Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| synthesis and antibacterial activity of new n-linked 5-triazolylmethyl oxazolidinones. | a new series of n-linked 5-triazolylmethyl oxazolidinones with varying substitution at the piperazine nitrogen 4-position were synthesized and tested against a panel of gram-positive and gram-negative bacteria including clinical isolates. most of the compounds showed excellent antibacterial activity against susceptible and resistant gram-positive organisms. one of the compounds showed enhanced antibacterial activity against moraxella catarrhalis. | 2005 | 15911326 |
| investigation about the homogeneity of nasopharyngeal microflora at the different location of nasopharynx of children with acute otitis media. | nasopharynx is thought to be a very important site as becterial reservoir for acute otitis media (aom). in this study, we investigated on the homogeneity of nasopharyngeal microflora at the different location of nasopharynx of children with aom. | 2005 | 15911015 |
| identification of surface antigens of moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease. | moraxella catarrhalis is an important respiratory tract pathogen, causing otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (copd). adults with copd make antibody responses to m. catarrhalis following infection, but little is known about the identity of the antigens to which these antibodies are directed. in this study, 12 serum samples obtained from adults with copd who had cleared m. catarrhalis from the respiratory tract follo ... | 2005 | 15908376 |
| gemifloxacin for the treatment of respiratory tract infections: in vitro susceptibility, pharmacokinetics and pharmacodynamics, clinical efficacy, and safety. | gemifloxacin is a synthetic fluoroquinolone antimicrobial agent exhibiting potent activity against most gram-negative and gram-positive organisms, such as the important community-acquired respiratory pathogens streptococcus pneumoniae (including multidrug-resistant s. pneumoniae), haemophilus influenzae , and moraxella catarrhalis . the agent's mechanism of action involves dual targeting of two essential bacterial enzymes: dna gyrase and topoisomerase iv. gemifloxacin was approved by the food an ... | 2005 | 15899734 |
| guide to selection of fluoroquinolones in patients with lower respiratory tract infections. | newer fluoroquinolones such as levofloxacin, moxifloxacin, gatifloxacin and gemifloxacin have several attributes that make them excellent choices for the therapy of lower respiratory tract infections. in particular, they have excellent intrinsic activity against streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis and the atypical respiratory pathogens. fluoroquinolones may be used as monotherapy to treat high-risk patients with acute exacerbation of chronic bronchitis, and fo ... | 2005 | 15892589 |
| telithromycin: a ketolide antibiotic for treatment of respiratory tract infections. | telithromycin, a recently approved ketolide antibiotic derived from 14-membered macrolides, is active against erythromycin-resistant pneumococci. telithromycin has enhanced activity in vitro because it binds not only to domain v of ribosomal rna (like macrolides do) but also to domain ii. however, it is not active against streptococci and staphylococci with constitutive macrolide, lincosamide, and streptogramin b resistance. telithromycin, available in an oral formulation, is approved by the us ... | 2005 | 15889365 |
| bacteriology of chronic maxillary sinusitis associated with nasal polyposis. | aspirates from 48 chronically inflamed maxillary sinuses from patients who had nasal polyposis were processed for aerobic and anaerobic bacteria. bacterial growth was present in 46 (96%) specimens. aerobic or facultative bacteria were present in 6 (13%) specimens, anaerobic bacteria alone in 18 (39%), and mixed aerobic and anaerobic bacteria in 22 (48%). there were 110 bacterial isolates (2.4 per specimen). thirty-nine of the isolates were aerobic or facultative organisms (0.85 per specimen). th ... | 2005 | 15888469 |
| long-term effects on the nasopharyngeal flora of children following antimicrobial therapy of acute otitis media with cefdinir or amoxycillin-clavulanate. | the effect on the nasopharyngeal bacterial flora of 10 days of amoxycillin-clavulanate or cefdinir antimicrobial therapy was studied in 50 children with acute otitis media. before therapy, 17 potential pathogens (streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis) were isolated from the nasopharynx of 14 (56%) of those treated with amoxycillin-clavulanate, and 20 potential pathogens were recovered from 15 (60%) of those treated with cefdinir. following therapy, at days 12 ... | 2005 | 15888464 |
| steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline. | the steady-state serum and intrapulmonary pharmacokinetic and pharmacodynamic parameters of tigecycline were determined after intravenous administration in 30 subjects. tigecycline was administered as a 100mg loading dose followed by six 50mg doses given every 12h and was measured using hplc/mass spectrometry. ratios of tigecycline maximum serum concentration and area under the serum concentration-time curve to 90%-minimum inhibitory concentrations (c(max)/mic(90); auc/mic(90)), and percentage t ... | 2005 | 15885987 |
| microbiology of middle ear effusions from 292 patients undergoing tympanostomy tube placement for middle ear disease. | otitis media is one of the most commonly diagnosed childhood illnesses. ideally, culture directed therapy for otitis media would be available, however, the common approach is to treat infections with antibiotics that cover the most common pathogens. the objective of this study is to describe the pathogens cultured from the middle ear effusions (mee) of patients that underwent tympanostomy tube placement for middle ear disease, compare these results with previous studies, and assess for trends su ... | 2005 | 15885332 |
| treatment of acute exacerbation of severe-to-very severe copd with azithromycin in patients vaccinated against streptococcus pneumoniae. | sixty-five consecutive eligible adult patients, who were treated as outpatients for stable severe-to-very severe copd, were enrolled in the study. all of them received 23-valent pneumococcal capsular polysaccharide vaccine intramuscularly. patients were seen monthly, as well as whenever they had symptoms suggestive of an exacerbation, at our outpatient clinic. eighteen out of 65 patients suffered from acute exacerbation (aecopd). three of these patients presented two episodes of aecopd. patients ... | 2005 | 15878482 |
| pharmacodynamics of an 800-mg dose of telithromycin in patients with community-acquired pneumonia caused by extracellular pathogens. | the pharmacodynamics of telithromycin, a new ketolide antibacterial, was examined in 115 patients with community-acquired pneumonia (cap). patients received telithromycin 800 mg qd for 7-10 days. pharmacokinetic parameters were determined, and exposure was linked to microbiological outcome using logistic regression analysis. a breakpoint for increased probability of microbiological eradication was developed and was found to be the ratio of area under the concentration-time curve (auc) to minimum ... | 2005 | 15878442 |
| new antimicrobial agents approved by the u.s. food and drug administration in 2004 and new indications for previously approved agents. | 2005 | 15855554 | |
| antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin. | ceftobiprole (previously known as bal9141), an anti-methicillin-resistant staphylococcus aureus cephalosporin, was very highly active against a panel of 299 drug-susceptible and -resistant pneumococci, with mic(50) and mic(90) values (microg/ml) of 0.016 and 0.016 (penicillin susceptible), 0.06 and 0.5 (penicillin intermediate), and 0.5 and 1.0 (penicillin resistant). ceftobiprole, imipenem, and ertapenem had lower mics against all pneumococcal strains than amoxicillin, cefepime, ceftriaxone, ce ... | 2005 | 15855516 |
| mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of trna footprinting at the decoding site of 16s rrna. | the novel ribosome inhibitors (nris) are a broad-spectrum naphthyridine class that selectively inhibits bacterial protein synthesis (p. j. dandliker et al., antimicrob. agents chemother. 47:3831-3839, 2003). footprinting experiments, using a range of nris and chemical modification agents on escherichia coli ribosomes, revealed no evidence for direct protection of rrna. in the presence of trna, however, we found that nris enhanced the known ribosomal footprinting pattern of trna in a dose-depende ... | 2005 | 15855511 |
| telithromycin: the first ketolide for the treatment of respiratory infections. | the pharmacology, mechanisms of resistance, in vitro activity, clinical efficacy, pharmacokinetics, indications, adverse effects, dosage and administration, and place in therapy of telithromycin in the treatment of respiratory infections are reviewed. | 2005 | 15851496 |
| [in vitro susceptibilites to levofloxacin and various antibacterial agents of 11,475 clinical isolates obtained from 52 centers in 2002]. | the susceptibilities of bacteria to fluoroquinolones (fqs), especially levofloxacin, and other antimicrobial agents were investigated using 11,475 clinical isolates collected in japan during 2002. methicillin susceptible staphylococci, streptococcus pyogenes, streptococcus pneumoniae, moraxella catarrhalis, the family of enterobactericeae, haemophilus influenzae and acinetobacter spp. exhibited stable and high susceptibilities to fqs. the rate of fqs-resistant mrsa was 80 approximately 90%, bein ... | 2005 | 15849869 |
| a novel plasmid (pemcjh03) isolated from moraxella catarrhalis possibly useful as a cloning and expression vector within this species. | a preliminary screening study of six moraxella catarrhalis isolates from primary school children in the netherlands identified a small 3.5 kb plasmid (pemcjh03), containing four open reading frames, which encoded three mobilizing and one replicase protein. insertion of a kanamycin containing transposon (yielding pemcjh04) allowed selection and isolation of the plasmid in escherichia coli. natural transformation of pemcjh04 into m. catarrhalis was successful for 25% (3/12) of non-isogenic isolate ... | 2004 | 15848230 |
| the use of macrolides in treatment of upper respiratory tract infections. | antimicrobial resistance is a growing problem among upper respiratory tract pathogens. resistance to beta-lactam drugs among streptococcus pneumoniae, haemophilus influenzae, and streptococcus pyogenes is increasing. as safe and well-tolerated antibiotics, macrolides play a key role in the treatment of community-acquired upper respiratory tract infections (rtis). their broad spectrum of activity against gram-positive cocci, such as s. pneumoniae and s. pyogenes, atypical pathogens, h. influenzae ... | 2005 | 15847719 |
| synthesis and characterization of lipooligosaccharide-based conjugate vaccines for serotype b moraxella catarrhalis. | moraxella catarrhalis is an important cause of otitis media in children and respiratory tract infections in the elderly. lipooligosaccharide (los) is a major surface antigen of the bacterium that elicits bactericidal antibodies. serological studies show that three major los types (a, b, and c) have been identified among clinical isolates. our previous studies demonstrated that the type a los-based conjugates were immunogenic in animals. in this study, los from type b strain 26397 was detoxified ... | 2005 | 15845482 |
| outer membrane protein p6 of nontypeable haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines. | interactions of nontypeable haemophilus influenzae (nthi) with human macrophages contribute to the pathogenesis of nthi-induced infection in humans. however, the immunologic mechanisms that initiate and perpetuate nthi-mediated macrophage responses have not been well explored. outer membrane protein (omp) p6 is a conserved lipoprotein expressed by nthi in vivo that possesses a pam(3)cys terminal motif, characteristic of immunoactive bacterial lipoproteins associated with toll-like receptor signa ... | 2005 | 15845475 |
| characterization of a cluster of three glycosyltransferase enzymes essential for moraxella catarrhalis lipooligosaccharide assembly. | moraxella catarrhalis isolates express lipooligosaccharide (los) molecules on their surface, which share epitopes similar to that of the neisseria and haemophilus species. these common los epitopes have been implicated in various steps of pathogenesis for the different organisms. in this study, a cluster of three los glycosyltransferase genes (lgt) were identified in m. catarrhalis 7169, a strain that produces a serotype b los. mutants in these glycosyltransferase genes were constructed, and the ... | 2005 | 15838019 |
| pathogenesis of afa/dr diffusely adhering escherichia coli. | over the last few years, dramatic increases in our knowledge about diffusely adhering escherichia coli (daec) pathogenesis have taken place. the typical class of daec includes e. coli strains harboring afae-i, afae-ii, afae-iii, afae-v, dr, dr-ii, f1845, and nfa-i adhesins (afa/dr daec); these strains (i) have an identical genetic organization and (ii) allow binding to human decay-accelerating factor (daf) (afa/dr(daf) subclass) or carcinoembryonic antigen (cea) (afa/dr(cea) subclass). the atypi ... | 2005 | 15831825 |
| usefulness of the japanese respiratory society guidelines for community pneumonia: a retrospective analysis of community-acquired pneumonia between 2000 and 2002 in a general hospital. | the aim of this study was to investigate the causative organisms of community-acquired pneumonia (cap) diagnosed between 2000 and 2002 and to evaluate the japanese respiratory society (jrs) guidelines. | 2005 | 15823187 |
| microbiology of sinusitis and the predictive value of throat culture for the aetiology of sinusitis. | a prospective study of throat cultures and maxillary sinus aspirates from children with chronic sinusitis (n = 21), acute sinusitis (n = 28) or a clinical diagnosis of chronic adenoiditis (n = 41) was performed. seventy-two bacterial pathogens were isolated from sinus aspirates from 52% of the study population. haemophilus influenzae was most common pathogen, followed by moraxella catarrhalis, streptococcus pneumoniae, staphylococcus aureus, and group a streptococci. quantitative throat cultures ... | 2005 | 15819870 |
| moraxella catarrhalis-induced septic arthritis of a prosthetic knee joint in a patient with rheumatoid arthritis treated with anakinra: comment on the article by schiff et al. | 2005 | 15818660 | |
| identification of a conserved moraxella catarrhalis haemoglobin-utilization protein, mhua. | moraxella catarrhalis is a leading cause of acute otitis media in children and is a cause of respiratory disease in adults with underlying lung disease. this organism is a strict human pathogen that has an absolute requirement for iron in order to grow and cause disease. previous studies identified transferrin and lactoferrin receptors used by m. catarrhalis to obtain iron from the human host, yet other iron-acquisition systems remain undefined. in this study, it is demonstrated that this strict ... | 2005 | 15817782 |
| antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (penicillin) study. | the prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (aurtis) is not clear. we conducted a prospective community-based multicenter study in 45 centers across nagasaki, japan, between december 2001 and april 2002. we examined the nasopharyngeal or throat isolates in 930 adult outpatients with aurtis. potential bacterial pathogens, including streptococcus pyogenes (from 6.8% patients), s. pneumoniae (5.3%), s. milleri group (2.0%) ... | 2005 | 15808319 |
| cefdinir: an oral alternative to parenteral cephems. | cost savings are possible if oral cephems of equivalent efficacy can be substituted for parenteral cephems. an in vitro study was performed to compare the activity of cefdinir, cefoxitin, cefazolin, ceftriaxone, ceftazidime, and cefepime against 243 clinical isolates of human pathogens. activities were determined by national committee for clinical laboratory standards microbroth dilution methodology using an inoculum of approximately 5 x 10(5) cfu/ml. cefdinir was the single or equally most pote ... | 2005 | 15808317 |
| moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. | moraxella catarrhalis is frequently present in the sputum of adults with chronic obstructive pulmonary disease (copd). little is known about the role of m. catarrhalis in this common disease. | 2005 | 15805178 |
| etiology of community-acquired pneumonia. | community-acquired pneumonia (cap) is a serious lower respiratory tract infection associated with significant morbidity and mortality that is characterized by disputes over diagnostic evaluations and therapeutic decisions. with the widespread use of broad-spectrum antimicrobial agents and the increasing number of immunocompromised hosts, the etiology and the drug resistance patterns of pathogens responsible for cap have changed. streptococcus pneumoniae, haemophilus influenzae, and moraxella cat ... | 2005 | 15802165 |
| weekly point prevalence of streptococcus pneumoniae, hemophilus influenzae and moraxella catarrhalis in the upper airways of normal young children: effect of respiratory illness and season. | the aim was to determine the effect of respiratory illness and season on carriage rates in the upper airways of streptococcus pneumoniae, hemophilus influenzae and moraxella catarrhalis in normal children. sixteen healthy children, 1-10 years old, amenable to weekly sampling were followed longitudinally for at least three seasons of the year. respiratory symptoms were recorded daily; weekly nasal aspirate/wash samples were cultured on selective agars. urea concentration in samples was used to de ... | 2005 | 15799766 |
| mutant prevention concentrations of abt-492, levofloxacin, moxifloxacin, and gatifloxacin against three common respiratory pathogens. | the purpose of this study was to compare the mutant prevention concentration (mpc) of abt-492 to those of levofloxacin, moxifloxacin, and gatifloxacin against streptococcus pneumoniae, haemophilus influenzae, and moraxella catarrhalis. the fluoroquinolones had comparable mutation selection windows, which is the ratio of mpc/mic, for all isolates. | 2005 | 15793158 |
| comparative antimicrobial characterization of lbm415 (nvp pdf-713), a new peptide deformylase inhibitor of clinical importance. | lbm415 (nvp pdf-713) is the first member of the peptide deformylase (pdf) inhibitor class being developed for clinical trials as a parenteral and oral agent for treatment of community-acquired respiratory tract disease and serious infections caused by antimicrobial-resistant gram-positive cocci. in this study susceptibility testing results from 1,306 recent clinical isolates selected to over-represent resistance trends among the species were summarized. all staphylococci (153 strains; mic at whi ... | 2005 | 15793128 |
| acquisition of resistance to carbapenems in multidrug-resistant clinical strains of acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins. | the outer membrane proteins responsible for the influx of carbapenem beta-lactam antibiotics in the nonfermentative gram-negative pathogen acinetobacter baumannii are still poorly characterized. resistance to both imipenem and meropenem in multidrug-resistant clinical strains of a. baumannii is associated with the loss of a heat-modifiable 29-kda outer membrane protein, designated caro. the chromosomal locus containing the caro gene was cloned and characterized from different clinical isolates. ... | 2005 | 15793123 |
| the uspa2 protein of moraxella catarrhalis is directly involved in the expression of serum resistance. | many strains of moraxella catarrhalis are resistant to the bactericidal activity of normal human serum. previous studies have shown that mutations involving the insertion of an antibiotic resistance cartridge into the m. catarrhalis uspa2 gene resulted in the conversion of a serum-resistant strain to a serum-sensitive phenotype. in the present study, the deletion of the entire uspa2 gene from the serum-resistant m. catarrhalis strain o35e resulted in a serum-sensitive phenotype and did not affec ... | 2005 | 15784586 |
| haemophilus ducreyi outer membrane determinants, including dsra, define two clonal populations. | the haemophilus ducreyi outer membrane component dsra (for ducreyi serum resistance a) is necessary for complete resistance to normal human serum (nhs). when dsra expression in 19 temporally and geographically diverse clinical isolates of h. ducreyi was examined by western blotting, 5 of the strains expressed a different immunotype of the dsra protein (dsra(ii)) than the well-characterized prototypical strain 35000hp (dsra(i)). the predicted dsra proteins expressed by the dsra(ii) strains were 1 ... | 2005 | 15784585 |
| nasopharyngeal colonization by moraxella catarrhalis and study of antimicrobial susceptibility in healthy children from cuban day-care centers. | the prevalence of nasopharyngeal carriage of moraxella catarrhalis was determined for the first time in cuba. one-hundred fifty healthy children attending three day-care centers in the municipality of marianao, havana city were studied. the percentage of recovering bacteria in nasal and pharyngeal swabs was compared. antimicrobial susceptibilities to ampicillin, trimethoprim-sulfamethoxazole, tetracycline, cefotaxime, ceftriaxone, chloramphenicol, erythromycin, azithromycin, amoxicillin/clavulan ... | 2005 | 15778001 |
| transcriptional slippage in bacteria: distribution in sequenced genomes and utilization in is element gene expression. | transcription slippage occurs on certain patterns of repeat mononucleotides, resulting in synthesis of a heterogeneous population of mrnas. individual mrna molecules within this population differ in the number of nucleotides they contain that are not specified by the template. when transcriptional slippage occurs in a coding sequence, translation of the resulting mrnas yields more than one protein product. except where the products of the resulting mrnas have distinct functions, transcription sl ... | 2005 | 15774026 |
| [susceptibility of branhamella catarrhalis to antibiotics]. | a total of 98 isolates of branhamella catarrhalis were examined for their susceptibility to antibiotics using serial dilution method. nitrocefin test was employed for detection of beta-lactamase activity. it was found that most of the isolates (71%) were resistant to ampicillin. resistance to this antibiotic was accompanied by ability to beta-lactamase production. on the other hand, all isolates were susceptible to amoxicillin + clavulanic acid combination. almost all isolates were susceptible t ... | 2004 | 15773499 |
| in vitro investigation of the indirect pathogenicity of beta-lactamase-producing microorganisms in the nasopharyngeal microflora. | nasopharyngeal microflora contains some beta-lactamase-producing microorganisms. in this study, we investigated in vitro on the indirect pathogenicities of haemophilus parainfluenzae (h. parainfluenzae) and moraxella catarrhalis (m. catarrhalis) against the antipneumococcul activities of some beta-lactams. | 2005 | 15763284 |
| mimivirus in pneumonia patients. | mimivirus, the largest virus known to date, is an amebal pathogen-like legionella sp. when mimivirus was used as an antigen in a microimmunofluorescense assay, seroconversion was found in patients with both community- and hospital-acquired pneumonia. mimivirus dna was found in respiratory samples of a patient with hospital-acquired pneumonia. | 2005 | 15757563 |
| moxifloxacin in respiratory tract infections. | moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against respiratory pathogens, including gram-positive (streptococcus pneumoniae), gram-negative (haemophilus influenzae, moraxella catarrhalis), and atypical strains (chlamydia pneumoniae, mycoplasma pneumoniae), as well as multi-drug resistant s. pneumoniae, including strains resistant to penicillin, macrolides, tetracyclines, trimethoprim/sulfamethoxazole and some fluoroquinolones. moxifloxacin is highly c ... | 2005 | 15757424 |
| bacterial otitis media: a vaccine preventable disease? | otitis media (om) is the most common childhood illness for which medical advice is sought. whilst the disease rarely results in death, there is a significant level of morbidity and economic burden on the community. although the causes of om are multifactoral, bacterial and viral infections are the single most important cause. bacteria responsible for infections of the middle ear are predominantly, nontypeable haemophilus influenzae, streptococcus pneumoniae and moraxella catarrhalis. antibiotics ... | 2005 | 15755616 |
| antibiotic activity of telithromycin and comparators against bacterial pathogens isolated from 3,043 patients with acute exacerbation of chronic bronchitis. | antimicrobial therapy is considered an important component in the medical management of most patients with acute exacerbation of chronic bronchitis (aecb). the three predominant bacterial species isolated are nontypeable haemophilus influenzae, moraxella catarrhalis, and streptococcus pneumoniae. staphylococcus aureus is also frequently isolated while atypical bacteria are thought to cause up to 10% of exacerbations. antibacterial resistance is increasing worldwide and little surveillance data e ... | 2005 | 15755326 |
| mixed bacterial meningitis due to streptococcus pneumoniae and neisseria meningitidis in an 18-month-old child. | we report an unusual case of culture-proven pneumococcal and meningococcal mixed meningitis in an 18-month-old girl. the patient responded well to antimicrobial therapy and recovered completely without sequelae. no underlying condition could be demonstrated except a rhinitis of unknown etiology 2 days before the onset of the symptoms suggesting meningitis. | 2005 | 15750140 |
| bacteriological efficacy of 5-day therapy with telithromycin in acute maxillary sinusitis. | increasing resistance among the key pathogens responsible for community-acquired respiratory tract infections, namely streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis, has the potential to limit the effectiveness of the antibacterial agents available to treat these infections. moreover, there are regional differences in the susceptibility patterns observed and, as treatment is usually empirical, choosing an effective treatment can be challenging. telithromycin, the firs ... | 2005 | 15737519 |
| moraxella catarrhalis strains with reduced expression of the uspa outer membrane proteins belong to a distinct subpopulation. | the outer membrane proteins uspa1 and uspa2 are candidate antigens for a moraxella catarrhalis vaccine. we previously reported that 103 of 108 isolates (95%) from young children expressed uspa1 detected by reactivity with the monoclonal antibody mab24b5. the aim of the present study was to investigate mechanisms controlling uspa1 expression by analysis of five mab24b5 non-reactive isolates. four of these strains were characterized by (i) decreased or absent transcription of uspa1 and uspa2 and ( ... | 2005 | 15734074 |
| major bacteria of community-acquired respiratory tract infections in turkey. | to determine the bacterial etiology of lower respiratory tract infections (lrtis) in turkey, quantitative cultures of sputum were carried out. the major pathogens for ltris were found to be haemophilus influenzae, followed by streptococcus pneumoniae and moraxella catarrhalis. only 6.1% of the h. inlfuenzae and all strains of m. catarrhalis were beta-lactamase producers. an e-test showed that 31.2% of the s. pneumoniae strains had an intermediate resistance to penicillin, and the remaining strai ... | 2005 | 15728995 |
| [moraxella catarrhalis in chronic and relapsing respiratory tract infections in children]. | examination of 700 children with chronic and relapsing respiratory tract infections showed that during the period from 1996 to 2003 moraxella catarrhalis strains were isolated from the sputum of 5.5-9.7% of the patients. the frequency of the emergence was the third after haemophilus influenzae and streptococcus pneumoniae. in healthy children m. catarrhalis was isolated in 2.7% of the cases. the most frequent detection of m. catarrhalis was stated in children under 1 year (4.5%). the antibiotic ... | 2004 | 15727145 |
| once-daily azithromycin for 3 days compared with clarithromycin for 10 days for acute exacerbation of chronic bronchitis: a multicenter, double-blind, randomized study. | to compare the efficacy and safety of oral azithromycin 500 mg once daily for 3 days with those of oral clarithromycin 500 mg twice daily for 10 days. | 2005 | 15725048 |
| carcinoembryonic antigen-related cell adhesion molecule (ceacam)-binding recombinant polypeptide confers protection against infection by respiratory and urogenital pathogens. | the human-specific pathogens neisseria meningitidis, n. gonorrhoea, haemophilus influenzae and moraxella catarrhalis share the property of targeting the carcinoembryonic antigen (cea)-related cell adhesion molecules (ceacams) expressed on human epithelia. ceacams are signalling receptors implicated in cell adhesion and regulation of several physiological functions. their targeting by pathogens can lead to tissue invasion. although the ceacam-binding ligands of the bacteria are structurally diver ... | 2005 | 15720557 |
| induction of cd69 expression and th1 cytokines release from human peripheral blood lymphocytes after in vitro stimulation with alloiococcus otitidis and three middle ear pathogens. | alloiococcus otitidis is a recently discovered pathogen of otitis media. however, only a limited number of studies are available about the pathogenic and immunological role of a. otitidis. the aim of this study was to investigate the activation and the cytokine production of human peripheral blood lymphocytes at the early immune response after stimulation with a. otitidis. after stimulation of whole human peripheral blood lymphocytes for 18 h with whole killed a. otitidis or the three major midd ... | 2005 | 15708312 |
| high prevalence of antibiotic resistance in isolates from the middle meatus of children and adults with acute rhinosinusitis. | the pathogens in acute rhinosinusitis are similar worldwide. an increase in antibiotic resistance has been shown in a large number of studies in recent years. the prevalence of resistance varies greatly in different countries. this study was performed to determine the endemic prevalence of antibiotic resistance in pathogens of acute rhinosinusitis in taiwan. | 2004 | 15706987 |
| clustering the annotation space of proteins. | current protein clustering methods rely on either sequence or functional similarities between proteins, thereby limiting inferences to one of these areas. | 2005 | 15703069 |
| [the pathogen spectrum of acute bacterial rhinitis/sinusitis and antibiotic resistance]. | bacterial rhinosinusitis is one of the most frequent indications for an antibiotic therapy. the objective of this study was the analysis of the current pathogen spectrum and its antimicrobial susceptibility. | 2005 | 15702353 |
| a randomized, multicenter, double blind, double dummy trial of single dose azithromycin versus high dose amoxicillin for treatment of uncomplicated acute otitis media. | high dose amoxicillin is recommended for the initial treatment of children with acute otitis media (aom), particularly patients at risk for having drug-resistant streptococcus pneumoniae. single dose azithromycin (30 mg/kg) is considered an alternative agent for the treatment of aom. | 2005 | 15702045 |
| [molecular characterization of bro beta-lactamases of moraxella catarrhalis strains isolated from carrier children]. | nasopharyngeal carriage of moraxella catarrhalis is a risk factor for upper respiratory tract infections and otitis media. in this study, we aimed to characterize bro beta-lactamases of m. catarrhalis strains isolated from 64 children without any symptoms of respiratory disease. gram negative diplococci grown on selective media and which are catalase, oxidase, dnase, nitrate reduction positive, glucose, maltose, sucrose and lactose fermentation negative, were diagnosed as m. catarrhalis. antibio ... | 2004 | 15700658 |
| use of the microseq 500 16s rrna gene-based sequencing for identification of bacterial isolates that commercial automated systems failed to identify correctly. | reliable automated identification and susceptibility testing of clinically relevant bacteria is an essential routine for microbiology laboratories, thus improving patient care. examples of automated identification systems include the phoenix (becton dickinson) and the vitek 2 (biomerieux). however, more and more frequently, microbiologists must isolate "difficult" strains that automated systems often fail to identify. an alternative approach could be the genetic identification of isolates; this ... | 2005 | 15695654 |
| the pneumoplex assays, a multiplex pcr-enzyme hybridization assay that allows simultaneous detection of five organisms, mycoplasma pneumoniae, chlamydia (chlamydophila) pneumoniae, legionella pneumophila, legionella micdadei, and bordetella pertussis, and its real-time counterpart. | respiratory disease caused by atypical bacteria remains an important cause of morbidity and mortality for adults and children, despite the widespread use of effective antimicrobials agents. culture remains the "gold standard" for the detection of these agents. however, culture is labor-intensive, takes several days to weeks for growth, and can be very insensitive for the detection of some of these organisms. newer singleplex pcr diagnostic tests are sensitive and specific, but multiple assays wo ... | 2005 | 15695646 |
| resistance trends in moraxella catarrhalis (protekt years 1-3 [1999-2002]). | 2004 | 15690686 | |
| the cd19 molecule is crucial for mid-dependent activation of tonsillar b cells from children. | the moraxella immunoglobulin (ig) d-binding protein (mid) induces a strong proliferative response in human peripheral blood igd+ b cells from adults isolated by positive selection using anti-cd19-conjugated microbeads. here, we show that tonsillar b cells from children isolated with positive selection are unable to respond to mid stimulation. the proliferative response was very low or absent at various concentrations of mid tested and at different time points analysed, whereas the mid response o ... | 2005 | 15683453 |
| pppa, a surface-exposed protein of streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model. | the multivalent pneumococcal conjugate vaccine is effective against both systemic disease and otitis media caused by serotypes contained in the vaccine. however, serotypes not covered by the present conjugate vaccine may still cause pneumococcal disease. to address these serotypes, and the remaining otitis media due to streptococcus pneumoniae, efforts have been devoted to identifying protective protein antigens. immunity to conserved surface proteins important for adhesion, nutrient acquisition ... | 2005 | 15664941 |
| antimicrobial resistance in streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis and group a beta-haemolytic streptococci in 2002-2003. results of the multinational grasp surveillance program. | a multinational surveillance study, grasp, was conducted between november 2002 and april 2003 with the aim of assessing rates of antimicrobial resistance among 2656 isolates of streptococcus pneumoniae, 2486 isolates of group a beta-haemolytic streptococci, 1358 isolates of haemophilus influenzae and 1047 of moraxella catarrhalis from 20 countries in europe, eastern asia and southern africa. conspicuous differences between various countries were noted in the s. pneumoniae resistance rates observ ... | 2005 | 15664485 |
| pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models. | the bacterial time-kill curves of cefpodoxime and cefixime against four bacterial strains (haemophilus influenzae, moraxella catarrhalis, streptococcus pneumoniae/penicillin sensitive and s. pneumoniae/penicillin intermediate) were compared in in vitro infection models in which various human pharmacokinetic profiles of unbound antibiotic were simulated. this approach offers more detailed information than the minimum inhibitory concentration (mic) does about the time course of antibacterial effic ... | 2005 | 15664481 |
| antimicrobial susceptibility of community-acquired respiratory tract pathogens in the uk during 2002/3 determined locally and centrally by bsac methods. | to determine the antimicrobial susceptibility of haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae causing community-acquired lower respiratory tract infection in the uk during 2002/2003 and to compare susceptibilities determined locally by disc diffusion with agar dilution mics determined at a central laboratory. | 2005 | 15649996 |
| nasopharyngeal aerobic bacterial flora and staphylococcus aureus nasal carriage in deaf children. | to determine the nasopharyngeal aerobic bacterial flora and staphylococcus aureus nasal carriage in deaf children and the role of flora in deafness. | 2005 | 15627450 |
| a mutation in the sap operon attenuates survival of nontypeable haemophilus influenzae in a chinchilla model of otitis media. | bacteria have evolved strategies to resist killing by antimicrobial peptides (aps), important effectors of innate immunity. the sap (sensitivity to antimicrobial peptides) operon confers resistance to ap-mediated killing of salmonella. we have recently shown that sapa gene expression is upregulated in the middle ear in a chinchilla model of nontypeable haemophilus influenzae (nthi)-induced otitis media. based on these findings, we constructed an nthi strain containing a lux reporter plasmid driv ... | 2005 | 15618200 |
| serine-to-asparagine substitution in the gyra gene leads to quinolone resistance in moxifloxacin-exposed chlamydia pneumoniae. | quinolone resistance of chlamydia pneumoniae has not been described previously. serial subcultures of c. pneumoniae under increasing moxifloxacin concentrations (0.0125 to 6.4 mg/liter) resulted in a 256-fold mic increase compared to moxifloxacin-naive strains. gyra gene sequencing revealed a novel point mutation with a ser-->asn substitution. subcultures under rifalazil and macrolides did not alter the respective mics. | 2005 | 15616321 |
| in vitro activities of novel 2-fluoro-naphthyridine-containing ketolides. | in vitro activities of erythromycin a, telithromycin, and two investigational ketolides, jnj-17155437 and jnj-17155528, were evaluated against clinical bacterial strains, including selected common respiratory tract pathogens. against 46 macrolide-susceptible and -resistant streptococcus pneumoniae strains, the mic(90) (mic at which 90% of the isolates tested were inhibited) of the investigational ketolides was 0.25 microg/ml, twofold lower than that of telithromycin and at least 64-fold lower th ... | 2005 | 15616310 |
| efficacy and safety of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 milligrams twice daily for 5 days versus amoxicillin-clavulanate at 875/125 milligrams twice daily for 7 days in the treatment of acute exacerbations of chronic bronchitis. | this randomized, controlled trial was designed to show that a short, 5-day course of pharmacokinetically enhanced amoxicillin-clavulanate at 2,000/125 mg (augmentin xr) is as effective clinically as a longer, 7-day course of conventional amoxicillin-clavulanate at 875/125 mg (both given twice daily) in the treatment of acute exacerbations of chronic bronchitis (aecb). amoxicillin-clavulanate at 2,000/125 mg was designed to extend the therapeutic levels of amoxicillin in serum over the 12-h dosin ... | 2005 | 15616290 |
| short-course therapy for acute sinusitis: how long is enough? | this review examines the issues surrounding short-course antibiotic therapy of acute sinusitis. acute bacterial sinusitis is a common community-acquired infection defined as inflammation of one or more paranasal sinuses, most often the maxillary sinus. it is estimated that 0.5-5% of colds are complicated by acute sinusitis. up to 1 in 20 upper respiratory tract infections is complicated by bacterial sinusitis, most often caused by streptococcus pneumoniae, haemophilus influenzae, moraxella catar ... | 2004 | 15606217 |
| protekt 1999-2000: a multicentre study of the antimicrobial susceptibility of respiratory tract pathogens in japan. | a six-centre study in japan during the winter of 1999-2000 assessed the in vitro activity of >20 antimicrobial agents against the common respiratory pathogens streptococcus pneumoniae, streptococcus pyogenes, haemophilus influenzae, and moraxella catarrhalis. the minimum inhibitory concentrations (mic) of each antimicrobial was determined against these isolates using national committee for clinical laboratory standards (nccls) methodology. | 2005 | 15603993 |
| antimicrobial susceptibility of bacterial pathogens in the oropharynx of healthy school children in turkey. | information on oropharyngeal carriage rates of streptococcus pneumoniae, haemophilus influenzae, streptococcus pyogenes and moraxella catarrhalis and their resistance pattern in healthy school children in turkey is lacking. the present study was undertaken to determine the carriage rates and antimicrobial resistance of these bacterial pathogens in such children aged 6-14 yr in manisa, turkey. | 2004 | 15591635 |
| antimicrobial resistance in the nasopharyngeal flora of children with acute otitis media and otitis media recurring after amoxicillin therapy. | the objective of this study was to investigate the antimicrobial susceptibility of the organisms isolated from the nasopharynx of children who presented with acute otitis media (aom) or otitis media that recurred after amoxicillin therapy. nasopharyngeal cultures obtained from 72 patients, 40 with aom and 32 with recurrent otitis media (rom), were analysed. thirty-six potentially pathogenic organisms were recovered in 34 (85 %) of the children from the aom group, and 42 were isolated from 29 (91 ... | 2005 | 15591260 |
| in vitro activities of tigecycline against clinical isolates from shanghai, china. | to evaluate the in vitro activity of tigecycline, the minimum inhibitory concentrations (mics) of tigecycline against 1,201 strains of recent clinical isolates from 10 hospitals in shanghai, china were determined and compared with selected comparators. results showed that tigecycline had broad-spectrum antimicrobial activity. it was highly active against gram-positive cocci, including methicillin-resistant staphylococcus spp., penicillin-intermediate streptococcus pneumoniae, enterococcus faecal ... | 2004 | 15582300 |
| caregivers' practices, knowledge and beliefs of antibiotics in paediatric upper respiratory tract infections in trinidad and tobago: a cross-sectional study. | antibiotic overuse and misuse for upper respiratory tract infections in children is widespread and fuelled by public attitudes and expectations. this study assessed knowledge, beliefs, and practices regarding antibiotic use for these paediatric infections among children's caregivers' in trinidad and tobago in the english speaking caribbean. | 2004 | 15574193 |
| pharmacokinetics in animals and humans of a first-in-class peptide deformylase inhibitor. | bb-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial class to progress to clinical trials. single- and/or multiple-dose studies with doses ranging from 10 to 50 mg of bb-83698/kg of body weight were done with mice, rats, and dogs. intravenous pharmacokinetics were characterized by low to moderate clearances and moderate volumes of distribution for all species. in dogs, but not in rodents, central nervous system (cns) effects were d ... | 2004 | 15561864 |
| population pharmacokinetics and pharmacodynamics of garenoxacin in patients with community-acquired respiratory tract infections. | garenoxacin (t-3811me, bms-284756) is a novel, broad-spectrum des-f(6) quinolone currently under study for the treatment of community-acquired respiratory tract infections. this analysis assessed garenoxacin population pharmacokinetics and exposure-response relationships for safety (adverse effects [ae]) and antimicrobial activity (clinical cure and bacteriologic eradication of streptococcus pneumoniae and the grouping of haemophilus influenzae, haemophilus parainfluenzae, and moraxella catarrha ... | 2004 | 15561855 |
| moraxella catarrhalis--infected alveolar epithelium induced monocyte recruitment and oxidative burst. | the recruitment of monocytes appears to be a crucial factor for inflammatory lung disease. alveolar epithelial cells contribute to monocyte influx into the lung, but their impact on monocyte inflammatory capacity is not entirely clear. we thus analyzed the modulation of monocyte oxidative burst by a549 and isolated human alveolar epithelial cells. epithelial infection with moraxella catarrhalis induced monocyte adhesion, transepithelial migration, and superoxide generation, whereas stimulation w ... | 2005 | 15557018 |
| [specific features of humoral immunity in cryptogenic fibrosing alveolitis patients]. | cryptogenic fibrosing alveolitis (cfa) is a severe autoimmune disease of unclear etiology and prognostically unfavorable. the complexity of the diagnostics of this disease makes it necessary to search for new methods; for this reason immunity in cfa patients must be studied. the study of humoral organ-specific, organ-unspecific and antibacterial immunity of cfa patients revealed that the latter differed from the members of the groups used for comparison by a higher frequency of positive reaction ... | 2004 | 15554319 |
| the potential effect of widespread use of pneumococcal conjugate vaccines on the practice of pediatric otolaryngology: the case of acute otitis media. | this review provides the otolaryngologist with the evolving understanding of various aspects of pneumococcal conjugate vaccines (pcvs) that are related to their effect on the respiratory tract | 2004 | 15548905 |
| risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit. | to evaluate the risk of bacterial infection and use of antibiotics in otherwise healthy children infected with respiratory syncytial virus (rsv) admitted to the intensive care unit (icu). | 2004 | 15545852 |
| acute exacerbation of chronic bronchitis: a primary care consensus guideline. | to develop consensus on appropriate treatment for acute exacerbation of chronic bronchitis (aecb). characteristics and etiology: patients with chronic bronchitis have an irreversible reduction in maximal airflow velocity and a productive cough on most days of the month for 3 months over 2 consecutive years. an aecb is characterized by a period of unstable lung function with worsening airflow and other symptoms. most (80%) cases of aecb are due to infection, with half due to aerobic bacteria. the ... | 2004 | 15521160 |
| activities of two novel macrolides, gw 773546 and gw 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against haemophilus influenzae. | the mic at which 50% of strains are inhibited (mic(50)) and the mic(90) of gw 773546, a novel macrolide, were 1.0 and 2.0 microg/ml, respectively, for 223 beta-lactamase-positive, beta-lactamase-negative, and beta-lactamase-negative ampicillin-resistant haemophilus influenzae strains. the mic(50)s and mic(90)s of gw 708408, a second novel macrolide, and telithromycin, an established ketolide, were 2.0 and 4.0 microg/ml, respectively, while the mic(50) and mic(90) of azithromycin were 1.0 and 2.0 ... | 2004 | 15504829 |
| moraxella catarrhalis coaggregates with streptococcus pyogenes and modulates interactions of s. pyogenes with human epithelial cells. | the pathogens streptococcus pyogenes and moraxella catarrhalis colonize overlapping regions of the human nasopharynx. we have found that m. catarrhalis can dramatically increase s. pyogenes adherence to human epithelial cells and that species-specific coaggregation of these bacteria correlates with this enhanced adherence. | 2004 | 15501804 |
| identification of a hemin utilization protein of moraxella catarrhalis (huma). | moraxella catarrhalis is a major cause of acute otitis media in young children and has also been implicated as an important cause of exacerbations in adults with underlying pulmonary disease. due to the considerable level of antibiotic resistance and the high degree of carriage rates in young children, it is likely that the incidence of m. catarrhalis infections will continue to rise. m. catarrhalis is a strict human respiratory pathogen, and this bacterium uses both transferrin and lactoferrin ... | 2004 | 15501773 |
| expression of type iv pili by moraxella catarrhalis is essential for natural competence and is affected by iron limitation. | type iv pili, filamentous surface appendages primarily composed of a single protein subunit termed pilin, play a crucial role in the initiation of disease by a wide range of pathogenic bacteria. although previous electron microscopic studies suggested that pili might be present on the surface of moraxella catarrhalis isolates, detailed molecular and phenotypic analyses of these structures have not been reported to date. we identified and cloned the m. catarrhalis genes encoding pila, the major p ... | 2004 | 15501752 |
| comparative in vitro activity of a pharmacokinetically enhanced oral formulation of amoxicillin/clavulanic acid (2000/125 mg twice daily) against 9172 respiratory isolates collected worldwide in 2000. | a new, pharmacokinetically enhanced, oral formulation of amoxicillin/clavulanic acid has been developed to overcome resistance in the major bacterial respiratory pathogen streptococcus pneumoniae, while maintaining excellent activity against haemophilus influenzae and moraxella catarrhalis, including beta-lactamase producing strains. this study was conducted to provide in vitro susceptibility data for amoxicillin/clavulanic acid and 16 comparator agents against the key respiratory tract pathogen ... | 2004 | 15494258 |
| mycoplasma pneumoniae and its role as a human pathogen. | mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. the severity of disease appears to be related to the degree to which the host immune response reacts to the infection. extrapulmonary complications i ... | 2004 | 15489344 |
| detection rates of bacteria in chronic otitis media with effusion in children. | this study was performed to investigate polymerase chain reaction-based detection of bacterial dna in middle ear fluid and assess the correlation between the pcr-positive rate with several factors associated with middle ear effusion. the purpose was to gain a further understanding of bacterial infection as a major cause of otitis media with effusion. of the 278 specimens of middle ear fluid, 39 (14%) tested positive by ordinary culture. the overall detection rate of bacterial dna using the pcr m ... | 2004 | 15483353 |
| [in vitro antibacterial activity of cefdinir against isolates of respiratory tract pathogens in children]. | to study the in vitro antibacterial activity of cefdinir against clinical isolates of respiratory tract pathogens in children. | 2004 | 15482675 |
| [cross-reactions between the antigens of healthy pulmonary tissue and moraxella catarrhalis]. | the study of cross-reactions between healthy pulmonary tissue antigens and moraxella catarrhalis with the use of sds-electrophoresis and immunoblotting revealed that in the component of healthy pulmonary tissue with a mol. wt. of 40 kd epitopes existed to which antibodies were produced, capable of cross reaction with the components of m. catarrhalis with a mol. wt. of 35 kd and 70 kd. in addition, the presence of cross-reactions between cytokeratin-8, protein contained in healthy pulmonary tissu ... | 2004 | 15481918 |
| high prevalence of genital mycoplasmas among sexually active young adults with urethritis or cervicitis symptoms in la crosse, wisconsin. | sexually active young adults in the small college town of la crosse, wisconsin, were evaluated for conventional sexually transmitted pathogens and tested for infections with mycoplasmas. the prevalence in 65 symptomatic men or women and 137 healthy volunteers (67 men and 70 women) was compared. urine specimens from both cohorts were tested by ligase chain reaction for chlamydia trachomatis or neisseria gonorrhoeae. in addition, the urethral or cervical swabs from the symptomatic subjects were te ... | 2004 | 15472322 |
| in vitro activity of ertapenem against selected respiratory pathogens. | the in vitro activity of ertapenem was evaluated in comparison to 21 selected agents against a large collection of recently isolated respiratory tract pathogens including: 180 streptococcus pneumoniae, 100 streptococcus pyogenes, 70 haemophilus influenzae, 70 moraxella catarrhalis, 100 methicillin-susceptible staphylococcus aureus and 30 klebsiella pneumoniae. additional in vitro tests (time-kill curves with ertapenem alone and in combination with four other agents) for s. pneumoniae were carrie ... | 2004 | 15472001 |
| prulifloxacin. | prulifloxacin, the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent. after absorption, prulifloxacin is metabolised by esterases to ulifloxacin. the drug has a long elimination half-life, allowing once-daily administration. ulifloxacin is generally more active in vitro than other fluoroquinolones against a variety of clinical isolates of gram-negative bacteria, including community and nosocomial isolates of escherichia coli, klebsiella spp., proteus, providenc ... | 2004 | 15456336 |
| pneumococcal vaccination does not affect the genetic diversity of moraxella catarrhalis isolates in children. | 2004 | 15449099 | |
| [18f]ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans. | the biodistribution and pharmacokinetics of the fluorine-18-labeled fluoroquinolone antibiotic [(18)f]ciprofloxacin in tissue were studied noninvasively in humans by means of positron emission tomography (pet). special attention was paid to characterizing the distribution of [(18)f]ciprofloxacin to select target tissues. healthy volunteers (n = 12) were orally pretreated for 5 days with therapeutic doses of unlabeled ciprofloxacin. on day 6, subjects received a tracer dose (mean injected amount, ... | 2004 | 15388445 |
| antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibiotics. | nocathiacins are cyclic thiazolyl peptides with inhibitory activity against gram-positive bacteria. bms-249524 (nocathiacin i), identified from screening a library of compounds against a multiply antibiotic-resistant enterococcus faecium strain, was used as a lead chemotype to obtain additional structurally related compounds. the mic assay results of bms-249524 and two more water-soluble derivatives, bms-411886 and bms-461996, revealed potent in vitro activities against a variety of gram-positiv ... | 2004 | 15388422 |
| the emerging pathogen moraxella catarrhalis interacts with complement inhibitor c4b binding protein through ubiquitous surface proteins a1 and a2. | moraxella catarrhalis ubiquitous surface protein a2 (uspa2) mediates resistance to the bactericidal activity of normal human serum. in this study, an interaction between the complement fluid phase regulator of the classical pathway, c4b binding protein (c4bp), and m. catarrhalis mutants lacking uspa1 and/or uspa2 was analyzed by flow cytometry and a ria. two clinical isolates of m. catarrhalis expressed uspa2 at a higher density than uspa1. the uspa1 mutants showed a decreased c4bp binding (37.6 ... | 2004 | 15383594 |