Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine. | the base moiety of the potent antiherpetic agent 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine 3 was transformed into that of the tricyclic 3,9-dihydro-9-oxo-6-r-5h-imidazo[1,2-a]purine system. the tricyclic analogues 5a-d were evaluated for their activity against herpes viruses as well as for cytostatic activity against hsv-1 thymidine kinase (tk) gene-transduced human osteosarcoma tumor cells. marked activity was found against vzv. the 6-phenyl-substituted fluorescent analogue ... | 2006 | 16458009 |
| real-time pcr quantification of genital shedding of herpes simplex virus (hsv) and human immunodeficiency virus (hiv) in women coinfected with hsv and hiv. | the accuracy and usefulness of laboratory-developed real-time pcr procedures using a light cycler instrument (roche diagnostics) for detecting and quantifying human immunodeficiency virus type 1 (hiv-1) rna and dna as well as herpes simplex virus type 1 (hsv-1)/hsv-2 dna in cervicovaginal secretions from women coinfected with hiv and hsv were evaluated. for hiv-1, the use of the nec152 and nec131 primer set and the nec-ltr probe in the long terminal repeat gene allowed us to detect accurately th ... | 2006 | 16455895 |
| quantitative comparison of the hsv-1 and hsv-2 transcriptomes using dna microarray analysis. | the genomes of human herpes virus type-1 and type-2 share a high degree of sequence identity; yet, they exhibit important differences in pathology in their natural human host as well as in animal host and cell cultures. here, we report the comparative analysis of the time and relative abundance profiles of the transcription of each virus type (their transcriptomes) using parallel infections and microarray analysis using hsv-1 probes which hybridize with high efficiency to orthologous hsv-2 trans ... | 2006 | 16448680 |
| prevalence and persistence of antibodies to herpes viruses, chlamydia pneumoniae and helicobacter pylori in alaskan eskimos: the gocadan study. | the prevalence and persistence of antibodies against cytomegalovirus (cmv), herpes simplex virus types 1 (hsv1) and 2 (hsv2), helicobacter pylori and chlamydia pneumoniae were determined in alaskan eskimos. the study included 610 individuals (mean age 43 +/- 15 years; 45% males) participating in the genetics of coronary artery disease in alaska natives (gocadan) study. archived serum samples and those collected during the gocadan study were analysed for antibodies against the above pathogens by ... | 2006 | 16441448 |
| simple synthesis and anti-hiv activity of novel cyclopentene phosphonate nucleosides. | a very simple synthetic route for novel cyclopentene phosphonate nucleosides is described. the characteristic cyclopentene moiety 6 was constructed via a ring-closing metathesis of divinyl 5, which could be readily prepared from diethylmalonate. the condensation of the mesylate 11 with nucleobases (a, c, t, u) under nucleophilic substitution conditions (k2co3, 18-crown-6, dmf) afforded the target nucleosides 12, 13, 14, and 15. in addition, the antiviral evaluations against various viruses were ... | 2006 | 16440980 |
| phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. | the z- and e-thymine and cytosine pronucleotides 3d, 4d, 3e, and 4e of methylenecyclopropane nucleosides analogues were synthesized, evaluated for their antiviral activity against human cytomegalovirus (hcmv), herpes simplex virus 1 and 2 (hsv-1 and hsv-2), varicella zoster virus (vzv), epstein-barr virus (ebv), human immunodeficiency virus type 1 (hsv-1), and hepatitis b virus (hbv) and their potency was compared with the parent compounds 1d, 2d, 1e, and 2e. prodrugs 3d and 4d were obtained by ... | 2005 | 16438046 |
| ent-epiafzelechin-(4alpha-->8)-epiafzelechin extracted from cassia javanica inhibits herpes simplex virus type 2 replication. | herpes simplex virus (hsv) is a ubiquitous organism that causes infections in human populations throughout the world. it causes a variety of diseases ranging in severity from mild to life-threatening. in this study, ent-epiafzelechin-(4alpha-->8)-epiafzelechin (eee) extracted from the fresh leaves of cassia javanica l. agnes de wit (leguminosae) was investigated for its in vitro anti-hsv-2 activity using xtt and plaque reduction assays. results showed that eee inhibited hsv-2 replication in a do ... | 2006 | 16434713 |
| high prevalence of sexually transmitted diseases among men who have sex with men in jiangsu province, china. | : the objective of this study was to investigate the prevalence of sexually transmitted diseases (stds), including hiv infection, and sexual risk behaviors among men who have sex with men (msm) in jiangsu province, china. | 2006 | 16432484 |
| herpes simplex virus type 2 (hsv-2) seroprevalence at the time of hiv-1 diagnosis and seroincidence after hiv-1 diagnosis in an ethnically diverse cohort of hiv-1-infected persons. | the objective of this study was to determine herpes simplex virus type 2 (hsv-2) seroprevalence at hiv-1 diagnosis and seroincidence > or =1 year after hiv-1 diagnosis. | 2006 | 16432480 |
| detection of pathogens causing genital ulcer disease by multiplex polymerase chain reaction. | to establish a multiplex polymerase chain reaction (m-pcr) assay for simultaneous detection of pathogens causing genital ulcer disease (gud). | 2005 | 16422259 |
| modeling the sexual transmissibility of human papillomavirus infection using stochastic computer simulation and empirical data from a cohort study of young women in montreal, canada. | the authors estimated plausible ranges of the probability of human papillomavirus (hpv) transmission per coital act among newly forming couples by using stochastic computer simulation. comparative empirical data were obtained in 1996-2001 from a cohort study of female university students in montreal, canada. female prevalence and frequency of sexual intercourse and condom use were set equal to those in the cohort. simulations included 240 combinations of male prevalence, the relative risk for pr ... | 2006 | 16421235 |
| oral viral infections and the therapeutic use of antiviral agents in dentistry. | this paper reviews the current concepts of viral classification, infection and replication. the clinical presentation of common oral viral infections encountered in the dental practice are discussed, including: herpes simplex virus types 1 and 2; epstein-barr virus; varicella-zoster virus; coxsackie virus; human papilloma virus; and human immunodeficiency virus. the diagnosis, principles of management and pharmacological agents available for the treatment of oral viral infections are also discus ... | 2005 | 16416715 |
| acute retinal necrosis diagnosed in a child with chronic panuveitis. | to report the case of an immunocompetent child with herpes simplex virus-2 (hsv-2) acute retinal necrosis (arn) syndrome, who was considered to have an idiopathic unilateral panuveitis sensitive to steroid treatment. | 2006 | 16411098 |
| virological, serological and epidemiological study of 255 consecutive cases of genital herpes in a sexually transmitted disease clinic of paris (france): a prospective study. | some studies (mostly retrospective) have pointed to an increasing frequency (up to 60%) of herpes simplex virus type 1 (hsv-1) in genital herpes (gh), but they were biased towards severe or atypical cases. we wished to evaluate the frequency of hsv-1 in patients attending our clinic for both first and recurrent episodes of gh. all patients (men and women) with genital lesions compatible with gh were included in a prospective study between may 1999 and april 2002. for all patients a standardized ... | 2006 | 16409679 |
| famciclovir for the treatment of recurrent genital and labial herpes lesions. | famciclovir (famvir, novartis) is an effective treatment for herpes zoster and herpes simplex. two separate studies recently examined the effectiveness of single high doses of famciclovir for treating recurrent genital herpes and labial herpes (cold sores). in the randomized, placebo-controlled studies, patients initiated treatment at the first onset of symptoms. for the treatment of genital herpes, a 1,000 mg b.i.d. dose of famciclovir had significant advantages over the placebo, reducing the t ... | 2005 | 16408140 |
| interleukin-21 mrna expression during virus infections. | interleukin-21 is a cytokine with profound impact on the proliferation and differentiation of activated leukocytes of both the innate and adaptive immune system. in experiments in vitro, antigen activation induces il-21 production in cd4+ t cells. where, when, and how the proliferative and activational effects of il-21 on different leukocytes come into play in vivo in an immune response has so far not been fully investigated. we show here for the first time in vivo, that il-21 mrna is produced i ... | 2006 | 16406655 |
| rnai tackles a sexually transmitted disease. | 2006 | 16404395 | |
| effect of metal complexes of acyclovir and its acetylated derivative on herpes simplex virus 1 and herpes simplex virus 2 replication. | the effect of zinc, nickel, cobalt and cadmium complexes of acyclovir (acv) and its omicron-acetylated derivative (ac-acv) on the replication of wild type (wt) and acv-resistant (acv(r)) strains of herpes simplex virus 1 (hsv-1) and herpes simplex virus 2 (hsv-2) was examined. according to cytotoxicity, these compounds followed the order ni-acv chloride > cd-acv 3 ni-acv nitrate > acv = zn-acv nitrate = ac-acv = zn-ac-acv > zn-acv chloride > co-acv. besides ac-acv, the only active complexes in i ... | 2005 | 16402682 |
| sexually transmitted infections, blood-borne viruses and risk behaviour in an australian senior high school population--the shlirp study. | to determine the feasibility and acceptability of screening for sexually transmitted infections and blood-borne viruses and to study the profile of sexual activity and other risk behaviours in a senior high school population. | 2005 | 16402670 |
| etiology of aseptic meningitis and encephalitis in an adult population. | to investigate the etiology of aseptic meningitis and encephalitis in an adult population using modern microbiologic methods. | 2006 | 16401850 |
| neurotropic viruses and cerebral palsy: population based case-control study. | to investigate the association between cerebral palsy and direct evidence for perinatal exposure to neurotropic viruses. | 2006 | 16399770 |
| a rare case of hsv-2 encephalitis. | herpes simplex viruses (hsv), and especially hsv-1, are the most common cause of acute, sporadic viral encephalitis. hsv-2 is an uncommon cause of encephalitis. we report a rare case of hsv-2 encephalitis that was free of genital lesions. in terms of the patient's case history, she had a cesarean section four months before, herpes labialis 30 days before, varicella zoster 20 days before. we discuss the possibility that postpartum stress may be one of the factors in this case. | 2005 | 16397423 |
| virucidal activity of a beta-triketone-rich essential oil of leptospermum scoparium (manuka oil) against hsv-1 and hsv-2 in cell culture. | the inhibitory activity of manuka oil against herpes simplex virus type 1 (hsv-1) and herpes simplex virus type 2 (hsv-2) was tested in vitro on rc-37 cells (monkey kidney cells) using a plaque reduction assay. in order to determine the mode of antiviral action of the essential oil, manuka oil was added at different times to the cells or viruses during the infection cycle. both hsv types were significantly inhibited when the viruses were pretreated with manuka oil 1 h prior to cell infection. at ... | 2005 | 16395648 |
| high seroprevalence of hsv-1 and hsv-2 in std clinic attendees and non-high risk controls: a case control study at a referral hospital in south india. | in asia, hsv seroprevalence studies are sparse and they have recorded lower prevalence of hsv infection, especially hsv-2. | 2005 | 16394357 |
| synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. | a series of cyclic and acyclic nucleoside analogues derived from 3-hydroxy-4-pyridinone were synthesized using the vorbrüggen reaction. iron chelation studies, and antiviral evaluation against a broad panel of viruses, were performed. the pk(a) value of ligand 25 and the stability constant of the corresponding iron(iii) complex were compared to those of deferiprone. the pfe(3+) values were found to be similar. some compounds showed moderate activity against both wild-type hsv-1 and hsv-2, as wel ... | 2006 | 16392791 |
| [study on the relationship between genesis and development of cervical cancer and the infection of human papillomavirus type 16/18, human herpesvirus ii and cytomegalovirus]. | to investigate the correlation between genesis and the development of cervical cancer and infection of human papillomavirus (hpv) type 16/18, human herpesvirus ii (hsv- ii) and cytomegalovirus(cmv). | 2005 | 16390015 |
| rapid determination of antiviral drug susceptibility of herpes simplex virus types 1 and 2 by real-time pcr. | an antiviral drug susceptibility assay of herpes simplex virus (hsv) was developed using real-time pcr quantification of intracellular viral dna load. the number of hsv dna copies within vero cells after 24 h infection was strongly correlated with the number of plaques obtained after 72 h infection. antiviral drug susceptibility of hsv was determined after virus growth for 24h by measuring the reduction of intracellular hsv dna in the presence of increasing concentrations of either acyclovir (ac ... | 2006 | 16388859 |
| interstitial cystitis and infectious agents. | interstitial cystitis (ic) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. the disease tends to affect caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. few population based epidemiological studies of ic have been performed. we analyzed a case of interstitial cystitis in a 42-year-old non-smoker woman. in two biopsy samples the presence of viral dna of human polyomavirus bk (bkv), human herpes virus type 1 and type 2 (hhv- ... | 2005 | 16388730 |
| risk factors influencing hiv infection incidence in a rural african population: a nested case-control study. | risk factors influencing the incidence of human immunodeficiency virus (hiv) infection were investigated in a case-control study nested within a community-randomized trial of treatment of syndromic sexually transmitted infections (stis) in rural tanzania. | 2006 | 16388496 |
| the receptor-binding region of human apolipoprotein e has direct anti-infective activity. | the apoe genotype has a uniquely strong influence on the outcome of viral infection. the mechanism is unknown, although one possibility is direct inhibition of viral entry into cells. | 2006 | 16388493 |
| etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. | the purpose of the present study was to determine pathogens and behaviors associated with nongonococcal urethritis (ngu) and the usefulness of the urethral smear in predicting the presence of pathogens. | 2006 | 16388480 |
| treatment of intravaginal hsv-2 infection in mice: a comparison of cpg oligodeoxynucleotides and resiquimod (r-848). | the mammalian innate immune system recognizes pathogens via a series of pattern-recognition receptors such as the toll-like receptors (tlr) that interact with pathogen-associated molecular patterns (pamps) and lead to the rapid activation of innate immune cells. in this study, we compared the efficacy of cpg odn (a tlr9 agonist) and resiquimod (r-848; a tlr7/8 agonist) for topical immunoprophylaxis or immunotherapy of vaginal herpes simplex virus type 2 (hsv-2) infection in mice. efficacy agains ... | 2006 | 16377001 |
| sexually transmitted infections among female sex workers in yunnan, china. | a cross-sectional prevalence survey of sexually transmitted infections (stis) was conducted among female sex workers (fsws) in kunming, yunnan province, china. a total of 505 fsws participated in the survey. all eligible participants gave informed consent. demographic, behavioral, and clinical information of the participants was gathered by direct structured interviews. tampon swabs were collected to test for chlamydia trachomatis, nesseria gonorrhoeae, and trichomonas vaginalis and serum specim ... | 2005 | 16375618 |
| chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (hsv-2) co-infected host cells. | epidemiological and clinical studies have shown that double infection with herpes simplex virus type 2 (hsv-2) and chlamydia trachomatis occurs in vivo. we hypothesized that co-infection would alter replication of these agents. to test this hypothesis, hela cells were infected with c. trachomatis serovar e, followed 24 h later by hsv-2 strain 333. transmission electron microscopic (tem) analyses indicated that, by 10 h after hsv addition, reticulate bodies (rbs) in co-infected cells were swollen ... | 2006 | 16367874 |
| isolation and characterization of a chimpanzee alphaherpesvirus. | although both beta- and gammaherpesviruses indigenous to great-ape species have been isolated, to date all alphaherpesviruses isolated from apes have proven to be human viruses [herpes simplex virus types 1 (hsv1) and 2 (hsv2) or varicella-zoster virus]. if the alphaherpesviruses have co-evolved with their host species, some if not all ape species should harbour their own alphaherpesviruses. here, the isolation and characterization of an alphaherpesvirus from a chimpanzee (chhv) are described. s ... | 2006 | 16361413 |
| cd8+ t-cells suppress antigen-specific and allogeneic cd4+ t-cell responses to herpes simplex virus type 2-infected human dendritic cells. | in this study we show that human dendritic cells (dc), productively infected with herpes simplex virus type 2 (hsv-2), activate cd8+ t cells that suppress antigen-specific and alloreactive cd4+ t cell expansion. addition of cd8+ t cells to cultures of dc and cd4+ t cells blocked cd4+ t-cell proliferation in response to hsv-2-infected but not to uninfected dc. the effect was independent of prior hsv exposure or cognate mhc class i-restricted cd8-dc recognition as it was induced in cd8+ t cells fr ... | 2005 | 16359228 |
| role of mucosal immunity in preventing genital herpes infection. | the female genital tract is immunologically unique because it must be tolerant to spermatozoa, pregnancy, and vaginal flora, but also protect the host from pathogen challenge. the mucosal response to herpes simplex viruses (hsv), a major cause of genital ulcerative disease and critical co-factor in the hiv/aids epidemic, is complex and consists of the normally acidic vaginal environment, constitutively secreted and induced antimicrobial peptides, complement, and cellular responses mediated by ep ... | 2005 | 16359226 |
| synthesis and antiviral evaluation of novel 4'-hydroxymethyl branched thioapiosyl nucleosides. | in this study, we synthesized novel 4'-hydroxymethyl branched thioapiosyl nucleosides. the thioapiosyl sugar moiety was constructed using sequential ozonolysis and reduction. the natural bases (uracil, thymine, cytosine, and adenine) were efficiently coupled using the vorbrüggen glycosyl condensation procedure (persilyated base and tmsotf). the antiviral activities of the synthesized compounds were evaluated against hiv-1, hsv-1, hsv-2, and hcmv. compound 19 showed moderate anti-hiv activity (ec ... | 2005 | 16353276 |
| antiherpetic activities of flavonoids against herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) in vitro. | flavonoids, a group of low molecular weight phenylbenzopyrones, have various pharmacological properties including antioxidant, anticancer, bactericidal, and anti-inflammatory. we carried out anti-herpetic assays on 18 flavonoids in five classes and a virus-induced cytopathic effect (cpe) inhibitory assay, plaque reduction assay, and yield reduction assay were performed. when flavonoids were applied at various concentrations to vero cells infected by hsv-1 and 2, most of the flavonoids showed inh ... | 2005 | 16350858 |
| impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation. | although some certain infectious pathogens could be detected in the patients with coronary artery disease, the roles of these infectious factors in the development of coronary artery diseases remain largely unknown. since the number of infectious pathogens has been argued to be relative to the coronary artery diseases, we therefore examined whether there is a link between the number of infections and the incidence of in-stent restenosis after stent implantation. | 2005 | 16336815 |
| reducing hiv-1 transmission through prevention strategies targeting hiv-1-seropositive individuals. | prevention efforts for hiv-1 have traditionally focused on those at risk for acquiring the virus. recently, there has been growing interest in directing prevention efforts towards hiv-1-seropositive individuals, who are seeking care in increasing numbers as a result of improving access to antiretroviral therapy in resource-limited countries. biomedical interventions aimed at reducing the spread of hiv-1 by targeting those at risk for transmitting the virus will be guided in part by an understand ... | 2006 | 16332729 |
| cytomegalovirus-associated periodontitis and guillain-barré syndrome. | guillain-barré syndrome (gbs), an autoimmune disorder of the peripheral nervous system, is characterized by rapidly ascending neural paralysis, hyporeflexia, and areflexia. the polyneuropathy of the gbs affects one to four humans per 100,000 of the population annually throughout the world (adults and children). the pathogenesis of gbs remains unclear. however, there are increasing indications that the disease is triggered by a preceding well-established febrile infection by cytomegalovirus (cmv) ... | 2005 | 16332244 |
| herpes simplex virus 2 infection increases hiv acquisition in men and women: systematic review and meta-analysis of longitudinal studies. | to estimate the sex-specific effect of herpes simplex virus type 2 (hsv-2) on the acquisition of hiv infection. | 2006 | 16327322 |
| application of polymerase chain reaction to differentiate herpes simplex virus 1 and 2 serotypes in culture negative intraocular aspirates. | to standardize and apply a polymerase chain reaction (pcr) on the glycoprotein d gene to differentiate herpes simplex virus (hsv) 1 & 2 serotypes in culture negative intraocular specimens. | 2005 | 16327119 |
| aetiology of sexually transmitted infections and response to syndromic treatment in southwest uganda. | to determine the aetiology of genital ulcers and discharges in rural south western uganda and to assess response to syndromic treatment. | 2005 | 16326853 |
| risk factors for herpes simplex virus transmission to pregnant women: a couples study. | this study was undertaken to determine risk factors for herpes simplex virus (hsv) acquisition among at risk pregnant women. | 2005 | 16325589 |
| risk factors for herpes simplex virus transmission to pregnant women: a couples study. | 2005 | 16325587 | |
| head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. | we investigated whether herpes simplex viruses, hsv-1 and hsv-2, are cofactors of head and neck cancer (hnc) in association with tobacco, alcohol, or hpv-16 infection. the study included 164 hnc cases and 295 controls. serologic tests were used to distinguish hsv-1 and hsv-2. antibodies to anti-vlp hpv-16 and hpv-16 e6 and e7 were evaluated by elisa. after adjusting for age, tobacco, alcohol use, and number of sexual partners, risk of cancer was not significantly increased in those with hsv-1 [a ... | 2006 | 16324878 |
| [mesenchymal dysplasia of heart valves, cystic medianecrosis of the aorta and herpetic infection]. | histologic and immunohistochemical studies (use of antibodies for viruses of herpes simplex type 1 and 2, desmin, vimentin, sma as well as polymerase chain reaction to dna of viruses of herpes simplex) were made on the material of the valves taken from 1326 patients with valvular heart disease, the ascending aorta of 30 patients with aneurysm, valves of 35 deceased patients without cardiovascular pathology. as a result, expression of viruses of herpes simplex type 1 and/or 2 was found in all cas ... | 2005 | 16323474 |
| pro 2000 gel inhibits hiv and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. | microbicides used to prevent the transmission of human immunodeficiency virus (hiv) are advancing to clinical trials on the basis of activity observed in vitro and in animal models. however, no data demonstrate activity of microbicides after application in humans. this study was designed to determine the antiviral activity in cervicovaginal lavage (cvl) samples collected after intravaginal application of 0.5% pro 2000 gel (indevus). | 2006 | 16323128 |
| cmv retinitis in a patient with good syndrome. | to describe cytomegalovirus (cmv) retinitis in a patient with good syndrome. | 2005 | 16321895 |
| intravenous foscarnet in the management of acyclovir-resistant herpes simplex virus type 2 in acute retinal necrosis in children. | diagnosis and management of acute retinal necrosis (arn) in children that does not respond to systemic acyclovir treatment can be challenging. we report two cases of arn secondary to herpes simplex virus (hsv) type 2 that was resistant to acyclovir but was treated successfully with intravenous foscarnet. | 2005 | 16319793 |
| herpes simplex virus-associated acute liver failure: a difficult diagnosis with a poor prognosis. | we report 5 cases of acute liver failure related to herpes simplex (hsv) infection in 1 immunocompetent and 4 immunosuppressed patients. one patient was too ill for liver transplantation indication. three patients, among the 4 listed, underwent liver transplantation. three patients died 11 days to 1 year after transplantation and 2 patients died 2 to 3 days after admission. all presented with fever and none with skin lesions. the diagnosis of hsv-related hepatitis was made antemortem in only 2 p ... | 2005 | 16315311 |
| herpes simplex virus type 2 (hsv-2) western blot confirmatory testing among men testing positive for hsv-2 using the focus enzyme-linked immunosorbent assay in a sexually transmitted disease clinic. | the objective of this study was to define the positive predictive value (ppv) of the focus herpes simplex virus type 2 (hsv-2) enzyme-linked immunosorbent assay (elisa) in a low hsv-2 prevalence population and to develop a new test interpretation algorithm. | 2005 | 16314775 |
| hydrocephalus in herpes simplex type 2 meningitis. | a 34-year-old woman presented to hospital with symptoms of meningitis, later confirmed to be due to herpes simplex virus type 2. she developed hydrocephalus on day 2 of her admission. we describe the first case of hydrocephalus associated with herpes simplex type 2 meningitis in an adult. | 2006 | 16313967 |
| in vitro sensitivity of clinical isolates and drug-resistant mutants of herpes simplex virus against seven antiviral drugs. | 1989 | 16312794 | |
| a novel pharmacological approach to herpes virus infections. | 1989 | 16312792 | |
| an sirna-based microbicide protects mice from lethal herpes simplex virus 2 infection. | herpes simplex virus 2 (hsv-2) infection causes significant morbidity and is an important cofactor for the transmission of hiv infection. a microbicide to prevent sexual transmission of hsv-2 would contribute substantially to controlling the spread of hiv and other infections. because rna interference (rnai) provides effective antiviral defence in plants and other organisms, several studies have focused on harnessing rnai to inhibit viral infection. here we show that vaginal instillation of smal ... | 2006 | 16306938 |
| herpes simplex virus and human papillomavirus infection in cervical disease in argentine women. | the aim of the present study was to determine that prevalence of herpes simplex virus (hsv) type 1 and 2 in cervical samples from argentine women and to assess the role of hsv-2 in cervical cancer. a sample of 79 normal and 200 neoplastic cervical tissues (35 invasive cervical carcinomas, 75 high-grade squamous intraepithelial lesions, 79 low-grade squamous intraepithelial lesions and 11 abnormal squamous cells of undermined significance) was analyzed for herpes simplex and human papillomavirus ... | 2006 | 16306783 |
| management of recurrent genital herpes: a survey of uk genitourinary medicine clinics in 2003. | we carried out a survey of all uk genitourinary (gu) medicine clinics, via postal questionnaire, in order to evaluate the current management of recurrent genital herpes (rgh) in the gu medicine setting. respondents were invited to answer questions regarding various aspects of herpes simplex virus (hsv) management. there was a 62% response rate. analysis of the returned surveys revealed that the vast majority of clinics (96%) provided drug treatment for rgh, with 81% having a clinic policy for th ... | 2005 | 16303073 |
| chronic herpes simplex virus type-2 infection and hiv viral load. | by december 2003, the estimated adult hiv/aids prevalence rate in sub-saharan africa was 7.5-8.5%, and rates of herpes simplex virus type-2 (hsv-2) infection among adults aged >30 years ranged from 60% to 82%. however, little is known about the natural history of hiv/hsv-2 co-infection in this population. we evaluated hiv viral load and cd4+ cell counts among persons with and without chronic hsv-2 co-infection in a cross-sectional study of hiv-infected persons not receiving antiretroviral therap ... | 2005 | 16303067 |
| human herpesvirus 6 in bronchalveolar lavage fluid after lung transplantation: a risk factor for bronchiolitis obliterans syndrome? | bronchiolitis obliterans syndrome (bos) is the limiting factor to long-term survival after lung transplantation. previous studies suggested respiratory viral tract infections are associated with the development of bos. to identify the impact of virus detection in bronchoalveolar lavage (bal) fluid, we analyzed bal samples from 87 consecutive lung transplant recipients for human herpesvirus (hhv)-6, epstein-barr virus, herpes simplex virus 1/2, cytomegalovirus, respiratory syncytical virus and ad ... | 2005 | 16303014 |
| anti-herpes virus activity of dunbaria bella prain. | the herpes inhibitory effect of dunbaria bella prain (fabaceae), a thai medicinal plant traditionally used to treat viral infections was investigated. using a bioassay-guided fractionation procedure, tertiary fractionation of a dichloromethane-methanol plant extract afforded a partially purified fraction (fr.372) equally active against replication of herpes simplex virus (hsv) types 1 and 2. the 50% inhibitory concentration determined by a viral yield-inhibition assay was 1.21-1.25 microg/ml and ... | 2006 | 16298095 |
| intratypic variations among thai herpes simplex virus (hsv) isolates determined by restriction fragment length polymorphism (rflp) analysis. | whole genomic polymorphisms for 20 hsv-1 and 20 hsv-2 isolates from thai patients were analyzed by means of restriction fragment length polymorphism (rflp) analysis using 4 restriction endonucleases: bamhi, kpnl, hindiii, and ecori. variations in cleavage sites among the hsv-1 and hsv-2 isolates were compared to the cleavage patterns of standard hsv-1 strain kos and hsv-2 strain baylor 186. although 70% of hsv-1 isolates with bamhi digestion, 50% with kpnl, 75% with hindiii and 70% with ecori di ... | 2005 | 16295545 |
| viral infections of renal allografts--an immunohistochemical and ultrastructural study. | viral infections have been recognized as an integral part of both graft injury and rejection. on routine histology, viral infections are diagnosed only when fully established, by the presence of viral inclusions or cytopathic effect. although renal transplants are routinely done in many centres in india, the incidence of viral infections is largely unkown. this study was aimed at detecting 5 viral infections namely, cytomegalovirus (cmv), bk polyoma virus (bkv), herpes simplex virus1 and 2 (hsv1 ... | 2004 | 16295465 |
| herpes simplex virus type 2 recurrent meningitis (mollaret's meningitis): a consideration for the recurrent pathogenesis. | we report a 44-year-old japanese woman with herpes simplex virus (hsv) type 2 recurrent meningitis (mollaret's meningitis). the diagnosis was confirmed by nested polymerase chain reaction in her cerebrospinal fluid, but the patient's conventional hsv antibodies by complement fixation, neutralizing test or enzyme immunoassay showed low titres with low lymphoproliferative response. several similar cases are discussed. although the reason for the recurrent pathogenesis is uncertain, our report sugg ... | 2005 | 16291273 |
| development of the loop-mediated isothermal amplification method for rapid detection of cytomegalovirus dna. | cytomegalovirus (cmv) loop-mediated isothermal amplification (lamp) was performed on dna extracted from cmv (ad-169)-, herpes simplex virus (hsv) 1 (kos)-, hsv-2 (186)-, varicella-zoster virus (oka-vaccine)-, human herpesvirus (hhv)-6 a (u1102)-, hhv-6 b (z29)-, and hhv-7 (rk)-infected cells. although amplified cmv demonstrated typical ladder patterns, no lamp product was detected in reactions performed with other viral dnas. the sensitivity of the cmv lamp was 500 copies/tube, as determined by ... | 2006 | 16289345 |
| effect of immunization with herpes simplex virus type-1 (hsv-1) glycoprotein d (gd) plus the immune enhancer gpi-0100 on infection with hsv-1 or hsv-2. | these studies were performed to determine the effects of gpi-0100, a semi synthetic quillaja saponin analog, formulated with herpes simplex virus type-1 (hsv-1) glycoprotein d (gd) on immunity to hsv. skh-1 hairless mice, used as a model of herpes labialis, inoculated with hsv-1 results in facial lesions, virus replication and mortality. mortality rates, lesion scores and viral titers were significantly reduced in skh-1 mice immunized with gd/gpi-0100 prior to cutaneous inoculation with hsv-1 an ... | 2006 | 16288820 |
| false-positive serological test results for lyme disease in a patient with acute herpes simplex virus type 2 infection. | 2005 | 16288417 | |
| impact of immunization with glycoprotein d2/as04 on herpes simplex virus type 2 shedding into the genital tract in guinea pigs that become infected. | in recent clinical trials, a vaccine that contained herpes simplex virus type 2 (hsv-2) glycoprotein d (gd2) and the adjuvant as04 afforded hsv-seronegative women significant protection against hsv-2 genital disease and limited protection against infection. similarly, in guinea pigs, immunization with the vaccine provided significant protection against genital hsv-2 disease but did not prevent mucosal infection. we explored the impact of immunization on the magnitude of latent virus infection an ... | 2005 | 16288376 |
| an ounce of prevention. | 2005 | 16287798 | |
| the relationship between condom use and herpes simplex virus acquisition. | few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (hsv-2) and hsv type 1 (hsv-1) acquisition. | 2005 | 16287791 |
| summaries for patients. condom use and genital herpes. | 2005 | 16287786 | |
| hiv infection and sexually transmitted infections among men who have sex with men in senegal. | no epidemiological study has been conducted on hiv and vulnerability to sexually transmitted diseases (sti) among men who have sex with men (msm) in sub-saharan africa. | 2005 | 16284463 |
| the cotton rat provides a novel model to study genital herpes infection and to evaluate preventive strategies. | prevention of genital herpes and other sexually transmitted infections (sti) is a critical health priority because of the overwhelming impact on women and infants and the epidemiological association with human immunodeficiency virus (hiv)/aids. small animal models are essential for evaluating strategies for prevention or treatment of sti. neither the murine nor the guinea pig model of genital herpes fully recapitulates human disease. we demonstrate that herpes simplex virus type 2 (hsv-2) readil ... | 2005 | 16282463 |
| clearance of herpes simplex virus type 2 by cd8+ t cells requires gamma interferon and either perforin- or fas-mediated cytolytic mechanisms. | the t-cell-mediated resolution of herpes simplex virus type 2 (hsv-2) genital infections is not fully understood. in these studies, the mechanisms by which cd8+ t cells clear virus from the genital epithelium were examined. ovalbumin (ova)-specific cd8+ t cells from ot-i transgenic mice cleared a thymidine kinase-deficient, ovalbumin-expressing hsv-2 virus (hsv-2 tk- ova) from the genital epithelium of recipient mice, and clearance was abrogated by in vivo neutralization of gamma interferon (ifn ... | 2005 | 16282454 |
| synthesis and antiviral activity of novel anomeric branched carbocyclic nucleosides. | novel anomeric branched carbocyclic nucleosides were synthesized from 1,3-dihydroxy acetone. 4'-hydroxymethyl was installed by [3,3]-sigmatropic rearrangement reaction and 1'-methyl group was introduced by carbonyl addition of methylmagnesium bromide. the coupling of nucleosidic bases and desilylation afforded a series of novel nucleosides. the synthesized compounds 16-19 were evaluated for their antiviral activity against hiv-1, hsv-1, hsv-2, and emcv. compounds 16 and 19 exhibit toxicity non-r ... | 2005 | 16276962 |
| genital herpes: a review. | genital herpes simplex virus infection is a recurrent, lifelong disease with no cure. the strongest predictor for infection is a person's number of lifetime sex partners. the natural history includes first-episode mucocutaneous infection, establishment of latency in the dorsal root ganglion, and subsequent reactivation. most infections are transmitted via asymptomatic viral shedding. classic outbreaks consist of a skin prodrome and possible constitutional symptoms such as headache, fever, and in ... | 2005 | 16273819 |
| neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection. | we show that genital infection with neurotropic hsv type 2 (hsv-2) induced a significant increase of the neuropeptide substance p (sp) within the genital tract of mice. sp was shown to weakly interfere with the hsv-2 replication. furthermore, lack of sp signaling through the use of mice deficient in the sp receptor, neurokinin 1 receptor (nk1r), revealed an important role for sp in the innate defense against hsv-2. nk1r-deficient mice had significantly enhanced levels of hsv-2 in the genital tra ... | 2005 | 16272337 |
| macrophage inflammatory protein-1alpha expression plasmid enhances dna vaccine-induced immune responses against hsv-2. | in this study, we examined the effectiveness of macrophage inflammatory protein (mip)-1alpha cdna as a hsv-2 dna vaccine adjuvant. pcdna3-gd (pgd) and pcdna3-mip-1alpha (pmip-1alpha) were co-injected to examine the modulatory effects of mip-1alpha on immune phenotype and protection against lethal challenge with hsv-2. we found that th-cell proliferative responses were dramatically enhanced by co-injection of pgd and pmip-1alpha compared with injection of pgd alone. the secretion of il-2 and ifn- ... | 2005 | 16266314 |
| sex with women as a risk factor for herpes simplex virus type 2 among young men who have sex with men in baltimore. | herpes simplex virus type 2 is common among msm and is a risk factor for transmission of hiv. the findings of studies investigating the relationship between infection with hsv-2 and number of sex partners among msm are inconsistent and rarely distinguish between male and female partners. | 2005 | 16254544 |
| organotypic epithelial raft cultures as a model for evaluating compounds against alphaherpesviruses. | the course of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) and varicella-zoster virus (vzv) infections in squamous epithelial cells cultured in a three-dimensional organotypic raft culture was tested. in these raft cultures, normal human keratinocytes isolated from neonatal foreskins grown at the air-liquid interface stratified and differentiated, reproducing a fully differentiated epithelium. typical cytopathic changes identical to those found in the squamous epithelium in vivo, inclu ... | 2005 | 16251311 |
| synthesis, physicochemical properties and antiviral activities of ester prodrugs of ganciclovir. | the purpose of this study was to synthesize a series of diester prodrugs of ganciclovir (gcv), for improving ocular and oral bioavailability and therapeutic activity. solubility, logp, ph stability profile, in vitro antiviral activity, cytotoxicity, inhibition profile and ocular tissue hydrolysis of the gcv prodrugs were measured. val-val-gcv and val-gly-gcv diesters were found to exhibit greater aqueous stability compared to val-gcv and gly-val-gcv while ocular tissue hydrolysis demonstrated va ... | 2005 | 16242278 |
| effects of non toxic doses of acyclovir on nitric oxide and cellular death responses in herpesvirus types 1 and 2 infected hep-2 cells. | herpes simplex virus type-1 (hsv-1) and type-2 (hsv-2) are among the most "successful" pathogens and code for a variety of proteins to direct the apoptosis/necrosis responses of the cells they infect. nitric oxide (no) is an important intracellular signaling molecule in pathological processes. acyclovir (acv) is a chain terminator that targets the viral dna polymerase as an antiviral agent. in this study, no signals, and apoptosis/necrosis responses of hep-2 cells were compared when infected by ... | 2005 | 16240692 |
| detection of human herpesviruses and polyomaviruses dna in a group of patients with relapsing-remitting multiple sclerosis. | multiple sclerosis (ms) is an inflammatory disease of the central nervous system whose pathological features consist of white matter plaques of primary demyelinization and loss of oligodendrocytes. various risk factors have been associated with ms susceptibility. we have focused this study on different viruses. in particular in the present study we used pcr to search for the genomic dna of hhv-1, hhv-2, hhv-8, bkv and jcv in urine and peripheral blood mononuclear cells (pbmc) samples from 44 rel ... | 2005 | 16240691 |
| reducing the risk of transmitting genital herpes: advances in understanding and therapy. | this review considers the epidemiology and impact of genital herpes, discusses how herpes simplex virus-2 (hsv-2) is transmitted, and reviews data on methods of reducing the risk of hsv transmission. | 2005 | 16238897 |
| case records of the massachusetts general hospital. case 32-2005. a 34-year-old hiv-positive woman who desired to become pregnant. | 2005 | 16236744 | |
| cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. | defining and preserving the innate antiviral activity found in cervicovaginal secretions is critical. cervicovaginal lavage (cvl) samples were obtained from 20 healthy women and evaluated for anti-herpes simplex virus (hsv) activity. cvl samples reduced hsv-2 yields by 23-fold (median), and the anti-hsv activity of cvl samples correlated with the concentration of human neutrophil peptides (hnp)-1-3. both cvl samples and hnp-1-3 interacted with virus and prevented entry after binding. substantial ... | 2005 | 16235171 |
| hypertrophic herpes simplex simulating anal neoplasia in aids patients: report of five cases. | five patients (4 males; mean age, 46.4 years) with painful verrucous perianal lesions caused by herpes simplex virus are described. all patients had had aids for a long time and were using highly active antiretroviral therapy. cd4+ counts ranged from 73 to 370/mm3. all lesions were submitted to resection under subdural anesthesia. histologic examinations revealed epithelial hyperplasia and dense inflammatory process, composed mainly of lymphocytes and plasma cells, extended just to the hypodermi ... | 2005 | 16228826 |
| use of "biokit hsv-2 rapid assay" to improve the positive predictive value of focus herpeselect hsv-2 elisa. | commercially available assays to detect antibodies to the herpes simplex virus type 2 (hsv-2)-specific glycoprotein gg-2 have markedly improved serologic diagnosis of hsv-2 infection. however, even tests with high specificity can have low positive predictive values in low prevalence populations. hsv-2 is a chronic, life-long viral infection that requires both medical attention and potential alterations in health care strategy. as such, the concern for false positive diagnoses is high confirmator ... | 2005 | 16225691 |
| glycoprotein d adjuvant herpes simplex virus vaccine. | herpes simplex virus (hsv) type-1 and -2 are common infections that can cause primary and recurrent herpes labialis and genitalis, as well as gingivostomatitis, keratoconjunctivitis, encephalitis, disseminated infections in immunocompromised persons and neonatal infections. despite several decades of hsv vaccine development, no effective vaccine has been developed until recently. the following review of the genital hsv-2 glycoprotein d (gd2t, t is for truncated) subunit vaccine formulated with a ... | 2005 | 16221064 |
| evaluation of dendrimer spl7013, a lead microbicide candidate against herpes simplex viruses. | dendrimers are a novel class of polyanionic macromolecules with broad-spectrum antiviral activities and minimal toxicities. a new generation of amide dendrimer, spl7013, was evaluated as a lead microbicide candidate against herpes simplex viruses (hsv). the plaque reduction assays showed that the 50% effective concentrations (ec(50)) determined by pre-treatment of cells were 2.0 microg/ml for hsv-1 and 0.5 microg/ml for hsv-2. inhibitory effects were also observed on hsv-infected cells with ec(5 ... | 2005 | 16219368 |
| [detection of sexually transmitted pathogens in patients with hematospermia]. | although the current literature attributes most cases of hematospermia to an infectious agent, identification of the specific pathogens involved has been limited. | 2005 | 16218534 |
| current and potential uses of imiquimod. | imiquimod, an imidazoquinoline amine, is an immune response modifier first fda-approved for the treatment of external genital and perianal warts in 1997. since its appearance on the market, its antiviral and antitumor properties have been used in the treatment of a variety of dermatologic conditions. in this review article, the basic mechanism of action of imiquimod, current fda-approved and non-fda-approved uses of imiquimod, and key points of medication application frequency, possible adverse ... | 2005 | 16217984 |
| seroprevalence of herpes simplex virus 1 and 2 and correlates of infection in israel. | the prevalence of infections with herpes viruses 1 and 2 (hsv1 and hsv2) have significantly changed in the developed countries during the last three decades. this study provides up-to-date estimates of hsv-1 and hsv-2 seroprevalence and information on the correlates of infection in a representative sample of the israeli population. | 2006 | 16213591 |
| a randomized controlled trial of a replication defective (gh deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects. | a replication incompetent herpes virus lacking the glycoprotein h gene has been developed as a potential therapeutic vaccine for genital herpes. | 2006 | 16213066 |
| dendritic cell biology in herpesvirus infections. | 2005 | 16212521 | |
| development of multiplex pcrs for detection of common viral pathogens and agents of congenital infections. | potential causes of congenital infection include toxoplasma gondii and viruses such as cytomegalovirus (cmv), enterovirus, hepatitis c virus, herpes simplex virus types 1 and 2 (hsv-1 and -2), human herpesvirus types 6, 7, and 8, lymphocytic choriomeningitis virus, parvovirus, rubella virus, and varicella-zoster virus. testing for each of these agents using nucleic acid tests is time consuming and the availability of clinical samples such as amniotic fluid or neonatal blood is often limited. the ... | 2005 | 16207970 |
| health indicators among low income women who report a history of sex work: the population based northern california young women's survey. | we examined differences in demographic characteristics, hiv related risk behaviour, prevalence of sexually transmitted infections (sti), and hiv and other health concerns among women with and without a history of sex work. | 2005 | 16199746 |
| genital herpes complicating pregnancy. | approximately 22% of pregnant women are infected with herpes simplex virus (hsv)-2, and 2% of women will acquire hsv during pregnancy. remarkably, up to 90% of these women are undiagnosed because they are asymptomatic or have subtle symptoms attributed to other vulvovaginal disorders. diagnosis of genital herpes relies on laboratory confirmation with culture or polymerase chain reaction assay of genital lesions and type-specific glycoprotein g-based serologic testing. neonatal herpes is the most ... | 2005 | 16199646 |