Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25507669 |
| investigate the correlation between clinical sign and symptoms and the presence of p. gingivalis, t. denticola, and t. forsythia individually or as a "red complex" by a multiplex pcr method. | the aim of this study was to investigate the correlation between endodontic clinical signs and symptoms and the presence of porphyromonas gingivalis, treponema denticola, and tannerella forsythia or their association by multiplex polymerase chain reaction assay. | 2014 | 25506144 |
| clinical, microbial, and immune responses observed in patients with diabetes after treatment for gingivitis: a three-month randomized clinical trial. | although patients with diabetes are frequently affected by periodontitis, only a few investigations have focused on gingivitis in this at-risk population. this randomized placebo-controlled clinical trial compared the response to a gingivitis treatment protocol that combined mechanical procedures and daily use of an essential oil (eo) mouthrinse between patients with and without diabetes. | 2015 | 25494658 |
| adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (mox) in one-stage scaling and root planing (srp) in treating generalized aggressive periodontitis (gagp). | 2015 | 25469723 |
| high-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis. | the oral microbiome plays a key role for caries, periodontitis, and systemic diseases. a method for rapid, high-resolution, robust taxonomic profiling of subgingival bacterial communities for early detection of periodontitis biomarkers would therefore be a useful tool for individualized medicine. here, we used illumina sequencing of the v1-v2 and v5-v6 hypervariable regions of the 16s rrna gene. a sample stratification pipeline was developed in a pilot study of 19 individuals, 9 of whom had been ... | 2015 | 25452281 |
| electrophoresis of periodontal pathogens in poly(ethyleneoxide) solutions with uncoated capillary. | periodontitis is a prevalent inflammatory disease caused by different species of anaerobic bacteria such as porphyromonas gingivalis (p.g), treponema denticola (t.d), and tannerella forsythia (t.f). we compared the separation result of dna ladders in hydroxyethyl cellulose, poly(ethyleneoxide) (peo), and polyethylene glycol and analyzed the effect of polymer concentration, electric field, and temperature of the background electrolyte on the separation performance. results demonstrated that there ... | 2015 | 25447490 |
| subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. | this review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. it has been found that chronic periodontitis affects as much as 80% of the middle-aged population; by comparison, the prevalence of aggressive periodontitis reaches up to 1-1.5%. it is accepted that this social disease is multifactorial in etiology, but the ev ... | 2014 | 25434071 |
| detection of periodontal pathogens in the patients with aortic aneurysm. | the occurrence and development of aortic aneurysm (aa) are associated with infection. some researchers have detected the dna of periodontal pathogens in aa samples in certain populations. however, it has not been done in chinese population. the objective of this study was to evaluate the prevalence of periodontal pathogens in oral tissue samples and aneurysm samples of aa patients. | 2014 | 25430459 |
| detection rates of presumptive periodontal pathogens in subgingival plaque samples of untreated periodontitis using either four or six pooled samples. | a comparison of the detection frequency and number of periodontal pathogens in patients with aggressive or generalized, severe chronic periodontitis using a gene-probe analysis. | 2010 | 25427269 |
| bovine milk fermented with lactobacillus rhamnosus l8020 decreases the oral carriage of mutans streptococci and the burden of periodontal pathogens. | the aim of this study was to find the oral isolate of lactobacilli, which has the potential to inhibit either periodontal, cariogenic, or fungal pathogens in vitro, and to examine the effects of bovine milk fermented with the isolate on the oral carriage of cariogenic and periodontal pathogens. | 2011 | 25426790 |
| antimicrobial effect of lactobacillus reuteri on cariogenic bacteria streptococcus gordonii, streptococcus mutans, and periodontal diseases actinomyces naeslundii and tannerella forsythia. | lactic acid bacteria (lab) are well known for their beneficial effects on human health in the intestine and immune system; however, there are few studies on the impact they can generate in oral health. the aim of this study was to test and compare in vitro antimicrobial activity of l. reuteri on pathogenic bacteria involved in the formation of dental caries: s. mutans, s. gordonii, and periodontal disease: a. naeslundii and t. forsythia. also, we determined the growth kinetics of each bacterium ... | 2015 | 25422124 |
| shifts in campylobacter species abundance may reflect general microbial community shifts in periodontitis progression. | oral campylobacter species have been found to be associated with periodontitis progression. while the etiological significance of campylobacter rectus is quite established, the association of c. gracilis, c. concisus, and c. curvus with health or disease remains contradictory. | 2014 | 25412608 |
| association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. | to relate the periodontal condition with the presence of periodontal bacteria in pregnant that had babies with preterm delivery or/and low weight at birth (ptlbw). | 2016 | 25394610 |
| mirolase, a novel subtilisin-like serine protease from the periodontopathogen tannerella forsythia. | the genome of tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. here, we characterized a subtilisin-like serine protease of t. forsythia referred to as mirolase. recombinant full-length latent promirolase [85 kda, without its signal peptide (sp)] processed itself through sequential autoproteolytic cleavages into a mature enzyme of 40 kda. mirolase latency was driven by the n-terminal prodomain (ntp). in stark contrast to alm ... | 2015 | 25391881 |
| miropin, a novel bacterial serpin from the periodontopathogen tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. | all prokaryotic genes encoding putative serpins identified to date are found in environmental and commensal microorganisms, and only very few prokaryotic serpins have been investigated from a mechanistic standpoint. herein, we characterized a novel serpin (miropin) from the human pathogen tannerella forsythia, a bacterium implicated in initiation and progression of human periodontitis. in contrast to other serpins, miropin efficiently inhibited a broad range of proteases (neutrophil and pancreat ... | 2014 | 25389290 |
| prevalence of six periodontal pathogens in subgingival samples of italian patients with chronic periodontitis. | the aim of this study was to investigate the subgingival prevalence of six periodontal pathogens in 352 italian patients with chronic periodontitis. possible correlations with clinical parameters, age, gender and smoking status were also investigated. at first visit a pooled subgingival plaque sample was obtained for each subject by using the paper-point method. the samples were processed and analysed according to a commercially available quantitative real time polymerase chain reaction assay (m ... | 2014 | 25387289 |
| occurrence of socransky red complex in pregnant women with and without periodontal disease. | to verify the presence of socransky red complex (porphyromonas gingivalis, treponema denticola and tannerella forsythia) and p. intermedia using polymerase chain reaction (pcr) in periodontally healthy pregnant women and pregnant women with periodontal disease, as well as its relation to arterial blood pressure and capillary glycaemia. | 2015 | 25386627 |
| the effect of conventional mechanical periodontal treatment on red complex microorganisms and clinical parameters in down syndrome periodontitis patients: a pilot study. | periodontal disease (pd) is induced by a complex microbiota, such as porphyromonas gingivalis, tannerella forsythia, and treponema denticola (together called the red complex), which triggers intense inflammatory reaction. down syndrome (ds) individuals demonstrate a high prevalence of pd compared with those who are otherwise chromosomally normal (euploids). this pilot study aimed to evaluate the effect of non-surgical periodontal treatment in ds chronic periodontitis patients on clinical and mic ... | 2015 | 25367612 |
| evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients. | to evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis. | 2014 | 25316464 |
| role of porphyromonas gingivalis gingipains in multi-species biofilm formation. | periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic inflammatory reactions by the affected tissue. the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola are commonly found as part of the microbiota of subgingival biofilms, and they are associated with the occurren ... | 2014 | 25270662 |
| polymerase chain reaction as a prospect for the early diagnosis and prediction of periodontal diseases in adolescents. | this study was to determine the markers representative of pathogenic periodontal microflora [prevotella intermedia (p.i), tannerella forsythia (t.f) [bacteroides forsythus], treponema denticola (t.d), actinobacillus actinomycetemcomitans (a.a), porphyromonas gingivalis (p.g)] in the dental plaque of adolescents with various degrees of severity of periodontium inflammation. | 2015 | 25266040 |
| antibodies to periodontal pathogens are associated with coronary plaque remodeling but not with vulnerability or burden. | previous studies have suggested positive associations between periodontal infection and cardiovascular disease. we aimed to investigate the associations of circulating antibodies against periodontal pathogens with 1-year cardiovascular outcome, as well as the extent of coronary atherosclerosis, plaque vulnerability and lesion remodeling on intravascular ultrasound (ivus) imaging. | 2014 | 25233105 |
| association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. | polycystic ovary syndrome (pcos) is a hormonal disorder of women that not only is the leading cause of infertility but also shows a reciprocal link with oral health. this study aimed to investigate the hypothesis that the levels of putative periodontal pathogens in saliva and their antibody response in serum are elevated in pcos, compared to systemic health. a total of 125 women were included in four groups; 45 women with pcos and healthy periodontium, 35 women with pcos and gingivitis, 25 syste ... | 2014 | 25232962 |
| neutrophil mobilization by surface-glycan altered th17-skewing bacteria mitigates periodontal pathogen persistence and associated alveolar bone loss. | alveolar bone (tooth-supporting bone) erosion is a hallmark of periodontitis, an inflammatory disease that often leads to tooth loss. periodontitis is caused by a select group of pathogens that form biofilms in subgingival crevices between the gums and teeth. it is well-recognized that the periodontal pathogen porphyromonas gingivalis in these biofilms is responsible for modeling a microbial dysbiotic state, which then initiates an inflammatory response destructive to the periodontal tissues and ... | 2014 | 25225799 |
| real-time pcr quantification of six periodontal pathogens in saliva samples from healthy young adults. | the use of saliva as a diagnostic fluid for the evaluation of periodontal health has gained attention recently. most published real-time pcr assays focused on quantification of bacteria in subgingival plaque, not in saliva. the aims of this study were to develop a real-time pcr assay for quantification of six periodontal pathogens in saliva and to establish a relationship between the amount of dna (fg) and colony-forming unit (cfu). | 2015 | 25217278 |
| [comparison of the effects of ginkgo biloba extract and minocycline hydrochlovide on periodontitis]. | to compare the clinical effect of ginkgo biloba extract gel (ginkgo biloba extract,egb) and minocycline hydrochloride (periocline) on periodontitis and their inhibition on putative periodontal pathogens. | 2014 | 25199931 |
| the presence of cariogenic and periodontal pathogens in the oral cavity of one-year-old infants delivered pre-term with very low birthweights: a case control study. | recently, the dental literature has focused mainly on the microbial colonization of healthy full-term infants and their mothers or caretakers. however, oral microbial acquisition by premature infants has not been adequately investigated, and the correlation between pre-term birth and the presence of cariogenic and periodontal pathogens has not been determined. the aim of this study was to identify the presence and quantities of representative cariogenic and periodontal pathogens in the oral cavi ... | 2014 | 25178742 |
| a pathogenic trace of tannerella forsythia - shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin. | tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. however, its virulence factors, including numerous putative proteases, are mostly uncharacterized. karilysin is a newly described matrix metalloprotease-like enzyme of t. forsythia. since pathogen-derived proteases may affect the host defense system via modulation of the cytokine network, the aim of this study was to determine the influence of karilysin on tumor necrosis factor-α (tnf-α). the results s ... | 2014 | 25175980 |
| periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation. | epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. several human studies have detected bacterial dna corresponding to periodontal pathogens in cardiovascular samples. intraplaque hemorrhage has been associated with a higher risk of atherosclerotic plaque rupture, potentially mediated by neutrophil activation. in this study, we hypothesized that plaque composition may be related to periodontal pathogens. | 2014 | 25173070 |
| comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease. | polymicrobial diseases are caused by combinations of multiple bacteria, which can lead to not only mild but also life-threatening illnesses. periodontitis represents a polymicrobial disease; porphyromonas gingivalis, treponema denticola and tannerella forsythia, called 'the red complex', have been recognized as the causative agents of periodontitis. although molecular interactions among the three species could be responsible for progression of periodontitis, the relevant genetic mechanisms are u ... | 2014 | 25171331 |
| dentilisin involvement in coaggregation between treponema denticola and tannerella forsythia. | periodontitis arises from a biofilm consisting of gram-negative anaerobic rods and spirochetes. porphyromonas gingivalis, treponema denticola, and tannerella forsythia, termed the red complex, have been co-isolated with high frequency from chronic periodontitis lesions, and these microorganisms are thought to be major pathogens of the disease. coaggregation is an important strategy in the colonization of dental plaque biofilm by these bacteria. in the present study, we investigated the coaggrega ... | 2014 | 25152229 |
| microbial signature profiles of periodontally healthy and diseased patients. | to determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. | 2014 | 25139407 |
| periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives. | periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and the success of antiresorptive treatments will rely on how effectively they can ameliorate periodontal disease-induced oxidative stress during oral infection. | 2015 | 25101489 |
| reducing the bioactivity of tannerella forsythia lipopolysaccharide by porphyromonas gingivalis. | tannerella forsythia is considered a pathogen of periodontitis and forms a biofilm with multi-species bacteria in oral cavity. lipopolysaccharide is a powerful immunostimulator and induces inflammation and shock. the purpose of this study was to investigate the characteristics of t. forsythia lps in its co-cultivation with fusobacterium nucleatum or porphyromonas gingivalis. t. forsythia was co-cultured in the presence and absence of f. nucleatum and p. gingivalis and then t. forsythia lps was e ... | 2014 | 25098564 |
| igg sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross-sectional study of selected pocket sites. | to evaluate the association among serum immunoglobulin g (igg) responses to aggregatibacter actinomycetemcomitans (aa) serotypes a, b and c, porphyromonas gingivalis (pg), tannerella forsythia (tf) and clinical parameters in aggressive periodontitis (ap) subjects. associations between periodontal pathogens and clinical and immunological parameters were also evaluated. | 2014 | 25070874 |
| periodontopathogens and human β-defensin-2 expression in gingival crevicular fluid from patients with periodontal disease in guangxi, china. | periodontal diseases are often induced by periodontopathogens, which are always exposed to certain innate immune factors in gingival crevicular fluid, including human β-defensin-2 (hbd-2). this study aims to investigate the relationship among periodontopathogens, clinical parameters and hbd-2 expression. | 2015 | 25065393 |
| active invasion of porphyromonas gingivalis and infection-induced complement activation in apoe-/- mice brains. | periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of alzheimer's disease. apoe-/- mice were orally infected (n = 12) with porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum as mono- and polymicrobial infections. apoe-/- mice were sacrificed following 12 and 24 weeks of chronic infection. bacterial gen ... | 2015 | 25061055 |
| effect of repeated adjunctive antimicrobial photodynamic therapy on subgingival periodontal pathogens in the treatment of chronic periodontitis. | the aim of this study was to compare the effect of subgingival ultrasonic scaling followed by repeated (three times) antimicrobial photodynamic therapy (pdt), ultrasonic scaling alone (us), and scaling and root planing with hand instruments (srp) for initial periodontal treatment. twenty-seven non-smoking systemically healthy chronic periodontitis patients were included. residual pockets ≥4 mm deep and bleeding on probing were debrided either with srp, us alone, or us followed by a single episod ... | 2015 | 25056413 |
| bioinformatic investigation of the cost management strategies of five oral microbes. | some amino acids are more energetically costly to synthesize de novo, therefore many microbes have evolved to regulate the metabolic expenditure of the cell and reduce the energy burden of extracellular unrecyclable proteins. several oral bacterial species take up amino acids and peptides obtained from proteolysis of host proteins and hence do not rely only on de novo synthesis. the aim of this study was to investigate if five oral bacterial species implement cost management strategies to reduce ... | 2015 | 25052707 |
| quantitative analysis of classical and new putative periodontal pathogens in subgingival biofilm: a case-control study. | a number of species/phylotypes have been newly implicated as putative periopathogens. the objective of this study was to explore associations among classical and new pathogens in subgingival biofilm and to assess their relative importance to chronic periodontitis. | 2015 | 25040261 |
| lack of a surface layer in tannerella forsythia mutants deficient in the type ix secretion system. | tannerella forsythia, a gram-negative anaerobic bacterium, is an important pathogen in periodontal disease. this bacterium possesses genes encoding all known components of the type ix secretion system (t9ss). t. forsythia mutants deficient in genes orthologous to the t9ss-encoding genes pork, port and sov were constructed. all pork, port and sov single mutants lacked the surface layer (s-layer) and expressed less-glycosylated versions of the s-layer glycoproteins tfsa and tfsb. in addition, thes ... | 2014 | 25023245 |
| influence of the periodontal status on the initial-biofilm formation on titanium surfaces. | dental implants will be exposed to a complex ecosystem once they are placed in the oral cavity. the bacterial colonization and biofilm formation on these devices will depend not only on the physicochemical surface implant properties but also on the periodontal health conditions of the patients, as these devices are exposed. | 2016 | 24995517 |
| glycobiology aspects of the periodontal pathogen tannerella forsythia. | glycobiology is important for the periodontal pathogen tannerella forsythia, affecting the bacterium's cellular integrity, its life-style, and virulence potential. the bacterium possesses a unique gram-negative cell envelope with a glycosylated surface (s-) layer as outermost decoration that is proposed to be anchored via a rough lipopolysaccharide. the s-layer glycan has the structure 4‑meo-b-manpnacconh2-(1→3)-[pse5am7gc-(2→4)-]-b-manpnaca-(1→4)-[4-meo-a-galp-(1→2)-]-a-fucp-(1→4)-[-a-xylp-(1→3 ... | 2012 | 24970146 |
| identification of microbial pathogens in periodontal disease and diabetic patients of south indian population. | periodontitis have been referred to as the sixth complication of diabetes found in high prevalence among diabetic patients than among healthy controls. the aim of the present study was to examine the periodontal disease status among collected dental plaque samples. chromosomal dna was isolated and amplified by universal primers. the dna was sequenced for bacterial confirmation and phylogenetic analysis performed for the evolutionary relationship with other known pathogens. no amplification produ ... | 2014 | 24966528 |
| colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria. | biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola). | 2014 | 24949828 |
| oral inflammation, tooth loss, risk factors, and association with progression of alzheimer's disease. | periodontitis is a polymicrobial chronic inflammatory disease of tooth-supporting tissues with bacterial etiology affecting all age groups, becoming chronic in a subgroup of older individuals. periodontal pathogens porphyromonas gingivalis, tannerella forsythia, and treponema denticola are implicated in the development of a number of inflammatory pathologies at remote organ sites, including alzheimer's disease (ad). the initial inflammatory hypothesis proposed that ad hallmark proteins were the ... | 2014 | 24946875 |
| the influence of orthodontic fixed appliances on the oral microbiota: a systematic review. | to investigate whether there is scientific evidence to support the hypothesis that the presence of orthodontic fixed appliances influences the oral microbiota. | 2014 | 24945514 |
| antibacterial activities of extracts from ugandan medicinal plants used for oral care. | medicinal plants are widely used for treatment of oral/dental diseases in uganda. | 2014 | 24945400 |
| periodontal pathogens in atheromatous plaque. | there has been increasing attention paid in recent years to the possibility that oral bacterial infection, particularly periodontal disease may influence the initiation and or progression of systemic diseases. these studies confirm the observation that heart disease is the most commonly found systemic condition in patients with periodontal disease. moreover, the literature has also highlighted substantial evidence indicating the presence of gram-negative periodontal pathogens in atheromatous pla ... | 2014 | 24943760 |
| the s-layer proteins of tannerella forsythia are secreted via a type ix secretion system that is decoupled from protein o-glycosylation. | conserved c-terminal domains (ctd) have been shown to act as a signal for the translocation of certain proteins across the outer membrane of bacteroidetes via a type ix secretion system (t9ss). the genome sequence of the periodontal pathogen tannerella forsythia predicts the presence of the components for a t9ss in conjunction with a suite of ctd proteins. t. forsythia is covered with a two-dimensional crystalline surface (s-) layer composed of the glycosylated ctd proteins tfsa and tfsb. to inv ... | 2014 | 24943676 |
| expression and regulation of triggering receptor expressed on myeloid cells 1 in periodontal diseases. | periodontitis is an inflammatory infectious disease that destroys the tooth-supporting tissues. it is caused by multi-species subgingival biofilms that colonize the tooth surface. porphyromonas gingivalis, treponema denticola and tannerella forsythia (i.e. 'red complex' bacteria) are characteristic subgingival biofilm species. the triggering receptor expressed on myeloid cells 1 (trem-1) is a cell surface receptor of the immunoglobulin superfamily, with a role in the amplification of proinflamma ... | 2014 | 24924298 |
| association between periodontal disease and plasma levels of cholesterol and triglycerides. | untreated periodontal disease seems to cause low grade systemic inflammation and blood lipid alteration leading to increased cardiovascular disease risk. to start testing this hypothesis in colombian patients, a multicentre study was conducted including the three main state capitals: bogota, medellin and cali. | 2013 | 24892452 |
| [effect of er:yag laser on the dynamic changes in subgingival flora in type 2 diabetic patients with periodontitis]. | to observe the changes in subgingival microflora before and after er:yag laser treatment on diabetic patients with periodontitis, and to compare with the subgingival microflora of chronic periodontitis. | 2014 | 24881214 |
| comparison of culture and polymerase chain reaction techniques in the identification of tannerella forsythia in periodontal health and disease, an in vitro study. | various bacterial species from subgingival biofilm have demonstrated aetiological relevance in the initiation and progression of periodontitis. the aim of this study was to detect the presence of tannerella forsythia (tf) in subgingival plaque of periodontally healthy subjects and chronic periodontitis patients by using both culture and pcr technique and compare the two techniques. | 2014 | 24872621 |
| internal bacterial colonization of implants: association with peri-implant bone loss. | the aim of the present longitudinal study was to investigate bacterial colonization of the internal implant cavity and to evaluate a possible association with peri-implant bone loss. | 2015 | 24861845 |
| clinical and microbiological characterization of localized aggressive periodontitis: a cohort study. | localized aggressive periodontitis (lagp) is an infectious periodontal disease which generally affects young people. recent data suggest the involvement of different bacterial species in different populations. the causative bacterial species in israel has never been identified despite a high prevalence of lagp in this population. the objectives of this study were to characterize the bacterial microbiota of periodontal pockets within an israeli lagp population who were also clinically assessed. | 2014 | 24861390 |
| evaluation of periodontal pathogens of the mandibular third molar pericoronitis by using real time pcr. | the aim of this study was to investigate the mandibular third molar pericoronitis flora by using real-time polymerase chain reaction (pcr). | 2014 | 24835305 |
| relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque. | human beta-defensins (hbds) are a group of antimicrobial peptides important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. the aim of this study was to explore relationships among hbds, total subgingival bacteria and periodontopathogens in healthy subjects and in patients with chronic periodontitis. | 2015 | 24814979 |
| epstein-barr virus associated peri-implantitis: a split-mouth study. | herpesviral-bacterial synergism may play a potential role in periodontitis and peri-implantitis (pi) etiopathogenesis. pi lesions can worsen depending on specific microbial challenge and host susceptibility. this cross-sectional split-mouth study aimed to substantiate herpesviral-bacterial co-infection in pi patients and assess associations with periodontopathogen salivary contamination. | 2015 | 24802631 |
| detection and quantification of periodontal pathogens in smokers and never-smokers with chronic periodontitis by real-time polymerase chain reaction. | the purpose of the present investigation is to compare the presence and number of periodontal pathogens in the subgingival microbiota of smokers versus never-smokers with chronic periodontitis and matched probing depths (pds) using real-time polymerase chain reaction (rt-pcr). | 2014 | 24794687 |
| porphyromonas gingivalis: major periodontopathic pathogen overview. | porphyromonas gingivalis is a gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. this anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. the purpose of this review is to provide an overview ... | 2014 | 24741603 |
| genetic characteristics and pathogenic mechanisms of periodontal pathogens. | periodontal disease is caused by a group of bacteria that utilize a variety of strategies and molecular mechanisms to evade or overcome host defenses. recent research has uncovered new evidence illuminating interesting aspects of the virulence of these bacteria and their genomic variability. this paper summarizes some of the strategies utilized by the major species - aggregatibacter actinomycetemcomitans, tannerella forsythia, treponema denticola, and porphyromonas gingivalis - implicated in the ... | 2014 | 24736700 |
| assessment of periodontal and opportunistic flora in patients with peri-implantitis. | to assess the presence of periodontal and opportunistic organisms in patients with peri-implantitis. | 2015 | 24720498 |
| periodontal pathogens and associated factors in aggressive periodontitis: results 5-17 years after active periodontal therapy. | to assess the association between presence of periodontal pathogens and recurrence of disease in patients with aggressive periodontitis (agp) after active periodontal therapy (apt) and further influencing factors. | 2014 | 24708362 |
| [clinical and microbiological effects of the initial periodontal therapy]. | periodontitis is a destructive inflammatory disease of the tooth-supporting tissues, primarily caused by gram-negative microorganisms. thus, the primary objective of cause-related initial periodontal therapy is disruption and removal of the subgingival biofilm. | 2014 | 24684025 |
| presence of oral bacterial species in primary endodontic infections of primary teeth. | knowledge of the microbial composition of deciduous endodontic infections is limited. this study aimed to evaluate the presence of the 10 oral bacterial species in samples from primary tooth root canals by using microarray technology and to determine the association of these organisms with clinical conditions. | 2013 | 24683780 |
| oral cavity anaerobic pathogens in biofilm formation on voice prostheses. | a polymerase chain reaction (pcr)-based method has been used to identify oral anaerobic pathogens in biofilms on voice prostheses. the purpose of the present study was to determine the location of those pathogens inside the biofilms. | 2015 | 24677258 |
| ancient human oral plaque preserves a wealth of biological data. | a new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. the authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins. | 2014 | 24675519 |
| microbiological assessment of the implant-abutment interface in different connections: cross-sectional study after 5 years of functional loading. | to evaluate the bacterial microflora present inside the implant connection and in the peri-implant sulcus fluid of healthy implants, and to analyze the relationships between these harboring sites for four different implant systems after at least 5 years of functional loading. | 2015 | 24665919 |
| bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitis. | periodontal diseases are multifactorial, caused by polymicrobial subgingival pathogens, including porphyromonas gingivalis, treponema denticola, and tannerella forsythia. chronic periodontal infection results in inflammation, destruction of connective tissues, periodontal ligament, and alveolar bone resorption, and ultimately tooth loss. enoxacin and a bisphosphonate derivative of enoxacin (bis-enoxacin) inhibit osteoclast formation and bone resorption and also contain antibiotic properties. our ... | 2014 | 24638087 |
| bacteria community study of combined periodontal-endodontic lesions using denaturing gradient gel electrophoresis and sequencing analysis. | the entire microbial population and predominant microflora of root canals (rcs) and adjacent periodontal pockets (pps) from teeth with combined periodontal-endodontic lesions were determined and compared. | 2014 | 24579762 |
| clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. | the aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (lfx) as an adjunct to scaling and root planing (srp) in patients with chronic periodontitis (cp). | 2015 | 24574052 |
| pathogens and host immunity in the ancient human oral cavity. | calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. we report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. we characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ... | 2014 | 24562188 |
| [dissertations 25 years after date 37. susceptibility to periodontal diseases]. | in the eighties of the former century it was observed that individuals had different modes of development of periodontitis, largely for unknown reasons. it was assumed that periodontal disease developed as a result of the presence of virulent micro-organisms in combination with an inadequate host response. the concept of this (im)balance in host parasite interactions developed further, in part because of new research techniques. with respect to oral bacteria it was shown that periodontal pathoge ... | 2013 | 24555252 |
| prevelance of periodontopathogenic bacteria in subgingival biofilm and atherosclerotic plaques of patients undergoing coronary revascularization surgery. | the objective of the present study was to detect the presence of specific periodontopathogenic bacteria in the coronary plaque of patients with coronary artery disease and to find out the significant association between the periodontal status and the presence of pathogenic bacteria in the coronary plaque. | 2013 | 24554879 |
| subgingival plaque sampling after combined mechanical and antibiotic nonsurgical periodontal therapy. | this study aimed to make a comparison of two sampling strategies of subgingival plaque after combined mechanical-antibiotic periodontal therapy. | 2015 | 24554003 |
| single cell genomics of uncultured, health-associated tannerella bu063 (oral taxon 286) and comparison to the closely related pathogen tannerella forsythia. | the uncultivated bacterium tannerella bu063 (oral taxon 286) is the closest relative to the periodontal pathogen tannerella forsythia, but is not disease-associated itself. using a single cell genomics approach, we isolated 12 individual bu063 cells by flow cytometry, and we amplified and sequenced their genomes. comparative analyses of the assembled genomic scaffolds and their gene contents allowed us to study the diversity of this taxon within the oral community of a single human donor that pr ... | 2014 | 24551246 |
| transcriptional responses of treponema denticola to other oral bacterial species. | the classic organization by socransky and coworkers categorized the oral bacteria of the subgingival plaque into different complexes. treponema denticola, porphyromonas gingivalis and tannerella forsythia are grouped into the red complex that is highly correlated with periodontal disease. socransky's work closely associates red with orange complex species such as fusobacterium nucleatum and prevotella intermedia but not with members of the other complexes. while the relationship between species ... | 2014 | 24505483 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| 16s rdna-based metagenomic analysis of dental plaque and lung bacteria in patients with severe acute exacerbations of chronic obstructive pulmonary disease. | acute exacerbations of chronic obstructive pulmonary disease (ae-copd) are leading causes of mortality in hospital intensive care units. we sought to determine whether dental plaque biofilms might harbor pathogenic bacteria that can eventually cause lung infections in patients with severe ae-copd. | 2014 | 24484531 |
| in vitro-activity of oily calcium hydroxide suspension on microorganisms as well as on human alveolar osteoblasts and periodontal ligament fibroblasts. | findings from animal and human studies have indicated that an oily calcium hydroxide suspension (ochs) may improve early wound healing in the treatment of periodontitis. calcium hydroxide as the main component is well known for its antimicrobial activity, however at present the effect of ochs on the influence of periodontal wound healing/regeneration is still very limited. the purpose of this in vitro study was to investigate the effect of ochs on periodontopathogenic bacteria as well as on the ... | 2014 | 24475753 |
| in vivo effectiveness of silicone gel sheets as barriers at the inner microgap between a prosthetic abutment and an external-hexagon implant platform. | bacterial penetration and colonization of the microgap at the implant-abutment interface have been reported in several studies. the aim of this study was to evaluate the effectiveness of placing a silicone membrane between the abutment and the implant platform in an attempt to seal the interface. | 2014 | 24451862 |
| periodontal disease associated with red complex bacteria in dogs. | red complex bacteria (treponema denticola, tannerella forsythia and porphyromonas gingivalis) play a major role in the aetiology of periodontal disease in humans. this study was designed to evaluate the association of such bacteria with periodontal disease in dogs. | 2014 | 24450418 |
| the effect of locally delivered doxycycline in the treatment of chronic periodontitis. a clinical and microbiological cohort study. | to evaluate the efficacy of locally delivered doxycycline as an adjunct to non-surgical treatment with the use of an ultrasonic device compared to scaling and root planing using hand instruments, by means of clinical and microbiological criteria. | 2010 | 24421978 |
| tannerella forsythia bspa increases the risk factors for atherosclerosis in apoe(-/-) mice. | the aim of this study was to evaluate the effects of tannerella forsythia and its major surface virulence factor, bspa, on the progression of atherosclerosis in apoe(-/-) mice and the expression of lipid metabolism-related genes. | 2014 | 24372897 |
| periodontal bacteria in the genital tract: are they related to adverse pregnancy outcome? | one of the most important factors implicated in preterm birth (ptb) is acute genitourinary tract infection. the bacteria causing chronic periodontal inflammation include gram-negative rods and anaerobes similar to those found in women with bacterial vaginosis. the aim of this prospective study is to investigate the relationship between oral and vaginal microflora and preterm low birth weight. real-time polymerase chain reaction was used to detect both the presence and level of six periodontitis- ... | 2017 | 24355228 |
| structural and functional characterization of nanu, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling bacteroidetes species. | many human-dwelling bacteria acquire sialic acid for growth or surface display. we identified previously a sialic acid utilization operon in tannerella forsythia that includes a novel outer membrane sialic acid-transport system (nanou), where nano (neuraminate outer membrane permease) is a putative tonb-dependent receptor and nanu (extracellular neuraminate uptake protein) is a predicted susd family protein. using heterologous complementation of nanou genes into an escherichia coli strain devoid ... | 2014 | 24351045 |
| the effects of different orthodontic appliances upon microbial communities. | orthodontic appliances can promote accumulation of dental plaque, with associated enamel decalcification or gingival inflammation. the aim of this study was to examine longer-term microbiological changes during orthodontic treatment with fixed appliances. | 2014 | 24345204 |
| impact of early colonizers on in vitro subgingival biofilm formation. | the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ... | 2013 | 24340084 |
| interleukin-8 responses of multi-layer gingival epithelia to subgingival biofilms: role of the "red complex" species. | periodontitis is an infectious inflammatory disease that results in the destruction of the tooth-supporting (periodontal) tissues. the gram-negative anaerobic species porphyromonas gingivalis, tannerella forsythia and treponema denticola, (also known as the "red complex" species) are highly associated with subgingival biofilms at periodontitis-affected sites. a major chemokine produced by the gingival epithelium in response to biofilm challenge, is interleukin (il)-8. the aim of this in vitro st ... | 2013 | 24339946 |
| biology and pathogenesis of cytomegalovirus in periodontal disease. | human periodontitis is associated with a wide range of bacteria and viruses and with complex innate and adaptive immune responses. porphyromonas gingivalis, tannerella forsythia, aggregatibacter actinomycetemcomitans, treponema denticola, cytomegalovirus and other herpesviruses are major suspected pathogens of periodontitis, and a combined herpesvirus-bacterial periodontal infection can potentially explain major clinical features of the disease. cytomegalovirus infects periodontal macrophages an ... | 2014 | 24320955 |
| [relationships of five periodontal pathogens causing subgingival plaque in patients with chronic periodontitis under different periodontal conditions]. | this study aimed to assess the relationship between the distributions of haemophilus aggregatibacter (h. aggregatibacter ), porphyromonas gingivalis (p. gingivalis ), prevotella intermedia (p. intermedia), tannerella forsythensis (t. forsythensis), and treponema denticola (t. denticola) in subgingival plaque and different periodontal conditions of chronic periodontitis. | 2013 | 24298807 |
| the influence of oral bacteria on epithelial cell migration in vitro. | oral ulcerations often arise as a side effect from chemo- and radiation therapy. in a previous clinical study, porphyromonas gingivalis was identified as a positive predictor for oral ulcerations after hematopoetic stem cell transplantation, possibly incriminating p. gingivalis in delayed healing of the ulcerations. therefore, it was tested whether p. gingivalis and its secreted products could inhibit the migration of oral epithelial cells in an in vitro scratch assay. to compare, the oral bacte ... | 2013 | 24288439 |
| bacterial cell-envelope glycoconjugates. | prokaryotic glycosylation fulfills an important role in maintaining and protecting the structural integrity and function of the bacterial cell wall, as well as serving as a flexible adaption mechanism to evade environmental and host-induced pressure. the scope of bacterial and archaeal protein glycosylation has considerably expanded over the past decade(s), with numerous examples covering the glycosylation of flagella, pili, glycosylated enzymes, as well as surface-layer proteins. this article a ... | 2013 | 24274370 |
| oral status in patients with early rheumatoid arthritis: a prospective, case-control study. | patients with ra suffer from a higher risk of periodontal attachment loss and increased oral inflammation. we hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced ra. the primary objective of the present study was to determine whether a loss of alveolar bone can be detected in ra patients during the early course of the disease. | 2014 | 24273047 |
| association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females. | previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease. | 2013 | 24261910 |
| oral hygiene reinforcement in the simplified periodontal treatment of 1 hour. | to compare the clinical and microbiological outcome of the 1-h ultrasonic debridement of chronic periodontitis patients (cpp) with and without frequent sessions of oral hygiene reinforcement. | 2014 | 24255993 |
| microbial changes in subgingival plaque and polymicrobial intracellular flora in buccal cells after fixed orthodontic appliance therapy: a preliminary study. | the oral ecosystem is strictly related to a balance maintained by specific niches recognized as sites, where oral bacteria can metabolize avoiding the immune system response. the oral bacteria species that colonize the ecological niches vary during fixed orthodontic treatment, with a prevalence of periodontal bacterial species. qualitative analysis of five periodontal pathogens was used to investigate the microbial colonization rate in the crevice and buccal epithelial cells. the presence of ina ... | 2013 | 24223591 |
| microbiological effect of essential oils in combination with subgingival ultrasonic instrumentation and mouth rinsing in chronic periodontitis patients. | thirty chronic periodontitis patients were randomly assigned to 3 groups: control, saline, and essential oil-containing antiseptic (eo). subgingival plaque was collected from a total of 90 pockets across all subjects. subsequently, subgingival ultrasonic instrumentation (sui) was performed by using eo or saline as the irrigation agent. after continuous mouth rinsing at home with eo or saline for 7 days, subgingival plaques were sampled again. periodontopathic bacteria were quantified using the m ... | 2013 | 24171000 |
| oxantel disrupts polymicrobial biofilm development of periodontal pathogens. | bacterial pathogens commonly associated with chronic periodontitis are the spirochete treponema denticola and the gram-negative, proteolytic species porphyromonas gingivalis and tannerella forsythia. these species rely on complex anaerobic respiration of amino acids, and the anthelmintic drug oxantel has been shown to inhibit fumarate reductase (frd) activity in some pathogenic bacteria and inhibit p. gingivalis homotypic biofilm formation. here, we demonstrate that oxantel inhibited p. gingival ... | 2014 | 24165189 |