Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| high rate of hepatitis b virus infection among hairdressers in ibadan, nigeria. | hepatitis b virus (hbv) infection is a major public health problem for over two billion people infected globally. occupationally exposed persons are at high risk of hbv infection and, apart from medical personnel, there is dearth of information concerning the prevalence and awareness of hbv among this population in nigeria. this study was designed to determine the levels of hbv awareness and prevalence of hbv infection among hairdressers in ibadan, nigeria. hairdressers and teachers (unmatched c ... | 2017 | 28318369 |
| statins decrease the risk of decompensation in hbv- and hcv-related cirrhosis: a population-based study. | statin decreased the risk of decompensation and mortality in veteran patients with cirrhosis due to hepatitis c virus (hcv). whether this beneficial effect can be extended to cirrhosis in general population or cirrhosis with other causes, such as hepatitis b virus (hbv) infection and alcohol, remains unknown. statin also decreased the risk of hepatocellular carcinoma (hcc) in patients with chronic hbv and hcv infection. it is unclear whether the effect can be observed in patients already with ci ... | 2017 | 28318053 |
| nucleos(t)ide analogues for preventing hbv reactivation in immunosuppressed patients with hematological malignancies: a network meta-analysis. | we aimed to evaluate the efficacy of five oral nucleos(t)ide analogues (nas), including lamivudine, entecavir, adefovir, telbivudine and tenofovir, for the prevention of hepatitis b virus (hbv) reactivation and hbv-related complications in chronic hepatitis b virus (chb) infected patients with hematological malignancies receiving chemotherapy or hematopoietic stem cell transplantation (hsct) by network meta-analysis. | 2017 | 28317397 |
| prevalence of hepatitis b virus between qeshm island people in 2013-2014, iran. | introduction: about 1/ 3 of the world crowd (2 billion) suffers from hbv infection. 15 to 40% of hepatitis b cases develop into chronic hepatitis, cirrhosis, and hepatocellular carcinoma (hcc). considering the dangerous complication of the illness and the evidence that the prevalence is different in various areas of the country, this research was directed with the purpose of determining the currency of the hepatitis b between qeshm island crowds. method: this cross-partial research was directed ... | 2015 | 28316686 |
| predominance of hepatitis b virus genotype a among treated hiv infected patients experiencing high hbv drug resistance in nairobi, kenya. | hbv/hiv coinfections are becoming common with information on hbv genetic diversity and drug resistance still remaining elusive. to evaluate the hbv genetic diversity and drug resistance associated mutations among drug experienced hiv patients, the genetic analysis of the partial hbv-pol-reverse trancriptase gene was successfully sequenced from 13 samples. analysis of the sequences showed that all (13) the sequences belonged to genotype a. nucleos(t)ide drug resistance mutations were found in six ... | 2017 | 28316253 |
| hepatitis b virus and human t-cell lymphotropic virus type 1 co-infection in the northern territory, australia. | to establish the relationship between hepatitis b virus (hbv) and human t-cell lymphotropic virus type 1 (htlv-1) serological markers in the northern territory, australia. | 2017 | 28315754 |
| stimulation of inducible nitric oxide by hepatitis b virus transactivator protein-hbx requires mta1 coregulator. | 2017 | 28314778 | |
| on-treatment hbv dna level could predict hbeag seroclearance in patients with hbeag-positive chronic hepatitis b with entecavir therapy. | hepatitis b e antigen (hbeag) status is associated with clinical outcomes, and seroconversion of hbeag is one of the treatment goals. in this study, we determined the association of on-treatment serum hepatitis b virus (hbv) dna levels in hbeag-positive chronic hepatitis b patients who were receiving entecavir (etv) treatment. | 2017 | 28314596 |
| diagnosis of viral hepatitis. | chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infections and hiv-hbv and hcv coinfection are major causes of chronic liver disease worldwide. testing and diagnosis is the gateway for access to both treatment and prevention services, but there remains a large burden of undiagnosed infection globally. we review the global epidemiology, key challenges in the current hepatitis testing response, new tools to support the hepatitis global response (2016-2020 global hepatitis health sector ... | 2017 | 28306597 |
| therapeutic plasma exchange versus double plasma molecular absorption system in hepatitis b virus-infected acute-on-chronic liver failure treated by entercavir: a prospective study. | therapeutic plasma exchange (tpe) and double plasma molecular absorption system (dpmas) were two extracorporeal liver support systems. few studies compared their efficacy profile. | 2017 | 28304106 |
| silent killers: transfusion transmissible infections-tti, among asymptomatic population of pakistan. | to analyse transfusion transmissible infections in asymptomatic population. | 2017 | 28303984 |
| sb 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant hcv variants. | sb 9200 is a novel, first-in-class oral modulator of innate immunity that is believed to act via the activation of the rig-i and nod2 pathways. sb 9200 has broad-spectrum antiviral activity against rna viruses including hepatitis c virus (hcv), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis b virus (hbv) in vitro and in vivo. in phase i clinical trials in chronically infected hcv patients, sb 9200 has been shown to reduce hcv rna by up to 1.9 ... | 2017 | 28303593 |
| seroepidemiology of hepatitis a, hepatitis b and varicella virus in people living with hiv in ireland. | epidemiological studies investigating seroprevalence of vaccine preventable infections at both individual and population level are important in guiding screening and vaccination practices. data on seroprevalence of common vaccine preventable infections in hiv-infected individuals is lacking. we carried out a retrospective cohort study to investigate serological immunity and factors associated with immunity to hepatitis a virus (hav), hepatitis b virus (hbv) and varicalla virus (vzv) in a cohort ... | 2017 | 28302512 |
| active immunization against transforming growth factor-beta1 prevents hepatic fibrosis in a rat model of liver disease. | transforming growth factor-beta1 (tgf-β1) plays an important role in hepatic fibrogenesis. to document the effects of active immunization against tgf-β1 on hepatic fibrosis in an animal model of chronic liver disease. balb/c mice were immunized against three different peptides of tgf-β1 ligated into hepatitis b virus core protein (hbvc). titers of tgf-β1 antibodies were documented by enzyme linked immunoassays and antibody activity by cell membrane receptor binding and proliferation assays. the ... | 2017 | 28301738 |
| association between the telomerase rs2736098_tt genotype and a lower risk of chronic hepatitis b and cirrhosis in chinese males. | chronic hepatitis b (chb) is caused by infection of hepatitis b virus (hbv) and liver cirrhosis (lc) is its most common complication. the accumulated evidence indicates a genetic context of hbv infection phenotypes. here we determine a potential association of chb/lc with the genetic variant of telomerase reverse transcriptase (tert), a key player in aging including immune-senescence. | 2017 | 28300824 |
| the enrichment of hbv immune-escape mutations during nucleoside/nucleotide analogue therapy. | drug-resistant hbv mutants frequently arise during nucleos(t)ide analogues (nas) therapy, while the resistance mutations on polymerase also have consequent changes in the s protein. besides, the enrichment of immune-escape mutations was negatively correlated with hbsag clearance under nas therapy. this study aims to characterize the variability of hepatitis b virus polymerase and surface antigen in patients with virologic breakthrough under nucleos(t)ide analogues therapy. | 2017 | 28300730 |
| sero-prevalence of hepatitis b surface antigen amongst pregnant women attending an antenatal clinic, volta region, ghana. | hepatitis b virus (hbv) infection remains a global challenge, although there is currently a safe and effective vaccine available. hbv prevalence in ghana is not well documented, but vary regionally from 4.8% to 12.3% in the general population, 10.8% to 12.7% in blood donors and about 10.6% in pregnant women. this puts ghana among the high endemic countries in africa. the study objective was to determine the sero-prevalence of hbs antigen (ag) and hbeag among pregnant women in the ho municipality ... | 2016 | 28299162 |
| low coverage of hepatitis b vaccine and determinants among health professionals working in amhara regional state hospitals, ethiopia. | more than two billion people have been infected with hepatitis b virus (hbv), 360 million have chronic infection and 600,000 die each year from hbv-related liver disease or hepatocellular carcinoma. each year more than 66,000 health professionals are infected by hepatitis b virus and vaccination against hepatitis b saves the life's of these health professionals. the aim of this study was to determine the prevalence and associated factors of hepatitis b vaccine coverage in a resource limited sett ... | 2016 | 28299157 |
| [the potential use of serum hbv rna to guide the functional cure of chronic hepatitis b]. | hepatitis b virus (hbv) covalently closed circular dna (cccdna) in infected hepatocytes is the main cause of off-therapy viral rebound. the half-life of cccdna is only 33-50 days, so the conversion of newly synthesized rcdna to cccdna in the nucleus is essential for the maintenance of cccdna pool in infected hepatocytes. though not directly targeting the existing cccdna, current nucleos(t)ide analogues (nas) may exhaust the cccdna reservoir by blocking the rcdna formation. indeed, a prolonged co ... | 2017 | 28297795 |
| [research advances in diagnosis and treatment of liver failure in 2016]. | liver failure has various clinical types, a complex pathogenesis, and rapid disease progression, as well as a high mortality rate. liver failure caused by hepatitis b virus infection is the most common type in china with severe conditions, various complications, and a mortality rate as high as 40%-90%. invasive fungal disease secondary to acute-on-chronic liver failure can affect patients' prognosis and increase mortality rate. this article introduces the research advances in hepatitis b-related ... | 2017 | 28297793 |
| [advances in clinical research on rta181 mutation in hepatitis b virus]. | nowadays, nucleos(t)ide analogues (nas) are important drugs for the treatment of chronic hepatitis b and can suppress the virus through inhibiting the activity of hepatitis b virus (hbv) polymerase. however, rta181 mutation in hbv can reduce the sensitivity of hbv to various nas, which brings new challenges to antiviral therapy. this article briefly introduces the research advances in the clinical detection rate of rta181 mutation and its influence on therapeutic effect and prognosis. | 2017 | 28297788 |
| [risk factors for hospital-acquired infection in patients with liver cirrhosis and value of immuknow assay in monitoring immune cell function]. | 2017 | 28297778 | |
| genetic variation in the vitamin d pathway cyp2r1 gene predicts sustained hbeag seroconversion in chronic hepatitis b patients treated with pegylated interferon: a multicenter study. | evidence of a role of vitamin d in the immune system is increasing. low serum vitamin d is associated with increased hepatitis b virus replication. genome-wide association study (gwas) data has revealed a number of the single nucleotide polymorphisms (snps) within the vitamin d synthetic pathway that affect vitamin d functions. we aimed to determine the association between snps in the vitamin d gene cascade and response to pegylated interferon (pegifn) therapy in hepatitis b e-antigen (hbeag)-po ... | 2017 | 28296915 |
| ugt1a1*28 relationship with abnormal total bilirubin levels in chronic hepatitis c patients: outcomes from a case-control study. | gilbert syndrome (gs) is a frequent benign clinical condition, marked by intermittent unconjugated hyperbilirubinemia, mostly due to the polymorphism uridine diphosphate-glucuronosyltransferase 1a1*28 (ugt1a1*28). hyperbilirubinemia has been reported in a gs patient undergoing hepatitis c treatment, and other ugt isoforms polymorphisms have been linked to worse outcomes in viral hepatitis. yet, little is known to gs contributions' to the liver disease scenario. our aim was to assess ugt1a1 genot ... | 2017 | 28296739 |
| severity and outcome of acute-on-chronic liver failure is dependent on the etiology of acute hepatic insults: analysis of 368 patients. | acute-on-chronic liver failure (aclf) may be precipitated by various hepatic insults. the present study evaluated the outcomes of aclf with different acute insults. | 2017 | 28296656 |
| the full length genomic sequence of a novel hla-a*24 allele, hla-a*24:353, identified in a patient with hepatitis b infection. | hla-a*24:353 differs from hla-a*24:02:01 by an amino acid exchange glutamine to glutamate at position 316. | 2017 | 28296275 |
| long term outcome of inactive and active, low viremic hbeag negative hepatitis b virus infection: benign course towards hbsag clearance. | the difference between the long-term outcome of low-viremic (hbv-dna≤20,000-iu/ml, lv-ac) and inactive hbsag carriers (hbv-dna≤2,000-iu/ml, ic) remains to be defined. we studied prospectively 153 hbeag-negative hbsag-carriers with baseline hbv-dna≤20,000-iu/ml and normal transaminases. | 2017 | 28296013 |
| low hepatitis b virus-specific t-cell response in males correlates with high regulatory t-cell numbers in murine models. | hepatitis b virus (hbv) infection shows significant gender-related differences in pathogenesis, disease progression, and development of hepatocellular carcinoma. the gender-associated differences in hbv replication and viral protein levels may be associated with distinct hbv-specific immune responses in the host. in the present study, we examined the impact of gender on hbv-specific immune responses in two different mouse models representing transient and persistent hepadnaviral infection; hydro ... | 2017 | 28295453 |
| elimination of hepatitis b: is it a mission possible? | chronic hepatitis b virus (hbv) infection is a global public health issue. although the disease cannot be cured effectively, disease management has been improved over the past decade. the introduction of potent nucleos(t)ide analogues (nas) to suppress viral replication represented a giant leap in the control of this disease. it has been shown that tenofovir treatment, a potent na, complements current immunoprophylaxis to diminish mother-to-infant transmission in pregnant women with a high viral ... | 2017 | 28292309 |
| a preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis c virus infection in hunan, china. | european researchers have underscored associations between single nucleotide polymorphism (snp) rs2287622 of the hepatobiliary bile salt export pump (bsep) gene and the risk of hepatitis c virus (hcv) infection. the distributions of snp rs2287622 are racially specific. this study was aimed to preliminarily investigate the distribution of bsep gene snp rs2287622 in the han patients with chronic hcv-infection (chc) in hunan, china. | 2017 | 28292275 |
| [seroprevalence of viral markers among blood donors at the blood donor center of mohammed v military teaching hospital of rabat, morocco]. | this study aims to determine the prevalence of human immunodeficiency virus (hiv) infections and hepatitis b virus (hbv) and hepatitis c virus (hcv) infections among blood donors at the blood donor center, mohammed v military teaching hospital between 2010 and 2012. we conducted a retrospective study among military blood donors aged 18-50 years, with a male predominance (95%). pre-donation interview is the first selection barrier for individuals at risk. biological screening was performed by liq ... | 2016 | 28292147 |
| high association of t1858-g1896 precore mutations with impaired base pairing and high hepatitis b virus dna levels in hbeag-negative chronically infected patients. | the progression of liver disease in hepatitis b virus (hbv) infection is fostered by active virus replication. mutations in the basal core promoter (bcp) and precore (pc) regions of the hbv genome are known to have an impact on viral replication. the aim of the present study was to assess the correlation of mutation profiles in the bcp and pc regions with the viral load in hbeag-negative chronically infected patients. the hbv genotype, bcp/pc mutations, serum hbv dna levels, and associated serol ... | 2017 | 28289975 |
| fibrosing cholestatic hepatitis following renal transplantation in a patient infected with the hepatitis b virus. | 2006 | 28286446 | |
| detection of hbv dna and antigens in hbsag-positive patients with primary hepatocellular carcinoma. | hepatitis b virus (hbv) markers include hbv deoxyribonucleic acid (dna) and hbv antigens. the former involves hbv covalently closed circular dna (cccdna) as well as total hbv dna, whereas the latter involves hbsag, hbcag, and hbx. | 2017 | 28286056 |
| hepatitis b vaccination status in an at-risk adult population: long-term immunity but insufficient coverage. | in france, hepatitis b (hb) vaccine has been offered to all infants since 1994, and was proposed to all children aged 11 years from 1994 to 1998. nevertheless, hb vaccine hesitancy may result in low vaccination coverage in present-day at-risk adults. we aimed to determine hb vaccination coverage in adults attending a free testing center for sexually transmitted infections (sti). as part of routine care, three classes of data were anonymously collected from attendees over a 3-month period: result ... | 2017 | 28285330 |
| no. 342-hepatitis b and pregnancy. | to review the epidemiology, natural history, evaluation, and treatment of hepatitis b virus (hbv) infection during pregnancy. this will aid obstetric care providers in counseling their patients regarding perinatal risks and management options available to pregnant women with hepatitis b. | 2017 | 28284515 |
| a highly sensitive electrochemical immunosensor for hepatitis b virus surface antigen detection based on hemin/g-quadruplex horseradish peroxidase-mimicking dnazyme-signal amplification. | here we prepared an electrochemical immunosensor employing au sheet as working electrode, fe3o4 magnetic nanoparticles (mnps) as supporting matrix and hemin/g-quadruplex dnazyme as signal amplifier for determination of hepatitis b virus surface antigen (hbsag). first, the primary antibody of hbs (ab1) was immobilized on the surface of the carboxyl-modified mnps. then, the assembly of antibody and alkylthiol/g-quadruplex dna/hemin on gold nanoparticles was used as bio-bar-coded nanoparticle probe ... | 2017 | 28284078 |
| combination therapy with lamivudine and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker for hepatitis b virus-associated glomerulonephritis with mild to moderate proteinuria: a clinical review of 38 cases. | the treatment of hbv-associated glomerulonephritis (hbv-gn) is still a challenge in clinical practice now. the objective of this study was to report the pathological characteristics of hbv-gn presenting with mild to moderate proteinuria and to evaluate the therapeutic efficacy of lamivudine (lam) in combination with angiotensin-converting enzyme inhibitor (acei)/angiotensin receptor blocker (arb) as compared to acei/arb monotherapy. | 2017 | 28283858 |
| serum hepatitis b core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular dna in chronic hepatitis b. | recently, hepatitis b core-related antigen (hbcrag) has been suggested as an additional marker of hepatitis b virus (hbv) infection. this study aimed to investigate whether serum quantitative hbcrag (qhbcrag) was a satisfactory surrogate marker of intrahepatic covalently closed circular dna (cccdna). a total of 139 patients with liver biopsy were enrolled, consisting of 59 patients in immune tolerance (it) phase, 52 patients in immune clearance (ic) phase, 18 patients in low-replication (lr) pha ... | 2017 | 28282964 |
| hepatitis b virus x protein stimulates proliferation, wound closure and inhibits apoptosis of huh-7 cells via cdc42. | chronic hepatitis b virus (hbv) infection has been considered as the major cause of hepatocellular carcinoma (hcc). hepatitis b virus x protein (hbx) has been reported to be oncogenic. the underlying mechanisms of hbv-related hcc are not fully understood, and the role played by the hbx protein in hbv induced carcinogenesis remains controversial. cdc42, a member of the rho gtpase family, has been reported to be overexpressed in several different cancers, including hbv-related hcc. however, the sp ... | 2017 | 28282856 |
| interleukin-23 mediates the pathogenesis of lps/galn-induced liver injury in mice. | interleukin-23 (il-23) is required for t helper 17 (th17) cell responses and il-17 production in hepatitis b virus infection. a previous study showed that the il-23/il-17 axis aggravates immune injury in patients with chronic hepatitis b virus infection. however, the role of il-23 in acute liver injury remains unclear. | 2017 | 28282579 |
| a novel colorimetric pcr-based biosensor for detection and quantification of hepatitis b virus. | hepatitis b virus (hbv) can cause viral infection that attacks the liver and it is a major global health problem that puts people at a high risk of death from cirrhosis of the liver and liver cancer. hbv has infected one-third of the worldwide population, and 350 million people suffer from chronic hbv infection. for these reasons, development of an accurate, sensitive, and expedient detection method for diagnosing, monitoring, and assessing therapeutic response of hbv is very necessary and urgen ... | 2017 | 28281267 |
| interrelationship of hepatitis c virus genotypes with patient characteristics in bahrain. | hepatitis c virus (hcv) shows genotype-based variation in prevalence across geographical regions. this study was conducted to understand the clinical interrelationship of hcv genotypes with patient characteristics. | 2017 | 28280398 |
| comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis b patients. | there have been limited studies directly comparing the long-term efficacy between entecavir (etv) and tenofovir disoproxil fumarate (tdf). this study was aimed to compare the long-term efficacy between them in treatment-naïve chronic hepatitis b (chb). | 2017 | 28279168 |
| polymorphisms in the il-17 gene (rs2275913 and rs763780) are associated with hepatitis b virus infection in the han chinese population. | interleukin-17 (il-17) can accelerate the release of many pro-inflammatory cytokines. the purpose of our study was to investigate the potential association between polymorphisms in the il-17 gene and susceptibility to hepatitis b virus (hbv) infection in the han chinese population. | 2017 | 28277785 |
| towards elimination of hepatitis b and c in european union and european economic area countries: monitoring the world health organization's global health sector strategy core indicators and scaling up key interventions. | the world health organization 'global health sector strategy on viral hepatitis 2016-2021' aimed at the elimination of viral hepatitis as a public health threat provides a significant opportunity to increase efforts for tackling the epidemics of hepatitis b and hepatitis c virus infections across europe. to support the implementation and monitoring of this strategy, core epidemiological and programmatic indicators have been proposed necessitating specific surveys, the systematic collection of pr ... | 2017 | 28277217 |
| long-term persistence of immunity after hepatitis b vaccination: is this substantiated by the literature? | hepatitis b vaccination is held to provide life-long protection against hepatitis b virus (hbv) infection, but evidence for this notion remains wanting, since no studies have assessed the vaccinees in their fourth decade of life. indeed, there are several reports indicating that despite vaccination in infancy, the prevalence of hbv infection still increased with age in the vaccinees, and that both anti-hbs titer and anamnestic response declined with age. clearly it is time to clarify the long-te ... | 2017 | 28277087 |
| effect of hla-dpa1 alleles on chronic hepatitis b prognosis and treatment response. | chronic hepatitis b (chb) is a major health problem. the outcome of hepatitis b virus (hbv) infection is associated with variations in hla-dpa1 alleles. the aim of this study was to investigate possible associations of hla-dpa1 alleles with treatment response and with hepatitis b virus e antigen (hbeag) seroconversion. | 2016 | 28275747 |
| transmission of hbv dna mediated by ceramide-triggered extracellular vesicles. | an extracellular vesicle (ev) is a nanovesicle that shuttles proteins, nucleic acids, and lipids, thereby influencing cell behavior. a recent crop of reports have shown that evs are involved in infectious biology, influencing host immunity and playing a role in the viral life cycle. in the present work, we investigated the ev-mediated transmission of hepatitis b virus (hbv) infection. | 2017 | 28275693 |
| advancing the regulatory path on hepatitis b virus treatment and curative research: a stakeholders consultation. | hepatitis b infection remains a significant disease burden around the world, with an estimated two billion individuals infected and 350 million living with chronic hepatitis b. current antivirals are efficacious, but require lifelong treatment for the majority of infected individuals. the field is galvanised to improve diagnostics and treatment with the goal to develop shorter, finite treatments leading to viral control after treatment discontinuation. achievement of complete and functional cure ... | 2017 | 28275452 |
| [exogenous hbx promotes epithelial-mesenchymal transition of hepatic progenitor cells in kunming mice]. | objective to construct an animal model in which hepatitis b virus x protein (hbx) directly affect hepatic progenitor cells (hpcs), and investigate the potential mechanisms underlying epithelial-mesenchymal transition (emt) of hpcs. methods kunming mice were given 2 ml/l carbon tetrachloride (ccl4) in oil solution by gavage twice a week. four weeks later, hpcs transfected with recombinant lentiviral vectors stably expressing hbx gene as well as empty vectors were separately injected into the mice ... | 2017 | 28274311 |
| [recombinant hbcag promotes secretion of il-15 in myeloid dendritic cells via p38mapk signaling pathway]. | objective to study the mechanism by which recombinant human hepatitis b virus core antigen (rhhbcag) induces interleukin-15 (il-15) secretion in myeloid dendritic cells (mdcs). methods human peripheral blood monocytes were isolated from peripheral blood of healthy volunteers by dynabeads untouched human monocytes kit. we obtained mdcs by culturing the monocytes in the presence of gm-csf, il-4 and tnf-α. in one group, mdcs were cultured in rpmi1640 and stimulated by rhhbcag at the final concentra ... | 2017 | 28274303 |
| effect of 48-week pegylated interferon α-2a or nucleos(t)ide analogue therapy on renal function in chinese patients with chronic hepatitis b. | controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis b virus (hbv) infection. thus, the aim of study was to analyze the changes in renal function of chronic hepatitis b (chb) patients in response to anti-hbv therapy and the association with treatments. | 2017 | 28274240 |
| nkg2d modulates aggravation of liver inflammation by activating nk cells in hbv infection. | hepatitis b virus (hbv) infection is thought to be an immune-mediated liver disease. the mechanisms underlying natural killer (nk) cell group 2d receptor (nkg2d) that activates nk cells and participates in anti-hbv immunity and immunopathology has not been thoroughly elucidated. peripheral nkg2d(+) and ifn-γ(+) nk cells frequencies and intrahepatic nkg2d and ifn-γ mrna and protein expressions were determined in hbv-infected patients. levels of nkg2d and ifn-γ mrna and protein in nk cells, co-cul ... | 2017 | 28273905 |
| long term trends in chronic hepatitis b virus infection associated liver transplantation outcomes in the united states. | with effective antiviral therapies, rates of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) and decompensated liver disease requiring liver transplantation (lt) are expected to decrease. we aim to evaluate overall trends in lt waitlist registrations, waitlist survival, and likelihood of receiving lt among chronic hbv patients in the u.s. using the united network for organ sharing database, we retrospectively evaluated adults (age >18) with chronic hbv (with and without hcc) liste ... | 2017 | 28273387 |
| influence of treg cells and hbv genotype on sustained response and drug resistance in the treatment with nucleoside drugs. | we aimed to investigate the influence of regulatory t cells including cd4+cd25+, cd8+cd28- and hepatitis b virus (hbv) genotype on sustained virological response and tolerance of nucleoside drugs. one hundred and thirty-seven patients were enrolled. lamivudine was administered to 84 patients. entecavir was administered to the other 53 patients. before treatment, biochemical tests, hbv dna load, hbv serum level, hbv genotype, pb cd3+, cd4+, cd8+, cd4+cd25+/cd3+, and cd8+cd28-/cd3+ frequencies wer ... | 2017 | 28273209 |
| expression of microrna-122 and microrna-22 in hbv-related liver cancer and the correlation with clinical features. | micrornas (mir) participate in cell proliferation, apoptosis and transformation, as they can regulate gene expression and intracellular signal transduction for various physiological processes. mir-122 and mir-22 are known to be related with occurrence and progression of hepatitis b virus (hbv)-related hepatocellular cancer (hcc). this study recruited hbv-related hcc patients, whose expression levels of mir-122 and mir-22 were determined to analyze the correlation with clinical and pathological i ... | 2017 | 28272709 |
| nucleic acid-based polymers effective against hepatitis b virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells. | nucleic acid polymers (naps) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis b virus (hbv) in patients. analysis of immunostimulatory properties of naps were conducted with several nap species: rep 2006, the prototypic degenerate nap [dn]40, containing tlr9-stimulatory cpg; rep 2055 a clinically active nap with a sequence [dadc]20 devoid of cpg content; rep 2139 (also clinically active) and rep 2165 (rep 2055 analog ... | 2017 | 28272460 |
| knowledge, attitude and behaviours towards recommended vaccinations among healthcare workers. | healthcare workers (hcws) are an important group of professionals exposed to biological risk during their work activities. so, the aim of this study is to perform a survey on the knowledge, attitude and behaviour of italian hcws towards the vaccinations recommended by the ministry of health. a cross-sectional study was carried out during the period september 2014-august 2015 in the lazio region. the study was conducted by recruiting hcws and biomedical students. the sample was comprised of 571 r ... | 2017 | 28272332 |
| a new oleanolic acid derivative against ccl₄-induced hepatic fibrosis in rats. | a novel hepatoprotective oleanolic acid derivative, 3-oxours-oleana-9(11), 12-dien-28-oic acid (oxy-di-oa), has been reported. in previous studies, we found that oxy-di-oa presented the anti-hbv (hepatitis b virus) activity (ic50 = 3.13 µg/ml). remarkably, it is superior to lamivudine in the inhibition of the rebound of the viral replication rate. furthermore, oxy-di-oa showed good performance of anti-hbv activity in vivo. some studies showed that liver fibrosis may affiliate with hbv gene mutat ... | 2017 | 28272302 |
| predictive value of serum alt and t-cell receptor beta variable chain for hbeag seroconversion in chronic hepatitis b patients during tenofovir treatment. | effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis b (chb). identification of serum indices, including hepatitis b e antigen (hbeag) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in hbeag-positive chb patients. the biochemical, serological, virological parameters, and the frequency of circulating cd4cd25 regulatory t cell (treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of ... | 2017 | 28272219 |
| the expression of b7-h3 in circulating cd4+cd25high t cells, circulating cd14+ monocytes and plasma during hepatitis b virus infection progression. | b7-h3 is frequently upregulated in response to autoantigens and pathogens during host t cell immune responses. however, the role of b7-h3 which express in cd14+ monocytes and cd4+cd25high t cells had not been investigated. | 2017 | 28271685 |
| antiviral therapy in chronic hepatitis b with mild acute exacerbation. | the aim of this study was to assess the efficacy and safety of peginterferon α-2a (pegifn) and nucleos(t)ide analogues (na) treatments in patients with hepatitis b envelope antigen (hbeag)-positive chronic hepatitis b (chb) with mild acute exacerbation (ae). | 2017 | 28270871 |
| characterization of occult hepatitis b virus infection among hiv positive patients in cameroon. | occult hepatitis b infection (obi) among hiv positive patients varies widely in different geographic regions. we undertook a study to determine the prevalence of occult hepatitis b infection among hiv infected individuals visiting a health facility in south west cameroon and characterized occult hbv strains based on sequence analyses. | 2017 | 28270215 |
| role of hla-dp and hla-dq on the clearance of hepatitis b virus and the risk of chronic infection in a multiethnic population. | hbv infection exhibits geographical variation in its distribution in south america. while hbv rates are low in central argentina, the north-western region exhibits intermediate hbv rates. unfortunately, the reasons that could explain this difference are still unknown. | 2017 | 28267888 |
| microrna-125b-5p mediates post-transcriptional regulation of hepatitis b virus replication via the lin28b/let-7 axis. | micrornas (mirnas) are able to modulate hepatitis b virus (hbv) replication and play an important role in the pathogenesis of hbv infection. recently, we have identified that serum mir-125b-5p levels correlated with hbv dna levels and liver necroinflammation. in the present study, we addressed how mir-125b-5p regulated hbv replication at the different steps, inclduing viral transcription, assembly, and virion production and investigated the underlying mechanisms. we found that mir-125b-5p overex ... | 2017 | 28267418 |
| hepatitis b virus vaccination in hiv-infected people: a review. | hbv immunization is highly recommended in people infected with hiv. however, the classical schedule used in the general population has been shown to be insufficient in people living with hiv. this review summarizes the main studies dealing with hbv vaccination in people living with hiv, depending on their baseline status (in particular, never vaccinated, already vaccinated, or with an isolated anti-hbc serological profile). it shows that reinforced 40µg intramuscular hbv vaccination schedules ar ... | 2017 | 28267387 |
| reply to letter: "adjuvant antiviral therapy with nucleos(t)ide analogs in patients with hepatitis b virus--related hepatocellular carcinoma". | 2017 | 28266989 | |
| postoperative antiviral therapy with nucleos(t)ide analogs in patients with hepatitis b virus--related hepatocellular carcinoma. | 2017 | 28266988 | |
| prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-dna complexes. | approximately 250 million people worldwide are chronically infected with hepatitis b virus (hbv) and more than half of the hepatocellular carcinoma (hcc) cases are attributed to this infection. as hcc has a high mortality rate, and current treatment options are remarkably limited, the development of new therapeutic treatment strategies is warranted. | 2017 | 28264666 |
| cure strategies for hepatitis b virus: the promise of immunotherapy. | chronic hepatitits b virus remains a public health challenge, infecting more than 240 million people globally and causing 600,000 deaths per year from end-stage liver disease and/or hepatocellular carcinoma. current antiviral therapeutic agents are highly effective at blocking viral replication, but discontinuation of therapy prior to loss of hepatitis b surface antigen generally leads to relapse. new modalities that target host factors of viral persistence such as immune response pathway inhibi ... | 2017 | 28263466 |
| characterization of gene expression profiles in hbv-related liver fibrosis patients and identification of itgbl1 as a key regulator of fibrogenesis. | although hepatitis b virus (hbv) infection is the leading cause of liver fibrosis (lf), the mechanisms underlying liver fibrotic progression remain unclear. here, we investigated the gene expression profiles of hbv-related lf patients. whole genome expression arrays were used to detect gene expression in liver biopsy samples from chronically hbv infected patients. through integrative data analysis, we identified several pathways and key genes involved in the initiation and exacerbation of liver ... | 2017 | 28262670 |
| adverse effects of oral antiviral therapy in chronic hepatitis b. | oral nucleoside/nucleotide analogues (nas) are currently the backbone of chronic hepatitis b (chb) infection treatment. they are generally well-tolerated by patients and safe to use. to date, a significant number of patients have been treated with nas. safety data has accumulated over the years. the aim of this article is to review and update the adverse effects of oral nas. nas can cause class adverse effects (i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. all nas ... | 2017 | 28261380 |
| preoperative lymphocyte-to-monocyte ratio predicts survival in primary hepatitis b virus-positive hepatocellular carcinoma after curative resection. | both inflammation and immunity are associated with the development of malignancy. the lymphocyte-to-monocyte ratio (lmr) has been confirmed as a prognostic factor for several malignant diseases. the purpose of our study was to analyze prognostic significance of preoperative lmr in hepatitis b virus (hbv)-related hepatocellular carcinoma after curative resection. | 2017 | 28260933 |
| higher serum interleukin-17a levels as a potential biomarker for predicting early disease progression in patients with hepatitis b virus-associated advanced hepatocellular carcinoma treated with sorafenib. | although sorafenib is the only available drug with proven efficacy for patients with advanced hepatocellular carcinoma (hcc), the clinical efficacy of sorafenib is variable and unpredictable. the aim of the current study was to identify potential serum biomarkers predicting cancer progression and overall survival (os) in patients with hepatitis b virus (hbv)-related advanced hcc treated with sorafenib. | 2017 | 28260649 |
| differential regulation of hepatitis b virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region. | hepatitis b virus (hbv) transcribes two subsets of 3.5-kb rnas: precore rna for hepatitis b e antigen (hbeag) expression, and pregenomic rna for core and p protein translation as well as genome replication. hbeag expression could be prevented by mutations in the precore region, while an upstream open reading frame (uorf) has been proposed as a negative regulator of core protein translation. we employed replication competent hbv dna constructs and transient transfection experiments in huh7 cells ... | 2017 | 28260621 |
| a danish nationwide questionnaire study of hepatitis b virus screening before immunosuppressive therapy. | difficulty in identifying patients who are at risk for hepatitis b virus (hbv) reactivation makes it import-ant to screen for hbv before initiating immunosuppressive therapy. the aim of this study was to investigate screening procedures for hbv infection before initiation of immunosuppressive therapy and to explore hbv treatment strategies. | 2017 | 28260595 |
| living kidney donor cancellation at king hussein medical center. | living-related kidney donation is the main source of renal grafts in jordan, since kidneys from deceased donors are scarce. although the jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. we review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. | 2017 | 28260449 |
| low utility of fluorodeoxyglucose-positron emission tomography/computed tomography for detecting hepatocellular carcinoma in patients before liver transplantation. | our program routinely used fluorodeoxyglucose-positron emission tomography/computed tomography as part of the liver transplant evaluation of patients with hepatocellular carcinoma. the aim of this study was to evaluate the role of this imaging modality in the pretransplant work-up. | 2017 | 28260429 |
| th17/treg imbalance and increased interleukin-21 are associated with liver injury in patients with chronic severe hepatitis b. | th17/treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. the aim of the current study was to assess the treg/th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepatitis b virus (hbv) infection. | 2017 | 28259000 |
| yield optimisation of hepatitis b virus core particles in e. coli expression system for drug delivery applications. | an e. coli expression system offers a mean for rapid, high yield and economical production of hepatitis b virus core (hbc) particles. however, high-level production of hbc particles in bacteria is demanding and optimisation of hbc particle yield from e. coli is required to improve laboratory-scale productivity for further drug delivery applications. production steps involve bacterial culture, protein isolation, denaturation, purification and finally protein assembly. in this study, we describe a ... | 2017 | 28256592 |
| [antiviral therapy in the third trimester to prevent mother-to-infant transmission of hepatitis b virus:benefit or harm?] | 2017 | 28253569 | |
| variation in the viral hepatitis and hiv policies and practices of methadone maintenance programs. | patients prescribed methadone maintenance treatment (mmt) demonstrate elevated prevalence of hepatitis b virus (hbv), hepatitis c virus, and hiv. government agencies recommend testing for these infections in mmt programs, but uptake is limited. | 2017 | 28252455 |
| enhanced fluorescence elisa based on hat triggering fluorescence "turn-on" with enzyme-antibody dual labeled aunp probes for ultrasensitive detection of afp and hbsag. | at present, enzyme-linked immunosorbent assay (elisa) is considered to be the most appropriate approach in clinical biomarker detection, with good specificity, low cost, and straightforward readout. however, unsatisfactory sensitivity severely hampers its wide application in clinical diagnosis. herein, we designed a new kind of enhanced fluorescence enzyme-linked immunosorbent assay (felisa) based on the human alpha-thrombin (hat) triggering fluorescence "turn-on" signals. in this system, detect ... | 2017 | 28252291 |
| fibrosis assessment in patients with chronic hepatitis b virus (hbv) infection. | chronic hepatitis b virus (hbv) infection is a major cause of liver morbidity and mortality worldwide. while a proportion of the 250 million individuals chronically infected with hbv will not come to significant harm or require therapy, many others risk developing complications of the end-stage liver disease such as decompensated cirrhosis and hepatocellular carcinoma (hcc), without intervention. due to the complex natural history of hbv infection, patients require an expert assessment to interp ... | 2017 | 28251119 |
| optimizing antiviral agents for hepatitis b management in malignant lymphomas. | the global scale of hepatitis b infection is well known but its impact is still being understood. missed hepatitis b infection impacts lymphoma therapy especially increased risk of hepatitis b virus (hbv) reactivation and poor treatment outcomes. the presence of undiagnosed chronic hepatitis also undermines chronic hbv screening methods that are based on a positive hbsag alone. the goal of this review is to evaluate the literature for optimizing antiviral therapy for lymphoma patients with hbv i ... | 2017 | 28251118 |
| pediatric hepatitis b treatment. | although the introduction of hepatitis b vaccine has been contributing to the reduction in the prevalence of hepatitis b virus (hbv) carriers worldwide, the treatment of children with chronic hbv infection is a challenge to be addressed. hbeag seroconversion, which induces low replication of hbv, is widely accepted as the first goal of antiviral treatment in children with chronic hepatitis b. however, spontaneous hbeag seroconversion is highly expected in children with chronic hbv infection. the ... | 2017 | 28251116 |
| quantitative nucleic acid amplification methods and their implications in clinical virology. | recently, a number of techniques have been approved for quantification of viral nucleic acids in clinical samples. viral load (vl) tests have considerable importance in the management of patients and are widely used in routine diagnosis. in clinical virology, vl testing are important to monitor the antiviral treatment, to initiate preemptive therapy, to understand pathogenesis, and to evaluate the infectivity. these tests have now become a part of many diagnostic and treatment guidelines. consid ... | 2017 | 28251100 |
| potential of cannabidiol for the treatment of viral hepatitis. | viral hepatitis b (hbv) and hepatitis c (hcv) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer. while hbv has a vaccine, hcv has none at the moment. the risk of drug resistance, combined with the high cost of current therapies, makes it a necessity for cost-effective therapeutics to be discovered and developed. the recent surge in interest in medical cannabis has led to interest in evaluating and validating th ... | 2017 | 28250664 |
| serum lipid profile as a marker of liver impairment in hepatitis b cirrhosis patients. | chronic hbv infection is a major cause of cirrhosis and an important risk factor to develop hepatocellular carcinoma. the study is conducted to find out the changes in the lipid metabolism of hbv-cirrhosis patients. | 2017 | 28249586 |
| reactivation of occult hbv infection in an hiv/hcv co-infected patient successfully treated with sofosbuvir/ledipasvir: a case report and review of the literature. | reactivation of occult or inactive hepatitis b virus (hbv) infection during immunosuppressant treatments is well known and widely described in literature. the same observation has been made in hepatitis c (hcv)-infected patients previously exposed to hbv and treated with interferon-free daa treatments. because of common transmission routes, persons may have been exposed to hcv, hbv and hiv, but few cases have been reported in this scenario to date. frequency of hbv reactivation in hiv/hcv co-inf ... | 2017 | 28249574 |
| evaluation of two vidas (®)prototypes for detecting anti-hev igg. | high performance anti-hepatitis e virus (hev) igg assays are crucial for epidemiology. | 2017 | 28249234 |
| the independent predictors of significant liver histological changes in chronic hepatitis b virus infection patients with persistently high-normal or low-normal alanine transaminase levels. | to determine the independent predictors of significant liver histological changes (slhc) defined as inflammatory grade ≥a2 and/or fibrosis stage ≥f2 using the metavir scoring system in chronic hepatitis b virus (hbv) infection patients with persistently normal alt (pnalt) levels. | 2017 | 28245424 |
| a mathematical model for estimating residual transmission risk of occult hepatitis b virus infection with different blood safety scenarios. | if anti-hepatitis b core antibody testing is not mandated blood donors with occult hepatitis b infection (obi) may transmit hepatitis b virus (hbv) to a recipient in spite of the use of nucleic acid amplification technology (nat) or pathogen inactivation (pi). | 2017 | 28244600 |
| efficacy and safety analysis of rituximab combined with chemotherapy in the treatment of b-cell lymphoma patients complicated with hepatitis b virus infection. | lymphoma combined with hepatitis b infection occupies a relatively higher incidence in china than that of in europe and america. | 2017 | 28244480 |
| identifying microrna panels specifically associated with hepatocellular carcinoma and its different etiologies. | deregulation of micrornas (mirnas) expression has been identified in hepatocellular carcinoma (hcc), but few results are consistent. the objective of this study is to investigate "hcc tumor type specific" and "tumor common" mirna panels. | 2016 | 28243631 |
| correlations of microvascular blood flow of contrast-enhanced ultrasound and hgf/c-met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma. | the study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (ceus) and hepatocyte growth factor (hgf)/c-met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (hcc). one hundred and eighteen patients pathologically diagnosed as primary hcc were selected. all hcc patients underwent ceus examination before operation. hcc tissues and adjacent normal tissue specimens were obtained to detect the ... | 2017 | 28243120 |
| prognostic value of increased expression of raco-1 in patients with hepatitis b-related hepatocellular carcinoma. | ring domain ap-1 coactivator-1 (raco-1) is a coactivator that links c-jun to growth factor signaling and is essential for ap-1 function. this study aimed to investigate the expression and clinical significance of raco-1 protein in hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) in china. a total of 136 tissue samples of hbv-related hcc were detected by immunohistochemistry (including 76 patients in training cohort and 60 patients in validation cohort). correlation between raco-1 e ... | 2017 | 28243109 |
| label-free proteomic analysis of exosomes derived from inducible hepatitis b virus-replicating hepad38 cell line. | hepatitis b virus (hbv) infection is a major health problem worldwide. recent evidence suggests that some viruses can manipulate the infection process by packing specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. however, the impact of hbv replication on the content of exosomes produced by hepatocytes has not been fully delineated. in this work, an hbv-inducible cell line hepad38 was used to directly compare changes in th ... | 2017 | 28242843 |
| interplay between sirt1 and hepatitis b virus x protein in the activation of viral transcription. | hepatitis b virus (hbv) genome is organized into a minichromosome known as covalently closed circular dna (cccdna), which serves as the template for all viral transcripts. sirt1 is an nad(+)-dependent protein deacetylase which activates hbv transcription by promoting the activity of cellular transcription factors and coactivators. how sirt1 and viral transactivator x protein (hbx) might affect each other remains to be clarified. in this study we show synergy and mutual dependence between sirt1 a ... | 2017 | 28242208 |