Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| do thyroid function tests independently predict survival in the critically ill? | we studied the ability of thyroid function tests to predict hospital survival in 116 critically ill patients and compared the results with independent predictions of survival made by critical care physicians. eleven patients (9.5%) had clinically unsuspected hypothyroidism and were less likely to survive (p = 0.03). in patients critically ill with nonthyroidal disease, low t3, low ft3i, low t4, low ft4i, high tsh, and high t3u levels each showed significant correlation with nonsurvival (all p le ... | 1992 | 1525579 |
| identification of thyroxine-sulfate (t4s) in human serum and amniotic fluid by a novel t4s radioimmunoassay. | recently, we identified significant amounts of thyroxine sulfate (t4s) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids. little is known, however, about sulfate conjugation of thyroxine in humans. in this study, we employed a novel, sensitive t4s ria to address this question. the rabbit antiserum was quite specific; t4, t3, rt3, and 3,3'-t2 showed less than 0.002% cross-reactivity. other analogs cross-reacted less than 0.0001%. only rt3s and t3s cross-reacted significantly ... | 1992 | 1525576 |
| assessment of thyroid function during pregnancy. | assessment of a woman's thyroid function often is necessary during pregnancy, since either uncorrected hypothyroidism or hyperthyroidism can adversely affect pregnancy outcome. pregnancy-induced changes in thyroid hormone economy, particularly the major alterations in thyroid hormone binding to serum proteins, change the results of some commonly used thyroid hormone measurements. in vivo isotopic testing, including scintiscanning and thyroid radioiodine uptakes, cannot be used. because of advanc ... | 1992 | 1525567 |
| transport of the thyroid hormones across the feline gut wall. | intestinal absorption of radioiothyroxine (t4*) and of radiotriiodothyronine (t3*) was studied in normal cats (n = 5 for t4* and n = 6 for t3*). absorption was localized by a series of studies comparing the time-activity data for plasma and fecal t4* or t3* radioactivity after i.v. administration with data obtained in the same cats after administration by the oral, jejunal, midileal, and cecal routes. data were analyzed using a multicompartmental model to account for longitudinal gut transit, me ... | 1992 | 1525566 |
| dextrothyroxine in the treatment of generalized thyroid hormone resistance in a boy homozygous for a defect in the t3 receptor. | the dextroisomer of thyroxine (d-t4) has been shown to have suppressive effects on pituitary tsh secretion in euthyroid individuals and patients with mild thyroid hormone resistance. we treated a 3-year-old boy with d-t4 who was homozygous for a t3 receptor defect, resulting in a complex clinical picture of tissue-specific hyperthyroidism and hypothyroidism. there was no evidence of significant alteration in thyroid physiology, including serum concentrations of basal and trh stimulated tsh or ec ... | 1992 | 1525565 |
| prospective study on thyroid function anomalies in severely ill patients. | patients with severe non-thyroidal illness (nti) often evidence concomitant anomalies in thyroid function (tf). in order to shed light on the implications of these anomalies and/or changes and disease course, we monitored tf changes in a selected cohort of 45 patients with serious nti (21 with liver cirrhosis, 15 with renal failure and 9 with malignancy) from april 1985 to october 1989. tf test results on admission were as follows: all patients had normal thyroid stimulating hormone (tsh) levels ... | 1992 | 1524944 |
| [a chronic alcoholic patient with the development of frank diabetes after heavy drinking and perfect improvement following abstinence from alcohol]. | we experienced a chronic alcoholic patient in whom a large intake of alcohol led to the development of frank clinical diabetes, and glucose intolerance and insulin deficiency improved perfectly following abstinence from alcohol. the patient was a 31-year-old male with no diabetes among his relatives. he was a heavy drinker since 12 years, and especially had a large intake of alcohol from dec. 25 '84 to jan. 3 '85. from the end of jan. 1985 he complained of thirst, polydipsia, polyuria and body w ... | 1992 | 1524526 |
| [neuroendocrine disorders in brain-dead donors at the time of multiorgan harvesting]. | changes in the level of antidiuretic hormone (adh), adrenocorticotropic hormone (acth), somatotropic hormone (sth), follicle-stimulating hormone (fsh), luteinizing hormone (lh), thyroid-stimulating hormone (tsh), prolactin (pl), thyroxin (t4), triiodothyronine (t3) and thyroxine-binding globulin (tbg) have been assessed before and during multiorgan excision in 22 donors with brain death. a progressing decrease in adh blood supply and changes in acth, sth, fsh and pl content have been recorded. n ... | 1992 | 1524255 |
| effects of thyroxine on the photoperiodic control of energy balance and reproductive status in siberian hamsters. | siberian hamsters (phodopus sungorus sungorus) exhibit a variety of seasonal responses when exposed to short days (sd), including decreases in body weight and fat, gonadal regression, and changes in several nonsteroid serum hormone concentrations. one such sd-induced hormonal change is a modest decrease in serum thyroxine (t4) concentrations. in an attempt to determine any underlying hormonal influences for the sd-induced decreases in body weight and fat, we investigated the possible role of t4 ... | 1992 | 1523252 |
| lymphocyte subsets in children younger than 2 years old: normal values in a population at risk for human immunodeficiency virus infection and diagnostic and prognostic application to infected children. | data were collected prospectively from 116 children younger than 2 years old who were seen at the duke pediatric aids clinical trials unit for known human immunodeficiency virus seropositivity. forty-six (40%) of these children were human immunodeficiency virus-infected and 70 were not infected. using 3-month blocks, 10th, 50th and 90th percentiles were calculated for the cd4+ and cd8+ cell counts, percentage of lymphocytes positive for cd4 and cd8 and t4:t8 ratios. results from the infected and ... | 1992 | 1523075 |
| thyroid in intermediary metabolism of the migratory redheaded bunting, emberiza bruniceps (brandt). | effect of thyroidectomy and replacement therapy with l-t4, on liver and plasma biochemical constituents of e. bruniceps, was studied during january (recovery phase). thyroidectomy elevated significantly the levels of plasma glucose, protein, cholesterol, diglyceride, hepatic cholesterol and depressed significantly hepatic free fatty acid without affecting liver and body weights. treatment of thyroidectomized birds with l-t4 restored liver and plasma constituents, but had significantly depressed ... | 1992 | 1521869 |
| [thyroid function tests in healthy and ill elderly]. | thyroid function in the elderly has been a matter of discussion. the universe of the present study includes males and females 36 hospitalized with an average age of 72.97 +/- 8.70 years (group i) and 36 ambulatory asymptomatic elderly with 69.81 +/- 8.55 years of age (group ii). serum levels of t3, t4, t4l and tsh were measured in both groups. mean values of t3 were significantly lower in the hospitalized patients than in the control group. the difference persisted on both, males and females, an ... | 1992 | 1521745 |
| [triiodothyronine is needed for the acclimatization of brown trout (salmo trutta) or rainbow trout (oncorhynchus mykiss) to seawater]. | brown and rainbow trout, held in freshwater at 13 +/- 1 degrees, were injected, every 3 days, with iopanoic acid (iop: 5 mg/100 g body wt), an inhibitor of deiodination of thyroxine (t4) to triiodothyronine (t3). one group of iop-treated rainbow trout was immersed in t3 (20 micrograms/l water). in iop trout, plasma t3 fell to very low levels by day 7, while changes in t4 levels were less marked. in iop + t3 trout plasma t3 increased fivefold, plasma t4 being unchanged. no mortality occurred and ... | 1992 | 1521165 |
| structural and functional microheterogeneity of rat thyroxine-binding globulin during ontogenesis. | thyroxine-binding globulin (tbg), the major carrier of thyroid hormones in human and murine sera, is in the rat a developmentally regulated protein, showing a large surge during post-natal growth followed by virtual disappearance in adults. here we study as a function of age, from the 19-day embryo to 60 days after birth, the structural and binding characteristics of rat tbg microheterogeneity. serum obtained throughout development, when pre-incubated with 125i-thyroxine (t4), was shown by isoel ... | 1992 | 1520259 |
| thyroid hormones and depressive illness: implications for clinical and basic research. | it has been well-known for at least 100 years that both hypo- and hyperthyroidism may cause almost any psychiatric symptom, depending on the severity of the illness. no thyroid disorder, however, induces symptoms that are specific for a psychiatric disorder. laboratory tests show depressed patients to be euthyroid. any abnormalities that have been found, such as slightly elevated t4 levels or decreased t3 or tsh concentrations, have frequently failed to be replicated and do not fit any endocrino ... | 1992 | 1519467 |
| antidepressants and thyroid hormone levels. | we assessed the effect of treatment with the tricyclic antidepressant, desipramine, on peripheral thyroid hormone levels in 28 severely depressed patients. only those whose depression responded showed a decrease in their thyroxine levels without alteration of other thyroid function tests. in a second study involving 38 depressed patients, we observed an increased response to antidepressant treatment with the addition of triiodothyronine but not equivalent doses of thyroxine (t4). the finding is ... | 1992 | 1519466 |
| effects of selenium and iodine deficiency on iodothyronine deiodinases in brain, thyroid and peripheral tissue. | long term nutritional selenium (se) deficiency had only marginal effects on the thyroid t4 and t3 content and on the activity of the selenoenzyme type i deiodinase (5'd-i) in the thyroid gland. these findings reveal a remarkable resistance of the thyroid to se-deficiency which may substantially contribute to the observed maintenance of t4 and t3 levels in circulating blood. in contrast to its maintained thyroidal activity, 5'd-i in peripheral tissues like liver and kidney was strongly decreased ... | 1992 | 1519461 |
| integration of thyroid hormones with hypothalamic factors on pituitary tsh secretion. | a study employing a newly developed fourth generation immunometric serum tsh assay (assay limit 0.001 mu/l was performed to determine the temporal pattern of inhibition of serum tsh in response to a maximal suppressive dose of thyroid hormone (t3, t4 and triac) as compared to the pattern produced by dopamine (da) and dexamethasone (dex). mean onset of inhibition was 24, 48 and 68 minutes for thyroid hormone, da and dex, respectively. the inhibitory pattern was uniform and reproducible for the sa ... | 1992 | 1519458 |
| the possible etiological role of psychological disturbances in graves' disease. | in the discussion of possible factors in the etiology of graves' disease, stress has always played a major role. we investigated the possible influence of present depression (depressivity scale ds) and anxiety (state trait angstinventar stai x1) on peripheral lymphocyte subpopulations in 10 patients with graves' disease. the tests were done in hyperthyroidism and after 2-4 months in stable euthyroidism. parallel to the psychometric testing, peripheral lymphocyte subpopulations were investigated. ... | 1992 | 1519457 |
| regulation of t3 production in the brain. | intracerebral thyroid hormone metabolism is responsible for maintaining intracellular t3 levels within narrow limits. a coordinated regulation of brain t4 to t3 conversion and t3 degradation allows the brain to respond to changes in the availability of circulating t4 and thereby isolates the brain from environmentally influenced changes in thyroid hormone status. t4 to t3 conversion is regulated by dynamic increases or decreases in the cellular content of the enzyme that catalyzes this reaction ... | 1992 | 1519453 |
| maternal hypothyroxinemia and brain development: i. a hypothetical control system governing fetal exposure to maternal thyroid hormones. | maternal hypothyroxinemia consequent on endemic iodine deficiency is associated with an increased incidence of neurological disorders in the offspring. such correlations were originally postulated as reflecting direct effects of elemental iodine on fetal brain development during early pregnancy, it being generally believed that maternal thyroid hormones do not cross the placenta in significant amount in consequence of the presence of elevated concentrations of tbg in maternal blood. however tbg ... | 1992 | 1519451 |
| the role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain. | cerebrospinal fluid (csf) transthyretin (ttr), the main csf thyroxine (t4) carrier protein in the rat and the human is synthesized in the choroid plexus (cp). after injection of 125i-t4 in the rat, radioactive t4 accumulates first in the cp, then in the csf and later in the brain. we have shown that competitive inhibition of t4-ttr binding sites in the cp and csf by a flavonoid results in a decrease in the radioactivity present in the brain after i.v. injection of 125i-t4, suggesting that t4 tra ... | 1992 | 1519447 |
| the movement of thyroid hormones in the central nervous system. | thyroid hormones in the central nervous system (cns) present a number of complexities which include a marked difference in hormone effects on the developing brain compared to the mature brain, extensive regional heterogeneity within the brain, and alternate ways by which the hormones gain entry to the cns and its cells. furthermore, most of the t3 found within brain cells is derived from the t4 that they have accumulated. this brief review concerns the movement of the thyroid hormones as they le ... | 1992 | 1519446 |
| characteristics of type iii iodothyronine deiodinase. | type iii iodothyronine deiodinase (id-iii) catalyzes the inner ring deiodination of t4 to rt3 and of t3 to 3,3'-t2, representing an important pathway for the inactivation of thyroid hormone. high activities of this "oncofetal" enzyme are found in rat brain, skin and fetal intestine, rat and human placenta, chick embryo liver, monkey hepatocarcinoma cells, human colon carcinoma cells, and tadpole liver. id-iii shows substrate preference for t3 over t4; km values are approximately 10-fold lower fo ... | 1992 | 1519445 |
| homeostasis of brain t3 in rat fetuses and their mothers: effects of thyroid status and iodine deficiency. | faced with large variations in iodine, t4 or t3 supply, the fetal brain is able to maintain t3 homeostasis to a greater degree than apparent from changes in plasma and other tissues, such as the liver. changes in the activity of 5'd-ii play an important role in this homeostasis, although this does not exclude other regulatory mechanism(s), such as changes in type iii (5d) activity, in uptake of the iodothyronines by the brain, or in cerebral iodothyronine turnover rates. t3 generated locally fro ... | 1992 | 1519443 |
| effects of thyroxine, triiodothyronine and reverse triiodothyronine on the neonatal hypothyroid rat cerebellum. | in order to develop a model of thyroid hormone action, we studied the effect of small doses of t3 and t4 on the development of the hypothyroid neonatal cerebellum of rat pubs. using granulosa cell death at postnatal d15 (picnotic index) as a criterion of hypothyroidism, it was found that a single injection of 50 ng t3/10g bw or 180 ng t4/10 g bw would reduce the picnotic index to levels found in euthyroid rat cerebelli. we further tested if rt3, known to be an excellent blocker of deiodinase typ ... | 1992 | 1519442 |
| thyroid hormones influence perceptual processing in a visual search paradigm. | the mechanisms that mediate the effects of thyroid hormones on higher cognitive processes are not well understood. in the present experiments, event-related potentials (erps) and behavioral measurements were recorded in a visual search paradigm where a target item had to be detected in a number of distractor items. 10 healthy subjects were given a daily dose 300 micrograms thyroxine (t4) p.o. and recordings were made before and after 3 weeks of treatment. all subjects developed hyperthyroidism w ... | 1992 | 1519441 |
| effects of thyroid hormones on mitochondrial oxygen consumption in brown adipose tissue and heart from cold-exposed hypothyroid rats. | the present work measured brown adipose tissue and heart mitochondrial oxygen consumption in hypothyroid rats treated with replacement doses of t3, t4 or t4 plus iopanoic acid and kept at 4 degrees c for 24 h. heart oxygen consumption in normal, untreated hypothyroid and t4-treated hypothyroid rats was unaffected by cold exposure. in rats treated with t4 plus iopanoic acid, rates of oxygen consumption were normal in those maintained at 4 degrees c as well as in those kept at room temperature, de ... | 1992 | 1519427 |
| alterations in circadian rhythm of serum thyrotropin in critically ill patients. | to evaluate the 24-h pattern of serum thyrotropin (tsh) in critically ill patients, we measured serum concentrations of tsh in blood samples collected every 2 h for 24 h from nine patients (six with malignancy, two with liver cirrhosis, one with chronic renal failure), who had subnormal levels of both triiodothyronine (t3) and thyroxine (t4), in the absence of history, symptoms or signs of thyroid disease. analysis of the data, performed using a second-order inferential statistical methodology f ... | 1992 | 1519418 |
| follow-up data of our pilot study on concomitant hyperfractionated radiotherapy and cisplatinum (cddp) in patients with advanced cancer of the head and neck. | since 1988, 52 patients with stage iii/iv squamous cell cancer of the head and neck have been treated by concomitant irradiation with 2 x 1.2 gy/d on five days per week up to a total dose between 72 and 76.8 gy without split and 5 x 20 mg/m2 cisplatinum (cddp) as short infusion finished approximately 30 min before the second session on five days of the first and the fifth week of radiotherapy. radiotherapy has been suspended after 30 and 50 gy in three patients for insufficient response. in all ... | 1992 | 1519161 |
| effects of inorganic iodide, epidermal growth factor and phorbol ester on hormone synthesis by porcine thyroid follicles cultured in suspension. | porcine thyroid follicles cultured in suspension for 96 h synthesized and secreted thyroid hormones in the presence of thyrotropin (tsh). the secretion of newly synthesized hormones was assessed by determining the contents of thyroxine (t4) and triiodothyronine (t3) in the media and by paperchromatographic analysis of 125i-labelled hormones in the media where the follicles were cultured in the presence and absence of inhibitors of hormone synthesis. the hormone synthesis and secretion was modifi ... | 1992 | 1518372 |
| thyroid function in premature infants. | the present study was performed using the simultaneous assays of free t4 and tsh levels in dried blood spots of filter paper for mass-screening of inborn errors of metabolism in order to clarify the thyroid function of premature infants. the subjects were divided in three groups: a group infants less than 1500 g at birth (n = 34, 27.4 +/- 2.6 weeks of gestational age), b group infants from 1500 to 2500 g at birth (n = 104, 35.6 +/- 2.4 weeks) and c group infants over 2500 g at birth (n = 490, 39 ... | 1992 | 1518270 |
| predictors of hiv-1 disease progression in early- and late-stage patients: the u.s. army natural history cohort. military medical consortium for applied retrovirology. | hiv-infected individuals in both early and late stages of hiv disease were evaluated over 2 years to assess temporal trends and determinants of disease progression. the walter reed (wr) staging system was used to categorize patients into an early-stage cohort (wr stages 1 and 2, n = 1183) and a late-stage cohort (wr stage 5, n = 260) based on the initial clinical evaluation. progression was defined as the occurrence of stage 5 disease or beyond for the early cohort and stage 6 disease or beyond ... | 1992 | 1517964 |
| n-methyl-d-aspartate does not prevent effects of melatonin on the reproductive and thyroid axes of male syrian hamsters. | the reproductive and thyroid status of male syrian hamsters maintained on long days (14 h light, 10 h darkness) were assessed after 10 weeks of daily injections of pharmacological doses of melatonin (25 micrograms s.c.) and/or n-methyl-dl-aspartic acid (nmda, 0.025-6 mg i.p.), a compound with receptor sites in the central nervous system which are known to affect reproduction. melatonin given during the late light phase decreased reproductive organ weights and levels of serum and pituitary prolac ... | 1992 | 1517708 |
| effect of administration of growth hormone on plasma and intracellular levels of thyroxine and tri-iodothyronine in thyroidectomized thyroxine-treated rats. | we have studied the effects of the administration of gh on plasma levels and peripheral production of tri-iodothyronine (t3) from thyroxine (t4) in thyroidectomized male wistar rats given a continuous i.v. infusion of t4 (1 microgram/100 g body weight per day) and gh (120 micrograms per day) for 3 weeks. tracer doses of 131i-labelled t3 and 125i-labelled t4 were added to the infusion. at isotopic equilibrium (10 days after the addition of 125i-labelled t4) the rats were bled and perfused. the pl ... | 1992 | 1517706 |
| effect of fenfluramine on serum t3, t4 and tsh levels in obesity. | a prospective, randomised case-control trial of an anorectic drug, fenfluramine was conducted on 30 patients of simple obesity. the study revealed that the drug was well tolerated, non-toxic and effective in reducing the body weight and normalising the thyroid profile. reduction in body weight, rise in serum thyroxine (t4) and fall in serum triiodothyronine (t3) was highly significant (p less than 0.01) in drug treated group as compared to controls (p less than 0.05) after 12 weeks of therapy. t ... | 1992 | 1517614 |
| organ-specific effects of tiratricol: a thyroid hormone analog with hepatic, not pituitary, superagonist effects. | tiratricol has been used to suppress pituitary tsh secretion, with reported attenuation of extrapituitary thyromimetic effects. a randomized, double-blind trial was performed to define precisely the tissue-specific thyromimetic actions of tiratricol. ten athyreotic patients, treated for thyroid carcinoma, were randomly assigned to receive l-t4 sodium 0.7 micrograms/kg daily and either tiratricol 10 micrograms/kg or placebo twice daily. the daily dose of l-t4 was increased by 25-50 micrograms inc ... | 1992 | 1517383 |
| does graves' disease or thyrotoxicosis affect the prognosis of thyroid cancer. | twenty-one patients who underwent surgical treatment for thyrotoxicosis and who were found at operation to have thyroid cancer are presented. sixteen had graves' disease and 5 had toxic nodular goiter. the group with graves' is compared with 110 euthyroid patients with thyroid cancer who underwent their initial surgery in the same time period and who were of the same age (+/- 1 yr) and sex as the patients with graves' disease. none of the thyrotoxic patients died during follow-up of 2-24 yr or d ... | 1992 | 1517381 |
| maternal and neonatal thyroid function at birth in an area of marginally low iodine intake. | thyroid function was evaluated in cord serum of healthy full-term newborns and compared to that of mothers immediately after parturition. the study was carried out in an area without overt iodine deficiency, but with a marginal iodine supply (less than 100 micrograms/day in 80% of women). the aim of the study was to delineate the interrelationships between the thyroid statuses of mother and child at birth. maternal thyroid function was characterized at delivery by relative hypothyroxinemia; incr ... | 1992 | 1517370 |
| effects of iodine on thyroid status of fetus versus mother in treatment of graves' disease complicated by pregnancy. | to investigate the effect of maternal iodine therapy for graves' disease on fetal thyroid, we examined serum free t4 (ft4) and tsh levels in the fetus vs. those in the mother. patients who were severely thyrotoxic were not included. cord and maternal sera were tested at delivery in 35 patients with graves' disease treated with iodine alone during pregnancy (6-40 mg daily). at the initiation of therapy, the mothers were at 11-37 weeks gestation, and ft4 levels ranged from 28.3-65.8 pmol/l. at del ... | 1992 | 1517362 |
| 3,3',5'-triiodothyronine inhibits collagen-induced human platelet aggregation. | to clarify further the activity of rt3, we examined the effect of rt3 on collagen-induced platelet activation as reflected by aggregation, serotonin release, and protein phosphorylation. rt3, t4, t3, and triiodothyroacetic acid inhibited collagen-induced platelet aggregation and serotonin release from platelets in a dose-dependent manner. however, thyronine did not inhibit collagen-induced platelet aggregation. the concentration at which rt3 inhibited by 50% collagen-induced platelet aggregation ... | 1992 | 1517361 |
| critical functional role of the cooh-terminal ends of longitudinal hydrophobic strips in alpha-helices of t4 lysozyme. | the sensitivity of bacteriophage t4 lysozyme function to amino acid substitutions at defined positions in and around the longitudinal, hydrophobic strips of 9 alpha-helices was assessed after systematic replacement of each residue in the protein with a series of 13 amino acids. the hydrophobic strips were defined by identifying the longitudinal sectors in the helices with the highest mean residue hydrophobicities. sensitivity to mutation (the percentage of replacements leading to loss of functio ... | 1992 | 1517218 |
| radioimmunoassay monitoring of thyroid hormone concentrations in dogs on thyroid replacement therapy: 2,674 cases (1985-1987). | serum iodothyronine concentrations from 4,064 samples submitted for monitoring of thyroid replacement therapy were evaluated in a retrospective study. after exclusion of samples because of the presence of 3,5,3' triiodothyronine (t3) autoantibodies, insufficient numbers of dogs on some commercial preparations or medication with corticosteroids or synthetic t3 preparations, data from 2,674 dogs remained. data were analyzed by using information on dose, time after dosing, commercial product, and o ... | 1992 | 1517142 |
| chronic thyroiditis: thyroid function and histologic correlations in 601 cases. | six hundred one patients with histologically proven "chronic thyroiditis" were assessed for the correlation of thyroid function to histologic findings. the histology of chronic thyroiditis was classified into four groups (oxyphilic, mixed, focal, and hyperplastic), and the thyroid function of patients was divided into hyperthyroid, euthyroid, latent hypothyroid, and overt hypothyroid, based on the laboratory data of serum triiodothyronine (t3), thyroxine (t4), and thyrotropin (tsh) levels, as we ... | 1992 | 1516932 |
| 3,5-t2 stimulates oxygen consumption, but not glucose uptake in human mononuclear blood cells. | l-thyroxine (t4), l-triiodothyronine (t3) and 3,5-di-iodothyronine (t2) rapidly (within 30 min) stimulated oxygen consumption in human mononuclear blood cells, whereas the d isomers of t4 and t3 and triac had no stimulatory effect. oxygen consumption was stimulated by the same magnitude by equimolar concentrations (5-500 nmol/l) of l-t4, l-t3 and 3,5-t2 reaching a plateau at 100 nmol/l of 0.025 umol/mg dna x h. the stimulatory effects of t4 and t3, but not of t2 were inhibited by ptu. glucose up ... | 1992 | 1516887 |
| suppression of thyroid cell growth by serum igg in graves' disease. | to determine whether serum immunoglobulin in addition to epidermal growth factor (egf) augment growth in human thyroid cells, effects of these factors on thyrocytes were tested using igg derived from 34 patients with graves' disease and 12 normal subjects. the cell growth was estimated by [3h]-thymidine uptake, cell cycle determined by facs analysis and the expression of c-fos mrna in monolayer thyrocytes enzymatically prepared from graves' thyroid. the addition of igg taken from patients with g ... | 1992 | 1516886 |
| genetic recombination in bacteriophage t4: single-burst analysis of cosegregants and evidence in favor of a splice/patch coupling model. | to reveal the structure of penultimate dna intermediates in t4 bacteriophage recombination, resolution of which produces free recombinant molecules, a single-burst analysis of the recombinant progeny was made in multifactor crosses, enabling one to determine quantitatively the different recombinants generated by one or two exchanges within the same chromosome segment. it was found that double and single exchanges are highly correlated in t4 recombination. these results were interpreted as eviden ... | 1992 | 1516814 |
| [computed tomography: the tnm staging of laryngeal carcinoma]. | in 64 patients with malignant lesions of the larynx, ct and microlaryngoscopy (ml) were evaluated in terms of t-staging. histological information was present in all cases following operation. ct showed an accuracy of 90% in t-staging. ml showed an accuracy of only 71% of correct t-staging. ct is superior to ml particularly in distinguishing between stages t3 and t4 and t1 and t2. ct tends to overestimate tumour stage whereas ml tends to underestimate it. ct was also compared with palpation and s ... | 1992 | 1515626 |
| sequencing of the variant thyroxine-binding globulin (tbg)-san diego reveals two nucleotide substitutions. | thyroxine-binding globulin (tbg) is a liver glycoprotein that transports thyroid hormone in serum. in 1989, a variant tbg was reported with reduced binding affinity for thyroxine (t4) and triiodothyronine (t3) which results in low serum t4 and t3 levels. this variant, tbg-san diego (tbg-sd), also displays reduced heat stability but has a normal isoelectric focusing pattern. we now report the sequence of the entire coding region of tbg-san diego. it reveals two nucleotide substitutions: one locat ... | 1992 | 1515456 |
| effects of epidural bupivacaine or mepivacaine on somatosensory evoked potentials and skin resistance responses. | the main purpose of this study was to compare the depth of neural block in lumbar epidural analgesia using either 20 mg/ml mepivacaine or 5 mg/ml bupivacaine. | 1992 | 1515386 |
| the addition of epinephrine to subarachnoid administered hyperbaric bupivacaine with fentanyl for cesarean delivery: the effect on onset time. | this study examines the effect of epinephrine on the time to achieve a t4 sensory level when added to a hyperbaric bupivacaine-fentanyl mixture for spinal anesthesia. | 1992 | 1515385 |
| hemodynamic effects of continuous spinal anesthesia: a comparative study between low and high doses of bupivacaine. | arterial hypotension is a major side effect of spinal anesthesia. continuous spinal anesthesia may allow titration of the amount of local anesthetic to obtain a level that is appropriate for the surgical procedure. | 1992 | 1515383 |
| curative non-surgical combined treatment of squamous cell carcinoma of the oesophagus. | between april 1982 and june 1989, 65 patients (15 t1, 13 t2, 32 t3, 5 t4) with squamous cell carcinoma of the oesophagus were treated with a curative intent with multimodality combined treatment. a first course of 5-fluorouracil and cisplatin was given during work up, especially if ndyag laser therapy was used. irradiation was started 3-4 weeks after induction and two courses of concomitant chemotherapy were given during the radio therapy (aiming at 64 gy over 7 weeks). actuarial survival was 79 ... | 1992 | 1515254 |
| age-related changes in thyroid structure and function in sprague-dawley rats. | investigation of thyroid glands from 500 male and 500 female sprague-dawley rats, at time points of 8, 17, 30, 56, and 108 weeks of toxicity studies conducted at the huntingdon research centre between 1981 and 1984, revealed age-related structural and functional changes that have previously not been well documented. the number of ultimobranchial cysts decreased with age, while area(s) of c-cell hyperplasia appeared with age. beginning at 56 weeks, some of the thyroid follicles were hyperdistende ... | 1992 | 1514215 |
| [role of the liver in optimization of the thyroid status of rats in hypothyrosis caused by irradiation]. | experiments were made on 100 random bred rats of various age groups, controls and animals exposed to single external gamma-radiation at a dose of 1 gy on the 35th day of life. thyroxine and triiodothyronine concentrations were investigated in peripheral blood and separately in arterial blood, in thyroid, portal and hepatic venous blood. the activity of t4 conversion into t3 by 5'-deiodinating enzymes of the liver microsomal fractions and the activity of the liver mitochondrial enzymes--cytochrom ... | 1992 | 1513775 |
| p3 recordings in patients with bilateral temporal lobe lesions. | we recorded event-related potentials to an acoustic "oddball" paradigm from 19 scalp derivations in five patients (three women and two men; age range, 44 to 56) who had global amnesia following encephalitis. ct and mri showed severe bilateral lesions of anterior and midtemporal lobes. a p3 component, with a peak latency within the normal limits for age-matched controls, was recorded to "target" stimuli in four patients from all leads except fp1, fp2, f7, f8, t3, and t4. in the fifth patient, the ... | 1992 | 1513467 |
| thyroid ultrasonography related to clinical and laboratory findings in patients with silent thyroiditis. | we summarized the clinical course of 10 patients with silent thyroiditis and evaluated the clinical usefulness of ultrasonography, in combination with clinical and laboratory findings, for the differentiation from graves' disease. serum t3 and t4 were increased in all cases, and the ratio of t3/t4 (ng/micrograms) was 17.8 +/- 3.6 (sd). but in 3 of 10 patients the ratio was greater that 20. tsh receptor antibody (trab) and thyroid stimulating antibody (tsab) were negative in all cases. the estima ... | 1992 | 1512420 |
| hormonal regulation of cholesterol 7 alpha-hydroxylase mrna levels and transcriptional activity in primary rat hepatocyte cultures. | in primary cultures of adult rat hepatocytes the level of cholesterol 7 alpha-hydroxylase steady-state mrna markedly decreased by 72 h. however, the addition of l-thyroxine (t4) and dexamethasone synergistically returned cholesterol 7 alpha-hydroxylase steady-state mrna levels near to that of cholestyramine-fed animals. the maximal responses to t4 and dexamethasone in serum-free medium were at 1.0 and 0.1 microm, respectively. the addition of t4 in combination with dexamethasone resulted in an 1 ... | 1992 | 1512229 |
| tandem cloning of bacteriophage t4 nrda and nrdb genes and overproduction of ribonucleoside diphosphate reductase (alpha 2 beta 2) and a mutationally altered form (alpha 2 beta 2(93)). | to investigate the role of ribonucleoside diphosphate reductase in the deoxyribonucleoside triphosphate synthetase multienzyme complex induced by bacteriophage t4 infection and to study the expression of the t4 nrda and nrdb genes, we have constructed separate plasmid expression strains overproducing their respective alpha 2 and beta 2 protein products. because complementation of the two proteins to form an active alpha 2 beta 2 enzyme presented complications, nrda and nrdb, each with its own ta ... | 1992 | 1512207 |
| in vitro characterization of repair synthesis initiated by t4 endonuclease v on a synthetic dna substrate. | the size of the repair patch produced by e. coli dna polymerase (pol i) following the removal of a pyrimidine dimer from dna in response to the nicking activity of t4 endonuclease (t4 endo v) was determined. a 48-bp dna containing a pyrimidine dimer at a defined location was labelled in the damaged strand and incubated with t4 endo v and e. coli endonuclease iv. subsequently, dna synthesis by dna pol i was carried out in the presence of four dntps, atp and dna ligase. analysis of the reaction pr ... | 1992 | 1512008 |
| local staging and assessment of resectability in carcinoma of the esophagus, stomach, and duodenum by endoscopic ultrasonography. | eighty-eight patients with carcinoma of the esophagus (n = 44), stomach (n = 41), and duodenum (n = 3) who underwent surgery were pre-operatively examined by endoscopic ultrasonography (eus). the ability of eus to accurately predict the t stage and the n stage was 82% and 70% for esophageal carcinoma, 71% and 75% for gastric cancer, and 100% and 66% for duodenal malignancy. in esophageal carcinoma, the accuracy of t staging was only slightly lower in cases with non-traversable tumor stenoses (77 ... | 1992 | 1511822 |
| protein folding: assignment of the energetic changes of reversible chemical modifications to the folded or unfolded states. | reversible chemical modifications of a series of single cysteine-containing variants of t4 lysozyme combined with thermal denaturation studies have been used to study the effects of these modifications on the stability of the protein. this allows dissection of the energetic effects of the modification on both the native and denatured states of this protein. at some sites modifications with various chemical reagents have essentially no effect on the stability of the protein, while at others, subs ... | 1992 | 1510962 |
| phase i-ii pilot study on the efficacy and tolerability of neoadjuvant chemotherapy (rescue m-vec) and preoperative radiation therapy for infiltrating bladder cancer: results of an 18-month follow-up. | in spite of the improvement of surgical techniques used alone or in combination with preoperative radiation therapy, more than 50% of the patients with infiltrating transitional cell carcinoma (tcc) of the bladder die of distant metastases. systemic antiblastic polychemotherapy has been reported to achieve a complete remission rate of approximately 30% in patients with infiltrating bladder tcc, although there are still doubts relative to the duration of such complete remissions. this study inves ... | 1992 | 1510485 |
| thyroid function during l-asparaginase therapy in children with acute lymphoblastic leukemia: difference between induction and late intensification. | parameters of thyroid function were measured in nine children during induction therapy for acute lymphoblastic leukemia (all). seven patients were reevaluated during the late intensification phase. vincristine, anthracycline drugs (daunorubicin and adriamycin), corticosteroids, and l-asparaginase were used in the two phases of therapy. during induction, l-asparaginase (5,000 u/m2) was given daily on days 1-21. during late intensification, the drug was given on days 1, 4, 8, and 11 (10,000 u/m2). ... | 1992 | 1510186 |
| cedia--homogeneous immunoassays for the 1990s and beyond. | new homogeneous enzyme immunoassays have been developed for cortisol, digoxin, digitoxin, theophylline, phenytoin, and phenobarbital using the cloned enzyme donor immunoassay technology. as applied to boehringer mannheim/hitachi analysis systems these methods provide rapid, accurate and precise quantification of analytes, with minimal interferences from endogenous serum constituents and low cross-reactivities to structurally-related hormonal precursors, drug metabolites and natural compounds. ad ... | 1992 | 1509755 |
| the influence of thyroxine on the differentiation of adipose tissue and skin during fetal development. | preobese fetuses have elevated thyroid hormone levels and depressed growth hormone levels relative to lean fetuses. therefore, we are studying various experimental fetal pig models to explore the relationship between endocrine status and onset of obesity. in the present study, intact and hypophysectomized (d 70) fetuses were implanted with thyroxine (t4) pellets on d 70 of gestation, and blood, adipose tissue, and skin samples were obtained upon removal of d 90 of gestation. body weights were si ... | 1992 | 1508611 |
| beneficial effects of training on developing dystrophic muscle. | the objective of this study was to determine whether increased contractile activity is beneficial or detrimental to developing dystrophic muscle. hamsters (20-days-old) were gradually introduced to running at a speed of 14 m/min at 10% grade for 2 (t2) or 4 (t4) h/d for 4 weeks, 5 d/wk. histological and fiber type properties were determined in the soleus (sol), plantaris (pl), and extensor digitorum longus and contractile properties in sol and pl from 5 animals/group, including 5 controls. exper ... | 1992 | 1508231 |
| a case of rheumatoid arthritis associated with silent thyroiditis. | a 41-year-old female with rheumatoid arthritis had nontender enlarged thyroid gland. thyroid function tests revealed increased concentrations of serum free t3 (ft3, 10.8 pmol/l) and free t4 (ft4, 31.1 pmol/l) with suppressed concentration of thyrotropin (tsh, lower than 0.1 mu/l) and low 24-hour thyroidal radioactive iodine uptake (1.6%). serum thyrotropin receptor antibody (trab) was negative (0%) and she had positive anti-thyroglobulin and anti-microsomal antibodies. a diagnosis of silent thyr ... | 1992 | 1506621 |
| thyroid and adrenal function in the ring dove (streptopelia risoria) during food deprivation and a breeding cycle. | the concentration of plasma triiodothyronine (t3), thyroxine (t4), corticosterone, and glucose as well as body weight and food intake were measured in pairs of ring doves throughout a breeding cycle and during food deprivation. during courtship and incubation the levels of plasma t4 were significantly higher in males than in females. a transitory decrease in food intake in both sexes was measured at the onset of incubation but was not associated with a change in body weight or in levels of plasm ... | 1992 | 1505723 |
| the effect of hypothyroidism on sertoli cell proliferation and differentiation and hormone levels during testicular development in the rat. | in this study we show that 6-propyl-2-thiouracil (ptu) treatment of wistar rats from birth up to day 26 p.p. retards the morphological differentiation of sertoli cells, and prolongs the proliferation of these cells up to day 30. sertoli cell numbers per testis, determined at day 36, were increased by 84% compared to controls. ptu treatment increased serum thyroid-stimulating hormone (tsh) levels and reduced serum levels of thyroxine (t4) from 5 days onwards, indicative of severe hypothyroidism. ... | 1992 | 1505485 |
| [endemic goiter in the la kara region (togo). analysis of etiologic factors]. | among 6,035 people living in 3 villages from the area of la kara (togo), 984 randomized subjects were investigated to evaluate goiter prevalence and related etiologic factors. creatinine and thiocyanates (scn-) were measured in urine, thyroid hormones and tsh in plasma. iodine was evaluated in urine, water, salt, soil, millet and sorgho. the amount of cassava was evaluated in food. mean goiter prevalence was 32%, reaching to 45.9% in one village; urinary iodine remained in a low range (27.2 +/- ... | 1992 | 1504874 |
| flexibility in crystalline insulins. | comparisons of atomic models for chemically identical protein molecules solved in differing crystal environments provide information on flexibility in the protein structure. the structures of five t4 lysozyme proteins in differing crystal environments showed large relative displacements of the two domains with conserved backbone conformations that are connected by a flexible hinge (h. r. faber and b. w. matthews. 1990. nature (lond.). 348:263-266). in contrast, my comparison of the positions of ... | 1992 | 1504252 |
| [previous dissociative psychiatric disorder and status epilepticus in a case of acute hiv infection]. | we described an 18 old homosexual man who after 5 days developed a neurologic picture associated with human immunodeficiency viruses (hiv) seroconversion. the patient had developed a dissociative psychiatric disorder 6 months before, and after resolution of the acute neurologic disease a mild neuro-psychiatric disorder remained. after mononucleosis-like syndrome of three weeks, the patient developed a meningo-encephalitic process 48 h post admission. he evolved with tonic seizures and twilight s ... | 1992 | 1504207 |
| the role of hereditary factors in phenotypic variability of hormone levels in the population genetically adapted to circumpolar environment. | the variability of the plasma cortisol, t3, t4, tsh and estradiol levels were studied in the north khanty population genetically adapted to the extreme conditions of the north. the relationships between genetic markers and hormone concentrations were also studied. negative linear correlations of t3 and t4 levels with age were obtained. cortisol, estradiol and t3 levels showed nonlinear age dependency. t4 concentrations were significantly lower in august than in february and november. the highest ... | 1992 | 1503581 |
| [accidental spinal anesthesia in obstetrics. limits of epidural test-dose]. | two cases of accidental spinal anaesthesia occurring in obstetrical patients are reported and discussed. epidural anaesthesia had been asked for by the women, both being free from any significant medical history. a tuohy needle was inserted in the midline between l3 and l4 with the patient sitting. the extradural space was identified by the loss of resistance using saline. the test-dose (2 ml and 4 ml of 1% lignocaine respectively) was administered five minutes before changing the patient to the ... | 1992 | 1503317 |
| [effects of diazepam and incidence of hypoxemia during acute chloroquine poisoning]. | the effects of diazepam and the incidence of hypoxaemia on the course of acute chloroquine poisoning were studied prospectively in 21 patients. were excluded patients who had ingested more than one drug or who had major symptoms on admission (systolic blood pressure less than 80 mmhg; qrs greater than 0.12 s; cardiac dysrhythmias, respiratory disturbances). arterial blood gases were measured on admission (t0) and 15 min after 0.5 mg.kg-1 of diazepam had been given (t1). gastric lavage was carrie ... | 1992 | 1503289 |
| histologic changes in graves' thyroid gland after 131i therapy for hyperthyroidism. | the effect of 131i therapy was examined in 13 thyroid glands affected by graves' disease 3 to 29 years after irradiation for hyperthyroidism. all of the patients had clinically palpable thyroid nodules. two patients were in a latent hypothyroid, 6 in a euthyroid and 5 in a hyperthyroid state. the microscopic changes in the thyroids showed a pattern of multiple adenomatous nodules with cystic changes, marked oxyphilic cell changes with nuclear atypism and various degrees of chronic thyroiditis. i ... | 1992 | 1502902 |
| pyrimidine dimers in dna initiate systemic immunosuppression in uv-irradiated mice. | exposing the skin of mice to uv radiation interferes with the induction of delayed and contact hypersensitivity immune responses initiated at nonirradiated sites. the identity of the molecular target in the skin for these immunosuppressive effects of uv radiation remains controversial. to test the hypothesis that dna is the target for uv-induced systemic immunosuppression, we exposed c3h mice to uv radiation and then used liposomes to deliver a dimer-specific excision repair enzyme into the epid ... | 1992 | 1502162 |
| treatment of advanced bladder cancer by submucosal injection of methotrexate in the anorectal area. | in 1988, shafik et al. presented their first attempt to apply cytostatics in the treatment of pelvic malignancies. experimentally and clinically, they studied the anal route for administration of methotrexate, and their first results showed that higher concentration of drugs can be achieved in the bladder wall compared to that in serum. since december 1988, we have been engaged in experimental and clinical investigations of the possibilities this method might reveal. experiments with animals hav ... | 1992 | 1499627 |
| [the endocrine abnormalities of depressive patients]. | in the present study, the levels of the baseline cortisol, thyrotropin (tsh), triiodothyronine (t3), thyroxine (t4) and growth hormone (gh) were determined in 64 depressive patients, 17 patients with other depressive disorders and 19 normal controls. meanwhile, dexamethasone suppression test (dst) and insulin tolerance test (itt) were conducted. the baseline cortisol level at 23:00 in the depressive group (8.12 +/- 5.55 micrograms/dl) was significantly higher than that in the normal control grou ... | 1992 | 1499410 |
| prevalence of growth hormone deficiency of children in beijing. | 103,753 (male 51,994, female 51,759) primary and middle school students aged 6-15 years in two districts in beijing city were surveyed from october 1987 to april 1989. the heights of the students were measured. according to the height standard of northern cities in china, 202 students with heights below the 3rd percentile for age were requested for detailed history, physical examination, screening gh test bone age, t4, sgpt, chest x-ray, routine urine test and sex chromatin (in female). if gh le ... | 1992 | 1499371 |
| storage phosphor imaging technique for detection and quantitation of dna adducts measured by the 32p-postlabeling assay. | the 32p-postlabeling method has found wide application as a sensitive technique for detecting the presence of a broad range of bulky aromatic compounds covalently bound to dna. in this method, the modified dna is enzymatically degraded to 3'-mononucleotides and labeled with [32p]-phosphate at the 5'-position using [gamma-32p]atp and t4 polynucleotide kinase. the 32p-labeled dna digest is then chromatographed in two dimensions on polyethyleneimine - cellulose thin-layer plates. screen-enhanced au ... | 1992 | 1499099 |
| [study of the infiltrating lymphocyte subsets and transferrin receptor in gastric and colorectal carcinomas]. | infiltrating mononuclear cell (mnc) subsets and transferrin receptor (tfr) expression at the localized lesions were studied in 28 cases of gastric carcinoma and 36 cases of colorectal carcinoma by immunohistochemical technique by using a panel of monoclonal antibodies. the results showed that the percentage of t4+ cells in the infiltrating mncs decreased while that of t8+ cells increased relatively and the t4/t8 ratios declined along with the progression of the tumor. the tfr positive rates in g ... | 1992 | 1499078 |
| [pneumonia caused by non-opportunistic bacteria in patients infected with hiv. incidence and evaluation of a non-invasive approach]. | pneumonia due to pathogenic bacteria is common in hiv infected patients. however, a global overview has not been yet performed and also the effectiveness of a non-invasive approach has not been tested. | 1992 | 1498167 |
| effect of electrofusion pulse in either electrolyte or nonelectrolyte fusion medium on subsequent murine embryonic development. | this study was designed to determine what effect electropulse parameters would have on rate of fusion, lysis, and embryo viability when embryos were subjected to electrofusion treatment in nonelectrolyte or electrolyte pulse media. previous experiments have shown electrolyte medium (i.e., phosphate-buffered saline; pbs) to have a positive effect on electric pulse-induced murine oocyte activation. in addition, these results also indicated that pulse media containing 0.9 mm ca2+ induced a dramatic ... | 1992 | 1497875 |
| immune alterations in humans exposed to the termiticide technical chlordane. | lymphocyte phenotype frequencies and in vitro functional assays were studied in 27 individuals who had been exposed to technical chlordane in their homes or at their places of work. a control group consisted of 118 individuals who were similar to the exposed group with respect to age and sex distribution, and who had not knowingly experienced exposure to technical chlordane, was chosen for study. a significantly increased frequency of cortical thymocytes in the circulation (cd1) (p less than .00 ... | 1992 | 1497384 |
| [bone density in differentiated cancer of the thyroid gland treated by hormone-suppressive therapy. study based on 51 cases]. | the effect of l-thyroxine suppressive therapy (207.3 +/- 46.1 mcg/d) on lumbar spine bone density (bmd) was assessed in 51 patients thyroidectomized for carcinoma since 1 to 19 years (mean = 6 +/- 5.4 years); the bone densities of these patients were compared with those of 51 age sex weight-matched control subjects. trabecular bone density was evaluated by single energy quantitative tomography. the vertebral bmd was not significantly different between the patients receiving suppressive doses of ... | 1992 | 1496271 |
| [profile of thyroid hormones in aging: evaluation of a hospitalized elderly population]. | the aim of the study is to evaluate thyroid serum levels in a geriatric community to confirm the presence of a low t3 syndrome during normal ageing. the authors consider 413 subjects (125 male and 288 female) admitted to our geriatric division. the group affected by thyroid and extrathyroid disease (such us malnutrition, diabetes mellitus, renal failure, etc.) was withdrawn. in the selected patients (271) was operated a statistical evaluation to correlate the hormonal parameters (t3, t4, tsh, ft ... | 1992 | 1495452 |
| [effect of treatment with biosynthetic gh on thyroid function in patients with an isolated deficiency of gh]. | the use of gh treatment in subjects with a gh deficiency has led to contrasting results concerning its impact to develop thyroid hyperfunction, whereas many others have underlined the possible onset of hypothyroidism. a number of studies have been carried out over short periods in subjects with multiple tropin deficiencies, in healthy adults or adults with gh deficiencies, in healthy adults or adults with gh deficiencies. the aim of the present study was to assess the effect of prolonged treatme ... | 1992 | 1495450 |
| changes in plasma free thyroid hormones during cardiopulmonary bypass do not indicate triiodothyronine substitution. | concentrations of free and bound thyroid hormone in plasma during cardiopulmonary bypass were determined in 10 patients. ages ranged from 50 to 76 years (median 61 years). apart from thyroxine and triiodothyronine, a number of other variables that might contribute to an altered thyroid state or binding of thyroxine and triiodothyronine to plasma proteins were measured (thyroid stimulating hormone, reverse triiodothyronine, albumin, nonesterified fatty acids, and cortisol). at the end of the obse ... | 1992 | 1495289 |
| the differing predictive values of oestrogen receptor assays for large breast cancers. | thirty elderly patients with t3 or t4 breast cancer underwent a wedge biopsy for radioligand-binding assay (rla) of oestrogen receptor (er) activity. a second, separate group of 21 elderly patients with t3 and t4 breast cancers underwent fine needle aspiration biopsy (fna) for immunocytochemical assay of er (er-ica). all the women received tamoxifen as primary treatment and response was assessed by uicc criteria. tumour er concentration by rla was correlated with both response (spearman's r = + ... | 1992 | 1494511 |
| [dielectric analysis of the rat thyroid gland by modeling the follicle as a key structure]. | to correlate the dielectric behavior of the thyroid gland with its follicle structure, i examined the admittance properties of isolated rat thyroid hemilobes over the frequency range from 100 hz up to 500 mhz. rats were divided into three groups: control, thyroxine (t4) administered, and goitrogen (propylthiouracil, ptu) administered. in control glands, observed dielectric dispersions with a permittivity increment (delta epsilon) of 60,000 were of the beta-type having two separate characteristic ... | 1992 | 1494109 |
| [median-term (4 months) treatment with glibenclamide + metformin substituting for glibenclamide + fenformin lowers the lacticemia levels in type-2 diabetics (niddm)]. | 60 niddm patients, mean age (68 +/- 3 years), bmi (25 +/- 5.1 kg/m2), fasting blood glucose (fg) (170 +/- 10 mg/dl), mean daily blood glucose (mdbg) (180 +/- 10 mg/dl), daily glycosuria (glu) (15.6 +/- 9 g/24 hours), hba1c (7.9 +/- 0.6%), basal (1.2 +/- 0.2 ng/ml) and stimulated (3.89 +/- 1.3 mg/ml) c peptide (cp) treated by ass (7.5 +/- 75 mg), after a strict 4 months follow-up period, were assigned to g + m treatment (7.5 +/- 1.500 mg) during a 4 months period. during g+m treatment fg (171 +/- ... | 1992 | 1493670 |
| effects of epidermal growth factor, phorbol ester, and retinoic acid on hormone synthesis and morphology in porcine thyroid follicles cultured in collagen gel. | epidermal growth factor (egf), phorbol esters (pes), and retinoic acid (ra) inhibit differentiated functions of thyrocytes. in the present study the inhibitory effects of these growth-promoting factors on hormone synthesis were studied in thyroid follicles cultured in type-i collagen gel, and morphologic alteration by these factors was examined by light and electron microscopy (em). porcine open thyroid follicles obtained by treatment with 0.1% collagenase were embedded in collagen gel and cultu ... | 1992 | 1493378 |
| low-molecular-weight iodoproteins in the congenital goiters of cog/cog mice. | previously we described sedimentation and immunologic abnormalities of thyroglobulin (tg) in a strain of mice with inherited congenital goiter and hypothyroidism (cog/cog). the goals of the present study were to determine the extent to which thyroid gland stimulation by tsh accounts for the abnormal properties of cog/cog tg and to characterize further the abnormally small iodoproteins found in cog/cog mice. cog/cog and control +/cog and balb/c mice were fed with either normal or thyroid-hormone- ... | 1992 | 1493376 |
| expression of the thyroid hormone receptor, the oncogenes c-myc and h-ras, and the 90 kd heat shock protein in normal, hyperplastic, and neoplastic human thyroid tissue. | expression of the thyroid hormone receptor (tr beta), the 90 kd heat shock protein (hsp 90), and the oncogenes h-ras and c-myc mrna in normal hyperplastic, and neoplastic human thyroid tissue was investigated by northern blot and slot blot analyses. the tr beta mrna was present in all normal and neoplastic thyroid tissue samples. the levels were significantly higher in normal and hyperplastic tissues (7.91 +/- 0.48 and 7.60 +/- 0.68 arbitrary units, respectively) than in neoplastic tissues (3.82 ... | 1992 | 1493372 |
| outcome of thyroid function in newborns from mothers treated with amiodarone. | amiodarone, a drug extensively used as an antiarrhythmic agent, contains 37% iodine and causes several thyroid abnormalities. the transplacental passage of amiodarone occurs with chronic therapy; we describe in this report the outcome of 9 pregnant women who used amiodarone (200 mg/day) for treatment of resistant tachycardia and the follow-up of their newborns. all women were clinically euthyroid at the 3rd trimester and showed expected values of thyroid hormones (mean +/- sd: total t4, 228 +/- ... | 1992 | 1493368 |
| [multivisceral resection of colorectal cancer--experiences of the colorectal cancer study group]. | between 1984 and 1986, 2341 patients with colorectal carcinoma from 7 german institutions entered the colorectal carcinoma study group (sgcrc). in 197 of 2053 patients with radical resections, the operation was extended by multivisceral resection. the two groups of patients were comparable in age, preoperative risk factors, postoperative morbidity, and mortality. long-term results showed no statistically significant difference in survival according to the 5-year survival rates, calculated by the ... | 1992 | 1493330 |
| [extended resection in tumor surgery of the lung]. | out of 3823 prospectively followed patients with bronchial carcinoma, 1404 were operated upon. after radical resection, prognoses for 5-year survival in t3 and t4 tumors was 22% and 10%, respectively. resection was carried out in 190 t3 tumors and 202 t4 tumors. indications are based on existing or imminent complications in advanced locoregional tumor growth. surgery must be decided on as palliative treatment in a high number of cases. this kind of surgical tumor management requires sophisticate ... | 1992 | 1493308 |
| [general anesthesia, hormones and hemodynamics during the excision of tumors of the posterior cranial fossa]. | the levels of tropic and peripheral hormones (acth, tsh, sth, t3, t4, hydrocortisone, insulin) have been assessed in 74 patients, aged 16 to 64 years, operated on for posterior cranial fossa tumors. depending on the basic anesthesia component the patients were divided into 3 groups: patients on halothane anesthesia, patients on anesthesia with azeotropic mixture, patients on neuroleptanalgesia. three hemodynamic variants in the course of operation and postoperative period have been established: ... | 1992 | 1492678 |