Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| transstadial effects of bti on traits of aedes aegypti and infection with dengue virus. | most mosquito control efforts are primarily focused on reducing the adult population size mediated by reductions in the larval population, which should lower risk of disease transmission. although the aim of larviciding is to reduce larval abundance and thus recruitment of adults, nonlethal effects on adults are possible, including transstadial effects on phenotypes of adults such as survival and pathogen infection and transmission. in addition, the mortality induced by control efforts may act i ... | 2016 | 26871951 |
| large-scale modelling of the environmentally-driven population dynamics of temperate aedes albopictus (skuse). | the asian tiger mosquito, aedes albopictus, is a highly invasive vector species. it is a proven vector of dengue and chikungunya viruses, with the potential to host a further 24 arboviruses. it has recently expanded its geographical range, threatening many countries in the middle east, mediterranean, europe and north america. here, we investigate the theoretical limitations of its range expansion by developing an environmentally-driven mathematical model of its population dynamics. we focus on t ... | 2016 | 26871447 |
| duplication and diversification of dipteran argonaute genes, and the evolutionary divergence of piwi and aubergine. | genetic studies of drosophila melanogaster have provided a paradigm for rna interference (rnai) in arthropods, in which the microrna and antiviral pathways are each mediated by a single argonaute (ago1 and ago2) and germline suppression of transposable elements is mediated by a trio of piwi-subfamily argonaute proteins (ago3, aub, and piwi). without a suitable evolutionary context, deviations from this can be interpreted as derived or idiosyncratic. here we analyze the evolution of argonaute gen ... | 2016 | 26868596 |
| screening for mosquito larvicidal activity of thai mushroom extracts with special reference to steccherinum sp against aedes aegypti (l.) (diptera: culicidae). | for over 50 years, biological control of mosquito larvae has depended mainly on plant extracts, fish, bacteria, protozoa, filamentous fungi, viruses or nematodes. in this study, we screened 143 mushroom samples from 44 confirmed species in thailand for their mosquito larvicidal activity. one g% (w/v) aqueous extracts of dried powdered mushroom samples were tested against 3rd stage aedes aegypti larvae. four mushroom species, namely, thaeogyroporus porentosus, xylaria nigripes, chlorophyllum sp a ... | 2015 | 26867377 |
| interim guidelines for prevention of sexual transmission of zika virus - united states, 2016. | zika virus is a mosquito-borne flavivirus primarily transmitted by aedes aegypti mosquitoes (1,2). infection with zika virus is asymptomatic in an estimated 80% of cases (2,3), and when zika virus does cause illness, symptoms are generally mild and self-limited. recent evidence suggests a possible association between maternal zika virus infection and adverse fetal outcomes, such as congenital microcephaly (4,5), as well as a possible association with guillain-barré syndrome. currently, no vaccin ... | 2016 | 26866485 |
| in silico analysis of an envelope domain iii-based multivalent fusion protein as a potential dengue vaccine candidate. | dengue virus infection is now a global problem. currently, there is no licensed vaccine or proven antiviral treatment against this virus. all four serotypes (1-4) of dengue virus can infect human. an effective dengue vaccine should be tetravalent to induce protective immune responses against all four serotypes. most of dengue vaccine candidates are monovalent, or in the form of physically mixed multivalent formulations. recently envelope protein domain iii of virus is considered as a vaccine can ... | 2016 | 26866023 |
| identification of essential containers for aedes larval breeding to control dengue in dhaka, bangladesh. | dengue fever (df), one of the most important emerging arboviral diseases, is transmitted through the bite of container breeding mosquitoes aedes aegypti and aedes albopictus. a household entomological survey was conducted in dhaka from august through october 2000 to inspect water-holding containers in indoor, outdoor, and rooftop locations for aedes larvae. the objective of this study was to determine mosquito productivity of each container type and to identify some risk factors of households in ... | 2015 | 26865829 |
| conservation, duplication, and divergence of five opsin genes in insect evolution. | opsin proteins covalently bind to small molecular chromophores and each protein-chromophore complex is sensitive to particular wavelengths of light. multiple opsins with different wavelength absorbance peaks are required for color vision. comparing opsin responses is challenging at low light levels, explaining why color vision is often lost in nocturnal species. here, we investigated opsin evolution in 27 phylogenetically diverse insect species including several transitions between photic niches ... | 2016 | 26865071 |
| absence of aedes aegypti (l.) on an ecological island: competitive exclusion? | ovitrap surveillance was conducted in 2012 and 2006 in malay and aboriginal villages on carey island. in each village, standard ovitraps were placed indoors and outdoors at randomly selected houses/locations. all l3 larvae recovered were identified up to species level. results demonstrated that only larvae of aedes albopictus were found in all the positive ovitraps placed indoors and outdoors. in 2012, a high ovitrap index (oi) of 66.7% indoor and 84.0% outdoor in the malay village; and 62.5% in ... | 2015 | 26863856 |
| climate and the timing of imported cases as determinants of the dengue outbreak in guangzhou, 2014: evidence from a mathematical model. | as the world's fastest spreading vector-borne disease, dengue was estimated to infect more than 390 million people in 2010, a 30-fold increase in the past half century. although considered to be a non-endemic country, mainland china had 55,114 reported dengue cases from 2005 to 2014, of which 47,056 occurred in 2014. furthermore, 94% of the indigenous cases in this time period were reported in guangdong province, 83% of which were in guangzhou city. in order to determine the possible determinant ... | 2016 | 26863623 |
| first report of y-linked genes in the kissing bug rhodnius prolixus. | due to an abundance of repetitive dna, the annotation of heterochromatic regions of the genome such as the y chromosome is problematic. the y chromosome is involved in key biological functions such as male-fertility and sex-determination and hence, accurate identification of its sequences is vital. the hemipteran insect rhodnius prolixus is an important vector of chagas disease, a trypanosomiasis affecting 6-7 million people worldwide. here we report the identification of the first y-linked gene ... | 2016 | 26861771 |
| multiple functions of na/k-atpase in dopamine-induced salivation of the blacklegged tick, ixodes scapularis. | control of salivary secretion in ticks involves autocrine dopamine activating two dopamine receptors: d1 and invertebrate-specific d1-like dopamine receptors. in this study, we investigated na/k-atpase as an important component of the secretory process. immunoreactivity for na/k-atpase revealed basal infolding of lamellate cells in type-i, abluminal interstitial (epithelial) cells in type-ii, and labyrinth-like infolding structures opening towards the lumen in type-iii acini. ouabain (10 μmol l( ... | 2016 | 26861075 |
| changes in the proteome of langat-infected ixodes scapularis ise6 cells: metabolic pathways associated with flavivirus infection. | ticks (family ixodidae) transmit a variety of disease causing agents to humans and animals. the tick-borne flaviviruses (tbfs; family flaviviridae) are a complex of viruses, many of which cause encephalitis and hemorrhagic fever, and represent global threats to human health and biosecurity. pathogenesis has been well studied in human and animal disease models. equivalent analyses of tick-flavivirus interactions are limited and represent an area of study that could reveal novel approaches for tbf ... | 2016 | 26859745 |
| a case report on oral subcutaneous dirofilariasis. | dirofilariasis is an uncommon zoonotic parasitic infection affecting human. the natural hosts for this nematode are animals such as dogs, cats, foxes, jackals, and raccoons. this disease is endemic in south eastern united states, australia, europe, and central and southern asia. dirofilaria immitis and d. repens are the common mosquito borne filarial nematodes that cause infection. several species of mosquitos including mansonia uniformis, m. annulifera, and aedes aegypti are the potential vecto ... | 2015 | 26858848 |
| toxic effect of blood feeding in male mosquitoes. | blood- and sugar feeding of female mosquitoes has been frequently observed in the laboratory and in the field, but only sugar feeding of males has been reported. here, we describe for the first time that culex quinquefasciatus males feed on blood as well. blood feeding easily happened on a blood-soaked cotton roll and, to a lesser extent, through a thin artificial layer. mating history of a male specimen does not affect his blood feeding behavior. male mosquitoes feed on blood even when they hav ... | 2016 | 26858651 |
| novel factors of anopheles gambiae haemocyte immune response to plasmodium berghei infection. | insect haemocytes mediate cellular immune responses (e.g., phagocytosis) and contribute to the synthesis of humoral immune factors. in previous work, a genome-wide molecular characterization of anopheles gambiae circulating haemocytes was followed by functional gene characterization using cell-based rnai screens. assays were carried out to investigate the role of selected haemocyte-specific or enriched genes in phagocytosis of bacterial bio-particles, expression of the antimicrobial peptide cecr ... | 2016 | 26858200 |
| the effect of temperature on wolbachia-mediated dengue virus blocking in aedes aegypti. | dengue fever, caused by dengue virus (denv), is endemic in more than 100 countries. the lack of effective treatment of patients and the suboptimal efficacies of the tetravalent vaccine in trials highlight the urgent need to develop alternative strategies to lessen the burden of dengue fever.wolbachia pipientis, an obligate intracellular bacterium, is being developed as a biocontrol strategy against dengue because it limits the replication of the denv in the mosquito vector,aedes aegypti however, ... | 2016 | 26856916 |
| the asian tiger hunts in maputo city--the first confirmed report of aedes (stegomyia) albopictus (skuse, 1895) in mozambique. | increasing evidence suggests that dengue fever is endemic in mozambique. larvae of both the afrotropical vector aedes aegypti and its subspecies, ae. aegypti formosus, have been reported from three provinces in mozambique, two of which recently experienced dengue outbreaks. despite reports of the invasive oriental vector ae. albopictus on the islands in the mozambique channel and nearby indian ocean, the species has not yet been reported in mozambique. | 2016 | 26856329 |
| genomic insights into the ixodes scapularis tick vector of lyme disease. | ticks transmit more pathogens to humans and animals than any other arthropod. we describe the 2.1 gbp nuclear genome of the tick, ixodes scapularis (say), which vectors pathogens that cause lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. the large genome reflects accumulation of repetitive dna, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. annotation of scaffolds representing ∼57% of the ge ... | 2016 | 26856261 |
| hexokinase is a key regulator of energy metabolism and ros activity in insect lifespan extension. | developmental arrest (diapause) is a 'non-aging' state that is similar to the caenorhabditis elegans dauer stage and drosophila lifespan extension. diapause results in low metabolic activity and a profound extension of insect lifespan. here, we cloned the helicoverpa armigera hexokinase (hk) gene, a gene that is critical for the developmental arrest of this species. hk expression and activity levels were significantly increased in nondiapause-destined pupae compared with those of diapause-destin ... | 0 | 26852422 |
| large-scale anopheles arabiensis egg quantification methods for mass-rearing operations. | the success of the sterile insect technique relies, among other things, on the continuous release of over flooding numbers of sexually competitive sterile males into the target area. to produce sufficiently large quantities of sterile males, rearing protocols need to be optimized including the development and validation of a standardized egg quantification method. | 2016 | 26852018 |
| [dengue and chikungunya vector control: is it necessary to re-examine present strategies?]. | 0 | 26849689 | |
| a comprehensive entomological, serological and molecular study of 2013 dengue outbreak of swat, khyber pakhtunkhwa, pakistan. | aedes aegypti and aedes albopictus play a fundamental role in transmission of dengue virus to humans. a single infected aedes mosquito is capable to act as a reservoir/amplifier host for dengue virus and may cause epidemics via horizontal and vertical modes of dengue virus (denv) transmission. the present and future dengue development can be clarified by understanding the elements which help the dissemination of dengue transmission. the current study deals with molecular surveillance of dengue i ... | 2016 | 26848847 |
| co-expression of dorsal and rel2 negatively regulates antimicrobial peptide expression in the tobacco hornworm manduca sexta. | nuclear factor κb (nf-κb) plays an essential role in regulation of innate immunity. in mammals, nf-κb factors can form homodimers and heterodimers to activate gene expression. in insects, three nf-κb factors, dorsal, dif and relish, have been identified to activate antimicrobial peptide (amp) gene expression. however, it is not clear whether dorsal (or dif) and relish can form heterodimers. here we report the identification and functional analysis of a dorsal homologue (msdorsal) and two relish ... | 2016 | 26847920 |
| the spermatophore in glossina morsitans morsitans: insights into male contributions to reproduction. | male seminal fluid proteins (sfps) transferred during copulation modulate female reproductive physiology and behavior, impacting sperm storage/use, ovulation, oviposition, and remating receptivity. these capabilities make them ideal targets for developing novel methods of insect disease vector control. little is known about the nature of sfps in the viviparous tsetse flies (diptera: glossinidae), vectors of human and animal african trypanosomiasis. in tsetse, male ejaculate is assembled into a c ... | 2016 | 26847001 |
| the hitchhiker's guide to europe: the infection dynamics of an ongoing wolbachia invasion and mitochondrial selective sweep in rhagoletis cerasi. | wolbachia is a maternally inherited and ubiquitous endosymbiont of insects. it can hijack host reproduction by manipulations such as cytoplasmic incompatibility (ci) to enhance vertical transmission. horizontal transmission of wolbachia can also result in the colonization of new mitochondrial lineages. in this study, we present a 15-year-long survey of wolbachia in the cherry fruit fly rhagoletis cerasi across europe and the spatiotemporal distribution of two prevalent strains, wcer1 and wcer2, ... | 2016 | 26846713 |
| a new allele conferring resistance to lysinibacillus sphaericus is detected in low frequency in culex quinquefasciatus field populations. | the cqm1 α-glucosidase of culex quinquefasciatus larvae acts as the midgut receptor for the binary toxin of the biolarvicide lysinibacillus sphaericus. mutations within the cqm1 gene can code for aberrant polypeptides that can no longer be properly expressed or bind to the toxin, leading to insect resistance. the cqm1 rec and cqm1 rec-2 alleles were identified in a laboratory selected colony and both displayed mutations that lead to equivalent phenotypes of refractoriness to l. sphaericus. cqm1 ... | 2016 | 26846600 |
| spatial variation of insecticide resistance in the dengue vector aedes aegypti presents unique vector control challenges. | dengue is a major public health problem in mexico, where the use of chemical insecticides to control the principal dengue vector, aedes aegypti, is widespread. resistance to insecticides has been reported in multiple sites, and the frequency of kdr mutations associated with pyrethroid resistance has increased rapidly in recent years. in the present study, we characterized patterns of insecticide resistance in ae. aegypti populations in five small towns surrounding the city of merida, mexico. | 2016 | 26846468 |
| differentiation of aedes aegypti and aedes notoscriptus (diptera: culicidae) eggs using scanning electron microscopy. | aedes notoscriptus and aedes aegypti are both peri-domestic, invasive container-breeding mosquitoes. while the two potential arboviral vectors are bionomically similar, their sympatric distribution in australia is limited. in this study, analyses of ae. aegypti and ae. notoscriptus eggs were enabled using scanning electron microscopy. significant variations in egg length to width ratio and outer chorionic cell field morphology between ae. aegypti and ae. notoscriptus enabled distinction of the t ... | 2016 | 26845557 |
| identification of male- and female-specific olfaction genes in antennae of the oriental fruit fly (bactrocera dorsalis). | the oriental fruit fly (bactrocera dorsalis) is a species of tephritid fruit fly, endemic to southeast asia but also introduced to many regions of the us, and it is one of the major pest species with a broad host range of cultivated and wild fruits. although males of b. dorsalis respond strongly to methyl eugenol and this is used for monitoring and estimating populations, the molecular mechanism of the oriental fruit fly olfaction has not been elucidated yet. therefore, in this project, using ne ... | 2016 | 26845547 |
| aedes aegypti anti-salivary gland antibody concentration and dengue virus exposure history in healthy individuals living in an endemic area in colombia. | mosquito salivary proteins are able to induce an antibody response that reflects the level of human-vector contact. igg antibodies against dengue virus (denv-igg) are indicators of previous exposure. the risk of denv transmission is not only associated to mosquito or dengue factors, but also to socioeconomic factors that may play an important role in the disease epidemiology. | 2016 | 26844447 |
| a method for assessing chemically-induced paralysis in headless mosquito larvae. | there is a growing interest in studies of mosquito physiology and toxicology due to the heightened need for controlling this group of human disease vectors. in the process of testing a group of polar compounds on mosquito muscles, a novel headless larva bioassay was developed. the heads were removed from fourth instar aedes aegypti larvae, which permitted access of pharmacological agents to the hemocoel while maintaining larval viability. the method allowed effective quantification of the paraly ... | 2014 | 26844208 |
| effects of food variability on growth and reproduction of aedes aegypti. | despite a large body of knowledge about the evolution of life histories, we know little about how variable food availability during an individual's development affects its life history. we measured the effects of manipulating food levels during early and late larval development of the mosquito aedes aegypti on its growth rate, life history and reproductive success. switching from low to high food led to compensatory growth: individuals grew more rapidly during late larval development and emerged ... | 2016 | 26843938 |
| inhibition of chikungunya virus replication by 1-[(2-methylbenzimidazol-1-yl) methyl]-2-oxo-indolin-3-ylidene] amino] thiourea(mbzm-n-ibt). | chikungunya virus (chikv) infection is one of the most challenging human arboviral infections with global significance and without any specific antiviral. in this investigation, 1-[(2-methylbenzimidazol-1-yl) methyl]-2-oxo-indolin-3-ylidene] amino] thiourea (mbzm-n-ibt) was synthesised as a molecular hybrid of 2-methyl benzimidazole and isatin-β-thiosemicarbazone and its anti-chikv property was evaluated. the release of infectious virus particles was calculated by plaque assay, expression profil ... | 2016 | 26843462 |
| human c5a protein participates in the mosquito immune response against dengue virus. | dengue virus (denv) is transmitted by aedes spp mosquitoes during a bloodmeal uptake. the bloodmeal consists of host cells, immune factors, and possibly blood-borne pathogens, such as arboviruses. human cells and immune-related factors, like the complement system, can remain active in the bloodmeal and may be able to interact with pathogens in the mosquito. previous studies have shown that active complement proteins impact plasmodium parasite viability in the anopheles midgut. thus, we investiga ... | 2016 | 26843451 |
| development of a novel-type transgenic cotton plant for control of cotton bollworm. | the transgenic bt cotton plant has been widely planted throughout the world for the control of cotton budworm helicoverpa armigera (hubner). however, a shift towards insect tolerance of bt cotton is now apparent. in this study, the gene encoding neuropeptide f (npf) was cloned from cotton budworm h. armigera, an important agricultural pest. the npf gene produces two splicing mrna variants-npf1 and npf2 (with a 120-bp segment inserted into the npf1 sequence). these are predicted to form the matur ... | 2016 | 26841044 |
| altered carbohydrates allocation by associated bacteria-fungi interactions in a bark beetle-microbe symbiosis. | insect-microbe interaction is a key area of research in multiplayer symbiosis, yet little is known about the role of microbe-microbe interactions in insect-microbe symbioses. the red turpentine beetle (rtb) has destroyed millions of healthy pines in china and forms context-dependent relationships with associated fungi. the adult-associated fungus leptographium procerum have played key roles in rtb colonization. however, common fungal associates (l. procerum and ophiostoma minus) with rtb larvae ... | 2016 | 26839264 |
| microrna profiling of the whitefly bemisia tabaci middle east-aisa minor i following the acquisition of tomato yellow leaf curl china virus. | the begomoviruses are the largest and most economically important group of plant viruses exclusively vectored by whitefly (bemisia tabaci) in a circulative, persistent manner. during this process, begomoviruses and whitefly vectors have developed close relationships and complex interactions. however, the molecular mechanisms underlying these interactions remain largely unknown, and the microrna profiles for viruliferous and nonviruliferous whiteflies have not been studied. | 2016 | 26837429 |
| unique features of a global human ectoparasite identified through sequencing of the bed bug genome. | the bed bug, cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. this global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. analyses of the c. lectularius sequenced genome (650 mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory ... | 2016 | 26836814 |
| developing antibodies from cholinesterase derived from prokaryotic expression and testing their feasibility for detecting immunogen content in daphnia magna. | to yield cholinesterase (che) from prokaryotic expression, the che gene that belongs to daphnia magna was amplified by reverse transcription-polymerase chain reaction (rt-pcr) using forward primer 5'-cccyggngcsat gatgtg-3' and reverse primer 5'-gyaagttrgcccaatatct-3'. to express the gene, one sequence of the amplified dna, which was able to encode a putative protein containing two conserved carboxylesterase domains, was connected to the prokaryotic expression vector pet-29a(+). the recombinant v ... | 0 | 26834012 |
| the role of the membrane in the structure and biophysical robustness of the dengue virion envelope. | the dengue virion is surrounded by an envelope of membrane proteins surrounding a lipid bilayer. we have combined the cryoelectron microscopy structures of the membrane proteins (pdb: 3j27) with a lipid bilayer whose composition is based on lipidomics data for insect cell membranes, to obtain a near-atomic resolution computational model of the envelope of the dengue virion. a coarse-grained molecular dynamics simulation on the microsecond timescale enables analysis of key biophysical properties ... | 2016 | 26833387 |
| assessing chikungunya risk in a metropolitan area of argentina through satellite images and mathematical models. | chikungunya fever is a viral disease that recently invaded the american continent. in america, it is transmitted mainly by the mosquito aedes aegypti, but aedes albopictus is the main vector in other regions of the world. this work estimates the risk of disease emergence and the corresponding population at risk for the case of a naive population in the metropolitan area of buenos aires, the capital city of argentina. | 2016 | 26830024 |
| serological and entomological study of dengue in dang and chitwan districts of nepal. | a descriptive cross-sectional study was carried out among 264 suspected dengue patients in two districts (dang and chitwan) of nepal from june 2013 to november 2013. the anti-dengue igm positivity was found to be (51/264)19.31% by capture elisa, of which 21 (41.2%) were male and 30 (58.8%) were female. symptoms of seropositive cases were fever, anorexia, nausea, headache, retro-orbital pain, skin rashes, and myalgia. hematological features like thrombocytopenia and leucopenia were found to be si ... | 2016 | 26828951 |
| aphicidal activity of illicium verum fruit extracts and their effects on the acetylcholinesterase and glutathione s-transferases activities in myzus persicae (hemiptera: aphididae). | this study aims to explore the aphicidal activity and underlying mechanism of illicium verum hook. f. that is used as both food and medicine. the contact toxicity of the extracts from i. verum fruit with methyl alcohol (ma), ethyl acetate (ea), and petroleum ether (pe) against myzus persicae (sulzer), and the activities of acetylcholinesterase (ache) and glutathione s-transferases (gsts) of m. persicae after contact treatment were tested. the results showed that ma, ea, and pe extracts of 1.000 ... | 2016 | 26826651 |
| accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a denv-4 epidemic. | early diagnosis of dengue infection is important for decision-making and timely implementation of therapeutic measures. although rapid ns1 assays have been used for dengue diagnosis since 2008, their performance in denv-4 cases has not yet been fully assessed. | 2016 | 26822788 |
| larvicidal potential of the halogenated sesquiterpene (+)-obtusol, isolated from the alga laurencia dendroidea j. agardh (ceramiales: rhodomelaceae), against the dengue vector mosquito aedes aegypti (linnaeus) (diptera: culicidae). | dengue is considered a serious public health problem in many tropical regions of the world including brazil. at the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, aedes aegypti linnaeus. in the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. in our work, we investigated the toxicity of a bioactive compound extracted from the red alga laure ... | 2016 | 26821032 |
| the iflaviruses sacbrood virus and deformed wing virus evoke different transcriptional responses in the honeybee which may facilitate their horizontal or vertical transmission. | sacbrood virus (sbv) and deformed wing virus (dwv) are evolutionarily related positive-strand rna viruses, members of the iflavirus group. they both infect the honeybee apis mellifera but have strikingly different levels of virulence when transmitted orally. honeybee larvae orally infected with sbv usually accumulate high levels of the virus, which halts larval development and causes insect death. in contrast, oral dwv infection at the larval stage usually causes asymptomatic infection with low ... | 2016 | 26819848 |
| correlation of clinicohaematological parameters in paediatric dengue: a retrospective study. | dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquito aedes aegypti. dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mortality. this was a retrospective study conducted in a tertiary care hospital in coastal karnataka, south india, to know the correlation between the clinical presentation and haematological parameters in the paediatric cases presented wit ... | 2015 | 26819620 |
| reference genes for accessing differential expression among developmental stages and analysis of differential expression of obp genes in anastrepha obliqua. | the west indian fruit fly, anastrepha obliqua, is an important agricultural pest in the new world. the use of pesticide-free methods to control invasive species such as this reinforces the search for genes potentially useful in their genetic control. therefore, the study of chemosensory proteins involved with a range of responses to the chemical environment will help not only on the understanding of the species biology but may also help the development of environmentally friendly pest control st ... | 2016 | 26818909 |
| cross-protection induced by japanese encephalitis vaccines against different genotypes of dengue viruses in mice. | dengue viruses (denvs) and japanese encephalitis virus (jev) are closely related mosquito-borne flaviviruses that cause very high global disease burdens. although cross-reactivity and cross-protection within flaviviruses have been demonstrated, the effect of jev vaccination on susceptibility to denv infection has not been well elucidated. in this study, we found that vaccination with the jev inactivated vaccine (inv) and live attenuated vaccine (lav) could induce cross-immune responses and cross ... | 2016 | 26818736 |
| mechanisms of sex determination and transmission ratio distortion in aedes aegypti. | more effective mosquito control strategies are urgently required due to the increasing prevalence of insecticide resistance. the sterile insect technique (sit) and the release of insects carrying a dominant lethal allele (ridl) are two proposed methods for environmentally-friendly, species-targeted population control. these methods may be more suitable for developing countries if producers reduce the cost of rearing insects. the cost of control programs could be reduced by producing all-male mos ... | 2016 | 26818000 |
| ligand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite varroa destructor. | the varroa mite, varroa destructor, is a devastating ectoparasite of the honey bees apis mellifera and a. cerana. control of these mites in beehives is a challenge in part due to the lack of toxic agents that are specific to mites and not to the host honey bee. in searching for a specific toxic target of varroa mites, we investigated two closely related neuropeptidergic systems, tachykinin-related peptide (trp) and natalisin (ntl), and their respective receptors. honey bees lack both ntl and the ... | 2016 | 26817786 |
| characterization of enzymatic profiles of aedes aegypti strains from the state of rio grande do norte, brazil. | this study was conducted in four strains of aedes aegypti mosquitoes to evaluate the enzymatic activity profiles in the city of mossoró, rio grande do norte, and correlate them with biochemical mechanisms of resistance to insecticides. mosquitos were used to quantify the following detoxification enzymes: mixed-function oxidase (mfo), pnpa-esterase (pnpa-est), and acetylcholinesterase (ache). the profiles were compared statistically with profiles from the rockefeller strain, through the kruskal-w ... | 2016 | 26816185 |
| the risk of dengue virus transmission in dar es salaam, tanzania during an epidemic period of 2014. | in 2010, 2012, 2013 and 2014 dengue outbreaks have been reported in dar es salaam, tanzania. however, there is no comprehensive data on the risk of transmission of dengue in the country. the objective of this study was to assess the risk of transmission of dengue in dar es salaam during the 2014 epidemic. | 2016 | 26812489 |
| accuracy of dengue reporting by national surveillance system, brazil. | 0 | 26812472 | |
| quantifying interspecific variation in dispersal ability of noctuid moths using an advanced tethered flight technique. | dispersal plays a crucial role in many aspects of species' life histories, yet is often difficult to measure directly. this is particularly true for many insects, especially nocturnal species (e.g. moths) that cannot be easily observed under natural field conditions. consequently, over the past five decades, laboratory tethered flight techniques have been developed as a means of measuring insect flight duration and speed. however, these previous designs have tended to focus on single species (ty ... | 2015 | 26811783 |
| comprehensive immunolocalization studies of a putative serotonin receptor from the alimentary canal of aedes aegypti larvae suggest its diverse roles in digestion and homeostasis. | serotonin regulates key processes including digestion and homeostasis in insects. serotonin effects are mediated by serotonin receptors that transduce information through initiation of second messenger signaling pathways. lack of information on serotonin receptors associated with the alimentary canal impedes the understanding of the serotonergic role in insect physiology. to address this void, the present study has cloned and identified a putative serotonin receptor (hereafter aaser-1) from the ... | 2016 | 26808995 |
| infection of mosquito cells (c6/36) by dengue-2 virus interferes with subsequent infection by yellow fever virus. | dengue is one of the most important diseases caused by arboviruses in the world. yellow fever is another arthropod-borne disease of great importance to public health that is endemic to tropical regions of africa and the americas. both yellow fever and dengue viruses are flaviviruses transmitted by aedes aegypti mosquitoes, and then, it is reasonable to consider that in a given moment, mosquito cells could be coinfected by both viruses. therefore, we decided to evaluate if sequential infections o ... | 2016 | 26808727 |
| the spread of dengue in an endemic urban milieu--the case of delhi, india. | dengue is a major international public health concern, one of the most important arthropod-borne diseases. more than 3.5 billion people are at risk of dengue infection and there are an estimated 390 million dengue infections annually. this prolific increase has been connected to societal changes such as population growth and increasing urbanization generating intense agglomeration leading to proliferation of synanthropic mosquito species. quantifying the spatio-temporal epidemiology of dengue in ... | 2016 | 26808518 |
| high prevalence of west nile virus in domestic birds and detection in 2 new mosquito species in madagascar. | west nile virus is an arthropod-borne zoonosis transmitted by a large number of mosquito species, and birds play a key role as reservoir of the virus. its distribution is largely widespread over africa, asia, the americas and europe. since 1978, it has frequently been reported in madagascar. studies described a high seroprevalence level of the virus in humans in different areas of the island and a human fatal case of wnv infection was reported in 2011. despite these reports, the epidemiology of ... | 2016 | 26807720 |
| towards plant species identification in complex samples: a bioinformatics pipeline for the identification of novel nuclear barcode candidates. | monitoring of the food chain to fight fraud and protect consumer health relies on the availability of methods to correctly identify the species present in samples, for which dna barcoding is a promising candidate. the nuclear genome is a rich potential source of barcode targets, but has been relatively unexploited until now. here, we show the development and use of a bioinformatics pipeline that processes available genome sequences to automatically screen large numbers of input candidates, ident ... | 2016 | 26807711 |
| whole-genome sequencing analysis from the chikungunya virus caribbean outbreak reveals novel evolutionary genomic elements. | chikungunya virus (chikv), an alphavirus and member of the togaviridae family, is capable of causing severe febrile disease in humans. in december of 2013 the asian lineage of chikv spread from the old world to the americas, spreading rapidly throughout the new world. given this new emergence in naïve populations we studied the viral genetic diversity present in infected individuals to understand how chikv may have evolved during this continuing outbreak. | 2016 | 26807575 |
| something "hairy" in juvenile hormone signaling for mosquito reproduction. | 2016 | 26802123 | |
| accurate transposable element annotation is vital when analyzing new genome assemblies. | transposable elements (tes) are mobile genetic elements with the ability to replicate themselves throughout the host genome. in some taxa tes reach copy numbers in hundreds of thousands and can occupy more than half of the genome. the increasing number of reference genomes from nonmodel species has begun to outpace efforts to identify and annotate te content and methods that are used vary significantly between projects. here, we demonstrate variation that arises in te annotations when less than ... | 2016 | 26802115 |
| genetic diversity and phylogeny of aedes aegypti, the main arbovirus vector in the pacific. | the pacific region is an area unique in the world, composed of thousands of islands with differing climates and environments. the spreading and establishment of the mosquito aedes aegypti in these islands might be linked to human migration. ae. aegypti is the major vector of arboviruses (dengue, chikungunya and zika viruses) in the region. the intense circulation of these viruses in the pacific during the last decade led to an increase of vector control measures by local health authorities. the ... | 2016 | 26799213 |
| serotonergic innervation of the salivary glands and central nervous system of adult glossina pallidipes austen (diptera: glossinidae), and the impact of the salivary gland hypertrophy virus (gpsghv) on the host. | using a serotonin antibody and confocal microscopy, this study reports for the first time direct serotonergic innervation of the muscle sheath covering the secretory region of the salivary glands of adult tsetse fly, glossina pallidipes austen. reports to date, however, note that up until this finding, dipteran species previously studied lack a muscle sheath covering of the secretory region of the salivary glands. direct innervation of the salivary gland muscle sheath of tsetse would facilitate ... | 2016 | 26798144 |
| insecticidal activity and insect repellency of four species of sea lily (comatulida: comatulidae) from taiwan. | the methanol and ethyl acetate (ea) extracts of four species of sea lily (himerometra magnipinna, comaster multifidus, comanthina sp., and comatella maculata) were evaluated for their insecticidal activity against yellow-fever mosquito larvae (aedes aegypti) and their repellency against adult asian tiger mosquitoes (aedes albopictus). the 24-hr minimum inhibition concentration (mic) data revealed that the extracts from h. magnipinna and the c. maculata were the most active, killing mosquito larv ... | 2016 | 26798137 |
| aedes aegypti (l.) in latin american and caribbean region: with growing evidence for vector adaptation to climate change? | within latin america and the caribbean region the impact of climate change has been associated with the effects of rainfall and temperature on seasonal outbreaks of dengue but few studies have been conducted on the impacts of climate on the behaviour and ecology of aedes aegypti mosquitoes.this study was conducted to examine the adaptive behaviours currently being employed by a. aegypti mosquitoes exposed to the force of climate change in lac countries. the literature on the association between ... | 2016 | 26796862 |
| effect of cymbopogon citratus (lemongrass) and syzygium aromaticum (clove) oils on the morphology and mortality of aedes aegypti and anopheles dirus larvae. | cymbopogon citratus (lemongrass) and syzygium aromaticum (clove) oils were evaluated to determine mortality rates, morphological aberrations, and persistence when used against third and fourth larval instars of aedes aegypti and anopheles dirus. the oils were evaluated at 1, 5, and 10 % concentrations in mixtures with soybean oil. persistence of higher concentrations was measured over a period of 10 days. for ae. aegypti, both plant oils caused various morphological aberrations to include deform ... | 2016 | 26796022 |
| mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo. | chikungunya virus (chikv) infection is a persistent problem worldwide due to efficient adaptation of the viral vectors, aedes aegypti and aedes albopictus mosquitoes. therefore, the absence of effective anti-chikv drugs to combat chikungunya outbreaks often leads to a significant impact on public health care. in this study, we investigated the antiviral activity of drugs that are used to alleviate infection symptoms, namely, the non-steroidal anti-inflammatory drugs (nsaids), on the premise that ... | 2016 | 26794398 |
| delivery of chitosan/dsrna nanoparticles for silencing of wing development vestigial (vg) gene in aedes aegypti mosquitoes. | rna interference (rnai) has been used as a gene silencing strategy by the introduction of long double stranded rna (dsrna) for the control of pest insects. the aim of the present study was to examine whether the expression of vg gene which is responsible for wing development, can be repressed by chitosan/dsrna based nanoparticles in aedes aegypti. the vestigial gene (vg) was amplified from adult mosquito and cloned in plitmus28i vector. genetically engineered recombinant plasmid was transformed ... | 2016 | 26794313 |
| identification of the temperature induced larvicidal efficacy of agave angustifolia against aedes, culex, and anopheles larvae. | synthetic insecticides are generally employed to control the mosquito population. however, their injudicious over usage and non-biodegradability are associated with many adverse effects on the environment and mosquitoes. the application of environment-friendly mosquitocidals might be an alternate to overcome these issues. in this study, we found that organic or aqueous extracts of agave angustifolia leaves exhibited a strong larvicidal activity (ld50 28.27 μg/ml) against aedes aegypti, culex qui ... | 2016 | 26793700 |
| the chikungunya epidemic: a look at five cases. | chikungunya is an infection caused by the chikungunya virus and transmitted by the bite of infected mosquito. the most common symptoms of chikungunya virus infection are fever, joint pain or rash. chikungunya virus outbreaks had been identified in countries in africa, asia, europe, and the indian and pacific oceans. in late 2013, the first local transmission of chikungunya virus in the americas was identified in caribbean countries and territories. chikungunya virus disease became a nationally n ... | 2015 | 26793467 |
| chikungunya fever: atypical and lethal cases in the western hemisphere: a venezuelan experience. | a large epidemic of chikungunya fever currently affects the caribbean, central and south america. despite a high number of reported cases, little is known on the occurrence of severe clinical complications. we describe four venezuelan patients with a severe and/or lethal course who exhibit unusual manifestations of the disease. case 1 describes a 75 year-old man with rapid onset of septic shock and multi-organ failure. cases 2 and 3 describe two patients with rapid aggressive clinical course who ... | 2014 | 26793440 |
| "the environment is everything that isn't me": molecular mechanisms and evolutionary dynamics of insect clocks in variable surroundings. | circadian rhythms are oscillations in behavior, metabolism and physiology that have a period close to 24 h. these rhythms are controlled by an internal pacemaker that evolved under strong selective pressures imposed by environmental cyclical changes, mainly of light and temperature. the molecular nature of the circadian pacemaker was extensively studied in a number of organisms under controlled laboratory conditions. but although these studies were fundamental to our understanding of the circadi ... | 2016 | 26793115 |
| a review of swertia chirayita (gentianaceae) as a traditional medicinal plant. | swertia chirayita (gentianaceae), a popular medicinal herb indigenous to the temperate himalayas is used in traditional medicine to treat numerous ailments such as liver disorders, malaria, and diabetes and are reported to have a wide spectrum of pharmacological properties. its medicinal usage is well-documented in indian pharmaceutical codex, the british, and the american pharmacopeias and in different traditional medicine such as the ayurveda, unani, siddha, and other conventional medical syst ... | 2015 | 26793105 |
| larvicidal and repellent potential of zingiber nimmonii (j. graham) dalzell (zingiberaceae) essential oil: an eco-friendly tool against malaria, dengue, and lymphatic filariasis mosquito vectors? | mosquitoes (diptera: culicidae) are important vectors of terms of public health relevance, especially in tropical and sub-tropical regions. the continuous and indiscriminate use of conventional pesticides for the control of mosquito vectors has resulted in the development of resistance and negative impacts on non-target organisms and the environment. therefore, there is a need for development of effective mosquito control tools. in this study, the larvicidal and repellent activity of zingiber ni ... | 2016 | 26792432 |
| combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an improved mosquito landing box. | on-going malaria transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (llins) are widespread. often, the vectors are also physiologically resistant to insecticides, presenting major obstacles for elimination. we tested a combination of electrocuting grids with synthetic odours as an alternative killing mechanism against outdoor-biting mosquitoes. | 2016 | 26789733 |
| mayaro virus and dengue virus 1 and 4 natural infection in culicids from cuiabá, state of mato grosso, brazil. | this study aimed to verify the diversity of culicidae species and their frequency of infection with flaviviruses and alphaviruses in cuiabá, state of mato grosso, brazil. mosquitoes were captured with nasci aspirators and hand net in 200 census tracts, identified alive at species level and pooled in one-20 (11,090 mosquitoes, 14 species). female pools (n = 610) were subjected to multiplex seminested-reverse transcription-polymerase chain reaction (rt-pcr) for 11 flavivirus and five alphavirus. p ... | 0 | 26784852 |
| apoptosis, autophagy and unfolded protein response pathways in arbovirus replication and pathogenesis. | arboviruses are pathogens that widely affect the health of people in different communities around the world. recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. the arbovirus infection and replication processes are complex, and many factors are involved in their regulation. apoptosis, autophagy and the unfolded protein r ... | 2016 | 26781343 |
| natural transmission of dengue virus serotype 3 by aedes albopictus (skuse) during an outbreak in havelock island: entomological characteristics. | from may to june 2014, an outbreak of dengue virus (denv) illness occurred in the havelock island, south andaman. entomological investigations were undertaken during the peak of the outbreak, from 26th may-4th june, to identify the primary vector(s) involved in the transmission so that appropriate public health measures could be implemented. adult mosquitoes were collected by bg-sentinel traps in houses and neighborhoods of clinically ill patients. water holding containers were inspected for the ... | 2016 | 26780552 |
| anticipating the international spread of zika virus from brazil. | 2016 | 26777915 | |
| exploiting intimate relationships: controlling mosquito-transmitted disease with wolbachia. | mosquito-transmitted diseases impose a growing burden on human health, and current control strategies have proven insufficient to stem the tide. the bacterium wolbachia is a novel and promising form of control for mosquito-transmitted disease. it manipulates host biology, restricts infection with dengue and other pathogens, and alters host reproduction to promote rapid spread in the field. in this review, we examine how the intimate and diverse relationships formed between wolbachia and their mo ... | 2016 | 26776329 |
| autophagy and viral diseases transmitted by aedes aegypti and aedes albopictus. | despite a long battle that was started by oswaldo cruz more than a century ago, in 1903, brazil still struggles to fight aedes aegypti and aedes albopictus, the mosquito vectors of dengue virus (denv), chikungynya virus (chikv) and zika virus (zikv). dengue fever has been a serious public health problem in brazil for decades, with recurrent epidemic outbreaks occurring during summers. in 2015, until november, 1,534,932 possible cases were reported to the ministry of healthv. more recently, the l ... | 2016 | 26774331 |
| calcium influx enhances neuropeptide activation of ecdysteroid hormone production by mosquito ovaries. | a critical step in mosquito reproduction is the ingestion of a blood meal from a vertebrate host. in mosquitoes like aedes aegypti, blood feeding stimulates the release of ovary ecdysteroidogenic hormone (oeh) and insulin-like peptide 3 (ilp3). this induces the ovaries to produce ecdysteroid hormone (ecd), which then drives egg maturation. in many immature insects, prothoracicotropic hormone (ptth) stimulates the prothoracic glands to produce ecd that directs molting and metamorphosis. the recep ... | 2016 | 26772671 |
| population genetic structure and potential incursion pathways of the bluetongue virus vector culicoides brevitarsis (diptera: ceratopogonidae) in australia. | culicoides brevitarsis is a vector of the bluetongue virus (btv), which infects sheep and cattle. it is an invasive species in australia with an assumed asian/south east asian origin. using one mitochondrial marker (i.e., part of the cytochrome oxidase subunit i gene) and six nuclear markers, we inferred population genetic structure and possible incursion pathways for australian c. brevitarsis. nine mitochondrial haplotypes, with low nucleotide sequence diversity (0.0-0.7%) among these, were ide ... | 2016 | 26771743 |
| [effect of bacillus thuringiensis var. israelensis (bti) on detoxification enzyme activity of larvae of culex pipiens pallens and aedes aegypti]. | to investigate the effect of bacillus thuringiensis var. israelensis (bti) on the activities of three detoxification enzymes of culex pipiens pallens and aedes aegypti larvae. | 2015 | 26767261 |
| the prevention and control of dengue after typhoon haiyan. | many of the areas in the philippines affected by typhoon haiyan are endemic for dengue; therefore, dengue prevention was a priority in the initial post-disaster risk assessment. we describe the dengue prevention and response strategies applied after haiyan. | 2015 | 26767138 |
| trends in dengue cases imported into the united states from pan america 2001-2012. | the objective of this study was to improve risk assessments of travel on dengue (den) virus (denv) distribution. we investigated the exposure risk of us citizens traveling to den-endemic pan american countries. the number of den cases reported in 51 pan american countries from 2001 to 2012 was compared to the population of the same countries. the number of us travelers visiting the pan american countries was categorized by region, and travel-related den infections were analyzed. us residents vis ... | 2015 | 26766913 |
| genes and odors underlying the recent evolution of mosquito preference for humans. | mosquito species that specialize in biting humans are few but dangerous. they include the african malaria vectors anopheles gambiae and anopheles coluzzii, as well as aedes aegypti, the cosmopolitan vector of dengue, chikungunya, and yellow fever. these mosquitoes have evolved a remarkable innate preference for human odor that helps them find and bite us. here i review what is known about this important evolutionary adaptation, from its historical documentation to its chemical and molecular basi ... | 0 | 26766234 |
| comparison of irradiation and wolbachia based approaches for sterile-male strategies targeting aedes albopictus. | the global expansion of aedes albopictus together with the absence of vaccines for most of the arboviruses transmitted by this mosquito has stimulated the development of sterile-male strategies aiming at controlling disease transmission through the suppression of natural vector populations. in this context, two environmentally friendly control strategies, namely the sterile insect technique (sit) and the wolbachia-based incompatible insect technique (iit) are currently being developed in several ... | 2016 | 26765951 |
| caste-specific and sex-specific expression of chemoreceptor genes in a termite. | the sophisticated colony organization of eusocial insects is primarily maintained through the utilization of pheromones. the regulation of these complex social interactions requires intricate chemoreception systems. the recent publication of the genome of zootermopsis nevadensis opened a new avenue to study molecular basis of termite caste systems. although there has been a growing interest in the termite chemoreception system that regulates their sophisticated caste system, the relationship bet ... | 2016 | 26760975 |
| long-lasting immune protection and other epidemiological findings after chikungunya emergence in a cambodian rural community, april 2012. | the east/central/south african genotype of chikungunya virus with the e1-a226v mutation emerged in 2011 in cambodia and spread in 2012. an outbreak of 190 cases was documented in trapeang roka, a rural village. we surveyed 425 village residents within 3-4 weeks after the outbreak, and determined the sensitivity and specificity of case definitions and factors associated with infection by chikv. self-reported clinical presentation consisted mostly of fever, rash and arthralgia. the presence of all ... | 2016 | 26752630 |
| insecticide resistance and management strategies in urban ecosystems. | the increased urbanization of a growing global population makes imperative the development of sustainable integrated pest management (ipm) strategies for urban pest control. this emphasizes pests that are closely associated with the health and wellbeing of humans and domesticated animals. concurrently there are regulatory requirements enforced to minimize inadvertent exposures to insecticides in the urban environment. development of insecticide resistance management (irm) strategies in urban eco ... | 2016 | 26751480 |
| use of a probabilistic motif search to identify histidine phosphotransfer domain-containing proteins. | the wealth of newly obtained proteomic information affords researchers the possibility of searching for proteins of a given structure or function. here we describe a general method for the detection of a protein domain of interest in any species for which a complete proteome exists. in particular, we apply this approach to identify histidine phosphotransfer (hpt) domain-containing proteins across a range of eukaryotic species. from the sequences of known hpt domains, we created an amino acid occ ... | 2016 | 26751210 |
| carbon dioxide receptor genes and their expression profile in diabrotica virgifera virgifera. | diabrotica virgifera virgifera, western corn rootworm, is one of the most devastating species in north america. d. v. virgifera neonates crawl through the soil to locate the roots on which they feed. carbon dioxide (co2) is one of the important volatile cues that attract d. v. virgifera larvae to roots. | 2016 | 26746870 |
| protection of dogs against canine heartworm infection 28 days after four monthly treatments with advantage multi® for dogs. | monthly heartworm preventives are designed to protect dogs by killing heartworms acquired the month prior to their administration, and after treatment with most products, the drug levels rapidly dissipate to very low levels. work with advantage multi® for dogs (imidacloprid + moxidectin) topical solution showed protection against hookworm infection throughout the month after administration of several monthly doses suggesting that similar protection might occur with heartworms. this study assesse ... | 2016 | 26746229 |
| costs of three wolbachia infections on the survival of aedes aegypti larvae under starvation conditions. | the mosquito aedes aegypti, the principal vector of dengue virus, has recently been infected experimentally with wolbachia: intracellular bacteria that possess potential as dengue biological control agents. wolbachia depend on their hosts for nutrients they are unable to synthesize themselves. consequently, competition between wolbachia and their host for resources could reduce host fitness under the competitive conditions commonly experienced by larvae of ae. aegypti in the field, hampering the ... | 2016 | 26745630 |
| effects of bmcpv infection on silkworm bombyx mori intestinal bacteria. | the gut microbiota has a crucial role in the growth, development and environmental adaptation in the host insect. the objective of our work was to investigate the microbiota of the healthy silkworm bombyx mori gut and changes after the infection of b. mori cypovirus (bmcpv). intestinal contents of the infected and healthy larvae of b. mori of fifth instar were collected at 24, 72 and 144 h post infection with bmcpv. the gut bacteria were analyzed by pyrosequencing of the 16s rrna gene. 147(135) ... | 2016 | 26745627 |
| hairy and groucho mediate the action of juvenile hormone receptor methoprene-tolerant in gene repression. | the arthropod-specific juvenile hormone (jh) controls numerous essential functions. its involvement in gene activation is known to be mediated by the transcription factor methoprene-tolerant (met), which turns on jh-controlled genes by directly binding to e-box-like motifs in their regulatory regions. however, it remains unclear how jh represses genes. we used the aedes aegypti female mosquito, in which jh is necessary for reproductive maturation, to show that a repressor, hairy, is required for ... | 2016 | 26744312 |