Publications

porcine circovirus 2-associated disease in eurasian wild boar.	porcine circovirus 2 (pcv2) was first identified in high-health herds of domestic swine and was associated with a debilitating disease called postweaning multisystemic wasting syndrome (pmws). most subsequent studies have indicated that pcv2 infects only swine but there is little information on porcids other than improved breeds of domestic swine. multisystemic disease was reported in a group of eurasian wild boars raised under free-range conditions. affected young pigs had pneumonia and enterit ...	2003	12918819
a cattle-human comparative map built with cattle bac-ends and human genome sequence.	as a step toward the goal of adding the cattle genome to those available for multispecies comparative genome analysis, 40,224 cattle bac clones were end-sequenced, yielding 60,547 sequences (bac end sequences, bess) after trimming with an average read length of 515 bp. cattle bacs were anchored to the human and mouse genome sequences by blastn search, revealing 29.4% and 10.1% significant hits (e < e-5), respectively. more than 60% of all cattle bes hits in both the human and mouse genomes are l ...	2003	12902387
risk analysis of the spread of classical swine fever virus through "neighbourhood infections" for different regions in belgium.	risk factors associated with the occurrence of "neighbourhood infections" [epidemiology of classical swine fever. in: truszczynski, m. (ed.), proceedings of the workshop on diagnostic procedures and measures to control classical swine fever in domestic pigs and the european wild boar. pulaway, poland, pp. 119-130] during classical swine fever (csf) outbreaks were examined based on information collected during a csf-epidemic, which occurred in the east flanders province of belgium in 1994. the on ...	2003	12900147
long-term effect of retinal ganglion cell axotomy on the histomorphometry of other cells in the porcine retina.	to determine the effect of retinal ganglion cell axotomy on the thickness of inner plexiform, inner nuclear, and outer plexiform layers, as well as the densities of short- and middle-to-long-wavelength cones, in the porcine retina.	2003	12897575
sutureless laparoscopic heminephrectomy using laser tissue soldering.	widespread application of laparoscopic partial nephrectomy has been limited by the lack of a reliable means of attaining hemostasis. we describe laser tissue welding using human albumin as a solder to control bleeding and seal the collecting system during laparoscopic heminephrectomy in a porcine model.	2003	12885354
serial intravascular ultrasonographic measurements after implantation of biodegradable polymer-coated stents in porcine coronary arteries.	biodegradable stent coatings provide a potential for local drug delivery at the time of vascular injury, while possible tissue toxicity is avoided through constant degradation, leaving behind a bare metal stent.	2003	12878907
loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways.	there are several approaches for developing new antiallergic/antiasthmatic agents. one of them is the improvement of an existing class of effective drug classes. due to some undesired effects of intranasal or inhaled corticosteroids, there is a need for better tolerated corticosteroids. loteprednol etabonate belongs to the so-called class of soft steroids because it is metabolized by a one-step reaction (hydrolysis) without using the cytochrome p450 monooxygenase system. in in vitro investigatio ...	2000	12861354
melanocortin receptor variants with phenotypic effects in horse, pig, and chicken.	the melanocortin system is of considerable interest in domestic animals because their energy metabolism and pigmentation have been under strong selection. this article reviews our work on mc1r variants in horse, pig, and chicken, as well as a study on mc4r polymorphism in the pig. the chestnut coat color in horses is caused by an mc1r missense mutation (s83f). in the pig, we have described seven mc1r alleles controlling four different coat color phenotypes (wild type, dominant black, black spott ...	2003	12851331
simple and accurate assessment of forward cardiac output by use of 1-(11)c-acetate pet verified in a pig model.	dynamic 1-(11)c-acetate pet (ac-pet) allows quantification of myocardial blood flow and oxidative metabolism. we wanted to determine the accuracy of ac-pet in measuring cardiac output (co) using first-pass analysis and the indicator dilution principle. further, we wanted to investigate the pulmonary uptake of acetate in relation to left atrial filling pressures and ventricular function.	2003	12843234
feasibility of laparoscopic partial nephrectomy using pledgeted compression sutures for hemostasis.	to develop a technique for laparoscopic partial nephrectomy (lpn) without the use of hilar occlusion that allows large renal resection and excellent hemostasis.	2003	12816585
use of bipolar laparoscopic forceps to occlude and transect the retroperitoneal vasculature: a porcine model.	surgical clips are commonly employed during laparoscopic radical nephrectomy to ligate perihilar vessels reliably, yet these clips can interfere with the application of a vascular stapler to major vessels, potentially leading to catastrophic hemorrhage. we assessed the efficacy of the plasmakinetic trade mark (pk) bipolar cutting forceps (gyrus medical, minneapolis, mn) as a single modality in coagulating and dividing the retroperitoneal vessels in a swine model.	2003	12803992
detection of organ ischemia during hemorrhagic shock.	in a porcine hemorrhagic shock model we aimed to determine: (a) whether blood flow to the intestine and kidney was more reduced than cardiac output; (b) whether parameters of anaerobic metabolism correlated with regional blood flow; and (c) whether metabolic parameters in intestine, kidney and skeletal muscles detected a compromised metabolic state at an earlier stage than did systemic parameters.	2003	12803584
stroke volumes and end-tidal carbon dioxide generated by precordial compression during ventricular fibrillation.	the objective of this study was to measure stroke volumes produced by precordial compression during cardiopulmonary resuscitation and to quantitate relationships of stroke volume to measurements of end-tidal carbon dioxide.	2003	12794425
magnetic resonance imaging of targeted catheter-based implantation of myogenic precursor cells into infarcted left ventricular myocardium.	this study was designed to test the hypothesis that myocardial implantation of myogenic precursor cells (mpc) loaded with iron oxide can be reliably detected in vivo by cardiac magnetic resonance imaging (mri).	2003	12767674
effects of prenatal stress on corticosteroid receptors and monoamine concentrations in limbic areas of suckling piglets (sus scrofa) at different ages.	the present study was conducted in order to reveal the effects of prenatal stress on the central stress regulation in domestic pigs by measuring changes in corticosteroid receptor binding and monoamine concentrations in different limbic brain regions. pregnant sows were subjected to a restraint stress for 5 min daily during the last 5 weeks of gestation. maternal stress resulted in a significantly higher number of glucocorticoid receptors in the hippocampus, but decreased glucocorticoid receptor ...	2003	12757550
biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?	to develop and test a new concept of the degradation kinetics of newly developed coronary stents consisting of magnesium alloys.	2003	12748224
intramural delivery of recombinant apolipoprotein a-imilano/phospholipid complex (etc-216) inhibits in-stent stenosis in porcine coronary arteries.	we have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein a-imilano (apoa-im)/phospholipid complex. in this study, we sought to determine the effects of local recombinant apoa-im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (etc-216) delivered intramurally via the infiltrator catheter on luminal narrowing in a porcine coronary artery stent overstretch injury model.	2003	12742990
effect of combining nicotinamide as a pars-inhibitor with selective inos blockade during porcine endotoxemia.	to investigate the effects of combined selective inducible nitric oxide synthase (inos) inhibition using 1400 w with nicotinamide (nad) as a pars-inhibitor on hepato-splanchnic hemodynamics, o(2) kinetics, and energy metabolism during hyperdynamic porcine endotoxemia.	2003	12739012
robotically assisted laparoscopic dismembered pyeloplasty: a chronic porcine study.	to evaluate the feasibility and efficacy of robotically assisted laparoscopic dismembered pyeloplasty in an animal model. we also investigated whether the use of a device that lacks tactile feedback results in tissue damage and subsequent stenosis or leaking of the anastomosis.	2003	12736048
in vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction.	we investigated the potential of magnetic resonance imaging (mri) to track magnetically labeled mesenchymal stem cells (mr-mscs) in a swine myocardial infarction (mi) model.	2003	12732608
classical swine fever in wild boar in the lombardy region of italy from 1997 to 2002.	in 1997, outbreaks of classical swine fever occurred in wild boar and domestic pigs in the italian province of varese (lombardy region). statutory animal health measures were imposed, and a control plan aimed at preventing the virus from spreading outside the infected hunting zone of 108 km2 was implemented. however, in 1998, virologically positive wild boar were found outside this zone, including within swiss territory. the infected zone was then enlarged to include the three other hunting area ...	2003	12723629
[an acute hepatitis case domestically infected with a hepatitis e virus whose nucleotide sequence showed a high similarity to that from a domestic swine in japan].		2003	12722353
initial experiences with in vivo intravascular coronary vessel wall imaging.	to evaluate potential use of a loopless internal receiver coil for in vivo coronary artery vessel wall imaging in five domestic swine.	2003	12720273
alterations in bronchoalveolar lavage fluid during ischemia-induced acute hepatic failure in the pig.	the objective of this controlled experimental animal study was to evaluate whether acute hepatic failure (ahf) can cause acute lung injury (ali) and to investigate possible pathophysiologic mechanisms. seventeen domestic pigs were randomly assigned to ahf and sham groups. ahf was induced by surgical devascularization of liver in 10 animals. seven animals were sham operated. hemodynamics, lung mechanics, extravascular lung water (evlw), and intracranial pressure, blood gas, liver function tests, ...	2003	12717394
a novel porcine gammaherpesvirus.	a novel porcine gammaherpesvirus was detected in the blood of domestic pigs by pcr. with degenerate-primer pcr and subsequent long-distance pcr approaches a 60-kbp genome stretch was amplified. sequence analysis revealed the presence of the gammaherpesvirus orfs 03 to 46 as well as a putative chemokine receptor and a v-bcl-2 gene. the 60-kbp sequence was compared with the corresponding sequence of the porcine lymphotropic herpesvirus 1 (plhv-1) published recently and the sequence of plhv-2, whic ...	2003	12706081
large hepatic ablation with bipolar saline-enhanced radiofrequency: an experimental study in in vivo porcine liver with a novel approach.	radiofrequency ablation (rfa) is a relatively new technology for the local destruction of liver tumors. development of recent devices has enabled the creation of larger lesions. nevertheless, treating liver tumors larger than 2.5 cm in diameter often requires multiple overlapping ablations to encompass the tumor and the surrounding healthy tissue rim with an increasing risk of local recurrence.	2003	12697400
characterization of japanese swine and human hepatitis e virus isolates of genotype iv with 99 % identity over the entire genome.	the full-length genomic sequences were determined of japanese swine and human hepatitis e virus (hev) isolates (swj13-1 and he-ja1, respectively) with 100 % identity in the partial sequence of open reading frame (orf) 2 (orf2, 412 nt). swj13-1 was isolated from a 4-month-old farm pig born in hokkaido, japan, in 2002 and he-ja1 was recovered from a 55-year-old patient who lived in hokkaido and who had contracted sporadic acute hepatitis e in 1997. both isolates consisted of 7240 nt, excluding the ...	2003	12692290
effect of post-mortem changes on peripheral and central whole blood and tissue clozapine and norclozapine concentrations in the domestic pig (sus scrofa).	interpretation of the results of psychoactive or other drug measurements in post-mortem blood specimens may not be straightforward, in part because analyte concentrations in blood may change after death. there is also the issue of comparability of plasma (or serum) results to those obtained in whole blood. to investigate these problems with respect to clozapine, this drug (10mg/kg daily) was given orally to two pigs. blood was collected 3h post-dose on day 7, the animals were sacrificed, and blo ...	2003	12689746
segmental nature of the porcine liver and its potential as a model for experimental partial hepatectomy.	in-depth knowledge of pig liver anatomy allows potential research into segmental liver resections and hepatic regeneration, as well as liver transplantation techniques. the segmental anatomy, however, remains largely unknown. this study aimed to delineate the segmental anatomy of the porcine liver in comparison with that of the human.	2003	12673745
anatomical and neurochemical features of the extrinsic and intrinsic innervation of the striated muscle in the porcine esophagus: evidence for regional and species differences.	studies of the intrinsic and extrinsic innervation patterns of esophageal motor endplates (meps) are mainly confined to small rodents. therefore, an immunocytochemical, denervation and tracing study was conducted on the pig, an experimental model in which the distribution of the striated esophageal muscle portion more closely resembles the human situation. the purpose of this study was to analyze the origin and neurochemical content of the nerve fibers participating in the myoneural synapse. fif ...	2003	12658437
histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography.	to compare ultrahigh-resolution optical coherence tomography (oct) cross-sectional images of the pig retina with histology, to evaluate the potential of ultrahigh-resolution oct for enhanced visualization of intra- and subretinal structures.	2003	12657611
studies of the transmissibility of the agent of bovine spongiform encephalopathy to pigs.	studies to test the transmissibility of the bovine spongiform encephalopathy (bse) agent to pigs began in 1989. parenteral inoculation of the agent by three routes simultaneously (intracranially, intravenously and intraperitoneally) produced disease with an incubation period range of 69-150 weeks. pre-clinical pathological changes were detected in two pigs killed electively at 105 and 106 weeks post-inoculation. infectivity was detected by bioassay in inbred mice in the cns of those pigs that de ...	2003	12655106
1-molar gadobutrol as a contrast agent for computed tomography: results from a comparative porcine study.	to evaluate prospectively the efficacy of gadobutrol as contrast agent for computed tomography (ct) compared with iodinated contrast media in a porcine animal model.	2003	12649642
in vivo validation of cardiac spiral computed tomography using retrospective gating.	cardiac functional assessment represents the basis for diagnostics and cardiac operation planning. spiral computed tomography (ct) combines the advantages of three-dimensional imaging and high temporal resolution when using gating techniques. however, in vivo validation data of this novel imaging technology are lacking. the purpose of this study was to validate in vivo the new imaging method using retrospective gating and to evaluate the clinical usefulness of the achieved temporal resolution.	2003	12645712
effects of cryoablation on short-term development of urinary fistulas in the porcine kidney.	to determine the effect of cryoablation on the collecting system in the porcine kidney and the possible development of pelvic injury or fistula.	2003	12639360
creation of ureteropelvic junction obstruction and its correction by chemical glue-assisted laparoscopic dismembered pyeloplasty.	we established a porcine model of ureteropelvic junction (upj) obstruction using a laparoscopic technique and assessed the outcome of standard suture-assisted and chemical glue-assisted laparoscopic pyeloplasty.	2003	12639357
nipah virus outbreak in malaysia.	nipah virus, a novel paramyxovirus, closely related to hendra virus emerged in northern part of peninsular malaysia in 1998. the virus caused an outbreak of severe febrile encephalitis in humans with a high mortality rate, whereas, in pigs, encephalitis and respiratory diseases but with a relatively low mortality rate. the outbreak subsequently spread to various regions of the country and singapore in the south due to the movement of infected pigs. nipah virus caused systemic infections in human ...	2003	12637075
outbreak of trichinellosis in cáceres, spain, december 2001-february 2002.	an outbreak of trichinellosis by t. britovi occured in cáceres, spain, between 18 december 2001 and 11 february 2002, following the consumption of insufficiently cooked meat from a domestic pig. among the 56 people exposed, 26 cases of trichinellosis were diagnosed, of which 17 serologically confirmed. the mean incubation period was 23.5 days (3-45). among the foodstuffs suspected, salami-type sausages were associated with an attack rate of 93.3% (14/15), and a dose-response relationship was obs ...	2002	12631992
standardized qualitative evaluation of scar tissue properties in an animal wound healing model.	there is a great need to establish reproducible methods for evaluative studies of wound treatment and wound healing. validation of the healing process through optical techniques, as well as histologic and immunohistochemical methodologies, have been improved and to some extent have become well-established assays. data relating to biomechanical properties, e.g., evaluation of the tensile strength of scar tissue that forms in experimental wound treatment strategies, are less widely available. we c ...	2003	12631304
hypertonic saline improves myocardial blood flow during cpr, but is not enhanced further by the addition of hydroxy ethyl starch.	to evaluate the effects of hypertonic saline (hs) and/or hydroxy ethyl starch (hes) on myocardial perfusion pressure (mpp) and blood flow (mbf), and cardiac index (ci) during and after cardiopulmonary resuscitation (cpr).	2003	12628562
the effect of body weight on the degree of blood velocity profile skewness in the aortic annulus in domestic pigs.	we investigated the blood velocity profile in the aortic annulus (aa) in two groups of domestic pigs using epicardial doppler echocardiography. the velocity profile skewness in terms of max/mean tvi (the ratio of maximal to cross-sectional mean time-velocity integral along the diameter) was 1.107 +/- 0.01 in the small pigs (n = 10; body weight: 24.6 +/- 0.8 kg) and 1.216 +/- 0.026 in the large pigs (n = 8; body weight: 50.6 +/- 2.5 kg) (p = 0.002). the velocity profile in the aa is more skewed i ...	2003	12626075
invasive and non-invasive evaluation of spontaneous arteriogenesis in a novel porcine model for peripheral arterial obstructive disease.	our current knowledge regarding the efficacy of factors stimulating collateral artery growth in the peripheral circulation primarily stems from models in small animals. however, experimental models in large sized animals are a prerequisite for extrapolation of growth factor therapy to patients with peripheral atherosclerotic obstructive disease. therefore, we have developed a novel porcine femoral artery ligation model using non-invasive and invasive evaluation techniques. in 12 young farm pigs ...	2003	12618266
clinical signs and epidemiology of classical swine fever: a review of new knowledge.	although classical swine fever (csf) has been well known for decades and epidemics still occur, clinical diagnosis continues to cause problems for veterinary practitioners. this is due to the extensive differential diagnosis, further complicated by the emergence of new diseases such as porcine reproductive and respiratory syndrome (prrs) and porcine dermatitis and nephropathy syndrome (pdns). in addition, acute, chronic and prenatal courses of csf have to be distinguished. as a cause of consider ...	2003	12618065
identification of goose, mule duck, chicken, turkey, and swine in foie gras by species-specific polymerase chain reaction.	a specific polymerase chain reaction (pcr) has been developed for the identification of goose (anser anser), mule duck (anas platyrhynchos x cairina moschata), chicken (gallus gallus), turkey (meleagris gallopavo), and swine (sus scrofa domesticus) in foie gras. a forward common primer was designed on a conserved dna sequence in the mitochondrial 12s ribosomal rna gene (rrna), and reverse primers were designed to hybridize on species-specific dna sequences of each species considered. the differe ...	2003	12617577
an animal model of abdominal aortic aneurysm created with peritoneal patch: technique and initial results.	the purpose of this study was to develop an abdominal aortic aneurysm model that more closely resembles the morphology of human aneurysms with potential for further growth of the sac. an infrarenal abdominal aortic aneurysm (aaa) model was created with a double-layered peritoneal patch in 27 domestic swine. the patch, measuring in average from 6 to 12 cm in length and from 2 to 3 cm in width, was sutured to the edge of an aortotomy. pre- and postsurgical digital subtraction aortograms (dsa) were ...	2003	12616417
vasopressin, but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs.	the authors compared the effects of vasopressin fluid resuscitation on survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs.	2003	12606914
early degradation of paternal mitochondria in domestic pig (sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and mg132.	ubiquitin-dependent proteolysis has been implicated in the recognition and selective elimination of paternal mitochondria and mitochondrial dna (mtdna) after fertilization in mammals. initial evidence suggests that this process is contributed to by lysosomal degradation of the ubiquitinated sperm mitochondrial membrane proteins. the present study examined the role of the proteasome-dependent protein degradation pathway of the ubiquitin system, as opposed to lysosomal proteolysis of the ubiquitin ...	2003	12606393
[biomechanical properties (compressive strength and compressive pressure at break) of hyaline cartilage under axial load].	explanations concerning the physical properties of hyaline cartilage are different. it was the intention of this study to determine the material parameters of hyaline cartilage under axial load (elasticity, plasticity, elasticity and module pressure stress to break).	2003	12594619
mechanisms of inducible nitric oxide synthase (inos) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia.	to determine the mechanisms of improved gut mucosal acidosis associated with selective inducible nitric oxide synthase (inos) inhibition.	2003	12594592
[interstitial t1-weighted mr lymph fistulography with gadomer-17 in an experimental animal model].	to visualize and localize fistulas of the thoracic duct with interstitial t 1 -weighted mr lymphography using gadomer-17.	2003	12584631
reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.	knowledge of the biotransformation processes of veterinary drugs and food supplements in food-producing animals is increasingly important. residual levels of parent compounds or their metabolites in food of animal origin may differ with the breed, breeding conditions, and gender of animals. the nonsteroidal antiinflammatory drug flobufen, 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (racemic or its individual enantiomers) was used as a model to evaluate differences in activity, st ...	2003	12582986
perivascular endothelial implants inhibit intimal hyperplasia in a model of arteriovenous fistulae: a safety and efficacy study in the pig.	vascular access complications are a major problem in hemodialysis patients. native arteriovenous fistulae, historically the preferred mode of access, have a patency rate of only 60% at 1 year. the most common mode of failure is due to progressive stenosis at the anastomotic site. we have previously demonstrated that perivascular endothelial cell implants inhibit intimal thickening following acute balloon injury in pigs and now seek to determine if these implants provide a similar benefit in the ...	2002	12566978
the effect of birth weight on hypothalamo-pituitary-adrenal axis function in juvenile and adult pigs.	programming of the hypothalamo-pituitary-adrenal (hpa) axis during prenatal and early postnatal life may explain, in part, the association between low birth weight (bw) and the increased incidence of cardiovascular and metabolic disease in later life. this study examined the effect of natural variations in bw on hpa axis function in juvenile and adult pigs. low (< 1.47 kg) and high (> 1.53 kg) bw pure-bred large white piglets from 15 litters were studied at 3 (n = 47) and 12 (n = 17) months of a ...	2003	12562947
pathogenicity and kinetics of virus propagation in swine infected with the cytopathogenic classical swine fever virus containing defective interfering particles.	to analyze the pathogenicity and in vivo kinetics of the cytopathogenic (cp) classical swine fever virus (csfv) wb82 strain, which is composed of cp defective interfering (di) particles and noncytopathogenic (noncp) helper virus (wb82/e(+) strain), wb82 and wb82/e(+) strains were administered separately to domestic pigs. after inoculation with either strain, all pigs showed typical symptoms of classical swine fever (csf), such as leucopenia and high fever. there were few differences in clinical ...	2003	12556994
evaluation of a vessel sealing system, bipolar electrosurgery, harmonic scalpel, titanium clips, endoscopic gastrointestinal anastomosis vascular staples and sutures for arterial and venous ligation in a porcine model.	we assessed the usefulness of the ligasure (valleylab, boulder, colorado) vessel sealing system for vascular control during laparoscopic surgery and compared it with other available hemostatic modalities.	2003	12544345
laparoscopic partial nephrectomy with a diode laser: porcine results.	to develop a safe and effective technique for laparoscopic partial nephrectomy without need for hilar occlusion.	2002	12542878
near-infrared fluorescence coronary angiography: a new noninvasive technology for intraoperative graft patency control.	intraoperative graft patency verification is of major clinical importance for quality control after coronary artery bypass grafting (cabg), especially if surgery is performed on the beating heart. this is one of the first reports of fluorescence coronary angiography (fca) using the dye indocyanine green (icg), a noninvasive technology for direct visualization of coronary arteries, bypass grafts, and myocardial perfusion.	2002	12538119
liver sinusoidal endothelial cells represents an important blood clearance system in pigs.	background: numerous studies in rats and a few other mammalian species, including man, have shown that the sinusoidal cells constitute an important part of liver function. in the pig, however, which is frequently used in studies on liver transplantation and liver failure models, our knowledge about the function of hepatic sinusoidal cells is scarce. we have explored the scavenger function of pig liver sinusoidal endothelial cells (lsec), a cell type that in other mammals performs vital eliminati ...	2003	12537582
direct intrahepatic portacaval shunt: an experimental study.	to determine the feasibility of creating direct intrahepatic portacaval shunt (dips) in swine with puncture under sonographic guidance.	2003	12532459
preparation and analysis of spermatocyte meiotic pachytene bivalents of pigs for gene mapping.	well-spread meiotic pachytene bivalents were obtained by using the prolonged hypotonic treatment combined with high chloroform carnory's fixative solution from cells of the testes of domestic pigs. comparison in the division index and length of pachytene bivalents with metaphase chromosomes showed that those of the former are 5 times higher and 3.42(1.87-5.98) times longer than those of the latter. comparative studies on chromomere maps of bivalents and mitotic chromosomal g-bands were conducted ...	2002	12528898
bacteriological and genetic assessment of game meat from japanese wild boars.	bacterial tests were used to assess bacterial contamination of game meat from japanese wild boars. the bacterial contamination of wild boar meat was less than that of domestic pork, as determined by aerobic plate counts (apc) and coliform counts. none of the meat examined in this study was contaminated by salmonella or e. coli o-157. to detect adulteration by domestic pig meat or european wild boar meat, 46 samples of game meat sold as japanese wild boar were examined genetically. a total of 17 ...	2003	12517093
[modulation of nerve growth factor on wound healing of burn].	to investigate the effect of nerve growth factor(ngf) on the burn wound healing and to study the mechanism of burn wound healing.	2000	12516472
magnetic resonance image-guided transcatheter closure of atrial septal defects.	recent developments in cardiac mri have extended the potential spectrum of diagnostic and interventional applications. the purpose of this study was to test the ability of mri to perform transcatheter closures of secundum type atrial septal defects (asd) and to assess asd size and changes in right cardiac chamber volumes in the same investigation.	2003	12515755
a case of anaemia in a neonatal warthog (phacochoerus aethiopicus) and evaluation of serum-soluble iron in warthogs.	a 38-day-old male warthog (phacochoerus aethiopicus) with marked anaemia (haematocrit = 14 %) presented to the denver zoological gardens hospital with ataxia, tachypnoea, suspected stunted growth and cardiomegaly. the piglet demonstrated some features consistent with both iron deficiency anaemia and autoimmune haemolytic anaemia. serum-soluble iron was below the level of detection (< 8.96 micromol/l). iron deficiency anaemia is a well recognised entity in domestic swine reared on concrete and de ...	2002	12515305
transluminal stent graft repair with wallgraft endoprosthesis in a porcine arteriovenous graft pseudoaneurysm model.	pseudoaneurysm is a known complication of arteriovenous grafts in chronic hemodialysis and can result in graft disruption or thrombosis if left untreated. this study evaluated the safety and efficacy of endovascular repair with wallgraft endoprosthesis (boston scientific, inc, watertown, mass) in a porcine arteriovenous graft (avg) pseudoaneurysm model. materials and methods: bilateral groin avg pseudoaneurysms (n = 18) were created with an oversized dacron interposition graft within a polytetra ...	2003	12514597
distribution of primary afferent neurons associated with the porcine inferior mesenteric ganglion (img).	the existence of afferent neurons supplying img nerve cells by their collaterals has previously been demonstrated in laboratory animals, where these fibers constitute an important part of intraganglionic nerve input involved in the regulation of autonomic neurons activity. the domestic pig is thought to be a reliable animal model for medical and biomedical studies, especially those dealing with the organization of nerve pathways contributing to the neural control of the bowel and lower urinary t ...	2002	12502188
variation in mitochondrial dna of vietnamese pigs: relationships with asian domestic pigs and ryukyu wild boars.	mitochondrial dna (mtdna) sequences (574 bp) of 30 vietnamese pigs (large and small) were examined and compared with those of 61 haplotypes from wild boars and domestic pigs from various locations in asia. the large vietnamese pigs had genetic links to ryukyu wild boars in southern japan. the small vietnamese pigs were closely related to other east asian domestic pigs. these results indicate that vietnamese pigs are genetically diverse and may be descendents of wild and domestic pigs from other ...	2002	12499677
a genetic method to distinguish crossbred inobuta from japanese wild boars.	to distinguish pig-wild boar crossbred inobuta from japanese wild boar populations, a genetic method by using mitochondrial dna (mtdna) haplotypes and the nuclear glucosephosphate isomerase-processed pseudogene (gpip) was developed. sixteen mtdna haplotypes from 152 wild boars from kyushu, shikoku and honshu islands of japan were distinct from those from asian and european domestic pigs. five alleles of gpip were classified into two groups: 1). alleles gpip1, gpip3 and gpip*3a from japanese wi ...	2002	12499675
ginkgo biloba extract egb 761 attenuates myocardial stunning in the pig heart.	myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. the objective of the present study was to determine whether the ginkgo biloba extract egb761, which has antioxidant properties in vitro, can attenuate myocardial stunning in vivo. forty-seven anesthetized open-chest farm pigs underwent 10 min of occlusion of the left anterior descending coronary artery (lad), followe ...	2003	12494270
laparoscopic partial nephrectomy with a novel electrosurgical snare in a porcine model.	we evaluated the safety and efficacy of laparoscopic partial nephrectomy with an arcing-gap electrosurgical snare in a porcine model.	2002	12490022
primary stability of various implants in tibial opening wedge osteotomy: a biomechanical study.	high tibial osteotomy (hto) is an established method for treating varus gonarthrosis. the opening wedge hto has some advantages over the lateral closed wedge technique. in this biomechanical study various systems of internal fixation of medial hto were compared using an animal cadaver model (lower leg specimens from 1-year-old female domestic pigs). the first osteotomy (10 degrees ) was carried out and stabilized with a c-plate, an arthrex spacer plate, or an ao tibial plate with or without bone ...	2002	12486473
stroke volumes generated by precordial compression during cardiac resuscitation.	to quantitate stroke volumes generated by precordial compression during cardiopulmonary resuscitation and to determine their relationship to coronary perfusion pressure and the success of resuscitation.	2002	12483049
[the development of the relationship between sow and piglet in the domestic pig--a sociobiological observation].	the nursing and suckling behaviour of the domestic pig is a complex social behavioural interaction aimed to ensure the milk flow from the sow to the piglets. ultimately caused theoretical frameworks from basic ethology and/or sociobiology are increasingly used to explain such social behavioural patterns. the present paper gives a short survey of ethophysiological aspects of the nursing and suckling behaviour in domestic pigs and, thereafter, discusses the development and consequences of some par ...	2002	12481652
[skin layer thickness at the ear of the domesticated pig , with special reference to the use of the ear integument for human dermatological research].	based on a shrinkage-free methodical approach (special plastic resin embedding, frozen section technique) and histological routine staining, the thickness of the different skin layers was measured from 15 regions of the outer and the inner side of the porcine auricle. mean thickness values were for the str. corneum: 19 microns outside/20 microns inside, vital epidermis without ridges: 52 microns outside/56 microns inside, dermis: 1175 microns outside/1112 microns inside, hypodermis: 1024 microns ...	2002	12481644
laparoscopic interstitial laser coagulation of renal tissue with and without hilar occlusion in the porcine model.	to evaluate the safety and efficacy of interstitial laser coagulation (ilc), applied via a laparoscopic approach, with and without hilar occlusion in the porcine model.	2002	12470463
evidence that rodents are a reservoir of hepatitis e virus for humans in nepal.	hepatitis e virus (hev) is an important cause of enterically transmitted hepatitis in developing countries. sporadic autochthonous cases of hepatitis e have been reported recently in the united states and other industrialized countries. the source of hev infection in these cases is unknown; zoonotic transmission has been suggested. antibodies to hev have been detected in many animals in areas where hev is endemic and in domestic swine and rats in the united states. there is evidence supporting h ...	2002	12454141
in vivo study of bacterial adhesion to five types of intraocular lenses.	to determine in vivo behavior of the ability of the staphylococcus epidermidis strain (american type culture collection [atcc] 14990) to attach to 120 intraocular lenses (iols) made of five different biomaterials: fluorine polymethylmethacrylate (pmma), heparinized pmma, silicone, hydrophobic acrylic, and hydrogel. the pig was chosen as an animal model of endophthalmitis, after a bibliographical analysis and a personal study of its aqueous humor composition.	2002	12454042
therapeutic effects of cooling swine skin exposed to sulfur mustard.	recent world events have highlighted the need for effective medical therapies for chemical weapon injuries. of the chemical weapon agents, perhaps one of the most widely used, both historically and most recently in the iran-iraq war, is sulfur mustard (hd). no effective antidotes exist for this vesicant agent and, to this day, hd casualties are treated entirely symptomatically. previous work carried out in this laboratory has indicated that cooling hd-exposed tissue may ameliorate the resultant ...	2002	12448623
aggressive venous neointimal hyperplasia in a pig model of arteriovenous graft stenosis.	vascular access dysfunction is the most important cause of morbidity and hospitalization in the hemodialysis population in the united states at a cost of well over one billion dollars per annum. venous neointimal hyperplasia characterized by stenosis and subsequent thrombosis, is the major cause of polytetrafluoroethylene (ptfe) dialysis graft failure. despite the magnitude of the problem, there are currently no effective therapies for the prevention or treatment of venous neointimal hyperplasia ...	2002	12427156
a porcine coronary stent model of increased neointima formation in the left anterior descending coronary artery.	clinical trials suggest an increased frequency of restenosis after coronary intervention in left anterior descending (lad) compared to the left circumflex or right coronary arteries. experimental studies correlate stent-induced arterial injury and the extent of neointima formation. this study investigates whether the coronary artery affects the relationship between arterial injury and neointima hyperplasia in the porcine stent model.	2002	12426824
temporal relationship of hippocampal liquor- and plasma-cortisol-concentrations in the domestic pig challenged with synthetical adreno-corticotrophic hormone.	the concentration of plasma and intracerebral cortisol in pigs challenged with 0.5 iu adrenocorticotrophic hormone/kg body weight was simultaneously measured at a 30 min rate. the pigs (n=5) were provided with indwelling jugular vein catheters and guide canullas for insertion of a hippocampal microdialysis probe. every five blood samples taken at 6 min intervals were pooled to simulate the 30 min collection time of the microdialysis. stimulation resulted in an increment of cortisol of roughly 20 ...	2002	12419495
renal hypothermia achieved by retrograde intracavitary saline perfusion.	hypothermia during vascular clamping protects the kidney from ischemia-induced nephron loss. traditionally, cooling is achieved by packing the kidney in ice, which lowers the temperature of the rest of the surgical field as well, and the method cannot be used during laparoscopy. we evaluated the utility of a newly developed ureteral access system for circulating ice-cold saline.	2002	12396435
after the 'affluent society': cost of living in the papua new guinea highlands according to time and energy expenditure-income.	what is the cost of living in the papua new guinea highlands? an answer is sought using a time and energy accounting approach. the subsistence regime of wola-speaking highlanders, the subjects of this investigation, comprises three components. the principal one is horticulture: people clearing gardens from forest and grassland, with tuberous crops predominating, notably sweet potato. the second component comprises animal rearing, notably of domestic pigs. the third, and least important, is hunti ...	2002	12395862
a porcine model of the abdominal compartment syndrome.	the purpose of this study was to investigate whether an intra-abdominal pressure (iap) of 30 mmhg lasting 24 h in a porcine model will lead to a condition comparable with the abdominal compartment syndrome (acs) in humans. we examined 12 intubated and anesthetized domestic pigs with a mean body weight of 52.5 +/- 4.9 kg. using a co2 pneumoperitoneum, the iap was increased to 30 mmhg (study group, n = 6) for an investigation period of 24 h. in the control group, the iap remained unchanged. invest ...	2002	12392274
the axillocoronary bypass. blood flow and short-term graft histology in a porcine model.	bypass grafts arising from the axillary artery may be indicated for complications during minimally invasive direct coronary artery bypass grafting, for redo operations and for management of a severely atherosclerotic ascending aorta. as basic data research on this technique is scanty, we investigated intraoperative function and postoperative morphology of axillocoronary bypass grafts in a porcine model.	2002	12386573
a review of mutual transmission of important infectious diseases between livestock and wildlife in europe.	oral vaccination of red foxes against rabies has been practiced in europe since 1978 and has succeeded in greatly reducing the occurrence of this disease in foxes: this is an example of coordinated activity against a disease that affects both wild and domestic animals as well as humans. some examples of diseases that affect both domestic and wild animals in europe are: classical swine fever (hog cholera) in wild boars and domestic swine; myxomatosis and rabbit hemorrhagic disease in domestic and ...	2002	12381556
cellular and vascular reactions in the liver to radio-frequency thermo-ablation with wet needle applicators. study on juvenile domestic pigs.	the aim of this animal experiment was to investigate the cellular and vascular reactions in the liver of juvenile domestic pigs produced by a radio-frequency thermoablation (rfta) applicator perfused with saline solution.	2002	12364820
pulmonary gas exchange after cardiopulmonary resuscitation with either vasopressin or epinephrine.	it is well established that epinephrine administered during cardiopulmonary resuscitation results in pulmonary gas exchange disturbances. it is uncertain how vasopressin affects gas exchange after cardiopulmonary resuscitation.	2002	12352041
influence of development factors on nutritional patterns in the solomon islands.	looks at the general changes brought about by development, and how the nutritional habits of the solomon island communities have been affected by development. the development aspirations of third world countries include the introduction of cash crops for foreign exchange; moving away from subsistence-type economy and self-reliance in feeding one's family to dependence on outside sources; employment of more people at salaried jobs, small industries and factories; and modernization. many governm ...	1981	12265890
evolution of the stone heart after prolonged cardiac arrest.	we hypothesized that progressive impairment in diastolic function during cardiopulmonary resuscitation (cpr) precedes evolution of the "stone heart" after failure of cpr. we therefore measured sequential changes in left ventricular (lv) volumes and free-wall thickness of the heart during cpr in an experimental model.	2002	12226047
effect of inhaled endotoxin on cardiopulmonary function and e-selectin expression in pigs.	to evaluate the effect of controlled exposure to inhaled lipopolysaccharides (lps) on the pulmonary inflammatory response of anesthetized pigs.	2002	12224865
effects of hypertonic saline on myocardial blood flow in a porcine model of prolonged cardiac arrest.	to evaluate the effects of hypertonic saline (hs) on myocardial reperfusion pressure (mpp) and blood flow (mbf), and cardiac index (ci) during and after cardiopulmonary resuscitation (cpr).	2002	12204461
interposition of a jejunal segment as an alternative one-stage operation for acute left colon obstruction.	much debate surrounds the one-stage surgical management of acute left colon obstruction. many surgeons are still reluctant to perform primary anastomosis in unprepared bowel fearing the risk of anastomotic dehiscence. although intraoperative lavage and subtotal colectomy have recently proved effective for preventing fecal loading, both of these procedures have drawbacks and the search for additional alternative surgical procedures continues. we conducted an experimental study to examine a new on ...	2002	12203059
splanchnic and pancreatic tissue perfusion in experimental acute pancreatitis.	gut hypoperfusion has a major role in the pathogenesis of multiple organ failure, which is the main cause of death in severe acute pancreatitis. the effects of experimental acute pancreatitis on splanchnic and pancreatic perfusion and oxygenation were studied to find out whether gut hypoperfusion occurs already at the same time as changes in pancreatic perfusion.	2002	12190101
[investigation on contraction mechanism of expanded tissue].	to investigate the contraction mechanism of expanded tissue.	2002	12189708
immunophenotyping of leukocyte subsets in peripheral blood and palatine tonsils of prefattening pigs.	the quantitative and distribution patterns of porcine peripheral blood and tonsillar lymphoid/myeloid cell subsets were assessed in order to establish the immune status of farm pigs prior to their transfer to fattening units. peripheral blood and tonsillar samples were taken from clinically healthy, nonvaccinated, 12-week-old pigs, either ex vivo or following euthanasia. single-colour flow cytometry, using monoclonal antibodies (mabs) reactive with the swine leukocyte cluster of differentiation ...	2002	12184498
effectiveness of radioactive tungsten source in the prevention of restenosis in stented porcine coronary arteries.	intracoronary radiation has shown the potential to inhibit neointimal proliferation in porcine models of restenosis. the objective of this study was to determine whether intracoronary radiation using a new coiled wire of tungsten-188 ((188)w), a pure beta emitter (half-life 69.4 days) is safe. in addition, a dose of 0 gy, 18 gy, or 25 gy prescribed to 2 mm from the center of the source and delivered intraluminally is sufficient to prevent restenosis and free from adverse effects.	2002	12182999
hormonal changes related to reduced renal blood flow and low urine output under prolonged increased intra-abdominal pressure in pigs.	to investigate effects of prolonged increased intra-abdominal pressure (iap) on diuresis, renal blood flow, and hormones that influence renal function, in particular endothelin.	2002	12182244
thoracoscopic internal mammary sentinel node biopsy: an animal model of a new technique.	the nodal status remains the most important prognostic factor in breast cancer. while evaluation of the axillary lymph nodes remains a standard of practice, evaluation of the internal mammary lymph nodes is no longer routinely performed. in the era of extensive radical mastectomies, it was shown that up to 40% of breast cancer patients had nodal metastases in the internal mammary chain. this resulted in up to 10% of presumed "node-negative" patients actually being node-positive when the internal ...	2002	12175975
trichinella britovi in domestic pig--a case report.		2002	12173503