Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| epigenetic changes in neurology: dna methylation in multiple sclerosis. | epigenetics is defined as the study of the mechanisms that regulate gene expression without altering the underlying dna sequence. the best known is dna methylation. multiple sclerosis (ms) is a disease with no entirely known etiology, in which it is stated that the involvement of environmental factors on people with a genetic predisposition, may be key to the development of the disease. it is at this intersection between genetic predisposition and environmental factors where dna methylation may ... | 2015 | 25976949 |
| [antiviral properties of basidiomycetes metabolites]. | the data on the antiviral action of the ganoderma lucidum, lentinus edodes, grifola frondosa, agaricus brasiliensis and other basidiomycetes metabolites are summurized. the metabolites of these species of basidiomycetes exhibit a direct antiviral effect on herpes simplex virus types i and ii, human immunodeficiency virus (hiv), hepatitis b virus, vesicular stomatitis virus, influenza virus, epstein-barr virus, and others. moreover, metabolites of basidiomycetes increased antiviral immunity. | 2014 | 25975107 |
| ebv+ diffuse large b-cell lymphoma arising within atrial myxoma in chinese immunocompetent patient. | the incidence rate of primary cardiac lymphoma is very low. primary cardiac lymphoma within myxoma is extremely rare disease. so far, these cases have been reported only eight in the world, which has not reported in chinese so far. hence, we reported the unique chinese case of 52-year-old immunocompetent male with primary epstein-barr virus positive diffuse large b-cell lymphoma arising within atrial myxoma, and had no evidence of systemic lymphoma. the patient presented right sided body numbnes ... | 2015 | 25973119 |
| epstein-barr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature. | a 61-year-old woman was diagnosed as having rheumatoid arthritis (ra) and began treatment with salazosulfapyridine (sasp) and methotrexate (mtx) in 2008; the administration of concomitant tacrolimus (tac) was initiated in 2010. she subsequently developed concurrent multiple myeloma (mm), immunoglobulin g (igg)-κ type, in 2012. a portion of the tumor cells tested positive for epstein-barr virus-encoded small rna (eber). mtx treatment was discontinued in 2014, and the exacerbation of mm ensued. th ... | 2015 | 25973110 |
| aberrant epstein-barr virus antibody patterns and chronic lymphocytic leukemia in a spanish multicentric case-control study. | epstein-barr virus (ebv)-related malignancies harbour distinct serological responses to ebv antigens. we hypothesized that ebv serological patterns can be useful to identify different stages of chronic lymphocytic leukemia. | 2015 | 25972916 |
| regulation of dna damage signaling and cell death responses by epstein-barr virus latent membrane protein 1 (lmp1) and lmp2a in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is closely associated with latent epstein-barr virus (ebv) infection. although ebv infection of preneoplastic epithelial cells is not immortalizing, ebv can modulate oncogenic and cell death mechanisms. the viral latent membrane proteins 1 (lmp1) and lmp2a are consistently expressed in npc and can cooperate in bitransgenic mice expressed from the keratin-14 promoter to enhance carcinoma development in an epithelial chemical carcinogenesis model. in this study, lmp1 ... | 2015 | 25972552 |
| an unusual presentation of cardiac tamponade associated with epstein-barr virus infection. | we present a case of an 80-year-old woman who presented with a dry cough, shortness of breath and general malaise. she had presented 5 days previously with a sore throat, feeling feverish and with non-specific symptoms. her background included paroxysmal atrial fibrillation and hypertension. she was initially thought to have decompensated heart failure secondary to atrial fibrillation and was initiated on diuretic therapy. however, a transthoracic echocardiogram performed revealed collapse of th ... | 2015 | 25972381 |
| long-term survival of patient with epstein-barr virus-positive gastric cancer treated with chemotherapy: case report. | 2016 | 25972063 | |
| loss of b-cell receptor expression defines a subset of diffuse large b-cell lymphoma characterized by silent bcr/pi3k/akt signaling and a germinal center phenotype displaying low-risk clinicopathologic features. | b-cell receptor (bcr) signaling is crucial for the survival of normal and neoplastic b cells, and inhibitors targeting bcr signaling pathways have shown promising therapeutic outcomes for patients with b-cell lymphomas. in the current study, we analyzed de novo diffuse large b-cell lymphoma without bcr expression (dlbcl, bcr) in 25 cases to determine the bcr/phosphatidylinositol-3-kinase/akt (bcr/pi3k/akt) signaling status, clinicopathologic features, and underlying causes leading to the loss of ... | 2015 | 25970684 |
| epstein-barr virus-positive pyothorax-associated lymphoma arising from a posttraumatic empyema. | pyothorax-associated lymphoma (pal) develops from a pyothorax caused by an artificial pneumothorax created during the treatment of pulmonary tuberculosis or tuberculous pleuritis. we report the first case of epstein-barr virus (ebv)-positive pal arising from a posttraumatic empyema. a 75-year-old woman with chronic posttraumatic empyema presented with a tumor, which was connected to the wall of a pyothorax in the right thoracic cavity. she had a history of trauma to the right chest, which had oc ... | 2015 | 25968626 |
| update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies. | tobacco use and alcohol consumption are the main risk factors associated with head and neck squamous cell carcinoma (scc) development due to their cytotoxic and mutagenic effects on the exposed epithelia of the upper aerodigestive tract. epstein-barr virus (ebv) and high-risk human papillomaviruses (hpvs), both encoding viral oncoproteins able to interfere with cell cycle control, have been recognized as the etiological agents of nasopharynx carcinoma and a fraction of oropharyngeal carcinoma, r ... | 2015 | 25967534 |
| the serum cxcl13 level is associated with the glasgow prognostic score in extranodal nk/t-cell lymphoma patients. | the glasgow prognostic score (gps) measures inflammation and proves its prognostic value in patients with extranodal natural killer (nk)/t-cell lymphoma (enktl) which is commonly combined with inflammatory lesion. given inflammatory chemokines play an important role in tumor progression, we hypothesized that chemokines might influence enktl aggressiveness through interaction with their receptors in the tumor tissue. | 2015 | 25966773 |
| novel association of killer cell immunoglobulin-like receptor genes with ebv-infectious diseases in children. | killer cell immunoglobulin-like receptors (kirs) which are mainly expressed on natural killer (nk) cells are implicated in many virus infections. however, it is unclear whether or not kirs are associated with susceptibility to epstein-barr virus (ebv) infection related diseases. therefore, the purpose of our study was to investigate possible correlation between polymorphisms of kir genes and infectious mononucleosis (im)/ebv-associated hemophagocytic lymphohistiocytosis (ebv-hlh). the polymorphi ... | 2015 | 25966757 |
| roles of epstein-barr virus bglf3.5 gene and two upstream open reading frames in lytic viral replication in hek293 cells. | the epstein-barr virus (ebv) predominantly establishes a latent infection in b lymphocytes, but a small percentage of infected cells switch from the latent state to the lytic cycle, leading to potent viral dna replication and progeny viruses production. we here focused on a lytic gene bglf3.5, and first established bglf3.5 mutants by marker cassette insertion. unexpectedly, this insertion mutant failed to produce bglf4 protein and thus progeny production was severely inhibited. then we carefully ... | 2015 | 25965794 |
| a patient with elderly-onset atypical hydroa vacciniforme with an indolent clinical course. | hydroa vacciniforme (hv) is a rare photodermatosis that mainly affects children and manifests as vesiculopapular eruptions in sun-exposed areas without systemic symptoms. hv-like lymphoma (hvll) is one of the epstein-barr virus (ebv)-associated lymphoproliferative disorders (lpd) of childhood. its diagnosis is based on monoclonal t-cell proliferation; however, its degree of malignancy is controversial owing to its variable prognosis. elderly-onset cases of these diseases are extremely rare, and ... | 2015 | 25965563 |
| does belatacept improve outcomes for kidney transplant recipients? a systematic review. | belatacept was intended to provide better outcomes for kidney transplant (kt) recipients by allowing minimization/withdrawal of calcineurin inhibitors (cni) and steroids. | 2015 | 25965549 |
| erratum: nasopharyngeal carcinoma in brunei darussalam: low incidence among the chinese and an evaluation of antibodies to epstein-barr virus antigens as biomarkers. | [this corrects the article on p. 371 in vol. 50, pmid: 19421680.]. | 2014 | 25964953 |
| reversible methotrexate-associated lymphoma of the liver in rheumatoid arthritis: a unique case of primary hepatic lymphoma. | primary hepatic lymphoma (phl) is an extremely rare disease, frequently associated with viruses such as hepatitis b virus (hbv), hepatitis c virus (hcv), and human immune deficiency virus (hiv). on the other hand, an increased risk of lymphoproliferative disorders (lpd) has been demonstrated in patients treated with immunosuppressive drugs such as methotrexate (mtx) for rheumatoid arthritis (ra). the role of epstein-barr virus (ebv) has been discussed in the pathogenesis of the immunodeficiency- ... | 2015 | 25964853 |
| combining cal-101 with celecoxib enhances apoptosis of ebv-transformed b-cells through mapk-induced er stress. | phosphoinositide-3 kinase (pi3k) inhibition attenuates proliferation and survival in b-cell malignancies. celecoxib induces endoplasmic reticulum (er) stress-induced apoptosis via a cyclo-oxgenase-2 (cox2)-independent manner in certain types of cancer cells. in the present study, we assessed the effects of combinations of drugs with a p110δ-specific inhibitor, cal-101, and celecoxib to induce apoptosis in epstein-barr virus (ebv)-transformed b-cells and non-hodgkin's lymphoma (nhl) cells. | 2015 | 25964548 |
| establishment of patient-derived cancer xenografts in immunodeficient nog mice. | viable and stable human cancer cell lines and animal models combined with adequate clinical information are essential for future advances in cancer research and patient care. conventional in vitro cancer cell lines are commonly available; however, they lack detailed information on the patient from which they originate, including disease phenotype and drug sensitivity. patient-derived xenografts (pdx) with clinical information (so-called 'cancer xenopatients') are a promising advance that may acc ... | 2015 | 25963555 |
| molecular mimicry of mage-a6 and mycoplasma penetrans hf-2 epitopes in the induction of antitumor cd8(+) t-cell responses. | a promising vaccine strategy for the treatment of cancer involves the use of vaccines incorporating tumor antigen-derived synthetic peptides that can be coordinately recognized by specific cd4(+) and cd8(+) t-cells. previously, we reported that a mage-a6-derived peptide (mage-a6172-187) and its highly-immunogenic and cross-reactive homolog derived from mycoplasma penetrans hf-2 permease (hf-2216-229) are promiscuously presented by multiple hla-dr alleles to responder cd4(+) t-cells obtained from ... | 2017 | 25960935 |
| acute acalculous cholecystitis in a 17-year-old girl with epstein-barr virus infection. | acute cholecystitis is most frequently concomitant with cholelithiasis, whereas acute acalculous cholecystitis is usually of an infectious aetiology. among the aetiological factors, epstein-barr virus (ebv) infection is also mentioned. the case of a 17-year-old girl is described, hospitalised in the children's clinical hospital, paediatric clinic, at the medical university in lublin, due to fever, upper abdomen pain lasting for a week, and nausea for several days. based on the diagnostic - labor ... | 2015 | 25960817 |
| severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal crohn's disease. | we present a 22-year-old male who developed a severe erosive oesophagitis extending to the pharynx and oral cavity without obvious risk factors. endoscopic image suggested viral aetiology that could not be confirmed by routine serological diagnostics of infections with cytomegalovirus, epstein-barr virus, and herpes simplex virus. the histopathological evaluation also gave no definite clues to the aetiology of the inflammation. treatment with acyclovir was ineffective, but gancyclovir therapy ca ... | 2015 | 25960815 |
| sequence analysis of ebv immune evasion gene bnlf2a in ebv associated tumors and healthy individuals from nasopharyngeal carcinoma endemic and non-endemic regions of china. | bnlf2a is an epstein-barr virus (ebv) immune evasion gene. its protein is located in the endoplasmic reticulum (er) membrane, and can inhibit the antigen transporting function of tap, thereby perturbing the immune response to ebv in lytic and prelatent phase. in order to explore whether the polymorphism of bnlf2a gene has a role in different types of ebv associated tumors, we conducted complete sequencing of the gene bnlf2a in 408 cases of ebv positive tumors (76 lymphomas, 45 gastric carcinomas ... | 2015 | 25959517 |
| a heart breaking case of rapidly developing severe hemophagocytic syndrome secondary to chronic active ebv infection; a case report and review of the literature. | epstein-barr virus (ebv, hhv-4) is a gamma herpesvirus with a 90% >seroprevalence in adults. reactivations in non-immuno compromised individuals usually cause mild or no symptoms at all. rarely, host immunity-virus balance is interrupted, resulting in a chronic active ebv infection. the following case illustrates the rapid development of severe hemophagocytic syndrome during chronic active ebv infection in a 73 year old woman who presented with lower extremity pain and edema, splenomegaly and ab ... | 2015 | 25959150 |
| mitogen- and stress-activated kinase 1 mediates epstein-barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of fra-1 and c-jun genes. | mitogen- and stress-activated kinase 1 (msk1) is a nuclear kinase that serves as active link between extracellular signals and the primary response of gene expression. however, the involvement of msk1 in malignant transformation and cancer development is not well understood. in this study, we aimed to explore the role of msk1 in epstein-barr virus (ebv) latent membrane protein 1 (lmp1)-promoted carcinogenesis of nasopharyngeal carcinoma (npc). | 2015 | 25958199 |
| using proximity biotinylation to detect herpesvirus entry glycoprotein interactions: limitations for integral membrane glycoproteins. | herpesvirus entry into cells requires coordinated interactions among several viral transmembrane glycoproteins. viral glycoproteins bind to receptors and interact with other glycoproteins to trigger virus-cell membrane fusion. details of these glycoprotein interactions are not well understood because they are likely transient and/or low affinity. proximity biotinylation is a promising protein-protein interaction assay that can capture transient interactions in live cells. one protein is linked t ... | 2015 | 25958131 |
| epstein-barr virus-positive primary cutaneous follicle centre lymphoma; an age-related phenomenon? | primary cutaneous follicle centre lymphoma is the most frequently encountered primary cutaneous b cell lymphoma, often presenting in the head and neck region. treatment is locally directed with surgery and/or radiotherapy. the prognosis is usually excellent with only local recurrences and generally no dissemination to extracutaneous sites. epstein-barr virus (ebv) is frequently encountered in lymphoproliferative disorders associated with immunosuppression, typically iatrogenic and congenital, or ... | 2015 | 25957860 |
| 6-year-old boy with recurrent sinopulmonary infections and lymphadenopathy. | 2015 | 25956317 | |
| the role of epstein-barr virus-encoded microrna bart7 status of resection margins in the prediction of local recurrence after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma. | local recurrence is the major cause of treatment failure in patients who undergo surgical salvage of recurrent nasopharyngeal carcinoma (npc) after radiotherapy. the authors investigated the role of epstein-barr virus (ebv)-encoded bam hi-a rightward transcript 7 microrna (bart7) status in resection margins in the identification of a subgroup of patients who may benefit from adjuvant reradiation after surgery. | 2015 | 25955785 |
| primary central nervous system posttransplantation lymphoproliferative disorder after heart and lung transplantation. | primary central nervous system posttransplantation lymphoproliferative disorder (pcns-ptld) is uncommon, especially after heart or lung transplantation. database analysis from a single heart and lung transplantation centre and a literature review pertaining to pcns-ptld was performed. in this study, the prevalence of pcns-ptld was 0.18% after heart and/or lung transplants. of 1674 transplants, three cases of pcns-ptld developed 14 months, 9 years and 17 years posttransplant, and all were epstein ... | 2015 | 25955465 |
| using recombinant chlamydia trachomatis omp2 as antigen in diagnostic elisa test. | the obligate intracellular bacterium chlamydia trachomatis causes sexually transmissible diseases in human. timely and sensitive detection of this pathogen is very important. there are many cross-reactions in bacteriological and serological methods in detection of this type of pathogens. the aim of this study was to achieve a more specific antigen for serological tests. | 2014 | 25954485 |
| cross-talk between epstein-barr virus and microenvironment in the pathogenesis of lymphomas. | epstein-bar virus (ebv) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. emerging evidence however indicates that this final outcome is also related to the ability of ebv to shape microenvironment making it more conducive to cell transformation. indeed, ebv up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety ... | 2015 | 25953434 |
| clinicopathological study of pulmonary extranodal nature killer/t-cell lymphoma, nasal type and literature review. | malignant tumors of the lung are predominantly derived from epithelial tissue, such as squamous cell carcinoma and adenocarcinoma, while pulmonary lymphatic and hematopoietic tumor is relatively rare. extranodal nk/t-cell lymphoma (enktl), nasal type, originates in nasal and extra-nasal sites anatomically. this distinct non-hodgkin lymphoma is endemic and is characterized by a highly aggressive clinical course and dismal survival outcome. extra-nasal enktl, especially pulmonary enktl, is rare co ... | 2015 | 25953340 |
| epstein-barr virus-positive diffuse large b-cell lymphoma following acute myeloid leukemia: a common clonal origin indicated by chromosomal translocation t(3;4)(p25;q21). | secondary non-hodgkin lymphoma following acute myeloid leukemia (aml) is extremely rare. we here describe a unique case involving a patient who developed epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) during complete remission (cr) of aml. a 75-year-old japanese man was initially diagnosed with aml with maturation (fab m2), bearing chromosomal translocation t(3,4)(p25;q21). after intensive chemotherapy, bone marrow aspiration revealed normal karyotype, and he achieved cr ... | 2015 | 25953309 |
| in-cell infection: bringing uninvited guests. | cell-in-cell structures resulting from live cell engulfment were identified more than 100 years ago, but their physiological significance has remained largely obscure. now ni et al. identify a new role for cell-in-cell structure formation, called "in-cell infection" that spreads epstein-barr virus from infected b cells to epithelial cells, an activity that may predispose to cancer. | 2015 | 25952669 |
| expression of the vault rna protects cells from undergoing apoptosis. | non-protein-coding rnas are a functionally versatile class of transcripts exerting their biological roles on the rna level. recently, we demonstrated that the vault complex-associated rnas (vtrnas) are significantly upregulated in epstein-barr virus (ebv)-infected human b cells. very little is known about the function(s) of the vtrnas or the vault complex. here, we individually express latent ebv-encoded proteins in b cells and identify the latent membrane protein 1 (lmp1) as trigger for vtrna u ... | 2015 | 25952297 |
| primary cutaneous natural killer/t-cell lymphoma of the nasal type: a report of 4 cases in north american patients. | the "nasal" type of primary cutaneous lymphoma with natural killer/t-cell differentiation is rarely encountered outside asia. the authors herein document 4 cases in white, north american individuals between the ages of 39 and 73 years. their skin lesions were located on the legs in 2 cases, and they were multifocal in the other 2 patients. microscopically, each neoplasm manifested as a dense infiltrate of cytologically aberrant lymphocytes in the dermis and subcutis. the lesional cells were angi ... | 2015 | 25952095 |
| effects of tofacitinib on lymphocyte sub-populations, cmv and ebv viral load in patients with plaque psoriasis. | plaque psoriasis is a debilitating skin condition that affects approximately 2% of the adult population and for which there is currently no cure. tofacitinib is an oral janus kinase inhibitor that is being investigated for psoriasis. | 2015 | 25951857 |
| dna damage signaling is induced in the absence of epstein-barr virus (ebv) lytic dna replication and in response to expression of zebra. | epstein barr virus (ebv), like other oncogenic viruses, modulates the activity of cellular dna damage responses (ddr) during its life cycle. our aim was to characterize the role of early lytic proteins and viral lytic dna replication in activation of dna damage signaling during the ebv lytic cycle. our data challenge the prevalent hypothesis that activation of ddr pathways during the ebv lytic cycle occurs solely in response to large amounts of exogenous double stranded dna products generated du ... | 2015 | 25950714 |
| human nk cells activated by ebv(+) lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells. | natural killer (nk) cells recognize and eliminate transformed or infected cells that have downregulated mhc class-i and express specific activating ligands. recent evidence indicates that allogeneic nk cells are useful to eliminate haematological cancer cells independently of mhc-i expression. however, it is unclear if transformed cells expressing mutations that confer anti-apoptotic properties and chemoresistance will be susceptible to nk cells. allogeneic primary human nk cells were activated ... | 2015 | 25949911 |
| phase i trial of adoptively transferred tumor-infiltrating lymphocyte immunotherapy following concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. | adoptive cell therapy (act) for cancers using autologous tumor-infiltrating lymphocytes (tils) can induce immune responses and antitumor activity in metastatic melanoma patients. here, we aimed to assess the safety and antitumor activity of act using expanded tils following concurrent chemoradiotherapy (ccrt) in patients with locoregionally advanced nasopharyngeal carcinoma (npc). twenty-three newly diagnosed, locoregionally advanced npc patients were enrolled, of whom 20 received a single-dose ... | 2015 | 25949875 |
| c-met is a novel tumor associated antigen for t-cell based immunotherapy against nk/t cell lymphoma. | background: the expression of c-met and its ligand hgf plays a critical role in cell proliferation and is involved in numerous malignancies. because c-met expression and its role in nk/t-cell lymphoma remain unclear, we studied the expression and function of c-met in nk/t-cell lymphoma cells. in addition, we investigated the possibility that c-met could function as a tumor-associated antigen for helper t lymphocytes (htls). methods: we evaluated whether hgf and c-met were expressed in nk/t-cell ... | 2015 | 25949874 |
| post-transplant lymphoproliferative disorder: case report and review of susceptibility to ebv in the scottish adult renal transplant pool. | we report a case of high-grade non-hodgkin's lymphoma following epstein-barr virus (ebv) infection in a 38-year-old renal transplant recipient who was successfully treated with rituximab and remains alive 6 years later with reasonable graft function. we subsequently undertook a survey showing that 1.8% of the scottish adult transplant pool are susceptible to ebv infection. though a vaccine for ebv is currently not yet available, routine screening of potential renal transplant recipients for ebv ... | 2009 | 25949287 |
| an uncommon presentation of ebv-driven hlh. primary or secondary? an ongoing dilemma. | haemophagocytic lymphohistiocytosis (hlh) is a potentially fatal syndrome, mainly characterised by dysregulated immune activation. the syndrome is related to a genetic cause, in the classic primary form, or to identified triggers such as infections, malignancy or rheumatological processes, in the classic secondary form. epstein-barr virus (ebv) is the most common agent implicated in hereditary and non-hereditary conditions. we describe a 23-month-old girl who experienced severe clinical deterior ... | 2015 | 25948855 |
| lmp1-induced sumoylation influences the maintenance of epstein-barr virus latency through kap1. | as a herpesvirus, epstein-barr virus (ebv) establishes a latent infection that can periodically undergo reactivation, resulting in lytic replication and the production of new infectious virus. latent membrane protein-1 (lmp1), the principal viral oncoprotein, is a latency-associated protein implicated in regulating viral reactivation and the maintenance of latency. we recently found that lmp1 hijacks the sumo-conjugating enzyme ubc9 via its c-terminal activating region-3 (ctar3) and induces the ... | 2015 | 25948750 |
| k1 and k15 of kaposi's sarcoma-associated herpesvirus are partial functional homologues of latent membrane protein 2a of epstein-barr virus. | the human herpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) are associated with hodgkin's lymphoma (hl) and primary effusion lymphomas (pel), respectively, which are b cell malignancies that originate from germinal center b cells. pel cells but also a quarter of ebv-positive hl tumor cells do not express the genuine b cell receptor (bcr), a situation incompatible with survival of normal b cells. ebv encodes lmp2a, one of ebv's viral latent membrane protein ... | 2015 | 25948739 |
| regulation of latent membrane protein 1 signaling through interaction with cytoskeletal proteins. | latent membrane protein 1 (lmp1) of epstein-barr virus (ebv) induces constitutive signaling in ebv-infected cells to ensure the survival of the latently infected cells. lmp1 is localized to lipid raft domains to induce signaling. in the present study, a genome-wide screen based on bimolecular fluorescence complementation (bifc) was performed to identify lmp1-binding proteins. several actin cytoskeleton-associated proteins were identified in the screen. overexpression of these proteins affected l ... | 2015 | 25948738 |
| expression of interleukin-8, interleukin-10 and epstein-barr viral-load as prognostic indicator in nasopharyngeal carcinoma. | interleukin-8 (il-8) is angiogeneic chemokine that plays a potential role in both development and progression of many human malignancies including nasopharyngeal carcinoma (npc). epstein- barr virus (ebv) is recognized to be an important etiologic agent of npc as the viral gene products are frequently detected in npc tissue along with the elevation of antibody titre to the viral protein (vca-p18+ ebna1) of iga in the majority of patients. elevated plasma of viral load is regarded as an important ... | 2015 | 25948470 |
| late-onset severe chronic active ebv in a patient for five years with mutations in stxbp2 (munc18-2) and prf1 (perforin 1). | severe chronic active epstein-barr virus (caebv) disease is defined as a severe progressive illness lasting 6 months or longer with infiltration of tissues with ebv-positive lymphocytes, markedly elevated levels of ebv dna in the blood, and no known immunodeficiency such as hiv. these patients usually have fever, splenomegaly, lymphadenopathy, and may have markedly elevated ebv antibody titers to viral capsid antigen. although the cause of most cases of severe caebv is unknown, one well-document ... | 2015 | 25947952 |
| the 3d structure of kaposi sarcoma herpesvirus lana c-terminal domain bound to dna. | kaposi sarcoma herpesvirus (kshv) persists as a latent nuclear episome in dividing host cells. this episome is tethered to host chromatin to ensure proper segregation during mitosis. for duplication of the latent genome, the cellular replication machinery is recruited. both of these functions rely on the constitutively expressed latency-associated nuclear antigen (lana) of the virus. here, we report the crystal structure of the kshv lana dna-binding domain (dbd) in complex with its high-affinity ... | 2015 | 25947153 |
| [the age aspects of clinical and morphological features of chronic gastritis viral and bacterial etiology]. | the article contains the results of studies of clinical and morphological features of chronic gastritis of viral and bacterail etiology in age aspects. chronic gastritis when infected with epstein-barr virus in elderly patients has clinical and morphological differences from chronic gastritis associated with helicobacter pylori infection, consisting in significantly lower severity of regenerative changes in the cervical epithelium of the mucous membrane of the body and antrum of the stomach, cer ... | 2014 | 25946850 |
| clinical utility of plasma epstein-barr virus dna and ercc1 single nucleotide polymorphism in nasopharyngeal carcinoma. | single nucleotide polymorphism (snp) of the excision repair cross-complementing group 1 (ercc1) gene has been linked with sensitivity to platinum and radiation. the authors hypothesized that the ercc1 genotype for the snps cytosine-to-thymine substitution at codon 118 (c118t) and cytosine-to-adenine substitution at codon 8092 (c8092a) is prognostic in patients with nasopharyngeal carcinoma (npc) who receive either radiotherapy (rt) or cisplatin plus rt. | 2015 | 25946469 |
| large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. | viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell-mediated and humoral immunity. as a result, many viruses could be reactivated individually or simultaneously. using a multiplex polymerase chain reaction (pcr), we prospectively examined many kinds of viral dnas at a time in 105 patients who underwent allogeneic hematopoietic stem cell transplantation. in total, 591 whole blood samples were collected weekly from pre- to 42 ... | 2015 | 25946433 |
| the elevated pretreatment platelet-to-lymphocyte ratio predicts poor outcome in nasopharyngeal carcinoma patients. | the aim of this study was to evaluate whether the platelet-to-lymphocyte ratio (plr) could be used to predict the prognosis of patients with nasopharyngeal carcinoma (npc). patients (n = 1261) who were diagnosed with nonmetastatic npc between january 2008 and december 2010 were recruited. the peripheral platelet and lymphocyte counts were retrieved, and the plr was calculated. univariate and multivariate cox proportional hazards analyses were used to assess their association with plr: overall su ... | 2015 | 25944165 |
| analysis of prognostic risk factors in children with epstein-barr virus-associated hemophagocytic syndrome. | this study aims to analyze the prognostic risk factors in children with epstein-barr virus-associated haemophagocytic lymphohistiocytosis (ebv-hlh). | 2015 | 25941132 |
| malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents. | haemophagocytic lymphohistiocytosis (hlh) in the context of malignancy is mainly considered a challenge of adult haematology. while this association is also observed in children, little is known regarding inciting factors, appropriate treatment and prognosis. we retrospectively analysed 29 paediatric and adolescent patients for presenting features, type of neoplasm or preceding chemotherapy, treatment and outcome. haemophagocytic lymphohistiocytosis was considered triggered by the malignancy (m- ... | 2015 | 25940575 |
| family history of cancer and risk of pediatric and adolescent hodgkin lymphoma: a children's oncology group study. | family history of lymphoid neoplasm (ln) is a strong and consistently observed hodgkin lymphoma (hl) risk factor, although it has been only marginally examined in pediatric/adolescent patients. here, healthy control children identified by random digit dialing were matched on sex, race/ethnicity and age to hl cases diagnosed at 0-14 years at children's oncology group institutions in 1989-2003. detailed histories were captured by structured telephone interviews with parents of 517 cases and 783 co ... | 2015 | 25940226 |
| antivirus immune activity in multiple sclerosis correlates with mri activity. | the objective of this study was to determine whether reactivation of epstein-barr (ebv) or activation of the anti-ebv immune response correlates with ms disease activity on mr imaging. | 2016 | 25939660 |
| syphilitic hepatitis uncommon presentation of an old scourge. | giant cell hepatitis is a rare entity in adults, accounting for 0.1% to 0.25% of liver disease in adults. postinfantile giant cell hepatitis is often characterized by multinucleated giant cells on liver biopsy and a fulminant hepatitis. | 2015 | 25939121 |
| recent concise viewpoints of chronic active epstein-barr virus infection. | chronic active epstein-barr virus infection (caebv) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. patients with caebv also may have various life-threatening conditions including hematological, neurological, pulmonary, cardiac, digestive tract, ocular and/or dermal disorders. additionally, during the course of illness, they often develop hematological malignancies such as t cell, nk cell or ... | 2015 | 25938379 |
| epstein-barr virus-induced gene 3 (ebi3) polymorphisms and expression are associated with susceptibility to pulmonary tuberculosis. | tuberculosis (tb) remains a major global health problem and host genetic factors play a critical role in susceptibility and resistance to tb. the aim of this study was to identify novel candidate genes associated with tb susceptibility. we performed a population-based case-control study to genotype 13 tag snps spanning epstein-barr virus-induced gene 3 (ebi3), colony stimulating factor 2 (csf2), il-4, interferon beta 1 (ifnb1), chemokine (c-x-c motif) ligand 14 (cxcl14) and myeloid differentiati ... | 2015 | 25937126 |
| cd56-negative extranodal nk/t cell lymphoma should be regarded as a distinct subtype with poor prognosis. | previous results about the clinical and prognostic significance concerning cd56 expression status in extranodal nk/t cell lymphoma (enktl) are controversial due to a small sample size and the heterogeneity nature of this disease. the complete data of 288 patients with early-stage upper aerodigestive tract enktl were retrospectively reviewed. one hundred eighty-three patients (63.5 %) had stage i disease, and the primary tumor site of 204 patients (70.8 %) was in the nasal cavity. sixty patients ... | 2015 | 25935537 |
| a rapid embryonic stem cell-based mouse model for b-cell lymphomas driven by epstein-barr virus protein lmp1. | the epstein-barr virus (ebv) latent membrane protein 1 (lmp1) contributes to oncogenic human b-cell transformation. mouse b cells conditionally expressing lmp1 are not predisposed to b-cell malignancies, as lmp1-expressing b cells are eliminated by t cells. however, mice with conditional b-cell lmp1 expression and genetic elimination of α/β and γ/δ t cells ("clt" mice) die early in association with b-cell lymphoproliferation and lymphomagenesis. generation of clt mice involves in-breeding multip ... | 2015 | 25934172 |
| incidence of epstein-barr virus in syrian women with breast cancer: a tissue microarray study. | epstein-barr virus (ebv) has been recently shown to be present in human breast cancer worldwide, which could play an important role in the initiation and progression of this cancer. in this regard, we aimed to explore the prevalence of ebv in 108 breast cancer tissues from syrian women using polymerase chain reaction (pcr) and tissue microarray (tma) analysis. we found that ebv is present in 56 (51.85%) of breast cancers samples. additionally, we report that the expression of lmp1 gene of ebv is ... | 2015 | 25933186 |
| epstein-barr virus genetic variation in lymphoblastoid cell lines derived from kenyan pediatric population. | epstein-barr virus (ebv) is associated with burkitt's lymphoma (bl), and in regions of sub-saharan africa where endemic bl is common, both the ebv type 1 (ebv-1) and ebv type 2 strains (ebv-2) are found. little is known about genetic variation of ebv strains in areas of sub-saharan africa. in the present study, spontaneous lymphoblastoid cell lines (lcls) were generated from samples obtained from kenya. polymerase chain reaction (pcr) amplification of the ebv genome was done using multiple prime ... | 2015 | 25933165 |
| acute acalculous cholecystitis (aac) in the pediatric population associated with epstein-barr virus (ebv) infection. case report and review of the literature. | epstein barr virus (ebv) is a ubiquitous herpes virus that persists lifelong in normal humans by colonizing memory b cells. infection during childhood is usually asymptomatic. isolated gallbladder wall thickening or hydrops have been reported in patients with ebv infectious mononucleosis. however, acute acalculous cholecystitis is an atypical clinical presentation of primary ebv infection. we present a teenager with acute cholecystitis associated with ebv acute infection. acute acalculous cholec ... | 2015 | 25932972 |
| intravascular nk/t-cell lymphoma: a report of five cases with cutaneous manifestation from china. | intravascular lymphoma is a rare type of lymphoma that frequently affects the skin and is usually of b-cell origin. this lymphoma type is very rare and not recognized as a separate entity in the 2008 world health organization classification of hematopoietic and lymphoid tissue tumors. | 2015 | 25931234 |
| the role of epstein-barr virus infection in the development of autoimmune thyroid diseases. | autoimmune thyroid diseases, including graves' and hashimoto's thyroiditis, are the most frequent autoimmune disorders. viral infection, including epstein-barr virus (ebv), is one of the most frequently considered environmental factors involved in autoimmunity. its role in the development of aitd has not been confirmed so far. | 2015 | 25931043 |
| the pathologic findings of skin, lymph node, liver, and bone marrow in patients with adult-onset still disease: a comprehensive analysis of 40 cases. | adult-onset still disease (aosd) is characterized by fever, skin rash, and lymphadenopathy with leukocytosis and anemia as common laboratory findings. we investigated the characteristic pathologic findings of skin, lymph node, liver, and bone marrow to assist in proper diagnosis of aosd.forty aosd patients were included in the study. the skin (26 patients), lymph node (8 patients), liver (8 patients), or bone marrow biopsies (22 patients) between 1998 and 2013 were retrospectively analyzed. aosd ... | 2015 | 25929927 |
| can epstein-barr virus dna load in nasopharyngeal brushings or whole blood predict recurrent nasopharyngeal carcinoma in a non-endemic region? a prospective nationwide study of the dutch head and neck oncology cooperative group. | this study estimated the value of quantitative measurements of ebv markers in the clinical management of nasopharyngeal carcinoma in a non-endemic area. the aim was to predict prognosis and detect recurrent and residual disease. in 72 patients, ebv dna load in blood and nasopharyngeal brushes, and iga vca-p18 and ebna1 in plasma were measured at different time points. at diagnosis and post-treatment, a cut-off value was used for detecting disease [positive (ppv) and negative (npv) predictive val ... | 2016 | 25929413 |
| [frequency of the occurrence of spliced variants of the messenger rna dr3/lard in herpesviral infection]. | analysis of frequency of the occurrence of membrane and soluble forms of the mrna dr3/lard in blood in herpesviral infection of various etiology was studied. four forms of the mrna dr3/lard were detected with various frequencies in blood cells of healthy volunteers. patients with herpesviral infection of various etiology were studied using rt-pcr. two forms encoded membrane molecules (mrna lard 1a, mrna dr3beta) and two other forms accorded soluble forms of receptor (mrna lard 3, mrna soluble dr ... | 2014 | 25929035 |
| cancer risk in the relatives of patients with nasopharyngeal carcinoma—a register-based cohort study in sweden. | little is known about cancer susceptibility among relatives of nasopharyngeal carcinoma (npc) patients in non-endemic areas. we conducted a register-based cohort study to assess the relative risks (rrs) of cancer in families of npc probands in sweden. | 2015 | 25928707 |
| the epstein-barr virus latent membrane protein-1 (lmp1) 30-bp deletion and xhoi-polymorphism in nasopharyngeal carcinoma: a meta-analysis of observational studies. | epstein-barr virus (ebv) is considered to be closely associated with nasopharyngeal carcinoma (npc), in which ebv-encoded latent membrane protein 1 (lmp1) was found to have an oncogenic role. however, the results published on the lmp1 polymorphism are inconsistent. in the present study, we performed a meta-analysis to determine the frequency of the associations and a more precise association between npc and ebv lmp1 gene variants (30-bp deletion (del)/xhoi-loss). | 2015 | 25927427 |
| new noncoding lytic transcripts derived from the epstein-barr virus latency origin of replication, orip, are hyperedited, bind the paraspeckle protein, nono/p54nrb, and support viral lytic transcription. | we have previously shown that the epstein-barr virus (ebv) likely encodes hundreds of viral long noncoding rnas (vlncrnas) that are expressed during reactivation. here we show that the ebv latency origin of replication (orip) is transcribed bi-directionally during reactivation and that both leftward (oriptls) and rightward (oriptrs) transcripts are largely localized in the nucleus. while the oriptls are most likely noncoding, at least some of the oriptrs contain the bcrf1/vil10 open reading fram ... | 2015 | 25926645 |
| sibship size, birth order and risk of nasopharyngeal carcinoma and infectious mononucleosis: a nationwide study in sweden. | the aetiology of nasopharyngeal carcinoma (npc) remains enigmatic in endemic and non-endemic areas. early-life infection with epstein-barr virus (ebv) may predispose to npc development, whereas delayed primary infection with ebv may cause infectious mononucleosis (im). | 2016 | 25925268 |
| cd20-positive nodal natural killer/t-cell lymphoma with cutaneous involvement. | cd20-positive natural killer (nk)/t-cell lymphoma is extremely rare. we describe a case of a cd20-positive nodal nk/t-cell lymphoma with cutaneous involvement in a 32-year-old man. the patient presented with fever, night sweats, right inguinal lymphadenopathy and multiple violaceous to erythematous nodules and plaques on the back and bilateral legs. immunohistochemical analysis showed diffusely and strongly positive staining for cd3, cd3 epsilon, cd43, cd56, tia-1 and cd20 but negative staining ... | 2015 | 25924981 |
| comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma. | altered patterns of dna methylation are key features of cancer. nasopharyngeal carcinoma (npc) has the highest incidence in southern china. aberrant methylation at the promoter region of tumor suppressors is frequently reported in npc; however, genome-wide methylation changes have not been comprehensively investigated. therefore, we systematically analyzed methylome data in 25 primary npc tumors and nontumor counterparts using a high-throughput approach with the illumina humanmethylation450 bead ... | 2015 | 25924914 |
| ebv-associated lymphoepithelioma-like carcinoma of the pancreas: case report with targeted sequencing analysis. | lymphoepithelioma-like carcinomas are distinctive epithelial derived malignant neoplasms that have a syncytial growth pattern and lymphoid stroma. the majority of tumors with this appearance are epstein barr virus (ebv)-associated. we report a patient with a clinical presentation concerning for lymphoma who was diagnosed with an ebv-associated pancreatic carcinoma with a lymphoepithelioma-like pattern. targeted sequencing analysis showed a molecular profile distinct from conventional ductal aden ... | 2017 | 25922198 |
| epstein-barr virus-targeted therapy in nasopharyngeal carcinoma. | despite successful primary treatment of nasopharyngeal carcinoma (npc), the incidence of distant metastasis remains 25-34 %. treatment options are limited, and survival is poor. intratumoural epstein-barr virus (ebv) was used as treatment target. in npc, ebv is present in a latent state, expressing only few non-immunogenic viral products. gemcitabine and valproic acid can trigger ebv to the lytic state, wherein viral kinases are expressed, making ebv-positive tumour cells susceptible for antivir ... | 2015 | 25920375 |
| [nasopharyngeal carcinoma. brush biopsy with ebv-pcr is suitable as a screening test]. | the nasopharyngeal carcinoma (npc) is closely associated with the epstein-barr virus (ebv) infection. because each tumor cell in a patient regardless of histological subtype contains an identical copy of the viral clone, the virus is easily detectable at early pre-invasive lesions. nevertheless, the nasopharyngeal carcinoma is still usually diagnosed late, often not until they exhibit infested lymph nodes and / or distant metastases have occurred. canadian scientists have now discovered and anal ... | 2015 | 25918767 |
| a case of lymphoepithelioma-like carcinoma in the uterine cervix. | lymphoepithelioma-like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the uterine cervix accounts for 0.7% of all primary cervical uterine neoplasms. associations with epstein-barr virus (ebv) and human papilloma virus (hpv) have been demonstrated in some studies. some investigators suggested that ebv has an important role in the initiation of lymphoepitheliomalike carcinoma in asian women. here we report the case of a 45-year-old j ... | 2015 | 25918614 |
| cellular immunotherapy with ex vivo expanded cord blood t cells in a humanized mouse model of ebv-associated lymphoproliferative disease. | donor lymphocyte infusion is not feasible in recipients of cord blood transplantation. | 2015 | 25917625 |
| [updates on epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly]. | 2015 | 25916649 | |
| [presence of b-cell clones in angioimmunoblastic t cell lymphoma]. | to study the significance of b-cell clones in angioimmunoblastic t cell lymphoma (aitl) and the correlation with epstein-barr virus (ebv) and prognosis. | 2015 | 25916641 |
| [clinicopathologic features and association with epstein-barr virus infection in 235 cases of hodgkin lymphoma from northern china]. | to study the clinicopathologic features of hodgkin lymphoma (hl) occurring in northern china, association with epstein-barr virus (ebv) infection and concordance between ebv protein immunohistochemistry (ihc) and in-situ hybridization (ish). | 2015 | 25916637 |
| in-cell infection: a novel pathway for epstein-barr virus infection mediated by cell-in-cell structures. | epstein-barr virus (ebv) can infect both susceptible b lymphocytes and non-susceptible epithelial cells (ecs). viral tropism analyses have revealed two intriguing means of ebv infection, either by a receptor-mediated infection of b cells or by a cell-to-cell contact-mediated infection of non-susceptible ecs. herein, we report a novel "in-cell infection" mechanism for ebv infection of non-susceptible ecs through the formation of cell-in-cell structures. epithelial cne-2 cells were invaded by ebv- ... | 2015 | 25916549 |
| [allogeneic hematopoietic stem cell transplantation for epstein-barr virus associated hemophagocytic syndrome: a case report and literatures review]. | 2015 | 25916301 | |
| successful treatment of immediate allogeneic myeloablative hematopoietic stem cell transplantation from a hla-mismatched sibling donor for active systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood following primary acute epstein-barr virus infection. | a 22-year-old female was admitted for sustained high fever and diagnosed with systemic epstein-barr virus-positive t-cell lymphoproliferative disease. as her clinical course was so aggressive, she immediately underwent allogeneic myeloablative bone marrow transplantation from an hla-mismatched sibling donor on hospital day 46. the patient has remained in complete remission for 3 years. | 2015 | 25914814 |
| the heat shock protein 90 inhibitor biib021 suppresses the growth of t and natural killer cell lymphomas. | epstein-barr virus (ebv), which infects not only b cells but also t and natural killer (nk) cells, is associated with a variety of lymphoid malignancies. because ebv-associated t and nk cell lymphomas are refractory and resistant to conventional chemotherapy, there is a continuing need for new effective therapies. ebv-encoded "latent membrane protein 1" (lmp1) is a major oncogene that activates nuclear factor kappa b (nf-κb), c-jun n-terminal kinase (jnk), and phosphatidylinositol 3-kinase signa ... | 2015 | 25914683 |
| epstein-barr virus is related with 5-aminosalicylic acid, tonsillectomy, and cd19(+) cells in crohn's disease. | to study anti-epstein-barr virus (ebv) igg antibodies in crohn's disease in relation to treatment, immune cells, and prior tonsillectomy/appendectomy. | 2015 | 25914477 |
| follicular helper t-cell lymphoma: a b-cell-rich variant of t-cell lymphoma. | follicular helper t-cell lymphoma is a recently described variant of t-cell lymphoma sharing the cell of origin with angioimmunoblastic t-cell lymphoma and with primary cutaneous cd4-positive small/medium t-cell lymphoma. to better characterize the morphologic and immunophenotypic features of follicular helper t-cell lymphoma, a series of 4 confidently diagnosed cases are analyzed. the overall morphologic pattern significantly overlaps with that of progressive transformation of germinal centers ... | 2015 | 25913305 |
| features of gastric carcinoma with lymphoid stroma associated with epstein-barr virus. | gastric carcinoma with lymphoid stroma (gcls) is a distinct histologic subtype of gastric cancer that is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. more than 80% of gcls cases are associated with epstein-barr virus (ebv) infection, but it is unclear if the virus affects disease progression. we investigated how ebv infection affects the clinical and pathologic features of gcls, as well as patients' outcomes. | 2015 | 25912839 |
| the role of epstein-barr virus infection in the pathogenesis of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is closely associated with epstein-barr virus (ebv) infection. ebv episomes are detected in almost all npc cells. the role of ebv in npc pathogenesis has long been postulated but remains enigmatic. in contrast to infection of b lymphocytes, ebv infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. ebv infection of normal pharyngeal epithelial cells is predominantly lytic in nature. genetic alterati ... | 2015 | 25910483 |
| [role of viruses with oncogenic potential and their associations in oncogenesis in maxillofacial area]. | the potential role of viruses with oncogenic potential such as human papilloma virus, cytomegalovirus, epstein-barr virus, herpes simplex virus type 1 and 2, herpes virus type 6, in the development of benign and pre-cancerous tumors of maxillofacial region was assessed in the study. we examined 26 patients with tumors in maxillofacial region (skin and mucosa) using molecular-genetic and histological studies of surgically removed neoplasms removed. in 53.8% of the examined samples dna of epstein- ... | 2015 | 25909609 |
| epstein-barr virus-positive nodal t/nk-cell lymphoma: an analysis of 15 cases with distinct clinicopathological features. | nodal peripheral t-cell lymphoma, not otherwise specified, is a heterogeneous entity with variable biologic behavior. we analyze the clinicopathological features of 15 patients with epstein-barr virus-positive (ebv+) nodal t/nk-cell lymphoma, including 9 males and 6 females, with a median age of 64 years. all patients presented with multiple lymphadenopathy with common b symptoms (80%, 12/15) at an advanced ann arbor stage (iii, iv) (87%, 13/15). the international prognostic index was high or hi ... | 2015 | 25907865 |
| [the clinical significance of serum epstein-barr virus-determined nuclear antigen 1 (ebna1)/latent membrane protein 1 (lmp1) assay in patients with nasal type extranodal nk/t-cell lymphoma]. | to explore the clinical significance of the serum epstein-barr virus-determined nuclear antigen 1 (ebna1)/latent membrane protein 1 (lmp1) in patients with extranodal nk/t-cell lymphoma, nasal type (enkl). | 2015 | 25907839 |
| the pten-akt-mtor/rictor pathway in nasal natural killer cell lymphoma is activated by mir-494-3p via pten but inhibited by mir-142-3p via rictor. | nasal natural killer (nk) cell lymphoma (nnl) is an epstein-barr virus-associated lymphoma of cytotoxic nk cell origin. the epstein-barr virus-encoded mir-bart20-5p inhibits t-bet (tbx21), the master transcription factor of cytotoxic nk cells. to further explore the roles of mirnas in nnls, we measured the mirna expression profiles of 36 nnls. mir-21, mir-142-3p, mir-126, mir-451, and mir-494-3p were the top five mirnas with the highest expression levels. by using pathway analysis, we identified ... | 2015 | 25907832 |
| the pros and cons of autophagic flux among herpesviruses. | autophagy has been intensively studied in herpes simplex virus type 1 (hsv-1), a human alphaherpesvirus. the hsv-1 genome encodes a well-known neurovirulence protein called icp34.5. when the gene encoding this protein is deleted from the genome, the virus is markedly less virulent when injected into the brains of animal models. subsequent characterization of icp34.5 established that the neurovirulence protein interacts with becn1, thereby inhibiting autophagy and facilitating viral replication i ... | 2015 | 25905782 |
| the role of aging in idiopathic pulmonary fibrosis. | idiopathic pulmonary fibrosis (ipf) has been gathering interest in recent years and as such this review will focus on the potential contributions that age plays on its onset and prevalence. environmental stress over time caused by the inhalation of foreign substances results in subsequent damage and repair of lung tissue. this damage prematurely causes a decrease in stem cell differentiation potential. in conjunction with declining proliferation, the correlation between age and general attenuati ... | 2015 | 25903793 |