Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| advanced methods for dose and regimen finding during drug development: summary of the ema/efpia workshop on dose finding (london 4-5 december 2014). | inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of late-stage attritions in clinical development and postmarketing commitments required by regulatory institutions. in an effort to shift the current paradigm in dose and regimen selection and highlight the availability and usefulness of well-established and regulatory-acceptable methods, the european medicines agency (ema) in collaboration wit ... | 2017 | 28722322 |
| table saw injuries: are our safety features really keeping us safe? | currently, table saws sold in the united states have 3 safety features (riving knife, blade guard, and antikickback device) designed to prevent personal injury; however, these features can hinder the user's movements and are often disabled or removed. despite the frequency of table saw injuries, there is relatively limited literature regarding them. | 2017 | 28719989 |
| establishing obstetric anesthesiology practice guidelines in the republic of armenia: a global health collaboration. | disparity exists in anesthesia practices between high- and low-to-middle income countries, and awareness has been raised within the global health community to improve the standards of anesthesia care and patient safety. the establishment of international collaborations and appropriate practice guidelines may help address clinical care deficiencies. this report's aim was to assess the impact of a multiyear collaboration on obstetric anesthesia practices in the republic of armenia. | 2017 | 28719524 |
| comparison of the effects of low dose interferon and high dose interferon on reduction of the number and size of plaques in patients with multiple sclerosis: a historical cohort. | background: this study was performed to compare the effects of low dose interferon beta-1 (ifn-β-1) (cinnovex, 30 mcg) and high dose ifn-β-1 (rebif, 44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods: this historical cohort study, which was performed in 2014 in sanandaj (western part of iran). 43 ms patients in two groups were investigated. the first group, which included 19 patients, was treated using ... | 2017 | 28717427 |
| contrast-induced nephropathy in urological imaging: a comparison with cardiology interventions. | published studies about contrast-induced nephropathy (cin) mainly focus on cardiac intervention and rarely focus on patients undergoing urological contrast investigations. we aimed to determine the association and effect of intravenous (iv) iodinated contrast material on the incidence of cin in a group of patients undergoing urology investigation and compare the results with that of cardiology interventions. | 2017 | 28717277 |
| factors associated with rerupture of intracranial aneurysms after endovascular treatment: a retrospective review of 11years experience at a single institution and review of the literature. | aneurysm rebleeding following initial endovascular management is uncommon, and the factors associated with its occurrence are poorly defined. we retrospectively analyzed a consecutive series of patients presenting with aneurysmal subarachnoid hemorrhage who underwent endovascular management to determine factors associated with rebleeding. rebleeding occurred in 7/183 (3.8%) patients, 6 of which had an adjacent hematoma on initial neuroimaging. aneurysms were located on the acoa (n=5), pcoa (n=1) ... | 2017 | 28716568 |
| clinical and radiologic predictive factors of rib fractures in outpatients with chest pain. | to identify the clinical and radiologic predictive factors of rib fractures in stable adult outpatients presenting with chest pain and to determine the utility of dedicated rib radiographs in this population of patients. | 2017 | 28716296 |
| the use of non-uniform drowning terminology: a follow-up study. | in 2002, the world congress on drowning developed a uniform definition for drowning. the aim of this study is to determine the prevalence of "non-uniform drowning terminology" (nudt) and "non-uniform drowning definitions" (nudd) in peer-reviewed scientific literature from 2010 to 2016, and compare these findings with those from our unpublished study performing a similar analysis on literature from 2003 to 2010. | 2017 | 28716063 |
| no adverse lung effects of 7- and 28-day inhalation exposure of rats to emissions from petrodiesel fuel containing 20% rapeseed methyl esters (b20) with and without particulate filter - the fuelhealth project. | increased use of biofuels raises concerns about health effects of new emissions. we analyzed relative lung health effects, on fisher 344 rats, of diesel engine exhausts emissions (dee) from a euro 5-classified diesel engine running on petrodiesel fuel containing 20% rapeseed methyl esters (b20) with and without diesel particulate filter (dpf). one group of animals was exposed to dee for 7 days (6 h/day), and another group for 28 days (6 h/day, 5 days/week), both with and without dpf. the animals ... | 2017 | 28714748 |
| safety and efficacy of rivaroxaban compared with warfarin in patients undergoing peripheral arterial procedures. | rivaroxaban is a united states food and drug administration-approved oral anticoagulant for venous thromboembolic disease; however, there is no information regarding the safety and its efficacy to support its use in patients after open or endovascular arterial interventions. we report the safety and efficacy of rivaroxaban vs warfarin in patients undergoing peripheral arterial interventions. | 2017 | 28712814 |
| clinical presentation to the emergency department predicts subarachnoid hemorrhage-associated myocardial injury. | aneurysmal subarachnoid hemorrhage (asah) is frequently seen in emergency departments. secondary injury, such as subarachnoid hemorrhage-associated myocardial injury (sahmi), affects one third of survivors and contributes to poor outcomes. sahmi is not attributed to ischemia from myocardial disease but can result in hypotension and arrhythmias. it is important that emergency nurses recognize which clinical presentation characteristics are predictive of sahmi to initiate proper interventions. the ... | 2017 | 28712527 |
| service quality of diagnostic fine needle aspiration cytology in a tertiary care hospital of lahore (process measure as patient's perspective). | quality of any service is the most important aspect for the manufacturer as well as the consumer. the primary objective of any nation's health system is to provide supreme quality health care services to its patients. the objective of this study was to assess the quality of diagnostic fine needle aspiration cytology service in a tertiary care hospital. as patient's perspectives provide valuable information on quality of process, therefore, patient's perception in terms of satisfaction with the s ... | 2017 | 28712184 |
| cerebral vasospasm-dependent and cerebral vasospasm-independent cerebral infarctions predict outcome after nonaneurysmal subarachnoid hemorrhage: a single-center series with 250 patients. | the number of patients with nonaneurysmal subarachnoid hemorrhage (nasah) has increased during the last decade. data regarding infarctions in nasah are still limited. the aim of this study was to identify the rate of cerebral vasospasm (cvs)-dependent and cvs-independent infarctions and their influence on clinical outcomes. | 2017 | 28711533 |
| size of facial port-wine birthmark may predict neurologic outcome in sturge-weber syndrome. | to determine whether the size of the birthmark in patients with sturge-weber syndrome (sws) who have brain involvement can help predict neurologic disability. | 2017 | 28711177 |
| threatened fish and fishers along the brazilian atlantic forest coast. | small-scale fisheries of the brazilian atlantic forest coast (bafc) depend on fish resources for food and income. thus, if the catch diminishes or if fish species that are a target for fishers are overexploited or impacted, this could affect fishers' livelihoods. the exclusion of threatened fish species from the catch is believed to be a threat to small-scale fisheries, which is likely to be the case along the bafc. many fish species are currently listed as threatened or vulnerable, whereas ther ... | 2017 | 28710567 |
| deep learning based radiomics (dlr) and its usage in noninvasive idh1 prediction for low grade glioma. | deep learning-based radiomics (dlr) was developed to extract deep information from multiple modalities of magnetic resonance (mr) images. the performance of dlr for predicting the mutation status of isocitrate dehydrogenase 1 (idh1) was validated in a dataset of 151 patients with low-grade glioma. a modified convolutional neural network (cnn) structure with 6 convolutional layers and a fully connected layer with 4096 neurons was used to segment tumors. instead of calculating image features from ... | 2017 | 28710497 |
| microrna-9 regulates fetal alcohol-induced changes in d2 receptor to promote prolactin production. | fetal alcohol exposure (fae) is known to increase prolactin (prl) secretion from the pituitary lactotropes. in this study, we determined whether micrornas (mirs) are involved in fae-induced alteration in prl release. we employed a rat animal model of fae involving feeding pregnant fisher 344 rats with a liquid diet containing 6.7% alcohol between gestational days 7-21 (af). both cyclic and estradiol-implanted fae females showed increased levels of plasma prl and pituitary prl mrna but reduced le ... | 2017 | 28710248 |
| crossing fitness canyons by a finite population. | we consider the wright-fisher model of the finite population evolution on a fitness landscape defined in the sequence space by a path of nearly neutral mutations. we study a specific structure of the fitness landscape: one of the intermediate mutations on the mutation path results in either a large fitness value (climbing up a fitness hill) or a low fitness value (crossing a fitness canyon), the rest of the mutations besides the last one are neutral, and the last sequence has much higher fitness ... | 2017 | 28709354 |
| t2*-weighted and diffusion magnetic resonance imaging differentiation of cerebral fat embolism from diffuse axonal injury. | this study differentiates cerebral fat embolism (cfe) and diffuse axonal injury (dai) on diffusion-weighted magnetic resonance imaging (dwi) and t2*-weighted magnetic resonance imaging. | 2017 | 28708729 |
| effects of image quality on the fundamental limits of image registration accuracy. | for image-guided procedures, the imaging task is often tied to the registration of intraoperative and preoperative images to a common coordinate system. while the accuracy of this registration is a vital factor in system performance, there is relatively little work that relates registration accuracy to image quality factors such as dose, noise, and spatial resolution. to create a theoretical model for such a relationship, we present a fisher information approach to analyze registration performan ... | 2017 | 28708549 |
| workup for perinatal stroke does not predict recurrence. | perinatal stroke, including neonatal and presumed perinatal presentation, represents the age in childhood in which stroke occurs most frequently. the roles of thrombophilia, arteriopathy, and cardiac anomalies in perinatal ischemic stroke are currently unclear. we took a uniform approach to perinatal ischemic stroke evaluation to study these risk factors and their association with recurrent stroke. | 2017 | 28706112 |
| miniaturized radiochemical purity testing for (99m)tc-hmpao, (99m)tc-hmdp, and (99m)tc-tetrofosmin. | quick methods are functional in clinical practice to ensure the fastest availability of radiopharmaceuticals. for this purpose, we investigated the radiochemical purity of the widely used (99m)tc-hydroxymethylene diphosphonate, (99m)tc-hexamethylpropyleneamine oxime, and (99m)tc-tetrofosmin by reducing time as compared with the manufacturer's method. methods: we applied a miniaturized chromatographic method with a reduced strip development from 18 cm to 9 cm for all 3 radiopharmaceuticals. the s ... | 2017 | 28705928 |
| primary cystic lesions of the retrorectal space: mri evaluation and clinical assessment. | the purpose of this study was to assess the a priori chance that primary cystic lesions of the retrorectal space are malignant and to investigate mri characteristics that indicate malignancy. | 2017 | 28705066 |
| safety concerns regarding article: reliability and validity of a self-paced cardiopulmonary exercise test in post-mi patients. l. a. jenkins, a. mauger, j. fisher, j. hopker. int j sports med 2017; 38: 300-306. | 2017 | 28704877 | |
| low end-tidal carbon dioxide at the onset of emergent trauma surgery is associated with nonsurvival: a case series. | end-tidal carbon dioxide (etco2) is a valuable marker of the return of adequate circulation following cardiac arrest due to medical causes. previously, the prognostic value of capnography in trauma has been studied among limited populations in prehospital and emergency department settings. we aimed to investigate the relationship between early intraoperative etco2 and nonsurvival of patients undergoing emergency surgery at a level 1 academic trauma center as a case series. if there is a threshol ... | 2017 | 28704248 |
| measurement of absolute copy number variation of glutathione s-transferase m1 gene by digital droplet pcr and association analysis in tunisian rheumatoid arthritis population. | the investigation of copy number variations (cnvs) analysis of candidate genes is currently an important research area in modulating human diseases. we aimed to quantify cnvs in glutathione s-transferase m1 (gstm1) gene and determine its genetic contribution in tunisian rheumatoid arthritis (ra) and its subsets through an innovative technique for quantification. | 2017 | 28703442 |
| megakaryocytic morphology in janus kinase 2 v617f positive myeloproliferative neoplasm. | alterations in megakaryocyte morphology are the hallmark of myeloproliferative neoplasms (mpns). these neoplasm are also associated with janus kinase 2 (jak2) v617f mutation in nearly 95% patients with polycythemia vera (pv), 40% patients of essential thrombocythemia (et) and 50% patients of myelofibrosis (mf). the utility of megakaryocyte morphology in these disorders in correlation with jak2 v617f remains unresolved. | 2017 | 28702412 |
| genotype by random environmental interactions gives an advantage to non-favored minor alleles. | fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. here we use a number of models (several versions of the moran model and the haploid wright-fisher model) to examine fixation probabilities for a constant size population where the fitness is a random function of both allelic state and spatial position, despite neither allele being favored on average. the concept of f ... | 2017 | 28701726 |
| medical image classification via multiscale representation learning. | multiscale structure is an essential attribute of natural images. similarly, there exist scaling phenomena in medical images, and therefore a wide range of observation scales would be useful for medical imaging measurements. the present work proposes a multiscale representation learning method via sparse autoencoder networks to capture the intrinsic scales in medical images for the classification task. we obtain the multiscale feature detectors by the sparse autoencoders with different receptive ... | 2017 | 28701276 |
| what can we do to reduce the associated costs in induction of labour of intrauterine growth restriction foetuses at term? a cost-analysis study. | to evaluate the costs associated with induction of labour in intrauterine growth restriction fetuses comparing different procedures. | 2017 | 28698953 |
| the earth is flat (p > 0.05): significance thresholds and the crisis of unreplicable research. | the widespread use of 'statistical significance' as a license for making a claim of a scientific finding leads to considerable distortion of the scientific process (according to the american statistical association). we review why degrading p-values into 'significant' and 'nonsignificant' contributes to making studies irreproducible, or to making them seem irreproducible. a major problem is that we tend to take small p-values at face value, but mistrust results with larger p-values. in either ca ... | 2017 | 28698825 |
| a randomized crossover trial comparing patient preference for mandibular complete dentures made with two different techniques: a short-term follow-up. | the objective of this trial was to compare short-term patient preference for two mandibular complete denture (cd) fabrication techniques: neutral zone (nz) and conventional (cv). | 2017 | 28697202 |
| a general protocol of ultra-high resolution mr angiography to image the cerebro-vasculature in 6 different rats strains at high field. | differences in the cerebro-vasculature among strains as well as individual animals might explain variability in animal models and thus, a non-invasive method tailored to image cerebral vessel of interest with high signal to noise ratio is required. | 2017 | 28694213 |
| house ownership, frequency of illness, fathers' education: the most significant socio-demographic determinants of poor nutritional status in adolescent girls from low income households of lahore, pakistan. | socio demographic factors besides dietary factors play important role in determining the health status of an individual. health and nutritional intervention programs stand a greater chance of success if planned, keeping the socio demographic characteristics of a certain population in focus. the present study was conducted to identify those socio demographic determinants which have a significant association with poor nutritional status in adolescent girls belonging to economically deprived househ ... | 2017 | 28693602 |
| the prognosis factors for endovascular coiling of aneurysm in patients with ruptured intracranial aneurysm. | the spontaneous subarachnoid hemorrhage caused by aneurysm rupture often leads to a variety of complications. endovascular coiling is effective in the treatment of ruptured intracranial aneurysm. | 2017 | 28692523 |
| design and applications of metastable-state photoacids. | proton transfer is one of the most common processes in nature, and many chemical, material, and biological processes are sensitive to proton concentration, from acid-catalyzed reactions to the activities of many enzymes. photoacids that reversibly undergo proton dissociation upon irradiation promise remote spatial and temporal control over proton-sensitive processes and could provide a way to convert photoenergy into other types of energy. the recently discovered metastable-state photoacids can ... | 2017 | 28692282 |
| aromaticity and antiaromaticity of substituted fulvene derivatives: perspectives from the information-theoretic approach in density functional reactivity theory. | even though the concept of aromaticity and antiaromaticity is extremely important and widely used, there still exist lots of controversies in the literature, which are believed to be originated from the fact that there are so many aromatic types discovered and at the same time there are many aromaticity indexes proposed. in this work, using seven series of substituted fulvene derivatives as an example and with the information-theoretic approach in density functional reactivity theory, we examine ... | 2017 | 28692080 |
| use of 23.4% saline in symptomatic vasospasm and cushing's triad to prevent herniation and death: a case report. | a 53-year-old woman with migraines presented with hunt-hess grade 5 and fisher grade 4 subarachnoid hemorrhage with intraventricular hemorrhage. she experienced severe vasospasm requiring intra-arterial medications. continued vasospasm and edema resulted in cushing's triad with profound tachypnea. three percentage saline was administered twice without improvement. despite the general practice to wait until complete neurologic deterioration before administering 23.4% saline, it was administered o ... | 2017 | 28691981 |
| polymorphism of the pai-1gene (4g/5g) may be linked with polycystic ovary syndrome and associated pregnancy disorders in south indian women. | polycystic ovary syndrome (pcos) is the most common endocrine disorder affecting 5 - 10% of all women of reproductive age group. the present research was carried out to study the impact of plasminogen activator inhibitor (pai-1) 4g/5g polymorphism (rs1799889) in pcos, and the risk of developing pcos in south indian population. the study was carried out in 60 subjects of south indian population (30 pcos and 30 non pcos) recruited from arc research and fertility centre, chennai, india. genotype an ... | 2017 | 28690381 |
| a 3-year clinical evaluation of endodontically treated posterior teeth restored with two different materials using the cerec ac chair-side system. | the introduction of polymer-infiltrated ceramic network (picn) materials may provide more options for dentists in restoring short clinical crowns and extensively damaged posterior teeth, but clinical data for their performance are lacking. | 2017 | 28689915 |
| arthroscopic versus open rotator cuff repair: which has a better complication and 30-day readmission profile? | to provide a comparative 30-day postoperative analysis of complications and unplanned readmission rates, using the national surgical quality improvement program database, after open or arthroscopic rotator cuff repair (rcr). | 2017 | 28688827 |
| effect of the addition of cetuximab to paclitaxel, cisplatin, and radiation therapy for patients with esophageal cancer: the nrg oncology rtog 0436 phase 3 randomized clinical trial. | the role of epidermal growth factor receptor (egfr) inhibition in chemoradation strategies in the nonoperative treatment of patients with esophageal cancer remains uncertain. | 2017 | 28687830 |
| deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain. | as a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. here, we show that deguelin, a plant-derived rotenoid, selectively and potently inhibits the motility and development of nematodes, which supports its potential as a lead candidate for drug development. furthermore, we demonstrate that deguelin treatment significantly increases gene transcription that is associ ... | 2017 | 28687609 |
| genetic risk factors for myocardial infarction more clearly manifest for early age of first onset. | epidemiological genetics established that heritability in determining the risk of myocardial infarction (mi) is substantially greater when mi occurs early in life. however, the genetic architecture of early-onset and late-onset mi was not compared. we analyzed genotype frequencies of snps in/near 20 genes whose protein products are involved in the pathogenesis of atherosclerosis in two groups of russian patients with mi: the first group included patients with age of first mi onset <60 years (n = ... | 2017 | 28685248 |
| single nucleotide variant sequencing errors in whole exome sequencing using the ion proton system. | errors in sequencing are a major obstacle in the interpretation of next-generation sequencing (ngs) results. in the present study, sequencing errors identified from analysis of single nucleotide variants (snvs) identified during exome sequencing of human germline dna were studied using the thermo fisher ion proton system. two consanguineous cases were selected for sequencing using the ampliseq exome capture kit, and snvs found in both cases were validated using sanger sequencing. a total of 98 s ... | 2017 | 28685054 |
| efficiency of rate and latency coding with respect to metabolic cost and time. | recent studies on the theoretical performance of latency and rate code in single neurons have revealed that the ultimate accuracy is affected in a nontrivial way by aspects such as the level of spontaneous activity of presynaptic neurons, amount of neuronal noise or the duration of the time window used to determine the firing rate. this study explores how the optimal decoding performance and the corresponding conditions change when the energy expenditure of a neuron in order to spike and maintai ... | 2017 | 28684283 |
| filling the gap: using fishers' knowledge to map the extent and intensity of fishing activity. | knowledge of the extent and intensity of fishing activities is critical to inform management in relation to fishing impacts on marine conservation features. such information can also provide insight into the potential socio-economic impacts of closures (or other restrictions) of fishing grounds that could occur through the future designation of marine conservation zones (mczs). we assessed the accuracy and validity of fishing effort data (spatial extent and relative effort) obtained from fishers ... | 2017 | 28683931 |
| comparison of b-mode with b-flow sonography for the evaluation of femoral arteries in infants. | purpose to evaluate femoral arteries (fas) in infants in the context of catheter angiography with b-mode (bms) and b-flow sonography (bfs) and to compare both methods for vessel delineation and reliability of vessel diameter measurements. methods 21 consecutive infants who underwent ultrasound for the evaluation of fas before or after cardiac catheterization were retrospectively included in this study. the diameter of the fas and the maximum length of the vessel section displayed on a single ult ... | 2017 | 28683505 |
| can we differentiate minimally invasive adenocarcinoma and non-invasive neoplasms based on high-resolution computed tomography features of pure ground glass nodules? | the purpose of our study was to assess the differentially diagnostic value of radiographic characteristics of pure ground glass nodules (ggns) between minimally invasive adenocarcinoma and non-invasive neoplasm. | 2017 | 28683126 |
| socioeconomic and racial/ethnic disparities in physical activity environments in georgia elementary schools. | this study aimed to characterize physical activity (pa) environments in georgia public elementary schools and to identify socioeconomic status (ses) and racial/ethnic disparities in pa environments. | 2017 | 28682137 |
| comprehensive chemical fingerprinting of high-quality cocoa at early stages of processing: effectiveness of combined untargeted and targeted approaches for classification and discrimination. | this study investigates chemical information of volatile fractions of high-quality cocoa (theobroma cacao l. malvaceae) from different origins (mexico, ecuador, venezuela, columbia, java, trinidad, and sao tomè) produced for fine chocolate. this study explores the evolution of the entire pattern of volatiles in relation to cocoa processing (raw, roasted, steamed, and ground beans). advanced chemical fingerprinting (e.g., combined untargeted and targeted fingerprinting) with comprehensive two-dim ... | 2017 | 28682071 |
| the effect of sensory level electrical stimulation of the masseter muscle in early stroke patients with dysphagia: a randomized controlled study. | dysphagia is a serious cause of morbidity and mortality in stroke patients. | 2017 | 28681742 |
| association between weight change, health outcomes, and mortality in older residents in long-term care. | despite the numerous health risks associated with being overweight, the effect of weight loss on health and longevity remains controversial, particularly in older adults. we explored the association among weight changes, health outcomes, and mortality in older residents of a skilled nursing facility. | 2017 | 28679015 |
| clinical and incidental perineural invasion of cutaneous squamous cell carcinoma: a systematic review and pooled analysis of outcomes data. | perineural invasion (pni) in cutaneous squamous cell carcinoma (cscc) has been associated with an increased risk of poor outcomes. patients with pni may present with clinical symptoms and/or radiologic evidence of pni (clinical pni [cpni]), yet most patients are asymptomatic and pni is often found on histologic examination (incidental pni [ipni]). evidence-based estimates of the risks of disease-related outcomes comparing ipni and cpni are limited in the dermatology literature. | 2017 | 28678985 |
| assessment of the responsiveness of a public health service from the perspective of older adults. | to assess the quality of health care of older adults using as a parameter the assessment of the responsiveness of the service. | 2017 | 28678911 |
| redistribution of benefits but not defection in a fisheries bycatch-reduction management initiative. | reducing the capture of small fish, discards, and by-catch is a primary concern of fisheries mangers that propose to maintain high yields, species diversity, and associated ecosystem functions. modified fishing gear is one of the primary ways to reduce by-catch and capture of small fish. the outcomes of gear modification may depend on competition with other gears using similar fishing grounds and resources and the subsequent adoption or defection of fishers using modified gears. we evaluated the ... | 2017 | 28678422 |
| assessing the proposed association between ded and gluten-free diet introduction in celiac children. | a strong association between celiac disease (cd) and dental enamel defects (deds) have been extensively reported, however, the nature of this relationship is still unclear. the aim of this study was to evaluate deds phenotype in cd individuals according to the time they were introduced to a gluten-free diet (gfd). forty-five cd individuals were examined by a pediatric dentist. deds were classified according to the type of affected teeth. cd individuals were classified into two groups (with or wi ... | 2017 | 28677884 |
| usefulness of cytologic criteria in ultrasound-guided fine-needle aspirates from subcentimeter canine mammary tumors. | we determined cytologic features of histologically confirmed subcentimeter canine mammary tumors (cmts) to determine reasonable criteria for an accurate cytologic diagnosis. fifty-three cmts from 28 bitches were included. all cytologic samples were collected by ultrasound-guided fine-needle aspiration biopsy, stained with may-grünwald/giemsa, and retrospectively evaluated using a scoring system established for 18 cytologic features. mean nuclear area (mna) was also measured for each sample by a ... | 2017 | 28677423 |
| application of iterative robust model-based optimal experimental design for the calibration of biocatalytic models. | the aim of model calibration is to estimate unique parameter values from available experimental data, here applied to a biocatalytic process. the traditional approach of first gathering data followed by performing a model calibration is inefficient, since the information gathered during experimentation is not actively used to optimize the experimental design. by applying an iterative robust model-based optimal experimental design, the limited amount of data collected is used to design additional ... | 2017 | 28675693 |
| obstetric brachial plexus injury. knowledge among health care providers in saudi arabia. | to assess the basic knowledge on obstetric brachial plexus injury among obstetricians, pediatricians, and physio-/occupational therapists in major hospitals in riyadh. we aimed to identify if inadequate knowledge is the reason behind delayed referrals to the hand clinic. methods: this is a cross-sectional questionnaire-based study conducted at 5 major hospitals in riyadh, saudi arabia between june 2015 and august 2015. a questionnaire of 6 questions (multiple choice closed-ended questions) wa ... | 2017 | 28674717 |
| partial pulpotomy in mature permanent teeth with clinical signs indicative of irreversible pulpitis: a randomized clinical trial. | this study aimed to assess the outcome of partial pulpotomy using mineral trioxide aggregate (mta) compared with calcium hydroxide (ch) in mature cariously exposed permanent molars. | 2017 | 28673494 |
| does injection flow rate have an impact on arterial phase image degradation in liver mri? a comparison of gadoxetic acid versus gadobutrol. | to evaluate retrospectively the impact of injection flow rate on arterial phase image degradation in liver magnetic resonance imaging (mri) with gadoxetic acid (gd-eob-dtpa) compared to gadobutrol. | 2017 | 28673445 |
| targeting moderate and severe male stress urinary incontinence with adjustable male slings and the perineal artificial urinary sphincter: focus on perioperative complications and device explantations. | to analyze perioperative complications and postoperative explantation rates for selected readjustable male sling systems and the perineal single-cuff artificial urinary sphincter (aus) in a large, contemporary, multi-institutional patient cohort. | 2017 | 28673058 |
| the relationship between high flow nasal cannula flow rate and effort of breathing in children. | to use an objective metric of effort of breathing to determine optimal high flow nasal cannula (hfnc) flow rates in children <3 years of age. | 2017 | 28669609 |
| quantitative contrast-enhanced ct attenuation evaluation of osseous metastases following chemotherapy. | osseous metastases often undergo an osteoblastic healing response following chemotherapy. the purpose of our study was to demonstrate the quantitative ct changes in attenuation of osseous metastases before and after chemotherapy. | 2017 | 28667362 |
| craniospinal irradiation prior to stem cell transplant for hematologic malignancies with cns involvement: effectiveness and toxicity after photon or proton treatment. | craniospinal irradiation (csi) improves local control of leukemia/lymphoma with central nervous system (cns) involvement; however, for adult patients anticipating stem cell transplant (sct), cumulative treatment toxicity is a major concern. we evaluated toxicities and outcomes for patients receiving proton or photon csi before sct. | 2017 | 28666906 |
| flibanserin efficacy and safety in premenopausal women with generalized acquired hypoactive sexual desire disorder. | flibanserin is a postsynaptic 5-ht-1a agonist and 5-ht-2a antagonist for the treatment of generalized acquired hypoactive sexual desire disorder in premenopausal women. | 2017 | 28666836 |
| feasibility and safety of mild therapeutic hypothermia in poor-grade subarachnoid hemorrhage: prospective pilot study. | therapeutic hypothermia (th) improves the neurological outcome in patients after cardiac arrest and neonatal hypoxic brain injury. we studied the safety and feasibility of mild th in patients with poor-grade subarachnoid hemorrhage (sah) after successful treatment. patients were allocated randomly to either the th group (34.5°c) or control group after successful clipping or coil embolization. eleven patients received th for 48 hours followed by 48 hours of slow rewarming. vasospasm, delayed cere ... | 2017 | 28665071 |
| on selection in finite populations. | two major forces shaping evolution are drift and selection. the standard models of neutral drift-the wright-fisher (wf) and moran processes-can be extended to include selection. however, these standard models are not always applicable in practice, and-even without selection-many other drift models make very different predictions. for example, "generalised wright-fisher" models (so-called because their first two conditional moments agree with those of the wf process) can yield wildly different ab ... | 2017 | 28664222 |
| ethanol ablation of ranulas: short-term follow-up results and clinicoradiologic factors for successful outcome. | surgical excision of an affected sublingual gland for treatment of a ranula can carry a potential of a nerve damage or postoperative complications. however, there have been little studies about effective minimally invasive therapeutic method, yet. our aim was to evaluate the efficacy and safety of ethanol ablation of ranulas and the clinicoradiologic factors that can predict outcome. | 2017 | 28663262 |
| representation of multidimensional stimuli: quantifying the most informative stimulus dimension from neural responses. | a common way to assess the function of sensory neurons is to measure the number of spikes produced by individual neurons while systematically varying a given dimension of the stimulus. such measured tuning curves can then be used to quantify the accuracy of the neural representation of the stimulus dimension under study, which can in turn be related to behavioral performance. however, tuning curves often change shape when other dimensions of the stimulus are varied, reflecting the simultaneous s ... | 2017 | 28663198 |
| effect of latitude on vitamin d levels. | vitamin d levels have been linked to bone health and to numerous diseases; however, an element that lacks substantial direct data and limits the evidence basis regarding whom to screen for vitamin d deficiency is the effect of latitude on vitamin d levels. | 2017 | 28662556 |
| clonestimate, a bayesian method for quantifying rates of clonality of populations genotyped at two-time steps. | partial clonality is commonly used in eukaryotes and has large consequences for their evolution and ecology. assessing accurately the relative importance of clonal vs. sexual reproduction matters for studying and managing such species. here, we proposed a bayesian approach, clonestimate, to infer rates of clonality c from populations sampled twice over a short time interval, ideally one generation time. the method relies on the likelihood of the transitions between genotype frequencies of ancest ... | 2017 | 28662317 |
| revisiting the vulnerability of juvenile bigeye (thunnus obesus) and yellowfin (t. albacares) tuna caught by purse-seine fisheries while associating with surface waters and floating objects. | tuna fisheries catch over three million tonnes of skipjack tuna (katsuwonus pelamis) each year, the majority of which come from purse-seine vessels targeting fish associated with man-made fish aggregating devices (fads). a significant challenge for fisheries management is to maximize the efficiency of skipjack tuna catches whilst minimizing the bycatch of small and immature bigeye (thunnus obesus) and yellowfin (t. albacares) tuna, for which long-term sustainability is uncertain in 75% of the wo ... | 2017 | 28662091 |
| individual bayesian information matrix for predicting estimation error and shrinkage of individual parameters accounting for data below the limit of quantification. | in mixed models, the relative standard errors (rse) and shrinkage of individual parameters can be predicted from the individual bayesian information matrix (mbf). we proposed an approach accounting for data below the limit of quantification (loq) in mbf. | 2017 | 28660401 |
| serum albumin level in spontaneous subarachnoid haemorrhage: more than a mere nutritional marker! | the role of nutritional markers on outcome following subarachnoid hemorrhage (sah) has been scarcely described. | 2017 | 28658989 |
| prevalence and factors associated with human brucellosis in livestock professionals. | the objective of this study is to estimate the seroprevalence of human brucellosis in livestock professionals and analyze the factors associated with brucellosis focusing on sociodemographic variables and the variables of knowledge and practices related to the characteristics of the activities carried out in livestock. | 2017 | 28658364 |
| age and dyssynergia subtypes associated with normal sphincter pressures in women with fecal incontinence. | fecal incontinence (fi) is frequently associated with low sphincter pressures, sensory abnormalities, and advanced age. twenty-three percent of patients with fi and 22% of healthy patients demonstrate dyssynergic defecation (dd) on high-resolution anorectal manometry. overflow incontinence occurs in some dd patients with normal resting and squeeze anal sphincter pressures. our aim was to identify factors associated with normal sphincter pressures in women with fi. | 2017 | 28657991 |
| vaginal uterosacral ligament suspension: a retrospective cohort of absorbable and permanent suture groups. | the aim of this study was to compare anatomic results after vaginal uterosacral ligament suspension with absorbable versus permanent suture. | 2017 | 28657988 |
| incidence of inadvertent dural puncture during ct fluoroscopy-guided interlaminar epidural corticosteroid injections in the cervical spine: an analysis of 974 cases. | the objective of this study is to determine the rate of inadvertent dural puncture during ct fluoroscopy-guided cervical interlaminar epidural corticosteroid injection. in addition, in a subanalysis, we aim to assess the rate of inadvertent dural puncture superior to c5-c6 occurring during interlaminar epidural corticosteroid injection using ct fluoroscopy guidance because such injections are not performed using conventional fluoroscopy. | 2017 | 28657847 |
| identification of an 88-microrna signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases. | hepatocellular carcinoma (hcc) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. in this study, we investigated microrna (mirna) profile of whole blood with a custom microarray containing probes for 1849 mirna species in a total 213 successive subjects who were divided into a discovery set and a validation set. an 88-mirna signature was established to diagnose health controls (hc), chronic hepatitis b (chb), liver cirrhosis (lc) and hcc with 100% a ... | 2017 | 28657540 |
| knowledge, attitudes, and values among physicians working with clinical genomics: a survey of medical oncologists. | it has been over a decade since the completion of the human genome project (hgp), genomic sequencing technologies have yet to become parts of standard of care in canada. this study investigates medical oncologists' (mos) genomic literacy and their experiences based on their participation in a cancer genomics trial in british columbia, canada. | 2017 | 28655303 |
| development and initial implementation of the dynamic assessment treatment algorithm (data). | given the recent increase in transdiagnostic research, it is important to discern how dimensional models of psychopathology could be used to guide personalized, dynamic assessment and treatment of symptoms. using the person-specific approach described by fisher (2015), we devised an initial 4-step algorithm for devising a treatment plan based on modular cognitive behavioral therapy using results obtained from within-person factor analyses and dynamic factor models. then, we describe the improvem ... | 2017 | 28654667 |
| choosing an optimal input for an intravenous glucose tolerance test to aid parameter identification. | the minimal model is used to estimate insulin sensitivity in patients with diabetes, following an intravenous glucose tolerance test (ivgtt). issues have been reported regarding parameter estimation, including correlation between insulin sensitivity and action parameters. the objective was to reduce these issues, by modifying the input of glucose in the test. | 2017 | 28653461 |
| multiple phenotype association tests using summary statistics in genome-wide association studies. | we study in this article jointly testing the associations of a genetic variant with correlated multiple phenotypes using the summary statistics of individual phenotype analysis from genome-wide association studies (gwass). we estimated the between-phenotype correlation matrix using the summary statistics of individual phenotype gwas analyses, and developed genetic association tests for multiple phenotypes by accounting for between-phenotype correlation without the need to access individual-level ... | 2017 | 28653391 |
| predictors of shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage? a systematic review and meta-analysis. | hydrocephalus is a well-recognized complication after aneurysmal subarachnoid hemorrhage (asah). this study aimed to identify predictors for shunt-dependent hydrocephalus (sdhc) after asah via a systematic review and meta-analysis. | 2017 | 28652120 |
| longer-duration antimicrobial therapy does not prevent treatment failure in high-risk patients with complicated intra-abdominal infections. | recent studies have suggested the length of treatment of intra-abdominal infections (iais) can be shortened without detrimental effects on patient outcomes. however, data from high-risk patient populations are lacking. we hypothesized that patients at high risk for treatment failure will benefit from a longer course of antimicrobial therapy. | 2017 | 28650745 |
| trending fibrinolytic dysregulation: fibrinolysis shutdown in the days after injury is associated with poor outcome in severely injured children. | to trend fibrinolysis after injury and determine the influence of traumatic brain injury (tbi) and massive transfusion on fibrinolysis status. | 2017 | 28650356 |
| sonographic comparison of morphologic characteristics between pilonidal cysts and hidradenitis suppurativa. | to compare the sonographic characteristics of pilonidal cysts and hidradenitis suppurativa. | 2017 | 28649748 |
| decreasing prevalence of transmitted drug resistance among art-naive hiv-1-infected patients in iceland, 1996-2012. | introduction: resistance to antiretroviral drugs can complicate the management of hiv-1 infection and impair control of its spread. the aim of the current study was to investigate the prevalence and transmission of hiv-1 drug resistance among 106 antiretroviral therapy (art)-naïve patients diagnosed in iceland (1996-2012). methods: hiv-1 polymerase sequences were analysed using the calibrated population resistance tool. domestic spread of transmitted drug resistance (tdr) was investigated throug ... | 2017 | 28649306 |
| high compliance with scheduled nimodipine is associated with better outcome in aneurysmal subarachnoid hemorrhage patients cotreated with heparin infusion. | we sought to determine whether compliance with scheduled nimodipine in subarachnoid hemorrhage patients impacted patient outcomes, with the intent of guiding future nimodipine management in patients who experience nimodipine-induced hypotension. | 2017 | 28649230 |
| exact results for the probability and stochastic dynamics of fixation in the wright-fisher model. | in this work we consider fixation of an allele in a population. fixation is key to understanding the way long-term evolutionary change occurs at the gene and molecular levels. two basic aspects of fixation are: (i) the chance it occurs and (ii) the way the gene frequency progresses to fixation. we present exact results for both aspects of fixation for the wright-fisher model. we give the exact fixation probability for some different schemes of frequency-dependent selection. we also give the corr ... | 2017 | 28648561 |
| experience with patient referrals for upper extremity transplantation at a u.s. academic medical center. | to date, there have been over 100 upper extremity transplantations (uet) performed worldwide. however, little data are available regarding institutional screening practices or description of the population of patients that seek transplantation as a treatment modality for their upper extremity disabilities. we performed a review of our institutional experience in an attempt to better understand our referral patterns and identify factors that may be associated with successful screening. | 2017 | 28648330 |
| incidence of acute complications following surgery for syndactyly and polydactyly: an analysis of the national surgical quality improvement program database from 2012 to 2014. | congenital hand differences are infrequent phenomena, and their treatment represents a relatively small fraction of cases performed by hand surgeons. little is known about the incidence of wound complications and acute postoperative problems given the relative rarity of these procedures. this study sought to characterize the incidence of complications within 30 days of surgery for congenital hand differences. | 2017 | 28648327 |
| the value of anti-müllerian hormone in predicting clinical pregnancy after intrauterine insemination. | to evaluate the utility of anti-müllerian hormone (amh) in predicting clinical pregnancy with intrauterine insemination (iui) and compare it to other markers of quantitative ovarian reserve. | 2017 | 28647445 |
| [justification of off-label antibiotics uses in hospitalized children]. | unlicensed and off-label (ul/ol) drugs are commonly used in pediatrics wards, especially the antibiotics. it remains unclear if this strategy is justified by randomized controlled trials of good quality? | 2017 | 28647107 |
| a novel habitat-based approach to predict impacts of marine protected areas on fishers. | while marine protected areas (mpas) can simultaneously contribute to biodiversity conservation and fisheries management, the global network is biased towards particular ecosystem types, as it was largely established in an ad hoc fashion. the optimization of trade-offs between biodiversity benefits and socio-economic values increases implementation success and minimizes enforcement costs in the long run, but is often neglected in marine spatial planning (msp). although the acquisition of spatiall ... | 2017 | 28646574 |
| validation of microsatellite instability histology scores with bethesda guidelines in hereditary nonpolyposis colorectal cancer. | hereditary nonpolyposis colorectal cancer (hnpcc) is a subgroup of colorectal cancer (crc) which should be differentiated because of the high risk for additional cancers and risk evaluation for other family members, especially for crc. it is not practical to perform genetic testing for all crc patients; therefore, various prediction modalities, for example, bethesda guideline (bg) were studied in the literature. we aimed to assess the association of microsatellite instability (msi), histology sc ... | 2017 | 28643760 |
| lps alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via tlr4. | this study examined the ability of lipopolysaccharide (lps) to affect glioma and glioma stem-like cells (gscs) in vitro and to induce antitumor immunity in vivo and the role of tlr4 in these processes. | 2017 | 28641579 |
| the importance of data quality for generating reliable distribution models for rare, elusive, and cryptic species. | the availability of spatially referenced environmental data and species occurrence records in online databases enable practitioners to easily generate species distribution models (sdms) for a broad array of taxa. such databases often include occurrence records of unknown reliability, yet little information is available on the influence of data quality on sdms generated for rare, elusive, and cryptic species that are prone to misidentification in the field. we investigated this question for the f ... | 2017 | 28640819 |