Publications

preliminary evaluation of some wild and cultivated plants for snail control in machakos district, kenya.	fifty local medicinal, agricultural and wild growing deciduous plants, representing 49 species, 46 genera and 22 families, were screened as water extracts at 1:1000 concentration for molluscicidal activity against biomphalaria pfeifferi in machakos district, kenya. forty-seven of the 50 (94%) plants and 106 of the 134 (79%) plant materials (roots, stems, leaves, fruits, flowers and seeds) were molluscicidal. the leaves of pappea capensis (sapindaceae), steganotaenia araliacea (umbelliferae), zor ...	1987	3656497
rapid, random evolution of the genetic structure of replicating tobacco mosaic virus populations.	the effects of temperature and type of host on the evolution of variants in replicating populations of tobacco mosaic virus (tmv) originating from an in vitro rna transcript of a cdna clone were studied. the phenotypic markers measured were temperature-sensitive (ts) replication and induction of necrotic local lesions (nl) on nicotiana sylvestris. the proportions of ts variants were about the same under all conditions tested, but changes in temperature or host had strong effects on proportions o ...	1989	2777537
evaluation of the gastric antiulcerogenic effects of solanum nigrum, brassica oleracea and ocimum basilicum in rats.	antiulcerogenic activities of three plant drugs were studied against aspirin-induced gastric ulcers in rats. in addition, their effects on output of gastric acid and pepsin and hexosamine concentrations in gastric fluid were recorded in ulcerated and non-ulcerated rats. solanum nigrum (aerial parts) powder and its methanolic extract decreased the ulcer index significantly. the activity may be due to inhibition of acid and pepsin secretions and/or their in vitro ability to bind these. brassica ol ...	1989	2515396
regulation of expression of a wound-inducible tomato inhibitor i gene in transgenic nightshade plants.	a wound-inducible proteinase inhibitor i gene from tomato containing 725 bp of the 5' region and 2.5 kbp of the 3' region was stably incorporated into the genome of black nightshade plants (solanum nigrum) using an agrobacterium ti plasmid-derived vector. transgenic nightshade plants were selected that expressed the tomato inhibitor i protein in leaf tissue. the leaves of the plants contained constitutive levels of the inhibitor protein of up to 60 micrograms/g tissue. these levels increased by ...	1990	2102819
effect of the leafy vegetable solanum nigrum on the activities of some liver drug-metabolizing enzymes after aflatoxin b1 treatment in female rats.	wistar albino female rats were maintained for 10 d on diets containing various levels of the vegetable solanum nigrum. simultaneously, they received daily intraperitoneal injections of aflatoxin b1 (afb1) (either 0.2 or 0.4 mg/kg body-weight) diluted in propylene glycol. at the end of the experiment, all animals were killed and their serum and hepatic microsomes were prepared for assay of enzymes. results showed that aminopyrine n-demethylase activity increased 2.5-fold with 200 (s200) and 600 ( ...	1991	1900029
a case-control study of diet and social factors in cancer of the esophagus in transkei.	a study of 100 patients with cancer of the esophagus and 100 controls matched for sex, age, and educational level was done in transkei, with extensive inquiries into diet and social habits. the significant risk factors found were use of solanum nigrum as a food (relative risk, 3.6), smoking (relative risk, 2.6), and use of traditional medicines (relative risk, 2.1). consumption of traditional beer was not a risk factor.	1992	1735077
differential expression of a chimeric camv-tomato proteinase inhibitor i gene in leaves of transformed nightshade, tobacco and alfalfa plants.	the open reading frame and terminator region of a wound-inducible tomato inhibitor i gene, regulated by the camv 35s promoter, was stably integrated into the genomes of nightshade (solanum nigrum), tobacco (nicotiana tabacum), and alfalfa (medicago sativa), using an agrobacterium-mediated transformation system. the expression of the foreign inhibitor i gene in leaves of each species was studied at the mrna and protein levels. the levels of inhibitor i protein present in leaves of each species co ...	1992	1463848
acetylcholine-like activity in the fruit of the black nightshade (solanaceae).	the presence of acetylcholine in aqueous extracts of the fruit of solanum nigrum linn. (black nightshade) has been established based upon the following pharmacological tests: a) isotonic contraction of the isolated toad rectus abdominis; b) negative chronotropic and inotropic action on the isolated toad heart; c) isotonic contraction of the isolated guinea pig's ileum; d) isotonic contraction of the rat's isolated jejunum; 3) decrease on the cat's arterial blood pressure; f) secretory effects on ...	1978	122174