Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| cutaneous plasmacytosis resembling pityriasis rosea in a 66-year-old white woman: a rare disease presenting in an unusual patient demographic. | 2017 | 28203625 | |
| simultaneous detection of dual nucleic acids using a sers-based lateral flow assay biosensor. | a new class of surface-enhanced raman scattering (sers)-based lateral flow assay (lfa) biosensor has been developed for the simultaneous detection of dual dna markers. the lfa strip in this sensor was composed of two test lines and one control line. sers nano tags labeled with detection dna probes were used for quantitative evaluation of dual dna markers with high sensitivity. target dna, associated with kaposi's sarcoma-associated herpesvirus (kshv) and bacillary angiomatosis (ba), were tested ... | 2017 | 28194991 |
| molecular epidemiology of kaposi's sarcoma-associated herpes virus, and risk factors in hiv-infected patients in tehran, 2014. | kaposi's sarcoma (ks) remains the most common malignancy among hiv-infected patients. human herpesvirus type-8 (hhv-8) is regarded as the infectious etiological agent of kaposi's sarcoma (kshv). diagnostic procedures associated with kshv are not routinely performed in hiv-infected subjects. | 2016 | 28191343 |
| castlemans disease - surgical treatment, case reports. | the authors describe their experience with surgical treatment of benign rare lymph proliferation - castlemans disease (cd). it occurs in unicentric and multicentric forms. the very low incidence of the disease makes it very difficult to design larger prospective studies. cases of two leading localizations of the unicentric form of cd - intrathoracic and retroperitoneal with special emphasis on the preoperative diagnosis and imaging options are described. this article underlines the curative pote ... | 2016 | 28182443 |
| kaposi's sarcoma-associated herpesvirus (kshv)-encoded micrornas promote matrix metalloproteinases (mmps) expression and pro-angiogenic cytokine secretion in endothelial cells. | the human oncogenic virus kaposi's sarcoma-associated herpesvirus (kshv) is linked to kaposi's sarcoma (ks), a tumor of endothelial cells characterized by angiogenesis and invasiveness. kshv genome encodes 25 mature micrornas (mirnas), but their roles in kshv-induced tumor dissemination and angiogenesis are not fully understood. in this study, we constructed the sensor reporters of kshv mirnas and used a luciferase reporter assay to demonstrate the function of the mimics of kshv mirnas. then, we ... | 2017 | 28165144 |
| methylseleninic acid and sodium selenite induce severe er stress and subsequent apoptosis through upr activation in pel cells. | selenium compounds such as methylseleninic acid (msa) and sodium selenite (ss) have been widely evaluated as potential anti-cancer agents in the clinical setting. primary effusion lymphoma (pel) is a non-hodgkin's b-cell lymphoma, associated with immunosuppressed individuals, such as post-transplant or aids patients. kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of pel and kaposi's sarcoma. here, we found that msa and ss markedly inhibited the growth of pel cells compared ... | 2017 | 28161410 |
| successful treatment of classic kaposi sarcoma with long-pulse neodymium-doped yttrium aluminum garnet laser: a preliminary study. | kaposi sarcoma (ks) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. the treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema. | 2017 | 28157730 |
| up-regulation of tumor suppressor genes by exogenous dhc16-cer contributes to its anti-cancer activity in primary effusion lymphoma. | primary effusion lymphoma (pel) is a rare and highly aggressive b-cell malignancy with kaposi's sarcoma-associated herpesvirus (kshv) infection, while lack of effective therapies. our recent data indicated that targeting the sphingolipid metabolism by either sphingosine kinase inhibitor or exogenous ceramide species induces pel cell apoptosis and suppresses tumor progression in vivo. however, the underlying mechanisms for these exogenous ceramides "killing" pel cells remain largely unknown. base ... | 2017 | 28146424 |
| relapse of hhv8-positive multicentric castleman disease following rituximab-based therapy in hiv-positive patients. | successful treatment of hiv-associated multicentric castleman disease (hiv+mcd) with rituximab-based approaches has dramatically improved survival and reduced the risk of human herpesvirus 8 (hhv8)-associated lymphoma. longer term outcomes including relapse rates have not been described and are important to establish the potential role of maintenance therapy. a prospective cohort of 84 patients with biopsy-proven hiv+mcd were treated with risk-stratified rituximab-based therapy. four patients (5 ... | 2017 | 28143881 |
| tafro syndrome: new subtype of idiopathic multicentric castleman disease. | castleman disease (cd) describes a group of three rare and poorly understood lymphoproliferative disorders that have heterogeneous clinical symptoms and common lymph node histopathological features. unicentric cd (ucd) involves a single region of enlarged nodes. multicentric cd (mcd) involves multiple regions of enlarged lymph nodes, constitutional symptoms, and organ dysfunction due to a cytokine storm often including interleukin 6. mcd is further divided into human herpes virus-8 (hhv-8)-assoc ... | 2017 | 28135567 |
| cross-sectional and longitudinal investigation of human herpesvirus 8 seroprevalence in hiv-1-infected individuals in osaka, japan. | high human herpesvirus 8 (hhv-8) seroprevalence has been reported in men who have sex with men (msm) and are infected with hiv-1. however, it is unclear when they become infected with hhv-8. thus, we conducted cross-sectional and longitudinal investigations of hhv-8 seroprevalence in hiv-1-infected individuals in osaka, japan. | 2017 | 28131739 |
| sero-prevalence of bloodborne tumor viruses (hcv, hbv, htlv-i and kshv infections) and related risk factors among prisoners in razavi khorasan province, iran, in 2008. | prisoners are at high risk of blood borne and sexually transmitted infections due to their high involvement in risky behaviors. in this descriptive/cross-sectional study, the prevalence, sero-prevalence, and risk factors for bloodborne tumor viruses including htlv-i, hbv, hcv, and kshv were evaluated among inmates of two central prisons in the northeast of iran. | 2016 | 28123439 |
| regulatory t cell effect on cd8(+) t cell responses to human herpesvirus 8 infection and development of kaposi's sarcoma. | we assessed cd8(+) t cell reactivity to human herpesvirus 8 (hhv-8; kaposi's sarcoma [ks]-associated herpesvirus) and the role of cd4(+)cd25(hi)foxp3(+) regulatory t cells (treg) in hhv-8- and hiv-coinfected participants of the multicenter aids cohort study who did or did not develop ks. there were similarly low cd8(+) t cell interferon-γ responses to mhc class i-restricted epitopes of hhv-8 lytic and latent proteins over 5.7 years before ks in participants who developed ks compared to those who ... | 2017 | 28121161 |
| use of plasma human herpesvirus-8 viral load measurement: evaluation of practice in three uk hiv treatment centres. | a retrospective audit of plasma human herpesvirus-8 (hhv-8) viral load testing was performed in three hiv treatment centres over 24 months. reasons for testing (360 tests) were: symptoms of systemic inflammatory response syndrome (sirs) (fever, lymphadenopathy and raised inflammatory markers); monitoring in known hhv-8 pathology other than kaposi sarcoma (ks); investigation of known/suspected ks, and other/no reason. of patients with multicentric castleman disease (mcd), 14/16 (88%) had detectab ... | 2017 | 28120699 |
| epigenetic landscape of kaposi's sarcoma-associated herpesvirus genome in classic kaposi's sarcoma tissues. | kaposi's sarcoma-associated herpesvirus (kshv) is etiologically related to kaposi's sarcoma (ks), primary effusion lymphoma (pel) and multicentric castleman's disease (mcd). it typically displays two different phases in its life cycle, the default latency and occasional lytic replication. the epigenetic modifications are thought to determine the fate of kshv infection. previous studies elegantly depicted epigenetic landscape of latent viral genome in in vitro cell culture systems. however, the p ... | 2017 | 28118409 |
| elevated serum psa is associated with human herpesvirus 8 infection and increased circulating cytokine levels in men from tobago. | serum-prostate specific antigen (psa) levels have been used for many years as a biomarker for prostate cancer. this usage is under scrutiny due to the fact that elevated psa levels can be caused by other conditions such as benign prostatic hyperplasia and infections of or injury to the prostate. as a result, the identification of specific pathogens capable of increasing serum levels of psa is important. a potential candidate responsible for elevated psa is human herpesvirus 8 (hhv-8). we have re ... | 2017 | 28117495 |
| bet-inhibitors disrupt rad21-dependent conformational control of kshv latency. | kaposi's sarcoma-associated herpesvirus (kshv) establishes stable latent infection in b-lymphocytes and pleural effusion lymphomas (pels). during latency, the viral genome persists as an epigenetically constrained episome with restricted gene expression programs. to identify epigenetic regulators of kshv latency, we screened a focused small molecule library containing known inhibitors of epigenetic factors. we identified jq1, a bromodomain and extended terminal (bet) protein inhibitor, as a pote ... | 2017 | 28107481 |
| the promise of proteomics in the study of oncogenic viruses. | oncogenic viruses are responsible for about 15% human cancers. this article explores the promise and challenges of viral proteomics in the study of the oncogenic human dna viruses, hpv, mcpyv, ebv and kshv. these viruses have coevolved with their hosts and cause persistent infections. each virus encodes oncoproteins that manipulate key cellular pathways to promote viral replication and evade the host immune response. viral proteomics can identify cellular pathways perturbed by viral infection, i ... | 2017 | 28104704 |
| viral micrornas target a gene network, inhibit stat activation, and suppress interferon responses. | kaposi's sarcoma-associated herpesvirus (kshv) encodes 12 pre-micrornas during latency that are processed to yield ~25 mature micrornas (mirnas). we were interested in identifying cellular networks that were targeted by kshv-mirnas and employed network building strategies using validated kshv mirna targets. here, we report the identification of a gene network centering on the transcription factor- signal transducer and activator of transcription 3 (stat3) that is targeted by kshv mirnas. kshv mi ... | 2017 | 28102325 |
| efficacy of a film-forming medical device containing piroxicam and sun filters in the treatment of multiple actinic keratosis lesions in a subject with a history of kaposi sarcoma. | actinic keratosis (ak) is considered a premalignant form of skin cancer due to chronic sun exposure. in addition, human papilloma virus (hpv) has been advocated a role in the pathogenesis of this clinical condition. hpv proteins (mainly e6 and e7) seem to act synergistically with ultraviolet (uv) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after uv damage. data regarding the involvement of other viruses, i.e. human herpes viruses (hhv), in the pathogenesis of ak are ... | 2017 | 28101017 |
| clinical and pathological characteristics of hiv- and hhv-8-negative castleman disease. | castleman disease (cd) comprises 3 poorly understood lymphoproliferative variants sharing several common histopathological features. unicentric cd (ucd) is localized to a single region of lymph nodes. multicentric cd (mcd) manifests with systemic inflammatory symptoms and organ dysfunction due to cytokine dysregulation and involves multiple lymph node regions. human herpesvirus 8 (hhv-8) causes mcd (hhv-8-associated mcd) in immunocompromised individuals, such as hiv-infected patients. however, > ... | 2017 | 28100459 |
| angiosarcoma in hiv-negative patients is not associated with hhv-8. | angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. herpes virus 8 (hhv-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as kaposi's sarcoma. the role of hhv-8 in the pathogenesis of angiosarcoma has not been well defined. | 2017 | 28099593 |
| nuclear localization and cleavage of stat6 is induced by kaposi's sarcoma-associated herpesvirus for viral latency. | emerging evidence implies that stat6 plays an important role in both the adaptive and innate immune responses to virus infection. kaposi's sarcoma-associated herpesvirus (kshv) is an oncogenic γ-herpesvirus agent associated with several human malignancies, including kaposi's sarcoma (ks) and primary effusion lymphomas (pels). previously, we demonstrated that kshv blocks il-4-induced stat6 phosphorylation and retains a basal il-13/stat6 constitutive activation for cell survival and proliferation. ... | 2017 | 28099521 |
| quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting pi3k/akt/mtor and stat3 signaling pathways. | quercetin, a bioflavonoid contained in several vegetables daily consumed, has been studied for long time for its antiinflammatory and anticancer properties. quercetin interacts with multiple cancer-related pathways such as pi3k/akt, wnt/β-catenin and stat3. these pathways are hyperactivated in primary effusion lymphoma (pel), an aggressive b cell lymphoma whose pathogenesis is strictly linked to the oncogenic virus kaposis' sarcoma-associated herpesvirus (kshv). in this study, we found that quer ... | 2017 | 28092744 |
| international, evidence-based consensus diagnostic criteria for hhv-8-negative/idiopathic multicentric castleman disease. | human herpesvirus-8 (hhv-8)-negative, idiopathic multicentric castleman disease (imcd) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction caused by a cytokine storm often including interleukin-6. imcd accounts for one third to one half of all cases of mcd and can occur in individuals of any age. accurate diagnosis is challenging, because no standard diagnostic criteria or diagnostic b ... | 2017 | 28087540 |
| talc pleurodesis allows long-term remission in hiv-unrelated human herpesvirus 8-associated primary effusion lymphoma. | 2017 | 28084853 | |
| hhv8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma. | human herpesvirus 8 (hhv8)-associated lymphoid proliferations are uncommon and poorly characterized disorders mainly affecting immunosuppressed patients, especially with hiv infection. they encompass different diseases with overlapping features that complicate their classification. in addition, the role of hhv8 in reactive lymphoid hyperplasia is not well known. to analyze the clinicopathological spectrum of these lesions, we have reviewed 66 biopsies of 61 patients with hhv8 infection. all case ... | 2017 | 28084335 |
| inkt and memory b-cell alterations in hhv-8 multicentric castleman disease. | human herpesvirus 8 (hhv-8) is the causative agent of kaposi sarcoma (ks) and multicentric castleman disease (mcd), a life-threatening, virally induced b-cell lymphoproliferative disorder. hhv-8 is a b-lymphotropic γ-herpesvirus closely related to the epstein-barr virus (ebv). invariant natural killer t (inkt) cells are innate-like t cells that play a role in antiviral immunity, specifically in controlling viral replication in ebv-infected b cells. decline of inkt cells is associated with age or ... | 2017 | 28060720 |
| the viral bcl-2 homologs of kaposi's sarcoma-associated herpesvirus and rhesus rhadinovirus share an essential role for viral replication. | ks-bcl-2 is a kaposi's sarcoma-associated herpesvirus (kshv)-encoded viral bcl-2 (vbcl-2) homolog which has apoptosis- and autophagy-inhibiting activity when expressed in transfected cells. however, little is known about its function during viral infection. as ks-bcl-2 is expressed during the lytic replication cycle, we used constitutively lytic and inducibly lytic kshv mutants to investigate the role of ks-bcl-2 during the lytic cycle. we show that kshv cannot complete the lytic replication cyc ... | 2017 | 28053098 |
| ultraviolet radiation and kaposi sarcoma incidence in a nationwide us cohort of hiv-infected men. | although ultraviolet radiation (uvr) is established as both an inducer of herpes simplex virus reactivation and as the primary risk factor for many common skin cancers, its relationship with human herpes virus 8 (hhv8) infection or risk of kaposi sarcoma (ks) is unknown. | 2017 | 28040691 |
| 3-d microwell array system for culturing virus infected tumor cells. | cancer cells have been increasingly grown in pharmaceutical research to understand tumorigenesis and develop new therapeutic drugs. currently, cells are typically grown using two-dimensional (2-d) cell culture approaches, where the native tumor microenvironment is difficult to recapitulate. thus, one of the main obstacles in oncology is the lack of proper infection models that recount main features present in tumors. in recent years, microtechnology-based platforms have been employed to generate ... | 2016 | 28004818 |
| oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy treatment for head and neck squamous cell carcinoma. | opportunistic infections may affect the oral mucosa of patients undergoing radio/chemotherapy through exacerbation of oral mucositis. the aim of this study is to evaluate the oral shedding of all eight human herpesviruses and its possible association with oral mucositis. | 2016 | 27966015 |
| niclosamide inhibits lytic replication of epstein-barr virus by disrupting mtor activation. | infection with the oncogenic γ-herpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) cause several severe malignancies in humans. inhibition of the lytic replication of ebv and kshv eliminates the reservoir of persistent infection and transmission, consequently preventing the occurrence of diseases from the sources of infection. antiviral drugs are limited in controlling these viral infectious diseases. here, we demonstrate that niclosamide, an old anthelminti ... | 2017 | 27939840 |
| structural analysis of thymidylate synthase from kaposi's sarcoma-associated herpesvirus with the anticancer drug raltitrexed. | kaposi's sarcoma-associated herpesvirus (kshv) is a highly infectious human herpesvirus that causes kaposi's sarcoma. kshv encodes functional thymidylate synthase, which is a target for anticancer drugs such as raltitrexed or 5-fluorouracil. thymidylate synthase catalyzes the conversion of 2'-deoxyuridine-5'-monophosphate (dump) to thymidine-5'-monophosphate (dtmp) using 5,10-methylenetetrahydrofolate (mthf) as a co-substrate. the crystal structures of thymidylate synthase from kshv (apo), compl ... | 2016 | 27936107 |
| kshv strategies for host dsdna sensing machinery. | the innate immune system utilizes pattern recognition receptors cyclic gmp-amp synthase (cgas) to sense cytosolic double-stranded (ds) dna and initiate type 1 interferon signaling and autophagy pathway, which collaborate to limit pathogen infections as well as alarm the adaptive immune response. the genomes of herpesviruses are large dsdna, which represent a major class of pathogen signatures recognized by cellular dna sensor cgas. however, to successfully establish the persistent infection, her ... | 2016 | 27933565 |
| kaposi's sarcoma-associated herpesvirus infection of neurons in hiv-positive patients. | kaposi's sarcoma-associated herpesvirus (kshv) is the causative agent of kaposi sarcoma (ks), one of the leading cancers in human immunodeficiency virus (hiv)-infected patients in zambia. kshv was detected in the human central nervous system (cns) by polymerase chain reaction (pcr) analysis, but tissue location and cell tropism for kshv infection has not been established. given the neurotropism exhibited by other herpesviruses and the frequent coinfection of hiv-positive individuals by kshv, we ... | 2017 | 27932611 |
| expression of the antisense-to-latency transcript long noncoding rna in kaposi's sarcoma-associated herpesvirus. | the regulation of latency is central to herpesvirus biology. recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the kaposi's sarcoma-associated herpesvirus (kshv) genome and postulated the existence of multiple viral long noncoding rnas (lncrnas). next-generation sequencing studies are highly dependent on the specific experimental approach and particular algorithms of analysis and therefore benefit from independent confirmation of the r ... | 2017 | 27928018 |
| possible mechanisms of acquisition of herpesvirus virokines. | the genomes of certain types of human and primate herpesviruses contain functional homologs of important host cytokines (il-6, il-17, and il-10), or so-called virokines. virokines can interact with immune cell receptors, transmit a signal to them, and thus switch the type of immune response that facilitates viral infection development. in this work, we have summarized possible ways of virokine origin and proposed an evolutionary scenario of virokine acquisition with involvement of retroviral coi ... | 2016 | 27914460 |
| genotypic distribution of hhv-8 in aids individuals without and with kaposi sarcoma: is genotype b associated with better prognosis of aids-ks? | aids-associated kaposi's sarcoma (aids-ks) caused by human herpes virus 8 (hhv-8) is the most severe and resistant form of ks tumor. our aim was to verify whether there is an association between hhv-8 variability and development of aids-ks in brazil by comparing the hhv-8 variability between individuals without and with ks. saliva samples and blood, when available, were analyzed by polymerase chain reaction (pcr) techniques for detection of the fragments of orf k1 of hhv-8, which were then genot ... | 2016 | 27902590 |
| is there any association between sarcoidosis and infectious agents?: a systematic review and meta-analysis. | during the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. with the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. | 2016 | 27894280 |
| azidothymidine sensitizes primary effusion lymphoma cells to kaposi sarcoma-associated herpesvirus-specific cd4+ t cell control and inhibits virf3 function. | kaposi sarcoma-associated herpesvirus (kshv) is linked with the development of kaposi sarcoma and the b lymphocyte disorders primary effusion lymphoma (pel) and multi-centric castleman disease. t cell immunity limits kshv infection and disease, however the virus employs multiple mechanisms to inhibit efficient control by these effectors. thus kshv-specific cd4+ t cells poorly recognize most pel cells and even where they can, they are unable to kill them. to make kshv-infected cells more sensitiv ... | 2016 | 27893813 |
| virus-mediated alterations in mirna factors and degradation of viral mirnas by mcpip1. | kaposi's sarcoma-associated herpesvirus (kshv), the causative agent of kaposi's sarcoma, encodes 25 mature viral mirnas. mcp-1-induced protein-1 (mcpip1), a critical regulator of immune homeostasis, has been shown to suppress mirna biosynthesis via cleavage of precursor mirnas through its rnase domain. we demonstrate that mcpip1 can directly cleave kshv and ebv precursor mirnas and that mcpip1 expression is repressed following de novo kshv infection. in addition, repression with sirnas to mcpip1 ... | 2016 | 27893764 |
| recapitulation of acquired immuno deficiency syndrome associated kaposi's sarcoma. | acquired immuno deficiency syndrome (aids) associated kaposi's sarcoma (ks) is one of the clinical forms of ks. ks is caused by human herpes viruses 8 or ks associated herpes virus (kshv). in india, till now, only 16 cases of aids associated ks was reported. of all the clinical forms of ks, aids associated ks is distinct in many ways viz.; cutaneous manifestations commonly affects face and trunk rather than lower limbs, more mucosal lesions, rapidly progressive, and early systemic involvement. w ... | 2017 | 27890943 |
| ebv-associated but hhv8-unrelated double-hit effusion-based lymphoma. | effusion-based lymphoma is a rare and unique type of large b-cell lymphoma presenting in effusion without a mass lesion. it shares many clinicopathological features with primary effusion lymphoma (pel), but is distinct from pel by the absence of hhv8 association. double hit lymphoma (dhl) is an aggressive b-cell lymphoma, defined by concurrent rearrangement of myc and bcl2 or bcl6. dhl often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. here we report a 61-yea ... | 2017 | 27888664 |
| regulation of wnt/β-catenin signaling by herpesviruses. | the wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. it is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. many herpesviruses establish latency in progenitor cells and viral reactivation is linke ... | 2016 | 27878101 |
| pulmonary kaposi sarcoma: an uncommon cause of respiratory failure in the era of highly active antiretroviral therapy-case report and review of the literature. | kaposi sarcoma (ks) is the most common malignancy associated with acquired immune deficiency syndrome (aids) and is caused by human herpesvirus 8 (hhv 8) or kaposi sarcoma herpesvirus (kshv). in about 90% of cases kaposi sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. in the era of highly active antiretroviral therapy (haart), the incidence of ks has declined. clinical features of pulmonary ks might be difficult to disting ... | 2016 | 27872774 |
| viral inhibition of prr-mediated innate immune response: learning from kshv evasion strategies. | the innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. to successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (prrs) which detect conserved viral signatures and trigger the production of type i interferon (ifn) and pro-inflammatory cytokines to mediate viral clearance. viral persistence requires that viruses co-opt cellular pathways and activities ... | 2016 | 27871174 |
| high prevalence of human herpesvirus 8 infection in diabetes type 2 patients and detection of a new virus subtype. | the prevalence of human herpesvirus 8 (hhv8) dna and antiviral antibodies in diabetes type 2 (dm2) and control subjects was studied, in order to confirm a possible link between dm2 and hhv8 infection. the hhv8-dna from diabetic patients was typed for detecting possible genomic differences with known hhv8 reference viruses.dm2 patients and healthy controls were examined for the presence of hhv8 dna into the peripheral blood lymphocytes. both anti-lytic and latent phase antibodies were detected in ... | 2016 | 27864801 |
| pomalidomide for symptomatic kaposi's sarcoma in people with and without hiv infection: a phase i/ii study. | purpose kaposi's sarcoma (ks) is a multicentric tumor caused by kaposi's sarcoma-associated herpesvirus. unmet needs include therapies that are oral, anthracycline sparing, and deliverable in resource-limited settings. we evaluated pomalidomide, an oral immune modulatory agent, in patients with symptomatic ks. methods the primary objectives were to assess tolerability, pharmacokinetics, and activity. initial dosage level was 5 mg once per day for 21 days per 28-day cycle, with a de-escalated lev ... | 2016 | 27863194 |
| correction: genipin enhances kaposi's sarcoma-associated herpesvirus genome maintenance. | [this corrects the article doi: 10.1371/journal.pone.0163693.]. | 2016 | 27861579 |
| clinical characteristics and survival outcome of primary effusion lymphoma: a review of 105 patients. | primary effusion lymphoma (pel) is a rare and an aggressive b-cell non-hodgkin lymphoma with a distinctive clinicobiological features. as a result of the rarity of this malignancy, the overwhelming majority of data come from a case reports or series. our study aimed to evaluate the clinical features and the survival outcomes of 105 patients with pel who diagnosed between 2001 and 2012 from the surveillance epidemiology and end results database 18 of the us national cancer institute. the kaplan-m ... | 2016 | 27859456 |
| kshv entry and trafficking in target cells-hijacking of cell signal pathways, actin and membrane dynamics. | kaposi's sarcoma associated herpesvirus (kshv) is etiologically associated with human endothelial cell hyperplastic kaposi's sarcoma and b-cell primary effusion lymphoma. kshv infection of adherent endothelial and fibroblast cells are used as in vitro models for infection and kshv enters these cells by host membrane bleb and actin mediated macropinocytosis or clathrin endocytosis pathways, respectively. infection in endothelial and fibroblast cells is initiated by the interactions between multip ... | 2016 | 27854239 |
| proliferation status defines functional properties of endothelial cells. | homeostasis of solid tissue is characterized by a low proliferative activity of differentiated cells while special conditions like tissue damage induce regeneration and proliferation. for some cell types it has been shown that various tissue-specific functions are missing in the proliferating state, raising the possibility that their proliferation is not compatible with a fully differentiated state. while endothelial cells are important players in regenerating tissue as well as in the vasculariz ... | 2017 | 27853834 |
| kaposi's sarcoma-associated herpesvirus micrornas target gadd45b to protect infected cells from cell cycle arrest and apoptosis. | kaposi's sarcoma is one of the most common malignancies in hiv-infected individuals. the responsible agent, kaposi's sarcoma-associated herpesvirus (kshv; hhv8), expresses multiple micrornas (mirnas), but the targets and functions of these mirnas are not completely understood. after infection in primary endothelial cells with kshv, growth arrest dna damage-inducible gene 45 beta (gadd45b) is one of the most repressed genes using genomic expression profiling. gadd45b was also repressed in mrna ex ... | 2017 | 27852859 |
| amino acids essential for the interaction between cellular heat shock protein 90 and a kaposi's sarcoma-associated herpesvirus-encoded protein kinase orf36. | 2016 | 27838882 | |
| regulation of the viral life cycle by murine gammaherpesvirus 68 micrornas. | γ-herpesviruses (γhv) such as epstein-barr virus and kaposi's sarcoma-associated herpesvirus are important human pathogens involved in lymphoproliferation and tumorigenesis. murine gammaherpesvirus 68 (mhv-68, γhv-68) is an effective model for the study of γhv pathogenesis and host-virus interaction because it is closely related to human γhv. similarly to human γhv, mhv-68 encodes 15 micrornas (mirnas). although their functions remain unknown, they are thought to regulate the viral life cycle or ... | 2017 | 27837274 |
| a herpesvirus protein selectively inhibits cellular mrna nuclear export. | nuclear mrna export is highly regulated to ensure accurate cellular gene expression. viral inhibition of cellular mrna export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. we report that orf10 of kaposi's sarcoma-associated herpesvirus (kshv), a nuclear dna virus, inhibits mrna export in a transcript-selective manner to control cellular gene expression. nuclear export inhibition by orf10 requi ... | 2016 | 27832591 |
| oncogenic role of tumor viruses in humans. | viruses are the intracellular pathogens that reproduce only in the living cell and manipulate the cellular machinery to produce more viruses. viral replications can affect cellular genes of the host in multiple cancerous ways. approximately, 20% of all human oncogenesis is caused by cancer-causing viruses known as oncoviruses. viral infection causes chronic inflammation leading to cell death, uncontrollable proliferation, and modulated expression of some of the regulatory proteins. oncogenesis i ... | 2017 | 27830995 |
| a chimeric protein composed of numa fused to the dna binding domain of lana is sufficient for the ori-p-dependent dna replication. | the kaposi's sarcoma-associated herpesvirus (kshv) genome is stably maintained in kshv-infected pel cell lines during cell division. we previously showed that accumulation of lana in the nuclear matrix fraction could be important for the latent dna replication, and that the functional significance of lana should be its recruitment of ori-p to the nuclear matrix. here, we investigated whether the forced localization of the lana-dna binding domain (dbd) to the nuclear matrix facilitated ori-p-cont ... | 2017 | 27829174 |
| the kshv k1 protein modulates ampk function to enhance cell survival. | kaposi's sarcoma herpesvirus (kshv) is the etiologic agent of kaposi's sarcoma (ks) as well as two lymphoproliferative diseases, primary effusion lymphoma and multicentric castleman's disease. kshv encodes viral proteins, such as k1, that alter signaling pathways involved in cell survival. expression of k1 has been reported to transform rodent fibroblasts, and k1 transgenic mice develop multiple tumors, suggesting that k1 has an important role in kshv pathogenesis. we found that cells infected w ... | 2016 | 27829024 |
| structure of the open reading frame 49 protein encoded by kaposi's sarcoma-associated herpesvirus. | herpesviruses alternate between the latent and the lytic life cycle. switching into the lytic life cycle is important for herpesviral replication and disease pathogenesis. activation of a transcription factor replication and transcription activator (rta) has been demonstrated to govern this switch in kaposi's sarcoma-associated herpesvirus (kshv). the protein encoded by open reading frame 49 from kshv (orf49kshv) has been shown to upregulate lytic replication in kshv by enhancing the activities ... | 2017 | 27807232 |
| targeting the atp-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach. | human herpesviruses are responsible for a range of debilitating acute and recurrent diseases, including a number of malignancies. current treatments are limited to targeting the herpesvirus dna polymerases, but with emerging viral resistance and little efficacy against the oncogenic herpesviruses, there is an urgent need for new antiviral strategies. here, we describe a mechanism to inhibit the replication of the oncogenic herpesvirus kaposi's sarcoma-associated herpesvirus (kshv), by targeting ... | 2016 | 27798559 |
| p120-catenin regulates ve-cadherin endocytosis and degradation induced by the kaposi sarcoma-associated ubiquitin ligase k5. | vascular endothelial (ve)-cadherin undergoes constitutive internalization driven by a unique endocytic motif that also serves as a p120-catenin (p120) binding site. p120 binding masks the motif, stabilizing the cadherin at cell junctions. this mechanism allows constitutive ve-cadherin endocytosis and recycling to contribute to adherens junction dynamics without resulting in junction disassembly. here we identify an additional motif that drives ve-cadherin endocytosis and pathological junction di ... | 2017 | 27798235 |
| latent kaposi's sarcoma-associated herpesvirus infection in bladder cancer cells promotes drug resistance by reducing reactive oxygen species. | kaposi's sarcoma-associated herpesvirus (kshv) is the major etiologic agent of kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. recent studies have indicated that kshv can be detected at high frequency in patient-derived bladder cancer tissue and might be associated with the pathogenesis of bladder cancer. bladder cancer is the second most common cancer of the genitourinary tract, and it has a high rate of recurrence. because drug resistance is closely related t ... | 2016 | 27796928 |
| identification of novel kaposi's sarcoma-associated herpesvirus orf50 transcripts: discovery of new rta isoforms with variable transactivation potential. | kaposi's sarcoma-associated herpesvirus (kshv) is a gammaherpesvirus that has been associated with primary effusion lymphoma and multicentric castleman's disease, as well as its namesake kaposi's sarcoma. as a gammaherpesvirus, kshv is able to acutely replicate, enter latency, and reactivate from this latent state. a key protein involved in both acute replication and reactivation from latency is the replication and transcriptional activator (rta) encoded by the gene orf50 rta is a known transact ... | 2017 | 27795414 |
| [historical review of kaposi sarcoma in pre-haart era: evolution with different chemotherapy schedules and remission with ganciclovir use]. | ganciclovir has shown in vitro anti-human herpesvirus-8 activity, kaposi sarcoma agent. we analyzed all kaposi sarcoma patients from 1985 to 1996 pre-haart era and identified kaposi sarcoma/aids patients who achieved complete remission prior to haart use. | 2016 | 27792721 |
| durable remission of both multicentric castleman's disease and kaposi's sarcoma with valganciclovir, rituximab and liposomal doxorubicin in an hhv-8-positive, hiv-negative patient. | human herpesvirus-8 (hhv-8)-positive, hiv-negative multicentric castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. concurrent kaposi's sarcoma, another hhv-8-related disease, is uncommon in hiv-negative patients. the role of antiviral therapy and rituximab in hiv-negative patients is not well established. | 2017 | 27790727 |
| alterations in acetylation of histone h4 lysine 8 and trimethylation of lysine 20 associated with lytic gene promoters during kaposi's sarcoma-associated herpesvirus reactivation. | kaposi's sarcoma-associated herpesvirus (kshv) is associated with formation of kaposi's sarcoma, multicentric castleman's disease and primary effusion lymphoma. replication and transcription activator (rta) genes are expressed upon reactivation of kshv, which displays a biphasic life cycle consisting of latent and lytic replication phases. rta protein expression results in kshv genome amplification and successive viral lytic gene expression. transcriptional activity of viral lytic genes is regul ... | 2016 | 27780949 |
| oncogenic γ herpesviruses ebv and hhv8 in kidney transplantation. | epstein-barr virus (ebv) and human herpesvirus-8 (hhv-8) are γ herpesviruses associated with post-transplant malignancies in kidney transplant recipients. ebv is associated with post-transplantation lymphoproliferative disorder (ptld), with increased risk in ebv-seronegative patients on intensified immunosuppression. human herpesvirus-8 is associated with kaposi's sarcoma (ks), with an increased risk in certain patient populations. diagnosis of ptld and ks relies on tissue biopsy. the mainstay o ... | 2016 | 27772621 |
| castleman's disease of the spleen. | castleman's disease (cd), also known as giant or angiofolicular lymphoid hyperplasia or lymphoid hamartoma, is a group of atypical lymphoproliferative disorders that share common lymph node histological features and may be localized either to a single lymph node (unicentric) or occur systemically (multicentric). | 2016 | 27771992 |
| high seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in shanghai, china. | men who have sex with men (msm) are an important risk group for human immunodeficiency virus (hiv) and at high-risk of herpesvirus infection. however, limited information on epidemiologic patterns of hhv8 and hsv2 among msm is available in mainland china. a cross-sectional study of 486 participants was performed in shanghai, china from january 2013 to december 2014 to explore epidemiologic features of hhv8 and hsv2 among msm. serum samples were collected and tested for hhv8 by immunofluoresence ... | 2017 | 27769110 |
| histone h2b-ifi16 recognition of nuclear herpesviral genome induces cytoplasmic interferon-β responses. | ifi16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response dna sensor and induces the il-1β and antiviral type-1 interferon-β (ifn-β) cytokines. we have shown that ifi16, in association with brca1, functions as a sequence independent nuclear sensor of episomal dsdna genomes of kshv, ebv and hsv-1. recognition of these herpesvirus genomes resulted in ifi16 acetylation, brca1-ifi16-asc-procaspas ... | 2016 | 27764250 |
| escrt-i protein tsg101 plays a role in the post-macropinocytic trafficking and infection of endothelial cells by kaposi's sarcoma-associated herpesvirus. | kaposi's sarcoma-associated herpesvirus (kshv) binding to the endothelial cell surface heparan sulfate is followed by sequential interactions with α3β1, αvβ3 and αvβ5 integrins and ephrin a2 receptor tyrosine kinase (epha2r). these interactions activate host cell pre-existing fak, src, pi3-k and rhogtpase signaling cascades, c-cbl mediated ubiquitination of receptors, recruitment of cib1, p130cas and crk adaptor molecules, and membrane bleb formation leading to lipid raft dependent macropinocyto ... | 2016 | 27764233 |
| fine-tuning of the kaposi's sarcoma-associated herpesvirus life cycle in neighboring cells through the rta-jag1-notch pathway. | kaposi's sarcoma (ks)-associated herpesvirus (kshv) is an oncogenic pathogen that displays latent and lytic life cycles. in ks lesions, infiltrated immune cells, secreted viral and/or cellular cytokines, and hypoxia orchestrate a chronic pro-lytic microenvironment that can promote kshv reactivation. however, only a small subset of viruses spontaneously undergoes lytic replication in this pro-lytic microenvironment while the majority remains in latency. here, we show that the expression of the no ... | 2016 | 27760204 |
| constitutive activation of t cells by γ2-herpesviral gpcr through the interaction with cellular cxcr4. | members of the herpesviral family use multiple strategies to hijack infected host cells and exploit cellular signaling for their pathogenesis and latent infection. among the most intriguing weapons in the arsenal of pathogenic herpesviruses are the constitutively active virally-encoded g protein-coupled receptors (vgpcrs). even though vgpcrs contribute to viral pathogenesis such as immune evasion and proliferative disorders, the molecular details of how vgpcrs continuously activate cellular sign ... | 2017 | 27751885 |
| incidentally detected kaposi sarcoma of adrenal gland with anaplastic features in an hiv negative patient. | kaposi sarcoma (ks), a vascular tumor caused by infection with human herpesvirus 8 (hhv8), is a systemic disease that can present with cutaneous lesions with or without visceral involvement. very few cases of ks, most of which were associated with aids, have been reported in the adrenal gland. anaplastic transformation of ks is a rare clinical presentation known as an aggressive disease with local recurrence and metastatic potential. we report here a 47-year-old hiv negative male presented with ... | 2016 | 27747121 |
| transgenic mouse models of tumor virus action. | genetically engineered mice (gems) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. this review provides an overview of seminal discoveries made through the use of gem models for human dna tumor viruses. emphasis is placed on the discoveries made in the study of human papillomaviruses, merkel cell carcinoma-associated polyomavirus, epstein-barr virus, and kaposi's ... | 2016 | 27741405 |
| genipin enhances kaposi's sarcoma-associated herpesvirus genome maintenance. | kaposi's sarcoma-associated herpesvirus (kshv) is a gammaherpesvirus that causes acute infection and establishes life-long latency. kshv causes several human cancers, including kaposi's sarcoma, an acquired immune deficiency syndrome (aids)-related form of non-hodgkin lymphoma. genipin, an aglycone derived from geniposide found in gardenia jasminoides, is known to be an excellent natural cross-linker, strong apoptosis inducer, and antiviral agent. although evidence suggests antiviral activity of ... | 2016 | 27736870 |
| human herpesvirus 8 infection contributes to a t helper 2 immune response in men from tobago with prostate cancer. | to compare the cytokine profile between human herpesvirus 8 seropositive and seronegative men with and without prostate cancer. | 2017 | 27734534 |
| sirt1-mediated downregulation of p27kip1 is essential for overcoming contact inhibition of kaposi's sarcoma-associated herpesvirus transformed cells. | kaposi's sarcoma-associated herpesvirus (kshv) is an oncogenic virus associated with kaposi's sarcoma (ks), a malignancy commonly found in aids patients. despite intensive studies in the last two decades, the mechanism of kshv-induced cellular transformation and tumorigenesis remains unclear. in this study, we found that the expression of sirt1, a metabolic sensor, was upregulated in a variety of kshv-infected cells. in a model of kshv-induced cellular transformation, sirt1 knockdown with shrnas ... | 2016 | 27708228 |
| repression of the chromatin-tethering domain of murine leukemia virus p12. | murine leukemia virus (mlv) p12, encoded within gag, binds the viral preintegration complex (pic) to the mitotic chromatin. this acts to anchor the viral pic in the nucleus as the nuclear envelope re-forms postmitosis. mutations within the p12 c terminus (p12 pm13 to pm15) block early stages in viral replication. within the p12 pm13 region (p12 60pspma65), our studies indicated that chromatin tethering was not detected when the wild-type (wt) p12 protein (m63) was expressed as a green fluorescen ... | 2016 | 27707926 |
| classic solitary kaposi sarcoma of the foot in an immunocompetent patient: a case report. | kaposi sarcoma (ks) is a tumor derived from endothelial cell lineage caused by kaposi sarcoma-associated virus or human herpesvirus-8. the authors have set forth to describe a unique presentation of the classical form of ks in a homosexual individual. the authors demonstrate that a full history and physical are important in determining how to guide treatment along with ancillary tests, which can prove vital to determine management strategy. the authors then provide a brief discussion about varia ... | 2016 | 27701130 |
| regulation of the abundance of kaposi's sarcoma-associated herpesvirus orf50 protein by oncoprotein mdm2. | the switch between latency and the lytic cycle of kaposi's sarcoma-associated herpesvirus (kshv) is controlled by the expression of virally encoded orf50 protein. thus far, the regulatory mechanism underlying the protein stability of orf50 is unknown. our earlier studies have demonstrated that a protein abundance regulatory signal (pars) at the orf50 c-terminal region modulates its protein abundance. the pars region consists of pars-i (aa 490-535) and pars-ii (aa 590-650), and mutations in eithe ... | 2016 | 27698494 |
| virf3 encoded by kaposi's sarcoma-associated herpesvirus inhibits t-cell factor-dependent transcription via a creb-binding protein-interaction motif. | kaposi's sarcoma-associated herpesvirus (kshv) is an etiological agent of kaposi's sarcoma and primary effusion lymphoma. like other herpesviruses, kshv has two distinct life cycles: latent and lytic. among kshv latent genes, viral interferon regulatory factor 3 (virf3), which shares homology with cellular irfs, is a multifunctional protein. to identify unknown functions of virf3, we performed luciferase-reporter assays in the presence of virf3. these analyses revealed that overexpression of vir ... | 2016 | 27693583 |
| altering the anti-inflammatory lipoxin microenvironment: a new insight into kaposi's sarcoma-associated herpesvirus pathogenesis. | lipoxins are host anti-inflammatory molecules that play a vital role in restoring tissue homeostasis. the efficacy of lipoxins and their analog epilipoxins in treating inflammation and its associated diseases has been well documented. kaposi's sarcoma (ks) and primary effusion lymphoma (pel) are two well-known inflammation related diseases caused by kaposi's sarcoma-associated herpesvirus (kshv). controlling inflammation is one of the strategies adopted to treat ks and pel, a primary motivation ... | 2016 | 27681120 |
| rapid multiplexed immunoassay for detection of antibodies to kaposi's sarcoma-associated herpesvirus. | diagnosis of kshv-infected individuals remains a challenge. kshv prevalence is high in several populations with high prevalence of hiv, leading to increased risk of development of kaposi's sarcoma (ks). while current assays are reliable for detecting antibodies to kshv, none are routinely utilized to identify individuals with kshv infection and thus at increased risk for ks due to assay complexity, lack of access to testing, and cost, particularly in resource-limited settings. here we describe t ... | 2017 | 27669509 |
| kaposi sarcoma herpesvirus-associated cancers and related diseases. | this review discusses the pathogenesis and recent advances in the management of kaposi sarcoma herpesvirus (kshv)-associated diseases. | 2017 | 27662501 |
| the kaposi's-sarcoma-associated herpesvirus orf35 gene product is required for efficient lytic virus reactivation. | kaposi's sarcoma-associated herpesvirus (kshv) is implicated in the etiology of several human malignancies. kshv open reading frame (orf) 35 encodes a conserved gammaherpesvirus protein with an, as yet, unknown function. employing the bacterial artificial chromosome (bac) system, we generated a recombinant viral clone that fails to express orf35 (bac16-orf35-stop) but preserves intact adjacent and overlapping reading frames. using this construct, we studied the role of this previously uncharacte ... | 2016 | 27639575 |
| manipulation of the host cell membrane by human γ-herpesviruses ebv and kshv for pathogenesis. | the cell membrane regulates many physiological processes including cellular communication, homing and metabolism. it is therefore not surprising that the composition of the host cell membrane is manipulated by intracellular pathogens. among these, the human oncogenic herpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv) exploit the host cell membrane to avoid immune surveillance and promote viral replication. accumulating evidence has shown that both ebv and k ... | 2016 | 27624182 |
| kaposi sarcoma of the eyelid as an initial manifestation of aids. | kaposi sarcoma (ks) is a multifocal systemic disease that originates in the vascular endothelium related to human herpes virus 8 (hhv-8). in the early 1980s the first series of cases of disseminated kaposi sarcoma in hiv infected patients were reported. however, with the advent of highly active antiretroviral therapy (haart) since 1997, these cases are less frequently observed by clinicians. we report the case of a 40-year-old woman, presenting with two asymptomatic purpuric nodules localized in ... | 2016 | 27617725 |
| profile of exosomal and intracellular microrna in gamma-herpesvirus-infected lymphoma cell lines. | exosomes are small vesicles released from cells, into which micrornas (mirna) are specifically sorted and accumulated. two gamma-herpesviruses, kaposi sarcoma-associated herpesvirus (kshv) and epstein-barr virus (ebv), encode mirnas in their genomes and express virus-encoded mirnas in cells and exosomes. however, there is little information about the detailed distribution of virus-encoded mirnas in cells and exosomes. in this study, we thus identified virus- and host-encoded mirnas in exosomes r ... | 2016 | 27611973 |
| lana-mediated recruitment of host polycomb repressive complexes onto the kshv genome during de novo infection. | one of the hallmarks of the latent phase of kaposi's sarcoma-associated herpesvirus (kshv) infection is the global repression of lytic viral gene expression. following de novo kshv infection, the establishment of latency involves the chromatinization of the incoming viral genomes and recruitment of the host polycomb repressive complexes (prc1 and prc2) to the promoters of lytic genes, which is accompanied by the inhibition of lytic genes. however, the mechanism of how prcs are recruited to the k ... | 2016 | 27606464 |
| role of mtor inhibitors for the control of viral infection in solid organ transplant recipients. | appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mtori) is of great interest. although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive ... | 2016 | 27600985 |
| kshv encoded lana recruits nucleosome assembly protein nap1l1 for regulating viral dna replication and transcription. | the establishment of latency is an essential for lifelong persistence and pathogenesis of kaposi's sarcoma-associated herpesvirus (kshv). latency-associated nuclear antigen (lana) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. replication-coupled nucleosome assembly is a major step in packaging the newly synthesized dna into chromatin, but the mechanism of kshv genome chromatinization post-replication is not understood. he ... | 2016 | 27599637 |
| kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy. | kaposi sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8, is the etiologic agent underlying kaposi sarcoma, primary effusion lymphoma, and multicentric castleman's disease. this human gammaherpesvirus was discovered in 1994 by drs. yuan chang and patrick moore. today, there are over five thousand publications on kshv and its associated malignancies. in this article, we review recent and ongoing developments in the kshv field, including molecular mechanisms of kshv pathogen ... | 2016 | 27584730 |
| interplay of murine gammaherpesvirus 68 with nf-kappab signaling of the host. | herpesviruses establish a chronic infection in the host characterized by intervals of lytic replication, quiescent latency, and reactivation from latency. murine gammaherpesvirus 68 (mhv68) naturally infects small rodents and has genetic and biologic parallels with the human gammaherpesviruses (ghvs), kaposi's sarcoma-associated herpesvirus and epstein-barr virus. the murine gammaherpesvirus model pathogen system provides a platform to apply cutting-edge approaches to dissect the interplay of ga ... | 2016 | 27582728 |
| kaposi's sarcoma herpesvirus genome persistence. | kaposi's sarcoma-associated herpesvirus (kshv) has an etiologic role in kaposi's sarcoma, primary effusion lymphoma, and multicentric castleman's disease. these diseases are most common in immunocompromised individuals, especially those with aids. similar to all herpesviruses, kshv infection is lifelong. kshv infection in tumor cells is primarily latent, with only a small subset of cells undergoing lytic infection. during latency, the kshv genome persists as a multiple copy, extrachromosomal epi ... | 2016 | 27570517 |
| the small noncoding rnas (sncrnas) of murine gammaherpesvirus 68 (mhv-68) are involved in regulating the latent-to-lytic switch in vivo. | the human gammaherpesviruses epstein-barr virus (ebv) and kaposi's sarcoma-associated herpesvirus (kshv), which are associated with a variety of diseases including tumors, produce various small noncoding rnas (sncrnas) such as micrornas (mirnas). like all herpesviruses, they show two stages in their life cycle: lytic replication and latency. during latency, hardly any viral proteins are expressed to avoid recognition by the immune system. thus, sncrnas might be exploited since they are less like ... | 2016 | 27561205 |
| fulminant anaplastic large cell lymphoma (alcl) concomitant with primary cytomegalovirus (cmv) infection, and human herpes virus 8 (hhv-8) infection together with epstein-barr-virus (ebv) reactivation in a patient with asymptomatic hiv-infection. | most malignant lymphomas in hiv-patients are caused by reactivation of ebv-infection. some lymphomas have a very rapid fulminant course. hhv-8 has also been reported to be a cause of lymphoma. the role of cmv in the development of lymphoma is not clear, though both cmv and hhv-8 have been reported in tissues adjacent to the tumour in burkitt lymphoma patients. here we present a patient with asymptomatic hiv infection, that contracted a primary cytomegalovirus (cmv) infection and human herpes vir ... | 2016 | 27551290 |
| a role for malt1 activity in kaposi's sarcoma-associated herpes virus latency and growth of primary effusion lymphoma. | primary effusion lymphoma (pel) is an incurable malignancy that develops in immunodeficient patients as a consequence of latent infection of b-cells with kaposi's sarcoma-associated herpes virus (kshv). malignant growth of kshv-infected b cells requires the activity of the transcription factor nuclear factor (nf)-κb, which controls maintenance of viral latency and suppression of the viral lytic program. here we show that the kshv proteins k13 and k15 promote nf-κb activation via the protease muc ... | 2017 | 27538487 |