Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
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| chronic bronchitis with fungal infection presenting with marked elevation of serum carbohydrate antigen 19-9: a case report. | carbohydrate antigen 19-9 (ca19-9) is the most frequently applied serum tumor marker for diagnosis of cancers in the digestive organs. however, some patients with benign diseases can have elevated serum levels of ca19-9 as well. the current study presents a 55-year-old female who was admitted to our hospital for further evaluation of a nodular cavity shadow in the right lower lobe and clarification of the cause of the marked elevation of serum ca19-9 levels. abdominal mri and gastrointestinal en ... | 2014 | 25337284 |
| compositional and immunobiological analyses of extracellular vesicles released by candida albicans. | the release of extracellular vesicles (ev) by fungal organisms is considered an alternative transport mechanism to trans-cell wall passage of macromolecules. previous studies have revealed the presence of ev in culture supernatants from fungal pathogens, such as cryptococcus neoformans, histoplasma capsulatum, paracoccidioides brasiliensis, sporothrix schenckii, malassezia sympodialis and candida albicans. here we investigated the size, composition, kinetics of internalization by bone marrow-der ... | 2015 | 25287304 |
| imported african histoplasmosis in an immunocompetent patient 40 years after staying in a disease-endemic area. | histoplasmosis caused by histoplasma capsulatum var. duboisii is a rare disease outside central and western africa. in europe, all cases are imported. we report a case of an african histoplasmosis with isolated pulmonary involvement in a non-immunocompromised patient that occurred 40 years after his stay in a disease-endemic area. the patient was given itraconazole. (18)f-fluoro-2-deoxy-d-glucose positron emission tomography-computed tomography was used to assess evolution during treatment. the ... | 2014 | 25246691 |
| a complementary tool for management of disseminated histoplasma capsulatum var. capsulatum infections in aids patients. | in south america, disseminated histoplasmosis due to histoplasma capsulatum var. capsulatum (h. capsulatum), is a severe and frequent opportunistic infection in aids patients. in areas outside the usa where specific-histoplasma antigen detection is not available, the diagnosis is difficult. with the galactomannan antigen (gm) detection, a test commonly used for invasive aspergillosis diagnosis, there is a cross-reactivity with h. capsulatum that can be helpful for the diagnosis of histoplasmosis ... | 2014 | 25201327 |
| staging and response of sternal histoplasmosis by 18f-fdg pet/ct. | histoplasmosis, a granulomatous mycosis caused by the fungus histoplasma capsulatum, is known to primarily affect the lungs and the immune system, with involvement of skeletal system as a rare manifestation, in which case the disease usually assumes multifocality. we present a singular case of a young man diagnosed to have an isolated skeletal histoplasmosis involving the body of sternum where 18f-fdg pet/ct played major role in both diagnosis and in response evaluation to antifungal therapy. | 2015 | 25188644 |
| a case of orbital histoplasmosis. | histoplasma capsulatum var capsulatum is a dimorphic fungus endemic to the ohio and mississippi river valleys of the united states. in this case report, a 33-year-old woman who presented with a right orbital mass causing progressive vision loss, diplopia, and facial swelling is described. lateral orbitotomy with lateral orbital wall bone flap was performed for excisional biopsy of the lesion. the 1.5 × 1.8 × 2.3 cm cicatricial mass demonstrated a granulomatous lesion with necrosis and positive s ... | 2017 | 25186215 |
| histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment. | infective endocarditis is an uncommon manifestation of infection with histoplasma capsulatum. the diagnosis is frequently missed, and outcomes historically have been poor. we present 14 cases of histoplasma endocarditis seen in the last decade at medical centers throughout the united states. all patients were men, and 10 of the 14 had an infected prosthetic aortic valve. one patient had an infected left atrial myxoma. symptoms were present a median of 7 weeks before the diagnosis was established ... | 2014 | 25181311 |
| importance of the association of molecular and immunological diagnosis in immunocompetent patient with histoplasma capsulatum and cryptoccocus neoformans infection: a case report. | this case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. immunoblotting analysis reactivity against histoplasma capsulatum and paracoccidioides brasiliensis were observed. nested-pcr in blood employing species-specific primers was positive for h. capsulatum and cryptococcus neoformans. the evaluation of paucisymptomatic patients with positive results for h. capsulatum and c. neoformans could be relevant for the prevention as well as the pos ... | 2014 | 25180029 |
| laryngeal histoplasmosis. | histoplasma capsulatum is an endemic granulomatous fungus disease. involving the larynx of an immunocompetent patient with this is a rare manifestation. a sixty years old farmer who was previously diagnosed and treated as pulmonary tuberculosis was presented as a progressive change of voice and intermittent attack of unproductive cough with no history of stridor and fever for last 7 months. clinical and imaging investigations were suggestive of laryngeal tuberculosis or laryngeal neoplasm. laryn ... | 2014 | 25178612 |
| monoclonal antibodies to heat shock protein 60 induce a protective immune response against experimental paracoccidioides lutzii. | paracoccidioidomycosis (pcm) is an endemic mycosis in latin america. pcm is primarily caused by paracoccidioides brasiliensis and less frequently by the recently described, closely related species paracoccidioides lutzii. current treatment requires protracted administration of systemic antibiotics and relapses may frequently occur despite months of initial therapy. hence, there is a need for innovative approaches to treatment. in the present study we analyzed the impact of two monoclonal antibod ... | 2014 | 25161111 |
| late occurrence of histoplasma duboisii cutaneous and pulmonary infection 18 years after exposure. | we report an imported case of histoplasma capsulatum var. duboisii (h. duboisii) infection in a white french woman revealed by cutaneous lesions of the scalp, 18 years after her last stay in west and central africa. asymptomatic bilateral pulmonary infiltrates were discovered on thoracic computed tomography. skin biopsy allowed the positive diagnosis showing the typical yeasts; culture of biopsy specimens was positive for h. capsulatum. in the absence of criteria of severity, the patient was tre ... | 2014 | 25155354 |
| hiv-associated histoplasmosis early mortality and incidence trends: from neglect to priority. | histoplasmosis is an endemic fungal infection in french guiana. it is the most common aids-defining illness and the leading cause of aids-related deaths. diagnosis is difficult, but in the past 2 decades, it has improved in this french overseas territory which offers an interesting model of amazonian pathogen ecology. the objectives of the present study were to describe the temporal trends of incidence and mortality indicators for hiv-associated histoplasmosis in french guiana. | 2014 | 25144374 |
| isotopic fractionation by a fungal p450 nitric oxide reductase during the production of n2o. | nitrous oxide (n2o) is a potent greenhouse gas with a 100-year global warming potential approximately 300 times that of co2. because microbes account for over 75% of the n2o released in the u.s., understanding the biochemical processes by which n2o is produced is critical to our efforts to mitigate climate change. in the current study, we used gas chromatography-isotope ratio mass spectrometry (gc-irms) to measure the δ(15)n, δ(18)o, δ(15)n(α), and δ(15)n(β) of n2o generated by purified fungal n ... | 2014 | 25121461 |
| type ii cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of il-33. | interleukin (il)-4 subverts protective immunity to multiple intracellular pathogens, including the fungus histoplasma capsulatum. previously, we reported that h. capsulatum-challenged ccr2(-/-) mice manifest elevated pulmonary fungal burden owing to exaggerated il-4. paradoxical to our anticipation in il-33 driving il-4, we discovered that the latter prompted il-33 in mutant mice. in infected ccr2(-/-) animals, amplified il-33 succeeded the heightened il-4 response and inhibition of il-4 signali ... | 2015 | 25118166 |
| the global regulator ffsge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in fusarium fujikuroi. | the plant pathogenic fungus fusarium fujikuroi is the causal agent of bakanae disease on rice due to its ability to produce gibberellins. besides these phytohormones, f. fujikuroi is able to produce several other secondary metabolites (sms). although much progress has been made in the field of secondary metabolism, the transcriptional regulation of sm biosynthesis is complex and still incompletely understood. environmental conditions, global as well as pathway-specific regulators and chromatin r ... | 2015 | 25115968 |
| glycosylation and immunoreactivity of the histoplasma capsulatum cfp4 yeast-phase exoantigen. | the yeast phase of histoplasma capsulatum is the virulent form of this thermally dimorphic fungal pathogen. among the secreted proteome of histoplasma, culture filtrate protein 4 (cfp4) is a heavily glycosylated factor produced abundantly and specifically by histoplasma yeast cells, suggesting its role in pathogenesis. we have generated three monoclonal antibodies as tools for characterization and detection of cfp4 and determined the epitope each recognizes. through site-directed mutagenesis of ... | 2014 | 25114108 |
| nondisseminated histoplasmosis of the trachea. | histoplasma capsulatum can rarely affect the trachea. we report the case of a 68-year-old woman with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough and subjective throat hoarseness and fullness. chest computed tomography demonstrated no tracheal findings. bronchoscopy found mucosal irregularity, nodularity and vesicular regions in the proximal trachea extending seven centimeters distal to the vocal cords. also seen ... | 2016 | 25043266 |
| calcified granulomatous disease: occupational associations and lack of familial aggregation. | the acute host response to histoplasma capsulatum infection varies according to exposure and susceptibility. late sequelae include calcifications in the lung, thoracic lymphatics, and spleen. determinants of calcified granuloma formation are poorly studied and may differ from those affecting acute response. we examined the occupational associations and familial aggregation of radiographic calcified granulomatous disease to characterize the determinants of calcified granuloma formation. | 2014 | 25038755 |
| histoplasmosis presenting as granulomatous hepatitis: case report and review of the literature. | background. histoplasma capsulatum is the most common endemic mycosis in the united states and is a frequent cause of opportunistic infection in immunodeficient hosts. histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. however, extrapulmonary hepati ... | 2014 | 25013413 |
| validation of an enzyme-linked immunosorbent assay that detects histoplasma capsulatum antigenuria in colombian patients with aids for diagnosis and follow-up during therapy. | we validated an antigen capture enzyme-linked immunosorbent assay (elisa) in colombian persons with aids and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. the sensitivity of the histoplasma capsulatum elisa was 86%, and the overall specificity was 94%. the antigen test successfully monitored the response to therapy. | 2014 | 25008902 |
| comparison of phylogenetically distinct histoplasma strains reveals evolutionarily divergent virulence strategies. | infection with the dimorphic fungus histoplasma capsulatum results from the inhalation of contaminated soil. disease outcome is variable and depends on the immune status of the host, number of organisms inhaled, and the h. capsulatum strain. h. capsulatum is divided into seven distinct clades based on phylogenetic analyses, and strains from two separate clades have been identified in north america (denoted as nam strains). we characterized an h. capsulatum isolate (wu24) from the nam 1 lineage i ... | 2014 | 24987093 |
| in vitro antifungal susceptibility profile and correlation of mycelial and yeast forms of molecularly characterized histoplasma capsulatum strains from india. | the antifungal susceptibility profiles of the mycelial and yeast forms of 23 histoplasma capsulatum strains from pulmonary and disseminated histoplasmosis patients in india are reported here. the mic data of this dimorphic fungus had good agreement between both forms for azoles, amphotericin b, and caspofungin. therefore, the use of mycelial inocula for h. capsulatum antifungal susceptibility testing is suggested, which is less time-consuming vis-à-vis the yeast form, which requires 6 to 8 weeks ... | 2014 | 24982084 |
| disseminated histoplasmosis in allogeneic bone marrow transplant: a diagnosis not to be missed. | immunosuppressed patients are at highest risk for disseminated histoplasmosis, but only a few cases have been reported in hematopoietic stem cell transplant recipients. we report a case of disseminated histoplasmosis in an allogeneic bone marrow transplant recipient residing in a non-endemic area. diagnosis was first suspected based on a peripheral blood smear. | 2014 | 24981307 |
| histoplasmosis as a possible cause of retroperitoneal fibrosis and median arcuate ligament syndrome: a case report. | median arcuate ligament syndrome (mals), a condition of poorly understood etiology, is caused by compression of the celiac artery by fibers of the median arcuate ligament. | 2014 | 24981164 |
| histoplasmosis brain abscesses in an immunocompetent adult. a case report and literature review. | we describe the case of a 62-year-old man, who presented with a new onset of focal seizures of his right leg. there were no other clinical symptoms, and laboratory results were normal. brain magnetic resonance imaging revealed multiple lesions, two supratentorial lesions were ring-enhancing. the brain biopsy tissue showed histoplasma capsulatum abscesses. he improved on treatment with amphotericin b. this case is reported since cerebral ring-enhancing lesions are rarely associated with histoplas ... | 2014 | 24976201 |
| fungal endocarditis observed over an 8-year period and a review of the literature. | fungal endocarditis (fe) is a "modern" disease that is considered an emerging cause of infective endocarditis (ie). the most frequently identified fungal pathogens are candida spp., which are responsible for up to two-thirds of all cases; the remaining cases are due to aspergillus spp., histoplasma capsulatum or, more rarely, other yeasts and moulds. | 2014 | 24965217 |
| cutaneous histoplasmosis in renal transplant recipients. | cutaneous histoplasmosis is a rare entity, although it can be seen in a substantial portion of renal transplant recipients with disseminated disease. the prognosis of disseminated disease is worse than isolated cutaneous involvement, and significant delays in diagnosis are reported. we reviewed reports of cutaneous histoplasmosis with and without dissemination in the setting of renal transplantation to examine incidence, timing of diagnosis, clinical features, and prognosis. remarkable morpholog ... | 2014 | 24961319 |
| dimorphic fungal osteoarticular infections. | the objective of this investigation was to review the clinical manifestations, management, and outcome of osteoarticular infections caused by dimorphic fungi. we exhaustively reviewed reports of bone and joint infections caused by dimorphic fungi published between 1970 and 2012. underlying conditions, microbiological features, histological characteristics, clinical manifestations, antifungal therapy, and outcome were analyzed in 222 evaluable cases. among 222 proven cases (median age 41 years [i ... | 2014 | 24939620 |
| cutaneous ulcer in an immunosuppressed patient with adult onset still's disease: primary cutaneous histoplasmosis? | histoplasmosis is caused by the dimorphic fungus histoplasma capsulatum.primary infection occurs through inhalation of spores from the air. immunocompetent individuals are usually asymptomatic, but may develop pulmonary disease. immunocompromised patients tend to present systemic histoplasmosis with cutaneous lesions occurring by secondary invasion. in this case report, we describe a probable primary cutaneous histoplasmosis (pch) in a patient with adult onset still's disease under immunosuppres ... | 2015 | 24937841 |
| [american histoplasmosis: clinicopathological features in immunocompetent and immunocompromised patients. a report of two cases of infection by histoplasma capsulatum on reunion island]. | histoplasmosis is a fungal infection caused by histoplasma capsulatum var. capsulatum. it shows pulmonary or multivisceral involvement. infective spores are inhaled from soils that contain bat or bird guano. the clinical picture depends on the intensity of the exposure and the immune status of the host. | 2014 | 24878163 |
| histoplasmosis mimicking malignant adenopathy during diagnostic thyroid lobectomy. | benign granulomatous disease may mimic malignant disease in the evaluation of mediastinal or pulmonary lesions. however, histoplasmosis as a cause of cervical lymphadenopathy is relatively rare. we report the first case of histoplasma infection mimicking malignant adenopathy discovered during diagnostic thyroid lobectomy. | 2014 | 24875853 |
| histoplasmosis in hiv-infected patients: a review of new developments and remaining gaps. | histoplasma capsulatum is responsible for histoplasmosis, a fungal disease with worldwide distribution that can affect both immunocompromised and imunocompetent individuals. during the highly active antiretroviral therapy (haart) era, morbidity and mortality due to histoplasmosis remained a public heatlh problem in low-income and high-income countries. the true burden of hiv-associated histoplasmosis is either not fully known or neglected since it is not a notifiable disease. progress has been m ... | 2014 | 24860719 |
| urine antigen tests for the diagnosis of respiratory infections: legionellosis, histoplasmosis, pneumococcal pneumonia. | urinary antigen testing has grown in popularity for several significant respiratory infections, particularly legionella pneumophila, streptococcus pneumoniae, and histoplasma capsulatum. by capitalizing on the concentration of shed antigen from a variety of pathogens in the kidneys for excretion in the urine, urinary antigen testing can be used to obtain rapid test results related to respiratory infection, independent of an invasive collection such as a bronchoalveolar lavage. this article descr ... | 2014 | 24856525 |
| [disseminated histoplasmosis treated by boluses of fluconazole]. | we report a case in which an hiv-infected man was cured of disseminated histoplasmosis (histoplasma capsulatum var duboisii) after treatment by high-dose fluconazole (1,600 mg taken four times daily) for 2 months, combined with active antiretroviral therapy. the choice of fluconazole at this dosage was motivated by its availability as a generic and thus inexpensive medication, the patient's precarious status, and his critical clinical condition. at the end of the second month of treatment, the p ... | 2016 | 24854365 |
| [a 55-year-old woman with cough, fever, swelling of joints, and exanthema after a trip to ecuador]. | a 55-year-old woman presented 18 months after a trip to ecuador with night sweat, malaise, and an unclear lesion of the lung. computed tomography of the lung showed a nodular lesion of 14 mm. antibodies against histoplasma capsulatum were detected in the complement fixation text (cft) and igg western blot. re-examination of a formalin fixed paraffin embedded (ffpe) lung-biopsy revealed yeasts after silver staining, compatible with h. capsulatum , which was verified by extraction and amplificatio ... | 2014 | 24831684 |
| histoplasma capsulatum: more widespread than previously thought. | 2014 | 24778192 | |
| primary cutaneous histoplasmosis simulating molluscum contagiosum. | primary cutaneous histoplasmosis in a hiv positive patient ie isolated cutaneous involvement without any deeper structures is a very rare entity. only a handful cases have been reported worldwide. this patient presented with cutaneous lesion simulating molluscum but histopathology revealed histoplasma capsulatum. the patient had no deep organ involvement. the patient was put on itraconazole which caused rapid dissolution of the lesions. he was subsequently put on haart and discharged. | 2013 | 24772760 |
| usefulness of the murine model to study the immune response against histoplasma capsulatum infection. | the present paper is an overview of the primary events that are associated with the histoplasmosis immune response in the murine model. valuable data that have been recorded in the scientific literature have contributed to an improved understanding of the clinical course of this systemic mycosis, which is caused by the dimorphic fungus histoplasma capsulatum. data must be analyzed carefully, given that misinterpretation could be generated because most of the available information is based on exp ... | 2014 | 24766724 |
| hepatitis and pneumonitis during adalimumab therapy in crohn disease: mind the histoplasmosis! | tumor necrosis factor-alpha (tnf-α) inhibitor therapy plays a pivotal role in the management of moderate to severe inflammatory bowel disease. because of the role of tnf-α in the host defenses, anti-tnf therapy has been associated with an increase the risks of granulomatous infections. | 2015 | 24760069 |
| disseminated histoplasmosis: a comparative study of the clinical features and outcome among immunocompromised and immunocompetent patients. | disseminated histoplasmosis is a chronic granulomatous disease caused by the dimorphic fungus, histoplasma capsulatum. clinical presentation can vary from the acute pulmonary to the chronic disseminated form. in india, disseminated histoplasmosis often presents with pyrexia of unknown origin with a presentation similar to 'disseminated tuberculosis' involving the adrenal glands and bone marrow. due to rarity of the disease, data are lacking regarding its clinical presentation and outcome among i ... | 2014 | 24758444 |
| cognitive impairment and memory loss associated with histoplasmosis: a case study. | histoplasmosis is a rare disease caused by inhalation of the fungus histoplasma capsulatum. it can spread via cerebral circulation to the central nervous system as a manifestation of a disseminated infection; particularly in patients with immune suppression, which can result in isolated ring-enhancing lesions and inflammation in the brain. of the reported disseminated histoplasmosis cases (approximately 1 in 2000 per year), only 5-20% have evidence of central nervous system involvement. this pap ... | 2014 | 24730375 |
| candida albicans sod5 represents the prototype of an unprecedented class of cu-only superoxide dismutases required for pathogen defense. | the human fungal pathogens candida albicans and histoplasma capsulatum have been reported to protect against the oxidative burst of host innate immune cells using a family of extracellular proteins with similarity to cu/zn superoxide dismutase 1 (sod1). we report here that these molecules are widespread throughout fungi and deviate from canonical sod1 at the primary, tertiary, and quaternary levels. the structure of c. albicans sod5 reveals that although the β-barrel of cu/zn sods is largely pre ... | 2014 | 24711423 |
| detection and phylogenetic characterization of a case of histoplasma capsulatum infection in mainland china. | histoplasmosis usually occurs in specific endemic areas. sporadic cases have also been reported in mainland china. here, we described an indigenous case of disseminated histoplasmosis. phylogenetic analysis revealed that the histoplasma capsulatum isolated in our case belongs to the australian clade. combined with previous studies, it revealed high genetic diversity among chinese h. capsulatum isolates. | 2014 | 24686744 |
| bone marrow aspirate showing histoplasma capsulatum. | 2014 | 24678546 | |
| histoplasma capsulatum in new england: a case study. | 2014 | 24669441 | |
| non-resolving pneumonia: a rare presentation of progressive disseminated histoplasmosis. | histoplasmosis, a fungal disease caused by histoplasma capsulatum, is endemic in north and south america. except few scattered cases, the disease is considered to be a non-entity in india. furthermore, disseminated histoplasmosis is rare in the immunocompetent individuals. we report an adolescent boy presenting as middle lobe consolidation which did not respond to antibiotics. his condition deteriorated with the development of mediastinal lymphadenopathy, pleural effusion and hepatosplenomegaly. ... | 2014 | 24669090 |
| 18f-fdg pet as a monitoring tool to assess treatment response in bilateral adrenal histoplasmosis. | a 60-year-old woman with clinical and biochemical features suggestive of adrenal insufficiency was found to have bilateral adrenal masses on ct scan and was subjected to f-fdg pet scan. the scan showed hypermetabolic mediastinal nodes in addition to intense tracer uptake in bilateral adrenal masses. ct-guided adrenal biopsy grew histoplasma capsulatum on sabouraud dextrose agar culture. a second f-fdg pet scan after 6 months of appropriate antifungal therapy showed a significant decrease in inte ... | 2014 | 24662660 |
| in vitro inhibitory effect of miltefosine against strains of histoplasma capsulatum var. capsulatum and sporothrix spp. | miltefosine (mil), originally developed for use in cancer chemotherapy, has been shown to have important antifungal activity against several pathogenic fungi. our aim in this study was to determine the in vitro activity of mil against the dimorphic fungi histoplasma capsulatum and sporothrix spp. this was done using the broth microdilution method. mil had an in vitro inhibitory effect against all strains of h. capsulatum var. capsulatum and sporothrix spp. analyzed. the minimal inhibitory concen ... | 2014 | 24662247 |
| extradural spinal cord lesion in a dog: first case study of canine neurological histoplasmosis in italy. | a 7-year-old intact male mixed dog was presented with a history of acute and progressive paraparesis. abnormal clinical signs consisted of non-ambulatory paraparesis, hind limbs hypertonia and severe thoracolumbar pain. magnetic resonance imaging demonstrated an isointense in t1 and t2 wi epidural lesion, with good contrast enhancement, extending from t-10 to t-13. laminectomy was carried out to remove the epidural mass. histological examination revealed a pyogranulomatous lesion characterized b ... | 2014 | 24646600 |
| [aspergillus galactomannan assay for the management of histoplasmosis due to histoplasma capsulatum var. duboisii in hiv-infected patients: education from a clinical case]. | the diagnosis of histoplasmosis due to histoplasma capsulatum var capsulatum is based on a direct examination identifying encapsulated yeast with narrow-based budding. galactomannan antigenemia facilitates diagnosis, as well as the monitoring of patients receiving treatment. the case of a hiv-positive patient from congo-brazzaville with a disseminated form of african histoplasmosis highlighted the positive galactomannan antigen in this disease due to histoplasma capsulatum var duboisii. galactom ... | 2014 | 24636196 |
| [diagnosing a case of disseminated histoplasmosis with a blood smear]. | 2014 | 24630596 | |
| histoplasmosis mimicking adrenal carcinoma. | the incidence of unilateral adrenal histoplasmosis in nonendemic areas is rare. this is even rarer if the host is immunocompetent. | 2014 | 24600775 |
| fever in hospitalized hiv-infected patients in western french guiana: first think histoplasmosis. | in western french guiana, there was a dramatic increase in hiv prevalence between 1990 and 2000. the present study describes the causes of fever among hiv patients hospitalized in the medical ward of the only hospital in the western part of french guiana. a retrospective descriptive study was conducted between 1 january 2008 and 30 june 2010 in the department of medicine of saint laurent du maroni hospital. the main characteristics of 67 patients having presented with fever in the first 48 hours ... | 2014 | 24598976 |
| dual localization of mdj1 in pathogenic fungi varies with growth temperature. | paracoccidioides brasiliensis and p. lutzii are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis (pcm). previously, we characterized the pbmdj1 gene. this gene encodes p. brasiliensis chaperone mdj1, which in yeast is a mitochondrial member of the j-domain family, whose main function is to regulate cognate hsp70 activities. we produced rabbit polyclonal antibody antirecombinant pbmdj1 (rpbmdj1), which labeled the protein not only in mitochondria but also at the cell wall o ... | 2014 | 24577000 |
| histoplasmosis outbreak in tamboril cave-minas gerais state, brazil. | in this study, we report four cases of histoplasma capsulatum infection in eight biologists who made an expedition to determine the prevalence of this fungus in a cave localized in the northwest of minas gerais state, brazil. this case report demonstrates the importance of evaluating the h. capsulatum presence in brazilian caves before opening to public visitations. | 2014 | 24567897 |
| disseminated histoplasmosis in two juvenile raccoons (procyon lotor) from a nonendemic region of the united states. | two 6-month-old raccoon kits, which had been rescued and fostered in preparation for return to the wild, became acutely ill and died 3 weeks before scheduled release. at necropsy, the kits had grossly enlarged livers and spleens, diffusely consolidated lungs, and generalized lymphadenopathy. histologically, extensive infiltrates of macrophages containing yeast organisms were identified in lung, liver, kidney, spleen, lymph nodes, intestinal tissues, brain, adrenal gland, bone marrow, and thymus ... | 2014 | 24557751 |
| evaluation of the action of nystatin on histoplasma capsulatum in vitro and in hamsters and mice. | 1956 | 24543868 | |
| therapeutic effect of nystatin (fungicidin) in mice experimentally infected with histoplasma capsulatum. | 1954 | 24543014 | |
| synthesis and antifungal activity in vitro of isoniazid derivatives against histoplasma capsulatum var. capsulatum. | histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the americas. amphotericin b (amb) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but amb is toxic, and the bioavailability of itraconazole is erratic. therefore, it is important to investigate new classes of drugs for histoplasmosis treatment. in this study, a series of nine isoniazid hydrazone derivatives were synthesized and evaluated for their ... | 2014 | 24514090 |
| fatal fulminant necrotizing pneumonia: a case report. | here we present the case of a patient with fatal pulmonary histoplasmosis who presented with extensive necrotizing and cavitating pneumonia. to the best of our knowledge, this case report is the first to describe this presentation in a patient with no known immunosuppression. | 2014 | 24499506 |
| histoplasma capsulatum and pneumocystis spp. co-infection in wild bats from argentina, french guyana, and mexico. | histoplasma capsulatum and pneumocystis organisms cause host infections primarily affecting the lung tissue. h. capsulatum is endemic in the united states of america and latin american countries. in special environments, h. capsulatum is commonly associated with bat and bird droppings. pneumocystis-host specificity has been primarily studied in laboratory animals, and its ability to be harboured by wild animals remains as an important issue for understanding the spread of this pathogen in nature ... | 2014 | 24495513 |
| locally acquired disseminated histoplasmosis in a northern sea otter (enhydra lutris kenyoni) in alaska, usa. | histoplasmosis of local origin has not been reported in humans or wildlife in alaska, and the disease has never been reported in a free-ranging marine mammal. in 2005 a northern sea otter (enhydra lutris kenyoni) was found on kodiak island, alaska, at 57° latitude north, far outside the known distribution of histoplasma capsulatum. the animal died of disseminated histoplasmosis. microorganisms consistent with histoplasma sp. were observed on histopathology, and h. capsulatum was identified by pc ... | 2014 | 24484503 |
| development of a loop-mediated isothermal amplification method for detection of histoplasma capsulatum dna in clinical samples. | improved methods for the detection of histoplasma capsulatum are needed in regions with limited resources in which the organism is endemic, where delayed diagnosis of progressive disseminated histoplasmosis (pdh) results in high mortality rates. we have investigated the use of a loop-mediated isothermal amplification (lamp) assay to facilitate rapid inexpensive molecular diagnosis of this disease. primers for lamp were designed to amplify the hcp100 locus of h. capsulatum. the sensitivity and li ... | 2014 | 24478477 |
| a multiplex real-time pcr assay for identification of pneumocystis jirovecii, histoplasma capsulatum, and cryptococcus neoformans/cryptococcus gattii in samples from aids patients with opportunistic pneumonia. | a molecular diagnostic technique based on real-time pcr was developed for the simultaneous detection of three of the most frequent causative agents of fungal opportunistic pneumonia in aids patients: pneumocystis jirovecii, histoplasma capsulatum, and cryptococcus neoformans/cryptococcus gattii. this technique was tested in cultured strains and in clinical samples from hiv-positive patients. the methodology used involved species-specific molecular beacon probes targeted to the internal transcrib ... | 2014 | 24478409 |
| the leukotriene b₄/blt₁ axis is a key determinant in susceptibility and resistance to histoplasmosis. | the bioactive lipid mediator leukotriene b4 (ltb4) greatly enhances phagocyte antimicrobial functions against a myriad of pathogens. in murine histoplasmosis, inhibition of the lt-generating enzyme 5-lypoxigenase (5-lo) increases the susceptibility of the host to infection. in this study, we investigated whether murine resistance or susceptibility to histoplasma capsulatum infection is associated with leukotriene production and an enhancement of in vivo and/or in vitro antimicrobial effector fun ... | 2014 | 24465479 |
| disseminated histoplasmosis (histoplasma capsulatum) in a pet rabbit: case report and review of the literature. | a 2.5-year-old intact male miniature lop rabbit (oryctolagus cuniculus) was presented with multiple nodules surrounding the eyes, nose, mouth, and prepuce. cytological evaluation of the periocular nodules revealed the presence of intracellular (within macrophages) and extracellular yeast organisms. the yeast organisms were approximately 3-5 µm in diameter, round to oval, with a thin clear capsule, and contained an eccentrically placed basophilic crescent-shaped nucleus. the clinical pathological ... | 2014 | 24452788 |
| probable primary cutaneous histoplasmosis in a patient infected with hiv. | histoplasmosis is a fungal infection caused by a dimorphic fungus, histoplasma capsulatum. most infections occur after inhalation of fungal spores. a wide variety of clinical manifestations can occur depending on the host response and the extent of inoculation. we report a case of probable cutaneous histoplasmosis after trauma in a 26-year-old man from paraguay who was also infected with the human immunodeficiency virus. diagnosis was based on histological and mycological examination. no systemi ... | 2011 | 24451565 |
| [disseminated histoplasmosis due to histoplasma capsulatum var. duboisii in senegal. a case in hiv-infected patient]. | histoplasmosis, a disease due to histoplasma capsulatum, is an invasive opportunistic fungal infection, endemic in africa. so, the occurrence of african histoplasmosis associated with hiv infection has been rarely reported despite the high prevalence of both pathogens in this area. we report the first case of disseminated african histoplasmosis in an hiv-infected senegalese patient. | 2011 | 24451506 |
| seven imported histoplasmosis cases due to histoplasma capsulatum var. capsulatum: from few weeks to more than three decades asymptomatic period. | histoplasma capsulatum is a nonendemic fungus in europe. epidemiological, clinical biological features and follow-up of seven imported cases in france were reported. these cases underlined the difficulties of such diagnosis in nonendemic areas due to greatly variable asymptomatic period, and lack of specific clinical signs. thus, anamnesis should be carefully analysed; mucocutaneous signs and immunosuppression should be systematically investigated. biological diagnosis requires multiple sites sa ... | 2011 | 24451498 |
| disseminated histoplasmosis in a domestic cat imported from the usa to austria. | we present a case of disseminated histoplasmosis in a domestic cat imported from the usa to austria. histopathological examination revealed a systemic mycosis with most severe involvement of the lungs suggestive of histoplasma (h.) capsulatum-infection. molecular confirmation was based on polymerase chain reaction (pcr) and sequence analysis of a fungal culture from liver samples. this is the first case of feline histoplasmosis proven by molecular diagnostic technique in europe and reported in a ... | 2013 | 24432230 |
| bats, fever and adenopathy - what is the link? | a case of travel-related, subacute, progressive disseminated histoplasmosis in a nonimmunocompromised individual is described. the present case highlights the environmental exposure to histoplasma capsulatum in costa rica, the diagnostic approach and treatment options, as well as new alternatives for salvage therapy for histoplasmosis infection. | 2013 | 24421791 |
| c-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of north america. | vaccine immunity to the endemic mycoses of north america requires th17 cells, but the pattern recognition receptors and signaling pathways that drive these protective responses have not been defined. we show that c-type lectin receptors exert divergent contributions to the development of antifungal th17 cells and vaccine resistance against blastomyces dermatitidis, histoplasma capsulatum, and coccidioides posadasii. acquired immunity to b. dermatitidis requires dectin-2, whereas vaccination agai ... | 2014 | 24391211 |
| oral histoplasmosis masquerading as oral cancer in hiv-infected patient: a case report. | histoplasmosis is an endemic mycoses caused by histoplasma capsulatum with endemicity around midwestern united states and central america. the endemicity of histoplasmosis in india is not clearly known. histoplasmosis, especially oral histoplasmosis, is now increasingly being reported from india. we report here a culture-confirmed and sequence confirmed, oral histoplasmosis in a hiv seropositive individual who was referred to our regional cancer centre with a suspicion of oral cancer. | 2012 | 24371747 |
| an instructive case of cns histoplasmosis in an immunocompetent host. | histoplasma capsulatum is a dimorphic endemic fungus which infects both immunocompetent and immunocompromised hosts. isolated cns histoplasmosis is a rare presentation with increased risk in individuals with impaired cellular immunity, however not all patients with this condition are immunocompromised. we report a case of isolated cns histoplasmosis in an otherwise healthy immunocompetent patient who was initially treated with liposomal amphotericin b followed by oral voriconazole and later itra ... | 2012 | 24371742 |
| genetic diversity of histoplasma capsulatum strains isolated from argentina based on nucleotide sequence variations in the internal transcribed spacer regions of rdna. | the internal transcribed spacer (its) regions of rdna genes of 49 histoplasma capsulatum (48 from clinical samples and one from soil) isolates were examined. nucleotide sequence heterogeneity within this region was useful for phylogenetic classification of h. capsulatum and species identification. thus, in 45 of 49 isolates we observed higher percentages of identity in the nucleotide sequences of its regions when the isolates studied herein were compared with those reported in our country in the ... | 2014 | 24299459 |
| how many have died from undiagnosed human immunodeficiency virus-associated histoplasmosis, a treatable disease? time to act. | human immunodeficiency virus (hiv)-associated disseminated histoplasma capsulatum capsulatum infection often mimics tuberculosis. this disease is well know in the united states but is dramatically underdiagnosed in central and south america. in the amazon region, given the available incidence data and the regional hiv prevalence, it is expected that, every year, 1,500 cases of histoplasmosis affect hiv patients in that region alone. given the mortality in undiagnosed patients, at least 600 patie ... | 2014 | 24277783 |
| genetic diversity of histoplasma and sporothrix complexes based on sequences of their its1-5.8s-its2 regions from the bold system. | high sensitivity and specificity of molecular biology techniques have proven usefulness for the detection, identification and typing of different pathogens. the its (internal transcribed spacer) regions of the ribosomal dna are highly conserved non-coding regions, and have been widely used in different studies including the determination of the genetic diversity of human fungal pathogens. this article wants to contribute to the understanding of the intra- and interspecific genetic diversity of i ... | 2014 | 24270072 |
| sexual variability in histoplasma capsulatum and its possible distribution: what is going on? | histoplasma capsulatum is a dimorphic fungal pathogen naturally found in the soil. inhalation of conidia can result in pulmonary histoplasmosis and, in some cases, causes severe disseminated disease and death. this fungus is an ascomycete that has an anamorphic or asexual stage and a teleomorphic or sexual stage, known as ajellomyces capsulatus, which results from (+) and (-) mating types. sexual reproduction is regulated by a specialized genomic region known as the mating-type (mat1) locus. the ... | 2014 | 24262630 |
| effect of histoplasma capsulatum glucans on host innate immunity. | β-1,3-glucan is important for infective forms (mycelial phase) of histoplasma capsulatum and shares many features allotted to pathogen-associated molecular patterns. these cell wall carbohydrates interact with phagocytes by binding to toll and lectin-like receptors, present on cell surfaces of macrophages, neutrophils, and dendritic cells. this review focuses on recent findings of the major h. capsulatum and host carbohydrate-driven interactions that account for internalization of fungal infecti ... | 2014 | 24252831 |
| the importance of molecular analyses for understanding the genetic diversity of histoplasma capsulatum: an overview. | advances in the classification of the human pathogen histoplasma capsulatum (h. capsulatum) (ascomycete) are sustained by the results of several genetic analyses that support the high diversity of this dimorphic fungus. the present mini-review highlights the great genetic plasticity of h. capsulatum. important records with different molecular tools, mainly single- or multi-locus sequence analyses developed with this fungus, are discussed. recent phylogenetic data with a multi-locus sequence anal ... | 2014 | 24252830 |
| highlights in pathogenic fungal biofilms. | a wide variety of fungi have demonstrated the ability to colonize surfaces and form biofilms. most studies on fungal biofilms have focused on candida albicans and more recently, several authors have reported the involvement of other genera of yeasts and candida species, as well as of filamentous fungi in the formation of biofilms, including: cryptococcus neoformans, cryptococcus gattii, rhodotorula species, aspergillus fumigatus, malassezia pachydermatis, histoplasma capsulatum, paracoccidioides ... | 2014 | 24252828 |
| [risk factors of invasive fungal infections in patients admitted to non- hematological oncology department and pediatric intensive care unit]. | to determine risk factors of invasive fungal infections (ifi) in patients admitted to non-hematological oncology department and pediatric intensive care unit (picu), in order to improve diagnostic level of invasive fungal infections. | 2013 | 24225291 |
| histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation. | during infection of the mammalian host, histoplasma capsulatum yeasts survive and reside within macrophages of the immune system. whereas some intracellular pathogens escape into the host cytosol, histoplasma yeasts remain within the macrophage phagosome. this intracellular histoplasma-containing compartment imposes nutritional challenges for yeast growth and replication. we identified and annotated vitamin synthesis pathways encoded in the histoplasma genome and confirmed by growth in minimal m ... | 2014 | 24191299 |
| histoplasmosis in a state where it is not known to be endemic--montana, 2012-2013. | histoplasmosis is caused by infection with the dimorphic fungus, histoplasma capsulatum, following inhalation of contaminated soil. among symptomatic patients, the most common clinical presentation is acute pneumonia. persons with compromised immune systems are at risk for disseminated histoplasmosis, a severe illness requiring antifungal therapy that is often characterized by fever, malaise, anorexia, and weight loss. h. capsulatum is endemic in the ohio river and mississippi river valleys, whe ... | 2013 | 24153314 |
| granulocyte macrophage-colony stimulating factor induced zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. | macrophages possess numerous mechanisms to combat microbial invasion, including sequestration of essential nutrients, like zinc (zn). the pleiotropic cytokine granulocyte macrophage-colony stimulating factor (gm-csf) enhances antimicrobial defenses against intracellular pathogens such as histoplasma capsulatum, but its mode of action remains elusive. we have found that gm-csf-activated infected macrophages sequestered labile zn by inducing binding to metallothioneins (mts) in a stat3 and stat5 t ... | 2013 | 24138881 |
| an element of life: competition for zinc in host-pathogen interaction. | zinc homeostasis plays a plethora of different roles in the immune response. in this issue of immunity, vignesh et al. (2013) demonstrate that stimulation of macrophages with gm-csf deprives intracellular histoplasma capsulatum of zinc, improving pathogen clearance. | 2013 | 24138875 |
| a case in europe of feline histoplasmosis apparently limited to the skin. | histoplasma capsulatum has a worldwide distribution, but reports in europe remain rare. we present the second report of histoplasmosis in a cat in europe and, to the best of our knowledge, the first case of feline histoplasmosis infection apparently limited to the skin. | 2013 | 24118343 |
| histoplasma yeast and mycelial transcriptomes reveal pathogenic-phase and lineage-specific gene expression profiles. | the dimorphic fungus histoplasma capsulatum causes respiratory and systemic disease in mammalian hosts by expression of factors that enable survival within phagocytic cells of the immune system. histoplasma's dimorphism is distinguished by growth either as avirulent mycelia or as pathogenic yeast. geographically distinct strains of histoplasma differ in their relative virulence in mammalian hosts and in production of and requirement for specific virulence factors. the close similarity in the gen ... | 2013 | 24112604 |
| iron uptake and virulence in histoplasma capsulatum. | histoplasma capsulatum (hc) is the causative organism of a spectrum of disease affecting both the immunocompetent and the immunocompromised host. hc is a dimporhic fungus that converts from conidia to the pathogenic yeast phase after entry into the mammalian host. despite rapid ingestion by macrophages, it survives intracellularly within the macrophage. the intracellular survival strategy of hc yeasts focuses on regulating the phagosomal compartment by modulating the intraphagosomal ph to 6.5. a ... | 2013 | 24094809 |
| [malian first observation of disseminated african histoplasmosis with predominant bone localizations in an hiv-negative child in bamako (mali). review of the literature]. | endemic deep fungal infections are still under recognised diseases in daily medical practice because of their rarity in sub-saharan area. the african histoplasmosis histoplasma capsulatum var. duboisii (h. capsulatum duboisii) is the most frequent variety described in mali through limited studies in adult patients, since the first case described by catanei and kervran (1945). our case report is a disseminated histoplasmosis in a young 6-year-old african child. he was male and rural. the infectio ... | 2014 | 24094479 |
| n-acetylglucosamine (glcnac) triggers a rapid, temperature-responsive morphogenetic program in thermally dimorphic fungi. | the monosaccharide n-acetylglucosamine (glcnac) is a major component of microbial cell walls and is ubiquitous in the environment. glcnac stimulates developmental pathways in the fungal pathogen candida albicans, which is a commensal organism that colonizes the mammalian gut and causes disease in the setting of host immunodeficiency. here we investigate glcnac signaling in thermally dimorphic human fungal pathogens, a group of fungi that are highly evolutionarily diverged from c. albicans and ca ... | 2013 | 24068964 |
| detection of environmental sources of histoplasma capsulatum in chiang mai, thailand, by nested pcr. | histoplasmosis is a systemic mycosis caused by inhaling spores of histoplasma capsulatum, a dimorphic fungus. this fungus grows in soil contaminated with bat and avian excreta. each year, patients with disseminated histoplasmosis have been diagnosed in chiang mai, northern thailand. no published information is currently available on the environmental sources of this fungus in chiang mai or anywhere else in thailand. the aim of this study was to detect h. capsulatum in soil samples contaminated w ... | 2013 | 24030846 |
| a 20-year-old woman with headache and transient numbness. | 2013 | 23983894 | |
| histoplasmosis in immunocompetent individuals living in an endemic area in the brazilian southeast. | the distribution of infection by histoplasma capsulatum in brazil is heterogeneous, and the number of cases affecting immunocompetent individuals is relatively small. this study reports the epidemiological and clinical data regarding histoplasmosis in non-immunosuppressed individuals. | 2013 | 23982099 |
| evaluation of an enzyme immunoassay for detection of histoplasma capsulatum antigen from urine specimens. | detection of histoplasma capsulatum urinary antigen (uag) is important for the initial diagnosis of infection and for monitoring of patient responses to antifungal therapy. this study evaluated an analyte-specific reagent (asr) enzyme immunoassay (eia) for the detection of h. capsulatum uag from immuno mycologics, inc. (immy) (norman, ok) in comparison with routine testing with the miravista (mvista) h. capsulatum quantitative eia (miravista diagnostics, indianapolis, in). using prospectively co ... | 2013 | 23966508 |
| a temperature-responsive network links cell shape and virulence traits in a primary fungal pathogen. | survival at host temperature is a critical trait for pathogenic microbes of humans. thermally dimorphic fungal pathogens, including histoplasma capsulatum, are soil fungi that undergo dramatic changes in cell shape and virulence gene expression in response to host temperature. how these organisms link changes in temperature to both morphologic development and expression of virulence traits is unknown. here we elucidate a temperature-responsive transcriptional network in h. capsulatum, which swit ... | 2013 | 23935449 |
| histoplasma infection of aortofemoral bypass graft. | histoplasma infection of vascular grafts is extremely rare. to our knowledge, there are only 4 cases reported with histoplasma capsulatum infection of the aortic graft. all had previous disseminated histoplasmosis and atherosclerotic peripheral vascular disease. they were treated surgically with explantation of the infected graft and reimplantation of new graft in extra-anatomic uninfected site. the authors present a new case of h capsulatum infection of aortofemoral bypass graft, but unlike the ... | 2014 | 23928546 |
| vulvar histoplasmosis as a rare cause of genital ulceration. | histoplasmosis is an infection caused by the dimorphic fungus histoplasma capsulatum and primarily presents with pulmonary symptoms. immunocompromised individuals are at high risk for contracting disseminated histoplasmosis, which can be fatal if left untreated. | 2013 | 23884256 |
| granulomatous rhinitis due to candida parapsilosis in a cat. | a 9-year-old female spayed domestic medium hair cat presented to the referring veterinarian with a 2-week history of sneezing, which progressed to swelling over the nasal planum. the cat had been under veterinary care for inflammatory bowel disease and had been treated with 1.25 mg/kg prednisolone once a day for approximately 1 year. on physical examination, an approximately 2-3 mm diameter, round polypoid pink soft-tissue mass was protruding slightly from the right nostril. through histologic e ... | 2013 | 23883665 |
| [histoplasma capsulatum var. capsulatum darling]. | 2013 | 23877779 |