Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [biochemical and bacteriological investigation of six cases of purple urine bag syndrome (pubs) in a geriatric ward for dementia]. | purple urine bag syndrome is a condition in which the urinary catheter bag turns purple. a tryptophan-indigo hypothesis has been proposed as the mechanism of pubs, in which bacterial decomposition of tryptophan in gut associated with chronic constipation, bacterial overgrowth in the urinary tract and alkaline urine causes production of indigo and discoloration. we considered that further investigation of cases was needed. | 2008 | 19057104 |
| antimicrobial and antifungal activities of the extracts and essential oils of bidens tripartita. | the aim of this study was to determine the antibacterial and antifungal properties of the extracts, subextracts and essential oils of bidens tripartita flowers and herbs. in the study, twelve extracts and two essential oils were investigated for activity against different gram-positive bacillus subtilis, micrococcus luteus, staphylococcus aureus, gram-negative bacteria escherichia coli, e. coli (beta-laktamase+), klebsiella pneumoniae (esbl+), pseudomonas aeruginosa and some fungal organisms can ... | 2008 | 19056546 |
| ablation of sp-a has a negative impact on the susceptibility of mice to klebsiella pneumoniae infection after ozone exposure: sex differences. | surfactant protein a (sp-a) enhances phagocytosis of bacteria, including klebsiella pneumoniae, by alveolar macrophages. ozone, a major air pollutant, can cause oxidation of surfactant and may influence lung immune function. immune function may also be affected by sex-specific mechanisms. we hypothesized that ablation of sp-a has a negative impact on the susceptibility of mice to klebsiella pneumoniae infection after ozone exposure, and that sex differences in the effect of ozone do exist. | 2008 | 19055785 |
| endophytic occupation of peanut root nodules by opportunistic gammaproteobacteria. | several bacterial isolates were recovered from surface-sterilized root nodules of arachis hypogaea l. (peanut) plants growing in soils from córdoba, argentina. the 16s rdna sequences of seven fast-growing strains were obtained and the phylogenetic analysis showed that these isolates belonged to the phylum proteobacteria, class gammaproteobacteria, and included pseudomonas spp., enterobacter spp., and klebsiella spp. after storage, these strains became unable to induce nodule formation in arachis ... | 2009 | 19054642 |
| fe(iii) oxide reduction and carbon tetrachloride dechlorination by a newly isolated klebsiella pneumoniae strain l17. | to isolate an iron-reducing bacterium and examine its ability of fe(iii) oxide reduction and dechlorination. | 2009 | 19054230 |
| microbiological and toxicological effects of perla black bean (phaseolus vulgaris l.) extracts: in vitro and in vivo studies. | we investigated the microbiological and toxicological effects of three perla black bean extracts on the growth and culture of selected pathogenic microorganisms, the toxicity over vero cell lines and an in vivo rat model. three different solvents were used to obtain perla black bean extracts. all three perla black bean extracts were tested for antibacterial and antiparasitic activity and further analysed for intrinsic cytotoxicity (ic(50)). methanol perla black bean extract was used for acute to ... | 2009 | 19053992 |
| donovanosis with auto-amputation of penis in a hiv-2 infected person. | donovanosis is a slowly progressive, granulomatous ulcerative disease , caused by klebsiella (calymmatobacterium) granulomatis. the disease is known to persist for years together, leading to complications. a male patient aged 30 years with underlying hiv-2 infection presented to the department of std with painful ulceration over the genital region of 5 months duration, with absence of penis. tissue smear from the ulcer and histopathological examination revealed large histiocytes with intracellul ... | 2008 | 19052412 |
| multiplex pcr for bla(ctx-m) & bla(shv) in the extended spectrum beta lactamase (esbl) producing gram-negative isolates. | phenotyping is commonly used for detection of extended spectrum beta lactamase (esbl) production in gram-negative isolates. esbls are mainly coded for by three important genes, namely bla(tem), bla(shv) and bla(ctx-m). in this study we used a multiplex pcr as a rapid method to identify two common genes (bla(ctx-m) & bla(shv)) responsible for extended spectrum beta lactamase production in members of enterobacteriaceae family isolated from different clinical samples from a specialty hospital at ch ... | 2008 | 19052344 |
| phytochemical and comparative antibacterial studies on the crude ethanol and aqueous extracts of the leaves of lecaniodiscus cupanoides planch (sapindaceae). | phytochemical investigation was carried out on the leaves of lecaniodiscus cupanoides planch (sapindaceae). the diameter of the zones of inhibition of the 90% ethanol and aqueous extracts of the leaves were compared in order to determine the relative activity of the extracts against the tested microorganisms and also to verify its claimed ethnomedicinal use in the treatment of microbial infections. phytochemical tests were carried out employing standard procedures. the antimicrobial activity of ... | 2008 | 19051603 |
| synthesis and antimicrobial activity of some novel oxadiazole derivatives. | a series of 5-(3'-oxo-6'-(substituted aryl)-2',3',4',5'-tetrahydropyridazin-2'-ylmethyl )-2-substituted 1,3,4-oxadiazole has been synthesized. appropriate aromatic hydrocarbon reacts with succinic anhydride in the presence of aicl3 to yield beta-aroyl propionic acid (1a). the corresponding acid is cyclized with hydrazine hydrate to give 6-(substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinone (1b). this ntermediate after reaction with ethyl bromoacetate, was hydrazinolyzed into 3-oxo-6-(substitute ... | 2008 | 19051585 |
| [occurrence of ampc-positive klebsiella pneumoniae strains in patients with haematological malignancies]. | currently, important bacterial beta-lactamases of increasing clinical significance include ampc enzymes. the aim was to assess their occurrence in klebsiella pneumoniae strains isolated from patients with haematological malignancies in a prospective study. | 2008 | 19051165 |
| functional behaviour of polyethylene-zno nanocomposites. | hybrid inorganic-organic nanocomposite materials are of current interest because of their multifunctionality, ease of processability, and potential for large-scale manufacturing. the focus of this study is to ascertain the functional properties of the commodity plastic impregnated with zno/starch nanocomposites. zno/starch nanocomposites was prepared by a simple process using zinc nitrate and sodium hydroxide as precursor and soluble starch as stabilizing agent. the peak obtained in terms of wav ... | 2008 | 19049187 |
| capsule polysaccharide is a bacterial decoy for antimicrobial peptides. | antimicrobial peptides (aps) are important host weapons against infections. nearly all aps are cationic and their microbicidal action is initiated through interactions with the anionic bacterial surface. it is known that pathogens have developed countermeasures to resist these agents by reducing the negative charge of membranes, by active efflux and by proteolytic degradation. here we uncover a new strategy of resistance based on the neutralization of the bactericidal activity of aps by anionic ... | 2008 | 19047754 |
| a case of haemoptysis. | 2008 | 19046714 | |
| hyperammonemic encephalopathy caused by urinary tract infection with urinary retention. | 2008 | 19046708 | |
| [antagonistic properties of enterococci isolated from gastrointestinal tract of long-livers]. | the strains with antagonistic activity against indicator strains pseudomonas aeruginosa, proteus vulgaris, staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella pneumonia, salmonella enterica were revealed among 58 enterococcus strains isolated from gastrointestinal tract of long-livers. the influence of different components of mrs medium on the antagonistic effect was established. antagonistic activity remained on the medium without glucose in 36% of strains, on the me ... | 2008 | 19044009 |
| the major surface-associated saccharides of klebsiella pneumoniae contribute to host cell association. | analysing the pathogenic mechanisms of a bacterium requires an understanding of the composition of the bacterial cell surface. the bacterial surface provides the first barrier against innate immune mechanisms as well as mediating attachment to cells/surfaces to resist clearance. we utilised a series of klebsiella pneumoniae mutants in which the two major polysaccharide layers, capsule and lipopolysaccharide (lps), were absent or truncated, to investigate the ability of these layers to protect ag ... | 2008 | 19043570 |
| colonization of the respiratory tract by drug-resistant bacteria in hiv-infected children and prior exposure to antimicrobials. | the aim of this short communication is to assess colonization by mrsa, penicillin-resistant pneumococci (prp), fluconazole-resistant (flu-r) candida albicans (ca) and non-albicans candida (nac), and ciprofloxacin-resistant e. coli with regard to immune recovery due to cd4 t-cell increase depending on the duration of highly active antiretroviral therapy (haart). prior exposure to oral cephalosporins (p<0.01) was significantly related to mrsa colonization. penicillin-resistant pneumococci were mor ... | 2008 | 19043382 |
| evaluation of chromagar ctx, a novel medium for isolating ctx-m-esbl-positive enterobacteriaceae while inhibiting ampc-producing strains. | the aim of this study was to evaluate chromagar ctx (chromagar france), a novel agar for the selective isolation of enterobacteriaceae expressing the bla(ctx-m) gene in the presence of enteric bacteria expressing ampc enzymes. | 2009 | 19043079 |
| in situ recovery of 2,3-butanediol from fermentation by liquid-liquid extraction. | end-product conversion, low product concentration and large volumes of fermentation broth, the requirements for large bioreactors, in addition to the high cost involved in generating the steam required to distil fermentation products from the broth largely contributed to the decline in fermentative products. these considerations have motivated the study of organic extractants as a means to remove the product during fermentation and minimize downstream recovery. the aim of this study is to assess ... | 2009 | 19037672 |
| ertapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia. | imipenem and meropenem are treatment of choice for extended-spectrum betalactamase (esbl)-positive gram-negative bacteraemia. they may select for carbapenemresistant acinetobacter baumannii and pseudomonas aeruginosa; ertapenem may not do so as it is inactive against these bacteria. clinical efficacy of ertapenem in esbl-producing gramnegative bacteraemia is limited. | 2008 | 19037516 |
| antibiotic resistance in gram-negative bacilli: a singapore perspective. | antibiotic resistance in gram-negative bacilli is an area of increasing importance. this prospective study was performed to survey antibiotic resistance in escherichia coli (e. coli), klebsiella spp., pseudomonas aeruginosa and acinetobacter spp. over a 1-year period. | 2008 | 19037514 |
| identification of plasmid-mediated ampc beta-lactamases in escherichia coli, klebsiella spp., and proteus species can potentially improve reporting of cephalosporin susceptibility testing results. | the goal of this study was to determine if the interpretations of extended-spectrum and advanced-spectrum cephalosporins (escs and ascs, respectively) for isolates of enterobacteriaceae would be impacted by the results of aminophenylboronic acid (apba) testing. fifty-three isolates of escherichia coli, 21 klebsiella species, and 6 proteus species that were resistant to at least one esc were tested by disk diffusion with ceftazidime and cefotetan disks with and without apba. ceftazidime disks wit ... | 2009 | 19036936 |
| development and evaluation of a real-time pcr assay for detection of klebsiella pneumoniae carbapenemase genes. | we developed a novel real-time pcr assay to detect klebsiella pneumoniae carbapenemases (kpcs) and used this assay to screen clinical isolates of k. pneumoniae and klebsiella oxytoca for the presence of bla(kpc) genes. the taqman real-time pcr assay amplified a 399-bp product from the bla(kpc) gene. the amplicon was designed so that the genes for isoenzymes kpc-1, -2, and -3 could be easily distinguished by subsequent restriction digestion of the amplicon with the enzymes bstni and rsai. the ass ... | 2009 | 19036932 |
| the klebsiella pneumoniae o2a antigen defines a second mechanism for o antigen atp-binding cassette transporters. | an atp-binding cassette (abc) transporter-dependent mechanism is responsible for the biosynthesis of polysaccharide o antigens in the lipopolysaccharides of many gram-negative bacteria. in the escherichia coli o9a prototype, addition of a non-reducing terminal modification regulates chain length. the terminal residue is an export signal recognized by the nucleotide-binding domain component of the cognate abc transporter. the klebsiella pneumoniae o2a antigen lacks a capping residue, and the corr ... | 2009 | 19036729 |
| one-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity. | we here report the synthesis and biological evaluation of rare 4-substituted-5-phenylimino, 5-thieno- and 5-oxo-1,2,3-dithiazoles. dithiazoles were selectively obtained in moderate to high yields (25-73%) via a one-pot reaction from various ethanoneoximes with sulfur monochloride, pyridine in acetonitrile followed by treatment by corresponding nucleophiles (aniline, thioacetamide and formic acid). all the synthesized compounds were screened for their antibacterial (against bacteria escherichia c ... | 2009 | 19036587 |
| beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat. | although citrulline malate (cm; cas 54940-97-5, stimol) is used against fatigue states, its anti-asthenic effect remains poorly documented. the objective of this double-blind study was to evaluate the effect of oral ingestion of cm on a rat model of asthenia, using in situ (31)phosphorus magnetic resonance spectroscopy ((31)p-mrs). muscle weakness was induced by intraperitoneal injections of klebsiella pneumoniae endotoxin (lipopolysaccharides at 3 mg/kg) at t(0) and t(0)+24 h. for each animal, ... | 2009 | 19036344 |
| clinical and pulmonary thin-section ct findings in acute klebsiella pneumoniae pneumonia. | the aim of this study was to assess the clinical and pulmonary thin-section ct findings in patients with acute klebsiella pneumoniae pneumonia. we retrospectively evaluated thin-section ct examinations performed between january 1991 and december 2007 from 962 patients with acute klebsiella pneumoniae pneumonia. seven hundred and sixty-four cases with concurrent infectious diseases were excluded. thus, our study group comprised 198 patients (118 male, 80 female; age range 18-97 years, mean age 61 ... | 2009 | 19034459 |
| impact of restriction of third generation cephalosporins on the burden of third generation cephalosporin resistant k. pneumoniae and e. coli in an icu. | to test whether a reduction of third generation cephalosporin (3gc) use has a sustainable positive impact on the high endemic prevalence of 3gc resistant k. pneumoniae and e. coli. | 2009 | 19034426 |
| ctx-m expression and selection of ertapenem resistance in klebsiella pneumoniae and escherichia coli. | in vitro selection of mutants with decreased susceptibility to ertapenem was performed using escherichia coli and klebsiella pneumoniae clinical strains producing either the bla(ctx-m-2), bla(ctx-m-3), bla(ctx-m-9), or bla(ctx-m-15) gene. frequencies of mutants with decreased susceptibilities to ertapenem were similar for all beta-lactamases expressed. | 2009 | 19029330 |
| first report on a hyperepidemic clone of kpc-3-producing klebsiella pneumoniae in israel genetically related to a strain causing outbreaks in the united states. | a highly epidemic carbapenem-resistant clone of kpc-3-producing klebsiella pneumoniae emerged in israel in 2006, causing a nationwide outbreak. this clone was genetically related to outbreak strains from the united states isolated in 2000 but differed in kpc-carrying plasmids. the threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted. | 2009 | 19029323 |
| carbapenem-hydrolysing beta-lactamase kpc-2 in klebsiella pneumoniae isolated in rio de janeiro, brazil. | the aim of this study was to characterize the kpc-type carbapenem-hydrolysing beta-lactamase, extended-spectrum beta-lactamases (esbls) and class 1 integrons among nosocomial klebsiella pneumoniae isolated in rio de janeiro, brazil. | 2009 | 19028717 |
| effect of clarithromycin on lung inflammation and alveolar macrophage function in klebsiella penumoniae b5055-induced acute lung infection in balb/c mice. | acute lung injuries due to acute lung infections remain the major cause of mortality. thus antibiotics with immunomodulatory and anti-inflammatory activities ,regardless of their antibacterial properties, will help to overcome acute lung infection-induced injuries. the macrolide antibiotics have been shown to possess these properties. clarithromycin has been shown to possess anti-inflammatory properties in chronic inflammatory conditions. so we evaluated the anti-inflammatory effect of clarithro ... | 2008 | 19028625 |
| prevalence and genetic characterization of blactx-m among klebsiella pneumoniae isolates collected in an intensive care unit in brazil. | thirteen (44.8%) ctx-m-2-producing k. pneumoniae clinical isolates were identified among 29 strains collected from single patients with serious infection hospitalized in an intensive care unit of a tertiary hospital located in são paulo, brazil. these isolates belonged to 9 different typing clusters and showed great diversity of plasmid content. their bla(ctx-m-2)was carried in an iscr1/sul1-type integron structure located in transferable plasmids of different sizes or in the chromosome. | 2008 | 19028623 |
| nosocomial spread of arma-mediated high-level aminoglycoside resistance in enterobacteriaceae isolates producing ctx-m-3 beta-lactamase in a cancer hospital in bulgaria. | 1,310 enterobacteriaceae, 242 pseudomonas aeruginosa and 97 acinetobacter baumannii clinical isolates collected at a cancer hospital in bulgaria were screened for the presence of 16s rrna methylases. the arma methylase gene was identified in 20 (1.5%) enterobacteriaceae (7 klebsiella pneumoniae, 3 escherichia coli, 3 serratia marcescens, 3 citrobacter freundii , 3 enterobacter cloacae and 1 klebsiella oxytoca). arma-mediated aminoglycoside resistance was transferable by conjugation and carried b ... | 2008 | 19028622 |
| risk factors in community-acquired/onset urinary tract infections due to extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae. | we investigated the risk factors for community acquired/onset urinary tract infections due to extended spectrum beta-lactamase (esbl)-positive escherichia coli or klebsiella pneumoniae in 62 patients who were followed-up from august 1, 2003 to september 1, 2006. sixty patients with community-acquired urinary tract infections caused by esbl-negative e. coli or k. pneumoniae who were followed-up during the same dates were included as a control group. age (> or =65 or <65 years old), sex, bladder c ... | 2008 | 19028620 |
| in vitro activity of tigecycline: mics, mbcs, time-kill curves and post-antibiotic effect. | the minimum inhibitory concentrations (mics), minimum bactericidal concentrations (mbcs), time-kill curves, and postantibiotic effect (pae) of tigecycline, the first in the glycylcycline class of antibiotics, were evaluated. mics were determined against 749 clinical isolates. time-kill curves were performed against two isolates each of enterococcus faecalis, mssa, and mrsa. the presence of pae, against the same isolates, was investigated. mic(90)s (microg/ml) were the following: escherichia coli ... | 2008 | 19028619 |
| antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in italy. | in this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical italian microbiology laboratories. on penicillin-susceptible pneumococci and streptococcus pyogenes, cefditoren demonstrated to be the most active antibiotic (mic(90)values of 0.03 and 0.06 mg/l respectively), showing only a slight decrease in potency on penic ... | 2008 | 19028617 |
| mrkf is a component of type 3 fimbriae in klebsiella pneumoniae. | klebsiella pneumoniae type 3 fimbriae are encoded by mrkabcdf genes which produce the major pilin subunit mrka, chaperone mrkb, outer membrane usher mrkc, adhesin mrkd and mrkf of unknown function, respectively. rt-pcr analysis demonstrated that the mrkf gene is contained within the mrk operon. deletion of mrkf in k. pneumoniae cg43 was found to reduce biofilm formation. a higher level of biofilm formation activity was also observed in recombinant escherichia coli jm109[pmrkabcdf] compared to th ... | 2009 | 19028568 |
| insertion sequences in the is1111 family that target the attc recombination sites of integron-associated gene cassettes. | members of the recently identified is1111 family differ from the majority of insertion sequences (is) in that they target specific sites in an orientation-specific manner. however, the way in which target selection is achieved is not known. iskpn4 is representative of a new subgroup of the is1111 family whose members are found in the attc sites (59-be) of the gene cassettes associated with integrons. the transposases of this subgroup are closely related (over 75% identity), confirming that close ... | 2009 | 19025573 |
| impact of enhanced infection control at 2 neonatal intensive care units in the philippines. | the growing burden of neonatal mortality associated with hospital-acquired neonatal sepsis in the developing world creates an urgent need for cost-effective infection-control measures in resource-limited settings. | 2009 | 19025496 |
| [nationwide susceptibility surveillance of ciprofloxacin and various parenteral antimicrobials against bacteria isolated from patients with severe infections--third ciproxan injection special survey (2005)]. | we conducted 3 nationwide surveillance studies between 2001 and 2005 at 39 participating institutions throughout japan according to the special survey plan to investigate susceptibility to ciprofloxacin (cpfx) and various parenteral antimicrobials using clinical isolates from patients with severe infection during the reexamination period of parenteral cpfx. results of the first special survey (2001) were already reported in this journal. the current third special survey (2005) was conducted at 3 ... | 2008 | 19024645 |
| [susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (2005)]. | from october 2005 to september 2006, we collected the specimen from 366 patients with lower respiratory tract infections in 12 institutions in japan, and investigated the susceptibilities of isolated bacteria to various antibacterial agents and patients' characteristics. of 411 strains that were isolated from specimen (mainly from sputum) and assumed to be bacteria causing in infection, 406 strains were examined. the isolated bacteria were: staphylococcus aureus 70, streptococcus pneumoniae 85, ... | 2008 | 19024644 |
| [a case of klebsiella pneumoniae outbreak in a newborn intensive care unit]. | to investigate and take a case study on a klebsiella pneumoniae outbreak in a newborn intensive care unit (nicu). | 2008 | 19024381 |
| antibacterial activity of acalypha indica l. | hexane, chloroform, ethyl acetate and methanol extracts from the leaves of acalypha indica were tested against gram-positive (staphylococcus aureus, staphylococcus epidermidis, bacillus cereus, streptococcus faecalis) and gram-negative (klebsiella pneumoniae, escherichia coli, proteus vulgaris, pseudomonas aeruginosa) bacteria. all the extracts exhibited antibacterial activity against gram-positive organisms with minimum inhibitory concentrations (mic) between 0.156 to 2.5 mg/ml. among the gram- ... | 2008 | 19024213 |
| aerobic vaginal pathogens and their sensitivity pattern. | the vaginal flora is a complicated environment, containing dozens of microbiological species in variable quantities and relative proportions. the frequent cause of vaginal discharge is an infection or colonization with different microorganisms. some pathologic conditions causing vaginitis are well defined yet, 7-72% of women with vaginitis may remain undiagnosed and such forms of abnormal vaginal flora neither considered as normal, nor can be called bacterial vaginosis have been termed as 'inter ... | 2008 | 19024202 |
| frequency of renal stone disease in patients with urinary tract infection. | to determine incidence of renal stone disease in patients with urinary tract infection, this cross sectional study was conducted at surgical unit of district head quarters hospital, charsadda over a period of one year from january to december 2005. | 2008 | 19024188 |
| bacterial contamination in drinking water: a case study in rural areas of northern rajasthan, india. | the objective of this study was to determine the bacterial contaminations in drinking water samples collected form some rural habitations of northern rajasthan, india. a total of ten bacterial species: escherichia coli, pseudomonas aeruginosa, enterobacter aerogenes, klebsiella sp, proteus vulgaris, alcaligenes faecalis, bacillus cereus, staphylococcus aureus, streptococcus lactis and micrococcus luteum were identified form drinking water samples. the bacteria belonging to the family enterobacte ... | 2009 | 19023670 |
| pyogenic portal vein thrombosis as a reservoir of persistent septicemia after cyanoacrylate injection for bleeding gastric varices. | gastric variceal bleeding is a serious complication of liver cirrhosis. a recent consensus suggested that endoscopic injection of tissue glue for gastric variceal obliteration (gvo) should be the first choice for treatment of acute gastric variceal bleeding. following the widespread use of gvo, more severe complications such as needle cementation, fistula formation, embolic sequels, recurrent septicemia, etc., have been reported. we present the first case of gvo-complicated pyogenic portosplenic ... | 2008 | 19023208 |
| increasing prevalence of esbl-producing enterobacteriaceae in europe. | extended-spectrum beta-lactamases (esbls) have been increasingly reported in europe since their first description in 1983. during the 1990s, they were described mainly as members of the tem- and shv-beta-lactamase families in klebsiella pneumoniae causing nosocomial outbreaks. nowadays, they are mostly found in escherichia coli that cause community-acquired infections and with increasing frequency contain ctx-m enzymes. dissemination of specific clones or clonal groups and epidemic plasmids in c ... | 2008 | 19021958 |
| emergence of extensively drug-resistant and pandrug-resistant gram-negative bacilli in europe. | international and local surveillance networks as well as numerous reports in the biomedical literature provide evidence that the prevalence of antibiotic resistant gram-negative bacteria is escalating in many european countries. furthermore, isolates characterised as multidrug-resistant (i.e. resistant to three or more classes of antimicrobials), extensively drug resistant (i.e. resistant to all but one or two classes) or pandrug-resistant (i.e. resistant to all available classes) are increasing ... | 2008 | 19021957 |
| bacterial aetiology and outcome in children with severe pneumonia in uganda. | pneumonia is a major cause of morbidity and mortality in the 'under-5s' and in uganda accounts for 10-30% of childhood deaths. antibiotic resistance is increasing. | 2008 | 19021940 |
| a klebsiella pneumoniae sputum culture isolate from china carrying blaoxa-1, blactx-m-55 and aac(6')-ib-cr. | 2008 | 19018035 | |
| therapeutic potential of bacteriophage in treating klebsiella pneumoniae b5055-mediated lobar pneumonia in mice. | klebsiella pneumoniae causes infections in humans especially in immunocompromised patients. about 80 % of nosocomial infections caused by k. pneumoniae are due to multidrug-resistant strains. the emergence of antibiotic-resistant bacterial strains necessitates the exploration of alternative antibacterial therapies, which led our group to study the ability of bacterial viruses (known as bacteriophages or simply phages) to treat mice challenged with k. pneumoniae. phage ss specific for k. pneumoni ... | 2008 | 19018021 |
| towards understanding the nitrogen signal transduction for nif gene expression in klebsiella pneumoniae. | in the diazotroph klebsiella pneumoniae, the nitrogen sensory protein glnk mediates the cellular nitrogen status towards the nifl/nifa system that regulates transcription of the nitrogen fixation genes in response to ammonium and molecular oxygen. to identify amino acids of glnk essential for this signal transduction by protein-protein interaction, we performed random point mutagenesis by pcr amplification under conditions of reduced taq polymerase fidelity. three thousand two hundred mutated gl ... | 2008 | 19016838 |
| klebsiella pneumoniae ompa confers resistance to antimicrobial peptides. | a klebsiella pneumoniae ompa mutant was more susceptible to antimicrobial peptides (aps) than the wild type. susceptibility did not result from surface changes other than the absence of ompa. our data suggest that ompa is implicated in the activation of yet-unknown systems dedicated to ameliorating ap cytotoxicity. | 2009 | 19015361 |
| characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from escherichia coli, klebsiella pneumoniae, and proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. | in concert with the development of novel beta-lactams and broad-spectrum cephalosporins, bacterially encoded beta-lactamases have evolved to accommodate the new agents. this study was designed to identify, at the sequence level, the genes responsible for the extended-spectrum-beta-lactamase (esbl) phenotypes of escherichia coli, klebsiella pneumoniae, and proteus mirabilis isolates collected during the global tigecycline phase 3 clinical trials. pcr assays were developed to identify and clone th ... | 2009 | 19015360 |
| phenotypic and enzymatic comparative analysis of the novel kpc variant kpc-5 and its evolutionary variants, kpc-2 and kpc-4. | a novel klebsiella pneumoniae carbapenemase (kpc) variant, designated bla(kpc-5), was discovered in a carbapenem-resistant pseudomonas aeruginosa clinical isolate from puerto rico. characterization of the upstream region of bla(kpc-5) showed significant differences from the flanking regions of other bla(kpc) variants. comparison of amino acid sequences with those of other kpc enzymes revealed that kpc-5 was an intermediate between kpc-2 and kpc-4, differing from kpc-2 by a single amino acid subs ... | 2009 | 19015357 |
| first report of kpc-2-producing klebsiella pneumoniae strains in brazil. | 2009 | 19015350 | |
| klebsiella pneumoniae increases the levels of toll-like receptors 2 and 4 in human airway epithelial cells. | airway epithelial cells act as the first barrier against pathogens. these cells recognize conserved structural motifs expressed by microbial pathogens via toll-like receptors (tlrs) expressed on the surface. in contrast to the level of expression in lymphoid cells, the level of expression of tlr2 and tlr4 in airway epithelial cells is low under physiological conditions. here we explored whether klebsiella pneumoniae upregulates the expression of tlrs in human airway epithelial cells. we found th ... | 2009 | 19015258 |
| humoral immunity against capsule polysaccharide protects the host from maga+ klebsiella pneumoniae-induced lethal disease by evading toll-like receptor 4 signaling. | klebsiella pneumoniae maga (for mucoviscosity-associated gene a) is linked to the pathogenesis of primary pyogenic liver abscess, but the underlying mechanism by which maga increases pathogenicity is not well elucidated. in this study, we investigated the role of the capsular polysaccharides (cps) in the pathogenesis of maga(+) k. pneumoniae by comparing host immunity to maga(+) k. pneumoniae and a deltamaga mutant. we found that toll-like receptor 4 recognition by maga(+) k. pneumoniae was hamp ... | 2009 | 19015249 |
| a klebsiella pneumoniae clinical isolate producing the lap-2 beta-lactamase in china. | 2009 | 19013676 | |
| nationwide surveillance in taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum beta-lactamase-producing enterobacteriaceae. | tigecycline in-vitro surveillance in taiwan (tist), initiated in 2006, is a nationwide surveillance programme designed to monitor longitudinally the in-vitro activity of tigecycline against commonly encountered resistant bacteria. this study compared the in-vitro activity of tigecycline against clinical isolates of resistant gram-negative bacteria determined by the broth microdilution and etest methods. a total of 622 isolates were collected from patients treated at 20 teaching hospitals. tigecy ... | 2008 | 19013351 |
| antimicrobial drug resistance in taiwan. | antimicrobial resistance is a major health problem worldwide, but marked variations in the resistance profiles of bacterial pathogens are found between countries and in different patient settings, especially in asia. in taiwan, the strikingly high prevalence of resistance to macrolides and streptogramins in clinical isolates of gram-positive bacteria correlates with the widespread use of these agents in the medical and farming communities. the relatively low proportion of enterococci that are re ... | 2008 | 19013350 |
| 1,3-propanediol dehydrogenase from klebsiella pneumoniae: decameric quaternary structure and possible subunit cooperativity. | klebsiella pneumoniae is a nosocomial pathogen frequently isolated from opportunistic infections, especially in clinical environments. in spite of its potential pathogenicity, this microorganism has several metabolic potentials that could be used in biotechnology applications. k. pneumoniae is able to metabolize glycerol as a sole source of carbon and energy. 1,3-propanediol dehydrogenase is the core of the metabolic pathway for the use of glycerol. we have determined the crystallographic struct ... | 2009 | 19011020 |
| functional nanoparticle-based proteomic strategies for characterization of pathogenic bacteria. | although matrix-assisted laser desorption/ionization mass spectrometry (maldi ms) can be employed to rapidly characterize pathogenic bacteria, bacterial cultures are generally required to obtain sufficient quantities of the bacterial cells prior to maldi ms analysis. if this time-consuming step could be eliminated, the length of time required for identification of bacterial strains would be greatly reduced. in this paper, we propose an effective means of rapidly identifying bacteria--one that do ... | 2008 | 19007241 |
| a new high-alkaline alginate lyase from a deep-sea bacterium agarivorans sp. | a high-alkaline, salt-activated alginate lyase is produced by agarivorans sp. jam-a1m from a deep-sea sediment off cape nomamisaki on kyushu island, japan. purified to homogeneity, as judged by sds-page, the enzyme (a1m) had a molecular mass of approximately 31 kda. the optimal ph was around 10 in glycine-naoh buffer, and the activity was increased to 1.8 times by adding 0.2 m nacl. however, when the optimal ph in the presence of 0.2 m nacl was shifted to ph 9.0, the activity was more than 10 ti ... | 2009 | 19002649 |
| locked nucleic acid pentamers as universal pcr primers for genomic dna amplification. | multiplexing technologies, which allow for simultaneous detection of multiple nucleic acid sequences in a single reaction, can save a lot of time, cost and labor compared to traditional single reaction detection methods. however, the multiplexing method currently used requires precise handiwork and many complicated steps, making a new, simpler technique desirable. oligonucleotides containing locked nucleic acid residues are an attractive tool because they have strong affinities for their complem ... | 2008 | 19002243 |
| a fatal metastasis of klebsiella pneumoniae to the lungs. | to describe the relationship between a seemingly innocuous colonization in one organ and a fatal infection in another organ in a tetraplegic man. | 2009 | 19002149 |
| [analysis of antibiotic consumption and microorganism resistance changes]. | summary objective: the main goal of this study was to evaluate the variation of antibiotic consumption and relation between antibiotic consumption and microorganism resistance. | 2008 | 19001833 |
| protective efficacy of emblica officinalis against klebsiella pneumoniae induced pneumonia in mice. | emblica officinalis (amla), which is a good source of vitamin c, has been shown to be beneficial due to its immune system enhancing property coupled with its tonifying and antiageing effect. the present study was conducted to evaluate the effect of e. officinalis feeding on the susceptibility of experimental mice to respiratory tract infection induced by klebsiella pneumoniae. | 2008 | 19001683 |
| a study on nosocomial pathogens in icu with special reference to multiresistant acinetobacter baumannii harbouring multiple plasmids. | antibiotic resistant bacterial nosocomial infections are a leading problem in intensive care units (icu). present investigation was undertaken to know antibiotic resistance in acinetobacter baumannii and some other pathogens obtained from clinical samples from icu causing nosocomial infections. special emphasis was given on plasmid mediated transferable antibiotic resistance in acinetobacter. | 2008 | 19001682 |
| nationwide survey of ctx-m-type extended-spectrum beta-lactamases among klebsiella pneumoniae isolates in slovenian hospitals. | among 177 extended-spectrum beta-lactamase-producing klebsiella pneumoniae isolates collected from 11 slovenian hospitals in 2005 and 2006, 60 (34%), from eight hospitals, harbored genes for ctx-m enzymes, with bla(ctx-m-15) detected by sequencing. these 60 isolates comprised 11 pulsed-field gel electrophoresis-defined strains, with several clusters of closely related isolates. plasmids encoding ctx-m-15 enzyme were highly transmissible. | 2009 | 19001116 |
| physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde. | a series of novel macrocyclic compounds were synthesized by the condensation of o-phthalaldehyde with aromatic amino alcohols followed by treatment with 1,2-dibromoethane or 1,3-dibromopropane in non-template method. the structural features of the isolated macrocycles have been determined from the microanalytical, ir, (1)h, (13)c nmr and mass spectral studies. antimicrobial activities of these macrocyclic compounds were tested against the gram-positive (bacillus subtilis, staphylococcus aureus) ... | 2009 | 18996622 |
| the bioactivity of novel furanoterpenoids isolated from siphonochilus aethiopicus. | this study investigated the medicinal plant siphonochilus aethiopicus (zingiberaceae) for antiplasmodial activity. | 2009 | 18996179 |
| comparative in vitro activity of tigecycline and other antimicrobials against gram-negative and gram-positive organisms collected from the asia-pacific rim as part of the tigecycline evaluation and surveillance trial (test). | as part of the tigecycline evaluation and surveillance trial (test), gram-negative and gram-positive organisms were collected from 31 medical centres in nine countries in the asia-pacific rim between 2004 and 2007. overall, 34.2% of acinetobacter spp. were multidrug-resistant, and 17.0% of klebsiella pneumoniae and 10.6% of escherichia coli produced extended-spectrum beta-lactamases. a total of 39.5% of staphylococcus aureus were meticillin-resistant and 21.7% of enterococcus faecium were vancom ... | 2009 | 18995992 |
| atypical mycobacteriosis of the larynx: an unusual clinical presentation secondary to steroids inhalation. | vocal cords stiffness can be associated with a variety of etiologic agents, but it is rarely seen with atypical mycobacteria, for example, mycobacterium avium complex. we report a case of a 35-year-old white woman who is and was maintained on inhaled steroids. she presented with hoarseness and low-grade fever, but her medical history was otherwise unremarkable. laryngoscopy revealed bilateral scarring of the vocal cords. vocal cord biopsies were performed. histologic examination revealed unremar ... | 2008 | 18995207 |
| detection and genetic characterisation of qnrb in hospital isolates of klebsiella pneumoniae in singapore. | polymerase chain reaction (pcr) screening of 116 ciprofloxacin-resistant klebsiella pneumoniae hospital isolates for the presence of qnr genes that mediate plasmid quinolone resistance revealed that none were positive for qnra or qnrs. however, qnrb was detected in ca. 5.2% of the isolates. southern hybridisation demonstrated that the qnrb-hybridising plasmids were large (>70kb) and capable of transferring quinolone resistance by conjugation. sequence analysis of the qnrb genes detected in this ... | 2009 | 18993034 |
| klebsiella pneumoniae liver abscess: an emerging problem in north america. | background: before the 1980s, escherichia coli was the most common cause of pyogenic liver abscess, but more recently, klebsiella pneumoniae has emerged as the most common organism in the united states and taiwan. objective: our goal is to present a case of k. pneumoniae liver abscess (kla) and review the risk factors, presenting symptoms, complications, and treatment of this disease that is emerging in north america. case report: we present a patient who was found to have kla complicated by bac ... | 2008 | 18993020 |
| emphysematous cystitis: a rare cause of gross hematuria. | emphysematous cystitis is a relatively rare infectious condition of the urinary bladder. the mortality rate is high if the diagnosis is delayed or if the treatment is inadequate. we present an uncommon case of emphysematous cystitis and highlight the risk factors for this disease. an 81-year-old man with a past medical history of type 2 diabetes and a central pontine infarction presented to the emergency department due to gross hematuria. computed tomography (ct) and plain radiography revealed l ... | 2011 | 18993014 |
| dissemination of bla(imp-1)-carrying integron in86 among klebsiella pneumoniae isolates harboring a new trimethoprim resistance gene dfr23. | the genetic context of the bla(imp-1) gene was evaluated in 9 klebsiella pneumoniae isolates recovered from 2 hospitals in são paulo, brazil. all isolates harbored a copy of in86 carrying bla(imp-1), aac(6')-31, and aada1. eight strains from the same hospital also carried another class 1 integron harboring a new trimethoprim resistance gene (dfr23) that was chromosomally embedded. in86 was likely to be in a 30-kb nontransferable plasmid and was flanked upstream by a sequence identical to one ide ... | 2009 | 18990526 |
| characterization of plasmids encoding blaesbl and surrounding genes in spanish clinical isolates of escherichia coli and klebsiella pneumoniae. | the aim of the study was to characterize plasmids that harbour blaesbl genes and their genetic environment in escherichia coli and klebsiella pneumoniae clones circulating in spain. | 2009 | 18988679 |
| the effect of limiting antimicrobial therapy duration on antimicrobial resistance in the critical care setting. | using antimicrobial agents for prolonged periods of time and/or in heavy densities is known to contribute to antimicrobial resistance. | 2009 | 18986735 |
| the evolution of drug-resistant microorganisms in patients with prolonged mechanical ventilation. | patients requiring prolonged mechanical ventilation (pmv) tend to become reservoirs of antimicrobial resistance. we assessed antimicrobial-resistant microorganisms in the respiratory tracts of patients receiving pmv. | 2009 | 18986734 |
| spectrum of organisms causing peritonitis in peritoneal dialysis patients--experience from bangladesh. | in the present study, organisms responsible for peritonitis and their sensitivity to antibiotics were evaluated in peritoneal dialysis (pd) patients in bangladesh. we collected pd effluent from 100 peritonitis cases and sent samples to the laboratory for gram stain and cytology. cultures used direct inoculation of pd fluid in plate media and broth media simultaneously. organisms were isolated by gram stain in 60% of cases. cell counts showed a mean of 700 (range: 90-7000) white blood cells per m ... | 2008 | 18985999 |
| antimicrobial susceptibility pattern of microorganisms involved in the pathogenesis of surgical site infection (ssi); a 1 year of surveillance. | the aim of this study is to identify the antibiotic sensitivity pattern of pathogens involved in the process of surgical site infection, in surgical wards. changes made in the pattern of antibiotic use will result in different microorganism susceptibility patterns, which needs correct determination for precise empiric antibiotic therapy. one thousand patients (62% men and 38% women, 18- 74-years-old, with mean age 43 +/- 8)) who underwent surgical treatment, in alzahra university hospital, isfah ... | 2008 | 18983037 |
| bacteriology of non-surgical wound infections in ibadan, nigeria. | previous studies done on wound infections in this environment had been mostly on the surgical variety rather than the non-surgical. however,few studies available on the non-surgical type have indicated that changes do occur in the pattern and antibiogram of the bacterial isolates of these non-surgical wound infections. this study was therefore designed to investigate the bacteriology of non-surgical wound infections in this environment. a retrospective review of seven hundred and fifty four case ... | 2008 | 18982819 |
| management of nosocomial external ventricular drain-related ventriculomeningitis. | introduction: neurocritical care patients requiring external ventricular drainage are at risk for the development of a device-related infection. infection rate of external ventriculostomy catheters is high with reported incidences ranging from 5% up to more than 20%. nosocomial ventriculitis or ventriculomeningitis are potential life-threatening conditions which may contribute to a permanent adverse outcome of the patient. reducing morbidity and mortality is strongly dependent on prompt diagnosi ... | 2009 | 18982457 |
| beta2-microglobulin-dependent bacterial clearance and survival during murine klebsiella pneumoniae bacteremia. | klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative bacterial pneumonia. a significant clinical complication of klebsiella pulmonary infections is peripheral blood dissemination, resulting in a systemic infection concurrent with the localized pulmonary infection. we report here on the critical importance of beta(2)-microglobulin expression during murine k. pneumoniae bacteremia. beta(2)-microglobulin knockout mice displayed significantly increased mor ... | 2009 | 18981251 |
| role of human cd36 in bacterial recognition, phagocytosis, and pathogen-induced jnk-mediated signaling. | scavenger receptor cd36 mediates staphylococcus aureus phagocytosis and initiates tlr2/6 signaling. we analyzed the role of cd36 in the uptake and tlr-independent signaling of various bacterium, including escherichia coli, klebsiella pneumoniae, salmonella typhimurium, s. aureus, and enterococcus faecalis. expression of human cd36 in hela cells increased the uptake of both gram-positive and gram-negative bacteria compared with the control mock-transfected cells. bacterial adhesion was associated ... | 2008 | 18981136 |
| type ii secretion system secretin puld localizes in clusters in the escherichia coli outer membrane. | the cellular localization of a chimera formed by fusing a monomeric red fluorescent protein to the c terminus of the klebsiella oxytoca type ii secretion system outer membrane secretin puld (puld-mcherry) in escherichia coli was determined in vivo by fluorescence microscopy. like puld, puld-mcherry formed sodium dodecyl sulfate- and heat-resistant multimers and was functional in pullulanase secretion. chromosome-encoded puld-mcherry formed fluorescent foci on the periphery of the cell in the pre ... | 2009 | 18978053 |
| time-dependent effects of klebsiella pneumoniae endotoxin on the telithromycin pharmacokinetics in rats; restoration of the parameters in 96-hour kplps rats to the control levels. | it has been reported that telithromycin is primarily metabolized via hepatic cyp3a4 and 3a1/2 in humans and rats, respectively, and that the protein expression of hepatic cyp3a subfamily significantly decreased (59.1% decrease) in 24-h kplps rats (lipopolysaccharide derived from klebsiella pneumoniae; the protein expression was measured 24h after kplps administration) compared with that in control rats, but restored to that in control rats in 96-h kplps rats. | 2008 | 18976719 |
| multicenter study to assess the in vitro activity of tigecycline by disk diffusion test against clinical isolates from argentina. | tigecycline is a new antibiotic currently used in healthcare environments where multidrug resistance is prominent. because there is a constant potential for resistance to emerge, survey studies are needed. | 2009 | 18974645 |
| molecular characterization of nosocomial ctx-m type beta-lactamase producing enterobacteriaceae from a tertiary care hospital in south india. | ctx-m group of extended spectrum beta lactamases (esbls) represents a rapidly emerging problem in many countries. the prevalence of nosocomial bla ctx-m-1 producing enterobacteriaceae strains has not been reported earlier in indian hospitals. this study describes molecular subtyping of nosocomial bla ctx-m producing strains of enterobacteriaceae . polymerase chain reaction with primers specific for bla ctx-m-1 coding genes was used to identify 95 enterobacteriaceae strains producing bla ctx-m po ... | 2008 | 18974492 |
| highly resistant microorganisms in a teaching hospital: the role of horizontal spread in a setting of endemicity. | to determine the incidence density of highly resistant organisms (hros) and the relative contribution of horizontal spread in a setting of endemicity. | 2008 | 18973456 |
| outcomes of carbapenem-resistant klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. | carbapenem-resistant klebsiella pneumoniae is an emerging healthcare-associated pathogen. | 2008 | 18973455 |
| klebsiella pneumoniae carbapenemase-producing organisms: an ounce of prevention really is worth a pound of cure. | 2008 | 18973453 | |
| a survey on species and prevalence rate of bacterial agents isolated from cockroaches in three hospitals. | the presence of cockroaches has health implications, such as nosocomial infection, as the insects move freely from areas within and around hospitals that may harbor pathogenic organisms. the goals of the present study were to determine species of bacteria isolated from cockroaches found in three tehran hospitals, and to determine distribution of potential vectors by species and sex. the study is descriptive laboratory research. a total of 305 cockroaches from three species were trapped and ident ... | 2009 | 18973441 |
| evidence for clonal dissemination of the serotype k1 klebsiella pneumoniae strain causing invasive liver abscesses in korea. | seventy-three liver abscess isolates of serotype k1 klebsiella pneumoniae from a nationwide collection in korea were genotypically characterized using pulsed-field gel electrophoresis and multilocus sequence typing. we found that serotype k1 k. pneumoniae strains that caused liver abscesses in korea were genotypically related and that most were sequence type 23. | 2008 | 18971367 |
| klebsiella oxytoca necrotizing fasciitis after orthotopic heart transplant. | we report a case of klebsiella necrotizing fasciitis after heart transplantation. the infection required debridement of discontinuous areas on three extremities as well as on the trunk. klebsiella sp necrotizing fasciitis is a rare entity and has not been described previously in concert with heart transplantation. klebsiella cases classically have skip lesions as described herein. klebsiella oxytoca is a rare cause of necrotizing fasciitis in north america and presents with multifocal infection ... | 2008 | 18971102 |