Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| evidence that stimulation of growth hormone release by epinephrine and vasoactive intestinal peptide is based on cell-to-cell communication in the pituitary. | epinephrine (epi) evoked a strong concentration-dependent (1-1000 nm) rise of gh release from perifused rat anterior pituitary cells cultured as aggregates in a serum-free defined culture medium. dexamethasone (dex), added to the culture medium, enhanced the secretory response to epi. aggregates of pituitary cells separated by gradient sedimentation at unit gravity widely differed in responsiveness to epi, provided dex was added to the culture medium. the poorest response was seen in aggregates ... | 1987 | 3023029 |
| evidence that stimulation of growth hormone release by epinephrine and vasoactive intestinal peptide is based on cell-to-cell communication in the pituitary. | epinephrine (epi) evoked a strong concentration-dependent (1-1000 nm) rise of gh release from perifused rat anterior pituitary cells cultured as aggregates in a serum-free defined culture medium. dexamethasone (dex), added to the culture medium, enhanced the secretory response to epi. aggregates of pituitary cells separated by gradient sedimentation at unit gravity widely differed in responsiveness to epi, provided dex was added to the culture medium. the poorest response was seen in aggregates ... | 1987 | 3023029 |
| differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro. | transforming growth factor type beta (tgf-beta) suppresses basal as well as corticotropin (acth)-stimulated steroid formation by bovine adrenocortical cells in culture. the effect is dose dependent and is not accompanied by any change in adrenocortical cell growth. the minimum effective dose of tgf-beta is 4 x 10(-13) m (10 pg/ml), and maximal inhibition is observed at a concentration of 4 x 10(-11) m (1 ng/ml). a 16- to 20-hr incubation with tgf-beta is required to decrease steroidogenesis, and ... | 1986 | 3020557 |
| differential effects of transforming growth factor type beta on the growth and function of adrenocortical cells in vitro. | transforming growth factor type beta (tgf-beta) suppresses basal as well as corticotropin (acth)-stimulated steroid formation by bovine adrenocortical cells in culture. the effect is dose dependent and is not accompanied by any change in adrenocortical cell growth. the minimum effective dose of tgf-beta is 4 x 10(-13) m (10 pg/ml), and maximal inhibition is observed at a concentration of 4 x 10(-11) m (1 ng/ml). a 16- to 20-hr incubation with tgf-beta is required to decrease steroidogenesis, and ... | 1986 | 3020557 |
| substrate phosphoprotein availability regulates eclosion hormone sensitivity in an insect cns. | the final step in the moulting of all insects is ecdysis, the shedding of the cuticle of the previous instar, which is triggered in lepidoptera by the neurosecretory peptide eclosion hormone. this hormone acts directly on the nervous system to release the appropriate motor patterns for larval, pupal and adult ecdysis, but there are only brief periods near the end of each moult when the nervous system is competent to respond to the hormone. previous experiments have shown that the action of eclos ... | 1986 | 3020427 |
| substrate phosphoprotein availability regulates eclosion hormone sensitivity in an insect cns. | the final step in the moulting of all insects is ecdysis, the shedding of the cuticle of the previous instar, which is triggered in lepidoptera by the neurosecretory peptide eclosion hormone. this hormone acts directly on the nervous system to release the appropriate motor patterns for larval, pupal and adult ecdysis, but there are only brief periods near the end of each moult when the nervous system is competent to respond to the hormone. previous experiments have shown that the action of eclos ... | 1986 | 3020427 |
| the effects of furosemide on adenosine 3':5'-cyclic monophosphate, guanosine 3':5'-cyclic monophosphate and corticosterone production stimulated by adrenocorticotropin in monolayer cultured rat adrenal cells. | furosemide has been reported to have a suppressive effect on adh-, pth- and adrenaline-stimulated adenosine 3':5'-cyclic monophosphate (camp) production, but the effect on adrenocorticotropin (acth) action has not yet been elucidated. in the present study, therefore, the effects of furosemide on camp and also on guanosine 3':5'-cyclic monophosphate (cgmp) and corticosterone, stimulated by acth in monolayer cultured rat adrenal cells, were investigated. the intra- and extracellular camp stimulate ... | 1986 | 3019648 |
| the effects of furosemide on adenosine 3':5'-cyclic monophosphate, guanosine 3':5'-cyclic monophosphate and corticosterone production stimulated by adrenocorticotropin in monolayer cultured rat adrenal cells. | furosemide has been reported to have a suppressive effect on adh-, pth- and adrenaline-stimulated adenosine 3':5'-cyclic monophosphate (camp) production, but the effect on adrenocorticotropin (acth) action has not yet been elucidated. in the present study, therefore, the effects of furosemide on camp and also on guanosine 3':5'-cyclic monophosphate (cgmp) and corticosterone, stimulated by acth in monolayer cultured rat adrenal cells, were investigated. the intra- and extracellular camp stimulate ... | 1986 | 3019648 |
| studies on enterotoxin of shigella dysenteriae type 1. ii. systemic effects in rabbits of shigella dysenteriae 1 enterotoxin. | the enterotoxin of shigella dysenteriae type 1 is an acid and heat-labile protein. it induces a gut dilatory response and increases the levels of blood glucose, serum alkaline phosphatase and serum acid phosphatase in rabbits. | 1986 | 3019069 |
| [response of polymorphonuclear neutrophils to monosodium urate crystals: production of oxygen free radicals]. | 2006 | 3013256 | |
| [hypothesis on the probable mechanism of auto-limitation of acute attacks of gout]. | 2006 | 3013255 | |
| cloning and expression of the genes specifying shiga-like toxin production in escherichia coli h19. | some strains of escherichia coli produce a protein which is cytotoxic for vero cell and hela cell monolayers. this toxin is very similar to the toxin of shigella dysenteriae 1 and has been named verotoxin or e. coli shiga-like toxin. it has been shown that toxin conversion is due to a group of bacteriophages, one of which has been designated h-19b. in this study we report hybridization experiments showing that part of the h-19b genome is homologous to phage lambda. we have cloned a 1.7-kilobase ... | 1986 | 3009393 |
| complete dissociation between the activation of phosphoinositide turnover and of nadph oxidase by formyl-methionyl-leucyl-phenylalanine in human neutrophils depleted of ca2+ and primed by subthreshold doses of phorbol 12,myristate 13,acetate. | evidences have been provided by many laboratories that the activation of the nadph oxidase in neutrophils by formyl-methionyl-leucyl-phenylalanine (fmlp) is strictly linked to a transduction pathway that involves the stimulation, via gtp binding protein, of the phosphoinositide turnover and the increase in [ca2+]i. the results presented in this paper demonstrate that fmlp can activate the nadph oxidase by triggering a transduction pathway completely independent of phosphoinositide turnover and c ... | 1986 | 3008746 |
| near infrared optical monitoring of intact skeletal muscle during hypoxia and hemorrhagic hypotension in cats. | 1985 | 3008518 | |
| lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates. | we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ... | 2010 | 3006037 |
| lateral diffusion of specific antibodies bound to lipid monolayers on alkylated substrates. | we have measured the lateral mobility of fluoresceinated monoclonal igg antibodies bound specifically to a spin label lipid hapten in phospholipid monolayers supported on alkylated silicon oxide surfaces. dimyristoyl phosphatidylcholine and dipalmitoyl phosphatidylcholine monolayers containing 5 mol% of the lipid hapten were transferred by conventional langmuir-blodgett techniques onto substrates alkylated with hydrocarbon chains containing 10, 16, and 18 carbon atoms. we show that the diffusion ... | 2010 | 3006037 |
| meiotic recombination between two polymorphic restriction sites within the beta globin gene cluster. | analysis of beta globin gene haplotypes for prenatal diagnosis of beta thalassaemia has revealed a recombination event within the beta globin gene cluster. both a change in the avaii polymorphic site within the beta globin gene and a change in the phenotype of the beta globin gene were observed. paternity was established by the pedigree analysis of hypervariable 'minisatellite' dna polymorphisms and the most probable explanation of the recombination event is a crossover between the psi beta glob ... | 2010 | 3005579 |
| [experimental basis for the use of collagenase preparations to prevent aging of the skin]. | 1985 | 3004061 | |
| interaction of stable prostaglandin endoperoxide analogs u46619 and u44069 with human platelet membranes: coupling of receptors with high-affinity gtpase and adenylate cyclase. | it has been demonstrated using a membrane preparation of human platelets that stable analogs of pgh2, u46619 and u44069, control the activity of adenylate cyclase and a high-affinity hormone-sensitive gtpase. at 10(-8)-10(-6) m, the analogs inhibit the basal activity of adenylate cyclase by 20-25%. with a further rise in u46619 and u44069 concentrations up to 10(-5)-10(-4) m, the inhibition is abolished and adenylate cyclase activity is stimulated in a dose-dependent fashion. in the presence of ... | 1985 | 3003958 |
| blood concentration and urinary excretion of enalapril in patients with chronic renal failure. | 2010 | 3003431 | |
| synaptic transmission in the rabbit inferior mesenteric ganglion. | electrical properties, cholinergic neurotransmission and non-cholinergic neurotransmission in the rabbit inferior mesenteric ganglion (img) in vitro were examined with intracellular recording techniques. a single ganglionic neuron received an average of 42 nicotinic cholinergic synaptic inputs. an atropine-sensitive slow excitatory postsynaptic potential not followed by a non-cholinergic late slow excitatory postsynaptic potential (ls-epsp) was observed in 7% of the cells. in 63% of the cells a ... | 1985 | 3003179 |
| repression of adenovirus early gene expression by coinfection with a temperature-sensitive mutant in the immediate-early gene of pseudorabies virus. | wild-type adenovirus was coinfected with a mutant temperature sensitive for the immediate-early gene of pseudorabies virus. at the nonpermissive temperature, this mutant, tsg, strongly inhibited the transcription of all adenovirus early genes, including e1a. this inhibition was not observed with wild-type pseudorabies virus coinfection or with tsg coinfection at the permissive temperature. the level of repression was dependent upon the ratio of tsg to adenovirus in the infection. the results sug ... | 1986 | 3001339 |
| elicitation of conspecific attack or defense in the male rat by intraventricular injection of a gaba agonist or antagonist. | the involvement of central gabaergic mechanisms in the control over offensive and defensive behaviours in the rat was studied using intracerebroventricular injections (5 microliter) of a gaba agonist (thip) or a gaba antagonist (bicuculline methiodide). intracerebroventricular injections of thip (1.25 and 2.5 micrograms) induced attacks and offensive sideways towards an untreated partner, in animals placed in a neutral area where no aggressive reactions occur in controls. social approach behavio ... | 1985 | 2999844 |
| elicitation of conspecific attack or defense in the male rat by intraventricular injection of a gaba agonist or antagonist. | the involvement of central gabaergic mechanisms in the control over offensive and defensive behaviours in the rat was studied using intracerebroventricular injections (5 microliter) of a gaba agonist (thip) or a gaba antagonist (bicuculline methiodide). intracerebroventricular injections of thip (1.25 and 2.5 micrograms) induced attacks and offensive sideways towards an untreated partner, in animals placed in a neutral area where no aggressive reactions occur in controls. social approach behavio ... | 1985 | 2999844 |
| the biologic significance of the mixed lymphocyte kidney culture in humans. | the mixed lymphocyte kidney culture (mlkc) in humans has been studied in normal and abnormal clinical conditions. human renal cortical cells were extracted by collagenase treatment from the kidneys of "normal" heart-beating cadaver organ donors (n = 13), patients with end-stage renal disease (esrd) at pretransplant bilateral nephrectomy and splenectomy (n = 13), and from irreversibly rejected renal allografts at the time of graft nephrectomy (n = 5). proliferation of peripheral blood t lymphocyt ... | 1985 | 2996186 |
| induction of cellular dna synthesis by a simian virus 40 mutant defective in nuclear transport of t antigen. | the simian virus 40 (sv40) (ct)-3 mutant [sv40(ct)-3], which is defective in nuclear transport of t antigen, was utilized to determine whether cellular dna synthesis can be stimulated by sv40 in the absence of detectable nuclear t antigen. cellular dna synthesis was examined in the temperature-sensitive cell cycle mutants, bhk ts13 and bhk tsaf8, after microinjection of quiescent cells with plasmid dna containing cloned copies of wild-type sv40 or sv40(ct)-3. the efficiency of induction of cellu ... | 1985 | 2993869 |
| immunologic characterization of herpes simplex virus type 2 antigens icp10 and icsp11/12. | infected cell protein 10 (icp10) or antigen 4 (ag4) and infected cell-specific protein 11/12 (icsp11/12) have been suggested as specific antigenic markers for cervical carcinoma. experiments were designed to determine whether icp10 and icsp11/12 are distinct antigens and to determine the cellular localization of icp10. results indicate that an apparent 160 kdalton (kda) protein analyzed by 8.5% polyacrylamide gels (= 144 kda protein analyzed by 7.0% polyacrylamide gels) was detected in hsv-2-inf ... | 1985 | 2988230 |
| serologic survey of rotavirus, norwalk agent and prototheca wickerhamii in wastewater workers. | analysis of paired sera from 48 wastewater workers and controls who reported gastrointestinal illness did not reveal any excess of seroconversions to norwalk agent or to rotavirus. inexperienced wastewater-exposed workers had higher levels of antibody to norwalk agent than did experienced and control workers and those with high and medium aerosol exposure had higher titres than those in the low aerosol category. analysis for prototheca antibody titres was essentially negative. | 1985 | 2981485 |
| middle tumor antigen of polyomavirus transformation-defective mutant ng59 is associated with pp60c-src. | we have found that lysis of mouse embryo cells infected with the polyomavirus host range transformation-defective (hr-t) mutant ng59 under gentle conditions that avoid ionic detergents results in detectable ng59-encoded middle tumor antigen (mtag) associated with pp60c-src. this mtag-pp60c-src complex could be immunoprecipitated from ng59-infected cell lysates by either sera from animals bearing polyomavirus-induced tumors or by monoclonal antibodies directed against mtag. immune complex kinase ... | 1985 | 2981329 |
| plasma atrial natriuretic peptide concentrations during induction of anesthesia and acute volume loading in patients undergoing cardiac surgery. | induction of anesthesia with fentanyl for coronary artery bypass grafting decreased (p less than .05) plasma atrial natriuretic peptide (anp) concentrations from awake values in twelve patients. during a steady state of anesthesia before surgery, isotonic saline solution (10 ml/kg) was infused simultaneously with the elevation of the lower extremities in six patients, while six subjects served as controls receiving no volume loading and having no leg raising. the anp levels returned to the awake ... | 2010 | 2980951 |
| principles of the diagnostic system 'orfèvre' for computerized analysis in radiology. | 2010 | 2980470 | |
| the relationships between oligomeric structure and function of band 3 protein from human erythrocyte membranes: present knowledge and suggestions for further experiments. | 1988 | 2976450 | |
| [prevention of the problems of alcoholism]. | 2010 | 2975175 | |
| [current approaches to immunological diagnosis of autoimmune and immune complex diseases]. | 2010 | 2974642 | |
| [fibrinolytic therapy of thromboembolic vascular occlusions: experiences based on 87 patients]. | 2010 | 2974192 | |
| [pathological aging of the brain. personal observations on the use of citicoline]. | 2010 | 2973933 | |
| neuroendocrine effects of diazepam in normal subjects following brief painful stress. | the neuroendocrine effects of 5 and 10 mg of oral diazepam were assessed in 10 normal subjects under baseline (prestress) and laboratory-controlled stressful conditions. although the 10-mg diazepam dose had no effect on cortisol at baseline, it significantly reduced the increase in cortisol produced by 15 minutes of exposure to a painful electrical stimulus. there were no significant effects on growth hormone, beta-endorphin or acth, either at baseline or after painful stimulation. | 2003 | 2972756 |
| the "phantom" optic nerve. demonstration in ct and mr scans 19 years after resection of optic glioma. | 2003 | 2972753 | |
| epidemiological aspects of plasmid profiles in shigella dysenteriae type 1 strains isolated from burma & india. | 1987 | 2967798 | |
| [193 cases of gastroschisis and omphalocele--postoperative results]. | treatment was applied to 97 cases of omphalocele and 96 cases of gastroschisis at the dortmund department of paediatric surgery over the past 20 years. the survival rate was 122. follow-up checks were recently applied to 56 of those former patients, after nearly ten years had elapsed from surgery. thirty-eight of these patients were clinically examined, while questionnaires were completed for the rest. primary closures had been performed on 50 per cent of the cases, while the defects in the othe ... | 2010 | 2966527 |
| [effect of nicotinic acid, nicotinamide and its combination with ziksorin and phenobarbital on the udp glucuronyl transferase activity of the hepatic endoplasmic reticulum in the rat]. | nicotinic acid and nicotinamide (100 mg/kg) increase the activity of the rat liver microsomal uridine diphosphate-glucuronyltransferase by 55 and 73.8%. administration of nicotinamide in combination with ziksorin or phenobarbital enhanced the enzyme-inducing effects of the latter. | 1988 | 2966073 |
| lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. | pantethine in a dosage of 600 mg for the first 3 months, and in a dosage of 1200 mg for the second 6 months was given to 16 diabetics in whom plasma beta-thromboglobulin was raised (greater than 50 ng/ml). plasma beta-tg levels decreased significantly with pantethine treatment for 9 months. plasma triglyceride, total cholesterol, apo e and apo cii levels decreased significantly after 9 months. plasma ldl-c and atherogenic index (ldl-c/hdl-c ratio or apo b/apo ai ratio) tended to decrease with tr ... | 2010 | 2963604 |
| an outbreak of dysentery due to shigella dysenteriae type 1 in rangoon, burma. | 1987 | 2963061 | |
| effect of b cell stimulatory factor-1 (interleukin 4) on fc epsilon and fc gamma receptor expression on murine b lymphocytes and b cell lines. | culture of murine splenic b cells with interleukin 4 (il-4) caused the up-regulation of the lymphocyte fc receptor for immunoglobulin e (ige) (fc epsilon r) over a similar dose range as required for ia up-regulation. however, the expression level of the fc receptor for immunoglobulin g (fc gamma r) did not increase, rather il-4 caused a slight but consistent decrease in the fc gamma r level on the b cells. fc epsilon r+ b hybridoma cells also responded to il-4 by exhibiting increased fc epsilon ... | 1987 | 2958544 |
| comparison of atracurium and d-tubocurarine for prevention of succinylcholine myalgia. | we compared the incidence of postoperative myalgia (pom) and fasciculations when atracurium (atr) or d-tubocurarine (dtc) was given prior to succinylcholine (sdc) for tracheal intubation in 44 asa class i or ii outpatient females undergoing laparoscopy. the subjects were assigned to one of three groups: group 1 received 0.025 mg/kg atr; group 2 received 0.05 mg/kg dtc; and group 3 received saline (ns), all in a double-blind manner. thiopental was administered 1 min and 45 sec after pretreatment ... | 2010 | 2955717 |
| validity of an operational definition for neurotic unipolar major depression. | after we reviewed the literature to identify the clinical and phenomenologic correlates of neurotic depression, we constructed a 6-item operational definition to distinguish neurotic unipolar major depressive disorder from non-neurotic major depression. the neurotic depressives were characterized by a low rate of abnormal dexamethasone suppression test (dst) results and a strong family history of alcoholism. neurotic depressives improved less than non-neurotic depressives during the index hospit ... | 2010 | 2952692 |
| [clinical survey on adverse reactions of contrast media (2d report)]. | 2010 | 2950377 | |
| utilization of formal social support services by non-institutionalized ill elderly. | 2009 | 2948279 | |
| abnormal systolic time intervals in obesity and their relationship with the amount of overweight. | we studied 17 severely obese subjects (age range 26 to 42 years), without hypertension, diabetes mellitus, angina, or clinical signs of heart failure or respiratory disease, and 16 age-matched control subjects. x-teleroentgenographic findings (transverse cardiac diameter and cardiothoracic ratio), blood pressure, and mechanocardiographic parameters were analyzed in both groups. by means of conventional simultaneous recordings of ecg, phonocardiogram, and carotid pulse (100 mm/sec), systolic time ... | 2010 | 2943149 |
| dose-related effects of synthetic human beta-endorphin and naloxone on fed gastrointestinal motility. | in humans, plasma beta-endorphin levels rise during application of acute stressful stimuli (vertigo, cold pain, and transcutaneous electrical stimulation) that induce gut motor disturbances. whereas it is possible that circulating beta-endorphin participates in the mediation of these central effects on gut motility, its role cannot be established solely on the basis of changes in plasma levels. therefore, we designed the present study to investigate 1) the dose-related effects of intravenous syn ... | 1986 | 2942039 |
| the incidence of cardiac arrhythmias during intravenous digital subtraction angiography: a comparison of peripheral and central injections. | intravenous digital subtraction arteriography (iv-dsa) was carried out in 204 patients with arteriosclerotic peripheral vascular disease using the non-ionic contrast medium iopamidol 370. in 124 patients the injection was made into an antecubital vein and in 80 into the right atrium. rhythm strip electrocardiograms showed no significant difference in incidence or type of arrhythmias between either injection method (p greater than 0.95). | 2010 | 2941437 |
| outcome of early surgery after coronary angioplasty. | nineteen of 69 patients undergoing coronary angioplasty required immediate coronary surgery after the procedure. six of these operations were planned as a result of angioplasty that failed without producing any complication. the remaining 13 cases were operated upon because complications occurred during angioplasty. these were coronary artery dissection in four, occlusion in five, continuing severe spasm in two, tamponade in one, and in one other detachment of a guidewire tip. in these 13 cases ... | 2010 | 2937432 |
| solvent interactions with n, n-dialkylnicotinamides and their effects on rotational barriers. | carbon-13 nuclear magnetic resonance techniques were employed to examine the effects of solvent environment on rotational barriers in a series of molecules structurally-related to the analeptic, nikethamide: n,n-dimethylnicotinamide, n,n-di-n-propylnicotinamide, and 1-nicotinoyl piperidine. total bandshape analysis was performed for the exchanging alkyl carbon resonances of these compounds as a function of temperature in four solvent systems: d2o, ch3od, ch3ch2od and cdcl3. the rate constants fo ... | 2010 | 2937406 |
| [hormonal status of girls in the neutral, prepubertal and pubertal periods of life]. | 2010 | 2935044 | |
| [horizontal laparotomy in biliary tract surgery]. | for operations on the biliary tract the transverse horizontal incision has the same advantages as the subcostal approach: strong abdominal wall, little influence on ventilation and wide access to the subhepatic region. but in addition, the abdominal wall nerves are preserved as much as possible, post-operative evisceration, it is occurs, can easily be repaired and subsequent surgery can be performed using the same route. | 2010 | 2934697 |
| [nutrition in the etiology of breast cancer. results of a survey in austria]. | 2010 | 2934651 | |
| adp-ribosylatable content of elongation factor-2 changes during cell cycle of normal and cancerous human cells. | the amount of protein elongation factor ef-2 that can be inactivated by diphtheria toxin-mediated adp-ribosylation, a measure of its active content, decreases by 45% and 66% in g1-arrested normal human fibroblasts and in hela cells respectively. on restimulation of cells with fresh serum, the amounts of adp-ribosylatable ef-2 begin to increase within 4 h. whereas the level of active ef-2 returns to normal (exponential phase of growth) in 20 h in the case of fibroblasts, only 47% recovery was obs ... | 1989 | 2930555 |
| ptsd and suicide attempts by adolescents. | 2010 | 2929769 | |
| nontraditional pedagogy for implementing human genetics education. | 1989 | 2929601 | |
| three potassium currents in mouse motor nerve terminals. | a study of the k conductance of the presynaptic membrane has been performed in the triangularis sterni muscle of the mouse. external currents generated in the presynaptic terminals upon invasion by action potentials have been recorded using microelectrodes inserted into the perineurium of preterminal nerve bundles. the voltage-dependent k current could be pharmacologically dissected into fast (ikf) and slow (iks) components. while both are sensitive to 3,4-diaminopyridine (3,4-dap), only ikf is ... | 1989 | 2928092 |
| functional significance of the kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. | blood coagulation can be initiated when factor vii or viia, a plasma protease, binds to its essential cofactor, tissue factor (tf), and proteolytically activates factors ix and x, triggering a cascade of events which eventually leads to the formation of thrombin and a fibrin clot. plasma contains a lipoprotein-associated coagulation inhibitor (laci) which inhibits activated factor x (xa) directly and, in a xa-dependent way, inhibits vii(a)/tf activity, presumably by forming a quaternary xa/laci/ ... | 2010 | 2927510 |
| anal duct carcinoma. | 2010 | 2924675 | |
| [the treatment of severe, therapy-resistant depression using infusions of antidepressants]. | infusion-therapy with antidepressants has been of value in severe as well as therapy resistant depressive states. in addition to doses lower than those used for oral treatment, a more rapid onset of therapeutic effect and a better tolerance, the beneficial effect seems also to depend on the setting in which the treatment takes place. infusion-therapy is a combined pharmacopsychotherapeutic procedure. next to infusion-treatment a pretreatment with neuroleptics is advised either via the oral or pa ... | 2010 | 2922514 |
| [the administration of calcium channel blockers in patients with cerebrovascular diseases]. | 2010 | 2922083 | |
| sensitivity of campylobacter pylori to colloidal bismuth subcitrate. | 1989 | 2921366 | |
| focus on scotland. taking the high road. interview by sue smith. | 2010 | 2920555 | |
| arrhythmia or artifact? | 2010 | 2916599 | |
| the protective effect of thromboxane synthetase inhibition on renal function in systemic sepsis. | to study the role of thromboxane in systemic sepsis and renal failure, peritonitis was induced surgically in 22 sheep, leading to local and systemic sepsis. a selective thromboxane synthetase inhibitor, u63,557a (upjohn co, kalamazoo, mi) was given before surgery in five animals and 30 minutes after surgery in five animals. a typical picture of volume-loaded, normotensive, vasodilated septic shock developed in all animals. twenty four hours after induction of sepsis, the control group showed a m ... | 1989 | 2916566 |
| [screening of cancer, advantages and disadvantages]. | 2010 | 2916263 | |
| uptake of 63ni2+ in the central and peripheral nervous system of mice after oral administration: effects of treatments with halogenated 8-hydroxyquinolines. | oral administration of 63ni2+ to mice resulted in higher levels of the metal in the sciatic nerves, the trigeminal ganglia, spinal nerve roots and the spinal cord than in the cerebellum and the frontal cortex. in the sciatic nerves, the trigeminal ganglia and the spinal nerve roots a high vascular permeability may explain the preferential uptake of the 63ni2+. the higher accumulation of the 63ni2+ in the spinal cord than in the examined structures of the brain may be related to a diffusion from ... | 2010 | 2916242 |
| arthrodesis of metatarsophalangeal joints in a dog. | chronic osteomyelitis and septic arthritis involving the 3rd and 4th metatarsophalangeal joints were diagnosed in a doberman pinscher. arthrodesis of the 3rd and 4th metatarsophalangeal joints resulted in a subtle persistent gait abnormality, but limb function was preserved. arthrodesis of metatarsophalangeal joints is an alternative to amputation, especially when main weight-bearing digits are involved. | 1989 | 2914800 |
| improved sexual function in hemodialysis patients on recombinant erythropoietin: a possible role for prolactin. | as it was reported that correction of anemia in long-term hemodialysis patients by recombinant human erythropoietin (r-huepo) is associated with improved sexual function, we conducted the present study to further delineate the mechanism(s) by which this is brought about. serum prolactin, testosterone, and parathyroid hormone (pth) levels were followed during 4 months of r-huepo therapy. within 4 months of treatment with r-huepo, hematocrit values rose from 23.7 +/- 1.2 to 35.7 +/- 0.2% and hemog ... | 1989 | 2914405 |
| [the expression of c-myb is strongly associated with the presence of estrogen and progesterone receptors in breast cancer]. | the c-myb gene was studied in 112 breast cancers. c-myb and estrogen receptor (er) transcripts were found in 78 (70%) and 71 (63%) cancers respectively. of these 71 er positive cancers, 64 (90%) contained c-myb transcripts and of the 41 er negative cancers, 27 (66%) did not contain c-myb mrna. our data show that c-myb transcripts are strongly associated with er and progesterone receptors (p less than 10(-4) status in breast cancer. thus the c-myb expression could be associated with breast cancer ... | 2010 | 2907731 |
| brain cellular injury and recovery--horizons for improving medical therapies in stroke and trauma. | an edited summary of an interdepartmental conference arranged by the department of medicine of the ucla school of medicine, los angeles. the director of conferences is william m. pardridge, md, professor of medicine. after ischemic and traumatic brain injury, many cells may be rendered dysfunctional but are not irreversibly damaged or disrupted. the brain tissue may become metabolically deranged, and neurons, while still alive, are paralyzed and cannot create an action potential or conduct an el ... | 1988 | 2902711 |
| molecular neurobiology--a conference sponsored by the nimh. | 2010 | 2902686 | |
| nalidixic-acid resistant shigella dysenteriae type 1 in eastern india. | 1988 | 2902361 | |
| dysentery due to multiresistant shiga bacillus in rural iran. | 1988 | 2902359 | |
| a selective inhibitor of camp-specific phosphodiesterase, ro 20-1724, has no effect on the quantal release of acetylcholine from the mouse phrenic nerve. | the indirect twitch response of the mouse isolated phrenic nerve-diaphragm preparation, partially paralysed by tubocurarine, was restored only by about 10% by ro 20-1724 at 2 to 280 microm. the solvent vehicle, dimethylsulphoxide, also showed the same effect to a similar extent. intracellular recordings with glass microelectrodes revealed that ro 20-1724 (40 microm) affected neither the resting membrane potential, the amplitude and frequency of miniature endplate potentials nor the amplitude of ... | 1988 | 2897454 |
| [endodontic approach to injured teeth]. | 2010 | 2897345 | |
| hay fever treatments--which should be tried first? | a series of comparative trials on nine popular and pharmacologically distinct regimens for the treatment of hay fever was undertaken in the course of normal general practice in the pollen seasons of 1981-83. one hundred and forty doctors recruited 640 patients to assess the overall usefulness of the treatments on daily diaries. ;usefulness' was scored on a linear analogue scale weighing up the degree of hay fever symptoms during treatment, side effects and ease of use of the preparation.the regi ... | 2010 | 2896796 |
| clinical impact of drug resistance. | 1988 | 2896697 | |
| enhancement of contractile responses to partial alpha-adrenoceptor agonists during warming in rat aorta. | we examined the effects of warming on the contractile responses to full and partial alpha-adrenoceptor agonists in rat aorta. the contractions elicited by norepinephrine and methoxamine were not affected during warming (40 degrees c, 42 degrees c), whereas those induced by clonidine and st 587 were significantly enhanced. kcl-induced contractions of rat aorta were not affected by warming. the dissociation constants of clonidine and st 587 at 40 degrees c were not different from those at 37 degre ... | 1987 | 2895427 |
| why does placebo improve severe limb ischaemia? | 2010 | 2893161 | |
| bioactivity and immunoreactivity of tumour necrosis factor in cancer patients. | 2010 | 2893076 | |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| plasmid-mediated resistance to nalidixic acid in shigella dysenteriae type 1. | in an epidemic of shigellosis in southern bangladesh the causal organism, shigella dysenteriae type 1, was resistant to nalidixic acid as well as to co-trimoxazole (trimethoprimsulphamethoxazole) and ampicillin. the genes coding for resistance to nalidixic acid, but not those coding for resistance to co-trimoxazole or ampicillin, are located on a conjugative 20 megadalton plasmid. this epidemic is of particular importance because of the resistance to nalidixic acid, an antibiotic to which shigel ... | 1987 | 2887725 |
| exposure to benzodiazepines in utero. | 2010 | 2884529 | |
| first-trimester prenatal diagnosis for huntington's disease with dna probes. | polymorphic dna probes linked to the locus for huntington disease (hd) were used for prenatal diagnosis of a 10-week fetus at 25% risk for the disease. the fetus proved to have a 48% risk of having inherited the hd mutation which was similar to that for the at-risk parent (50%). on this basis the parents elected to terminate the pregnancy. when appropriate family members are available and dna studies are informative, prenatal diagnosis of hd with polymorphic dna probes can determine the at-risk ... | 2010 | 2884412 |
| comparison of the effects of fe2+ and cu2+ on prostaglandin synthesis in rabbit kidney medulla slices. | the effects of fe2+ and cu2+ on the generation of medullary prostaglandins e2 and f2 alpha have been compared. fe2+ markedly promoted the lipid peroxidation of rabbit kidney medulla slices. the lipid peroxidation induced by fe2+ inhibited both prostaglandin e2 and prostaglandin f2 alpha formation to a similar extent. while cu2+ produced only a small increase in lipid peroxidation, it had a powerful inhibitory effect on prostaglandin e2 formation. simultaneously, prostaglandin f2 alpha production ... | 1987 | 2883291 |
| media for isolating shigella. | 1987 | 2881104 | |
| an n-methyl-d-aspartate (nmda) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures. | we investigated the actions of a specific n-methyl-d-aspartate (nmda) antagonist, 2-amino-5-phosphonovaleric acid (2-apv), on bicuculline-induced epileptogenesis in organotypic explant cultures from neonatal rat neocortex. explants were maintained in roller tubes for 3-5 weeks. the late, plateau phase of the intracellularly recorded paroxysmal depolarization shift was sensitive to both intracellularly injected hyperpolarizing currents and 2-apv, suggesting that this component is generated by a v ... | 1986 | 2877418 |
| non-haemagglutinating fimbriae of enteropathogenic escherichia coli (epec). | two hundred and thirteen escherichia coli strains originating in 12 countries were included in the study. of these, 157 were classical enteropathogenic e. coli (epec) serotypes, 54 belonged to o138, o139 and o141 serogroups i.e. porcine edema disease strains and two strains were of serogroup o157 associated with haemorrhagic colitis. surface hydrophobicity was determined by the salt aggregation test (sat). haemagglutination was assayed against erythrocytes of six animal species with strains grow ... | 1986 | 2876564 |
| [hismanal--a new nonsoporific hay fever medication]. | 2010 | 2876531 | |
| stimulant action of ethanol on posttetanic potentiation of hindlimb monosynaptic reflexes. | 1986 | 2876435 | |
| the ir-thy-1 concept: continuing saga. | 2010 | 2876044 | |
| 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (cheb): correlation of hypnotic and convulsant properties with alterations of synaptosomal 45ca2+ influx. | male icr mice (20-35 g) were given either 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (cheb) alone (10-15 mg/kg i.p.) or cheb (25-75 mg/kg i.p.) after a 1 h pretreatment with phenobarbital (75 mg/kg i.p.). cheb alone (10 mg/kg) produced excitatory behavior but not convulsive seizures. higher doses (11-15 mg/kg) produced convulsive seizures resulting in death. pretreatment with phenobarbital prevented seizure activity. following phenobarbital pretreatment, cheb in doses of 50 and 75, but n ... | 1986 | 2875881 |
| chronic treatment with iprindole reduces immobility of rats in the behavioural 'despair' test by activating dopaminergic mechanisms in the brain. | iprindole, 10 mg kg-1 i.p., once daily for 21 days, enhanced the metabolism of dopamine in the frontal cortex and striatum of rats with no effect in the nucleus accumbens 1 h after the last injection. noradrenaline metabolism in the brainstem and telencephalon was also increased in these conditions. no effect on dopamine or noradrenaline metabolism was seen 24 h after the last injection. the same repeated treatment schedule with iprindole markedly reduced the immobility of rats in the behavioura ... | 1986 | 2872301 |
| anxiolytic effects of progesterone are sexually dimorphic. | we evaluated the effects of progesterone administration to estrogen-primed rats on licking behavior during a lick suppression test. this test assesses the behavior of water-deprived rats to lick a drinking tube for water reinforcement that is paired to electric shock. chlordiazepoxide (a commonly used tranquilizer) is very effective in increasing licking during this test. normal females and neonatally castrated males displayed an increase in shock-punished responses in tests conducted after horm ... | 1986 | 2871472 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |
| pharmacokinetics of t-2 toxin and its metabolite ht-2 toxin, after intravenous administration in dogs. | the pharmacokinetics of t-2 toxin and ht-2 toxin were investigated comparatively in five dogs, after iv administration of the toxins (0.4 mg/kg). t-2 toxin was very rapidly and almost completely biotransformed to ht-2 toxin (fm = 83.6 +/- 3.9%). the following mean pharmacokinetic parameters were determined in this study for t-2 toxin and ht-2 toxin, respectively: half-life 5.3 +/- 2.1 and 19.6 +/- 4.7 min, clearance 0.107 +/- 0.056 and 0.167 +/- 0.074 liters/min/kg, and volume of distribution 0. ... | 1986 | 2870902 |