Publications

therapeutic approaches for ophthalmic problems in juvenile rheumatoid arthritis.	juvenile rheumatoid arthritis is a disease of children which is chronic and painful, with the potential to produce permanent disability and blindness in a significant portion of cases. the treatment we provide these children may also disable them. managing this disease process and caring for these patients is a challenging task in which therapeutic efficacy must be continually balanced against treatment morbidity. with respect to ocular disease, we must particularly recognize the difficulties pa ...	2009	2672130
infectious and toxic syndromes from fish and shellfish consumption. a review.	primary care physicians care for large numbers of patients presenting with "food poisoning" or gastroenteritis. when a patient who presents with acute gastrointestinal illness, especially in conjunction with neurologic or cutaneous symptoms, is evaluated, the history should focus on past seafood consumption (particularly raw or undercooked seafood). the infectious syndromes are generally self-limited and respond to supportive care; exceptions are those caused by vibrio cholerae and vibrio vulnif ...	1989	2669661
cannabis--its clinical effects.	the range of clinical, intoxicating, psychological and psychiatric effects of cannabis ('dagga') are reviewed. controversial subjects, such as the entities of toxic cannabis psychosis and the cannabis amotivational syndrome, are discussed.	2009	2669170
rolipram in major depressive disorder: results of a double-blind comparative study with imipramine.	rolipram improves signal transmission in central noradrenergic neurones at a pre- and postsynaptic level, and is thus a novel approach in antidepressant therapy. in order to prove efficacy, tolerance, and safety, several controlled studies are underway. results of a randomized double-blind comparative trial versus imipramine involving 64 in-patients with major depressive disorder (dsm iii) in six independent centers will be presented and discussed. the chosen biometric model provided evidence th ...	2008	2668980
neopterin measured in serum and tissue culture supernates by a competitive enzyme-linked immunosorbant assay.	in this solid-phase competitive enzyme-linked immunosorbant assay for neopterin (a product of activated macrophages) in serum or supernates of cell cultures, we incubate antiserum to neopterin with standards or samples in the presence of solid-phase-bound conjugate of carrier-neopterin. incubation with second antibody labeled with peroxidase then follows, before reaction with substrate. analytical recovery, precision, and sensitivity of this method are similar to those of other immunoassays. the ...	2006	2667801
vibrio vulnificus infection in hawaii.	a life-threatening vibrio vulnificus infection occurred in a 52-year-old korean woman with hepatic cirrhosis. four days after ingesting raw crab, the patient presented to the hospital with nausea, vomiting, fever, hypotension, and hemorrhagic blistering of the left foot. vibrio vulnificus was recovered from both her blood and a foot wound.	1989	2666323
[conventional insulin therapy, infusion pumps, injector syringes. different methods of administration].		2009	2665113
review of cardiovascular findings in humans treated with minoxidil.	minoxidil is an antihypertensive vasodilator with no known capability of inducing human cardiovascular pathology; however, the compound does cause a late, canine-specific lesion of the right atrium and acute right atrial and ventricular papillary muscle changes. in all the autopsy cases of minoxidil-treated humans to date, 9 cases were reported with significant right atrial or other cardiac pathology and were carefully reviewed for similarity to either the early or late canine lesion. three new ...	1989	2665032
the history of responses to epidemic disease in the united states since the 18th century.	history offers some guidance for understanding social and policy responses to the aids epidemic. pertinent themes in the history of responses to epidemic disease in the united states in the past two hundred years include an initial underestimation of the severity of the epidemic; the prevalence of fear and anxiety; flight, denial, and scape-goating as a result of fear; efforts to quarantine and isolate carriers and the sick; the assertion of rational policies by coalitions of business, governmen ...	2009	2664485
perspectives on the hallucinatory process.	hallucinations are common psychiatric symptoms and the hallucinating patient presents a number of nursing problems. although psychiatric nurses have written fairly extensively about hallucinations as a clinical problem, little nursing research has tested commonly recommended nursing interventions. this paper presents a review of interdisciplinary research on hallucinations and synthesizes findings with clinical observations to suggest a number of areas needing greater stress in nursing practice ...	2009	2663771
thrombolytic therapy. a review (2).		2009	2663220
[the link between cholesterol and atherosclerosis: intervention trials].	intervention trials aimed at influencing the course of atherosclerosis by reducing blood cholesterol levels of two types: some of them evaluate the clinical consequences of atherosclerosis, while the others study the disease itself by means of arteriography. several trials of the first type have convincingly shown that the incidence of coronary disease decreases after at least 5 years of medicinal treatment. as for direct visualization trials, they seem to indicate that the development of athero ...	2009	2662362
pulsed-field gel electrophoresis of circular dna.	mobility of supercoiled (form i) and nicked circular (form ii) plasmid dnas was determined on two major forms of pulsed-field electrophoresis, chef and ofage. plasmids with molecular lengths ranging from 2.30 to 17.8 kilobase pairs (kb) were used with saccharomyces cerevisiae chromosomes as standards. agarose gel concentrations were varied from 0.3 to 2.0 percent, with higher percentage gels resolving forms i and ii of smaller plasmids. the pulsing range of 3.7 to 240 seconds resulted in quite v ...	1989	2662139
detection of vibrio vulnificus cytolysin in v. vulnificus-infected mice.	enzyme-linked immunosorbent assays using polyclonal and monoclonal antibodies specific for v. vulnificus cytolysin detected the toxin in an extract of skin lesions and in serum from mice showing local and systemic v. vulnificus disease after subcutaneous injection of the bacterium. the cytolysin also was detected in skin lesions by an indirect immunofluorescence procedure using polyclonal and monoclonal antibodies. our findings provide direct evidence that the cytolysin is produced in vivo durin ...	1989	2658204
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
[relapsing polychondritis. an infrequent cartilage disease].	report of a case affecting a middle-age woman, 48, involving the e.n.t. area only. the aa comment on the features of the disease and report on the good results with medical treatment (prednisolone, indomethacin and dapsone).	2009	2655492
weakness in patients with hemiparesis.	clinical and experimental results are reviewed concerning muscle weakness in patients with hemiparesis after a stroke. the discussion includes the important role that alterations in the physiology of motor units, notably changes in firing rates and muscle fiber atrophy, play in the manifestation of muscle weakness. this role is compared with the lesser role that spasticity (defined as hyperactive stretch reflexes) of the antagonist muscle group appears to play in determining the weakness of agon ...	2009	2655457
bone marrow transplantation for acute lymphoblastic leukaemia in first and second remission.		2009	2653514
no association between post-transplant erythrocytosis, thromboembolic events, and cyclosporine therapy.		2009	2652691
therapeutic implications of tumor heterogeneity.	at the outset of this review, we stated that we wished to raise some questions that challenge the commonly held view that tumor heterogeneity is of major significance to treatment failure. the nature of this challenge is the following: although tumor heterogeneity in sensitivity to therapeutic agents has been demonstrated repeatedly, using isolated subpopulations of cells, primarily in cell culture systems, there is very little work that has been directed toward asking the tough questions about ...	1989	2652316
lead toxicity and iron deficiency in utah migrant children.	we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.	2009	2650572
lead toxicity and iron deficiency in utah migrant children.	we determined the frequency of presumptive iron deficiency and lead toxicity in 198 utah migrant children, ages 9-72 months, during the summer of 1985. there were no confirmed cases of lead toxicity. thirteen per cent of those tested and 30 per cent of the children ages 9-23 months were iron deficient. hematocrit determinations accurately predicted iron deficiency in only 35 per cent of the children confirmed to have this disorder via erythrocyte protoporphyrin screening.	2009	2650572
new system helps prevent medi-cal claim delays.		2009	2649431
internalization and degradation of insulin by a human insulin receptor-v-ros hybrid in chinese hamster ovary cells.	chinese hamster ovary cell lines expressing either the wild-type human insulin receptor or a hybrid molecule in which the tyrosine kinase domain of the insulin receptor is replaced with that of the oncogene, v-ros were examined for their ability to internalize and degrade insulin. cells expressing the hybrid receptor were found to internalize and degrade insulin at approximately half the rate of cells expressing the native insulin receptor. moreover, insulin was incapable of inducing the interna ...	1989	2645866
redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man.	prostacyclin (pgi2) is an inhibitor of platelet function in vitro. we tested the hypothesis that pgi2 is formed in biologically active concentrations at the platelet-vascular interface in man and can be pharmacologically modulated to enhance its inhibitory properties. this became feasible when we developed a microquantitative technique that permits the measurement of eicosanoids in successive 40-microliters aliquots of whole blood emerging from a bleeding time wound. in 13 healthy volunteers the ...	1989	2643628
[necrosis of the bone marrow].	the authors analyzed the incidence of necrosis of the bone marrow in nonselected autopsy material. the studies included 419 cases of various disease types. necrosis of the bone marrow was found in 83 cases (19.8%). it was most frequently observed in patients with neoplastic disease of the hematopoietic and lymphatic systems (26.3%) and malignant neoplasms of different origin (21.9%). in 40% cases necrosis of the bone marrow were accompanied by neoplastic metastases into the hematopoietic tissue, ...	2009	2637982
carotid cave aneurysms.		2009	2635881
[measurement of orthodontic appliance force using prototype sensors].	in introductory remarks the most important biomechanical principles, which are relevant for the research, and conditions which must be satisfied presented in intraoral measuring of orthodontic forces were pointed out. first the aim of the research was defined, and then the investigation of mechanical properties of acrylics as a material for orthodontic appliances were carried out. the type of strain gauges, bonds and measuring system configurations, as well as measuring amplifiers and recording ...	2008	2635572
non-germ cell testicular tumours in nigerians.	non-germ cell testicular tumours are reported to be more common in peoples of negroid and asian descent than in caucasians. this group of tumours comprised seven of sixteen testicular tumours seen in a ten-year period at the university of benin teaching hospital, benin city, nigeria. however, unlike experiences elsewhere in africa and the west indies where paratesticular tumours accounted for a majority of these tumours, malignant lymphomas constituted over 70% of non-germinal testicular tumours ...	2008	2635452
non-germ cell testicular tumours in nigerians.	non-germ cell testicular tumours are reported to be more common in peoples of negroid and asian descent than in caucasians. this group of tumours comprised seven of sixteen testicular tumours seen in a ten-year period at the university of benin teaching hospital, benin city, nigeria. however, unlike experiences elsewhere in africa and the west indies where paratesticular tumours accounted for a majority of these tumours, malignant lymphomas constituted over 70% of non-germinal testicular tumours ...	2008	2635452
short chain fatty acid-induced colitis in mice.	short-chain fatty acids (e.g. acetic, propionic and butyric acid) are metabolic products produced by colonic bacteria. since intra-rectal instillation of dilute acetic acid to rats and cats has been reported to produce a diffuse colitis similar to the human disease, in our study we have investigated the effect of intra-rectal butyric acid in mice. male bka mice (n = 6) received 01 ml of dilute butyric acid by intra-rectal instillation which was flushed out with saline after 10 sec. control anima ...	1989	2634625
myofibroblasts in cotton-induced granulation tissue and the bovine adrenal capsule: morphological aspects.	ultrastructural studies of one week old cotton-induced granulation tissue revealed the presence of polymorphonuclear neutrophils (pmn), macrophages and mast cells, whilst the granulation tissue from two week old cotton implants contained fibroblasts, myofibroblasts and abundant collagen fibres. similarly, the bovine adrenal capsule contained both fibroblasts and myofibroblasts. it is proposed that the bovine adrenal capsule and two week cotton-induced granulation tissue could be utilized as in-v ...	1989	2634624
[psychological approach in nursing. delusion associated with alcoholism].		2007	2632860
studies on medicinal resources from livestock. i. anti-allergic effects of pig bile. (1).	anti-allergic activities of animal biles and commercially available bile acids were evaluated in experimental allergic disease models. pig bile exhibited marked preventive effects on the models of delayed-type hypersensitivity (type iv allergy), picryl chloride-induced contact dermatitis (pc-cd) and sheep red blood cells (srbc)-induced footpad swelling in mice. fel ursi (dried bear gallbladder) also had an inhibitory effect on pc-cd, whereas ox bile, chicken bile and bile acids had no effect on ...	1989	2632089
studies on medicinal resources from livestock. i. anti-allergic effects of pig bile. (1).	anti-allergic activities of animal biles and commercially available bile acids were evaluated in experimental allergic disease models. pig bile exhibited marked preventive effects on the models of delayed-type hypersensitivity (type iv allergy), picryl chloride-induced contact dermatitis (pc-cd) and sheep red blood cells (srbc)-induced footpad swelling in mice. fel ursi (dried bear gallbladder) also had an inhibitory effect on pc-cd, whereas ox bile, chicken bile and bile acids had no effect on ...	1989	2632089
[experience with dilatation of tight esophageal stenoses using a balloon catheter].	the dilatation of oesophageal stenoses with balloon catheters was made in 38 patients with 44 stenoses of different origin. the most frequent stenosis was localized in oesophagogastric or oesophagocolic anastomosis after oesophagectomy, postcorrosive stenoses an those after reflux oesophagitis. the stenoses were mostly of filiform type, the diameter being 1-3 mm (79%) less frequently 4-7 mm (21%). it became possible to dilate 37 stenoses up to 10 to 20 mm, four stenoses to 22 mm. in only three c ...	2008	2632022
[experience with dilatation of tight esophageal stenoses using a balloon catheter].	the dilatation of oesophageal stenoses with balloon catheters was made in 38 patients with 44 stenoses of different origin. the most frequent stenosis was localized in oesophagogastric or oesophagocolic anastomosis after oesophagectomy, postcorrosive stenoses an those after reflux oesophagitis. the stenoses were mostly of filiform type, the diameter being 1-3 mm (79%) less frequently 4-7 mm (21%). it became possible to dilate 37 stenoses up to 10 to 20 mm, four stenoses to 22 mm. in only three c ...	2008	2632022
[reiter's syndrome or lyme disease?].		2008	2632003
[reiter's syndrome or lyme disease?].		2008	2632003
[rational treatment of necrotizing external otitis].	advances in the diagnosis and treatment of necrotizing external otitis (neo) during the past 20 years improved substantially the prognosis of this disease. the use of hyperbaric oxygen therapy greatly potentiates the effect of newly developed highly effective antibiotics. radioisotope examination of the petrous bones facilitates the diagnosis and indicates the time to terminate treatment. medicamentous treatment is preferable to surgical treatment, which is reserved for exceptional very advanced ...	1989	2631997
[rational treatment of necrotizing external otitis].	advances in the diagnosis and treatment of necrotizing external otitis (neo) during the past 20 years improved substantially the prognosis of this disease. the use of hyperbaric oxygen therapy greatly potentiates the effect of newly developed highly effective antibiotics. radioisotope examination of the petrous bones facilitates the diagnosis and indicates the time to terminate treatment. medicamentous treatment is preferable to surgical treatment, which is reserved for exceptional very advanced ...	1989	2631997
assessment of clinical application of test-dose concept for theophylline in patients with respiratory failure.	the possibility of clinical application of test-dose concept for theophylline was assessed in 11 patients with serious underlying disease who required theophylline. based on the pharmacokinetic parameters calculated from the single intravenous aminophylline administration, they received a continuous infusion of aminophylline in order to maintain about 10 micrograms/ml plasma which is considered to be the lowest therapeutic level. plasma levels during a constant rate infusion were assayed at 6:00 ...	2008	2630628
assessment of clinical application of test-dose concept for theophylline in patients with respiratory failure.	the possibility of clinical application of test-dose concept for theophylline was assessed in 11 patients with serious underlying disease who required theophylline. based on the pharmacokinetic parameters calculated from the single intravenous aminophylline administration, they received a continuous infusion of aminophylline in order to maintain about 10 micrograms/ml plasma which is considered to be the lowest therapeutic level. plasma levels during a constant rate infusion were assayed at 6:00 ...	2008	2630628
maize phosphoenolpyruvate carboxylase involved in c4 photosynthesis: nucleotide sequence analysis of the 5' flanking region of the gene.	to clone the genomic dna fragment containing the putative promoter region of the gene for phosphoenolpyruvate carboxylase [ec 4.1.1.31] involved in c4 photosynthesis (c4-type pepc), maize genomic libraries were screened. on probing with a 384-bp fragment from the n-terminal coding region of the maize cdna for c4-type pepc, four ecori-fragments differing in the restriction map were cloned, reflecting the presence of a small gene family. southern blot analyses were carried out on the genomic dna a ...	2008	2628434
[alpha-amylase polymorphism. 1. a comparative study of alpha-amylase hp and gm].	individual phenotypes, phenotypical and genetic frequencies of the alpha-amylase enzyme have been established by means of populational genetic researches. the most common phenotype is amyla amyl2a (85.15%) followed by amyla amyl2a 2b (6.27%), amylaib amyl2a (5.37%), amyl ia amyl2a 2b (2.15%), amyla amyl2b (0.53%), amylc amyl2b (0.35%), amylc amyl2a 2b (0.18%). the difference between the observed and theoretically expected phenotypes of amy, hp and m gm(1) is insignificant. the examined contingen ...	2008	2627896
survival of vibrio vulnificus in shellstock and shucked oysters (crassostrea gigas and crassostrea virginica) and effects of isolation medium on recovery.	when two species of shellstock oysters were artificially contaminated with vibrio vulnificus, the bacterium survived when the oysters were stored at 10 degrees c and below. large numbers of endogenous v. vulnificus cells were found after 7 days at both 0.5 and 10 degrees c in uninoculated control oysters (crassostrea virginica). oysters allowed to take up v. vulnificus from seawater retained the bacterium for 14 days at 2 degrees c. the presence of v. vulnificus in the drip exuded from the shell ...	1989	2619304
[immunologic reactivity in patients with gastroduodenal ulcers].	immune system factors were studied in 158 patients with ulcer disease of the stomach and duodenum before and after different operative procedures. more pronounced alterations of immune reactivity as compared with the parameters in patients with noncomplicated ulcer disease were found which manifested themselves in decreased indices of cell immunity, activation of processes of autoallergization, inhibition of nonspecific factors of defense.	2009	2617780
septicaemia due to vibrio vulnificus.		1989	2617638
use of high-pass filtering to detect late potentials in the signal-averaged ecg.	the authors investigate the use of digital filters for analysis of the signal-averaged ecg. they consider the basic types of digital filters and examine respective advantages and disadvantages for ecg analysis. an approach to analyzing the signal-averaged ecg using separate filters for measuring qrs offset and amplitudes is proposed. a study of 19 subjects explores the use of filters to detect low-level activity anywhere in the qrs complex.	2008	2614317
[clinical study of osteoporosis].		2008	2614196
susceptibility of erythrocytes from several animal species to vibrio vulnificus hemolysin.	the hemolytic activity of vibrio vulnificus hemolysin (vvh) against erythrocytes from several animal species (sheep, horse, cow, rabbit, chicken) was investigated. vvh was active against erythrocytes from all species, but the amount of vvh causing 50% hemolysis under identical conditions (hemolytic susceptibility to vvh) differed. the degree of 125i-labeled vvh (125i-vvh) binding to each erythrocyte species correlated with the susceptibility of the cells to hemolysis. however, marked differences ...	1989	2612874
nasal mucosal temperature and the effect of acute infective rhinitis.	nasal mucosal temperature was measured in 71 healthy subjects with an electronic thermometer. no correlation was found between the nasal mucosal temperature and age or sex. an increased mucosal temperature was found in patients with acute rhinitis, an effect which is supposed to assist in the defence system against microorganisms. when measuring nasal mucosal temperature over a 7-h period at the same time as nasal airway resistance, there was no correlation between these factors, indicating that ...	2008	2612033
reflex sympathetic imbalance. response to epidural blockade.	eleven patients (two male, nine female) were treated with epidural sympathetic blockade for reflex sympathetic imbalance, an incomplete manifestation of reflex sympathetic dystrophy. each had developed severe pain, sensitivity, and disability disproportionate to associated trauma. one patient injured an ankle, and the remaining 10 patients one or both knees (12 knees). seven patients had undergone previous surgery. all but one had a favorable response to initial blockade. this individual eventua ...	2008	2610282
management of the temporomandibular joint surgical patient.	comprehensive management of the temporomandibular joint surgical patient necessitates a thorough presurgical evaluation and definitive postsurgical management. the article provides an overview of tmj surgical techniques, including arthroscopy, which has significantly decreased the need for open joint procedures. early postsurgical intervention is recommended and specific therapeutic paradigms are outlined. adjunctive technique to reduce inflammation, muscle guarding, edema, and collagen bonding ...	2008	2605859
solving problems: down the yellow brick road.		2008	2600651
[macular disorders and carotid digital angiography].		2008	2590966
american academy of pediatrics: prep statement.		2008	2587145
[a case of posttraumatic cerebral air embolism].	we report a case of cerebral air embolism that occurred after chest trauma. the diagnosis was confirmed by ct and skull roentgenogram which demonstrated air bubbles in intracranial arteries. it is well recognized that cerebral air embolism is caused by various diagnostic and therapeutic procedures, and trauma. but it may often be overlooked because it is diagnosed clinically and there are no characteristic symptoms nor signs. although various ways of treatment have been reported, prevention and ...	2008	2586716
pathological analyses on the compressed cord by the experimental spinal metastasis.	the purpose of the present experimental spinal metastasis developed in rats by inoculation of walker's cancer cells through the spinous process is to find the factor which causes the initial damage of the cord in this disorder. in the early stage of paralysis, microangiogram exhibited that the degenerated posterior funiculus originated from the small hemorrhagic area in the posterior column of the involved cord. scanning electron microscopic findings showed that the hemorrhage was of the intrins ...	1989	2586714
[the experience of severe complication in the surgical treatment of chronic subdural hematoma: the usefulness of the burr hole and continuous closed system drainage].	seventy-four cases of chronic subdural hematoma were treated by burr hole with irrigation (31 cases), and burr hole and closed system drainage with slow decompression (43 cases). the postoperative changes of the clinical symptoms and ct findings in both groups were compared. markwalder's clinical grading was used for evaluating the clinical symptoms. preoperative grade distribution was as follows, 16 cases in grade 1, 12 cases in grade 2, 3 cases in grade 3 and no case in grade 4 in the irrigati ...	2008	2586712
ultrastructure of the tail of echinostoma revolutum cercaria.	the ultrastructure of the tail fins and muscles of echinostoma revolutum cercaria is described. the longitudinal muscles consist of a primitive type of transversely striated muscle fibres with a well-developed sarcoplasmic reticulum in the z-band. the fins are formed by a longitudinal tegument fold containing the same components as the remaining part of the tail tegument. the difference between the body and tail tegument is discussed.	1989	2583613
[the gynecology clinic in the era of electronic data processing].		2008	2583592
[serologic studies of listeriosis antibodies in dogs in greece].	in an epidemiological study of dogs carried out in greece, antibodies against listeriosis were demonstrated in the slow-agglutination and the complement-fixation-reaction. depending on the dogs' place of origin cfr titers were found in 6.1% to 51.1%. cfr-titers could be confirmed in a comparative investigation with the slow-agglutination-test.	1989	2583499
endodermal sinus tumor and embryonal carcinoma of the ovary in children.	the clinicopathological features of 26 pure endodermal sinus tumors (est) and for embryonal carcinomas of the ovary occurring in children under age 15 years in britain over the period 1962-1978 are described. endodermal sinus tumor has shown a significant increase (p less than 0.001) over the 17-year period considered. compared to controls, est and embryonal carcinoma have not shown an association with the use of hormones or tranquilizers during pregnancy, with radiological investigations, or wi ...	2008	2580758
intestinal infection with mycobacterium avium in acquired immune deficiency syndrome (aids). histological and clinical comparison with whipple's disease.	at endoscopy, a 30-year-old man with acquired immune deficiency syndrome (aids), kaposi's sarcoma, diarrhea, and unexplained malabsorption showed erythematous macular duodenal lesions consistent with whipple's disease by histology and electron microscopy. symptoms did not respond to tetracycline. subsequent cultures revealed systemic mycobacterium avium (m. avium) infection. tissue from this patient, from patients with whipple's disease and from a macaque with m. avium were compared. all contain ...	1985	2580679
relation of capsular materials and colony opacity to virulence of vibrio vulnificus.	colonies which varied in opacity were isolated from the four strains of vibrio vulnificus. opaque and translucent colonial types of the strains were distinguished from the corresponding parent strains. variation in the opacity of colonies formed by each strain was accompanied by variation of capsular material formation, which was clarified by electron microscopy of the organisms stained with ruthenium red. the opaque-type colonies of the strains had capsular materials. on the other hand, three t ...	1985	2578434
characterization of rat cerebral cortical beta adrenoceptor subtypes using (-)-[125i]-iodocyanopindolol.	(-)-[125i]-iodocyanopindolol [-)icyp), used to characterize beta adrenoceptors on membrane preparations from rat cerebral cortex, was shown to have affinity for both beta adrenoceptors and serotonin receptors. therefore, 10 microm serotonin was added to the assays to prevent (-)icyp binding to serotonin receptors. under these conditions, (-)icyp binding to the cortical membrane preparation was reversible and saturable, and the association reaction was very slow. the dissociation reaction was als ...	1989	2577008
[results of synovectomy of the elbow joint in chronic polyarthritis].		2008	2576709
hydrogen peroxide mutagenicity towards salmonella typhimurium.	in bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (ames test) agar plate incorporation bioassay with salmonella typhimurium strains ta97, ta98, ta102, and ta1537, in a 20 min preincubation test with strains ta97, ta98, ta100, ta102, ta1537, and ta1538, and in a liquid incubation modification using strain ta1537. these results conclusively demonstrate that hydrogen peroxide is a weak mutagen, espe ...	1989	2572065
panic attacks, buspirone, and serotonin function.		2008	2570299
recombinant human erythropoietin treatment in patients on maintenance home haemodialysis.		1989	2570273
detection of piluslike structures on clinical and environmental isolates of vibrio vulnificus.	twenty clinical isolates of vibrio vulnificus were compared with 10 environmental strains by using electron microscopy and agglutination assays with human erythrocytes, guinea pig erythrocytes, and saccharomyces cerevisiae. in addition, the isolates were tested for ability to adhere to the human epithelial cell lines hep-2 and a549. when examined by electron microscopy, 16 (80%) of the 20 clinical isolates demonstrated the presence of piluslike structures; the composition of the bacterial popula ...	1989	2568368
effects of toxin isolated from the sea anemone bolocera tuediae on electrical properties of isolated rat skeletal muscle and cultured myotubes.	electrophysiological effects of a polypeptide toxin isolated from the sea anemone bolocera tuediae (bttx ii) on isolated fast and slow rat skeletal muscle and on cultured rat myotubes are described in this paper. nanomolar concentrations of bttx ii cause a concentration-dependent depolarization. this effect is prevented by the presence of tetrodotoxin. action potential duration is prolonged in all preparations investigated, with the fast muscle being the least sensitive. the positive overshoot a ...	1989	2566207
in-vivo effects of (e)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine (mdl 72145) on amine oxidase activities in the rat. selective inhibition of semicarbazide-sensitive amine oxidase in vascular and brown adipose tissues.	one hour after mdl 72145 ((e)-2-(3',4'-dimethoxyphenyl)-3-fluoroallylamine) (2.5 mg kg-1) was given by intraperitoneal injection, the semicarbazide-sensitive amine oxidase (ssao) activity of rat aorta and brown adipose tissue measured in-vitro was reduced by more than 95% of its control value, whereas the monoamine oxidase (mao-a) activity remained virtually unaffected. the action of this drug on amine oxidases in the liver at this dose was less selective. the in-vitro effect of mdl 72145 on the ...	1989	2565962
effect of psoralens and ultraviolet radiation on murine dendritic epidermal cells.	monofunctional psoralens produce less phototoxicity than bifunctional psoralens after ultraviolet a (uva) irradiation. we investigated the effect of repetitive treatments with angelicin (isopsoralen), a monofunctional psoralen, plus uva radiation (ipuva) on the number and morphology of dendritic epidermal cells (dec). this effect was compared with that of 8-methoxypsoralen plus uva radiation (puva), uva alone, and uvb radiation. c3h/hen mice were treated topically with the drugs three times/wk f ...	2008	2565931
comments on radiation-induced g2 arrest in mouse zygotes.		1989	2564879
subdural empyema complicating frontal and ethmoid sinusitis.		2006	2564381
a 3-year evaluation of the tcu380ag and the cu-7.	the tcu380ag and the cu-7 intrauterine devices (iuds) were evaluated in a randomized comparative clinical trial. a total of 198 women who had not recently been pregnant entered the trial in manila, philippines and were followed-up through 3 years postinsertion. the 36-month follow-up rates were impressively high at 80.3 for tcu 380a users and 76.7 for users of the cu-7. although the two iuds demonstrated statistically similar termination rates, the findings suggest a higher efficacy for the tcu3 ...	2006	2564357
a role of carbohydrate-carbohydrate interaction in the process of specific cell recognition during embryogenesis and organogenesis: a preliminary note.	a possible role of cell surface glycoconjugates in cell recognition has been envisioned based on recognition of carbohydrates by cell surface proteins such as endogenous lectins, glycosyltransferases, and hydrolases (refs. 18-22 in text). a new possibility that a specific carbohydrate at the cell surface could be recognized by the same or similar carbohydrate on the counterpart cell surface is now suggested by specific interaction between lex and lex, but not between lex and sialylated or non-su ...	2006	2563943
diversity of glucose entry routes in the enterobacteriaceae.		2008	2561261
[acute maternal anterior poliomyelitis in a non-endemic zone].	the authors report the case of a 26 year old woman with acute anterior poliomyelitis contracted during the vaccination of her baby. despite having been herself vaccinated in infancy she was not protected against the poliovirus. the clinical interest of this uncommon case is a severe paralytic state with definitive paraplegia. the authors suggest serologic testing of patients born before 1967 especially if they are at risk of encountering the virus.	1989	2561040
[successful therapy with tegafur and lentinan after tae for hepatocellular carcinoma--a case report].	a 46-year-old male (performance status 1) with hepatocellular carcinoma (hcc), which diffusely involved the anterior segment of the right lobe, occluded the second portal branch and metastased to the left lobe (stage iv-a), was on combined therapy with tae of lipiodol (lpd), mitomycin c (mmc) 10 mg and gelatin sponge at the time of angiography on march 16, 1987. immunochemotherapy with tegafur suppository (teg sp) 1,000 mg/day and ok432 i.m. was performed for one month after tae. instead of ok43 ...	2006	2559131
enzyme polymorphism and clinical variability of diseases: a study of diabetes mellitus.	we investigated possible relations among four common neonatal manifestations of diabetic pregnancy (macrosomia, hypoglycemia, hypocalcemia, jaundice) and four enzyme polymorphisms (pgm1, ada, ak1, acp1 in a sample of infants born of diabetic mothers. the pattern of associations observed between the two sets of variables is consistent with known differences in enzymatic activity within phenotypes of each system, suggesting that low enzymatic activity may have unfavorable effects on fetal developm ...	1989	2556341
autocrine regulation of 1,25-dihydroxycholecalciferol metabolism in myelomonocytic cells.	in this study the effects of vitamin d metabolites on the myelomonocytic precursor cell line u937 have been compared with those of phorbol myristate acetate (pma). pma was used as a cell modulating agent in order to avoid effects of binding of the exogenous vitamin d metabolites receptors within the cell, which would interfere with subsequent measurement of these receptors in studies of the vitamin d3 metabolic pathway. both the active 1,25 dhcc form of vitamin d3 and the inactive 24,25 dhcc met ...	2008	2553587
phrenic involvement in charcot-marie-tooth disease. a pathologic documentation.	a 69-year-old woman diagnosed as having charcot-marie-tooth disease (cmt) for 30 years' duration died of respiratory failure secondary to diaphragmatic weakness. at autopsy, identical neuropathic changes were found in phrenic and other affected somatic peripheral nerves. we conclude that the phrenic nerve may be involved by the neuropathy of at least some forms of cmt.	2008	2553346
binding modes of mammalian hepatic gal/galnac receptors.	mammalian gal/galnac receptors show dramatic preference for three-branched oligosaccharide structures over two- or one-branched counterparts. the spatial arrangement of the gal residues is extremely important for optimal binding. the three terminal gal residues in the best triantennary ligand are about 15-30 a apart, and therefore the sugar-combining sites on the receptor may also have the same geometry. the results obtained with synthetic ligands containing gal or galnac are in agreement with t ...	2008	2551610
hypoxic changes in hippocampal neurons.	1. reversible effects of brief periods of anoxia (replacing 95% o2-5% co2 with 95% n2-5% co2 for 2-4 min) were studied in ca1 neurons in hippocampal slices (from sprague-dawley rats), kept in an interface-type chamber at 33.5 degree. 2. the predominant voltage change during anoxia (n2) was a hyperpolarization, accompanied by a marked fall in resistance and excitability; synaptic potentials were also depressed, especially inhibitory postsynaptic potentials (ipsps). 3. in voltage-current (v-i) plo ...	1989	2547034
sodium and potassium currents recorded during an action potential.	a simple method was used to measure directly sodium and potassium currents underlying the action potential in single nerve fibres of xenopus laevis. a short rectangular stimulus under current-clamp conditions elicited an action potential which was digitally stored and later used as command when voltage-clamping the same fibre. the currents thus obtained nearly reproduced the original rectangular stimulus. adding first 100 nm ttx and subsequently 100 nm ttx plus 10 mm tea to the extracellular rin ...	1989	2546753
a simple colorimetric assay method for pyrophosphate in the presence of a 1000-fold excess of orthophosphate: application of the method to the study of pyrophosphate metabolism in mitochondria.	a sensitive colorimetric method for the assay of inorganic pyrophosphate with excess of orthophosphate is described. the principle of this method lies in the formation of phosphomolybdate and ppi-molybdate complexes with subsequent extraction of the phosphomolybdate complex by organic solvents and reduction of the ppi-molybdate complex by dithiothreitol and eikonogen. the sensitivity of the method was from 5 to 120 nmol of ppi in a 2.0-ml sample.	1989	2545112
bile acid profile in a dog with cholangiocarcinoma.		1989	2536512
suppression.		2008	2533505
cell proliferation kinetics of epidermis, hair follicles, and sebaceous glands of cocker spaniels with idiopathic seborrhea.	cell proliferation kinetic values were established for the epidermis, hair follicle epithelium, and sebaceous glands of 8 cocker spaniels with primary idiopathic seborrhea. values were established by intradermal pulse labeling injections of tritiated thymidine followed by cutaneous biopsy and autoradiography. the epidermal basal cell-labeling index was 4.96 +/- 0.97%, and the epidermal nucleated cell-labeling index was 3.33 +/- 0.71%. calculated epidermal cell renewal time for the viable layers ...	1989	2533468
[short- and medium-term treatment of ventricular hyperkinetic arrhythmia with flecainide].	our study group included 12 patients (4 males, 8 females), mean age 60 yr, with symptomatic or threatening tachyarrhythmias (lown classes iv a, b, v); 2 patients were suffering from mitral valve prolapse syndrome, 2 from ischemic heart disease; 4 from cardiac insufficiency caused by hypertensive or ischemic heart disease; 4 had no evident clinical signs of cardiopathy. patients suffering from: cardiac insufficiency (f.c. iii e iv nyha); ii and iii degree bav; atrial flutter and fibrillation; lon ...	2008	2527112
a simple and inexpensive method for preparing erythrocyte membranes by filtration through a hollow-fiber system.	an efficient, simple method for preparing biologically active erythrocyte membranes is described. the semi-automated procedure involves circulating hemolysate mixture through a hollow-fiber system, thereby filtering off intracellular components leaving a high yield of washed ghosts. the prepared ghosts exhibit cation-stimulated atpase activities comparable to those of ghosts prepared by traditional methods. electron micrographs revealed that the filtration isolation caused less shearing of the m ...	2008	2527009
killing of human tumor cells by antibody c3b conjugates and human complement.	to potentiate the lytic action of complement on tumor cells, we have constructed heteroconjugates composed of monoclonal antibody and of the human c3b component of complement. the conjugates were formed efficiently using the heterobifunctional cross-linking reagent spdp. the monoclonal antibody-c3b conjugate promoted the killing of k562 tumor cells by normal human serum. treatment of the tumor cells with the monoclonal antibody and normal human serum resulted in 10-15% lysis. however, following ...	1989	2519543
the biology of the scid mutation.		2008	2519515
[cardiac tamponade as the first manifestation of cancer].	we report 3 patients having cardiac tamponade as the initial presentation of cancer. at the onset of symptoms all three patients were incorrectly diagnosed. pulsus paradoxus and cardiomegaly on the chest x-ray were the main clinical features. two dimensional echocardiography was vital revealing massive pericardial effusion with diastolic right atrial and ventricular collapse. all patients had bloody pericardial fluid removed and the histopathology of the metastatic pericardial tissue showed lung ...	2008	2519419
[nuclear magnetic resonance in the diagnosis of multiple sclerosis. a critical review of the literature].	nuclear magnetic resonance (nmr) has been proposed to be the best diagnostic test for multiple sclerosis (ms). we performed a critical analysis of 13 papers evaluating the use of nmr in ms. out of an ideal 17 criteria for validation and reproducibility, a top of 11 (65%) was the maximum found. foremost deficiencies were a lack of blind analysis and inadequate patient samples. thus the claim that nmr is the diagnostic tool of choice in ms remains to be proven.	2008	2519356
[two case reports of septic shock due to vibrio vulnificus with liver cirrhosis].	we have recently experienced a case of vibrio vulnificus septicemia which occurred in a patient with hepatic cirrhosis, and as we were able to give early antibiotic treatment, the patient survived. we would like to report this case here together with another case experienced 2 years ago. case 1 was a 58-year-old male who was attending our hospital as an outpatient for hepatic cirrhosis. at 5:30 pm on august 8, 1987, he consumed abalone and giant clam and at 9 pm complained of high fever with sha ...	1989	2501432