Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [papillary and follicular thyroid carcinoma: long-term course in 339 patients of the zurich university hospital 1960 to 1988 and review]. | survival rates, tumor control and complications in 339 patients with follicular or papillary carcinoma of the thyroid treated at the clinics of radio-oncology and nuclear medicine during the period 1960-1988 were analyzed. operable tumors were treated by subtotal thyroidectomy or various modes of uni- or bilateral subtotal resection combined with eradication of remaining thyroid tissue with iodine 131 or percutaneous irradiation, the latter limited in the seventies to patients with local or regi ... | 1992 | 1565936 |
| [stage-independence and individual outcome of neuro-cognitive deficits in hiv. a follow-up study of 62 hiv-positive hemophilic patients]. | 62 of a series of 188 hiv-positive hemophiliacs, who had been neuropsychologically evaluated already in 1988 (t1), were re-examined 1 1/2 years later (t2). the aims of the study were to confirm the cross-sectional results of the 1988 study and to compare cross-sectional and longitudinal aspects of hiv infection and associated neurocognitive deficits. patients were staged at t1 and t2 according to cdc classification criteria and retested using parallel tests of attention, verbal/nonverbal memory ... | 1992 | 1565174 |
| [cryptococcosis: presentation of 26 cases]. | cryptococcosis is more frequently observed since the appearance of the acquired immunodeficiency syndrome (aids). aids has modified the clinical and evolutive forms of the disease. this study reviews the changes produced in the infection from the context of aids. | 1992 | 1564965 |
| revision of classification of laryngeal cancer, is it long overdue? (proposals for an improved tn-classification). | the tnm-classification of laryngeal carcinomas of the uicc contains a number of weaknesses which diminish their prognostic relevance. based on clinical observations and microscopic investigations of surgical specimens, several changes are proposed to improve the existing tn-classification. the larynx is subdivided by the uicc into the supraglottic, the glottic and the subglottic main area and their tumours. there are embryological, anatomical, functional and oncological reasons to divide the lar ... | 1992 | 1564374 |
| immunocytochemical demonstration of t4 content and tsh-binding by cells of the thyroid of the developing chick embryo. | the numerical densities (nv) of immunostained thyroxine (t4)-positive cells and thyrotropin-stimulating hormone (tsh)-positive cells were determined in chick embryos on day 5.5 through day 11.5 and days 5.5, 7.5, 9.5, 10.5, 11.5, 12.5, 13.5, 14.5, 15.5, 16.5, and 17.5, respectively. the data demonstrate that selected cells of the "prefollicular" thyroid contain t4 and bind tsh at least as early as day 5.5. the nv of immunocytochemically demonstrable t4-positive cells increases gradually from day ... | 1992 | 1563621 |
| thyroid hormone receptors and iodothyronine deiodinases in the developing mexican axolotl, ambystoma mexicanum. | the mexican axolotl, ambystoma mexicanum, is a neotenous salamander that rarely undergoes anatomical metamorphosis, but can be induced to do so by administration of thyroxine (t4). the neoteny appears to be due primarily to low levels of plasma t4 secondary to a low rate of secretion of thyroid-stimulating hormone. however, other factors may also be involved. in anuran amphibia, metamorphosis is accompanied by alterations in thyroid hormone receptor concentration and marked changes in the activi ... | 1992 | 1563619 |
| changes in whole body concentrations of cortisol, thyroid hormones, and sex steroids during early development of the chum salmon, oncorhynchus keta. | significant amounts of cortisol (20 ng/g) and thyroid hormones thyroxine (t4, 20 ng/g) and triiodothyronine (t3, 10 ng/g), as well as estradiol (8 ng/g) and testosterone (4 ng/g), are present in fertilized eggs of chum salmon. changes in the concentrations of these hormones in the developing embryo and larvae were monitored until after the emergence of the fry from the gravel bed. cortisol concentrations in the developing embryo fell steadily from 20 ng/g at fertilization to 2.5 ng/g after 3 wee ... | 1992 | 1563618 |
| measurement of plasma thyroxine binding protein in relation to thyroidal condition in the turtle, trachemys scripta, by radioimmunoassay. | polyclonal (rabbit) antisera were generated against a high-affinity plasma thyroxine (t4) binding protein (tbp) purified from the turtle, trachemys scripta, and used to develop a specific radioimmunoassay (ria). the ria demonstrated the presence of an immunochemically related protein in the plasma of several other species of trachemys and in members of several other genera from the same family, emydidae. plasma from all nonemydids and some emydid genera either showed no competition or nonparalle ... | 1992 | 1563614 |
| preoperative evaluation of bronchogenic carcinoma: value of mr in t- and n-staging. | seventy consecutive patients with a bronchogenic carcinoma, in whom chest radiographs did not allow a sufficient evaluation of primary tumor localization or extension were examined by mr (1t). all diagnoses were confirmed by operation and histopathologic examination (stage t1: 6 patients, stage t2: 36 patients, stage t3: 19 patients, stage t4: 9 patients). t-staging was correct in 79% of patients. significant infiltration of major bronchi, of the pericardium, heart, mediastinal fat and chest wal ... | 1992 | 1563437 |
| functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome. | we wished to ascertain whether a mutation in the thyroid hormone receptor beta gene was present in a family with generalized thyroid hormone resistance syndrome and to characterize the functional properties of this mutant receptor. | 1992 | 1563081 |
| comparison of hyperbaric solutions of bupivacaine and tetracaine during continuous spinal anaesthesia. | the aim of this study was to compare two equipotent solutions of hyperbaric bupivacaine and tetracaine in 30 elderly patients undergoing elective hip surgery under continuous spinal anaesthesia. with the patient in the supine position, 2 ml (8 mg) of either hyperbaric solution (density 1.030) were administered in a double-blind and randomized fashion. the median maximum sensory and temperature discrimination levels (t5 and t4) were similar with both solutions. the duration of analgesia was not d ... | 1992 | 1563056 |
| epidural fentanyl and caesarean section: when should fentanyl be given? | epidural fentanyl is often added to epidural local anaesthetic agents to improve the quality of anaesthesia obtained during caesarean section. fentanyl may be given either before or after delivery of the infant. when given before delivery, fentanyl has not been reported to cause neonatal depression, although this remains a concern. a prospective, randomized, double-blind study was undertaken to determine if fentanyl was more effective if given before or after delivery of the baby in 64 women und ... | 1992 | 1563055 |
| effects of ascorbic acid on plasma thyroxine concentrations and eggshell quality of leghorn chickens treated with dietary thiouracil. | because ascorbic acid (aa) and the thyroid hormones are known to influence eggshell formation, the effects of aa on body weight, total plasma thyroxine (t4), egg production, and eggshell quality of single comb white leghorn (scwl) hens concurrently and previously treated with thiouracil (tu) were determined. hens were provided feed containing either 0 or 100 ppm aa from 47 to 67 wk of age and either 0 or .1% tu from 47 to 57 wk of age. a three-way split-plot analysis was employed to test for the ... | 1992 | 1561222 |
| [treatment results of radiotherapy for squamous cell carcinoma of the cheek mucosa]. | the results of radiotherapeutic treatment in 71 patients with squamous cell carcinoma of the cheek mucosa were reviewed. the actuarial 5-year local control rate was 100% for t1 (8 patients), 62% for t2 (43), 65% for t3 (17) and 0% for t4 (3). the patients were divided into four groups according to treatment modality; group 1 was treated by radiotherapy alone (r), group 2 by radiotherapy combined with chemotherapy of blm or pep (r + c), group 3 by external radiotherapy followed by surgery (r + s) ... | 1992 | 1561060 |
| [mild hypothermia in patients with senile dementia]. | from the viewpoint of the high frequency of mild hypothermia in patients with senile dementia, we investigated causative factors in comparison with accidental hypothermia. we also investigated the relationship between hypothermia and the type or grade of dementia. a total of 127 demented cases including 30 males and 97 females, whose mean age was 80.6 +/- 8.9 years, were classified into 3 groups according to the axillary temperature measured in august 1989. group a consisted of 33 cases whose bo ... | 1992 | 1560609 |
| specific associations of t4 bacteriophage proteins with immobilized deoxycytidylate hydroxymethylase. | is the enzymatic machinery for dna precursor biosynthesis linked to the dna replication apparatus? to identify intermolecular associations among deoxyribonucleotide biosynthetic enzymes and to ask whether these enzymes are linked to replication proteins, we analyzed radiolabeled t4 bacteriophage proteins that bind specifically to a column of immobilized t4 deoxycytidylate hydroxymethylase. more than a dozen t4 proteins and a few escherichia coli proteins are adsorbed specifically by this column. ... | 1992 | 1560001 |
| behavioral and physiological responses of dairy goats to food thwarting. | eight nubian dairy goat does in one experiment, and eight alpine dairy goat does in a second experiment, were randomly allotted to food-thwarted or fed groups in a crossover experimental design. food thwarting was hypothesized to produce an emotional state analogous to frustration. after a 1-week training period during which the goats of both breeds were conditioned to being simultaneously fed in adjacent feeding stalls, frustration was induced in half the goats by feeding only alternate does. f ... | 1992 | 1557440 |
| behavioral and physiological responses of dairy goats to isolation. | eight nubian and eight alpine dairy goat does were used in a crossover experimental design to determine the effect of 30 min of isolation on behavior and plasma concentrations of thyroxine (t4), triiodothyronine (t3), cortisol, norepinephrine (nor), and epinephrine (epi). isolation was hypothesized to produce an emotional state analogous to fear. focal animal behavior was recorded for the initial five min of isolation. blood samples were obtained via jugular cannulae at 0 (immediately prior), 10 ... | 1992 | 1557439 |
| an internal auu codon initiates a smaller peptide encoded by bacteriophage t4 baseplate gene 26. | bacteriophage t4 baseplate gene 26 codes for two in-frame overlapping peptides with identical c-terminal regions. by site-directed mutagenesis we have now determined that an internal auu, codon 114 of gene 26, is used as the initiation codon for the synthesis of a smaller peptide (gp26*). thus gene 26* gives rise to a peptide of 95 amino acid residues with an mr of 10,873, while the complete gene 26 encodes a peptide of 208 amino acid residues of m(r) 23,880. expression of gene 26* is shown to d ... | 1992 | 1557032 |
| cognitive function in non-demented older adults with hypothyroidism. | (1) to evaluate objectively changes in cognitive function and electrophysiologic characteristics associated with hypothyroidism of varying severity and duration in primarily older persons; (2) to determine whether these changes are reversible when a euthyroid state has been attained after treatment with thyroid hormone. | 1992 | 1556359 |
| activities of two dissimilar thioredoxins from the cyanobacterium anabaena sp. strain pcc 7120. | thioredoxin is a small redox protein that functions as a reducing agent and modulator of enzyme activity. a gene for an unusual thioredoxin was previously isolated from the cyanobacterium anabaena sp. strain pcc 7120 and cloned and expressed in escherichia coli. however, the protein could not be detected in anabaena cells (j. alam, s. curtis, f. k. gleason, m. gerami-nejad, and j. a. fuchs, j. bacteriol. 171:162-171, 1989). polyclonal antibodies to the atypical thioredoxin were prepared, and the ... | 1992 | 1556078 |
| clinical staging: its importance in therapeutic decisions and clinical trials. | international collaboration has resulted in a revised and unified 1987 formulation for the tnm classification in solid tumors. the simplification and eliminations of most variables caused difficulties for the clinical use of the system in some tumors such as bladder cancer. the approval of the proposed adaptation covering the tumor mass, subdividing the t4 category and adapting the stage grouping, resolves these difficulties. published reports demonstrate support for the tnm system as a clinical ... | 1992 | 1556052 |
| enhancement by thyroxine of experimental carcinogenesis induced in rat colon by azoxymethane. | the effect of thyroxine (t4) on the incidence, number and histology of colon tumors induced by azoxymethane (aom), and on the labeling index of colon mucosa were investigated in wistar rats. rats were given aom by injection once a week for 10 weeks, together with t4 in depot form until the end of the experiment. administration of t4 resulted in a significant increase in the incidence of colon tumors in week 35. however, it did not influence the histological appearance of the colon tumors or the ... | 1992 | 1555896 |
| the effects of stress on gastric ulceration, t3, t4, reverse t3 and cortisol in neonatal foals. | sixteen neonatal foals stressed by disease underwent endoscopic examination of their stomachs and blood was assayed for triiodothyronine (t3), reverse t3 (rt3), thyroxine (t4) and cortisol, to determine the effects of severe physiological stress and the occurrence of gastric ulcers. compared with eight age-matched controls, six foals had abnormal cortisol, seven had abnormal t3 and 12 had abnormal t4. eleven of 13 foals had rt3 outside the 95 per cent confidence interval for clinically normal fo ... | 1992 | 1555538 |
| technical report: the post-micturition ct scan as an aid to staging bladder cancer. | the accurate staging of bladder cancer by computed tomography (ct) can be hampered where a bowel loop lies in close proximity to a tumour and the resolution of the system is such that a clearly defined fat plane between tumour and bowel is not visible. this paper describes the use of post-micturition scanning in a case where bowel involvement by tumour was suspected on the initial scans but was subsequently shown to be absent on the post-micturition scans. this technique has the potential, in se ... | 1992 | 1555375 |
| blood serum biochemical changes in physically conditioned and unconditioned subjects during bed rest and chronic hyperhydration. | 1. it has been suggested that prolonged exposure to a rigorous bed rest regimen (hypokinesia) may induce greater serum carbohydrate and electrolyte changes in physically conditioned than unconditional subjects and that chronic hyperhydration may normalize or attenuate the development of these biochemical alterations in physically conditioned subjects. 2. serum carbohydrate and electrolyte changes were determined in 18 physically healthy male volunteers aged 19-24 years during 30 days of a rigoro ... | 1992 | 1555326 |
| squamous carcinoma of the head and neck in the young adult. | we present a series of 2305 previously untreated histologically proven squamous carcinomas of the mucosal surfaces of the upper aerodigestive tract managed by one of us in a 27-year period. 62 (2.7%) of the patients were aged 40 years or younger. the sex ratio between young and old patients was similar but, as expected, the younger patients were in better physical condition. furthermore, 90% of young patients were treated, compared with only 78% of the older patients. younger patients had a high ... | 1992 | 1555311 |
| change of thyroid function in 50 patients with aplastic anemia. | the serum thyroid hormones were measured in 50 patients with aplastic anemia (aa). serum t3 and t4 levels were significantly lower, especially in the elderly and in those in chronic aa, while they were normal in acute aa. there was no obvious difference with thyroid-stimulating hormone (tsh). it was suggested that the result may be caused by euthyroid sick syndrome, a protective adaptation that helps in classifying and evaluating the prognosis of the disease. | 1992 | 1553959 |
| udp-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. | as many microsomal enzyme inducers have been shown to reduce thyroid hormone levels, this study was conducted to determine if this reduction is produced by directly blocking the synthesis of thyroid hormones, or by indirectly increasing the biotransformation and deactivation of thyroxine (t4) by microsomal enzymes. surgically thyroidectomized male rats received thyroid hormone replacement therapy by implanted osmotic minipumps, resulting in t4 and t3 serum levels that were similar to those obser ... | 1992 | 1553754 |
| site-specific incorporation of novel backbone structures into proteins. | a number of unnatural amino acids and amino acid analogs with modified backbone structures were substituted for alanine-82 in t4 lysozyme. replacements included alpha,alpha-disubstituted amino acids, n-alkyl amino acids, and lactic acid, an isoelectronic analog of alanine. the effects of these electronic and structural perturbations on the stability of t4 lysozyme were determined. the relatively broad substrate specificity of the escherichia coli protein biosynthetic machinery suggests that a wi ... | 1992 | 1553546 |
| response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. | six "cavity-creating" mutants, leu46----ala (l46a), l99a, l118a, l121a, l133a, and phe153----ala (f153a), were constructed within the hydrophobic core of phage t4 lysozyme. the substitutions decreased the stability of the protein at ph 3.0 by different amounts, ranging from 2.7 kilocalories per mole (kcal mol-1) for l46a and l121a to 5.0 kcal mol-1 for l99a. the double mutant l99a/f153a was also constructed and decreased in stability by 8.3 kcal mol-1. the x-ray structures of all of the variants ... | 1992 | 1553543 |
| a study of l-thyroxine replacement. | we studied consecutive requests for in vitro thyroid function tests on patients receiving l-thyroxine (t4) for primary hypothyroidism for a three month period may to july 1990, and waited a further three months before ascertaining any changes made to the daily dose of t4. serum sensitive tsh (stsh) concentrations were normalised in only 43% of patients treated by a hospital general physician, 50% of patients treated by a specialist endocrinologist and 52% of patients treated by their primary car ... | 1992 | 1553113 |
| recombinant human immunodeficiency virus type 1 nucleocapsid (ncp7) protein unwinds trna. | the nucleocapsid protein (nc) of all animal retroviruses, encoded by the gag gene, is the major structural protein of the core ribonucleoprotein complex, bound to genomic rna in mature virions. nc is also thought to play one or more accessory roles in reverse transcription. mature nc (p7nc) from human immunodeficiency virus type 1 (hiv-1) is a 71-amino acid, basic protein which contains two cys3his zn(ii) retroviral-type zinc finger domains. herein, we describe the subcloning and expression of h ... | 1992 | 1551877 |
| evidence favouring the hypothesis of a conserved 3'-5' exonuclease active site in dna-dependent dna polymerases. | the complete amino acid (aa) alignment of the n-terminal domain of 33 dna-dependent dna polymerases encompassing the putative segments exo i, exo ii and exo iii, proposed by bernad et al. [cell 59 (1989) 219-228] to form a conserved 3'-5' exonuclease active site in prokaryotic and eukaryotic dna polymerases, allowed us to identify and/or correct some of the most conserved segments (exo i, ii and iii) in certain dna polymerases. in particular, the aa region of t4 dna polymerase and other eukaryot ... | 1992 | 1551594 |
| are there highly conserved dna polymerase 3'----5' exonuclease motifs? | it was proposed by bernad et al. [cell 59 (1989) 219-228] and blanco et al. [gene 100 (1991) 27-38] that the 3'----5' exonuclease (exo) domain of escherichia coli dna polymerase i (poli) is structurally and functionally conserved among prokaryotic and eukaryotic dna polymerases. the basis for this claim is the presence of three short peptide sequences in many dna polymerases that resemble poli sequences that have been shown by x-ray crystallographic and genetic engineering studies to be metal io ... | 1992 | 1551593 |
| the association of silent thyroiditis with active systemic lupus erythematosus. | autoimmune thyroid disorders have been shown to occur in patients with connective tissue diseases. hypothyroidism and thyrotoxicosis have been recognized in systemic lupus erythematosus (sle). moreover, a high prevalence of antithyroid antibodies has been found in patients with sle. we studied thyroid function in a group of sle female patients without a history or clinical diagnosis of thyroid disease and then correlated the prevalence of abnormal function test results with the laboratory indexe ... | 1992 | 1551281 |
| equine thyroid function tests: a preliminary investigation. | a similar and significant (p less than 0.001) increase in plasma thyroxine (t4) concentration was seen in seven clinically normal thoroughbred horses 2 h after the intravenous administration of either 2.5 iu or 5 iu of thyroid stimulating hormone (tsh) with a peak response around 4 h after administration. the intravenous administration of 0.2, 0.5 or 1 mg thyrotrophin releasing hormone (trh) resulted in a significant (p less than 0.01) increase in t4 concentration in three groups of animals; six ... | 1992 | 1551018 |
| trypanosome-induced hypothyroidism in cattle. | three boran (bos indicus) cattle infected with t. congolense il 1180, and two uninfected control boran cattle were used to study the effect of trypanosomiasis on the function of the thyroid gland. on a weekly basis, plasma thyroxine (t4) was measured by 125i-radioimmunoassay. results indicated that t. congolense caused a significant decline in plasma t4 concentration in infected animals. | 1992 | 1551017 |
| 2'-amino-2'-deoxyguanosine is a cofactor for self-splicing in group i catalytic rna. | in investigations on self-splicing in the group i intron of the pre-mrna from the nrdb gene of bacteriophage t4 it was found that 2'-amino-2'-deoxyguanosine can replace guanosine as cofactor. this is the first guanosine-analogue with a modification in the 2'-position and substantial activity in a group i self-splicing reaction. the results suggest that the 2'-amino and 2'-hydroxy groups of the cosubstrates have some properties in common, which are important for binding as well as for catalysis. | 1992 | 1550590 |
| identification of a specific inhibitor for dna ligase i in human cells. | a protein inhibitor for human dna ligase i has recently been identified. it was copurified with a fraction of the enzymes from hela cells through several steps of chromatography. the inhibitor was first identified by the absence of ligation activity of the associated enzyme, while it retained the ability to form the ligase-[32p]amp adducts. the inhibitor was eluted as a single peak at approximately 0.25-0.30 m nacl from a mono s column. it inhibited the ligation of both double-stranded and singl ... | 1992 | 1549587 |
| effect of suspending exercise training on resting metabolic rate in women. | we tested the hypothesis that enhanced resting metabolic rate (rmr) in highly trained endurance athletes is an acute effect of prior exercise induced by catecholamines and not serum thyroxine. rmr and energy-regulating hormones were studied in nine highly trained women runners during habitual training (period i), and suspension of training (period ii). data were collected during the follicular phase of two consecutive menstrual cycles, confirmed by serum progesterone and estradiol. subjects main ... | 1992 | 1548997 |
| the imprecision profile in immunoassay. a study using a resampling technique. | a resampling ('bootstrap') technique was applied to assess the reliability of the calculated imprecision profile (ip), as obtained from the dose/response curve and the response/error relationship (rer) using the cumulative data relative to two assays, i.e. a t4 radioimmunoassay (ria) and a tsh immunofluorometric assay (ifma), both run in duplicate. mean values and the related uncertainty of the estimated dose errors were compared for different rer fitting conditions and different sizes of the du ... | 1992 | 1548403 |
| removal of micro-organisms by filtration through unwoven cloth coated with a pyridinium-type polymer. | unwoven cloth coated with 32 mg/g of a copolymer of n-benzyl-4-vinyl-pyridinium chloride and styrene was found to be effective in removing micro-organisms from water. in experiments demonstrating removal of escherichia coli by filtration through ten sheets of the unwoven cloth, the rate of removal was 99.99% at a filtration rate of 2.6 cm/h, and remained at 99% even at a high filtration rate of 300 cm/h and a low influent concentration of the bacterial cells such as 10(3) cells/ml. the rate of r ... | 1992 | 1547833 |
| hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat. | corticosteroid-binding globulin (cbg) is an acidic glycoprotein produced primarily by the liver and is the major glucocorticoid transport protein in rat blood. various hormone treatments are known to modify plasma cbg levels and may thereby influence the bioavailability of glucocorticoids. we have, therefore, examined serum cbg and hepatic cbg mrna levels in male rats after sc steroid (25 micrograms/100 g bw twice daily of dexamethasone, prednisolone, corticosterone, estrone, estradiol, ethinyl ... | 1992 | 1547738 |
| thyroid hormones precociously increase nerve growth factor gene expression in the submandibular gland of neonatal mice. | the developmental regulation of the expression of nerve growth factor (ngf) was studied in the mouse submandibular gland (smg). having demonstrated that, in the neonatal mouse, maturation of the smg can be accelerated by treatment with thyroid hormones, with the resulting induction in smg content of ngf, studies were undertaken to further examine the locus of thyroid hormone action. because of the sexual dimorphism of the smg, both male and female neonatal mice were used. ngf messenger rna level ... | 1992 | 1547729 |
| evidence for neuromedin-b synthesis in the rat anterior pituitary gland. | neuromedin-b shows a widespread distribution throughout mammalian neural and peripheral tissues and may be involved in the modulation of a variety of physiological processes. the highest concentrations of neuromedin-b are found in the anterior pituitary gland, suggesting that it may be of physiological importance within this tissue. to examine this hypothesis, we have used northern blotting to demonstrate that neuromedin-b is present in the anterior pituitary as a result of local synthesis and h ... | 1992 | 1547712 |
| interaction of the dye ethidium bromide with dna containing guanine repeats. | dna containing one or more copies of the motifs repeated in telomere sequences has unusual conformational properties. the isolated sequence from the protozoan oxytricha, dt4g4 has the potential to form tetramers in the presence of sodium or potassium ions. we report here that these tetramers bind ethidium tightly, with an interaction that fulfills several criteria for an intercalative mechanism in the g sequence. by contrast, the 4-fold tandem repeat of this subunit, d(t4g4)4, does not interact ... | 1992 | 1547228 |
| effect of the (+)-cc-1065-(n3-adenine)dna adduct on in vitro dna synthesis mediated by escherichia coli dna polymerase. | (+)-cc-1065 is a potent antitumor antibiotic produced by streptomyces zelensis. previous studies have shown that the potent cytotoxic and antitumor activities of (+)-cc-1065 are due to the ability of this compound to covalently modify dna. (+)-cc-1065 reacts with duplex dna to form an n3-adenine dna adduct which lies in the minor groove of the dna helix overlapping with a 5-base-pair region. as a consequence of covalent modification with (+)-cc-1065, the dna helix bends into the minor groove and ... | 1992 | 1547223 |
| effect of selenium deficiency on hepatic type i 5-iodothyronine deiodinase activity and hepatic thyroid hormone levels in the rat. | selenium deficiency in rats for a period of up to 6 weeks inhibited both the production of 3,3',5-tri-iodothyronine (t3) from thyroxine (t4) (5'-deiodination) and also the catabolism of t3 to 3,3'-di-iodothyronine (5-deiodination) in liver homogenates. the hepatic stores of t3 were decreased by only 8% in selenium deficiency, despite the t3 production rate from t4 being only 7% of the rate found in selenium-supplemented rats. hepatic glutathione s-transferase (gst) activity was increased in both ... | 1992 | 1546962 |
| [clinical significance of the stereological estimation of mean nuclear volume in human bladder carcinoma--relation to tumor grade, stage and prognosis]. | quantitative analysis of the malignant potential in cancer cells is a method currently under discussion. recently the stereological estimation of cancer cells has been utilized in making an objective and quantitative pathological diagnosis. in this study, we estimated the mean nuclear volume (mnv) of untreated bladder carcinomas in 128 patients by stereological methods and attempted to quantitatively analyze the malignant potential of the carcinoma. the mnv was significantly enlarged as the tumo ... | 1992 | 1546565 |
| v3 loop region of the hiv-1 gp120 envelope protein is essential for virus infectivity. | the mechanism by which hiv-1 mediates cell fusion and penetrates target cells, subsequent to receptor (cd4) binding, is not well understood. however, neutralizing antibodies, which recognize the principal neutralizing determinants of the gp120 envelope protein (the v3 loop region, residues 296 to 331), have been shown to effectively block cell fusion and virus infectivity independent of the initial gp120-cd4 binding. to investigate the role of the v3 loop in an hiv infection, a series of site-sp ... | 1992 | 1546447 |
| quadruplex structure of oxytricha telomeric dna oligonucleotides. | the telomeres of most eukaryotes contain a repeating g-rich sequence with the consensus d(t/a)1-4g1-8, of which 12-16 bases form a 3' single-strand overhang beyond the telomeric duplex. it has been proposed that these g-rich oligonucleotides associate to form four-stranded structures from one, two or four individual strands and that these structures may be relevant in vivo. the proposed structures contain hoogsteen base-paired g-quartets, precedent for which has been in the literature for many y ... | 1992 | 1545871 |
| [tnm classification system in cancer of the submandibular gland--a comprehensive retrospective study of 271 primary cases]. | a total of 271 patients with submandibular gland cancer, treated in 149 hospitals in japan in the period from 1958 to 1991, were retrospectively studied with regard to age, sex, tnm classification (uicc 1987, geneva), histological diagnosis, therapeutic method and prognosis. the results were the following: 1. 157 males and 114 females 2. stage i: 52 cases (19%); stage ii: 64 cases (24%); stage iii: 52 cases (19%) and stage iv: 103 cases (38%). 3. t1: 29 cases (11%); t2:116 cases (43%); t3: 93 ca ... | 1992 | 1545308 |
| diurnal profiles of thyroid hormones are altered in depression. | free thyroxine index (ft4i), serum thyroxine (t4) and thyrotrophin concentrations were measured in 45 depressed subjects and 23 controls. the ft4i am/pm ratio was significantly higher in depressed subjects than in controls. this elevated diurnal ratio of thyroid hormones in depression adds to the literature on the chronobiology of affective disorders, and may help to explain differences in thyroid hormone levels in depressed patients in other studies, where time of sampling has seldom been repor ... | 1992 | 1545041 |
| fluorescence study of the thyroxine-dependent conformational changes in human serum transthyretin. | fluorescence studies of transthyretin (ttr) were conducted to detect structural changes associated with the environment of its two tryptophans, induced by binding of thyroxine (t4). non-radiative tryptophans relaxation rate has an activation energy of 6.4 kcal/mol for ttr, which is decreased to 4.4 kcal/mol for ttr-t4 complex. the maximum fluorescence wavelength was red-shifted as the excitation wavelength was increased. t4 changed the magnitude of this shift. t4 binding per se changed the emiss ... | 1992 | 1544405 |
| regulation of prolactin receptor gene expression by thyroid hormone status in the rat. | the nature and tissue distribution of prolactin receptor (prl-r) mrna in both male and female rats was studied. a single mrna species of 2.2 kb was identified in the liver, kidney, adrenal, prostate, lactating mammary gland and ovary but not in the male lung, heart, skeletal muscle, thymus, adipose tissue or brain. there were distinct and contrasting sex differences in abundance of prl-r mrna in some tissues: liver (female much greater than male), kidney and adrenal (male much greater than femal ... | 1992 | 1543535 |
| inhibition of t4 dna ligase activity by (+)-cc-1065: demonstration of the importance of the stiffening and winding effects of (+)-cc-1065 on dna. | non-denaturing gel electrophoresis analysis demonstrates that the stiffening and winding effects of (+)-cc-1065 produce unusual proximal and distal inhibition of t4 dna ligase-catalysed ligation of covalently modified dna. (+)-cc-1065 is a potent antitumor antibiotic produced by streptomyces zelensis. this drug selectively bonds through n3 of adenine in dna and lies in the minor groove of dna, reacting in a highly sequence-selective manner. previous studies (lee et al., 1991) have shown that (+) ... | 1992 | 1543525 |
| maintenance by androgen and thyroid hormone of androgen-induced convoluted tubular cells in mouse submandibular glands. | injection of 5 alpha-dihydrotestosterone (dht) into castrated adult female mice stimulated the proliferation of a small proportion of the convoluted tubular cells in the submandibular glands. we investigated the effects of dht and thyroxine (t4) on the maintenance of these proliferated convoluted tubular cells. for this, castrated adult female mice that had been treated daily with dht for 3 days and then once with [3h]thymidine, received a first series of daily injections of dht for various peri ... | 1992 | 1543269 |
| endemic goitre in senegal--thyroid function etiological factors and treatment with oral iodized oil. | endemic goitre and its response to orally administered iodized oil has been studied in seven villages 25-30 km south of velingara, eastern casamance, senegal. in 502 adults aged greater than 15 years goitre prevalence was 62% with 18.2% having goitre grade 2 or 3. mean free t4 (ft4) was 11.9 +/- 3.5 (sd) pmol/l and iodine deficiency was confirmed by noting median urinary i of 0.079 mumol/l (14.9 mumol i/mol creatinine) with elevated free t3 (ft3)/ft4 ratios. serum selenium concentrations were no ... | 1992 | 1543020 |
| rational design of substituted tripyrrole peptides that complex with dna by both selective minor-groove binding and electrostatic interaction with the phosphate backbone. | the structures of the compounds we call 3a, 3b, and 3c-compounds that incorporate (i) the tripyrrole peptide of the minor-groove-binding distamycin class of compounds and (ii) polyamine ligands that extend from the minor groove and can interact with phosphodiester bonds--were arrived at by computer-graphics designing by using the x-ray structure of distamycin a complexed in the minor groove of d(cgcaaatttgcg)2. compounds 3a, 3b, and 3c are elaborations of distamycin analog 2, designed for improv ... | 1992 | 1542663 |
| influence of experimental hyperthyroidism on insulin action in growing sheep. | the effects of moderate hyperthyroidism on insulin action were studied in five growing sheep (42 kg live weight [lw]) by the euglycemic hyperinsulinemic clamp technique, with insulin infused at rates of 0.33, 1.00, and 6.00 mu/kg lw/min over successive 2-hour periods. animals were injected with saline (control) or thyroxine (15 micrograms/kg lw/d) for 21 days and measurements performed during the final 7 days of each period. thyroxine (t4) treatment elevated plasma t4 less than threefold and pla ... | 1992 | 1542262 |
| t4 endonuclease vii resolves cruciform dna with nick and counter-nick and its activity is directed by local nucleotide sequence. | endonuclease vii of phage t4 resolves holliday structures in vitro by nicking pairs of strands across the junction. we report here analyses of this reaction between endonuclease vii and a holliday structure analogue, made in vitro from synthetic oligonucleotides. the enzyme cleaves the structure in a non-concerted way and nicks each strand independently. combinations of nicks with counter-nicks in strands across the junction resolve the construct. the specificity of the enzyme for dna secondary ... | 1992 | 1542108 |
| the thyrotrophin-releasing hormone (trh)-like peptides in rat prostate are not formed by expression of the trh gene but are suppressed by thyroid hormone. | thyrotrophin-releasing hormone (trh)-immunoreactive peptides were extracted from rat prostate and divided into two groups by mini-column cation exchange chromatography. the amounts of the peptides in each group were determined by radioimmunoassay with a trh antiserum. the unretained peptides which lacked a basic group and the retained peptides which possessed a basic group were further purified by high-performance liquid chromatography. the unretained fraction was found to contain a series of tr ... | 1992 | 1541917 |
| age-dependent variation in response to tubocurarine in the isolated rat diaphragm. | the ec50 of tubocurarine was determined in phrenic nerve-hemidiaphragm preparations obtained from 35 sprague-dawley rats aged 0-46 days. we measured also the ratio of the fourth to the first twitch in the train-of-four (t4:t1) when the first twitch of the train was depressed to 50% of control. the preparation was not unduly sensitive to tubocurarine at 0 days and there was little evidence of t4:t1 fade. however, by age 11 days the preparation exhibited fade and a three-fold sensitivity to tubocu ... | 1992 | 1540457 |
| ontogeny of ia+ accessory cells in fetal and newborn rat lung. | in the adult mammalian lung, ia+ dendritic cells (dc) constitute a significant population of immunologically potent accessory cells that are important in the regulation of immune responses to inhaled antigens. the newborn, in most species, displays an increased susceptibility to sensitization by inhaled antigens; whether an immaturity of pulmonary accessory cells is involved has not been determined. in the present study, the ontogeny and function of these cells were examined in fetal and newborn ... | 1992 | 1540399 |
| biological activities of rabbit antibodies against synthetic human thyrotropin receptor peptides representing thyrotropin binding regions. | recently, we have shown that the thyrotropin (tsh) binding regions of human thyrotropin receptor (tshr) reside in two areas within residues 12-44 and 308-344. serial antisera were raised against four overlapping synthetic peptides representing these two regions of tshr (peptides 12-30, 24-44, 308-328, and 324-344) and were investigated for their ability to stimulate or block the cultured porcine thyroid cells. in addition, serum concentrations of triiodothyronine (t3) and thyroxine (t4) in seria ... | 1992 | 1540180 |
| trh protection against memory retrieval deficits is independent of endocrine effects. | an electrobrainshock (ebs)-induced memory retrieval deficit was produced in normal and hypophysectomized mice. in normal mice, thyrotropin-releasing hormone (trh) (0.1 to 30 mg/kg) protected against this ebs disruption of memory after intraperitoneal but not oral (1.0 to 100 mg/kg) administration. in hypophysectomized mice, trh (0.3 and 3.0 mg/kg) also protected against the retrieval deficit induced by ebs. the memory protection afforded by trh was unrelated to its ability to elevate plasma leve ... | 1992 | 1539064 |
| abnormal thyroid function test results in patients taking salsalate. | to evaluate how the nonsteroidal anti-inflammatory agent salsalate affects the results of routine thyroid function tests. | 1992 | 1538562 |
| an evaluation of two activated clotting time monitors during cardiac surgery. | the activated clotting time (act) is a commonly used method for assessing the degree of anticoagulation during cardiac surgery. two automated act monitors were evaluated in 29 adult patients undergoing cardiac surgery. the hemotec act monitor (htc; hemotec, inc., englewood, co) was evaluated using 0.8 ml of whole blood in dual-chamber, high range kaolin cartridges. the hemochron act monitor (hch; international technidyne, inc, edison, nj) was evaluated using 2.0 ml of whole blood in glass tubes ... | 1992 | 1538250 |
| effects of prednisone on thyroxine and 3,5,3'-triiodothyronine metabolism in normal dogs. | pharmacological doses of glucocorticoids may reduce serum t4 and t3 levels in normal dogs and humans due to hypothalamic-pituitary suppression and/or altered peripheral hormone metabolism. to evaluate the chronic effects of antiinflammatory doses of glucocorticoids on peripheral thyroid hormone metabolism, serum t4 and t3 kinetic studies were performed in five thyroidectomized l-t4-replaced (5 micrograms/kg, sc, daily) normocalcemic male dogs at baseline and after 35 days of oral prednisone (0.5 ... | 1992 | 1537315 |
| thyroxine (t4) transport and distribution in rats treated with emd 21388, a synthetic flavonoid that displaces t4 from transthyretin. | to test whether plasma transthyretin (ttr) might play a specific direct role in the transfer of t4 from the plasma to tissues, in vivo kinetic studies were performed in control rats and in rats treated with emd 21388, a synthetic flavonoid that displaces t4 from ttr. the plasma disappearance curves of simultaneously injected [125i]t4 and [131i]albumin were analyzed to determine the rate constant for the transfer of t4 from the extracellular compartment to the rapidly exchangeable intracellular c ... | 1992 | 1537302 |
| stereochemical requirements for the modulation by retinoic acid of thyroid hormone activation of ca(2+)-atpase and binding at the human erythrocyte membrane. | physiological concentrations of retinoic acid can block the activation of human erythrocyte ca(2+)-atpase in vitro by thyroid hormone [smith, davis & davis (1989) j. biol. chem. 264, 687-689]. the present studies were undertaken to ascertain the nature of this blockade. two binding sites for l-thyroxine (t4) were demonstrated on washed erythrocyte membranes; the high-affinity site had a kd value of 2.7 x 10(-10)m and a bmax. of 76 fmol/mg of protein. the lower-affinity site possessed a kd of 1 x ... | 1992 | 1534654 |
| [clinical problems created by the presence of anti-t3 and anti-t4 antibodies]. | 1992 | 1534620 | |
| dna inversion regions min of plasmid p15b and cin of bacteriophage p1: evolution of bacteriophage tail fiber genes. | plasmid p15b and the genome of bacteriophage p1 are closely related, but their site-specific dna inversion systems, min and cin, respectively, do not have strict structural homology. rather, the complex min system represents a substitution of a cin-like system into an ancestral p15b genome. the substituting sequences of both the min recombinase gene and the multiple invertible dna segments of p15b are, respectively, homologous to the pin recombinase gene and to part of the invertible dna of the ... | 1992 | 1534556 |
| the neurospora cyt-18 protein suppresses defects in the phage t4 td intron by stabilizing the catalytically active structure of the intron core. | the neurospora cyt-18 protein, a tyrosyl-trna synthetase, which functions in splicing group i introns in mitochondria, promotes splicing of mutants of the distantly related bacteriophage t4 td intron. in an in vivo assay, wild-type cyt-18 protein expressed in e. coli suppressed mutations in the td intron's catalytic core. cyt-18-suppressible mutations were also suppressed by high mg2+ or spermidine in vitro, suggesting they affect intron structure. both the n- and c-terminal domains of cyt-18 ar ... | 1992 | 1533818 |
| distribution of leukocyte subpopulations in the human corpus luteum. | cytokines, as secreted products of leukocytes, have roles in many organs of the body via paracrine or autocrine mechanisms. in the present study, we demonstrate by immunocytochemistry the leukocytes present in the human corpus luteum in order to investigate further the relationship between leukocytes, cytokines and corpus luteum function. ten intact corpora lutea were collected from female patients who had no apparent ovarian disease. the mean age of these patients was 37 years (range 23-55 year ... | 1992 | 1533647 |
| growth hormone deficiency in down's syndrome children. | down's syndrome (ds) children have been reported to have severe postnatal growth arrest and microcephaly. to determine if growth hormone (gh) deficiency plays a role in growth retardation in ds, 20 children were studied. the subjects (13 boys, 7 girls) were aged between 15 months and 13.9 years, had a height sds ranging from -1.19 to -5.48, weight sds ranging from -0.21 to -4.58, head circumference sds ranging from -0.40 to -6.6, and a skeletal age ranging from 0.9 to 4.6 sd below the mean for n ... | 1992 | 1533556 |
| "train-of-four" fade during clinical nondepolarizing neuromuscular block. | previous clinical studies on the train-of-four (tof) fade have used different recording techniques, anesthesia agents and muscles for measurement, thus comparison of the results has become difficult. on 49 surgical patients divided into 6 groups, we compared: 1) the tof fade ratios (t4/t1) produced by d-tubocurarine (dtc), pancuronium (p), atracurium (a), and vecuronium (v) and 2) the influence of previously given suxamethonium on tof ratios (dtc and p). neuromuscular block (nmb) was monitored s ... | 1992 | 1533392 |
| immunohistologic study of t-cell receptor delta-chain expression in rheumatoid synovial membranes. | lymphocytes expressing gamma delta t-cell receptors (tcrs) have been shown to be reactive to mycobacterial antigens as well as the so-called stress proteins. the detection of increased numbers of gamma delta cells in the synovial fluid and peripheral blood of some patients with rheumatoid arthritis has suggested a potential role for these lymphocytes in the pathogenesis of this disorder. twenty-three rheumatoid synovial membranes were studied using immunohistology and monoclonal antibodies in an ... | 1992 | 1533291 |
| mivacurium infusion during nitrous oxide-isoflurane anesthesia: a comparison with nitrous oxide-opioid anesthesia. | to determine the potentiation of the neuromuscular blockade induced by a titrated infusion of mivacurium in the presence of isoflurane versus a nitrous oxide (n2o)-opioid anesthesia. | 1992 | 1532895 |
| cryoelectron microscopic visualization of functional subassemblies of the bacteriophage t4 dna replication complex. | a specific complex of proteins involved in bacteriophage t4 replication has been visualized by cryoelectron microscopy as distinctive structures in association with dna. formation of these structures, which we term "hash-marks" for their characteristic appearance in association with dna, requires the presence of the t4 polymerase accessory proteins (the products of t4 genes 44, 45 and 62), atp and appropriate dna cofactors. atp hydrolysis by the dna-stimulated atpase activity of the accessory pr ... | 1992 | 1532838 |
| impaired response to recombinant hepatitis b vaccine in hiv-infected persons. | we studied the immunogenicity of the standard schedule of recombinant hepatitis b vaccine (20 micrograms per dose at months 0, 1, and 6) in 21 anti-human immunodeficiency virus (hiv)-positive persons. relatively low titers of anti-hbs developed in only five subjects (23.8%) 1 month after the third dose; all five had t4 cell counts greater than 700 cells/mm and none of the 11 subjects with a t4 cell count below this value responded. five of the 16 nonresponders to the vaccine later had acquired i ... | 1992 | 1532609 |
| functional cloning vectors for use in directional cdna cloning using cohesive ends produced with t4 dna polymerase. | this paper describes the construction of 'prime' cloning vectors, which include phage lambda and plasmid vectors useful for functional cloning in oocytes, yeast, and mammalian cells, and their use in a 'prime' cloning system. the system takes advantage of the very active and precise 3' exonuclease activity of t4 dna polymerase to produce single-stranded (ss) ends (cut-back) of vector and insert dna. this results in the highly efficient directional cloning of cdna and pcr-amplified dna. the syste ... | 1992 | 1532564 |
| [thyroid function in children with down's syndrome]. | the aim of the present study was to evaluate thyroid function in 45 down's syndrome patients in order to verify the hypothesis of an increased risk of thyroid disorders associated with trisomy 21. a patient with subclinical hypothyroidism (tsh 16.6 microu/ml; t4 6.4 micrograms/dl) was diagnosed in a group of 28 subjects with down's syndrome studied at a mean age of 6 years and 5 months using t3, t4, ft3, ft4, tsh assays and clinical examination. t4 and tsh values were also measured in 10 of thes ... | 1992 | 1532438 |
| epidural lidocaine with sufentanil and epinephrine for abdominal hysterectomy under general anaesthesia: respiratory depression and postoperative analgesia. | the purpose of this investigation was to compare the analgesic actions and side-effects of a 50 micrograms epidural bolus of sufentanil and 50 micrograms epinephrine, with a control group receiving saline and epinephrine. the method employed was a prospective, randomised, double-blind trial involving 40 asa i or ii patients for total abdominal hysterectomy. all received 1.5% lidocaine with 1/200,000 epinephrine epidurally before operation, until a block to t4 was established. patients were anaes ... | 1992 | 1532350 |
| [prevalence of anti-t3 and anti-t4 antibodies. value of their detection]. | 1992 | 1532090 | |
| [pregnancy in hiv infected women. current therapeutic indications]. | this paper deals with the management of pregnant women with hiv infection. the virus is transmitted by the mother to 20-30 percent of the infants, and therapeutic abortion should be offered to women whose pregnancy does not exceed 26 weeks of amenorrhoea. if pregnancy is pursued, the mother must be investigated for sexually transmitted diseases which are particularly frequent in this population and may have repercussions on the newborn. pneumocystis carinii pneumonia is the most common opportuni ... | 1992 | 1532074 |
| dna sequences of the tail fiber genes of bacteriophage p2: evidence for horizontal transfer of tail fiber genes among unrelated bacteriophages. | we have determined the dna sequence of the bacteriophage p2 tail genes g and h, which code for polypeptides of 175 and 669 residues, respectively. gene h probably codes for the distal part of the p2 tail fiber, since the deduced sequence of its product contains regions similar to tail fiber proteins from phages mu, p1, lambda, k3, and t2. the similarities of the carboxy-terminal portions of the p2, mu, ann p1 tail fiber proteins may explain the observation that these phages in general have the s ... | 1992 | 1531648 |
| coordinated leading- and lagging-strand synthesis at the escherichia coli dna replication fork. iii. a polymerase-primase interaction governs primer size. | studies with a rolling-circle dna replication system reconstituted in vitro with a tailed form ii dna template, the dna polymerase iii holoenzyme (pol iii he), the escherichia coli single-stranded dna binding protein, and the primosome, showed that within the context of a replication fork, the oligoribonucleotide primers that were formed were limited to a length in the range of 9 to 14 nucleotides, regardless of whether they were subsequently elongated by the lagging-strand dna polymerase. this ... | 1992 | 1531480 |
| effect of escherichia coli nusg function on lambda n-mediated transcription antitermination. | the escherichia coli nus factors act in conjunction with the bacteriophage lambda n protein to suppress transcription termination on the lambda chromosome. nusa binds both n and rna polymerase and may also interact with other nus factors. to search for additional components of the n antitermination system, we isolated host revertants that restored n activity in nusa1 mutants. one revertant, nusg4, was mapped to the rif region of the e. coli chromosome and shown to represent a point mutation near ... | 1992 | 1531224 |
| hypothalamo-hypophysial-thyroid axis in streptozotocin-induced diabetes. | diabetes mellitus is frequently associated with reduced levels of tsh, prl, gh, and gonadotropins. in this study we have wanted to determine whether chemically induced diabetes mellitus is associated with a decreased hypothalamic release of trh. male rats were made diabetic with streptozotocin (stz; 65 mg/kg), whereas controls received vehicle. after 2 weeks, stz diabetic rats had 25% lower body weights, 3.5-fold higher blood glucose, and 40-60% lower plasma tsh, t3, and t4 levels than controls. ... | 1992 | 1530781 |
| [neoadjuvant chemotherapy (m-vac) for locally invasive bladder cancer]. | eight patients with locally invasive bladder cancer (stages t2-t4, n0, m0; 7 men and 1 woman; mean age, 72.0 years; age range, 56 to 80 years) were treated with 2 cycles of neoadjuvant chemotherapy consisting of methotrexate, vinblastine, adriamycin and cisplatin (m-vac). seven of them underwent radical cystectomy after chemotherapy, while the bladder was preserved in one patient. seven patients were free of disease during a mean follow-up period of 26.2 months (range 20-30 months). however, one ... | 1992 | 1529813 |
| role of ovarian sex steroids in the regulation of thyrotropin (tsh) secretion of hypogonadal women. | the exact role of ovarian sex steroids in the neuroendocrine regulation of thyrotropin (tsh) release in women can only be accurately assessed in the absence of any considerable ovarian sex steroid feedback upon the hypothalamic-pituitary unit. consequently, the unstimulated episodic and thyrotropin-releasing hormone (trh) stimulated tsh secretion was evaluated in postmenopausal women before and during sequential ovarian sex steroid replacements. seven euthyroid women (mean age: 59.4 years) were ... | 1992 | 1529659 |
| the role of maternal thyroid hormones in maintaining early pregnancy in threatened abortion. | to evaluate a possible role of thyroid hormones in maintaining early pregnancy, serum levels of thyroid hormones, tsh and thyroxine-binding globulin (tbg) in 32 patients with a clinical diagnosis of threatened abortion were compared between two groups of patients with favorable and unfavorable pregnancy outcome. serum levels of t4, t3, free t4 and free t3 levels determined at the onset of clinical signs of threatened abortion were found to be significantly lower in patients (n = 11) who subseque ... | 1992 | 1529657 |
| impaired thyroid hormone status and thermoregulation during cold exposure of zinc-deficient rats. | forty-five male, weanling sprague-dawley rats were matched by weight into three groups (n = 15). one group was fed ad libitum a semipurified diet containing all essential nutrients and 30 ppm of zinc (control). a second group was fed ad libitum a similar diet but with a deficient zinc intake of less than 1 ppm (znd). a third group was pair-fed (pf) the control diet in amounts equal to that consumed by the matched znd animals. after 42 days, the animals were fasted for 12 hr then five animals fro ... | 1992 | 1526622 |
| growth hormone acutely decreases type iii iodothyronine deiodinase in chicken liver. | growth hormone (gh) increases plasma t3 and decreases plasma t4 in 18-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. the in vivo increase in t3 can be linked to an increased in vitro t3 recovery from liver homogenates incubated with t4. specific type i and type iii deiodinase tests (5'd-i and 5d-iii), however, show that gh has no effect at all on the amount of hepatic type i enzyme (catalyzing t4 deiodination to t3) but acutely decreases the am ... | 1992 | 1526283 |
| time-related effects of thyrotropin-releasing hormone (trh) on the pituitary-thyroid axis and extrathyroidal targets. | thyrotropin-releasing hormone (trh) is a tripeptide and acts as a stimulator of the pituitary-thyroid axis as well as having a great number of well defined extrathyroidal functions. studies in experimental animals have shown, that trh also has a role as a neuromodulator within the autonomous nervous system. in this study we analyzed the effects following peripheral administration of trh (200 micrograms, 400 micrograms) in patients with endocrinological disorders and in healthy females and males. ... | 1992 | 1526263 |
| biologic markers in blood reflecting thyroid hormone effect at peripheral tissue level in patients receiving levothyroxine replacement for hypothyroidism. | plasma fibronectin, serum procollagen-iii-peptide and sex-hormone binding globulin as not specific markers of thyroid hormone effect at peripheral tissue level were determined and their values were related with serum levels of tsh, free-thyroxine and triiodothyronine during levothyroxine sodium replacement therapy for hypothyroidism. low levels of biologic markers characteristic of hypothyroidism were normalized in consequence of hormone replacement and a negative correlation between their serum ... | 1992 | 1526260 |
| evaluation of the boehringer mannheim es 300 immunoassay analyzer and comparison with enzyme immunoassay, fluorescence polarization immunoassay, and radioimmunoassay methods. | the es 300 (boehringer mannheim diagnostics, indianapolis, in) is a new automated immunoassay analyzer intended for the quantitative determination of a wide range of analytes. we compared its performance to enzyme immunoassay (eia), fluorescence polarization immunoassay (fpia), and radioimmunoassay (ria) methods for cortisol, digoxin, ferritin, prolactin, t4-uptake, total-t3, and tsh. the es 300 methods showed excellent precision and the manufacturers' linearity claims were met in all cases. cor ... | 1992 | 1525980 |
| monitoring thyroxine treatment during pregnancy. | data were analyzed from 77 pregnancies in 65 hypothyroid women treated with levothyroxine (t4) to determine (a) how often, how severely, and when serum thyrotropin (tsh) and free t4 concentrations become abnormal during pregnancy in women taking constant t4 doses and (b) how much to increase t4 doses to normalize elevated serum tsh levels. group i consisted of 36 women with previous thyroid ablation. group ii consisted of 29 women with hashimoto's thyroiditis. serum tsh levels rose above normal ... | 1992 | 1525583 |