Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| optic neuritis following epstein-barr virus encephalitis in immunocompetent children: a case report. | 2017 | 26073488 | |
| successful immunosuppressive therapy for severe infectious mononucleosis in a patient with clonal proliferation of ebv-infected cd8-positive cells. | a 30-year-old woman was diagnosed with severe infectious mononucleosis (im). the epstein-barr virus (ebv) had infected both cd19- and cd8-positive cells, and clonal proliferation of ebv-infected cells and t-cells was detected. although we suspected malignant lymphoma, her condition improved following immunosuppressive therapy. a similar case was recently reported; therefore, this case is the second case of im with ebv-infected cd8-positive cells and clonal proliferation of ebv-infected cells. ou ... | 2015 | 26073246 |
| slow progression of poorly differentiated gastric carcinoma associated with epstein-barr virus infection: 12-year follow-up. | epstein-barr virus (ebv)-associated gastric carcinoma accounts for nearly 10% of all gastric carcinomas and has distinct demographic, clinical and pathological features compared with ebv-negative gastric carcinoma. we herein report the case of a patient with ebv-associated gastric carcinoma followed up for 12 years during the natural course of the disease. the appearance of the tumor on gastroscopy and computed tomography gradually changed, and the size of the lesion increased very slowly during ... | 2015 | 26073239 |
| prevalence of several herpesviruses and human papillomavirus in acute apical abscesses. | to investigate and compare the radiographic size of acute apical abscess lesions for the presence of epstein-barr virus (ebv), human cytomegalovirus (hcmv), human herpesvirus-6 (hhv-6) and human papillomaviruses (hpv) dna by means of the real-time polymerase chain reaction (pcr) method. | 2016 | 26073223 |
| serostatus of epstein-barr virus in iranian ms patients. | multiple sclerosis (ms) is a common, complex disorder. associations of ms with epstein-barr virus (ebv) infection in caucasian populations are well documented. however, in the iranian population, previous studies have been conflicting. sixty patients with ms and 50 healthy controls were tested for anti-ebv antibodies using chemiluminescent assays. all ms patients to be seropositive for ebv as compared to 82 % of controls (p = 0.0006). a strong, significant association of ms with ebv infection wa ... | 2016 | 26071762 |
| human polyomavirus 6 dna in the cerebrospinal fluid of an hiv-positive patient with leukoencephalopathy. | leukoencephalopathies in haart-treated, hiv-positive patients include progressive multifocal leukoencephalopathy (pml), a result of lytic infection oligodendrocytes by jc polyomavirus (jcv), and another form characterized by the absence of jcv genome in cerebrospinal fluid (csf). | 2015 | 26071330 |
| multiparameter analysis of homogeneously r-chop-treated diffuse large b cell lymphomas identifies cd5 and foxp1 as relevant prognostic biomarkers: report of the prospective sakk 38/07 study. | the prognostic role of tumor-related parameters in diffuse large b cell lymphoma (dlbcl) is a matter of controversy. | 2015 | 26071053 |
| vasculitis: an unusual manifestation in an hiv-infected patient. | human immunodeficiency virus (hiv) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. we describe a patient who developed manifestations suggestive of extremities vasculitis with no identifiable risk factors other than hiv, epstein barr and herpes simplex virus (hsv) type 1 co-infection. physicians should be aware that vasculitis may have a heterogeneous presentation and occur associated with hiv infection. although unusual, this asso ... | 2015 | 26070539 |
| ebv bart micrornas target multiple pro-apoptotic cellular genes to promote epithelial cell survival. | epstein-barr virus (ebv) is a ubiquitous human γ-herpesvirus that can give rise to cancers of both b-cell and epithelial cell origin. in ebv-induced cancers of epithelial origin, including nasopharyngeal carcinomas (npcs) and gastric carcinomas, the latent ebv genome expresses very high levels of a cluster of 22 viral pre-mirnas, called the mir-barts, and these have previously been shown to confer a degree of resistance to pro-apoptotic drugs. here, we present an analysis of the ability of indiv ... | 2015 | 26070070 |
| epstein-barr virus-associated nephrotic syndrome. | acute infection with epstein-barr virus (ebv) causes fever, fatigue and pharyngitis. renal involvement in systemic ebv infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. rarely, ebv infection causes nephrotic syndrome due to minimal change disease. a 22-year-old male with infectious mononucleosis (im) presented with nephrotic syndrome. renal biopsy showed minimal change disease with diffuse foot process effacement of the podocytes. treatment with methylpred ... | 2012 | 26069749 |
| isolated unilateral soft palate palsy following tonsillopharyngitis caused by epstein-barr virus infection. | soft palate palsy with or without pharyngeal or laryngeal paralysis or facial palsy has been described in the literature fewer than 40 times. of these cases, isolated unilateral soft palate palsy (occurring without any other neurologic manifestation) has been rare. most cases of isolated soft palate palsy were termed idiopathic in the past. in a few cases, a concomitant viral infection such as varicella zoster, herpes simplex, measles, and coxsackie a9 was diagnosed. we describe a case of isolat ... | 2015 | 26068386 |
| frequency of epstein--barr virus infection as detected by messenger rna for ebna 1 in histologically proven gastric adenocarcinoma in patients presenting to a tertiary care center in south india. | epstein-barr virus (ebv)-associated gastric carcinoma is a relatively uncommon entity detected in approximately 10% of gastric adenocarcinoma. | 2015 | 26068337 |
| human parechovius and enterovirus in neonates: distinct infections with overlapping features. | human parechoviruses (hpevs) have recently been added to the family picornaviridae, where enteroviruses (hev) belong. the specific characteristics of hpev infection in the neonate are not clear, and their involvement in neonatal infection is believed to be largely underestimated. hpev type 3 has been recently linked to sepsis-like illness and neurological involvement in the newborn. | 2015 | 26067868 |
| loss of arid1a expression is related to gastric cancer progression, epstein-barr virus infection, and mismatch repair deficiency. | the at-rich interactive domain 1a (arid1a) gene encodes a member of the switch/sucrose nonfermentable (swi-snf) chromatin remodeling complex, and is considered to work as a tumor suppressor in concert with p53. we investigated the clinical significance of arid1a protein expression in gastric cancer (gc), and examined its association with epstein-barr virus-associated (ebv) gc, mismatch repair (mmr) deficiency, and p53 alteration. we performed immunohistochemistry for arid1a in 417 gc specimens u ... | 2016 | 26067140 |
| latent membrane protein lmp2a impairs recognition of ebv-infected cells by cd8+ t cells. | the common pathogen epstein-barr virus (ebv) transforms normal human b cells and can cause cancer. latent membrane protein 2a (lmp2a) of ebv supports activation and proliferation of infected b cells and is expressed in many types of ebv-associated cancer. it is not clear how latent ebv infection and cancer escape elimination by host immunity, and it is unknown whether lmp2a can influence the interaction of ebv-infected cells with the immune system. we infected primary b cells with ebv deleted fo ... | 2015 | 26067064 |
| humoral responses to diverse autoimmune disease-associated antigens in multiple sclerosis. | to compare frequencies of autoreactive antibody responses to endogenous disease-associated antigens in healthy controls (hc), relapsing and progressive ms and to assess their associations with clinical and mri measures of ms disease progression. | 2015 | 26065913 |
| adoptive therapy for ebv-induced cancers: driving success with post-transplant lymphoproliferative disorder to other ebv-derived tumors. | epstein-barr virus (ebv) infection is associated with a range of human malignancies of lymphocytic and epithelial cell origin. in addition to viral-mediated and genetic oncogenic events that lead to the establishment of ebv-associated malignancies, defects in the immune control of ebv likely play a significant role in promoting the survival of malignant cells. this breakdown in immune surveillance is most evident in immunocompromised transplant patients who are susceptible to the development of ... | 2015 | 26065480 |
| acute kidney injury complicated epstein-barr virus infection in infancy. | infectious mononucleosis is an acute lymphoproliferative disorder caused by the epstein-barr virus (ebv) and seen most commonly in children and young adults. clinical presentation of the disease is characterized by fever, tonsillopharyngitis, lymphadenopathy, and hepatosplenomegaly, whereas serological findings of this benign disorder include positive heterophilic antibody formation (transient increase in heterophilic antibodies) and prominence of hematological lymphocytosis of more than 10% of ... | 2015 | 26064752 |
| high grade (large cell) neuroendocrine carcinoma of the nasopharynx: novel case report with touch preparation cytology and positive ebv encoded early rna. | fewer than five case reports of primary large cell neuroendocrine carcinoma of the nasopharynx are known to the authors. no previous reports have included examples of cytomorphology or have proven association with epstein-barr virus. we herein illustrate mri findings, histopathologic features, immunohistochemical characterization, cytologic details, and in situ hybridization studies from a unique case of primary large cell neuroendocrine carcinoma of the nasopharynx in a 38-year-old caucasian ma ... | 2015 | 26064748 |
| young adult onset systemic epstein-barr virus-positive t-cell lymphoproliferative disorders of childhood. | a 20-year-old woman had a fever, pancytopenia, and liver failure, and was suspected to be suffering from chronic active epstein-barr virus (ebv) infection, based on the detection of high ebv-dna and ebv antibody titers at another hospital. at our institution one month later, clinical manifestations had diminished, and antibody titers had decreased but remained elevated relative to normal levels. four days later, the patient required hospitalization due to fever, liver damage, and cervical lympha ... | 2015 | 26062673 |
| epidemiology of infectious meningitis in the state of amazonas, brazil. | in the state of amazonas, particularly in the capital manaus, meningitis has affected populations of different cultures and social strata over the years. bacterial meningitis is caused by several different species and represents a major issue of public health importance. the present study reports the meningitis case numbers with different etiologies in amazonas from january 1976 to december 2012. | 2015 | 26061374 |
| high cytokine levels in tonsillitis secretions regardless of presence of beta-hemolytic streptococci. | acute pharyngotonsillitis denotes tonsillar inflammation caused by bacteria or viruses. here, we investigated if beta-hemolytic streptococci (β-hs) tonsillitis would differ in inflammatory mediator response from tonsillitis of other causes. tonsillar secretions were obtained from 36 acute pharyngotonsillitis patients and 16 controls. bacteria were cultured quantitatively and 18 different viruses were quantified by real-time polymerase chain reaction. cytokine and prostaglandin e2 (pge2) levels w ... | 2015 | 26060912 |
| quercetin-induced apoptosis prevents ebv infection. | epstein-barr virus (ebv) is a human gamma-1 herpesvirus that establishes a lifelong latency in over 90% of the world's population. during latency, virus exists predominantly as a chromatin-associated, multicopy episome in the nuclei of a variety of tumor cells derived from b cells, t cells, natural killer (nk) cells, and epithelial cells. licorice is the root of glycyrrhiza uralensis or g. glabra that has traditionally cultivated in eastern part of asia. licorice was reported to have anti-viral, ... | 2015 | 26059439 |
| [clinical case. chronic gastritis associated with helicobacter pylori and epstein-barr virus]. | the article describes a clinical case of chronic gastritis associated with helicobacter pylori infection and epstein-barr virus. the authors draw attention to the peculiarities of dyspepsia syndrome, on the characteristics of this disease in the endoscopic and morphological study. | 2014 | 26058116 |
| bhrf1 exerts an antiapoptotic effect and cell cycle arrest via bcl-2 in murine hybridomas. | apoptosis has been widely studied in order to find methods to increase the life-span and production performance in large-scale animal cell cultures. the use of anti-apoptotic genes has emerged as an efficient method to reduce apoptosis in a variety of biotechnological relevant cell lines, including cho and hybridomas, alternatively to small molecule inhibitors. it is already known that expression of bhrf1, an epstein-barr virus-encoded early protein homologous to the anti-apoptotic protein bcl-2 ... | 2015 | 26057602 |
| the epstein-barr virus brrf2 gene product is involved in viral progeny production. | the epstein-barr virus (ebv) predominantly establishes a latent infection in b lymphocytes, and occasionally switches from the latent state to the lytic cycle. in this report, we identified and examined the role of a lytic gene, brrf2. we first prepared an antibody against brrf2 and identified the gene product as a viral lytic protein expressed in b95-8 cells with late kinetics. immunofluorescence revealed that brrf2 localized in the cytoplasm of cells during the lytic phase. we also found that ... | 2015 | 26057150 |
| epstein-barr virus latent membrane protein 2a mediated activation of sonic hedgehog pathway induces hla class ia downregulation in gastric cancer cells. | one of the immune evasion strategies manifested by malignant cells is the downregulation of the human leukocyte antigen (hla). hla class i (hla- a, -b, -c) present endogenous peptides including viral and tumor antigens to cytotoxic t lymphocytes for immune mediated destruction. we have found the epstein barr virus (ebv) latent membrane protein 2a (lmp2a) to be responsible for this hla downregulation in gastric cancer cells. our results further indicate the sonic hedgehog pathway; primarily gli1 ... | 2015 | 26057149 |
| cox-2 induces lytic reactivation of ebv through pge2 by modulating the ep receptor signaling pathway. | inflammation is one of the predisposing factors known to be associated with epstein barr virus (ebv) mediated tumorigenesis. however it is not well understood whether inflammation in itself plays a role in regulating the life cycle of this infectious agent. cox-2, a key mediator of the inflammatory processes is frequently over-expressed in ebv positive cancer cells. in various tumors, pge2 is the principle cox-2 regulated downstream product which exerts its effects on cellular processes through ... | 2015 | 26057147 |
| cytotoxic molecule-positive epstein-barr virus-associated peripheral t-cell lymphoma in a 20-month-old child: a case report and review of the literature. | peripheral t-cell lymphoma (ptcl) is rare in children. expression of cytotoxic molecules (cm) in nodal ptcl has unique clinicopathologic features, including an epstein-barr virus (ebv) association. however, cm+, ebv-associated ptcl is extremely rare in the childhood, with only 1 study having been reported to date, including both pediatric and adult patients. we report a case of cm+ ptcl in a 20-month-old boy with left neck lymphadenopathy as well as multiple visceral lesions. a biopsied lymph no ... | 2015 | 26056791 |
| atypical clinical course in pediatric hodgkin lymphoma: association with germline mutations in interleukin-2-inducible t-cell kinase. | inherited or acquired immune dysregulation is associated with increased risk of lymphoproliferative disorders (lpds), including classic hodgkin lymphoma (chl). a germline mutation in interleukin-2-inducible t-cell kinase (itk) is described in individuals manifesting b-cell lpds, chl, and hemophagocytic syndromes following epstein-barr virus (ebv) infection. | 2015 | 26056787 |
| stage, age, and ebv status impact outcomes of plasmablastic lymphoma patients: a clinicopathologic analysis of 61 patients. | plasmablastic lymphoma (pbl) is a rare aggressive neoplasm with lymphoid and plasmacytic differentiation that is commonly associated with immunodeficiency and an unfavorable prognosis. clinicopathologic features have been largely derived from cases reports and small series with limited outcome analyses. | 2015 | 26055271 |
| diffuse large b-cell lymphoma of the gingiva in a patient on long-term use of methotrexate being treated for psoriasis. | an 81-year-old male patient presented with a large gingival ulcer of 2 months' duration. he had been taking methotrexate, a potent anti-inflammatory/immunosuppressant, for the past 50 years to treat psoriasis. a biopsy revealed diffuse large b-cell lymphoma epstein-barr virus positive. remission occurred after discontinuing the medication. clinicians noting a non-healing ulcer in the mucosal or keratinized tissue of the oral cavity of a patient on immunosuppressants should perform a biopsy exami ... | 2015 | 26053781 |
| candidate gene association studies and risk of hodgkin lymphoma: a systematic review and meta-analysis. | to evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to hodgkin lymphoma (hl), we conducted a systematic review and meta-analysis of published case-control studies. of the variants examined more than once in candidate gene association studies, we identified 21 studies that reported on 12 polymorphic variants in 10 genes. data were also extracted from a published genome wide association study to allow analysis of an additional 47 variants in a ... | 2017 | 26053036 |
| the seroprevalence and salivary shedding of herpesviruses in behçet's syndrome and recurrent aphthous stomatitis. | behçet's syndrome (bs) is one of the multisystemic diseases that presents with oral ulceration and several other systemic manifestations including genital ulceration, folliculitis, erythema nodosum-like lesions, uveitis, and arthropathy. ocular manifestation, central nervous system involvement, and gastrointestinal manifestation account for most of the complications of this disease, whereas orogenital ulceration and dermatological involvement affects the quality of life. the cause of the disease ... | 2015 | 26051327 |
| protection from varicella zoster in solid organ transplant recipients carrying killer cell immunoglobulin-like receptor b haplotypes. | natural killer cell function is regulated by inhibitory and activating killer cell immunoglobulin-like receptors (kir). previous studies have documented associations of kir genotype with the risk of cytomegalovirus (cmv) replication after solid organ transplantation. | 2015 | 26050016 |
| recovery of a human natural antibody against the noncollagenous-1 domain of type iv collagen using humanized models. | anti-glomerular basement membrane nephritis and goodpasture syndrome result from autoantibody (ab)-mediated destruction of kidney and lung. ab target the noncollagenous 1 (nc1) domain of alpha3(iv) collagen, but little is known about ab origins or structure. this ignorance is due in part to the inability to recover monoclonal ab by transformation of patients' blood cells. the aim of this study was to assess the suitability of two humanized models for this purpose. | 2015 | 26048777 |
| epstein-barr virus-associated pulmonary smooth muscle tumor after lung transplantation. | we report an epstein-barr virus (ebv)-associated pulmonary posttransplant smooth muscle tumor arising in the left lung of a 71-year-old bilateral lung transplant recipient nearly 3 years after transplantation, treated with thoracoscopic wedge resection. four previous smooth muscle tumors have been reported following lung transplantation. to our knowledge, this is the first reported case of an ebv-positive posttransplant smooth muscle tumor within the transplanted lung. we describe the clinical, ... | 2015 | 26046906 |
| printed flexible plastic microchip for viral load measurement through quantitative detection of viruses in plasma and saliva. | we report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. point-of-care (poc) viral load measurement is of paramount importance with significant impact on a broad range of applications, including infectious disease diagnostics and treatment monitoring specifically in resource-constrained settings. here, we present a broadly applicable and inexpensive biosensing technology for accurate quantification o ... | 2015 | 26046668 |
| multiple sclerosis and environmental factors: the role of vitamin d, parasites, and epstein-barr virus infection. | pathogenic mechanisms underlying multiple sclerosis development have yet to be clearly identified, but considerable evidence indicates that autoimmunity plays an important role in the etiology of the disease. it is generally accepted that autoimmune diseases like ms arise from complex interactions between genetic susceptibility and environmental factors. although environmental factors unequivocally influencing ms development have yet to be established, accumulating evidence singles out several c ... | 2015 | 26046559 |
| broad spectrum antiviral t cells for viral complications after hematopoietic stem cell transplantation. | major complications of hematopoietic stem cell transplantation (hsct) or solid organ transplantation (sot), such as graft rejection and graft-versus-host-disease (gvhd), are countered by suppressing the host immune system via chemotherapy and radiation, immunosuppressive drugs, or conditioning regimens such as in vivo or in vitro t-cell depletion. while immunocompromised, the patient is rendered susceptible to a number of viral infections and reactivations mainly caused by endogenous herpes viru ... | 2015 | 26046087 |
| epstein-barr virus-associated lymphoepithelial carcinoma of the larynx. | lymphoepithelial carcinoma is a rare tumour, named after its histological resemblance to undifferentiated nasopharyngeal carcinoma. the pathogenesis of lymphoepithelial carcinoma remains unknown. this tumour has been described in several organs, but the larynx remains an exceptional site. | 2015 | 26043818 |
| intrathecal cd8 t-cells of multiple sclerosis patients recognize lytic epstein-barr virus proteins. | the association between epstein-barr virus (ebv) and multiple sclerosis (ms) may involve intrathecal ebv-specific t-cell responses targeting the virus or indirectly, autoantigens. | 2016 | 26041797 |
| correction: epstein-barr virus genetic variation in lymphoblastoid cell lines derived from kenyan pediatric population. | 2015 | 26039342 | |
| understanding the interplay between host immunity and epstein-barr virus in npc patients. | epstein-barr virus (ebv) has been used as a paradigm for studying host-virus interactions, not only because of its importance as a human oncogenic virus associated with several malignancies including nasopharyngeal carcinoma (npc) but also owing to its sophisticated strategies to subvert the host antiviral responses. an understanding of the interplay between ebv and npc is critical for the development of ebv-targeted immunotherapy. here, we summarize the current knowledge regarding the host immu ... | 2015 | 26038769 |
| oncogenes and rna splicing of human tumor viruses. | approximately 10.8% of human cancers are associated with infection by an oncogenic virus. these viruses include human papillomavirus (hpv), epstein-barr virus (ebv), merkel cell polyomavirus (mcv), human t-cell leukemia virus 1 (htlv-1), kaposi's sarcoma-associated herpesvirus (kshv), hepatitis c virus (hcv) and hepatitis b virus (hbv). these oncogenic viruses, with the exception of hcv, require the host rna splicing machinery in order to exercise their oncogenic activities, a strategy that allo ... | 2014 | 26038756 |
| the association between infectious burden and parkinson's disease: a case-control study. | the etiology of parkinson's disease (pd) remains unclear. the aim of this study was to examine the association between common pathogenic infections and pd. | 2015 | 26037459 |
| human adenoviruses role in ophthalmic pterygium formation. | ophthalmic pterygium is a common benign lesion of unknown origin and the pathogenesis might be vision-threatening. this problem is often associated with exposure to solar light. recent evidence suggests that potentially oncogenic viruses such as human papillomavirus and epstein-barr virus may be involved in the pathogenesis of pterygia. expression of specific adenovirus genes such as e1a and e1b, which potentially have many functions, may contribute to their oncogenic activity as well as relevan ... | 2015 | 26034543 |
| the incidence of epstein-barr virus primary infection among suspected patients referred to namazi hospital of shiraz, iran. | many children become infected with epstein-barr virus (ebv) during their childhood. since the clinical profile of ebv primary infection is challenging, it is important to use the best diagnostic clinical means. detection of igm against viral capsid antigen (vca) by elisa has been shown to be a reliable method. | 2015 | 26034534 |
| interleukin 35 is an independent prognostic factor and a therapeutic target for nasopharyngeal carcinoma. | interleukin (il)-35 is composed of two subunits: epstein-barr virus-induced gene 3 (ebi3) and il-12p35. recently, overexpression of il-35 has been found in several types of cancers. however, its clinical significance in nasopharyngeal carcinoma is still obscure. we have studied the clinical significance of il-35 expression and its correlation with outcome of nasopharyngeal carcinoma patients. | 2015 | 26034389 |
| [acute herpesviridae hepatitis during pregnancy: a review]. | viral hepatitis are well defined during pregnancy, including hepatitis a, b, c, d or e. in contrast, viral hepatitis called non-alphabetic, like viruses herpesviridae family hepatitis [cytomegalovirus (cmv), varicella-zoster virus (vzv), epstein-barr virus (ebv) or herpes simplex virus (hsv)] are rarely described. the aim of this article is to make a focus on the care of these viral herpesviridae hepatitis during pregnancy. herpes hepatitis is more common during pregnancy, with a neonatal risk a ... | 2015 | 26033557 |
| association between human papillomavirus and epstein - barr virus dna and gene promoter methylation of rb1 and cdh1 in the cervical lesions: a transversal study. | human papillomavirus (hpv) inactivates the retinoblastoma 1 (rb1) gene by promoter methylation and reduces cellular e-cadherin expression by overexpression of dna methyltransferase 1 (dnmt1). the epstein-barr virus (ebv) is an oncogenic virus that may be related to cervical carcinogenesis. in gastric cancer, it has been demonstrated that e-cadherin gene (cdh1) hypermethylation is associated with dnmt1 overexpression by ebv infection. our aim was to analyze the gene promoter methylation frequency ... | 2015 | 26032781 |
| an adult case of systemic epstein-barr virus-positive t-cell lymphoproliferative disorder with severe hepatic dysfunction and megalosplenia. | epstein-barr virus-positive t/nk-cell lymphoproliferative disorder (ebv+t/nk-lpd) is a continuous spectrum of diseases that share a common feature observed in t cells and nk cells: excessive lymphoid proliferation. this disease is rare in adults and predominantly affects children with high mortality. herein, we present a case of ebv+t-lpd that occurred in an adult with clinical manifestations of hepatic dysfunction and megalosplenia. the patient received a splenectomy at a local hospital for the ... | 2015 | 26031871 |
| a suspected case of plasma cell-rich acute renal transplant rejection associated with de novo donor-specific antibody. | a kidney transplant case with de novo donor-specific antibody showed monoclonal plasma cell infiltration into the graft with abo incompatibility. three years after transplantation, the patient's graft function suddenly deteriorated. interstitial edema and the predominant infiltration of inflammatory plasma cells with kappa chain monoclonality were observed in biopsy specimens. the in situ hybridization of epstein-barr virus was negative and post-transplant lymphoproliferative disorder was not ev ... | 2015 | 26031590 |
| [the laboratory diagnostic of herpes viral infections under nosocomial pneumonia in oncologic hematologic patients]. | the study was organized to discover diagnostically valuable clinical material for detection of etiologic agent of pneumonia in oncological hematological patients, rate of association of nosocomial pneumonia with herpes viruses and evaluation of viral load in patients with depressed immunity. in oncological hematological patients, half of nosocomial pneumonia cases is associated with herpes virus. in every third patient dna of epstein-barr virus and dna of type i and ii are detected. the most inf ... | 2015 | 26031167 |
| cerebral lymphoma in a kidney transplant: a case report. | posttransplant lymphoproliferative disorder is a serious complication during a solid-organ transplant. a 28-year-old asiatic man developed a cerebral lesion that was considered an abscess, while undergoing a kidney transplant. the lesion diameter did not go down with antibiotic therapy, so he underwent a complete surgical mass excision. pathology showed a b-cell lymphoma. the epstein-barr virus-dna by polymerase chain reaction in plasma was negative. he began chemotherapy with methotrexate and r ... | 2015 | 26030159 |
| anterior opercular syndrome induced by epstein-barr virus encephalitis. | we report a 19-year-old female presenting with fever, drooling, anarthria, and voluntary facial movement disruption, characteristic of anterior opercular syndrome (aos). serological examination revealed epstein-barr virus (ebv) infection following acute encephalitis with severe ataxia. a single-photon emission computerized tomography (spect) examination indicated hypoperfusion in the left perisylvian region, bilateral thalamus, occipital lobe, and cerebellum. this is the first report of aos rela ... | 2016 | 26027635 |
| the ebna-2 n-terminal transactivation domain folds into a dimeric structure required for target gene activation. | epstein-barr virus (ebv) is a γ-herpesvirus that may cause infectious mononucleosis in young adults. in addition, epidemiological and molecular evidence links ebv to the pathogenesis of lymphoid and epithelial malignancies. ebv has the unique ability to transform resting b cells into permanently proliferating, latently infected lymphoblastoid cell lines. epstein-barr virus nuclear antigen 2 (ebna-2) is a key regulator of viral and cellular gene expression for this transformation process. the n-t ... | 2015 | 26024477 |
| epstein barr virus-positive mucocutaneous ulcer of the colon associated hodgkin lymphoma in crohn's disease. | epstein barr virus (ebv) positive mucocutaneous ulcers (ebvmcu) form part of a spectrum of ebv-associated lymphoproliferative disease. they have been reported in the setting of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin and gastrointestinal tract (git). case reports and series to date suggest a benign natural history responding to conservative management, particularly in the git. we report an unusual case of ebvmcu in the colon, arising in the set ... | 2015 | 26019475 |
| cross talk between ebv and telomerase: the role of tert and notch2 in the switch of latent/lytic cycle of the virus. | epstein-barr virus (ebv)-associated malignancies, as well as lymphoblastoid cell lines (lcls), obtained in vitro by ebv infection of b cells, express latent viral proteins and maintain their ability to grow indefinitely through inappropriate activation of telomere-specific reverse transcriptase (tert), the catalytic component of telomerase. our previous studies demonstrated that high levels of tert expression in lcls prevent the activation of ebv lytic cycle, which is instead triggered by tert s ... | 2015 | 26018735 |
| epstein-barr virus-related post-transplant lymphoproliferative disorder in the skin. | 2015 | 26017499 | |
| long-term outcome of extranodal nk/t cell lymphoma patients treated with postremission therapy using ebv lmp1 and lmp2a-specific ctls. | extranodal nk/t-cell lymphoma (enktcl) is associated with latent epstein-barr virus (ebv) infection and frequent relapse even after complete response (cr) to intensive chemotherapy and radiotherapy. the expression of ebv proteins in the tumor provides targets for adoptive immunotherapy with antigen-specific cytotoxic t cells (ctl). to evaluate the efficacy and safety of ebv latent membrane protein (lmp)-1 and lmp-2a-specific ctls (lmp1/2a ctls) stimulated with lmp1/2a rna-transferred dendritic c ... | 2015 | 26017177 |
| integrated genomic analysis suggests mll3 is a novel candidate susceptibility gene for familial nasopharyngeal carcinoma. | little is known about genetic factors associated with nasopharyngeal carcinoma (npc). to gain insight into npc etiology, we performed whole exome sequencing on germline and tumor dna from three closely related family members with npc. | 2015 | 26014803 |
| [expression of cd163 in children with epstein-barr virus infection]. | to study the clinical significance of cd163 in the diagnosis and the evaluation of severity and prognosis of childhood hemophagocytic lymphohistiocytosis (hlh). | 2015 | 26014702 |
| treating burkitt lymphoma in adults. | burkitt lymphoma is an uncommon form of aggressive lymphoma affecting approximately 1200 patients per year in the usa. it is characterized by a translocation involving the myc oncogene. three subtypes of burkitt lymphoma are recognized: the endemic form, occurring primarily in africa and associated with the epstein-barr virus (ebv); the sporadic form, representing less than 3 % of all non-hodgkin lymphomas (nhl); and the immunodeficiency-associated form, occurring primarily in hiv-infected patie ... | 2015 | 26013028 |
| [infections during the first posttransplant year--experience at sibenik general hospital]. | the aim of this study was to assess the frequency and type of infective complications in kidney recipients during the first year after transplantation. | 2014 | 26012149 |
| interaction of human tumor viruses with host cell surface receptors and cell entry. | currently, seven viruses, namely epstein-barr virus (ebv), kaposi's sarcoma-associated herpes virus (kshv), high-risk human papillomaviruses (hpvs), merkel cell polyomavirus (mcpyv), hepatitis b virus (hbv), hepatitis c virus (hcv) and human t cell lymphotropic virus type 1 (htlv-1), have been described to be consistently associated with different types of human cancer. these oncogenic viruses belong to distinct viral families, display diverse cell tropism and cause different malignancies. a key ... | 2015 | 26008702 |
| genotypic analysis and latent membrane protein 1 expression of epstein-barr virus in extranodal nk/t-cell lymphoma from northern chinese patients. | as the most common nk/t-cell lymphoma in asian countries, extranodal nk/t-cell lymphoma, nasal type (enktl), has unique clinical features and a strong association with epstein-barr virus (ebv). in order to gain a preliminary understanding of the relationship between enktl and ebv, we performed genotypic analysis of ebv and investigated lmp1 expression in extranodal nk/t-cell lymphoma. our study shows that enktl is an ebv-associated malignancy and that a, c and f are the predominant ebv genotypes ... | 2015 | 26008210 |
| acute mediastinitis as a complication of epstein-barr virus. | acute mediastinitis is a rare, potentially life-threatening condition that is most commonly seen as a complication of esophageal perforations or cardiac surgery. the term "descending necrotizing mediastinitis" (dnm) is used to describe oropharyngeal infections that spread to the mediastinum, most commonly following odontogenic infections, peritonsillar or retropharyngeal abscesses, cervical lymphadenitis, trauma, or endotracheal intubation. infectious mononucleosis is another rare cause of dnm. ... | 2016 | 26007626 |
| epstein-barr virus bzlf1 protein impairs accumulation of host dna damage proteins at damage sites in response to dna damage. | epstein-barr virus (ebv) infection is closely associated with several human malignancies including nasopharyngeal carcinoma (npc). the ebv immediate-early protein bzlf1 is the key mediator that switches ebv infection from latent to lytic forms. the lytic form of ebv infection has been implicated in human carcinogenesis but its molecular mechanisms remain unclear. bzlf1 has been shown to be a binding partner of several dna damage response (ddr) proteins. its functions in host ddr remain unknown. ... | 2015 | 26006018 |
| programmed death-1 (pd-1), programmed death-ligand 1 (pd-l1), and ebv-encoded rna (eber) expression in hodgkin lymphoma. | programmed death-1 (pd-1) and programmed death-ligand 1 (pd-l1) are new targets in cancer immunotherapy. pd-1 protein is an immune checkpoint expressed in many tumors. epstein-barr virus (ebv) is present in malignant hodgkin/reed-sternberg (hrs) cells in approximately 40-50 % of hodgkin lymphoma (hl). the aim of this study is to evaluate the clinical and prognostic importance of pd-1 and/or pd-l1 in hl and also to determine the association between ebv-encoded rna (eber) and pd-1/pd-l1. formalin- ... | 2015 | 26004934 |
| evidence for a vascular microbiome and its role in vessel health and disease. | we have summarized available evidence for and against the presence of a vascular microbiome. studies that have attempted to detect bacteria and viruses in blood vessels in both health and disease are critiqued in an attempt to explain contrary results that may be due to variations in methodology. | 2015 | 26002032 |
| isotypes of epstein-barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies. | in order to study the humoral immune response against epstein-barr virus (ebv) in patients with rheumatoid arthritis (ra) and to compare it with the two major autoantibody types in ra, plasma samples from 77 ra patients, 28 patients with systemic lupus erythematosus (sle), and 28 healthy controls (hcs) were investigated by enzyme-linked immunosorbent assays (elisa). increased percentages of positives and concentrations of igg/iga/igm antibodies against the latent ebv nuclear antigen-1 (ebna-1) w ... | 2015 | 26000294 |
| ebv-positive large b-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment. | few studies have reported epstein-barr virus-positive (ebv(+)) large b-cell lymphomas (lbcls) in young patients without immunodeficiency. we identified 46 such cases in patients ≤45 years of age and analyzed the clinical and pathological characteristics. ebv(+) lbcls affected predominantly males (male:female = 3.6:1), with a median age of 23 years (range, 4-45 years). all patients presented with lymphadenopathy and 11% also had extranodal disease. morphologically, 3 patterns were identified: t-c ... | 2015 | 25999451 |
| the clinical utility of plasma epstein-barr virus dna assays in nasopharyngeal carcinoma: the dawn of a new era?: a systematic review and meta-analysis of 7836 cases. | in this study, we assessed the potential of plasma epstein-barr virus (ebv) dna assays to predict clinical outcomes in a large sample of nasopharyngeal carcinoma (npc) patients and proposed a risk stratification model based on standardized ebv dna load monitoring.we conducted a meta-analysis of 14 prospective and retrospective comparative studies (n = 7 836 patients) to evaluate the correlation between pretreatment plasma ebv dna (pre-dna), midtreatment plasma ebv dna (mid-dna), posttreatment pl ... | 2015 | 25997061 |
| epstein-barr virus infection and gastric cancer: a systematic review. | epstein-barr virus (ebv) infection is found in a subset of gastric cancers. previous reviews have exclusively focused on ebv-encoded small rna (eber) positivity in gastric cancer tissues, but a comprehensive evaluation of other type of studies is lacking.we searched the pubmed database up to september, 2014, and performed a systematic review.we considered studies comparing ebv nucleic acids positivity in gastric cancer tissue with positivity in either adjacent non-tumor tissue of cancer patients ... | 2015 | 25997049 |
| traf1 coordinates polyubiquitin signaling to enhance epstein-barr virus lmp1-mediated growth and survival pathway activation. | the epstein-barr virus (ebv) encoded oncoprotein latent membrane protein 1 (lmp1) signals through two c-terminal tail domains to drive cell growth, survival and transformation. the lmp1 membrane-proximal tes1/ctar1 domain recruits trafs to activate map kinase, non-canonical and canonical nf-kb pathways, and is critical for ebv-mediated b-cell transformation. traf1 is amongst the most highly tes1-induced target genes and is abundantly expressed in ebv-associated lymphoproliferative disorders. we ... | 2015 | 25996949 |
| gammaherpesvirus co-infection with malaria suppresses anti-parasitic humoral immunity. | immunity to non-cerebral severe malaria is estimated to occur within 1-2 infections in areas of endemic transmission for plasmodium falciparum. yet, nearly 20% of infected children die annually as a result of severe malaria. multiple risk factors are postulated to exacerbate malarial disease, one being co-infections with other pathogens. children living in sub-saharan africa are seropositive for epstein barr virus (ebv) by the age of 6 months. this timing overlaps with the waning of protective m ... | 2015 | 25996913 |
| spontaneous post-transplant disorders in nod.cg- prkdcscid il2rgtm1sug/jictac (nog) mice engrafted with patient-derived metastatic melanomas. | patient-derived tumor xenograft (pdtx) approach is nowadays considered a reliable preclinical model to study in vivo cancer biology and therapeutic response. nod scid and il2rg-deficient mice represent the "gold standard" host for the generation of pdtxs. compared to other immunocompromised murine lines, these mice offers several advantages including higher engraftment rate, longer lifespan and improved morphological and molecular preservation of patient-derived neoplasms. here we describe a spe ... | 2015 | 25996609 |
| case–control study of epstein–barr virus and helicobacter pylori serology in latin american patients with gastric disease. | chronic tissue damage induced by helicobacter pylori (hp)-driven inflammation is considered the main risk of gastric carcinoma (gc). epstein–barr virus (ebv) infection has also been associated with gc. in this study, we aim to address the role of ebv in inflammatory gc precursor lesions and its added risk to hp infection. | 2015 | 25996206 |
| primary hepatic leiomyoma: unusual cause of an intrahepatic mass. | leiomyomas are benign lesions arising from the smooth muscle layer. they are most commonly detected either within the gastrointestinal or genitourinary tracts. primary hepatic leiomyoma (phl) is a rare pathology. it is an isolated pathology within the liver, without evidence of any other coexisting leiomyomas. very few cases have been described in literature. phl may occur in healthy individuals although an association with immunodeficiency and epstein-barr virus (ebv) infection has been observe ... | 2015 | 25992372 |
| impact of the environment on multiple sclerosis. | epidemiological studies suggest that environmental factors play a significant role in the development of multiple sclerosis. this article presents current knowledge on the impact of the environment on disease risk and disease course. | 2015 | 25991624 |
| autoantibody signatures combined with epstein-barr virus capsid antigen-iga as a biomarker panel for the detection of nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is prevalent in southern china and southeast asia, and autoantibody signatures may improve early detection of npc. in this study, serum levels of autoantibodies against a panel of six tumor-associated antigens (p53, ny-eso-1, mmp-7, hsp70, prx vi, and bmi-1) and epstein-barr virus capsid antigen-iga (vca-iga) were tested by enzyme-linked immunosorbent assay in a training set (220 npc patients and 150 controls) and validated in a validation set (90 npc patients and ... | 2015 | 25990085 |
| basophil activation by mosquito extracts in patients with hypersensitivity to mosquito bites. | hypersensitivity to mosquito bites (hmb) is a cutaneous disorder belonging to the group of epstein-barr virus (ebv)-associated t/natural killer (nk)-cell lymphoproliferative diseases, and is primarily mediated by ebv-infected nk cells. it is characterized by intense local skin reactions accompanied by general symptoms after mosquito bites, and infiltration of ebv-infected nk cells into the bite sites. however, the mechanisms underlying these reactions have not been fully examined. we recently de ... | 2015 | 25990049 |
| hemophagocytic syndrome complicating cardiac transplantation. | infection-associated hemophagocytic syndrome is one of the hemophagocytic disorders, and is most often seen in the pediatric population, typically in the setting of immunosuppression. we present the case of a 33-year-old man who had been well for more than 3 years following cardiac transplantation until he developed the infection-associated hemophagocytic syndrome. the patient had a fulminant downhill course, dying in shock 10 weeks after his first presentation. serologic studies for epstein-bar ... | 2015 | 25989963 |
| hepatoid carcinoma of the pancreas with lymphoid stroma: first description of the clinical, morphological, immunohistochemical, and molecular characteristics of an unusual pancreatic carcinoma. | we report a case of tumour in the head of the pancreas observed in a 57-year-old man with a history of worsening jaundice and elevated alpha-fetoprotein (afp) serum level, who underwent whipple pancreatoduodenectomy. histologically, the tumour was predominantly composed of solid sheets of large eosinophilic cells with a prominent lymphoid infiltration without association neither with dna microsatellite instability nor epstein-barr virus infection. the tumour was diffusely and strongly positive f ... | 2015 | 25989715 |
| rapamycin ameliorates the ctla4-ig-mediated defect in cd8(+) t cell immunity during gammaherpesvirus infection. | latent viral infections are a major concern among immunosuppressed transplant patients. during clinical trials with belatacept, a ctla4-ig fusion protein, patients showed an increased risk of epstein-barr virus-associated posttransplant lymphoproliferative disorder, thought to be due to a deficient primary cd8(+) t cell response to the virus. using a murine model of latent viral infection, we observed that rapamycin treatment alone led to a significant increase in virus-specific cd8(+) t cells, ... | 2015 | 25989700 |
| clinicopathological findings of chronic rejection in a face grafted patient. | skin chronic rejection (cr) in vascularized composite allotransplantation has not been included in the banff classification yet. we report a face-transplant patient who developed cutaneous clinicopathologic changes suggestive of cr. | 2015 | 25989498 |
| the impact of ebv status on characteristics and outcomes of posttransplantation lymphoproliferative disorder. | we examined the associations of epstein-barr virus (ebv) status with characteristics and outcomes of posttransplantation lymphoproliferative disorder (ptld) by studying 176 adult solid organ transplant recipients diagnosed with ptld between 1990 and 2013 (58 [33%] ebv-negative; 118 [67%] ebv-positive). the proportion of ebv-negative cases increased over time from 10% (1990-1995) to 48% (2008-2013) (p < 0.001). ebv-negative ptld had distinct characteristics (monomorphic histology, longer latency) ... | 2015 | 25988622 |
| severe leptospirosis complicated by epstein-barr virus reactivation. | weil's disease is a severe, potentially fatal illness following leptospira interrogans infection. the reported case of a patient suffering from acute renal failure, jaundice, thrombocytopenia, rhabdomyolysis and encephalitis syndrome highlights the clinical challenge in reference to weil syndrome complicated by epstein-barr virus (ebv) reactivation. | 2015 | 25987479 |
| breast milk as a potential source of epstein-barr virus transmission among infants living in a malaria-endemic region of kenya. | we previously reported that infants in kenya were infected with epstein-barr virus (ebv) at <6 months of age, suggesting that mothers were the likely source of transmissible virus to the infant. in this study, we investigated whether breast milk contained infectious ebv and the role of malaria in ebv shedding in breast milk. | 2015 | 25985902 |
| tissue is the issue: a solitary cerebral lesion 15 years after kidney transplantation. | primary toxoplasmosis and reactivation of latent infections occur in solid organ transplant recipients. however, solitary cerebral lesions due to toxoplasmosis are rare. in this case, a patient presented with a haemiparesis and a cerebral lesion. we expected to find cerebral post-transplant lymfoproliferative disorder because of positive epstein-barr virus by polymerase chain reaction in cerebrospinal fluid, but histological findings revealed toxoplasma gondii bradyzoites and tachyzoites, illust ... | 2011 | 25984209 |
| a case of mononucleosis infectiosa presenting with cholemic nephrosis. | a 38-year-old male was admitted with fever, progressive jaundice, cervical lymphadenopathy, hepatomegaly and acute oliguric renal failure. epstein-barr virus (ebv) infection was diagnosed by detection of ebv-dna in plasma and confirmed by ebv seroconversion. kidney biopsy revealed acute tubular necrosis and abundant casts, consisting of bilirubin pigment. with conservative treatment, the patient fully recovered from cholemic nephrosis, an uncommon condition, not described after ebv infection bef ... | 2011 | 25984148 |
| epstein-barr virus-associated gastric carcinoma 33 years after kidney transplantation. | epstein-barr virus-associated gastric carcinoma (ebvagc) is a unique type of gastric cancer, defined as the presence of ebv in gastric tumour cells, usually identified by in situ hybridization. a poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. neoplastic epithelial cells were ebv positive by in situ hybridization. gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes ... | 2011 | 25984103 |
| membranoproliferative glomerulonephritis associated with an epstein-barr virus infection. | type 1 membranoproliferative glomerulonephritis (mpgn) is an immune complex-mediated disorder that has been associated with certain viral infections including hepatitis c, hepatitis b, hepatitis g, hiv and hantavirus. we describe a patient with type 1 mpgn in native kidneys and nephrotic syndrome in whom there was strong evidence that a primary epstein-barr virus (ebv) infection played a causative role. this patient was treated with an angiotensin 2-receptor blocker and the nephrotic syndrome re ... | 2008 | 25983923 |
| lymphomatoid granulomatosis with spinal involvement after childhood acute lymphoblastic leukemia. | lymphomatoid granulomatosis (lyg) is a lymphoproliferative disease involving the lungs most frequently; however, it may also involve the kidneys, skin and especially the central nervous system. unique initial presentation of spinal involvement is extremely rare and epidural lesion of thoracic spine has not been reported. the prognosis for lyg has been reported to be poor, and there currently exists no satisfactory established treatment protocol. the purpose of this study is to report a case of s ... | 2012 | 25983786 |
| human gammaherpesviruses viraemia in hiv infected patients. | the epstein-barr virus (ebv) and kaposi's sarcoma associated herpesvirus (kshv) are consistently associated with lymphoproliferative diseases and cancers in humans, notably in patients with hiv. | 2015 | 25979989 |
| multiple sclerosis. | multiple sclerosis (ms) is a chronic, debilitating disease that can have devastating effects. presentation varies widely in symptoms, pace, and progression. in addition to a thorough history and physical examination, diagnostic tools required to diagnose ms and exclude other diagnoses include mri, evoked potential testing, and cerebrospinal fluid analysis. although the disease is not curable presently, quality of life can be improved by minimizing the frequency and severity of disease burden. di ... | 2015 | 25979578 |
| nasopharyngeal carcinoma. | nasopharyngeal carcinoma is uncommon in the united states, with only 0.2 to 0.5 cases per 100,00 people; this is in contrast to southern china and hong kong, where the incidence is 25 to 50 per 100,000 people. there is a potential link between epstein-barr virus and the development of nasopharyngeal carcinoma. radiotherapy alone as a single modality leads to similar 10-year survival rates in united states, denmark, and hong kong (34%, 37%, and 43%, respectively). multiple studies have shown an a ... | 2015 | 25979399 |
| evidence for viral infection as a causative factor of human biliary atresia. | to explore the evidence for viral infections triggering human biliary atresia (ba) by reviewing archival original articles that analyzed human samples via polymerase chain reaction (pcr) experiments, considering the recent experimental trend of extensive use of rotaviral ba animal models. | 2015 | 25979202 |
| development of a time-resolved fluoroimmunoassay for epstein-barr virus viral capsid antigen iga antibody in human serum. | viral capsid antigen (vca) iga is one of the most commonly tested antibodies for epstein-barr virus (ebv) in the clinic and is a proven biomarker to predict the risk of nasopharyngeal carcinoma (npc) and other diseases. at present, a vca-iga antibody is used for clinical diagnosis by enzyme-linked immunosorbent assay (elisa), which can detect samples only qualitatively or semi-quantitatively, with unsatisfactory sensitivity and specificity. in this study, an indirect time-resolved fluoroimmunoas ... | 2015 | 25977184 |