Publications

activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases.	activation of the hageman factor-kallikrein-kinin system by serratial 56-kda proteinase was previously demonstrated (matsumoto, k., yamamoto, t., kamata, t., and maeda, h. (1984) j. biochem. (tokyo) 96, 739-749; kamata, r., yamamoto, t., matsumoto, k., and maeda, h. (1985) infect. immun. 48, 747-753). to investigate whether the activation of the system is specific for 56-kda proteinase or is found similarly with other microbial proteinases, 11 proteinases of microbial origins were studied; the 5 ...	1989	2499581
percutaneous fine needle aspiration biopsy using a modified coaxial technique.	a modified coaxial technique for the biopsy of small or deeply situated lesions using computed tomographic (ct) guidance is described. a 22-gauge needle was passed coaxially through an outer 18-gauge introducing needle and aspiration biopsy was performed. this modified coaxial technique allows for multiple biopsies to be obtained safely, expeditiously, and repeatedly.	2008	2496928
ovarian suppression induced with buserelin or danazol in the management of endometriosis: a randomized, comparative study.	the effectiveness of buserelin (hoechst-roussel pharmaceuticals, inc., somerville, nj) (0.2 mg subcutaneously [sc] or 1.2 mg intranasally [in] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. during 6 months of treatment, peripheral follicle-stimulating hormone (fsh), luteinizing hormone (lh), and estradiol concentrations were suppressed to a similar degree in both groups. symptomatic improve ...	2008	2493400
use of indium-111 as a red cell label.	to select the most promising 111in chelate for use as a second red cell (rbc) label for comparison of the survival of autologous and allogeneic cells, 49 normal rbc samples were studied in vitro after being labeled with 111in-8-hydroxyquinolinol (111in-oxine) prepared by three different methods, 111in-tropolone, and 111in-acetylacetone. labeling efficiencies reached 99 percent and did not decline when the amount of 111in used was increased from 1.75 to 50 muci per ml of rbcs. storage of labeled ...	2008	2493173
hemocyte monophenol oxidase activity in mosquitoes exposed to microfilariae of dirofilaria immitis.	monophenol oxidase (mpo) activity in hemocytes collected from aedes aegypti liverpool strain and aedes trivittatus intrathoracically inoculated with saline alone, inoculated with dirofilaria immitis microfilariae (mff), or from uninoculated mosquitoes was compared using a radiometric tyrosine hydroxylation assay. hemocyte mpo activity in mff-inoculated (= immune-activated) mosquitoes was significantly increased at 24 hr postinoculation (pi) in a. aegypti and at 6, 12, and 24 hr pi in a. trivitta ...	1989	2493084
unproven methods of cancer management. international association of cancer victors and friends, inc.	after study of the literature and other available information, the american cancer society has found no evidence that methods of treatment promoted by the international association of cancer victors and friends, inc. (iacvf), would result in objective benefit in the treatment of cancer in human beings. lacking such evidence, the american cancer society strongly urges individuals with cancer not to seek treatment based on the recommendations of iacvf.	1989	2492878
immunocytochemical study of localization and traffic of thyroid peroxidase/microsomal antigen.	we studied the distribution of binding sites for anti-peroxidase monoclonal antibody and anti-microsomal antibodies on isolated human thyroid follicles and a human thyroid cell line. both open follicles and cells were incubated first with antibodies at +4 degrees c, then with colloidal gold labelled protein a. the topography of the binding sites for monoclonal anti-peroxidase antibody corresponded closely to the expected cell surface distribution of endogenous thyroid peroxidase since labelling ...	1989	2491623
[nosocomial infection at a regional hospital].		2008	2490734
hemochromatosis and infection: alcohol and iron, oysters and sepsis.	hemochromatosis, or primary iron overload, is a variably expressed genetic metabolic disorder greatly modified by sex, age, diet, and alcohol consumption. although a diagnosis has been made at the bedside by careful documentation of the slow resolution of subcutaneous iron pigment, clinical diagnosis is frequently overlooked, and even autopsy may fail to reveal hemochromatosis as the cause for cirrhosis. genetic linkage studies have confirmed the extremely high prevalence of this disorder. untre ...	1989	2486533
sugar composition of the polysaccharide portion of lipopolysaccharides of vibrio fluvialis, vibrio vulnificus, and vibrio mimicus.	a chemotaxonomic study was carried out on vibrio fluvialis and v. vulnificus on the basis of the sugar composition of the polysaccharide portion of their lipopolysaccharides (lps). a previously developed rapid method of preparing samples for compositional sugar analysis was employed. nineteen o-serogroups of v. fluvialis were divided into 14 chemotypes while seven o-serogroups of v. vulnifucus were divided also into seven chemotypes since the polysaccharide portion of lps of each serogroup has a ...	1989	2482433
differential immunohistochemical localization of cytokeratins and collagen types i and iii in experimentally-induced cirrhosis.	liver cirrhosis was induced in male wistar rats by subcutaneous injection (1 ml of 30 g/l) of an aqueous solution of thioacetamide. using the indirect immunoperoxidase technique, high molecular weight keratins were localized in bile ducts and ductules. low molecular weight cytokeratins were present in regenerating hepatocytes in active cirrhosis; bile ducts were unstained. these results suggest that cytokeratin staining may be useful in distinguishing bile duct epithelium and hepatocytes in hepa ...	1989	2478687
inhibitory effect of alpha 2-macroglobulin on vibrio vulnificus protease.	vibrio vulnificus, an etiologic agent of wound infections and septicemia in humans, elaborates a metalloprotease which is known to be an important virulence factor of the vibrio. the proteolytic activity of v. vulnificus metalloprotease (vvp) toward casein and elastin was inhibited by alpha 2-macroglobulin (alpha 2 m) at the molar ratio of 1:1, although partial activity was maintained. permeability-enhancing and hemorrhagic activities were also inhibited, but the peptidase activity toward z-gly- ...	1989	2478526
[therapy monitoring of regional chemotherapy by magnetic resonance spectroscopy].		2008	2474953
aging and compartmentalization of the mucosal immune system.		2008	2447761
new differentiation antigens associated with the growth and maturation of b lymphocytes.	monoclonal antibodies (mab) nda3 and nda4 were generated by hyperimmunizing mice with an alloreactive human t cell clone and fusing the splenocytes with the ns1 myeloma. immunofluorescence studies indicated that these mab react with activated, but not with resting t and b lymphocytes or with other types of cells. immunoprecipitation studies with 125-i-labeled extracts from t and b cell lines demonstrated that the m.w. of the antigen recognized by mab nda3 is 36,000 and that of nda4 is 46,000. st ...	1988	2447175
use of endoscopic laser in gastroenterology.	in this presentation we report the current use of endoscopic laser in gastroenterology in japan with the results of a nation-wide survey and our own experience with more than 100 cases. nd:yag laser (photocoagulative therapy) and argon dye laser with hematoporphyrin derivative (photodynamic therapy) were most commonly used in digestive endoscopy, and were investigated as new modalities of cancer therapy and detection. by november 1985, 1588 of gastrointestinal (gi) cancers had been treated in ja ...	2008	2446562
influence of neuropeptides on airway smooth muscle.	the first bronchoactive (and vasoactive) peptide to be discovered in the lung was isolated and characterized in 1970 from an embryologically related organ, the small intestine. since then, more than 20 additional peptides have been described in lung tissue and their biologic activities investigated. many of these are neuropeptides acting as neurotransmitters or neuromodulators to influence airway, pulmonary vascular, and other functions. more neuropeptides are known to exist in the brain and per ...	1987	2446543
evolution and development of the outer acrosomal membrane (oam) and evidence that acrosin-inhibitors are proteins of the oam.	an antiserum to the purified porcine outer acrosomal membrane (oam) was raised in rabbits and the igg fraction isolated by ammonium sulphate precipitation and ion exchange chromatography. the antibodies reacted exclusively with the acrosomal cap of the sperm head as revealed by indirect immunofluorescence. in addition they cross-reacted not only with the acrosomal part of the spermatozoa of all mammalian species tested (bull, horse, rabbit, rat, mouse, hamster, mole, antelope, monkey, man) but a ...	1987	2446533
application of automated on-line microbore high-performance liquid chromatography/capillary gas chromatography to diesel exhaust particulates.		2008	2446529
improved synthesis and iodination of a cleavable photoactivated probe.	j. b. denny and g. blobel (1984, proc, natl. acad. sci. usa 81, 5286-5290) have described the synthesis of a water-soluble novel heterobifunctional 125i-labeled photocrosslinking reagent, n-[4-(p-azido-m-[125i]iodophenylazo)benzoyl]-3-aminopropionyl-n'- oxysulfosuccinimide, which contains a cleavable internal azo bond. we report several modifications of their synthesis which greatly increase the yield of a synthetic intermediate, n-[4-(p-aminophenylazo)benzoyl]-3-aminopropionic acid (compound vi ...	2008	2446528
cystic neoplasms of the pancreas.	eight patients with cystic neoplasms of the pancreas were seen at four northern california hospitals between the years 1978 and 1986. three of the tumors were benign and five were malignant. three females, whose average age was 61 years, had cystadenomas. three females and two males, whose average age was 48 years, had mucinous cystadenocarcinomas. clinical presentations were similar among all patients. abdominal pain was a prominent feature. anorexia, weight loss, nausea and vomiting with a pal ...	2008	2446398
protocol for rapid chemical rna sequencing.		2008	2443900
[intermittent intra-arterial infusion chemotherapy of intrapelvic malignancy].		2008	2443898
hybridocytochemistry with non-radioactive probes as a tool for biomedical research and cytodiagnostics.	the advent of dna and rna labelling techniques which allow non-autoradiographic detection of specific nucleic acid sequences has opened new possibilities for rapid diagnosis at the nucleic acid level. there are already practical applications. however, in order to fully compete with radioactive procedures an increase in sensitivity is still desired.	2007	2435580
the presence of the 30 nm filament structure of chromatins in intact chicken erythrocytes observed by 31p nmr.	a 31p nmr spectrum of chicken erythrocyte chromatins in vivo was obtained. the spectrum was characterized by examining the spectra of isolated nuclei and nondigested chromatins under various conditions. the results have shown that most chromatins in chicken erythrocyte nuclei assume the 30 nm filament structure as a second step of condensation of dna in vivo.	1987	2435577
correlation between virulence and colony morphology in vibrio vulnificus.	of 38 isolates of vibrio vulnificus examined, all avirulent strains produced only translucent colonies. all virulent strains, with the exception of biogroup 2 (eel pathogens), exhibited both opaque and translucent colonies. isogenic morphotypes were examined for a variety of phenotypic and virulence traits. only the ability to utilize transferrin-bound iron and the presence of a surface polysaccharide were found to correlate with colony opacity and virulence.	1987	2432016
[effects of enzymatic deglycosylation of human goiter thyroglobulin on its immunochemical properties].	thyroglobulin (tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial ria. carbohydrate and iodine content was chemically determined. by paage deglycosylated tg (dtg) showed the appearance of a major band in the 12s region and three slower migrating bands corresponding to higher aggregates than 19s tg. in immunodiffusion by testing native an ...	1986	2430684
identification and characterization of the nmyc gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities.	increased n-myc (now designated nmyc in human gene nomenclature) gene expression has been detected at the transcriptional level in certain types of neoplasms. as yet, the n-myc gene product has not been identified. to detect and characterize the n-myc gene product, we have developed monoclonal antibodies against the putative n-myc gene product made in escherichia coli as a fusion protein. the antibodies that recognize the n-myc-specific regions were selected on the basis of their reactivities to ...	1986	2426708
serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. comparison in chronic schizophrenic patients with suicide as cause of death.	serotonin (5-ht) and 5-hydroxyindoleacetic acid concentrations were determined in various brain areas of nonschizophrenic suicide victims, chronic schizophrenic patients with or without suicide as the cause of death, and normal control subjects without psychiatric or neurologic disorders. serotonin concentrations in the basal ganglia were significantly elevated in suicide victims and chronic schizophrenic patients, as were 5-hydroxyindoleacetic acid concentrations in the occipital cortex. these ...	1986	2423050
a study on the pharmacokinetics in mouse of adenine-9-beta-d-arabinofuranoside 5-monophosphate conjugated with lactosaminated albumin.	in plasma of mice injected with adenine-9-beta-d-arabinofuranoside monophosphate (ara-amp) coupled to human lactosaminated serum albumin (l-hsa) some of the ara-amp molecules are enzymatically released, whereas others remain linked to l-hsa. evidence has been obtained that ara-amp is not deaminated when it is conjugated to l-hsa, in contrast to the free drug which is rapidly metabolized to its hypoxanthine derivative.	1985	2412878
catalase enhances damage to dna by bleomycin-iron(ii): the role of hydroxyl radicals.	bleomycin degrades dna under aerobic conditions when a ferrous salt is added. this reaction is enhanced by catalase and certain hydroxyl radical scavengers but inhibited by the addition of hydrogen peroxide. a ferricbleomycin complex is, however, stimulated by addition of hydrogen peroxide. these findings suggest that catalase removes hydrogen peroxide and in so doing prevents loss of ferrous ions and formation of hydroxyl radicals (oh.) by a fenton-type reaction. it further suggests that oh. ra ...	1985	2409975
metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse.	we have studied the fate of radiometal metabolism in vivo by analyzing the molecular form of radiolabeled anti-carcinoembryonic antigen (cea) in tissues. athymic mice bearing colonic tumor xenografts were injected i.v. with 111in-isothiocyanate-benzyl-dtpa-(scn-bz-dtpa) igg or 111in-(scn-bz-dtpa) f(ab')2, and then killed daily for up to four days. liver, kidney, and tumor were extracted and the supernatants, plasma and urine samples were analyzed by hplc, itlc, hpiec and sds-page. by hplc, the a ...	1990	2395019
are separable aromatase systems involved in hormonal regulation of the male brain?	in vitro study of testosterone (t) metabolism shows that formation of estradiol-17 beta (e2) is regionally specific within the preoptic area (poa) of the male ring dove. the poa is known to be involved in the formation of e2 required for specific components of male sexual behavior. two sub-areas of high aromatase activity, anterior (apoa) and posterior preoptic (ppoa) areas, have been identified. aromatase activity is higher in apoa than in ppoa. the aromatase activity within the apoa is also mo ...	1990	2394989
increase in carcinoembryonic antigen release from cancer cells by combined treatment with retinoic acid and low-temperature hyperthermia.	the growth of a human gastric adenocarcinoma cell line, mkn-45, was inhibited and the amount of carcinoembryonic antigen (cea) in both the culture medium and the cell extract was increased in the presence of retinoic acid at a concentration of 75 (1.5x)-125 microm (1.9x), which did not substantially affect cell survival. treatment using a combination of retinoic acid (125 microm) and low-temperature hyperthermia (40 degrees c, 30 min) was more effective in increasing cea compared with retinoic a ...	1990	2394926
[prostheses on osteointegrated implants: restoration of a missing tooth (4)].	this article is the last of a series of four. this article describes in detail the fabrication of a crown connected to a brånemark implant.	2008	2394869
white noise analysis of temporal properties in simple receptive fields of cat cortex.	we studied the linear and nonlinear temporal response properties of simple cells in cat visual cortex by presenting at single positions in the receptive field an optimally oriented bar stimulus whose luminance was modulated in a random, binary fashion. by crosscorrelating a cell's response with the input it was possible to obtain the zeroth-, first-, and second-order wiener kernels at each rf location. simple cells showed pronounced nonlinear temporal properties as revealed by the presence of pr ...	1990	2390534
vibrio bacteremia in siriraj hospital.	from january 1983 to march 1988, 26 isolates of vibrio spp. were recovered from the blood of patients admitted to siriraj hospital. thirteen strains were identified as non 0-1 vibrio cholerae, 3 were vibrio vulnificus and 10 were vibrio spp. the medical records of 20 patients were available for clinical analysis. most of them were adult men with cirrhosis. clinical features included fever, abdominal pain, diarrhea, peritonitis, shock and skin lesions. some patients had a history of seafood consu ...	1990	2380645
contingent negative variation and reaction time of physically-trained subjects in simple and discriminative tasks.	contingent negative variations (cnv) were recorded during the s1-s2 interval of two simple and one discriminative task at fz, cz and pz of 12 physically-trained college athletes and 12 non-trained students. the reaction time to s2 was also measured. the whole mean cnv amplitude average over the 2 sec s1-s2 interval and the segmented cnv amplitudes of the 250 msec epochs were submitted to 4-way anova (physical training x task x electrode position x gender), while the mean reaction time was analyz ...	1995	2376531
the cytolysin gene of vibrio vulnificus: sequence and relationship to the vibrio cholerae e1 tor hemolysin gene.	a cytolysin of ca. 56 kilodaltons has been suggested as a possible virulence factor in vibrio vulnificus infections. we sequenced the dna encoding cytolytic activity and found that the sequence contained two open reading frames, vvha and vvhb. vvha encoded the structural gene for the cytolysin and contained the n-terminal amino acid sequence previously reported for the protein. regions of the vvha gene showed homology to the structural gene for the vibrio cholerae e1 tor hemolysin.	1990	2370116
blockade of inhibition in a pathway with dual excitatory and inhibitory action unmasks a capability for ltp that is otherwise not expressed.	long-term potentiation (ltp) can be readily elicited in a number of hippocampal pathways, but has not been seen in the dentate commissural pathway. the dentate commissural pathway is similar to the commissural/schaffer collateral projection to ca1 except that it produces powerful inhibition that occurs nearly concurrently with the excitation. the present study evaluates whether this inhibition prevents the pathway from expressing ltp. acute neurophysiological experiments were carried out in uret ...	1990	2364294
pathogenesis of minimal change nephropathy.		2008	2362129
casein and casein subunits in preterm milk, colostrum, and mature human milk.	human milk proteins have both nutritional and physiological roles for the breast-fed infant. while the biochemistry and developmental patterns for many whey proteins are well known, our knowledge of human casein and its subunits is still limited. we have recently developed a method to isolate casein from whey proteins in human milk and to separate the casein subunits by fast protein liquid chromatography. in this study we have applied this methodology to study the casein subunit pattern in prete ...	1990	2358977
[neoplasms of the meckel diverticulum. apropos of 2 new cases].	we present two new cases of cancer in a meckel's diverticulum, representing 3.3% of the complicated meckel's diverticula encountered in our department. the first case was a carcinoid tumor encountered in a pathology study of an inflamed meckel's diverticulum, and the second case was a leiomyosarcoma on a meckel's diverticulum that presented as diverticular perforation. we emphasize the advanced age of the two patients and review the cases reported in spain and in the western literature.	2008	2346684
contempo '90.		2008	2329645
phytochrome from the green alga mesotaenium caldariorum. purification and preliminary characterization.	a method to purify the phytochrome photoreceptor from the unicellular green alga mesotaenium caldariorum is presented. preparative scale formation of algal protoplasts and controlled osmotic cell lysis have permitted separation of intact organelles from the phytochrome-enriched soluble protein fraction. we have utilized the observation that red light-absorbing (pr) and far-red light-absorbing (pfr) forms of phytochrome are differentially retained on an anion exchange matrix to purify m. caldario ...	2008	2324111
long-term clearance of inhaled uo2 particles from the pulmonary region of the rat.	this paper reports on an enriched uranium dioxide (uo2) mass clearance study undertaken with fischer-344 rats. the uo2 had a uranium (u) isotopic composition of 0.79% 234u, 92.8% 235u, 0.34% 236u and 6.06% 238u, by mass, with an alpha-particle activity of 1.91 bq micrograms-1. forty-six rats were exposed to an enriched uo2 aerosol that had an activity median particle aerodynamic diameter ranging from 2.7 to 3.2 microns. the rats were killed from 1 to 720 d post-inhalation (pi). the mass of enric ...	1990	2323929
primary vibrio vulnificus sepsis in kentucky.	vibrio vulnificus is associated with infection acquired during contact with sea water or with seafood, and is seldom suspected by physicians in noncoastal states. the ease of transportation of fresh raw seafood has facilitated this organism's capacity to produce disease in geographic areas in which it was previously unseen. we have reported a case of fatal vibrio vulnificus sepsis acquired from ingestion of fresh oysters in the inland united states.	1990	2315791
digestibility of cotton plant by-product diets for sheep at two levels of intake.	crossbred wethers (n = 48) were assigned randomly to 1 of 12 experimental diets, arranged in a 3 x 2 x 2 split plot to evaluate three levels of cotton plant by-product (25, 50 and 75% cpb), two levels of naoh treatment of cpb (0 and 4%) and two levels of monensin supplementation (0 and 30 ppm, dm basis) at two intake levels (70 and 90% of ad libitum). intake was a within-lamb variable. ad libitum intake was established over an initial 17-d adjustment period. feed intake and fecal output were rec ...	1990	2312420
vibrio vulnificus infections in the hand. report of three patients.		1990	2303515
polyvibrio infections: vibrio vulnificus and vibrio parahaemolyticus dual wound and multiple site infections.		1990	2299220
osteomyelitis caused by vibrio vulnificus.		1990	2299219
vibrio vulnificus wound infection treated successfully with oral ciprofloxacin.		1990	2299188
early response with clomipramine in obsessive compulsive disorder--a placebo controlled study.	1. clomipramine has been found to be effective in the treatment of obsessive compulsive disorder (ocd) in nine placebo controlled studies whereas other conventional antidepressants lacking 5-ht reuptake inhibiting properties do not appear to be effective. 2. the placebo response rate in ocd is very low as is seen in the placebo controlled study of the efficacy of clomipramine 75mg in 14 patients suffering from ocd reported here. 3. response appears early in treatment when compared with response ...	2008	2293252
[technical problems of various sanitary-hygienic aspects of a medical unit on space aircraft].		2008	2292877
[a case of asymptomatic course of kidney tumor].		2008	2292876
[regional blood lactate level in arterial occlusive diseases].	fifty-seven patients with obliterating diseases of the lower limb arteries were examined. the concentration of lactate in the venous blood and the venous-arterial difference in the blood lactate level in the affected limb were found to be increased. a relationship between the marked character of these shifts and the severity of the ischemic syndrome was noted. the authors discuss the possibility of using the values of the lactate content in the regional blood as criteria for evaluating the effic ...	2008	2292851
generation of affinity for antithrombin iii by supplemental sulfation of heparin species with low affinity for the protein.	the tributylammonium salt of a porcine heparin subfraction with low affinity for antithrombin iii (mr 7,500-18,000; anti-clotting activity, 7 usp units/mg), having degrees of sulfate substitution at d-glucosamine and l-iduronic acid residues of glcns 0.786, glcn6s 0.628, and idoa2s 0.682 mol, was reacted with 10 or 20 mol of pyridine-sulfur trioxide per mol equiv. of available hydroxyl groups in n,n-dimethylformamide at -10 degrees c for 1 h. both chemical and nmr spectroscopic analyses revealed ...	1990	2292586
hepatitis b surface antigen seroconversion in resident doctors.		2008	2292578
[bronchial hyperresponsiveness to histamine in guinea pig induced by intravenous administration of platelet activating factor].	platelet activating factor (paf) has recently been demonstrated to play an important role in allergic diseases such as bronchial asthma. changes in airway wall thickness have recently been suggested to cause excess airway narrowing of asthma. in this study, the authors examined the bronchial hyperresponsiveness to histamine in guinea pig induced by intravenous administration of paf by measuring dynamic compliance and dynamic respiratory resistance. moreover, a new formula which can exclude the e ...	1990	2290229
incidence of vibrio vulnificus in northern new england water and shellfish.	vibrio vulnificus, an autochthonous inhabitant of the estuarine environment, was detected in water and oysters from the great bay estuary system of new hampshire and maine. previously, it had not been detected north of boston harbor on the east coast of the united states. v. vulnificus was detected in water and shellfish samples at five out of ten sites, and only in areas that were not open to recreational shellfishing. although samples were collected from may into december, v. vulnificus was on ...	1990	2283033
a successfully treated case of vibrio vulnificus septicemia with shock.	vibrio vulnificus infection often causes serious or fatal disease. recently, in japan there have been numerous reports of vibrio vulnificus infection. here, we report a successfully treated case of vibrio vulnificus septicemia with shock, disseminated intravascular coagulation (dic) and necrotizing cellulitis in a middle-aged heavy drinker with chronic alcoholic liver disease. on reviewing 38 cases in japan including ours, the overall mortality rate was 68%. although the incidence is relatively ...	1990	2273613
tuberculous meningitis. 23 cases from a 12-year period (1976-1987).	twenty-three patients with tuberculous meningitis were reviewed to see whether clinical features or initial laboratory findings could discriminate between these patients and other patients with bacterial meningitis. nineteen patients were danes and four immigrants. preexisting diseases were found in eight cases. duration of symptoms could be related to neurological sequelae, but not to death. the initial clinical picture was indistinguishable from meningitis of other causes. microscopy of the ce ...	1992	2272213
a double-blind comparison of 0.5% bupivacaine and 0.75% ropivacaine administered epidurally in humans.	in an attempt to compare equipotent doses of epidurally administered bupivacaine and ropivacaine, 44 healthy patients, aged 18-70 years, undergoing lower extremity orthopedic procedures were studied in a randomized, double-blind manner. twenty-one patients received a single epidural injection of 20 ml 0.5% bupivacaine at the l23 or l34 interspace and 23 patients received 20 ml 0.75% ropivacaine in a similar manner. onset of and recovery from sensory anesthesia and motor block were recorded. no s ...	1990	2271468
fractionated ifosfamide therapy produces a time-dependent increase in ifosfamide metabolism.	1. fifteen patients received 1.5 g m-2 of ifosfamide intravenously over 0.5 h every day for 5 days. twenty-one courses of treatment were studied. plasma was assayed for ifosfamide by gas liquid chromatography and plasma alkylating activity was measured using the nitrobenzylpyridine (nbp) reaction. 2. a pharmacokinetic analysis revealed a significant decrease in the median (range) elimination half-life of ifosfamide from 7.2 (2.8-14.2) h on day 1 to 4.6 (2.3-7.7) h on day 5 (p less than 0.001, wi ...	2008	2271371
proteolytic processing of porcine big endothelin-1 catalyzed by cathepsin d.	cathepsin d, a candidate for endothelin-converting enzyme (ece), was allowed to act on porcine big endothelin-1 (big et-1, 1-39). the proteinase primarily cleaved the asp18-ile19 and trp21-val22 bonds of big et-1(1-39), with a optimum ph of 3.5. the mature et-1(1-21), generated by the cleavage between trp21 and val22, was subsequently degraded by removal of most of the c-terminal tripeptide (ile19-ile20-trp21). therefore, cathepsin d is by no means a specific ece, although the proteinase does cl ...	1990	2268325
age distribution of erythrocyte population in late pregnancy.	the age population distribution of erythrocytes in late pregnancy was evaluated by the volume and density distribution of cells. this approach enables an evaluation of the life span of erythrocytes in the circulation without using radioactive elements. a younger cell population was found in the circulation of women in late pregnancy as compared to nonpregnant women of similar ages, which might be indicative of shortened life span of erythrocytes. this shortened life span might be explained by th ...	2008	2265799
tcnu in adenocarcinoma of the lung: a phase ii study with divided doses.	tcnu, a new water soluble nitrosourea, has in preclinical studies shown higher activity when given as divided doses compared with one day single treatment. accordingly, 38 consecutive patients with non-resectable adenocarcinoma of the lung received tcnu 40 mg/m2 p.o. daily for three days every 4 weeks. the response rate among 37 evaluable patients was 14%, median response duration was 17 weeks (range 5-57+ weeks) and median survival 22 weeks (range 3-96+ weeks). hematologic toxicity was pronounc ...	2008	2265139
[a training program after coronary surgery improves blood lipid profile].		2008	2263103
[early and long-term results of percutaneous transluminal coronary angioplasty in angina pectoris].		2007	2258666
[early and long-term results of percutaneous transluminal coronary angioplasty in angina pectoris].		2007	2258666
neonatal monosodium glutamate abolishes corticotropin-releasing factor-induced epileptogenic activity in rats.	intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rcrf) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. such an effect was still present in rats neonatally treated with saline but was absent in those neonatally treated with monosodium glutamate (msg), a treatment that caused marked changes in the concentration of several brain neurotransmitters and neuropeptides in hypoth ...	1990	2245800
neonatal monosodium glutamate abolishes corticotropin-releasing factor-induced epileptogenic activity in rats.	intracerebroventricular (i.c.v.) injection of rat corticotropin-releasing factor (rcrf) at doses of 5-20 micrograms in rats induces epileptogenic activity characterized by pacemaker-like spikes localized in the hippocampal leads. such an effect was still present in rats neonatally treated with saline but was absent in those neonatally treated with monosodium glutamate (msg), a treatment that caused marked changes in the concentration of several brain neurotransmitters and neuropeptides in hypoth ...	1990	2245800
[focal liver lesions as incidental findings. 2: diagnostic procedures in sonographically homogeneous echo-rich, echo-poor or inhomogeneous lesions].	hemangioma is one of the most common incidental findings in the ultrasonographic image. in 80% to 90% of the cases, the hemangioma presents as a homogeneous lesion in the us image. in asymptomatic patients and a lesion diameter of less than 2 cm, further clarification additional to ultrasonography is not necessary. major differential diagnoses are focal nodular hyperplasia, metastasis, hepatocellular carcinoma and liver cell adenoma. with exceptions, the biological significance of echo-poor or i ...	2008	2242838
resuscitation of patients with cardiac arrest by ambulance staff with extended training in west yorkshire.	to investigate the results of resuscitation of patients with cardiac arrest by ambulance staff with extended training in west yorkshire.	2006	2242460
abelson murine leukemia virus transforms preneoplastic emu-myc transgene-carrying cells of the b-lymphocyte lineage into plasmablastic tumors.	e mu-myc transgenic mice were back-crossed to balb/c mice up to back-cross generation 3. the offspring that included transgene-carrying and -negative mice in approximately equal proportions were randomly divided into 2 groups. thirty-four mice (group i) were treated with pristane, followed by a-mulv, and 40 (group ii) were injected with a-mulv alone. altogether, 16 lymphoid tumors developed in group i and 17 in group ii. nine of the tumors in group i and 4 in group ii appeared as ascitic tumors. ...	1990	2228313
[initial attitudes to orthodontic treatment--the results of a practical and clinical questionnaire study (i)].	312 patients from one clinic and nine offices, between eight and 15 years of age treated with bionators, their parents and a control group were questioned on various aspects of their treatment. findings regarding opinions about dentofacial appearance, initial motives and expectations are presented. aesthetic motives proved preponderant by seeking treatment though the children's ability to verbally differentiate aesthetic concepts was poor. above all, they expected visible treatment progress, abs ...	2007	2227739
[initial attitudes to orthodontic treatment--the results of a practical and clinical questionnaire study (i)].	312 patients from one clinic and nine offices, between eight and 15 years of age treated with bionators, their parents and a control group were questioned on various aspects of their treatment. findings regarding opinions about dentofacial appearance, initial motives and expectations are presented. aesthetic motives proved preponderant by seeking treatment though the children's ability to verbally differentiate aesthetic concepts was poor. above all, they expected visible treatment progress, abs ...	2007	2227739
[growth and therapy in angle class ii/2--a longitudinal cephalometric study].	the influence of both growth and functional therapy with the u-bow-activator type i on angle class ii subdivision 2 malocclusion is analysed in a cephalometric long term study. findings concerning skeletal problems: 1. therapeutically intended clockwise rotation of the mandible with vertically and sagittally controlled maxillary position, 2. achieving normal sagittal mandibular growth rates. dental problems are improved significantly. the results obtained by functional therapy and growth proved ...	2007	2227736
[growth and therapy in angle class ii/2--a longitudinal cephalometric study].	the influence of both growth and functional therapy with the u-bow-activator type i on angle class ii subdivision 2 malocclusion is analysed in a cephalometric long term study. findings concerning skeletal problems: 1. therapeutically intended clockwise rotation of the mandible with vertically and sagittally controlled maxillary position, 2. achieving normal sagittal mandibular growth rates. dental problems are improved significantly. the results obtained by functional therapy and growth proved ...	2007	2227736
intrathecal administration of 131i radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.	fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mci of a 131i radiolabelled monoclonal antibody (moab), chosen for its immunoreactivity to tumour. major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). nine patients were evaluable for either a tumour or clinical response. six of these demonstrated an event-free response that was maintaine ...	2007	2223581
intrathecal administration of 131i radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.	fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mci of a 131i radiolabelled monoclonal antibody (moab), chosen for its immunoreactivity to tumour. major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). nine patients were evaluable for either a tumour or clinical response. six of these demonstrated an event-free response that was maintaine ...	2007	2223581
fluorosis, osteopetrosis, and ectopic calcification.		2007	2223455
fluorosis, osteopetrosis, and ectopic calcification.		2007	2223455
[diagnosis and surgical treatment of traumatic damage to the sinus of valsalva following penetrating wounds of the heart].	the authors had three patients with traumatic damage of the sinus of valsalva, caused by penetrating injury of the thorax inflicted with a knife. the patients were brought to the clinic in a grave condition with decompensation of systemic and pulmonary circulation. the anomaly called for emergency surgical correction under conditions of extracorporeal circulation. the diagnosis was based on the complaints, medical history, clinical picture, the results of functional methods of examination includ ...	2007	2223226
[diagnosis and surgical treatment of traumatic damage to the sinus of valsalva following penetrating wounds of the heart].	the authors had three patients with traumatic damage of the sinus of valsalva, caused by penetrating injury of the thorax inflicted with a knife. the patients were brought to the clinic in a grave condition with decompensation of systemic and pulmonary circulation. the anomaly called for emergency surgical correction under conditions of extracorporeal circulation. the diagnosis was based on the complaints, medical history, clinical picture, the results of functional methods of examination includ ...	2007	2223226
[a congenital esophagotracheal fistula in an adult].		2007	2223222
[a congenital esophagotracheal fistula in an adult].		2007	2223222
[the importance of the compensatory powers of the lungs in determining the indications for surgical treatment of hypoplasia of the lungs].	the author studied the compensatory possibilities of pulmonary respiration, gas exchange and hemodynamics of pulmonary circulation to determine the indications for operative treatment of simple hypoplasia of the lungs. the work is based on the results of examination of 58 patients. forty-five patients underwent an operation. it was established that simple hypoplasia of the lungs is characterized by mild ventilation disorders and deep disorders of gas exchange leading to manifest and latent hypox ...	2007	2223215
[the importance of the compensatory powers of the lungs in determining the indications for surgical treatment of hypoplasia of the lungs].	the author studied the compensatory possibilities of pulmonary respiration, gas exchange and hemodynamics of pulmonary circulation to determine the indications for operative treatment of simple hypoplasia of the lungs. the work is based on the results of examination of 58 patients. forty-five patients underwent an operation. it was established that simple hypoplasia of the lungs is characterized by mild ventilation disorders and deep disorders of gas exchange leading to manifest and latent hypox ...	2007	2223215
[lung cancer in women in moscow (epidemiology, etiology and surgical treatment)].	in the studied period (1973-1987) the lung carcinoma morbidity rate among females of moscow, in general intensive indices (per 100,000 females), showed a tendency to reduce (18.4 in 1973 and 15.1 in 1987). a reverse tendency is mostly encountered in other countries. more than half of patients with lung carcinoma were over 70 years of age. the ratio of males with lung carcinoma to that of females grew from 3.0:1.0 in 1973-1977 to 3.6:1.0 in 1983-1987. in the period from 1979 to 1988, 380 females ...	2007	2223213
[lung cancer in women in moscow (epidemiology, etiology and surgical treatment)].	in the studied period (1973-1987) the lung carcinoma morbidity rate among females of moscow, in general intensive indices (per 100,000 females), showed a tendency to reduce (18.4 in 1973 and 15.1 in 1987). a reverse tendency is mostly encountered in other countries. more than half of patients with lung carcinoma were over 70 years of age. the ratio of males with lung carcinoma to that of females grew from 3.0:1.0 in 1973-1977 to 3.6:1.0 in 1983-1987. in the period from 1979 to 1988, 380 females ...	2007	2223213
massive rhabdomyolysis: a rare presentation of primary vibrio vulnificus septicemia.		1990	2220890
determination of the affinity of a steroid for its receptor is not sufficient to measure its intrinsic hormonal activity.		2007	2219201
determination of the affinity of a steroid for its receptor is not sufficient to measure its intrinsic hormonal activity.		2007	2219201
personal power: your key to success.		2007	2216083
in vitro activity of ljc10,627, a new carbapenem antibiotic with high stability to dehydropeptidase i.	the in vitro activity of ljc10,627, a new carbapenem, was compared with those of imipenem and ceftazidime. ljc10,627 had broad-spectrum activity against gram-positive and gram-negative clinical isolates. the mics of this compound for 90% of members of the family enterobacteriaceae tested (mic90s), including strains resistant to ceftazidime, ranged from 0.1 to 25 micrograms/ml. ljc10,627 inhibited pseudomonas aeruginosa at an mic90 of 3.13 micrograms/ml; it thus was twofold more active than imipe ...	1990	2203313
[a case of fatal sepsis due to vibrio vulnificus].	a 66-year-old male with chronic alcoholic liver injury was admitted on july 27, 1986 to our hospital with complaints of high fever, convulsion and skin erythema. he had consumed raw fish 3 days before, and had a scratch wound over the right arm and left leg because he had slipped in a small stream in the woods the day before admission. he was already in shock state with sepsis of v. vulnificus and dic on admission. although the treatment with abpc, cp, caz, mino for sepsis, and heparin & antithr ...	1990	2187037
[amalgam discussion. question of amalgam toxicity and allergy].		2007	2171028
proton-nuclear magnetic resonance relaxation times in brain edema.	proton relaxation times of protein solutions, bovine brain, and edematous feline brain tissue were studied as a function of water concentration, protein concentration, and temperature. in accordance with the fast proton exchange model for relaxation, a linear relation could be established between r1 and the inverse of the weight fraction of tissue water. this relation also applied to r2 of gray matter and of protein solutions. no straightforward relation with water content was found for r2 of wh ...	1990	2168666
mechanisms underlying the stimulation of pth release by gppnhp in permeabilized bovine parathyroid cells.	we examined changes in camp and inositol phosphate metabolism to assess the contribution of the guanine nucleotide regulatory (g) protein(s) regulating adenylate cyclase and phospholipase c in mediating the stimulatory effects of gppnhp on pth release from permeabilized bovine parathyroid cells. to examine the role of gs, the g protein stimulating adenylate cyclase, and camp on pth release, permeabilized cells were incubated with either gppnhp or isoproterenol, and the effects of these agents on ...	1990	2168660