t4), we studied the metabolism of radioactively labeled t3 and t4 in rat brain homogenates to determine whether the rates of metabolism and the types of products formed are influenced by the age of the animal. the separation of metabolites is achieved on silica gel h in a solvent system consisting of methylacetate-2.5% ammonia (w/v) (95:5 v/v). results cle ... | 1979 | 535533 |
| hormonal factors in osteoporosis. | primary osteoporosis is a ubiquitous disease of unknown etiology. the condition undoubtedly has multiple causes and the metabolic pattern of bone loss may vary significantly from case to case. five hormones, pth, gonadal steroids, ct, t3 and t4, and glucocorticoids, and possibly a sixth, gh, have fundamental actions on bone metabolism and may therefore be causally involved in primary osteoporosis. a consideration of selected data on hormonal interactions culled from a much larger body of experim ... | 1979 | 535238 |
| [treatment of ureteral obstructions due to prostatic carcinoma. prognostic value of response to medical treatment (author's transl)]. | a retrospective study concerning 146 patients with prostatic cancer showed that 30 of them (20 p.cent) presented ureteral obstacles at some time during the evolution of the disease. the majority of these cases were t3-t4 tumors. when a strickly medical approach allowed to reduce the obstruction, the 1 year survived rate was 71 p.cent. when surgery became necessary due to persistent renal insufficiency, in spite of medical treatment the 1 year survival rate was 15 p.cent. | 1979 | 534164 |
| [studies on the measurement of serum thyroxine with "spac t4 ria kit" (author's transl)]. | 1979 | 533936 | |
| reassembly of the bacteriophage t4 tail from the core-baseplate and the monomeric sheath protein p18: a co-operative association process. | 1979 | 533896 | |
| thyroid hormones and adipose tissue development. | the effect of thyroid hormones on the cellularity of the retroperitoneal adipose tissue (r.p.a.t.) was investigated in rats that were 3, 6 and 12 weeks old. two groups of rats were respectively made hypothyroid by the antithyroid compound propylthiouracil, or hyperthyroid by thyroxine. the number of adipocytes was less in the hypothyroid rats than in the controls; it was higher in the hyperthyroid rats without any concomitant increase in the weight of their r.p.a.t. moreover, there was no signif ... | 1979 | 533870 |
| cavernosography in the management of prostatic cancer. | cavernosograms were used in the investigation of 22 patients with prostatic cancer to determine the incidence of venous invasion. there were 21 patients with t3/t4 category tumours and one with a t2 tumour. all but one, a t3 tumour, had the radiological features of periprostatic venous malignant thrombosis. an attempt was made to correlate these findings with lymphography and tumour grade but no correlations could be made and the clinical relevance of these findings remains uncertain. | 1979 | 533598 |
| evaluation of plasma hormone concentrations in relation to clinical staging in patients with prostatic cancer. british prostate study group. | plasma concentrations of testosterone, oestradiol-17 beta, luteinising hormone (lh), follicle stimulating hormone (fsh), prolactin and growth hormone (gh) were measured in patients with histologically proven prostatic cancer, before any form of therapy was given for this disease. patients were categorised according to uicc classification. no systemic change in the group means of any of these hormones was associated with the progression of the disease from the t0 to the t4 stage. when multivariat ... | 1979 | 533596 |
| transient infantile hyperthyrotropinaemia. report of a case. | a case of transient hyperthyrotropinaemia was found by mass screening for neonatal hypothyroidism using the paired tsh assay method. the patient was a baby boy born at term after a normal pregnancy who grew without any abnormal signs or symptoms. for the first 7 months after birth, his serum tsh was abnormally high while his total serum t4, t3, and free t4, t3 were within normal limits, exept for slightly low free t4 level at 7 months. the raised serum tsh decreased spontaneously to within norma ... | 1979 | 533303 |