Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| sexual differences in prevalence of a new species of trypanosome infecting túngara frogs. | trypanosomes are a diverse group of protozoan parasites of vertebrates transmitted by a variety of hematophagous invertebrate vectors. anuran trypanosomes and their vectors have received relatively little attention even though these parasites have been reported from frog and toad species worldwide. blood samples collected from túngara frogs (engystomops pustulosus), a neotropical anuran species heavily preyed upon by eavesdropping frog-biting midges (corethrella spp.), were examined for trypanos ... | 2016 | 26977404 |
| low seroprevalence indicates vulnerability of eastern and central sudan to infection with chikungunya virus. | outbreaks of infections with chikungunya virus (chikv) have previously been reported from sudan but the prevalence in the general population is unknown. we investigated the seroprevalence of chikv infection in 379 serum samples from patients with fever in the outpatient clinics of three hospitals in eastern and central sudan. the seroprevalence was 1.8%, indicating that chikv infections are rare in these parts of sudan. as the vector aedes aegypti is endemic in this area, the population is at ri ... | 2016 | 26974266 |
| spatial and temporal epidemiology of lumpy skin disease in the middle east, 2012-2015. | lumpy skin disease virus (lsdv) is an infectious disease of cattle that can have severe economic implications. new lsd outbreaks are currently circulating in the middle east (me). since 2012, severe outbreaks were reported in cattle across the region. characterizing the spatial and temporal dynamics of lsdv in cattle populations is prerequisite for guiding successful surveillance and control efforts at a regional level in the me. here, we aim to model the ecological niche of lsdv and identify ep ... | 2016 | 26973845 |
| zika virus and its implication in transfusion safety. | 2016 | 26969782 | |
| the convergence of a virus, mosquitoes, and human travel in globalizing the zika epidemic. | the zika virus was first identified in 1947 in the zika forest of uganda. it was discovered in a rhesus monkey that had been placed in a cage on a sentinel platform in the forest by the virus research institute. when this writer visited the institute and the zika forest in 1961, work was underway to identify mosquito species at various levels of the tree canopy. this was done through the placement of traps at various levels of a 120-foot-high steel tower which this writer climbed. at that time, ... | 2016 | 26969497 |
| de novo transcriptome assembly of the grapevine phylloxera allows identification of genes differentially expressed between leaf- and root-feeding forms. | grapevine phylloxera, an insect related to true aphids, is a major historic pest of viticulture only controlled through the selection of resistant rootstocks or through quarantine regulations where grapevine is cultivated own-rooted. transcriptomic data could help understand the bases of its original life-traits, including a striking case of polyphenism, with forms feeding on roots and forms feeding in leaf-galls. comparisons with true aphids (for which complete genomes have been sequenced) shou ... | 2016 | 26968158 |
| dengue in java, indonesia: relevance of mosquito indices as risk predictors. | no vaccine is currently available for dengue virus (denv), therefore control programmes usually focus on managing mosquito vector populations. entomological surveys provide the most common means of characterising vector populations and predicting the risk of local dengue virus transmission. despite indonesia being a country strongly affected by denv, only limited information is available on the local factors affecting denv transmission and the suitability of available survey methods for assessin ... | 2016 | 26967524 |
| factors associated with correct and consistent insecticide treated curtain use in iquitos, peru. | dengue is an arthropod-borne virus of great public health importance, and control of its mosquito vectors is currently the only available method for prevention. previous research has suggested that insecticide treated curtains (itcs) can lower dengue vector infestations in houses. this observational study investigated individual and household-level socio-demographic factors associated with correct and consistent use of itcs in iquitos, peru. a baseline knowledge, attitudes, and practices (kap) s ... | 2016 | 26967157 |
| newly emerging parasitic threats for human health: national and international trends. | 2016 | 26966685 | |
| brazil's scientists scramble to solve the zika puzzle. | the world health organization has declared the recent leap in the number of microcephaly cases and their suspected association with zika virus a public health emergency of international concern. ana bispo tells andréia azevedo soares why brazil should have some scientific answers in coming months. | 0 | 26966326 |
| effect of two commercial herbicides on life history traits of a human disease vector, aedes aegypti, in the laboratory setting. | some mosquito species utilize the small niches of water that are abundant in farmland habitats. these niches are susceptible to effects from agricultural pesticides, many of which are applied aerially over large tracts of land. one principal form of weed control in agricultural systems involves the development of herbicide-tolerant crops. the impact of sub-agricultural levels of these herbicides on mosquito survival and life-history traits of resulting adults have not been determined. the aim of ... | 2016 | 26965703 |
| endogenously-expressed nh2-terminus of circumsporozoite protein interferes with sporozoite invasion of mosquito salivary glands. | the circumsporozoite protein is the most abundant polypeptide expressed by sporozoites, the malaria parasite stage capable of infecting humans. sporozoite invasion of mosquito salivary glands prior to transmission is likely mediated by a receptor/ligand-like interaction of the parasites with the target tissues, and the amino (nh2)-terminal portion of csp is involved in this interaction but not the tsr region on the carboxyl (c)-terminus. peptides based on the nh2-terminal domain could compete wi ... | 2016 | 26964736 |
| determinants of host feeding success by anopheles farauti. | the proportion of blood meals that mosquitoes take from a host species is a function of the interplay of extrinsic (abundance and location of potential hosts) and intrinsic (innate preference) factors. a mark-release-recapture experiment addressed whether host preference in a population of anopheles farauti was uniform or if there were anthropophilic and zoophilic subpopulations. the corresponding fitness associated with selecting different hosts for blood meals was compared by measuring fecundi ... | 2016 | 26964528 |
| integrating transgenic vector manipulation with clinical interventions to manage vector-borne diseases. | many vector-borne diseases lack effective vaccines and medications, and the limitations of traditional vector control have inspired novel approaches based on using genetic engineering to manipulate vector populations and thereby reduce transmission. yet both the short- and long-term epidemiological effects of these transgenic strategies are highly uncertain. if neither vaccines, medications, nor transgenic strategies can by themselves suffice for managing vector-borne diseases, integrating these ... | 2016 | 26962871 |
| zika virus: new clinical syndromes and its emergence in the western hemisphere. | zika virus (zikv) had remained a relatively obscure flavivirus until a recent series of outbreaks accompanied by unexpectedly severe clinical complications brought this virus into the spotlight as causing an infection of global public health concern. in this review, we discuss the history and epidemiology of zikv infection, recent outbreaks in oceania and the emergence of zikv in the western hemisphere, newly ascribed complications of zikv infection, including guillain-barré syndrome and microce ... | 2016 | 26962217 |
| mevalonate-farnesal biosynthesis in ticks: comparative synganglion transcriptomics and a new perspective. | juvenile hormone (jh) controls the growth, development, metamorphosis, and reproduction of insects. for many years, the general assumption has been that jh regulates tick and other acarine development and reproduction the same as in insects. although researchers have not been able to find the common insect jhs in hard and soft tick species and jh applications appear to have no effect on tick development, it is difficult to prove the negative or to determine whether precursors to jh are made in t ... | 2016 | 26959814 |
| history, epidemiology, and clinical manifestations of zika: a systematic review. | to describe salient epidemiological characteristics of zika virus outbreaks across the world and to examine the clinical presentations, complications, and atypical manifestations related to their occurrence in recent history. | 0 | 26959260 |
| erratum. topically applied aaeiap1 double-stranded rna kills female adults of aedes aegypti. journal of medical entomology 45(3):414–420. | 0 | 26957585 | |
| zika virus outbreak: 'a perfect storm'. | 2016 | 26956448 | |
| zika virus infection: new threat in global health. | 2016 | 26955231 | |
| a survey of the 2014 dengue fever epidemic in guangzhou, china. | in 2014, a serious dengue outbreak in guangzhou occurred, consisting of 37 354 laboratory confirmed cases of infection. in this study, the clinical picture of dengue fever due to dengue virus (denv) type 1 in guangzhou was described. clinical and laboratory data collected by studying 726 sera of suspected clinical cases from hospitals and 328 sera of healthy persons from two residence communities were analyzed during the outbreak, and 484 patients were diagnosed with an acute dengue infection. f ... | 2015 | 26954995 |
| spermatogenesis drives rapid gene creation and masculinization of the x chromosome in stalk-eyed flies (diopsidae). | throughout their evolutionary history, genomes acquire new genetic material that facilitates phenotypic innovation and diversification. developmental processes associated with reproduction are particularly likely to involve novel genes. abundant gene creation impacts the evolution of chromosomal gene content and general regulatory mechanisms such as dosage compensation. numerous studies in model organisms have found complex and, at times contradictory, relationships among these genomic attribute ... | 2016 | 26951781 |
| identification of autophagy in the pine wood nematode bursaphelenchus xylophilus and the molecular characterization and functional analysis of two novel autophagy-related genes, bxatg1 and bxatg8. | the pine wood nematode, bursaphelenchus xylophilus, causes huge economic losses in pine forests, has a complex life cycle, and shows the remarkable ability to survive under unfavorable and changing environmental conditions. this ability may be related to autophagy, which is still poorly understood in b. xylophilus and no autophagy-related genes have been previously characterized. in this study, transmission electron microscopy was used to confirm that autophagy exists in b. xylophilus. the full- ... | 2016 | 26950119 |
| pyrosequencing the midgut transcriptome of the banana weevil cosmopolites sordidus (germar) (coleoptera: curculionidae) reveals multiple protease-like transcripts. | the banana weevil cosmopolites sordidus is an important and serious insect pest in most banana and plantain-growing areas of the world. in spite of the economic importance of this insect pest very little genomic and transcriptomic information exists for this species. in the present study, we characterized the midgut transcriptome of c. sordidus using massive 454-pyrosequencing. we generated over 590,000 sequencing reads that assembled into 30,840 contigs with more than 400 bp, representing a sig ... | 2016 | 26949943 |
| developmental neurogenetics of sexual dimorphism in aedes aegypti. | sexual dimorphism, a poorly understood but crucial aspect of vector mosquito biology, encompasses sex-specific physical, physiological, and behavioral traits related to mosquito reproduction. the study of mosquito sexual dimorphism has largely focused on analysis of the differences between adult female and male mosquitoes, particularly with respect to sex-specific behaviors related to disease transmission. however, sexually dimorphic behaviors are the products of differential gene expression tha ... | 2015 | 26949699 |
| acquisition of exogenous haem is essential for tick reproduction. | haem and iron homeostasis in most eukaryotic cells is based on a balanced flux between haem biosynthesis and haem oxygenase-mediated degradation. unlike most eukaryotes, ticks possess an incomplete haem biosynthetic pathway and, together with other (non-haematophagous) mites, lack a gene encoding haem oxygenase. we demonstrated, by membrane feeding, that ticks do not acquire bioavailable iron from haemoglobin-derived haem. however, ticks require dietary haemoglobin as an exogenous source of haem ... | 2016 | 26949258 |
| characterization of a fasciola gigantica protein carrying two dm9 domains reveals cellular relocalization property. | even at the present age of whole-organism analysis, e.g., genomics, transcriptomics, and proteomics, the biological roles of many proteins remain unresolved. classified among the proteins of unknown function is a family of proteins harboring repeats of the dm9 domain, a 60-75 amino acids motif first described in a small number of drosophila melanogaster proteins. proteins may carry two or more dm9 domains either in combination with other domains or as their sole constituent. here we have charact ... | 2016 | 26946400 |
| rna sequencing to characterize transcriptional changes of sexual maturation and mating in the female oriental fruit fly bactrocera dorsalis. | female reproductive potential plays a significant role in the survival and stability of species, and sexual maturation and mating processes are crucial. however, our knowledge of the reproductive genes involved in sexual maturation and mating has been largely limited to model organisms. the oriental fruit fly bactrocera dorsalis is a highly invasive agricultural pest, known to cause major economic losses; thus, it is of great value to understand the transcriptional changes involved in sexual mat ... | 2016 | 26946038 |
| amino acids trigger down-regulation of superoxide via torc pathway in the midgut of rhodnius prolixus. | sensing incoming nutrients is an important and critical event for intestinal cells to sustain life of the whole organism. the torc is a major protein complex involved in monitoring the nutritional status and is activated by elevated amino acid concentrations. an important feature of haematophagy is that huge amounts of blood are ingested in a single meal, which results in the release of large quantities of amino acids, together with the haemoglobin prosthetic group, haem, which decomposes hydrop ... | 2016 | 26945025 |
| an animal homolog of plant mep/amt transporters promotes ammonia excretion by the anal papillae of the disease vector mosquito aedes aegypti. | the transcripts of three putative ammonia (nh3/nh4 (+)) transporters, rhesus-like glycoproteins aerh50-1, aerh50-2 and amt/mep-like aeamt1 were detected in the anal papillae of larval aedes aegypti quantitative pcr studies revealed 12-fold higher transcript levels of aeamt1 in anal papillae relative to aerh50-1, and levels of aerh50-2 were even lower. immunoblotting revealed aeamt1 in anal papillae as a pre-protein with putative monomeric and trimeric forms. aeamt1 was immunolocalized to the bas ... | 2016 | 26944496 |
| aedes aegypti control in brazil. | 2016 | 26944024 | |
| deltamethrin-mediated survival, behavior, and oenocyte morphology of insecticide-susceptible and resistant yellow fever mosquitos (aedes aegypti). | insecticide use is the prevailing control tactic for the mosquito aedes aegypti, a vector of several human viruses, which leads to ever-increasing problems of insecticide resistance in populations of this insect pest species. the underlying mechanisms of insecticide resistance may be linked to the metabolism of insecticides by various cells, including oenocytes. oenocytes are ectodermal cells responsible for lipid metabolism and detoxification. the goal of this study was to evaluate the subletha ... | 2016 | 26943998 |
| [dengue, zika and chikungunya]. | arboviruses are transmitted by arthropods, including those responsible for the current pandemic: alphavirus (chikungunya) and flaviviruses (dengue and zika). its importance increased in the americas over the past 20 years. the main vectors are aedes aegypti and a. albopictus. dengue infection provides long lasting immunity against the specific serotype and temporary to the other three. subsequent infection by another serotype determines more serious disease. there is a registered vaccine for den ... | 2016 | 26942903 |
| evaluation of the larvicidal efficacy of five indigenous weeds against an indian strain of dengue vector, aedes aegypti l. (diptera: culicidae). | background and objectives. aedes aegypti, dengue fever mosquito, is primarily associated with the transmission of dengue and chikungunya in tropical and subtropical regions of the world. the present investigations were carried out to assess the larvicidal efficiency of five indigenous weeds against ae. aegypti. methods. the 1,000 ppm hexane and ethanol extracts prepared from the leaves and stem of five plants (achyranthes aspera, cassia occidentalis, catharanthus roseus, lantana camara, and xant ... | 2016 | 26941996 |
| intra-epidemic evolutionary dynamics of a dengue virus type 1 population reveal mutant spectra that correlate with disease transmission. | dengue virus (denv) is currently the most prevalent mosquito-borne viral pathogen. denvs naturally exist as highly heterogeneous populations. even though the descriptions on denv diversity are plentiful, only a few studies have narrated the dynamics of intra-epidemic virus diversity at a fine scale. such accounts are important to decipher the reciprocal relationship between viral evolutionary dynamics and disease transmission that shape dengue epidemiology. in the current study, we present a mic ... | 2016 | 26940650 |
| the expanding spectrum of modes of transmission of zika virus: a global concern. | 2016 | 26939897 | |
| zika virus and pregnancy: a review of the literature and clinical considerations. | the latest zika virus (zikv) outbreak has reached epidemic proportions as it spreads throughout south and central america. in november 2015, the brazilian ministry of health reported a 20-fold increase in the number of cases of neonatal microcephaly, which corresponds geographically and temporally to the zikv outbreak. case reports have provided some evidence of a causal link between maternal zikv infection, fetal microcephaly, and intracranial calcifications. the sparse data regarding zikv in p ... | 2016 | 26939047 |
| distribution of voltage-gated sodium channel (nav) alleles among the aedes aegypti populations in central java province and its association with resistance to pyrethroid insecticides. | the emergence of insecticide resistant aedes aegypti mosquitoes has hampered dengue control efforts. who susceptibility tests, using several pyrethroid compounds, were conducted on ae. aegypti larvae that were collected and raised to adulthood from semarang, surakarta, kudus and jepara in java. the aanav gene fragment encompassing kdr polymorphic sites from both susceptible and resistant mosquitoes was amplified, and polymorphisms were associated with the resistant phenotype. the insecticide sus ... | 2016 | 26939002 |
| differential susceptibilities of aedes aegypti and aedes albopictus from the americas to zika virus. | since the major outbreak in 2007 in the yap island, zika virus (zikv) causing dengue-like syndromes has affected multiple islands of the south pacific region. in may 2015, the virus was detected in brazil and then spread through south and central america. in december 2015, zikv was detected in french guiana and martinique. the aim of the study was to evaluate the vector competence of the mosquito spp. aedes aegypti and aedes albopictus from the caribbean (martinique, guadeloupe), north america ( ... | 2016 | 26938868 |
| a review of bioinsecticidal activity of solanaceae alkaloids. | only a small percentage of insect species are pests. however, pest species cause significant losses in agricultural and forest crops, and many are vectors of diseases. currently, many scientists are focused on developing new tools to control insect populations, including secondary plant metabolites, e.g., alkaloids, glycoalkaloids, terpenoids, organic acids and alcohols, which show promise for use in plant protection. these compounds can affect insects at all levels of biological organization, b ... | 2016 | 26938561 |
| co-distribution and co-infection of chikungunya and dengue viruses. | chikungunya and dengue infections are spatio-temporally related. the current review aims to determine the geographic limits of chikungunya, dengue and the principal mosquito vectors for both viruses and to synthesise current epidemiological understanding of their co-distribution. | 2016 | 26936191 |
| entomological aspects and the role of human behaviour in malaria transmission in a highland region of the republic of yemen. | the republic of yemen has the highest incidence of malaria in the arabian peninsula, yet little is known of its vectors or transmission dynamics. | 2016 | 26932794 |
| declining malaria, rising of dengue and zika virus: insights for mosquito vector control. | the fight against mosquito-borne diseases is a challenge of huge public health importance. to our mind, 2015 was an extraordinary year for malaria control, due to three hot news: the nobel prize to youyou tu for the discovery of artemisinin, the development of the first vaccine against plasmodium falciparum malaria [i.e. rts,s/as01 (rts,s)], and the fall of malaria infection rates worldwide, with special reference to sub-saharan africa. however, there are major challenges that still deserve atte ... | 2016 | 26932263 |
| genomic approaches for understanding dengue: insights from the virus, vector, and host. | the incidence and geographic range of dengue have increased dramatically in recent decades. climate change, rapid urbanization and increased global travel have facilitated the spread of both efficient mosquito vectors and the four dengue virus serotypes between population centers. at the same time, significant advances in genomics approaches have provided insights into host-pathogen interactions, immunogenetics, and viral evolution in both humans and mosquitoes. here, we review these advances an ... | 2016 | 26931545 |
| research on climate and dengue in malaysia: a systematic review. | dengue is a climate-sensitive infectious disease. climate-based dengue early warning may be a simple, low-cost, and effective tool for enhancing surveillance and control. scientific studies on climate and dengue in local context form the basis for advancing the development of a climate-based early warning system. this study aims to review the current status of scientific studies in climate and dengue and the prospect or challenges of such research on a climate-based dengue early warning system i ... | 0 | 26931438 |
| contact bioassays with phenoxybenzyl and tetrafluorobenzyl pyrethroids against target-site and metabolic resistant mosquitoes. | mosquito strains that exhibit increased tolerance to the chemical class of compounds with a sodium channel modulator mode of action (pyrethroids and pyrethrins) are typically described as "pyrethroid resistant". resistance to pyrethroids is an increasingly important challenge in the control of mosquito-borne diseases, such as malaria or dengue, because one of the main interventions (the distribution of large numbers of long-lasting insecticide-treated bed nets) currently relies entirely on long- ... | 2016 | 26930058 |
| forecasting chikungunya spread in the americas via data-driven empirical approaches. | chikungunya virus (chikv) is endemic to africa and asia, but the asian genotype invaded the americas in 2013. the fast increase of human infections in the american epidemic emphasized the urgency of developing detailed predictions of case numbers and the potential geographic spread of this disease. | 2016 | 26928307 |
| evaluation of the activity of the essential oil from an ornamental flower against aedes aegypti: electrophysiology, molecular dynamics and behavioral assays. | dengue fever has spread worldwide and affects millions of people every year in tropical and subtropical regions of africa, asia, europe and america. since there is no effective vaccine against the dengue virus, prevention of disease transmission depends entirely on regulating the vector (aedes aegypti) or interrupting human-vector contact. the aim of this study was to assess the oviposition deterrent activity of essential oils of three cultivars of torch ginger (etlingera elatior, zingiberaceae) ... | 2016 | 26927837 |
| zika virus outbreak in brazil. | zika virus (zikv) infection is spreading rapidly within the americas after originating from an outbreak in brazil. we describe the current zikv infection epidemic in brazil and the neurological symptoms arising. first cases of an acute exanthematic disease were reported in brazil's northeast region at the end of 2014. in march 2015, autochthonous zikv was determined to be the causative agent of the exanthematic disease. as cases of neurological syndromes in regions where zikv, dengue and/or chik ... | 2016 | 26927450 |
| nutritional signaling regulates vitellogenin synthesis and egg development through juvenile hormone in nilaparvata lugens (stål). | insect female reproduction which comprises the synthesis of vitellogenein (vg) in the fat body and its incorporation into developing oocytes, needs a large amount of energy and food resources. our previous studies found that juvenile hormone (jh) regulates vitellogenesis in the brown planthopper, nilaparvata lugens. here, we report on the role of jh in nutrient-regulated vg synthesis and egg development. we first cloned the genes coding for juvenile hormone acid methyltransferase (jhamt) which i ... | 2016 | 26927076 |
| multiple evolutionary selections involved in synonymous codon usages in the streptococcus agalactiae genome. | streptococcus agalactiae is an important human and animal pathogen. to better understand the genetic features and evolution of s. agalactiae, multiple factors influencing synonymous codon usage patterns in s. agalactiae were analyzed in this study. a- and u-ending rich codons were used in s. agalactiae function genes through the overall codon usage analysis, indicating that adenine (a)/thymine (t) compositional constraints might contribute an important role to the synonymous codon usage pattern. ... | 2016 | 26927064 |
| the zika outbreak of the 21st century. | the zika virus outbreak has captivated the attention of the global audience and information has spread rapidly and wildly through the internet and other media channels. this virus was first identified in 1947, when it was isolated from a sentinel rhesus monkey placed by british scientists working at the yellow fever research laboratory located in the zika forest area of uganda, hence its name, and is transmitted primarily by the mosquito vector, aedes aegypti. the fact that the rhesus macaque is ... | 2016 | 26925496 |
| wolbachia biocontrol strategies for arboviral diseases and the potential influence of resident wolbachia strains in mosquitoes. | arboviruses transmitted by mosquitoes are a major cause of human disease worldwide. the absence of vaccines and effective vector control strategies has resulted in the need for novel mosquito control strategies. the endosymbiotic bacterium wolbachia has been proposed to form the basis for an effective mosquito biocontrol strategy. resident strains of wolbachia inhibit viral replication in drosophila fruit flies and induce a reproductive phenotype known as cytoplasmic incompatibility that allows ... | 2016 | 26925368 |
| repellent and mosquitocidal effects of leaf extracts of clausena anisata against the aedes aegypti mosquito (diptera: culicidae). | mosquitoes are rapidly developing resistance to insecticides that millions of people relied on to protect themselves from the diseases they carry, thereby creating a need to develop new insecticides. clausena anisata is used traditionally as an insect repellent by various communities in africa and asia. for this study, the repellency and adulticidal activities of leaf extracts and compounds isolated from this plant species were evaluated against the yellow fever mosquito, aedes aegypti. in the t ... | 2016 | 26924698 |
| innovative dengue vector control interventions in latin america: what do they cost? | five studies were conducted in fortaleza (brazil), girardot (colombia), machala (ecuador), acapulco (mexico), and salto (uruguay) to assess dengue vector control interventions tailored to the context. the studies involved the community explicitly in the implementation, and focused on the most productive breeding places for aedes aegypti. this article reports the cost analysis of these interventions. | 0 | 26924235 |
| highly divergent dengue virus type 1 genotype sets a new distance record. | dengue viruses (denvs) are the leading cause of mosquito-borne viral disease of humans. they exist in both endemic and sylvatic ecotypes. in 2014, a viremic patient who had recently visited the rainforests of brunei returned to australia displaying symptoms consistent with denv infection. a unique denv strain was subsequently isolated from the patient, which we propose belongs to a new genotype within denv serotype 1 (denv-1). bayesian evolutionary phylogenetic analysis suggests that the putativ ... | 2016 | 26924208 |
| antibody-dependent enhancement of dengue virus infection inhibits rlr-mediated type-i ifn-independent signalling through upregulation of cellular autophagy. | antibody dependent enhancement (ade) of dengue virus (denv) infection is identified as the main risk factor of severe dengue diseases. through opsonization by subneutralizing or non-neutralizing antibodies, denv infection suppresses innate cell immunity to facilitate viral replication. however, it is largely unknown whether suppression of type-i ifn is necessary for a successful ade infection. here, we report that both denv and denv-ade infection induce an early isg (nos2) expression through rlr ... | 2016 | 26923481 |
| the use of aedes aegypti larvae attractants to enhance the effectiveness of larvicides. | aedes aegypti (l.) is an important dengue, chikungunya, and yellow fever vector. immature stages of this species inhabit human-made containers placed in residential landscapes, and the application of larvicides inside containers that cannot be eliminated is still considered a priority in control programs. larvicidal efficacy is influenced by several factors, including the formulation used, the water quality, and the susceptibility of larvae, among others. if an attractant can be incorporated int ... | 2016 | 26922177 |
| recent advances in understanding dengue. | dengue is an emerging threat to billions of people worldwide. in the last 20 years, the incidence has increased four-fold and this trend appears to be continuing. caused by one of four viral serotypes, dengue can present as a wide range of clinical phenotypes with the severe end of the spectrum being defined by a syndrome of capillary leak, coagulopathy, and organ impairment. the pathogenesis of severe disease is thought to be in part immune mediated, but the exact mechanisms remain to be define ... | 2016 | 26918159 |
| chikungunya: epidemiology. | chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. joint pains may last months or years. it is vectored primarily by the tropical and sub-tropical mosquito, aedes aegypti, but is also found to be transmitted by aedes albopictus, a mosquito species that can also be found in more temperate climates. in recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the ... | 2016 | 26918158 |
| evolution of the assassin's arms: insights from a phylogeny of combined transcriptomic and ribosomal dna data (heteroptera: reduvioidea). | assassin bugs (reduvioidea) are one of the most diverse (>7,000 spp.) lineages of predatory animals and have evolved an astounding diversity of raptorial leg modifications for handling prey. the evolution of these modifications is not well understood due to the lack of a robust phylogeny, especially at deeper nodes. we here utilize refined data from transcriptomes (370 loci) to stabilize the backbone phylogeny of reduvioidea, revealing the position of major clades (e.g., the chagas disease vecto ... | 2016 | 26916580 |
| the untapped cell biology of neglected tropical diseases. | the world health organization lists a constellation of 17 tropical diseases that afflict approximately one in six individuals on the planet and, until recently, few resources have been devoted to the treatment and eradication of those diseases. they are often referred to as the diseases of the "bottom billion," because they are most prevalent among the poorest individuals in impoverished tropical nations. however, the few studies that have been performed reveal an extraordinary world of molecula ... | 2016 | 26915691 |
| small rna profiling in dengue virus 2-infected aedes mosquito cells reveals viral pirnas and novel host mirnas. | in aedes mosquitoes, infections with arthropod-borne viruses (arboviruses) trigger or modulate the expression of various classes of viral and host-derived small rnas, including small interfering rnas (sirnas), piwi interacting rnas (pirnas), and micrornas (mirnas). viral sirnas are at the core of the antiviral rna interference machinery, one of the key pathways that limit virus replication in invertebrates. besides sirnas, aedes mosquitoes and cells derived from these insects produce arbovirus-d ... | 2016 | 26914027 |
| immunodominant dengue virus-specific cd8+ t cell responses are associated with a memory pd-1+ phenotype. | dengue disease is a large public health problem that mainly afflicts tropical and subtropical regions. understanding of the correlates of protection against dengue virus (denv) is poor and hinders the development of a successful human vaccine. the present study aims to define denv-specific cd8(+)t cell responses in general and those of hla alleles associated with dominant responses in particular. in human blood donors in nicaragua, we observed a striking dominance of hla b-restricted responses i ... | 2016 | 26912627 |
| culex quinquefasciatus larval microbiomes vary with instar and exposure to common wastewater contaminants. | like many insects, mosquitoes, rely on endosymbionts to grow and develop. these can be acquired from the environment. we used next generation 454 pyrosequencing to discern the whole-body microbiome of the mosquito species culex quinquefasciatus in various larval stadia and following exposure to common pharmaceutical and personal care products (ppcps) found in wastewater. ppcp treatments included environmentally-relevant concentrations; 1) a combination of common antibiotics, 2) a combination of ... | 2016 | 26912375 |
| unique pfk regulatory property from some mosquito vectors of disease, and from drosophila melanogaster. | arthropod-borne diseases are some of the most rapidly spreading diseases. reducing the vector population is currently the only effective way to reduce case numbers. central metabolic pathways are potential targets to control vector populations, but have not been well explored to this aim. the information available on energy metabolism, as a way to control lifespan and dispersion through flight of dipteran vectors, is inadequate. | 2016 | 26911930 |
| toxin stability improvement and toxicity increase against dipteran and lepidopteran larvae of bacillus thuringiensis crystal protein cry2aa. | bacillus thuringiensis δ-endotoxins are the most widely used biopesticides for controlling economically important crop pests and disease vectors. improving their efficacy is of great benefit. here, an improvement in cry2aa δ-endotoxin toxicity was attempted via a cry gene over expression system using p20 from b. thuringiensis israelensis. | 2016 | 26910489 |
| fabrication of metal nanoparticles from fungi and metal salts: scope and application. | fungi secrete enzymes and proteins as reducing agents which can be used for the synthesis of metal nanoparticles from metal salts. large-scale production of nanoparticles from diverse fungal strains has great potential since they can be grown even in vitro. in recent years, various approaches have been made to maximize the yield of nanoparticles of varying shape, size, and stability. they have been characterized by thermogravimetric analysis, x-ray diffractometry, sem/tem, zeta potential measure ... | 2016 | 26909778 |
| flaviviruses as a cause of undifferentiated fever in sindh province, pakistan: a preliminary report. | arboviral diseases are expanding worldwide, yet global surveillance is often limited due to diplomatic and cultural barriers between nations. with human encroachment into new habitats, mosquito-borne viruses are also invading new areas. the actual prevalence of expanding arboviruses is unknown in pakistan due to inappropriate diagnosis and poor testing for arboviral diseases. the primary objective of this study was to document evidence of flavivirus infections as the cause of undifferentiated fe ... | 2016 | 26909342 |
| a primary screening and applying of plant volatiles as repellents to control whitefly bemisia tabaci (gennadius) on tomato. | with the goal of finding a new way to reduce population densities of bemisia tabaci biotype q in greenhouses, seven repellent volatile chemicals and their combinations were screened. the mixture of dlco (d-limonene, citral and olive oil (63:7:30)) had a better cost performance(sc50 = 22.59 mg/ml)to repel whiteflies from settling than the other mixtures or single chemicals. in the greenhouse, in both the choice test and the no-choice tests, the number of adult whiteflies that settled on 1% dlco-t ... | 2016 | 26907368 |
| insight into the mode of action of haedoxan a from phryma leptostachya. | haedoxan a (ha) is a major active ingredient in the herbaceous perennial plant lopseed (phryma leptostachya l.), which is used as a natural insecticide against insect pests in east asia. here, we report that ha delayed the decay rate of evoked excitatory junctional potentials (ejps) and increased the frequency of miniature ejps (mejps) on the drosophila neuromuscular junction. ha also caused a significant hyperpolarizing shift of the voltage dependence of fast inactivation of insect sodium chann ... | 2016 | 26907348 |
| chemical diversity and biological properties of secondary metabolites from sea hares of aplysia genus. | the marine environment is an important source of structurally-diverse and biologically-active secondary metabolites. during the last two decades, thousands of compounds were discovered in marine organisms, several of them having inspired the development of new classes of therapeutic agents. marine mollusks constitute a successful phyla in the discovery of new marine natural products (mnps). over a 50-year period from 1963, 116 genera of mollusks contributed innumerous compounds, aplysia being th ... | 2016 | 26907303 |
| structural insights into the aedes aegypti aquaporins and aquaglyceroporins - an in silico study. | there has been a fair bit of understanding on the structure-function relationship of aquaporins (aqps) from plants and vertebrates obtained from available x-ray crystallography data. however, there is a lacuna in understanding the structure of aqps from sanguinivorous insects like the mosquito where it plays a crucial role in survival. in this study, we have built homology models for the aedes aegypti aqps, identified key channel lining residues and compared the structure and sequence with ortho ... | 2016 | 26906718 |
| pupal productivity & nutrient reserves of aedes mosquitoes breeding in sewage drains & other habitats of kolkata, india: implications for habitat expansion & vector management. | the quality of breeding sites is reflected through the pupal productivity and the life history traits of aedes mosquitoes. using nutrient reserves and pupal productivity of aedes as indicators, the larval habitats including sewage drains were characterized to highlight the habitat expansion and vector management. | 0 | 26905248 |
| spatial distribution & physicochemical characterization of the breeding habitats of aedes aegypti in & around kolkata, west bengal, india. | dengue infection is endemic in several areas and the dengue virus is transmitted by aedes mosquitoes. thus, it becomes important to understand the breeding ecology of dengue vector and characterize the physicochemical parameters of its breeding habitat. the objective of this study was to analyze the physicochemical parameters of the breeding habitat of the dengue vector and to find out the nutrient composition of the habitat in and around kolkata, west bengal. in addition, a geographic informati ... | 0 | 26905247 |
| observation on dengue cases from a virus diagnostic laboratory of a tertiary care hospital in north india. | the epidemiology of dengue fever (df) is complex in the indian subcontinent as all the four serotypes are circulating. this study reports observations on dengue cases from a virus diagnostic laboratory of a north indian tertiary care hospital catering to areas in and around lucknow, uttar pradesh. | 0 | 26905245 |
| adulticidal & larvicidal efficacy of three neonicotinoids against insecticide susceptible & resistant mosquito strains. | due to ever growing insecticide resistance in mosquitoes to commonly used insecticides in many parts of the globe, there is always a need for introduction of new insecticides for the control of resistant vector mosquitoes. in this study, larvicidal and adulticidal efficacies of three neonicotinoids (imidacloprid, thiacloprid and thiamethoxam) were tested against resistant and susceptible populations of anopheles stephensi liston 1901, aedes (stegomyia) aegypti linnaeus, and culex quinquefasciatu ... | 0 | 26905244 |
| chikungunya virus susceptibility & variation in populations of aedes aegypti (diptera: culicidae) mosquito from india. | although having immense clinical relevance, yet only a few studies have been targeted to understand the chikungunya virus (chikv) susceptibility and growth in aedes aegypti populations from india. this study was undertaken to investigate chikv susceptibility and growth kinetics in ae. aegypti along with genetic heterogeneity of ae. aegypti populations. | 0 | 26905240 |
| chikungunya outbreak in atmakur village, medak district, telangana state, india. | 0 | 26905235 | |
| re-emergence of dengue virus serotype 2 strains in the 2013 outbreak in nepal. | epidemiological interventions and mosquito control are the available measures for dengue control. the former approach uses serotype and genetic information on the circulating virus strains. dengue has been frequently reported from nepal, but this information is mostly lacking. the present study was done to generate a comprehensive clinical and virological picture of a dengue outbreak in nepal during 2013. | 0 | 26905233 |
| aedes mosquitoes and zika virus infection: an a to z of emergence? | 2016 | 26905027 | |
| insulin-related peptide 5 is involved in regulating embryo development and biochemical composition in pea aphid with wing polyphenism. | in aphids there is a fecundity-dispersal trade-off between wingless and winged morphs. recent research on the molecular mechanism of wing morphs associated with dispersal reveals that insulin receptors in the insulin signaling (is) pathway regulate alternation of wing morphs in planthoppers. however, little is known about whether genes in the is pathway are involved in developmental regulation in aphid nymphs with different wing morphs. in this study, we show that expression of the insulin-relat ... | 2016 | 26903881 |
| four emerging arboviral diseases in north america: jamestown canyon, powassan, chikungunya, and zika virus diseases. | arthropod-borne viruses, or arboviruses, are viruses that are transmitted through the bites of mosquitoes, ticks, or sandflies. there are numerous arboviruses throughout the world capable of causing human disease spanning different viral families and genera. recently, jamestown canyon, powassan, chikungunya, and zika viruses have emerged as increasingly important arboviruses that can cause human disease in north america. unfortunately, there are currently no proven disease-modifying therapies fo ... | 2016 | 26903031 |
| mating-induced transcriptome changes in the reproductive tract of female aedes aegypti. | the aedes aegypti mosquito is a significant public health threat, as it is the main vector of dengue and chikungunya viruses. disease control efforts could be enhanced through reproductive manipulation of these vectors. previous work has revealed a relationship between male seminal fluid proteins transferred to females during mating and female post-mating physiology and behavior. to better understand this interplay, we used short-read rna sequencing to identify gene expression changes in the low ... | 2016 | 26901677 |
| comparative study of hippo pathway genes in cellular conveyor belts of a ctenophore and a cnidarian. | the hippo pathway regulates growth rate and organ size in fly and mouse, notably through control of cell proliferation. molecular interactions at the heart of this pathway are known to have originated in the unicellular ancestry of metazoans. they notably involve a cascade of phosphorylations triggered by the kinase hippo, with subsequent nuclear to cytoplasmic shift of yorkie localisation, preventing its binding to the transcription factor scalloped, thereby silencing proliferation genes. there ... | 2016 | 26900447 |
| control of mosquito-borne infectious diseases: sex and gene drive. | sterile male releases have successfully reduced local populations of the dengue vector, aedes aegypti, but challenges remain in scale and in separating sexes before release. the recent discovery of the first mosquito male determining factor (m factor) will facilitate our understanding of the genetic programs that initiate sexual development in mosquitoes. manipulation of the m factor and possible intermediary factors may result in female-to-male conversion or female killing, enabling efficient s ... | 2016 | 26897660 |
| differential juvenile hormone variations in scale insect extreme sexual dimorphism. | scale insects have evolved extreme sexual dimorphism, as demonstrated by sedentary juvenile-like females and ephemeral winged males. this dimorphism is established during the post-embryonic development; however, the underlying regulatory mechanisms have not yet been examined. we herein assessed the role of juvenile hormone (jh) on the diverging developmental pathways occurring in the male and female japanese mealybug planococcus kraunhiae (kuwana). we provide, for the first time, detailed gene e ... | 2016 | 26894583 |
| developing a time series predictive model for dengue in zhongshan, china based on weather and guangzhou dengue surveillance data. | dengue is a re-emerging infectious disease of humans, rapidly growing from endemic areas to dengue-free regions due to favorable conditions. in recent decades, guangzhou has again suffered from several big outbreaks of dengue; as have its neighboring cities. this study aims to examine the impact of dengue epidemics in guangzhou, china, and to develop a predictive model for zhongshan based on local weather conditions and guangzhou dengue surveillance information. | 2016 | 26894570 |
| establishment of a novel primary human skeletal myoblast cellular model for chikungunya virus infection and pathogenesis. | chikungunya virus (chikv) is a re-emerging arbovirus known to cause chronic myalgia and arthralgia and is now considered endemic in countries across asia and africa. the tissue tropism of chikv infection in humans remains, however, ill-defined. due to the fact that myositis is commonly observed in most patients infected with chikv, we sought to develop a clinically relevant cellular model to better understand the pathogenesis of chikv infection. in this study, primary human skeletal muscle myobl ... | 2016 | 26892458 |
| transcriptome analysis and discovery of genes relevant to development in bradysia odoriphaga at three developmental stages. | bradysia odoriphaga (diptera: sciaridae) is the most important pest of chinese chive (allium tuberosum) in asia; however, the molecular genetics are poorly understood. to explore the molecular biological mechanism of development, illumina sequencing and de novo assembly were performed in the third-instar, fourth-instar, and pupal b. odoriphaga. the study resulted in 16.2 gb of clean data and 47,578 unigenes (≥125 bp) contained in 7,632,430 contigs, 46.21% of which were annotated from non-redunda ... | 2016 | 26891450 |
| establishment of a wolbachia superinfection in aedes aegypti mosquitoes as a potential approach for future resistance management. | wolbachia pipientis is an endosymbiotic bacterium estimated to chronically infect between 40-75% of all arthropod species. aedes aegypti, the principle mosquito vector of dengue virus (denv), is not a natural host of wolbachia. the transinfection of wolbachia strains such as walbb, wmel and wmelpop-cla into ae. aegypti has been shown to significantly reduce the vector competence of this mosquito for a range of human pathogens in the laboratory. this has led to wmel-transinfected ae. aegypti curr ... | 2016 | 26891349 |
| local transmission of zika virus--puerto rico, november 23, 2015-january 28, 2016. | zika virus, a mosquito-borne flavivirus, spread to the region of the americas (americas) in mid-2015, and appears to be related to congenital microcephaly and guillain-barré syndrome (1,2). on february 1, 2016, the world health organization (who) declared the occurrence of microcephaly cases in association with zika virus infection to be a public health emergency of international concern.* on december 31, 2015, puerto rico department of health (prdh) reported the first locally acquired (index) c ... | 2016 | 26890470 |
| notes from the field: evidence of zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses--brazil, 2015. | zika virus is a mosquito-borne flavivirus that is related to dengue virus and transmitted primarily by aedes aegypti mosquitoes, with humans acting as the principal amplifying host during outbreaks. zika virus was first reported in brazil in may 2015 (1). by february 9, 2016, local transmission of infection had been reported in 26 countries or territories in the americas.* infection is usually asymptomatic, and, when symptoms are present, typically results in mild and self-limited illness with s ... | 2016 | 26890059 |
| zika virus: diagnostics for an emerging pandemic threat. | zika virus (zikv) is anaedesmosquito-borne flavivirus that emerged in brazil in 2015 and then rapidly spread throughout the tropical and subtropical americas. based on clinical criteria alone, zikv cannot be reliably distinguished from infections with other pathogens that cause an undifferentiated systemic febrile illness, including infections with two common arboviruses, dengue virus and chikungunya virus. this minireview details the methods that are available to diagnose zikv infection. | 2016 | 26888897 |
| emerging role of lipid droplets in aedes aegypti immune response against bacteria and dengue virus. | in mammals, lipid droplets (lds) are ubiquitous organelles that modulate immune and inflammatory responses through the production of lipid mediators. in insects, it is unknown whether lds play any role during the development of immune responses. we show that aedes aegypti aag2 cells - an immune responsive cell lineage - accumulates lds when challenged with enterobacter cloacae, sindbis, and dengue viruses. microarray analysis of aag2 challenged with e.cloacae or infected with dengue virus reveal ... | 2016 | 26887863 |
| phylogenetic analysis of dengue virus 1 isolated from south minas gerais, brazil. | dengue is a major worldwide public health problem, especially in the tropical and subtropical regions of the world. primary infection with a single dengue virus serotype causes a mild, self-limiting febrile illness called dengue fever. however, a subset of patients who experience secondary infection with a different serotype can progress to a more severe form of the disease, called dengue hemorrhagic fever. the four dengue virus serotypes (1-4) are antigenically and genetically distinct and each ... | 2016 | 26887252 |
| deep rna-seq profile reveals biodiversity, plant-microbe interactions and a large family of nbs-lrr resistance genes in walnut (juglans regia) tissues. | deep rna-seq profiling, a revolutionary method used for quantifying transcriptional levels, often includes non-specific transcripts from other co-existing organisms in spite of stringent protocols. using the recently published walnut genome sequence as a filter, we present a broad analysis of the rna-seq derived transcriptome profiles obtained from twenty different tissues to extract the biodiversity and possible plant-microbe interactions in the walnut ecosystem in california. since the residua ... | 2016 | 26883051 |
| polyandry depends on postmating time interval in the dengue vector aedes aegypti. | aedes aegypti is the primary vector of the dengue and chikungunya viruses. after mating, male seminal fluid molecules cause females to become unreceptive to a subsequent mating. this response is often assumed to be immediate and complete, but a growing body of evidence suggests that some females do mate more than once. it is unknown how quickly a female becomes unreceptive to a second mating. furthermore, the degree to which she remains monandrous after laying several batches of eggs has not bee ... | 2016 | 26880776 |
| development of non-defective recombinant densovirus vectors for microrna delivery in the invasive vector mosquito, aedes albopictus. | we previously reported that mosquito densoviruses (mdvs) are potential vectors for delivering foreign nucleic acids into mosquito cells. however, considering existing expression strategies, recombinant viruses would inevitably become replication-defective viruses and lose their ability for secondary transmission. the packaging limitations of the virion represent a barrier for the development of mdvs for viral paratransgenesis or as high-efficiency bioinsecticides. herein, we report the developme ... | 2016 | 26879823 |
| spatial spread of dengue in a non-endemic tropical city in northern argentina. | after more than eighty years dengue reemerged in argentina in 1997. since then, the largest epidemic in terms of geographical extent, magnitude and mortality, was recorded in 2009. in this report we analyzed the den-1 epidemic spread in orán, a mid-size city in a non-endemic tropical area in northern argentina, and its correlation with demographic and socioeconomic factors. cases were diagnosed by elisa between january and june 2009. we applied a space-time and spatial scan statistic under a poi ... | 2016 | 26875764 |