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nocardia brasiliensis infection seen on grafted skin of the dorsum of a foot.for the past 4 years a 23 y-old female has noticed erythema on the dorsum of the right foot, where skin was grafted due to a traffic accident 20 years ago. she visited the department of dermatology of gifu prefectural hospital on oct. 19, 1998; her general health was good. physical examination disclosed a swelling with erythema, papules and pustules on the dorsum of the right foot. the results of routine laboratory investigations were within normal limits except for the white blood cell count (1 ...200111479535
nocardiosis in south texas children.primary cutaneous nocardiosis can present as cellulitis or abscess with or without lymphadenitis. in south texas children with suspected staphylococcus aureus or streptococcus pyogenes skin and soft tissue infections who do not improve as expected with appropriate antibiotics, physicians should consider nocardia brasiliensis in the differential diagnosis, especially if there are multiple lesions in a lymphocutaneous distribution.200111465847
sporotrichoid lymphangitis due to group a streptococcus.we describe what is, to our knowledge, the first case of sporotrichoid lymphangitis caused solely by group a streptococcus in an otherwise healthy patient. infection with pyogenic pathogens, such as streptococci and staphylococci, as well as with the most common causes of sporotrichoid lymphangitis (i.e., sporothrix schenkii, nocardia brasiliensis, mycobacterium marinum, and leishmania species) should be considered in differential diagnosis for some patients.200111360227
[anti-nocardia brasiliensis antibodies in patients with actinomycetoma and their clinical usefulness].anti-nocardia brasiliensis antibodies quantification and its clinical utility was confirmed in this study. a protein cellular extract from a n. brasiliensis strain named hujeg-1 and registered at the atcc # 700358 was used in a western blot assay to identify the immunodominant antigens. the protein p24 was selected to set up an elisa test because it exhibit no cross-reaction with sera from tuberculosis and leprosy patients. a purified protease was also used as antigen in the elisa test to compar ...200111244823
lymphocutaneous nocardia brasiliensis infection in children. 200111224857
lymphocutaneous nocardia brasiliensis infection in children. 200111224855
sporotrichoid lymphocutaneous infections: etiology, diagnosis and therapy.sporotrichoid lymphocutaneous infection is an uncommon syndrome that is often misdiagnosed and improperly treated. of the several hundred cases seen each year in the united states, the majority are caused by sporothrix schenckii, nocardia brasiliensis, mycobacterium marinum or leishmania brasiliensis. the "sporotrichoid" disease begins at a site of distal inoculation and leads to the development of nodular lymphangitis. systemic symptoms are characteristically absent. by recognizing the distinct ...200111201697
[nodular lymphangitis caused by nocardia asteroides].nocardia species are typically found in soil and decaying organic matter. the lymphocutaneous type or nodular lymphangitis is unusual. this is acquired in most of cases by a traumatic inoculation through the skin of a person who is immunocompetent, and is generally caused by nocardia brasiliensis.200011153201
lymphocutaneous nocardia brasiliensis infection: a pediatric case cured with amoxicilin/clavulanate. 200011055613
nocardia brasiliensis: from microbe to human and experimental infections.nocardia brasiliensis is a gram-positive bacterium that lives as a saprophyte in soil. in this article the physical properties, chemical composition and taxonomic position of this species is reviewed. human infections and an experimental model of actinomycetoma in balb/c mice as well as the host-immune response is described.200011018454
head actinomycetoma with a double aetiology, caused by nocardia brasiliensis and n. asteroides.we describe a 64-year-old man with an actinomycetoma of the frontal region of the head caused simultaneously by two aetiological agents, nocardia brasiliensis and n. asteroides. this case is presented due to the unusual body site affected and, above all, because two aetiological agents were isolated.200010886160
two cases of mycetoma due to nocardia brasiliensis in central australia.comparatively few cases of mycetoma ("madura foot") have been reported in australia, and only one caused by nocardia brasiliensis. we report two aboriginal women from remote communities in central australia who presented with longstanding mycetomas caused by this organism. difficulties in diagnosis substantially delayed commencement of effective treatment, illustrating the need to consider this condition in chronic suppurative skin infection.200010772588
disseminated nocardia brasiliensis infection in an immunocompromised patient. 199810761018
antitumor activity of brasilicardin a, a novel terpenoid antibiotic from nocardia brasiliensis. 200010724013
a new antifungal macrolide component, brasilinolide b, produced by nocardia brasiliensis. 200010724012
humoral response in a patient with cutaneous nocardiosis.the clinical appearance of infection due to nocardia spp. varies widely. the low sensitivity of direct microscopy and the slow growth of the organism challenge the laboratory diagnosis. we present the case of a skin abscess in an immunocompetent man caused by nocardia brasiliensis. diagnosis was made by cultivation and 16s rrna sequencing. using indirect immunofluorescence and western blot, a strong antibody response to the n. brasiliensis isolate could be demonstrated. serological tests might t ...200010681624
[combined cefotaxime and amikacin for immunomodulation in the treatment of actinomycetoma resistant to conventional treatment].actinomycetoma is a chronic disease that affects subcutaneous tissue. we present a case of a patient with abdominal actinomycetoma caused by nocardia brasiliensis resistant to different treatments over several years, who also presented phagocyte immunodeficiency. he received two cycles (23 day cycles) of cefotaxime, 1 g every 8-h, and amikacin, 500 mg every 12 hours. immunomodulation was carried out with levamisole 300 mg per week, during 4 weeks and bacterial antigen (at a concentration of 600, ...199910596493
production of erythromycin e by pathogenic nocardia brasiliensis. 199910344579
cutaneous nocardiosis caused by nocardia brasiliensis after an insect bite.we report the case of a primary lymphocutaneous nocardiosis occurring on the right calf of a healthy 56-year-old man after an insect bite. analysis of the purulent exudate obtained from the nodule revealed nocardia brasiliensis. the initial therapy with trimethoprim-sulfamethoxazole had to be stopped due to a drug eruption. however, with minocycline treatment the patient recovered within 5 weeks. superficial (sporotrichoid) infections and a history of outdoor injury should be considered suspicio ...199910325464
distribution of a nocardia brasiliensis catalase gene fragment in members of the genera nocardia, gordona, and rhodococcus.an immunodominant protein from nocardia brasiliensis, p61, was subjected to amino-terminal and internal sequence analysis. three sequences of 22, 17, and 38 residues, respectively, were obtained and compared with the protein database from genbank by using the blast system. the sequences showed homology to some eukaryotic catalases and to a bromoperoxidase-catalase from streptomyces violaceus. its identity as a catalase was confirmed by analysis of its enzymatic activity on h2o2 and by a double-s ...199910325357
immune response to nocardia brasiliensis antigens in an experimental model of actinomycetoma in balb/c mice.nine- to twelve-week-old balb/c mice were injected in footpads with 10(7) cfu of a nocardia brasiliensis cell suspension. typical actinomycetoma lesions, characterized by severe local inflammation with abscess and fistula formation, were fully established by day 28 after infection. these changes presented for 90 days, and then tissue repair with scar formation slowly appeared, with complete healing after 150 days of infection. some animals developed bone destruction in the affected area. histopa ...199910225905
brasilicardin a, a new terpenoid antibiotic from pathogenic nocardia brasiliensis: fermentation, isolation and biological activity.a novel tricyclic diterpenoid antibiotic, brasilicardin a, was isolated from the culture broth of nocardia brasiliensis ifm 0406. the antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (mlr) assay system and its ic50 value was 0.057 microg/ml. although the inhibitory activity of cyclosporin a (cya) against il-2 production was confirmed in the mlr assay system, brasilicardin a did not have the activity. the results of in vitro toxicity testing of brasilicardin a ...199910092191
rhodococcus equi and nocardia brasiliensis infection of the brain and liver in a patient with acute nonlymphoblastic leukemia.resolution of neutropenia is usually followed by resolution of fever in patients with febrile neutropenia. however, in some cases fever continues even when the patient is no longer neutropenic. described here is a case of acute myeloblastic leukemia complicated by brain abscess, pulmonary nodules, and hepatic lesions. the patient's fever had continued after the neutropenia resolved; brain and hepatic cultures grew rhodococcus equi and nocardia brasiliensis. although rhodococcus infections occur ...19989865991
antimicrobial susceptibilities of strains of nocardia brasiliensis isolated from soil of tucumán.the activity of antimicrobial agents against soil isolates of n. brasiliensis was studied by determination of the minimum inhibitory concentrations (mics) and disk diffusion technique, according to the national committee for clinical laboratory standards (nccls). the objectives were: (a) to study the patterns of sensitivity among regional strains of n. brasiliensis isolated from natural sources (soil) of different zones of tucumán province; (b) to correlate these results with those previously ob ...19989755502
nothramicin, a new anthracycline antibiotic from nocardia sp. mj896-43f17.a new antibiotic designated nothramicin was isolated from the culture broth of nocardia sp. mj896-43f17 which was closely related to nocardia brasiliensis. it was isolated by the diaion hp-20 column chromatography, butyl acetate extraction and purified by hplc. it inhibited the growth of mycobacteria at the concentration of 1.56 approximately 25 microg/ml. nothramicin was revealed to be a new member of anthracycline antibiotics by the various spectroscopies.19989544933
localized cutaneous nocardia brasiliensis mimicking foreign body granuloma.nocardia brasiliensis is recognized in the united states as an infectious agent of the skin that may present as an abscess, ulcer, or granuloma with or without "sporotrichoid" spread, and rarely causes systemic disease. treatment with trimethoprim/sulfamethoxazole is usually curative. we present a patient with multiple erythematous, painful, draining nodules that developed thirty-six months after trauma and subsequent contamination with soil in bermuda. a foreign body granuloma was suspected cli ...19989538960
brasilinolide a, a new macrolide antibiotic produced by nocardia brasiliensis: producing strain, isolation and biological activity.a new 32-membered macrolide antibiotic, brasilinolide a was isolated from the fermentation broth of nocardia sp. ifm 0406. the producer was identified as nocardia brasiliensis. the antibiotic was only active against aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. brasilinolide a exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (mlr).19979510911
[mastitis caused by nocardia brasiliensis in an immunocompetent patient]. 19979376413
brasilidine a, a new cytotoxic isonitrile-containing indole alkaloid from the actinomycete nocardia brasiliensis. 19979249977
a case of disseminated infection with nocardia brasiliensis in a lung transplant recipient.infection with nocardia species is an increasingly recognized complication of solid organ transplantation. nocardia asteroides accounts for most transplant-related nocardiosis, while nocardia brasiliensis rarely causes infection in organ transplant recipients.19979133485
monoclonal antibodies to p24 and p61 immunodominant antigens from nocardia brasiliensis.we prepared a nocardia brasiliensis cell extract and purified two immunodominant antigens with molecular weights of 61,000 and 24,000. the isolated proteins were shown to be reasonably pure when analyzed with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (8 to 18% polyacrylamide gradient) and stained with coomassie blue and silver nitrate. by using an immunoelectrotransfer blot method (western blotting), we demonstrated that these two purified proteins reacted strongly with serum fro ...19979067645
brasiliquinones a, b and c, new benz[alpha]anthraquinone antibiotics from nocardia brasiliensis. i. producing strain, isolation and biological activities of the antibiotics.new benz[alpha]anthraquinone antibiotics (brasiliquinones a, b and c) with an ethyl group at c-3 were isolated. the producer was identified as nocardia brasiliensis. the antibiotics were active against gram-positive bacteria including mycobacterium sp., but not active against gram-negative bacteria or fungi. they were also active against multiple drug-resistant p388/adr tumor cells.19979066761
role of passive humoral immunity in experimental mycetoma by nocardia brasiliensis. 19968993374
nocardia brasiliensis keratitis successfully treated with therapeutic lamellar keratectomy.a 36-year-old man sustained an indolent keratitis following a minor corneal trauma. nocardia brasiliensis was isolated from cultures of the corneal scrapings. fortified topical antibiotics, based on in vitro drug sensitivity testing, were intensively applied for weeks without clinical improvement. the patient underwent therapeutic lamellar keratectomy, which led to a rapid and complete resolution. the site of the keratectomy reepithelialized within 2 days and became a faint subepithelial haze th ...19968925664
[mycetoma: report of 3 cases in falcón state, venezuela].this is a report of three cases of mycetome studied in our laboratory during the last four years. we also informed about the evolution of the first case produced by pyrenochaeta romeroi nova species reported by borelli in 1959. all the patients were farmer men, 18, 42 and 54 years old, from the semiarid and subhumid zones of falcon state, located on the northwest region of venezuela. clinically, all patients presented the mycetome syndrome (subcutaneous edema, sinus tract and "granules"), with a ...19968920032
a rapid and gentle method for isolation of genomic dna from pathogenic nocardia spp.the lack of simple and efficient methods for extraction of dna from nocardia spp. has hampered molecular manipulation of the dna for diagnostic purposes. in the present study, a method for the rapid extraction of undegraded genomic nocardial dna was established. briefly, 14 pathogenic nocardia strains were grown at 37 degrees c for 3 to 5 days in sauton broth containing 0.05% tween 80. subsequently, the cultures were treated for 48 h with 1.2 mg of cycloserine per ml (final concentration). cells ...19968877144
activities of the glycylcyclines n,n-dimethylglycylamido-minocycline and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline against nocardia spp. and tetracycline-resistant isolates of rapidly growing mycobacteria.susceptibilities to the new semisynthetic tetracycline (tet) compounds n,n-dimethylglycylamido-minocycline (dmg-mino) and n,n-dimethylglycylamido-6-demethyl-6-deoxytetracycline (dmg-dmdot) were compared with those to doxycycline, minocycline, and tet for 198 tet-resistant (tetr) and 33 tet-susceptible (tets) clinical isolates of rapidly growing mycobacteria (rgm) including the mycobacterium fortuitum group, mycobacterium abscessus, mycobacterium chelonae, and mycobacterium mucogenicum and 68 iso ...19968849243
a case of lymphocutaneous nocardiosis with a review of lymphocutaneous nocardiosis reported in japan.an 82-year-old japanese male developed nodules and ulcers along the lymphatics after a fall in the garden of his house resulting in injuries to the dorsum of his left hand which lasted for 3 months. nocardia brasiliensis was isolated from a nodule, supporting a diagnosis of the lymphocutaneous type of nocardiosis. he had previously developed generalized bone metastasis from prostatic cancer, and his resulting depressed immunity might have played a part in the nocardiosis genesis. sixteen cases o ...19968839240
nocardia brasiliensis: in vitro and in vivo growth response to steroid sex hormones.as actinomycetoma is more frequent in males than in females, the possibility that hormones might modify the nocardia brasiliensis growth and the course of experimental actinomycetoma was explored. five n. brasiliensis strains were grown on sabouraud agar containing estradiol, progesterone or testosterone, in 3 different concentrations. colony diameters were measured weekly for 7 weeks. n. brasiliensis strains were also grown in sabouraud broth containing hormones. glucose concentration was measu ...19958819830
isolation and characterisation of nocardia from clinical specimens.sixteen isolations of nocardia of which 12 were from pulmonary infections, one from wound infection, one from mycetoma and 2 from eye infections were studied from june, 1989 to may, 1990. the importance of gram's stain findings of primary smear is being highlighted. the nocardia species were identified utilising the morphological characters including acid fastness and cultural and biochemical characters. notable among the isolates were nocardia brasiliensis, one each from mycetoma and pulmonary ...19968810179
a palmar chancre and multiple proximal erythematous nodules. nodular lymphangitis due to nocardia brasiliensis. 19968712850
an acute nocardia brasiliensis infection of the hand: a case report. 19968683074
nocardia pseudobrasiliensis sp. nov., a new species of nocardia which groups bacterial strains previously identified as nocardia brasiliensis and associated with invasive diseases.we studied five strains of a new nocardia taxon recently identified among nocardia brasiliensis strains associated with invasive diseases (r. j. wallace, jr., b. a. brown, z. blacklock, r. ulrich, k. jost, j. m. brown, m. m. mcneil, g. onyi, v. a. steingrube, and j. gibson, j. clin. microbiol. 33:1528-1533, 1995) to determine their taxonomic status. several characteristics of these organisms, including the presence of chemotype iv cell walls, nocardomycolic acids, a predominant menaquinone simil ...19968573505
brain abscess due to nocardia brasiliensis hematogenously spread from a pulmonary infection. 19958562775
nocardiosis in renal transplant recipients undergoing immunosuppression with cyclosporine.nine cases of nocardiosis were diagnosed among 1,255 renal transplant recipients given cyclosporine (csa)-prednisone for immunosuppression between august 1980 and march 1992 (incidence, 0.7%). of these nine patients presenting with nocardiosis 32-1,806 days after transplantation, eight had pulmonary involvement, two had skin manifestations (one with localized disease), and one had a cerebral abscess and a pleural effusion. all cases required aggressive diagnostic procedures. nocardia asteroides ...19938513056
treatment of a nocardia brasiliensis mycetoma with sulfamethoxazole and trimethoprim, amikacin, and amoxicillin and clavulanate. 19938481016
nodular lymphangitis: a distinctive but often unrecognized syndrome.to describe nodular lymphangitis by reviewing the clinical and epidemiologic features of this disease with an emphasis on distinguishing specific etiologic agents.19938480962
nocardia brasiliensis liver abscesses in an aids patient: imaging findings. 19938456695
amoxicillin and clavulanic acid in the treatment of actinomycetoma.mycetoma is a relatively frequent disease in tropical countries. drugs commonly used need a long period of treatment, and some cases are resistant to these drugs, especially those with bone or visceral involvement. the combination of amoxicillin-clavulanic acid has shown effectiveness against strains of nocardia brasiliensis in vitro.19938444539
pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis. i. taxonomy, fermentation and biological activity.an actinomycete strain sc-4710, a new soil isolate, was found to produce a new macrolide antibiotic, pc-766b. chemotaxonomic analysis of the producing organism revealed that the cells of sc-4710 had type iv cell wall, type a whole cell sugar pattern, type pii phospholipids, menaquinone mk-8(h4), cellular fatty acids comprising straight-chain saturated, unsaturated and tuberculostearic acids, and mycolic acids. the strain was identified as nocardia brasiliensis (lindenberg) pinoy. the antibiotic, ...19938393851
mycetoma: a retrospective study of 41 cases seen in são paulo, brazil, from 1978 to 1989.clinical and epidemiological aspects of 41 cases of mycetoma seen in são paulo city from january 1978 to december 1989 are presented. twenty-eight cases (68%) were caused by actinomycetes, while 13 (32%) were caused by true fungi. in only 22 (78%) actinomycetoma cases was it possible to identify the agent. nocardia brasiliensis, by far the commonest actinomycete isolated, was responsible for 13 cases. among eumycetomata, madurella grisea was isolated from 3 cases, scedosporium apiospermum from 2 ...19938366881
pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis. ii. isolation, physico-chemical properties and structure elucidation.a new macrolide antibiotic, pc-766b, was isolated from the cells of nocardia brasiliensis sc-4710 by acetone extraction, and purified by gel filtration, silica gel chromatography, hplc and tlc. the structure of pc-766b was determined by nmr spectral analysis to be a new class of the hygrolidin family antibiotics. pc-766b had a 16-membered macrocyclic lactone ring, a 6-membered hemiketal ring and a 2-deoxy-d-rhamnose moiety. dl-alpha-tocopherol, known as an antioxidant agent, significantly improv ...19938360110
inactivation of rifampin by nocardia brasiliensis.rifampin was glycosylated by a pathogenic species of nocardia, i.e., nocardia brasiliensis. the structures of two glycosylated compounds (rip-1 and rip-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(o-[beta-d-glucopyranosyl])rifamycin sv and 23-(o-[beta-d-glucopyranosyl])rifampin, respectively. both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the nocardia species.19938328779
cervicofacial nocardiosis caused by nocardia brasiliensis in an adult. 19938286649
enzyme-linked immunosorbent assay for serological diagnosis of nocardia brasiliensis and clinical correlation with mycetoma infections.we previously identified three immunodominant antigens obtained from a nocardia brasiliensis cell extract and recognized by sera from mycetoma patients (m. c. salinas-carmona, l. vera, o. welsh, and m. rodríguez, zentralbl. bakteriol. 276:390-397, 1992). in the present work, we obtained a crude extract from a mass culture of n. brasiliensis hujeg-1 and purified two immunodominant antigens, the 26- and 24-kda proteins, by using simple physiochemical techniques. with these antigens, we developed a ...19938263174
nodular lymphadenitis caused by nocardia brasiliensis. 19948075295
lymphocutaneous nocardia brasiliensis infection transmitted via a cat scratch: a second case. 19948038327
three new reduced anthracycline related compounds from pathogenic nocardia brasiliensis.three new metabolites were isolated from a pathogenic bacterium, nocardia brasiliensis ifm 0075 strain, a producer of a new anthracycline antibiotic (so-075r1) and its mutant strain (ifm 0075-13-1). the structural studies showed that they are reduced anthracyline related compounds. some biosynthetic routes of these metabolites were discussed.19947928699
concurrent chromoblastomycosis caused by fonsecaea pedrosoi and actinomycetoma caused by nocardia brasiliensis.chromoblastomycosis and mycetoma are chronic infections caused by the repeated traumatic inoculation of organisms into the skin and subcutaneous tissue. chromoblastomycosis is caused by several dematiaceous (pigmented) fungi, occurs in tropical regions, and usually affects the lower extremities. the lesions may be nodules, plaques, or tumorous masses. mycetomas are caused by either true fungi (eumycetes) or filamentous bacteria (actinomycetes); they also occur predominantly in tropical areas and ...19957829748
unusually located lymphocutaneous nocardiosis caused by nocardia brasiliensis.we report a patient with primary lymphocutaneous nocardia brasiliensis infection affecting the face and left arm. the mode of infection was via skin abrasions which occurred 2 weeks prior to the development of the skin lesions. treatment with intravenous minocycline for 4 weeks resulted in a cure. we also review 12 previously reported japanese cases of lymphocutaneous nocardiosis.19957748754
lymphocutaneous nocardiosis with multiple subcutaneous nodules distributed over the extensor aspect of the forearm. report of a case.we report a case of lymphocutaneous nocardiosis due to nocardia brasiliensis, marked by multiple subcutaneous nodules and abscesses on the extensor aspect of the left forearm in a 53-year-old woman with systemic lupus erythematosus. nine months before she was first examined, she had fallen on a concrete surface. a nodule had appeared 2 months later at the same site and had expanded and been followed by others, which finally covered most of the extensor aspect of the forearm. we speculated that t ...19947701876
new nocardia taxon among isolates of nocardia brasiliensis associated with invasive disease.nocardia brasiliensis, the second most frequently isolated aerobic actinomycete in the clinical laboratory, is usually associated with localized cutaneous infections. however, 22% of 238 n. brasiliensis isolates from the united states and 12% of 66 isolates from queensland, australia, which had been collected over a 17-year period, were associated with extracutaneous and/or disseminated diseases. of the 62 invasive isolates, 37 (60%) were susceptible to ciprofloxacin and/or were susceptible to c ...19957650180
lymphocutaneous nocardia brasiliensis infection: a case report and review. 19957566789
nocardia brasiliensis in a horse with pneumonia and pleuritis.a 15 month-old quarter horse colt developed severe bacterial pneumonia and effusive pleuritis. a beta-hemolytic streptococcus was isolated from a tracheal wash specimen but the colt died despite conventional therapy. the gross post mortem and histologic lesions were characteristic of pulmonary nocardiosis. nocardia brasiliensis was isolated from the lung and bronchial lymph node.19807460568
experimental production of actinomycetoma in balb/c mice.chronic actinomycetoma associated with grain production was induced in balb/c mice by subcutaneous inoculation of live nocardia brasiliensis in freund incomplete adjuvant into the hind footpads. similar inoculation of n. asteroides and n. caviae resulted in local tumor formation which healed spontaneously after 5 months, the disease disseminating into the peritoneum, where masses or organisms could be detected. grains were recovered from superficial skin lesions of n. caviae, but not from the n. ...19807429630
resistance to nocardia brasiliensis infection in mice immunized with either nocardia or bcg.different vaccination procedures to increase the mechanisms of host resistance to nocardia brasiliensis were studied in mice. when mice were challenged in the footpad, 2 x 10(8) n. brasiliensis 20 days after footpad inoculation with either viable or killed n. brasiliensis, the mice demonstrated significant resistance to infection when compared with noninfected and nonimmunized mice. the degree of resistance seems to be correlated with the delayed-type hypersensitivity response in the vaccinated ...19807393313
nocardia brasiliensis-mycetoma--(a case report). 19827175764
[sporotrichoid infection caused by nocardia brasiliensis].a few days after a spine of one of his indoor cacti had pricked the fourth finger of his left hand, a 56-year-old man developed multiple inflammatory suppurating nodules and infiltrates and a cord-like lymphangitis on the left forearm and upper arm. nocardia brasiliensis was cultivated from aspirated pus. subsequently, both nocardia brasiliensis and nocardia asteroides were isolated from the cactus earth. this is the first report of an infection by nocardia brasiliensis acquired in germany.19827152897
nocardia brasiliensis: mycetoma induction and growth cycle.the capacity of nocardia brasiliensis to induce mycetoma in balb/c mice in the absence of adjuvants was studied. whether the virulence of n. brasiliensis varied in the different phases of its growth cycle was also determined. the results showed that n. brasiliensis suspended in 0.15 m nacl and injected into the footpads of mice were able to induce mycetoma after only 14 days of infection, as evidenced by histological studies. data are also presented indicating that the virulence of n. brasiliens ...19827152671
numerical and chemical classification of nocardia amarae.twenty-one strains of nocardia amarae and marker cultures of mycobacterium, nocardia, rhodococcus and the 'aurantiaca' taxon were subjected to numerical phenetic analyses using 92 unit characters. the data were examined using the simple matching (ssm), jaccard (sj) and pattern (dp) coefficients and clustering was achieved using the unweighted average linkage algorithm. neither cluster nor aggregate cluster composition was markedly affected by the coefficient used or by test error, estimated at 1 ...19827119738
an ultrastructural comparison of the cell envelopes of selected strains of nocardia asteroides and nocardia brasiliensis.growth curves were determined for three strains each of nocardia asteroides and nocardia brasiliensis. two strains of n. brasiliensis and one strain of n. asteroides had longer lag periods of growth than the remaining three strains. all strains had generation times of approximately 5.5 hours. the ultrastructure of the cell envelope of each nocardia strain in early stationary phase growth was also examined. all the strains had typical trilaminar cell walls and cell membranes. the thickness of the ...19806990267
enhanced resistance to nocardia brasiliensis infection in mice depleted of antigen-specific b cells.this study deals with the roles of t and b cells in nocardia brasiliensis infection in mice. nocardia injected into the animals' footpads caused inflammatory responses and mycetomas in situ, resulting in granulomatous lesions of subcutaneous tissues and eventual bone destruction. these clinical features resemble those of humans infected with nocardia. the effect, if any, of antibody was studied by passively transferring anti-nocardia serum into either immunologically normal or t-deficient infect ...19826980947
immunoglobulin and complement in tissues of mice infected with nocardia brasiliensis.two weeks after mice had been infected in the footpad with cells of nocardia brasiliensis, immunoglobulin and c3 deposits were observed in tissue from the inoculation site. both immunoglobulin and c3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in which plasma cells were also present. although anti-n. brasiliensis specificity was evidenced at 14 days postinfection in an eluate of infected tissue by an immunoenzymatic assay, no ...19836852920
[fatty acid composition of the lipids of streptomycetes and their nocardia-like mutants].the models "population--nocardia-like spontaneous mutants" for 14 cultures of streptomycetes and streptoverticillium were used to assess the fatty acid composition of lipids as a criterion for generic differentiation of streptomyces and nocardia cultures. the composition of fatty acids in the nocardia-like mutant str. kanamyceticus ria-771 was found to be identical with that of nocardia asteroides ria-43 and nocardia brasiliensis ria-440, i. e. generic chemotaxonomic traits "overlapped" in the p ...19806777646
[experimental pathogenicity of isolates of nocardia asteroides, nocardia brasiliensis and nocardia caviae from different sources].the experimental pathogenicity of 14 isolates of nocardia brasiliensis, 15 of n. asteroides, and 5 of n. caviae was investigated for the white swiss mice inoculated intraperitoneally and in the foot pad, and for the guinea-pig and the hamster (mesocricetus auratus) both inoculated intratesticularly. the guinea-pig was remarkably sensitive to n. asteroides, with an apparent relationship between pathogenicity and thermotolerance, confirming previous observations. mice were in general less suscepti ...19826760417
nocardia brasiliensis lymphocutaneous syndrome in a patient with lymphosarcoma. 19846548715
disseminated cutaneous nocardia brasiliensis infection.nocardia brasiliensis is an uncommon pathogen in the united states despite its presence in soil samples. it is most frequently seen in patients who are immunosuppressed, but can occur in the immunocompetent host also. usually in a healthy host the infection is localized to one area of the body. disseminated infection was diagnosed in a healthy child who recovered fully after initiation of oral sulfonamide therapy. we suspect that the source was soil to which the patient was exposed during a fami ...19846504778
the clinical spectrum of nocardia brasiliensis infection in the united states.seven cases of infection due to nocardia brasiliensis were identified over a 13-year period at duke university medical center, durham, north carolina. these seven cases and a review of 55 cases in the literature reported from the united states show that n. brasiliensis can cause a wide spectrum of disease. forty-six of the 62 patients had disease of skin and soft tissues. cutaneous manifestations included cellulitis, pustules, ulcerations, pyoderma, subcutaneous abscesses, a lymphocutaneous synd ...19846374833
preliminary evaluation of a passive hemagglutination assay and enzyme-linked immunosorbent assay for actinomycetoma caused by nocardia brasiliensis. 19846368227
[mycetoma in northern argentina].from 1972 to october 1982 we have observed 39 cases of mycetoma in the skin department of the hospital del milagro, salta (argentina). the diagnosis was based on the clinical aspect, mycological studies and in most cases histopathology was done as well. the mayoritary of the patients were farmers. from the clinical point of view there si a true prevalence of nocardia brasiliensis. most of the mycetomas can be found in the lower limbs. some of the patients presented quite severe lesions and eight ...19836366400
purification and partial characterization of a nocardia brasiliensis extracellular protease.nocardia brasiliensis possess proteolytic activities that can be readily detected in a variety of media. in a modified formulation of a growth medium originally used for streptomyces aureofaciens, n. brasiliensis was found to secrete proteolytic enzymes, one of which was capable of hydrolyzing casein. this enzyme was purified to homogeneity from cell-free culture filtrates of n. brasiliensis. the purification procedure included ion-exchange chromatography on carboxymethyl-sepharose, gel filtrati ...19846363390
failure of sulfonamides and trimethoprim in the treatment of nocardiosis.an immunocompromised patient with nocardia brasiliensis pneumonia and empyema acquired disseminated disease due to nocardia asteroides and died. the treatment of choice for pulmonary or disseminated nocardiosis is 6 to 12 g/day of sulfisoxazole (or adjusted dosage to achieve a serum level of 100 to 150 mg/l) continued for six to 18 months. combination therapy may be beneficial in selected patients; if trimethoprim therapy is used with sulfonamides, higher than usual doses of trimethoprim may be ...19836337576
sensitivity to capreomycin and prothionamide in strains of mycobacterium, nocardia, rhodococcus, and related taxa for taxonomical purposes.sensitivity to capreomycin and to prothionamide was analysed for 150 strains belonging to the genera mycobacterium, nocardia, rhodococcus, and related taxa. the analyses showed, e.g., that strains of mycobacterium chelonei and nocardia brasiliensis were more resistant to capreomycin than the other strains tested and that m. farcinogenes differed from m. senegalense concerning sensitivity to this drug. the analysis showed, furthermore, that strains of mycobacterium differ from those of nocardia, ...19836196927
sporotrichoid nocardiosis caused by nocardia brasiliensis. 19676023043
[action "in vitro" of a sulfonamide, ro-44393, on actinomyces brasiliensis (nocardia brasiliensis)]. 19665997146
electron microscopic studies on granules of nocardia brasiliensis in man. 19665977763
mycetoma caused by nocardia brasiliensis in missouri. case report. 19665946294
primary chancriform syndrome caused by nocardia brasiliensis. 19665900706
mycetoma by nocardia brasiliensis successfully treated with ethambutol. 19695368017
[treatment of mycetoma caused by nocardia brasiliensis using a new sulfamide administered once a week]. 19655263083
rifkind d: nocardia brasiliensis lymphocutaneous syndrome. 19715102581
mycetoma due to nocardia brasiliensis. 19704989461
[presence of an antigen in mycobacterium lepraemurium which is also common in mycobacterium leprae and nocardia brasilensis]. 19674971556
systemic nocardiosis caused by nocardia brasiliensis. 19744809153
nocardia brasiliensis infection in the united states: a report of nine cases and a review of the literature. 19734720402
disseminated nocardia brasiliensis infection. 19734701385
lymphocutaneous nocardia brasiliensis infection mimicking sporotrichosis. 19734698772
mycetoma of the foot caused by nocardia brasiliensis. 19724624524
mycetomas caused by curvularia lunata, madurella grisea, aspergillus nidulans, and nocardia brasiliensis in sudan. 19734584205
chemotherapeutic sensitivity and viability of nocardia asteroides and nocardia brasiliensis in drugs. 19734584078
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