Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| structure of a hinge-bending bacteriophage t4 lysozyme mutant, ile3-->pro. | the mutant t4 phage lysozyme in which isoleucine 3 is replaced by proline (i3p) crystallizes in an orthorhombic form with two independent molecules in the asymmetric unit. relative to wild-type lysozyme, which crystallizes in a trigonal form, the two i3p molecules undergo large hinge-bending displacements with the alignments of the amino-terminal and carboxy-terminal domains changed by 28.9 degrees and 32.9 degrees, respectively. the introduction of the mutation, together with the hinge-bending ... | 1992 | 1404394 |
| longitudinal study of parotid saliva in hiv-1 infection. | parotid flow rate and chemistry of 78 hiv + gay/bisexual men and 27 hiv-gay/bisexual controls were compared on a longitudinal basis at 4-month intervals over a 1 yr period for changes indicative of inflammatory or autoimmune diseases of the salivary glands, or reduced protective capacity toward oral opportunistic infection. parotid saliva was examined for concentrations of sodium, chloride, phosphate, total protein, lysozyme, lactoferrin, secretory iga, salivary peroxidase, histatin and albumin. ... | 1992 | 1403836 |
| histomorphological and immunohistochemical evidence that human nodular goiters grow by episodic replication of multiple clusters of thyroid follicular cells. | this study was aimed at dissecting the cellular mechanisms that underly the growth of actively expanding human goiter nodules. thirty-two nodules from different patients, all removed because of steady recent growth, were serially sectioned and screened for 1) histomorphological signs of cell proliferation and 2) in situ expression of the immunohistochemically stained p21ras protooncogene product. bovine, porcine, and rat thyroid glands (the latter from both t4- and perchlorate-treated animals) w ... | 1992 | 1400886 |
| epithelial hyperplasia and decreased colloid content of the thyroid gland in triiodothyronine-predominant graves' disease. | patients with t3-predominant graves' disease have an increased serum t3 level despite a normal or even lower level of serum t4 caused by antithyroid drug treatment. this study investigated the morphological characteristics of the thyroid gland in this type of hyperthyroidism. ultrasound showed a similar thyroid echogenicity in both t3-predominant and ordinary graves' disease, but thyroid weight was significantly greater in t3-predominant graves' disease than in the controls [91 +/- 37 g vs. 48 + ... | 1992 | 1400885 |
| cloning and in vitro expression of the human selenoprotein, type i iodothyronine deiodinase. | the type i 5' iodothyronine deiodinase (5' di) catalyzes the deiodination of t4 to the biologically active hormone t3 and accounts for a significant fraction of its production. we have recently cloned the complementary dna (cdna) for the rat 5' di, which contains the rare amino acid selenocysteine, and used this to screen human liver and kidney cdna libraries to identify a human 5' di cdna clone. from these, we constructed a cdna encoding a functional 5' di. the 2222 base pair human 5' di cdna i ... | 1992 | 1400883 |
| bromocriptine and triac therapy for hyperthyroidism due to pituitary resistance to thyroid hormone. | although a number of patients with generalized resistance to thyroid hormone have been treated with bromocriptine (brc), only one previously reported patient with nontumoral tsh-mediated hyperthyroidism, presumably due to pituitary resistance to thyroid hormone (prth), has been successfully treated with bromocriptine (brc). in addition, several studies suggested that the t3 analog 3,5,3'-triiodothyroacetic acid (triac) may control hyperthyroidism in patients with prth. in the current study a pat ... | 1992 | 1400873 |
| method for the quantitation of iodothyronines in body tissues and fluids using high-performance liquid chromatography. | the separation and quantitation of iodotyrosines and iodothyronines [3-monoiodo-l-tyrosine, 3,5-diiodo-l-tyrosine, 3,5-, 3,3' and 3',5'-diiodo-l-tyronines, 3,5,3'-triiodo-l-thyronine (t3), reverse 3,3',5'-triiodo-l-thyronine and 3,3',5,5'-tetraiodo-l-thyronine (t4)] from animal tissues (brain, liver and serum) by a new high-performance liquid chromatographic (hplc) method is described. rats were infused with iso-osmotic sodium chloride containing 100 microm phloretin to block deiodination. the t ... | 1992 | 1400741 |
| sequence and characterization of the bacteriophage t4 comc alpha gene product, a possible transcription antitermination factor. | we have sequenced a 1,340-bp region of the bacteriophage t4 dna spanning the comc alpha gene, a gene which has been implicated in transcription antitermination. we show that comc alpha, identified unambiguously by sequencing several missense and nonsense mutations within the gene, codes for an acidic polypeptide of 141 residues, with a predicted molecular weight of 16,680. we have identified its product on one- and two-dimensional gel systems and found that it migrates abnormally as a protein wi ... | 1992 | 1400206 |
| the prognostic significance of race and survival from prostate cancer based on patients irradiated on radiation therapy oncology group protocols (1976-1985). | a number of studies have identified race as a prognostic factor for survival from prostate cancer. to evaluate the prognostic significance of race in a controlled setting, we evaluated 1294 patients treated on three prospective randomized trials conducted by the radiation therapy oncology group between 1976 to 1985. one-hundred and twenty (9%) of the patients were coded as black, while 1077 (83%) of the patients were coded as white. protocol 7506 included 607 patients with clinical stage t3-t4nx ... | 1992 | 1399729 |
| prognostic significance of pelvic recurrence and distant metastasis in prostate carcinoma following definitive radiotherapy. | this report is a retrospective analysis of 317 patients with recurrent prostate carcinoma, following definitive radiation therapy to 738 patients with histologically confirmed, clinical stage t1b-t4(a2-d1) adenocarcinoma of the prostate. seventy-four patients (10%) experienced pelvic recurrence only; 100 (13%) both pelvic recurrence and distant metastasis, while 143 (20%) developed distant metastasis only. the diagnosis of prostate recurrence was histologically confirmed in 92/174 (53%), while i ... | 1992 | 1399726 |
| growth and behavior of thyroid-deficient lizards (sceloporus undulatus). | this study investigates thyroid control of growth and energy metabolism plus growth-dependent and growth-independent behavioral effects of thyroid manipulation in lizards. experiments were done on surgically thyroidectomized (tx) and sham-operated (sh) yearling sceloporus undulatus enclosed in their natural habitat. lizards were placed in an outdoor enclosure in early august. growth rate was measured and behavior was observed until mid-october. subsequently, lizards were returned to the lab for ... | 1992 | 1398024 |
| inhibition of protein kinase c antagonizes in vitro tadpole tail fin regression induced by thyroxine. | tail fin regression can be induced in anuran amphibians with l-thyroxine (t4). this regression can be antagonized with prolactin (prl). previous work had suggested that protein kinase c (pkc) was involved in prl action. to address this issue further, the effect of a potent and selective inhibitor of protein kinase c on in vitro tail fin regression was investigated. t4-induced regression of tail fin pieces from rana pipiens tadpoles could be antagonized by adding prl or the pkc inhibitor h-7 to t ... | 1992 | 1398014 |
| characterization of a sustained-release estrogen implant on oviduct development and plasma ca concentrations in broiler breeder chicks: modulation by feed restriction and thyroid state. | the effect of estradiol-17 beta (e2) given as a sustained-release implant (compudose 200) on concentrations of plasma calcium (ca) and the development of the chick shell gland has been investigated in food-restricted and thyroid hormone-treated 6- to 8-week-old broiler breeder pullets. chicks implanted with 0, 0.5, 1.0, 1.5, 2.0, and 3.0 compudose pellets for 24 days (n = 6/group) revealed a dose-response relationship between plasma e2 and ca and on oviduct growth. plasma e2 concentrations were ... | 1992 | 1398007 |
| [identification of a 3' splice site mutation in the thyroglobulin gene in a case of congenital familial goiter]. | a case of congenital familial goiter with impaired thyroglobulin (tg) synthesis has been reported. the patient is the fifth in a family of six children, three of whom have a goiter. the parents are cousins. the patient's thyroid function tests showed low t4 (1.0 microgram g/dl) and free t4 (0.2 ng/dl), normal or slightly increased t3 (1.8 ng/ml) and free t3 (7.4 pg/ml), and high tsh (57 micrograms u/ml). serum tg was 5.1 ng/ml (normal less than 30). the thyroidal 123i-uptake was 59.8% before and ... | 1992 | 1397384 |
| [biology of trophoblast and its endocrinological profiles]. | the trophoblast of human placenta is composed of syncytiotrophoblast (s-cell) and cytotrophoblast (c-cell). c-cell displays proliferative properties, while s-cell displays little potential for proliferation. a close similarity between cytologic localization of myc product and [3h]thymidine labeling suggests that myc expression is linked to trophoblast proliferation. in situ hybridization with cdna probes revealed that mrna expression of hcg alpha and hcg beta are initiated before syncytial forma ... | 1992 | 1397383 |
| effects of selenium deficiency on thyroid hormone economy in rats. | in selenium-deficient rats, peripheral t4 to t3 conversion is markedly decreased due to the loss of the selenoprotein, type i iodothyronine 5'-deiodinase (5'd-i). despite the marked increase in circulating t4 that results from this loss of 5'd-i, serum t3 concentrations in selenium-deficient rats remain in the normal range. to determine the physiological mechanism(s) that maintains circulating t3 when peripheral t4 to t3 conversion is impaired, we examined the interrelationships between selenium ... | 1992 | 1396324 |
| thyroxine sulfate is a major thyroid hormone metabolite and a potential intermediate in the monodeiodination pathways in fetal sheep. | t3 and rt3 production rates in the fetus account for roughly only a third of the total t4 production rate; thus, the fate of the majority of t4 produced in the fetus is unknown (the "t4 disposal gap"). we developed sensitive and specific t4 sulfate (t4s) and t3 sulfate (t3s) rias to investigate the roles of these compounds in fetal t4 metabolism. t3, t4, t3s, and t4s were determined in a variety of tissue fluid and/or serum samples obtained from fetal, newborn (n = 6), and adult (n = 6) sheep. f ... | 1992 | 1396320 |
| a study of metabolism of deaminated and sulfoconjugated iodothyronines by rat placental iodothyronine 5-monodeiodinase. | the interaction of the rat placental type iii iodothyronine 5-monodeiodinase (5-md) with acetic acid (aa), propionic acid (pa), and sulfoconjugate (sa) derivatives of thyroid hormones has been investigated in comparison with hepatic iodothyronine type i md. pa and aa derivatives of both t3 and t4 were potent inhibitors of 5-monodeiodination of [125i]t3 by rat placental microsomes. 3,5,3'-triiodothyroacetic acid (t3aa) and 3,5,3'-triiodothyropropionic acid (t3pa) were comparable to t3 in their ab ... | 1992 | 1396315 |
| induction of type iii deiodinase activity in astroglial cells by thyroid hormones. | the type iii deiodinase (d-iii) activity in astroglial cells is induced by multiple pathways activated by camp, 12-o-tetradecanoylphorbol-13-acetate (tpa), and fibroblast growth factors (fgfs). this study examines the effects of thyroid hormones on d-iii activity in astroglial cells with or without induction by these factors. addition of 10 nm t3 to the culture medium caused a slow increase in d-iii activity, which reached a plateau after 48 h. this increase was concentration dependent (maximal ... | 1992 | 1396314 |
| [goiter epidemiology in south tirol]. | to ascertain the prevalence of goitre among schoolchildren in south tyrol (uncontrolled voluntary iodine salt prophylaxis), the size of the thyroid gland was determined by palpation and ultrasound in 1,013 of 1,224 children, aged 6 to 14 years (547 boys, 466 girls), selected by statistically criteria. at the same time, to assess thyroid function, total and free fractions of t3 and t4, and tsh were measured, while iodine supply was determined by measuring urinary iodine. stage ia goitre was diagn ... | 1992 | 1396136 |
| disturbance of plasma thyroid hormone levels after experimental liver transplantation. is there an association with primary graft nonfunction? | it has been suggested recently that preoperative plasma thyroid hormone levels may be used to predict the success of liver transplantation in prospective recipients and also perhaps that postoperative levels may be used to identify rejection. in the present study of unimmunosuppressed porcine recipients of liver allografts, two groups of animals were identified--those that died within five days postoperatively and the other group that were longer survivors. on the first postoperative day plasma ... | 1992 | 1395995 |
| [varicella-zoster virus-associated spinal myoclonus without skin lesions]. | a 50-year-old woman was admitted to our hospital because of abnormal involuntary movement of upper abdomen. three months before admission, she had suffered from left lateral chest pain without skin lesions for one week. the neurological examination on admission revealed myoclonus of upper abdomen, and hyperalgesia and thermohyperesthesia from t4 to t9. there was no weakness, the tendon reflexes were symmetrical and the plantar responses were flexor. the surface emg disclosed the symmetrical, syn ... | 1992 | 1395336 |
| [the role of peripheral c afferent fiber in electroacupuncture analgesia]. | experiments were carried out in rats anaesthetized with urethane (1 g/kg). late discharges of spinal dorsal horn neurons were recorded as noxious responses to strong stimulation of right tibial nerve (a train of 3 pulses, 25v, 1ms). left st.36 and sp.6 were stimulated electrically (100hz, 3v or 6v, 1ms). left sciatic nerve was exposed and soaked for 15 min in 1.5% capsaicin or vehicle 24 hours before experiment. left femoral nerve was sectioned. spinal cord was transected at t4 level in spinal r ... | 1992 | 1394957 |
| [chemical synthesis and cloning of plasmodium falciparum 45 peptide antigen gene]. | we have synthesized a 162 bp gene of human plasmodium falciparum hybrid peptide antigen by the solid-phase phosphoramidite method with abi 381a dna synthesizer. the gene encodes three fragments of the relative molecules 83 kda, 55 kda and 35 kda merozoite-specific proteins and two cs repeats or four peptides. the gene with the designed two cohesive ends was divided into 8 fragments to be synthesized. all synthetic fragments were annealed and ligated with t4 dna ligase to form double dna chain. t ... | 1992 | 1394913 |
| intra-arterial adriamycin chemotherapy in combination with radiotherapy for advanced bladder cancer. | a total of 38 patients with locally advanced bladder cancer (t2, n = 14; t3, n = 14; t4, n = 10) were treated with intra-arterial adriamycin chemotherapy in combination with radiotherapy. the clinical as well as the pathological efficacy of this treatment was evaluated in all patients. clinically, 23 (60.5%) of the 38 patients achieved a complete remission (cr), 12 (31.6%) achieved a partial remission (pr), and 3 (7.9%) remained stable (nc). the pathological efficacy was evaluated according to t ... | 1992 | 1394817 |
| changes in levels of thyroid hormones and tsh in acute myocardial infarction. | the changes in levels of total serum thyroxine (t4), total serum triiodothyronine (t3), effective thyroxine ratio (etr), and serum tsh were investigated in 88 patients with acute myocardial infarction (ami). the t4 and t3 values decreased significantly on the third day of hospitalization to return to starting values on the 7th day. etr values were significantly reduced on the 3rd day and remained so also on the 7th day. compared to starting values, serum tsh levels were increased on the 7th day ... | 1992 | 1393632 |
| the relationship between lymph node metastases and dna-ploidy status as prognostic factors in invasive breast cancer. | we evaluated the relationship between the regional lymph node metastases and the dna ploidy status in 207 patients with invasive breast cancer, as well as their prognostic values in estimating the prognosis of breast cancer. a significantly higher incidence of aneuploidy was found in patients with a large t3 or t4 tumor, a positive axillary lymph node status, more than 4 positive axillary lymph nodes or positive internal mammary lymph nodes. in a univariate study, the overall survival was signif ... | 1992 | 1392324 |
| [effects of chronic experimental stress and endogenous opioids on histophysiological parameters of the thyroid gland]. | in adult rabbits stress was modelled by electrostimulation of the hypothalamus ventromedial nucleus (15-hour-long session during 30 days) and medulla's raphe big nucleus which is one of the central places of the opioid peptides synthesis was irritated. it is revealed, that under stress thyroid gland responds by serum t3 increase in comparison with control animals with statistically significant variability of the t4 profile. chronicity of the emotional agitation involves destructive changes in th ... | 1992 | 1391858 |
| [the demonstration and staging of bladder carcinoma. a comparative study between magnetic resonance tomography, computed tomography and radioimmunoscintigraphy]. | the purpose of the present study was to compare the effectiveness of mri, ct and radioimmunoscintigraphy in the staging and detection of bladder cancers in 28 patients. we distinguish two groups: group i included the tumour stages cis-t3a and the second group the deep infiltrative tumours t3b-t4. mri was slightly superior to ct in respect of tumour staging (75% correct results as compared to 63%). no understaging occurred with mri, whereas in 22% of the cases the stage of the tumour was underest ... | 1992 | 1391837 |
| studies of dna dumbbells. i. melting curves of 17 dna dumbbells with different duplex stem sequences linked by t4 endloops: evaluation of the nearest-neighbor stacking interactions in dna. | seventeen dna dumbbells were constructed that have duplex sequences ranging in length from 14 to 18 base pairs linked on the ends by t4 single-strand loops. fifteen of the molecules have the core duplexes with the sequences 5'g-t-a-t-c-c-(w-x-y-z)-g-g-a-t-a-c3', where (w-x-y-z) represents a unique combination of a.t, t.a, g.c, and c.g base pairs. the remaining two molecules have the central sequence (w-x-y-z) = a-c and a-c-a-c-a-c. these duplex sequences were designed such that the central seque ... | 1992 | 1391634 |
| mental and physical state in subclinical hyperthyroidism: investigations in a normal working population. | we investigated whether subclinically hyperthyroid individuals selected from a nonpatient working population exhibit similar impairments to those found in studies with patients. sixteen subclinically hyperthyroid subjects without apparent reason (sh-0) and 15 subclinically hyperthyroid subjects on levothyroxine (sh-t4) were compared with 27 euthyroid controls with respect to signs and symptoms of hyperthyroidism, sleep, depressivity, ability to concentrate, anxiety, and other dimensions of well- ... | 1992 | 1391296 |
| [thyroid hormone conjugates with rhodamine b as fluorescent ligands of human plasma transport proteins]. | conjugates of thyroxine (t4) and triiodothyronine (t3) with rhodamine b in which the hormone and the fluorescent dye are linked via a thiourea bond have been synthesized. these conjugates possess an ability to inhibit in a competitive manner the binding of [125i]t4 to three protein preparations: t4-binding globulin (tbg), apolipoprotein a-i (apoa-i), and high density lipoprotein particles (apoa-i-hdl) isolated from human serum by t4-sepharose 4b chromatography and further purified. the following ... | 1992 | 1391226 |
| [the role of terminal dna groups in the activation of (adp-ribose)polymerase]. | some peculiarities of activation of (adp-ribose) polymerase by dna fragments were studied. dna fragments were produced by the digestion of calf thymus dna by micrococcal nuclease and with a subsequent enzymatic modification of their end groups by nuclease s1, polynucleotide kinase of phage t4 and alkaline phosphatase. the dependence of the activating effect of dna on the chemical structure of its end groups was established. it was shown that the terminal phosphate groups are involved in the form ... | 1992 | 1391206 |
| structure and function of the bacteriophage t4 dna polymerase holoenzyme. | 1992 | 1390652 | |
| sex hormone binding globulin (shbg) in children with obesity. | serum sex hormone binding globulin (shbg) concentration of children with obesity was measured and relationships between shbg level and body mass index (bmi), waist hip ration (whr), serum insulin, c-peptide, thyroid hormones (thyroxine--t4, triiodothyronine--t3/ sexual hormones (testosterone--t, oestradiol--e2) were investigated. significant negative correlations were found between shbg concentration and bmi, serum insulin, c-peptide concentration; significant positive concentrations were found ... | 1992 | 1389319 |
| mivacurium chloride: a study to evaluate its use during propofol-nitrous oxide anaesthesia. | we assessed the neuromuscular and cardiovascular effects of mivacurium chloride, a neuromuscular blocking agent, in 33 patients during propofol-nitrous oxide anaesthesia. neuromuscular function was assessed with supramaximal stimuli of the ulnar nerve, using surface electrodes at the wrist, with repeat trains of four. mivacurium given as a bolus of 0.15 mg.kg-1 (ed95 x 2) was found to be haemodynamically stable. intubating conditions assessed at 2 and 2.5 min were either good or excellent. all p ... | 1992 | 1387765 |
| [cancer of the breast at the time of diagnosis. a national canam study: analysis of 3007 cases]. | between april 1988 and february 1990, 3,007 cases of female breast cancer were recorded among people insured by canam*; 118 cancers were bilateral from the start and 2,889 were unilateral. at the time of diagnosis the patients' age ranged from 24 to 101 years (median: 60 years), and 35.6 percent of the tumours were virtually subclinical. lymph node involvement was clinically absent in 75 percent of the cases and histologically absent in 57 percent. in women under 50 the proportion of small to-t1 ... | 1992 | 1387214 |
| impaired atrial natriuretic factor systemic clearance contributes to its higher levels in uremia. | to evaluate the interaction between plasma levels and the systemic uptake of atrial natriuretic factor (anf) with thyroid hormone levels during acute renal failure (arf), seven groups of rats were analyzed: group 1, controls (c); group 2, arf; group 3, filtering kidney with uremia; group 4, arf with thyroxine (t4) supplement (arf + t4); group 5, thyroidectomy (tx); group 6, arf on tx rats (tx + arf); group 7, tx + arf supplemented with t4 (tx + arf + t4). plasma creatinine (cr), urea, t4, blood ... | 1992 | 1386758 |
| treatment of hypothyroidism reduces low-density lipoproteins but not lipoprotein(a). | lipoprotein(a) [lp(a)] is a low-density lipoprotein (ldl) particle in which apolipoprotein b-100 (apo b) is attached to a large plasminogen-like protein called apolipoprotein(a) [apo(a)]. apo(a) has several genetically determined phenotypes differing in molecular weight, to which lp(a) concentrations in plasma are inversely correlated. ldl and apo b levels are often elevated in untreated hypothyroidism and lowered by thyroxine (t4) treatment, probably due to an increase in ldl receptors. we meas ... | 1992 | 1386404 |
| prediction of pelvic lymph node metastases by a prostate-specific antigen and prostatic acid phosphatase in clinical t3/t4m0 prostatic cancer. | prostate-specific antigen (psa) and prostatic acid phosphatase (pap) were determined in the serum of 69 patients with clinical t3/t4m0 prostatic cancer before staging lymphadenectomy. in principle, high-dose radiotherapy was given only to patients of pathological n0 category. seventeen patients had a prelymphadenectomy psa level below the normal upper reference limit (10 micrograms/l) and only 3 of them had pelvic lymph node metastases. fifteen of 52 patients with a preoperative psa level > or = ... | 1992 | 1385143 |
| thyroid physiology impairment by malathion in the freshwater catfish clarias batrachus. | effects of malathion on serum and glandular thyroxine (t4), triiodothyronine (t3), the t3/t4 ratio, peroxidase activity, and extrathyroidal conversion of t4 to t3 have been studied in the freshwater catfish clarias batrachus during the prespawning and spawning phases of its annual reproductive cycle. malathion inhibited t4 secretion in the kidney, but accelerated t4 synthesis in the pharyngeal thyroid. this pesticide also inhibited the extrathyroidal conversion of t4 to t3 in serum during both t ... | 1992 | 1385075 |
| description of a variably expressed and labile epitope of thyroglobulin and its occurrence in different thyroid diseases using a monoclonal antibody. | a new category of epitopes of human thyroglobulin is being described defined by a monoclonal antibody (tutg 1). the epitope shows a very variable expression in normal individuals as well as in different thyroid diseases. according to gel filtration data the epitope is located at the intact molecule and is very sensitive to tryptic digestion. the monoclonal antibody was used in an irma system for plasma measurements in the follow-up of thyroid cancer patients. in individuals with high epitope exp ... | 1992 | 1385030 |
| adjuvant cytostatic therapy of breast cancer as an important factor in the postponing of a relapse and longer survival period. | this prospective clinical study shows the results of the adjuvant cytostatic therapy (act) in breast cancer applied to patients in the premenopausal age. cyclophosphamide, methotrexate, 5-fluorouracil (cmf) group (70 patients): after operative and radiotherapeutic treatment the act is applied over the period of six months (six cycles). control group (71 patients): only operative and radiotherapeutic treatment. protocol of the act: cyclophosphamide, methotrexate, 5-fluorouracil (cmf) over 5 days ... | 1992 | 1384832 |
| the role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. | selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (t4) to the more metabolically active 3,3'-5 triiodothyronine (t3). hepatic type i iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [125i]n-bromoacetyl reverse triiodothyronine, is also labeled with 75se by in vivo treatment of rats with 75se-na2seo3. thus, the type i iodothyronine 5'-deiodi ... | 1992 | 1384621 |
| [the effect of renal artery embolization on the results of treating kidney cancer patients]. | to analyze the prognosis, 401 renal cancer cases were examined retrospectively and prospectively. there were 157 females and 244 males. preoperative embolization of the renal artery resulted in longer survival: in stage t3 it increased from 44 to 60%, in stage t4 from 7 to 50%. after palliative nephrectomy the patients' mean survival reached 10.6 months against 16 months following palliative embolization of the kidney. palliative embolization is thought the most effective intervention in inopera ... | 1992 | 1384217 |
| the distribution of uv damage in the laci gene of escherichia coli: correlation with mutation spectrum. | we have determined the uv (254 nm) damage distribution in the transcribed and non-transcribed strands of the i-d region of the escherichia coli laci gene. the locations of replication blocking lesions were revealed as termination sites of t7 dna polymerase and/or t4 dna polymerase 3'-5' exonuclease. termination products, i.e. both cyclobutane pyrimidine dimers and 6-4 photoproducts, were resolved and analysed on an automated dna sequencer. these two major photoproducts are not randomly distribut ... | 1992 | 1383713 |
| substance p immunoreactive boutons form synapses with feline sympathetic preganglionic neurons. | in this study, the relationship between substance p-immunoreactive boutons and antidromically activated sympathetic preganglionic neurons was examined by light and electron microscopy. sympathetic preganglionic neurons in the t2-t4 spinal segments of the cat were identified by intracellular recording and antidromic activation from the corresponding white ramus. neurons were filled with lucifer yellow and then stained to reveal, simultaneously, substance p and lucifer yellow immunoreactivity. all ... | 1992 | 1383281 |
| [results of treatment in esophageal cancer]. | 204 patients were treated for esophageal cancer from 1.1.1986 until 1.6.1992 (carcinoma of the hypopharynx: n = 12, adenocarcinoma of the endobrachyesophagus: n = 82, primary esophageal cancer: n = 110). out of the primary esophageal cancers 84 tumors (76%) were resected and 24% had palliative endoscopic and/or irradiation therapy. the stage distribution of the resected patients was: stage i: 7.1%, stage iia: 35.7%, stage iib: 11.9%, stage iii: 33.3%, stage iv: 11.9%. the total morbidity of the ... | 1992 | 1382923 |
| mammary gland differentiation in hypophysectomized, pregnant mice treated with corticosterone and thyroxine. | swiss webster mice were hypophysectomized or sham-operated on day 11 of pregnancy. the animals were fitted s.c. with osmotic minipumps containing either corticosterone (b) dissolved in molecusol (pharmatec, alachua, fl) or the vehicle alone immediately after they were hypophysectomized. animals in some of the experimental groups also received thyroxine (t4) in their drinking water. the mice were killed on day 18 of gestation, and mammary tissue was homogenized and extracted for assessment of dna ... | 1992 | 1382632 |
| alternating chemo-radiotherapy with cisplatin and 5-fluorouracil plus bleomycin by continuous infusion for locally advanced undifferentiated carcinoma nasopharyngeal type. | more than 80% of undifferentiated carcinoma nasopharyngeal type patients with n3 disease (ajc-uicc 1987) will die with or from distant metastases within 3 years after the first symptom. from february 1986 to november 1987 30 consecutive patients with very advanced local disease were entered in a programme with chemotherapy-radiotherapy (ct-rt) alternation after a thorough work-up to eliminate the possibility of distant metastases. protocol: two cycles of cisplatin 100 mg/m2 day 1, bleomycin 15 m ... | 1992 | 1382499 |
| sites of action of 2-thiazoline-2-thiol on biogenesis of thyroid hormones. | 2-thiazoline-2-thiol is an antithyroid agent that strongly reduces thyroid hormone levels. synthesis of these hormones is catalyzed in vivo by thyroid peroxidase. the interaction of this drug with molecular iodine and its effect on peroxidase activity were investigated. iodine and 2-thiazoline-2-thiol form a complex of the charge transfer type of 1:1 stoichiometry characterized by a formation constant of 2,527 l.mole-1 at 20 degrees c. this drug was found to inhibit both horseradish peroxidase a ... | 1992 | 1380999 |
| cell cycle progression in denv-transfected murine fibroblasts exposed to ultraviolet radiation. | repair-proficient murine fibroblasts transfected with the denv gene of bacteriophage t4 repaired 70-80% of pyrimidine dimers within 24 h after exposure to 150 j/m2 ultraviolet radiation (uvr) from an fs-40 sunlamp. under the same conditions, control cells repaired only about 20% of uvr-induced pyrimidine dimers. after uvr exposure, both control and denv-transfected cells exhibited some degree of dna-synthesis inhibition, as determined by flow cytometric analysis of cell-cycle kinetics in propidi ... | 1992 | 1380650 |
| amiodarone decreases cardiac beta-adrenoceptors through an antagonistic effect on 3,5,3' triiodothyronine. | because surprising similarities exist between the cardiac effects of amiodarone and those observed during hypothyroidism, we tested three different mechanisms of action in rats to determine whether amiodarone might act by inducing a tissular hypothyroidism: (a) a decrease in thyroid secretion, (b) an inhibiting effect on the conversion of thyroxine (t4) to 3,5,3' triiodothyronine (t3), and (c) a direct antagonistic effect on the cellular action of t3. five groups of rats, treated orally for 7 or ... | 1992 | 1380587 |
| insulin-like growth factor binding protein expression in the hypothyroid rat is age dependent. | thyroid hormone is essential for normal growth and development. for certain t4 effects, there is a critical period during ontogeny when normal t4 levels are required, and thyroid replacement after that period cannot correct the changes in hypothyroid animals. we have previously described a prolonged high expression of serum insulin-like growth factor binding protein (igfbp)-2 during the perinatal period in congenitally hypothyroid rats. to see if this effect was confined only to a certain period ... | 1992 | 1380443 |
| the sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry. | the sympathetic and sensory innervation of guinea-pig trachea and lung were studied by means of retrograde neuronal tracing using fluorescent dyes, and double-labelling immunofluorescence. sympathetic neurons supplying the lung were located in stellate ganglia and in thoracic sympathetic chain ganglia t2-t4; those supplying the trachea resided in the superior cervical and stellate ganglia. retrogradely labelled sympathetic neurons were usually immunoreactive to tyrosine hydroxylase; the majority ... | 1992 | 1380140 |
| risk factors for developmental disorders in infants born to women with graves disease. | to identify risk factors for disorders of fetal growth and thyroid function in the presence of maternal graves disease. | 1992 | 1379702 |
| adult rat brain is sensitive to thyroid hormone. regulation of rc3/neurogranin mrna. | the mammalian brain is considered to be poorly responsive to thyroid hormone after the so called "critical periods" of brain development, which occur in the rat before postnatal days 15-20. in a previous work (muñoz, a., a. rodriguez-peña, a. perez-castillo, b. ferreiro, j.g. sutcliffe, and j. bernal. 1991. mol. endocrinol. 5:273-280) we have identified one neuronal gene, rc3, whose expression is influenced by early neonatal hypothyroidism and thyroid hormone treatment. in the present work we sh ... | 1992 | 1379612 |
| the role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. | selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (t4) to the more metabolically active 3,3'-5 triiodothyronine (t3). hepatic type i iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [125i]n-bromoacetyl reverse triiodothyronine, is also labeled with 75se by in vivo treatment of rats with 75se-na2seo3. thus, the type i iodothyronine 5'-deiodi ... | 1992 | 1379458 |
| effect of in vivo administration of recombinant acidic fibroblast growth factor on thyroid function in the rat: induction of colloid goiter. | we have recently demonstrated that the iv administration of 0.6-60 micrograms/kg.day of acidic fibroblast growth factor (acidic fgf) increases thyroid weight in male and female rats. interestingly, measurement of serum tsh and thyroid hormones in rats treated with 6 micrograms/kg.day acidic fgf for 30 days revealed only a slight increase in serum t4 and reverse t3 concentrations. since thyroid function was only examined 24 h after the 30th daily treatment, we performed a series of experiments to ... | 1992 | 1379163 |
| [successful treatment of hyperthyroidism simulating acute abdomen and psychosis]. | a 49 years old female patient entered the surgical department because of epigastric and ileocoecal pains with the symptoms of acute abdomen. a surgical intervention was performed because of supposed appendicitis, but it was not verified. during the surgical observation the patient was confused and negativistic so she was transferred to the psychiatric department. because of loss of 20 kg weight, high blood sedimentation and anaemia she was sent to our department with the suspicion of an organic ... | 1992 | 1378958 |
| in vitro expression of thyroxine-binding globulin (tbg) variants. impaired secretion of tbgpro-227 but not tbgpro-113. | thyroxine-binding globulin (tbg) is a glycoprotein that transports thyroid hormones in blood. of two naturally occurring variants in man that harbor single proline substitutions (tbg-cd5 and tbg-montreal), only tbg-cd5 manifests as complete tbg deficiency. in order to determine the pathophysiology of these tbg disorders, we expressed tbg-cd5 and tbg-montreal (tbg-m), as well as the common type tbg (tbg-c) in reticulocyte lysate and xenopus oocytes. vectors encoding the three tbg types were const ... | 1992 | 1378434 |
| effects of streptozotocin diabetes on amylase release and camp accumulation in rat parotid acinar cells. | rat parotid responses to sympathetic nerve stimulation in vivo are impaired 2-4 weeks after the induction of streptozotocin diabetes. in this study, the effects of experimental diabetes of similar duration and severity on noradrenaline-stimulated amylase release and camp accumulation were examined in vitro. amylase levels were significantly lower in acinar cells isolated from diabetic animals than in controls, and cellular amylase increased after treatment of the diabetic animals with either thy ... | 1992 | 1376985 |
| uv endonuclease-mediated enhancement of uv survival in micrococcus luteus: evidence revealed by deficiency in the uvr homolog. | unlike its phage t4 counterpart (also known as endonuclease v), micrococcus luteus uv endonuclease (pyrimidine dimer dna glycosylase/apurinic-apyrimidinic endonuclease) has suffered from lack of genetic evidence to implicate it in the promotion of uv survival of the cell, i.e., mutants with its deficiency are no more uv-sensitive than the wild type. on the assumption that the contribution of uv endonuclease is obscured by the presence of a homolog of escherichia coli uvrabc endonuclease, which h ... | 1992 | 1376434 |
| dna synthesis blocking lesions induced by singlet oxygen are targeted to deoxyguanosines. | in vitro dna synthesis on single stranded templates damaged by singlet oxygen was investigated in the supf trna gene sequence, using several dna polymerases. singlet oxygen was generated by the thermal decomposition of the water soluble with the endoperoxide of disodium 3,3'-(1,4-naphthylidene) dipropionate (ndpo2). the data demonstrated that damage at deoxyguanosine residues interrupts dna polymerization. modified t7 phage and thermus aquaticus dna polymerases were found to synthesize dna fragm ... | 1992 | 1375992 |
| differential regulation by growth hormone (gh) of insulin-like growth factor i and gh receptor/binding protein gene expression in rat liver. | we have reported that female hypophysectomized (hypox) rats replaced with t4 and cortisone and treated for 7 days with gh injections (4 x 12.5 micrograms/day) had significantly greater growth and increase in serum insulin-like growth factor-i (igf-i) than did hypox rats continuously infused with gh (50 and 250 micrograms/day), whereas gh binding to liver membranes was increased only by infusion. we now report the effects of hypophysectomy, t4 and cortisone replacement, and the aforementioned con ... | 1992 | 1375898 |
| selenium content of livers from sex-linked dwarf and normal broiler breeders. influence of a thyrotropin-releasing hormone-induced growth hormone release. | plasma concentrations of cgh, t3, and t4 were not different between dwarf and normal broiler breeders. normal hens had a liver selenium content of 710 +/- 35 ng/g, and dwarf hens 656 +/- nine ng/g (n = 8). following injections into a wing vein of different doses (1.5, 3, 6, 12, and 24 micrograms/kg) of the hypothalamic hormone trh, gh was increased after 15 min. this effect seemed to last longer in dwarf chickens. plasma concentrations of t3 increased significantly 1 h after trh in normal hens, ... | 1992 | 1375067 |
| influence of thyroparathyroidectomy and thyroxine replacement on cu and zn cellular distribution and on the metallothionein level and induction in rats. | thyroid hormones are involved in copper and zinc distribution in rat tissues. we examined the influence of thyroparathyroidectomy (tpty) and of a replacement therapy by t4 on cu and zn organ distribution. mt levels were also measured both in basal conditions and after induction by cadmium. the results confirm that a lack of t4 modified cu and zn in serum and tissues. in serum, tpty increased cu (+15%) and ceruloplasmin (+18%), and decreased zn (-18%). in tissues, cu was altered in liver (+13%), ... | 1992 | 1375066 |
| iodine deficiency, other trace elements, and goitrogenic factors in the etiopathogeny of iodine deficiency disorders (idd). | severe goiter, cretinism, and the other iodine deficiency disorders (idd) have their main cause in the lack of availability of iodine from the soil linked to a severe limitation of food exchanges. apart from the degrees of severity of the iodine deficiency, the frequencies and symptomatologies of cretinism and the other idd are influenced by other goitrogenic factors and trace elements. thiocyanate overload originating from consumption of poorly detoxified cassava is such that this goitrogenic f ... | 1992 | 1375059 |
| morphological heterogeneity and phenotypical instability versus metastatic stability in the murine tumor model er 15-p. | at clinical presentation, the majority of malignant tumors are composed of multiple clonal subpopulations of tumor cells with different phenotypic characteristics. using the experimental tumor model er 15-p, a methylcholanthrene-induced pleomorphic sarcoma of the c57 bl6j mouse, we studied a system of long-term in vivo passages of this primary tumor for cell morphological changes, and alterations in the potential for spontaneous lung metastases. transplants from the primary after the 4th, 20th, ... | 1992 | 1374756 |
| molecular design of a eukaryotic messenger rna and its chemical synthesis. | a designed mrna consisting of 42 ribonucleotides having the cap structure was synthesized. the capped leader sequence of the brome mosaic virus (bmv) mrna 4, m7g5'pppguauuaaua (f-1), was synthesized by the phosphotriester method and followed by the capping reaction. a 32-mer consisting of an initiation codon (aug), the coding region corresponding to a bacterial pheromone cad1 and two stop codons, was constructed by the 18-mer (f-2) and 14-mer (f-3), which were synthesized by the phosphoramidite ... | 1992 | 1374557 |
| adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. | we intend to develop in vitro model systems to study the hormonal regulation of uncoupling protein (ucp) and its role in brown adipose tissue (bat) thermogenesis. we report here that ucp mrna responses to adrenergic and thyroid hormone manipulations in freshly dispersed, mature brown adipocytes mimic in vivo observations. studies were performed in brown adipocytes obtained from interscapular brown fat of euthyroid or hypothyroid rats. the tissue was dispersed with collagenase, and cells were iso ... | 1992 | 1374009 |
| a eukaryotic dna glycosylase/lyase recognizing ultraviolet light-induced pyrimidine dimers. | cyclobutane pyrimidine dimers (cpds) are the predominant product of photodamage in dna after exposure of cells to ultraviolet light and are cytotoxic, mutagenic and carcinogenic in a variety of cellular and animal systems. in prokaryotes, enzymes and protein complexes have been characterized that remove or reverse cpds in dna. micrococcus luteus and t4 phage-infected escherichia coli contain a specific n-glycosylase/apurinic-apyrimidinic lyase that catalyses a two-step dna incision process at si ... | 1992 | 1373868 |
| identification of metastatic disease by t category, gleason score and serum psa level in patients with carcinoma of the prostate. | pre-operative serum prostate specific antigen (tandem-r assay), t category, gleason score and the metastatic (m1) status of a consecutive series of 60 patients with newly diagnosed carcinoma of the prostate were studied prospectively. the results revealed that, of these variables, pre-operative serum psa (greater than 100 ng/ml) was the single most important indicator of metastatic disease, with 100% predictive value. with this alone, 83.3% of m1 disease could be correctly identified. for the re ... | 1992 | 1373666 |
| characterization of a neutralizing monoclonal antibody to pasteurella haemolytica leukotoxin. | six hybridoma clones producing monoclonal antibodies (mabs) reactive with pasteurella haemolytica a1 leukotoxin were derived from mice immunized with leukotoxin excised from sodium dodecyl sulfate-polyacrylamide gels. of the six mabs, only one, ltx-2, neutralized leukotoxin in a bl-3 cell cytotoxicity assay. mab ltx-2 blocked association of a1 leukotoxin to bl-3 cells, as measured by flow cytometric analysis. the epitope recognized by ltx-2 was localized to the carboxyl half of the native protei ... | 1992 | 1373398 |
| [polyneuropathy in hyperthyroidism--a clinical neurophysiologic study]. | in this prospective study, 27 patients with hyperthyroidism were evaluated neurophysiologically. there were 24 women and 3 men: the mean age was 56.4 years (range 21 to 84 years). neurologic complaints of the patients were muscle weakness (59.3%), muscle cramps (18.5%) and sensory symptoms (11.1%). tendon reflexes were increased in 18.5% and decreased in 14.8%, respectively. while the motor nerve conduction velocities (ncv) of the tibial and the peroneal nerve revealed normal results in the majo ... | 1992 | 1373252 |
| the rex system of bacteriophage lambda: tolerance and altruistic cell death. | the rexa and rexb genes of bacteriophage lambda encode a two-component system that aborts lytic growth of bacterial viruses. rex exclusion is characterized by termination of macromolecular synthesis, loss of active transport, the hydrolysis of atp, and cell death. by analogy to colicins e1 and k, these results can be explained by depolarization of the cytoplasmic membrane. we have fractionated cells to determine the intracellular location of the rexb protein and made rexb-alkaline phosphatase fu ... | 1992 | 1372278 |
| replication of adeno-associated virus type 2 in human lymphocytic cells and interaction with hiv-1. | adeno-associated virus (aav) is a nonpathogenic parvovirus which normally requires helper adenovirus or herpes-virus for replication. we examined the growth of aav type 2 in human lymphocytes and its possible interaction with hiv-1. three b cell lines (ck-b, hs-2, and uc729) and four t cell lines (molt-4, jurkat, hut78, and hut78+hiv, which is persistently infected with hiv-1) were infected with aav either in the presence or in the absence of adenovirus. aav dna was found in cells of all the lin ... | 1992 | 1372138 |
| abnormality of background eeg determined by the entropy of power spectra in epileptic patients. | relationships between epileptiform discharges and background activity were examined by power spectral entropy (pse), measuring a degree of eeg irregularity. the eegs were recorded from 10 electrodes placed at f3, f4, c3, c4, t3, t4, p3, p4, o1 and o2 in 11 epileptic patients with widespread lateralized spike and wave complexes (swcs). bipolar records were also made from the antero-posterior derivations. the locations of the maximum pse coincided with those of the maximum amplitude of swc in most ... | 1992 | 1371440 |
| hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin. | a retrospective review was done on all high volume choriocarcinomas and other germ cell tumors of men with serum beta-human chorionic gonadotropin (beta-hcg) levels greater than 50,000 miu/ml to determine the incidence and characteristics of hyperthyroidism in this setting. nineteen patients were identified with high beta-hcg levels, but because 2 did not have thyroid function tests performed, the cases of only 17 patients were evaluable. of these, 14 (82%) had primary testicular carcinoma and 3 ... | 1992 | 1371235 |
| cloning of noncultivatable human rotavirus by single primer amplification. | a novel, sequence-independent strategy has been developed for the amplification of full-length cdna copies of the genes of double-stranded rna (dsrna) viruses. using human (bristol) group c rotavirus as an example, a single amino-linked modified oligonucleotide (primer 1) was ligated to either end of each dsrna genome segment by using t4 rna ligase. following reverse transcription, annealing, and repair of cdna strands, amplification of the viral dsrna genome was accomplished by polymerase chain ... | 1992 | 1371174 |
| dermatomal somatosensory evoked potentials: cervical, thoracic, and lumbosacral levels. | somatosensory evoked potentials were recorded at the scalp to stimulation of the skin at c4, c5, c6, c7, c8, t2, t4, t6, t8, t10, t12, l2, l3, l4, l5, and s1 dermatomes and of the tibial nerve. stimulation and recording techniques are described. data were obtained from 41 normal subjects, 25 of which had all 16 dermatomes studied. wave form descriptions include both typical and atypical presentations. descriptive statistics for latency, amplitude, left to right comparisons, and level to level co ... | 1992 | 1370404 |
| identification of a cd21 receptor-deficient, non-ig-secreting peripheral b lymphocyte subset in hiv-seropositive drug abusers. | we have studied 61 hiv-seropositive heroin addicts (18 asymptomatic, 20 arc, and 23 aids cases), 26 hiv-seronegative heroin addicts, and 45 healthy blood donors, matching the groups each other for age and sex. we have focused on the phenotypic characteristics of b subpopulations in the peripheral blood of hiv-seropositive and -seronegative drug abusers, paying particular attention to the consistence of the "cd20+" b cell subset, which poorly expresses the cd21 membrane receptor for the c3d and e ... | 1992 | 1370396 |
| effects of continuous infusion of insulin-like growth factor i and ii, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat. | in this study, we examined the effects of systemically administered insulin-like growth factor (igf)-i and -ii on growth of the hypophysectomized (hx) neonatal rat. neonatal wistar rats were hx or sham hx on postnatal day (pnd) 6 and implanted sc with alzet pumps on pnd 10. recombinant human igf-i or -ii were infused between pnd 10 and 18 at an average dose of 1.9 micrograms/g body weight (bw) per day. in addition, some groups received daily sc injections of recombinant human gh or thyroxine (t4 ... | 1992 | 1370151 |
| t lymphocyte subsets in chronic uremic patients treated with maintenance hemodialysis. | blood t lymphocyte subsets have been studied using monoclonal antibodies in 10 chronic uremic patients treated with maintenance hemodialysis. both total t lymphocytes identified by the antibody okt3, and the helper-inducer t lymphocyte subset identified by the antibody okt4 were found to be significantly lower than normal. the cytotoxic-suppressor t cell subset was only moderately, even if significantly reduced, so that the t4/t8 ratio in uremic patients was significantly lower than normal. thes ... | 1990 | 1369694 |
| lysozyme expression in lactococcus lactis. | three lysozyme-encoding genes, one of eukaryotic and two of prokaryotic origin, were expressed in lactococcus lactis subsp. lactis. hen egg white lysozyme (hel) could be detected in l. lactis lysates by western blotting. no lysozyme activity was observed, however, presumably because of the absence of correctly formed disulphide bonds in the l. lactis product. the functionally related lysozymes of the e. coli bacteriophages t4 and lambda were produced as biologically active proteins in l. lactis. ... | 1992 | 1368776 |
| a novel expression system for production of a labile protein in escherichia coli by infection with cytosin-substituting t4 phage. | a novel expression system was developed for the high level production of a labile protein in escherichia coli. the regulatory signal of bacteriophage t4 uvsy gene was fused in frame with the coding region of human ventricular myosin alkali light chain (vlc1) gene. expression from the regulatory signal was enhanced and continued in a lysis-inhibition state by infection with a cytosine-substituting t4 phage mutant. vlc1 protein was produced at a low level without infection because of its instabili ... | 1991 | 1368757 |
| utilization of trans-activated t4 uvsy regulatory signal for a high yield of cloned gene products. | we established an efficient system for a high-level production of foreign gene products in escherichia coli using a trans-activated gene expression under the control of a phage t4 regulatory signal cloned in a plasmid by t4 phage infection. the transcriptional and translational signal of the t4 uvsy gene cloned in a plasmid was fused translationally with the coding region of the lacz gene. when e. coli cells carrying the uvsy-lacz plasmid were infected with cytosine-substituting t4 phage at a mu ... | 1991 | 1368756 |
| the role of hereditary factors in phenotypic variability of hormone levels in a population genetically adapted to the circumpolar environment. | the variability of plasma cortisol, t3, t4, tsh, and estradiol levels was studied in the north khanty population genetically adapted to the extreme conditions of the north. negative linear correlations of t3 and t4 levels with age were obtained. cortisol, estradiol, and t3 levels showed nonlinear age dependency. t4 concentrations were significantly lower in august than february and november. the highest heritability estimate was shown for estradiol levels (44%). the relationships between genetic ... | 1991 | 1365222 |
| [behavior of thyrotropic, triiodothyronine, thyroxine and cortisol hormone levels in blood serum of patients with duodenal ulcer treated with ranitidine]. | blood serum concentrations of thyrotropic hormone (tsh), triiodothyronine (t3), thyroxine (t4) and cortisol have been measured in 50 patients with duodenal ulcer. the determinations were repeated after a specific time of treatment with ranitidine: in 45 patients after 3 weeks and in 37 after additional 30 days of treatment. during the first period of treatment ranitidine was administered at a dose of 300 mg divided into two daily doses and during the second period of treatment at a single daily ... | 1991 | 1364490 |
| changes in serum t4, t3 and tsh concentrations in newborns and infants with congenital goiter from the mazovia region. | thyroid function was investigated in a group of 61 newborns with congenital goiter before starting the therapy with thyroid hormones. the group included 19 girls and 42 boys, of which 27 were of age not exceeding one week (group i), 19 were between the first and the second week (group ii), and 15 were between the second week and the third month of life (group iii). the concentrations of the thyroid hormones were determined by radioimmunoassay. the values obtained have been compared with the loca ... | 1991 | 1364487 |
| [laboratory tests: level of t3, t4, tsh and antithyroid gland autoantibodies in the polish population]. | in 1986-1990 epidemiologic studies on the thyroid diseases frequency in the polish population were undertaken. during this studies the serum levels of tsh, t4, t3 and autoantibodies were estimated in more than 30 thousand people. tsh was estimated in 30749, t4 in 30928, t3 in 30621 and autoantibodies in 31265 randomly chosen people in 5 districts. we have arbitrarily established the normal range for tsh to be between 0.4-3.8 microiu/ml, for t4 4.4-12.5 micrograms% and for t3 0.9-1.95 ng/ml. the ... | 1991 | 1364483 |
| [effects of prophylactic doses of potassium iodide on the course of thyroid diseases (1986-1990) diagnosed due to the atomic accident at czernobyl in adult patients at the outpatient endocrinologic hospital clinic in lodz]. | 2521 patients of the lódź outpatient endocrinological clinic (2290 females, 231 males; inhabitants of the central region of poland lódź city, lódź metropolitan area, piotrków, płock, sieradz, skierniewice and włocławek provinces in which committed dose equivalent to the thyroid was between 2.7-7.0 msv [min.-max.] in skierniewice province and 4.6-11.7 msv in płock province) were included in the study. the patients were divided into 5 groups: i--persons who did not take the protective dose of pota ... | 1991 | 1364482 |
| [influence of radioactive contamination and iodine prophylaxis after the czernobyl disaster on thyroid morphology and function of the poznan region]. | the radioactive contamination of poznań region was recognized after chernobyl accident as average. the predicted values of minimal (inhalation) and maximal (inhalation and ingestion) committed dose equivalent to the thyroid varied from 2.5 (min) to 24.7 (max) msv in different groups of adults and children. to follow up the results of iodine prophylaxis and some aspects of possible thyroid gland morphological and functional changes 11086 persons were carefully investigated clinically and biochemi ... | 1991 | 1364479 |
| [results of epidemiologic studies performed after the disaster in czernobyl among the adult part of the population in the region of krakow]. | epidemiologic studies following the czernobyl accident were performed in region kraków, including kraków, nowy sacz and kielce district. 1426 males and 2495 females were selected according to the random sample on the whole population of kraków and nowy sacz, as well as in some selected areas in swietokrzyski mountains, and in kielcecity. the aim of the study was to assess the results of the prophylaxis with kalium iodine after the radiation and the incidence of the goiter in the population. it w ... | 1991 | 1364478 |
| [epidemiologic studies after the disaster in czernobyl in the population of children in the krakow region]. | in 1989-1990 the epidemiologic studies about the impact of of czarnobyl events on the health of children in kraków and nowy sacz region were performed. the morphologic and functional changes of thyroid gland in children were estimated. almost 90% of children in both districts received the iodine preparations for prophylactic reason. the mean time of intake was between 5-10 days following the czarnobyl explosion. there were no relationship between the dose of iodine absorbed during prophylactic a ... | 1991 | 1364477 |
| [chronicled report on the period from may 1 to september 27, 1989. discussion of risk factors]. | the institute of mother and child was invited in 1988 by professor j. nauman to his chernobyl program, so as to inspect children born after chernobyl accident, particularly these born in first days following the accident dated 26 april 1986. the central part of poland is covered with screening for congenital pku and hypothyroidism therefore all children had estimated tsh-spot levels between 3rd and 5th day of life. so as to control the present state of general health and thyroid state in the stu ... | 1991 | 1364473 |
| [epidemiologic foundation for population studies of program mz-xvii]. | epidemiological foundation included: aim of studies, knowledge about epidemiology of thyroid disorders in poland, evaluation of radioiodine dose accumulated in thyroids of inhabitants of different age living in different par of poland, information about relative diet iodine deficiency in different parts of poland and identification of research teams (manpower) capable to carry on population studies. the final identification of epidemiological foundation was proceeded by pilot studies performed i ... | 1991 | 1364470 |
| graves' disease: evolution and prognosis after eight months of treatment with methimazole. | we studied 26 patients with graves' disease, from a population with sufficient iodine supply, treated with high doses of methyl mercaptoimidazole (mmi) during eight moths. we evaluated: a) their evolution after treatment withdrawal; b) the correlation between evolution and tsh-receptor antibodies (trab), thyroid hormone levels, microsomal antibodies (mab), t3/t4 index and clinical data; c) their prognosis. the patients were followed during 12-60 months, and blood samples were collected before tr ... | 1992 | 1364158 |
| [hiv infection in the child after materno-fetal transmission: early treatment with azidothymidine and prevention of secondary infectious complications]. | twenty-four perinatally hiv infected children received early treatment as soon as the diagnosis of viral contamination was established. in 13 cases (group 1), this diagnosis was based on a viremia and/or antigenemia during the first 6 months of life. in 11 cases (group 2), children were more than 15 months-old and had a positive hiv antibody test. therapy included azidothymidine (azt, 400 mg/m2/d) and the prevention of secondary infectious complications with intravenous immunoglobulin and cotrim ... | 1992 | 1364153 |
| immunization with human thyrotrophin receptor peptide induces an increase in thyroid hormone in rabbits. | eight rabbits were immunized with a synthetic peptide corresponding to the unique n-terminal region (termed n peptide; amino acid residues 29-57) in the extracellular domain of the human thyrotrophin (tsh) receptor. after 10 weeks, all of the eight rabbits produced anti-n peptide antibodies. western blot analysis revealed that the antibodies recognized rabbit tsh receptor as an approximately 100 kda protein. we compared the level of thyroid hormone in serum taken before immunization (preimmune s ... | 1992 | 1362578 |