Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| rhinovirus-bacteria co-exposure synergistically induces ccl20 production from human bronchial epithelial cells. | exacerbations of chronic obstructive pulmonary disease (copd) are triggered by viral or bacterial pathogens, with human rhinovirus (hrv) and nontypeable haemophilus influenzae (nthi) among the most commonly detected pathogens. patients who suffer from concomitant viral and bacterial infection have more severe exacerbations. the airway epithelial cell is the initial site of viral and bacterial interactions, and ccl20 is an epithelial chemokine that attracts immature dendritic cells to the airways ... | 2017 | 28283475 |
| haemophilus influenzae isolated from men with acute urethritis: its pathogenic roles, responses to antimicrobial chemotherapies, and antimicrobial susceptibilities. | there have been few comprehensive studies on haemophilus influenza-positive urethritis. | 2017 | 28282645 |
| discharge and infection in retinoblastoma post-enucleation sockets. | to investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (rb). | 2017 | 28280296 |
| prevention of influenza virus induced bacterial superinfection by standardized echinacea purpurea, via regulation of surface receptor expression in human bronchial epithelial cells. | viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may c ... | 2017 | 28279802 |
| nontypeable haemophilus influenzae-promoted proliferation of kras-induced early adenomatous lesions is completely dependent on toll-like receptor signaling. | chronic obstructive pulmonary disease is a risk factor for lung cancer. copd is characterized by chronic airway inflammation and lung infections. the airways of patients with copd are frequently colonized with bacteria [eg, nontypeable haemophilus influenzae (nthi)] that cause pulmonary inflammation and exacerbations. pulmonary adenocarcinomas are frequently associated with an activating mutation in the kras gene. we determined the function of toll-like receptor (tlr) signaling on the progressio ... | 2017 | 28279655 |
| infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves. | this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves. | 2017 | 28279319 |
| the immunogenicity and safety of a hib-menac vaccine: a non-inferiority randomized, observer-blind trial in infants aged 3-5 months. | the objective of this study was to evaluate the immunogenicity and safety of the novel combined haemophilus influenzae type b-neisseria meningitidis serogroup a and c-tetanus toxoid conjugate vaccine (hib-menac). | 2017 | 28277801 |
| il-33/st2 immune responses to respiratory bacteria in pediatric asthma. | here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the eu-wide study predicta. in this cohort of pre-school asthmatic children, nasopharyngeal colonization with gram-negative bacteria such as haemophilus influenzae and moraxella catarrhalis was found to be associated with the highest interferon beta (ifnβ) and il-33 levels in the nasal pharyngeal fluids (npf). il33r-st2 was found induc ... | 2017 | 28262704 |
| persistent and recurrent bacterial bronchitis-a paradigm shift in our understanding of chronic respiratory disease. | the recent recognition that the conducting airways are not "sterile" and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respiratory diseases (such as chronic bronchitis, sinusitis, and chronic otitis media), permit us to update the "vicious circle" hypothesis of the causation of bronchiectasis. this proposes that chronic inflammation driven by persistent bacterial bronchitis (pbb) causes ... | 2017 | 28261574 |
| characterisation of invasive clinical haemophilus influenzae isolates in queensland, australia using whole-genome sequencing. | haemophilus influenzae is an important aetiological organism of both adult and child respiratory disease. the number of non-typeable (nthi) invasive h. influenzae isolates referred to the queensland (qld) public health microbiology laboratory has increased notably year-by-year. in this study we used whole-genome sequencing to molecularly characterise 100 referred invasive h. influenzae, including 74 nthi isolates over a 15-year period, observing the carriage of capsular and putative virulence ge ... | 2017 | 28260537 |
| community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. | mechanically ventilated patients are at risk for developing ventilator-associated pneumonia, and it has been reported that dental plaque provides a reservoir of respiratory pathogens that may aspirate to the lungs and endotracheal tube (ett) biofilms. for the first time, metataxonomics was used to simultaneously characterize the microbiome of dental plaque, etts, and non-directed bronchial lavages (nbls) in mechanically ventilated patients to determine similarities in respective microbial commun ... | 2017 | 28259058 |
| nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | we reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. we also showed defects in phagocytosis of nontypeable haemophilus influenzae (nthi), a common colonizer of the lower airway in these diseases. these defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. the aim of t ... | 2017 | 28258107 |
| design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. | erythromycin was long viewed as a bacteriostatic agent. the erythromycin derivatives, 9-oxime ketolides have a species-specific bactericidal profile. among them, the 3'-allyl version of the 9-oxime ketolide 1 (ar=3-quinolyl; 17a) is bactericidal against streptococcus pneumoniae and streptococcus pyogenes. in contrast, the 2-fluoro analogs of 1, 13a (ar=6-quinolyl), 13b (ar=3-quinolyl) and 24a (ar=4-isoquinolyl), show bactericidal activities against s. pneumoniae, staphylococcus aureus and moraxe ... | 2017 | 28256375 |
| non-typeable haemophilus influenzae infection of the junbo mouse. | acute otitis media, inflammation of the middle ear bulla, is the most common bacterial infection in children. for one of the principal otopathogens, non-typeable haemophilus influenzae (nthi), animal models allow us to investigate host-microbial interactions relevant to the onset and progression of infection and to study treatment of middle ear disease. we have established a robust model of nthi middle ear infection in the junbo mouse. intranasal inoculation with nthi produces high rates of bull ... | 2017 | 28252201 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| a rare case of candida epiglottitis in an immunocompetent child. | we present a case of acute candida epiglottitis in an otherwise healthy and haemophilus influenzae type b-immunized 4-year-old child. a query of the literature reveals this disease to be commonly found in patients who are immunocompromised by problems including human immunodeficiency virus disease and lymphoma and leukemia. however, there are no published reports of acute candida epiglottitis in immunocompetent and vaccinated patients. our case should emphasize to the emergency physician the nee ... | 2017 | 28248840 |
| designing novel construction for cell surface display of protein e on escherichia coli using non-classical pathway based on lpp-ompa. | today, transference of recombinant protein on the outer surface of bacteria is deemed as a valuable process for various applications in biotechnology including preparation of vaccines. in this study, lpp-ompa structure was used to present outer membrane protein e of haemophilus influenzae on e. coli outer membrane. also, a structure was designed according to lpp-ompa based on non-classical secretion pathway using bioinformatics software such as memsat-svm, scrotump and signalp where it lacked an ... | 2017 | 28247289 |
| biodegradation of picolinic acid by a newly isolated bacterium alcaligenes faecalis strain jq135. | we isolated a bacterial strain jq135 from municipal wastewater, which was capable of efficiently degrading picolinic acid (pa). based on the physico-biochemical characteristics and 16s rdna analysis, strain jq135 was identified as alcaligenes faecalis. in addition, strain jq135 produced an orange pigment when cultured in the luria-bertani medium, which is different from the previously reported strains of a. faecalis. during the degradation of pa by the resting strain jq135 cells, only one interm ... | 2017 | 28243718 |
| an isolate of haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) frequently colonises the upper respiratory tract and is an important cause of respiratory infections. resistance to antibiotics is an emerging trend in nthi and alternative prevention or treatment strategies are required. haemophilus haemolyticus is a common commensal occupying the same niche as nthi and, if able to produce substances that inhibit nthi growth, may have a role as a probiotic. in this study, ammonium sulphate extracts from broth culture of ... | 2017 | 28242259 |
| simultaneous detection of nine key bacterial respiratory pathogens using luminex xtag(®) technology. | early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (lrtis). in this study, we developed an assay combining multiplex pcr and luminex technology (mplt) for the detection of nine important respiratory bacterial pathogens, which frequently cause lrtis. these were streptococcus pneumoniae, moraxella catarrhalis, staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae, mycoplasma pneumoniae, legionella spp., pseudomonas aeruginosa, and klebsie ... | 2017 | 28241513 |
| effect of ebola virus disease on maternal and child health services in guinea: a retrospective observational cohort study. | the 2014 west african epidemic of ebola virus disease posed a major threat to the health systems of the countries affected. we sought to quantify the consequences of ebola virus disease on maternal and child health services in the highly-affected forest region of guinea. | 2017 | 28237252 |
| patients hospitalized with an infective exacerbation of bronchiectasis unrelated to cystic fibrosis: clinical, physiological and sputum characteristics. | bronchiectasis is a growing health burden both globally and in australasia. associated with repeated respiratory infections, the disease often results in hospital admission, impaired quality of life, reduced lung function and shortened life expectancy. we describe the local clinical, physiological and sputum characteristics in patients hospitalized with an infective exacerbation of bronchiectasis. | 2017 | 28236369 |
| characteristics of ci children with complicated middle ear infections. | to describe cases of complicated middle ear infections in children with cochlear implants (ci), i.e., episodes of acute otitis media (aom) and acute mastoiditis (am), resulting in hospitalization. | 2017 | 28235386 |
| use of cerebrospinal fluid and serum samples impregnated on ftatm elute filter paper for the diagnosis of infections caused by neisseria meningitidis, streptococcus pneumoniae and haemophilus influenzae. | the lack of information regarding the burden of acute bacterial meningitis in latin america leads to a reduction in the estimated incidence rates of the disease, and impairs public health decisions on the use and follow-up of preventive interventions, particularly, the evaluation of existing vaccination policies. the use of the real-time pcr in diagnostic routine procedures has resulted in a substantial increase in confirmed bacterial meningitis cases. however, in resource-poor countries, these ... | 2017 | 28235065 |
| bacterial aetiology and mortality in copd patients with cap: results from the german competence network, capnetz. | community-acquired pneumonia (cap) is a major cause of morbidity and mortality, and chronic obstructive pulmonary disease (copd) is a frequent comorbidity. the bacterial aetiology of cap-copd and its possible associations with serum markers and mortality are incompletely understood. | 2017 | 28234091 |
| characteristics of invasive haemophilus influenzae serotype a (hia) from nunavik, canada and comparison with hia strains in other north american arctic regions. | this study examines the microbiological characteristics of invasive haemophilus influenae serotype a (hia) isolates from nunavik (northern quebec), canada. the relationship between invasive hia isolates from nunavik, nunavut, canada, and alaska, usa will be discussed. | 2017 | 28232014 |
| pro-inflammatory cytokines impair vitamin d-induced host defense in cultured airway epithelial cells. | vitamin d is a regulator of host defense against infections and induces expression of the antimicrobial peptide hcap18/ll-37. vitamin d deficiency is associated with chronic inflammatory lung diseases and respiratory infections. however, it is incompletely understood if and how (chronic) airway inflammation affects vitamin d metabolism and action. we hypothesized that long-term exposure of primary bronchial epithelial cells (pbec) to pro-inflammatory cytokines alters their vitamin d metabolism, ... | 2017 | 28231019 |
| comparison of pathogen eradication rate and safety of anti-bacterial agents for bronchitis: a network meta-analysis. | a large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. we are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis. | 2017 | 28230273 |
| three case reports of post immunization and post viral bullous pemphigoid: looking for the right trigger. | bullous pemphigoid (bp) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. | 2017 | 28228112 |
| invasive haemophilus influenzae disease in the vaccine era in rio de janeiro, brazil. | haemophilus influenzae (hi) serotype b (hib) conjugate vaccine was incorporated into the infant immunisation schedule in brazil in 1999, where hib was one of the major etiologic sources of community-acquired bacterial meningitis. | 2017 | 28225904 |
| invasive haemophilus influenzae disease in the vaccine era in rio de janeiro, brazil. | haemophilus influenzae (hi) serotype b (hib) conjugate vaccine was incorporated into the infant immunisation schedule in brazil in 1999, where hib was one of the major etiologic sources of community-acquired bacterial meningitis. | 2017 | 28225898 |
| surveillance of omadacycline activity tested against clinical isolates from a global (north america, europe, latin america and asia-western pacific) collection (2010-2011). | omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. in this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in asia-pacific (11,397 isolates), europe (23,490 isolates), latin america (8,038 isolates) and no ... | 2017 | 28223386 |
| evaluation of antibacterial potential and toxicity of plant volatile compounds using new broth microdilution volatilization method and modified mtt assay. | with aim to develop effective proof-of-concept approach which can be used in a development of new preparations for the inhalation therapy, we designed a new screening method for simple and rapid simultaneous determination of antibacterial potential of plant volatiles in the liquid and the vapour phase at different concentrations. in addition, eva (ethylene vinyl acetate) capmat™ as vapour barrier cover was used as reliable modification of thiazolyl blue tetrazolium bromide (mtt) assay for cytoto ... | 2017 | 28223069 |
| effect of stepwise perinatal immunization education: a cluster-randomized controlled trial. | perinatal immunization education is important for improving the immunization outcomes of infants; however, the content of educational materials used at each perinatal period has not been carefully evaluated. we hypothesized that stepwise education offered at different perinatal periods would improve infant immunization status and enhance maternal immunization knowledge. | 2017 | 28222999 |
| epidemiology of invasive haemophilus influenzae disease, europe, 2007-2014. | we describe the epidemiology of invasive haemophilus influenzae disease during 2007-2014 in 12 european countries and assess overall h. influenzae disease trends by serotype and patient age. mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% ci 2.3% to 4.3%). the notification rate was highest for patients <1 month of age (23.4 cases/100,000 population). nontypeable h. influenzae (nthi) caused 78% of all cases and showed increasing trends ... | 2017 | 28220749 |
| biofilm formation of achromobacter xylosoxidans on contact lens. | achromobacter spp. may contaminate lenses, lens cases, and contact lens solutions and cause ocular infections. the aim of this study was to investigate the possibility of isolated strain of achromobacter xylosoxidans to form biofilm on the surface of soft contact lenses (cl), to quantify the production of the formed biofilm, and compare it with the reference strains (pseudomonas aeruginosa, staphylococcus aureus, and haemophilus influenzae). bacterial strain isolated from one contact lens case w ... | 2017 | 28218002 |
| splenectomy as a destination: improving quality of care among asplenic veterans through a travel clinic. | asplenic patients are at risk for severe infections, but adherence to recommended preventive education and vaccination is poor. the goal of this study was to demonstrate that a targeted intervention can improve vaccination rates in a population of asplenic veterans. | 2017 | 28213046 |
| question les parents d’un petit garçon de 12 mois accompagnent leur fils à ma pratique familiale pour sa visite de puériculture. comme l’enfant est dû pour sa série vaccinale de 12 mois, les parents s’inquiètent parce qu’ils ont entendu parler d’un lien entre certains vaccins et un risque accru de convulsions fébriles, et ils se demandent s’ils devraient administrer un antipyrétique en prophylaxie pour réduire le risque. quels vaccins sont liés à un risque accru de convulsions fébriles, et exist ... | 2017 | 28209698 | |
| prophylactic antipyretics for prevention of febrile seizures following vaccination. | question parents of a 12-month-old boy are bringing their son in to my family practice clinic for his well-baby visit. as the infant is due for his 12-month vaccine series, the parents are concerned after hearing about the association between certain vaccinations and an increased risk of febrile seizures, and are wondering if they should administer prophylactic antipyretics to decrease the risk of febrile seizure. what vaccinations are associated with increased risk of febrile seizure, and is th ... | 2017 | 28209678 |
| recommended immunization schedule for children and adolescents: immunization guideline (8th edition) released by the korean pediatric society in 2015. | this report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) immunization guidelines released by the committee on infectious diseases of the korean pediatric society (kps). notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of haemophilus influenzae type b vaccine, pne ... | 2016 | 28194210 |
| diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection. | screening for primary immunodeficiencies (pids) in adults is recommended after two severe bacterial infections. we aimed to evaluate if screening should be performed after the first invasive infection in young adults. | 2017 | 28192236 |
| adherence to vaccination guidelines post splenectomy: a five year follow up study. | following a splenectomy patients are at increased risk of significant infections. in its most severe form, overwhelming post-splenectomy infection (opsi) has a mortality rate of up to 80%. in this study we aim to establish the adherence to vaccination and antibiotic national guidelines in splenectomised patients. a retrospective study of 100 patients who underwent splenectomy (21 emergency, 79 elective), in two teaching hospitals was undertaken over a five-year period. patients were followed up ... | 2017 | 28189514 |
| increased glycosylation efficiency of recombinant proteins in escherichia coli by auto-induction. | escherichia coli cells have been considered as promising hosts for producing n-glycosylated proteins since the successful production of n-glycosylated protein in e. coli with the pgl (n-linked protein glycosylation) locus from campylobacter jejuni. however, one hurdle in producing n-glycosylated proteins in large scale using e. coli is inefficient glycan glycosylation. in this study, we developed a strategy for the production of n-glycosylated proteins with high efficiency via an optimized auto- ... | 2017 | 28188786 |
| do we need a vaccine against moraxella catarrhalis in chronic lung disease? what are the options and opportunities? | moraxella catarrhalis is the second most common cause of exacerbations in adults with copd, resulting in enormous morbidity and mortality in this clinical setting. vaccine development for m. catarrhalis has lagged behind the other two important causes of exacerbations in copd, nontypeable haemophilus influenzae and streptococcus pneumoniae. while no licensed vaccine is currently available for m. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and ... | 2017 | 28185742 |
| modeling the potential for vaccination to diminish the burden of invasive non-typhoidal salmonella disease in young children in mali, west africa. | in sub-saharan africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal salmonella (nts) to be a major pathogen exhibiting high case fatality (~20%). where infant vaccination against haemophilus influenzae type b (hib) and streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in bamako, mali, their burden has decreased markedly. in parallel, nts has become ... | 2017 | 28182657 |
| serum resistance and phase variation of a nasopharyngeal non-typeable haemophilus influenzae isolate. | haemophilus influenzae harbours a complex array of factors to resist human complement attack. as non-typeable h. influenzae (nthi) strains do not possess a capsule, their serum resistance mainly depends on other mechanisms including los decoration. in this report, we describe the identification of a highly serum resistant, nasopharyngeal isolate (nthi23) by screening a collection of 77 clinical isolates. for nthi23, we defined the mlst sequence type 1133, which matches the profile of a previousl ... | 2017 | 28179078 |
| invasive haemophilus influenzae infection in patients with cancer. | a major cause of morbidity and mortality in patients with cancer is infection. since the introduction of the haemophilus influenzae type b (hib) vaccine in the united states in the 1990s, invasive h influenzae infection has become less common. we report on 5 patients with cancer and invasive h influenzae infection. a literature review was also performed of the dominant haemophilus subtype and the clinical features associated with the infection and concomitant cancer. of the 17 cases found in the ... | 2017 | 28178716 |
| the impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: secondary analysis of a randomised controlled trial. | chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. it has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. | 2017 | 28178298 |
| etiology of acute otitis media and serotype distribution of streptococcus pneumoniae and haemophilus influenzae in chilean children <5 years of age. | the impact of bacterial conjugate vaccines on acute otitis media (aom) is affected by several factors including population characteristics, bacterial etiology and vaccine conjugation method, carrier, and coverage. this study estimated the baseline etiology, distribution, and antibiotic susceptibility of bacterial serotypes that causes aom in children aged <5 years in a public setting in santiago, chile.children aged ≥3 months and <5 years referred to the physician for treatment of aom episodes ( ... | 2017 | 28178138 |
| the crystal structure of pd1, a haemophilus surface fibril domain. | the haemophilus surface fibril (hsf) is an unusually large trimeric autotransporter adhesin (taa) expressed by the most virulent strains of h. influenzae. hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. while recent research has suggested that this taa might adopt a novel `hairpin-like' architecture, the characterization of hsf has been limited to in silico modelling and electron ... | 2017 | 28177321 |
| antibacterial defense of human airway epithelial cells from chronic obstructive pulmonary disease patients induced by acute exposure to nontypeable haemophilus influenzae: modulation by cigarette smoke. | antimicrobial proteins and peptides (amps) are a central component of the antibacterial activity of airway epithelial cells. it has been proposed that a decrease in antibacterial lung defense contributes to an increased susceptibility to microbial infection in smokers and patients with chronic obstructive pulmonary disease (copd). however, whether reduced amp expression in the epithelium contributes to this lower defense is largely unknown. we investigated the bacterial killing activity and expr ... | 2017 | 28171878 |
| longitudinal assessment of sputum microbiome by sequencing of the 16s rrna gene in non-cystic fibrosis bronchiectasis patients. | bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. however, the evidence base for antibiotic therapy is limited. dna based methods offer better identification and quantification of microbial constituents of sputum than standard clinical culture and may help inform patient management strategies. our study objective was to determine the longitudinal variability of the non-cystic fibrosis (cf) bronchiectasis microbiome in sputum with respect to clinical ... | 2017 | 28170403 |
| branimycins b and c, antibiotics produced by the abyssal actinobacterium pseudonocardia carboxydivorans m-227. | two new antibiotics, branimycins b (2) and c (3), were produced by fermentation of the abyssal actinobacterium pseudonocardia carboxydivorans m-227, isolated from deep seawater of the avilés submarine canyon. their structures were elucidated by hrms and nmr analyses. these compounds exhibit antibacterial activities against a panel of gram-positive bacteria, including corynebacterium urealyticum, clostridium perfringens, and micrococcus luteus, and against the gram-negative bacterium neisseria me ... | 2017 | 28169531 |
| high pneumonia lifetime-ever incidence in beijing children compared with locations in other countries, and implications for national pcv and hib vaccination. | to compare the proportion of beijing children who have ever had pneumonia (%pneumonia) to those in other locations, and to estimate by how much national vaccine coverage with pneumococcal conjugate vaccine (pcv) and haemophilus influenzae type b (hib) could reduce beijing %pneumonia. | 2017 | 28166256 |
| an investigation of the frequency of upper respiratory tract infection pathogens and their antibiotic patterns in tonsils and adenoids of adenotonsillectomy patients. | we aimed to investigate the potentially pathogenic bacteria of upper respiratory tract infections (urtis) and their susceptibilities to different antibiotics. | 2016 | 28164610 |
| emergence of quinolone-resistant strains in streptococcus pneumoniae isolated from paediatric patients since the approval of oral fluoroquinolones in japan. | tosufloxacin (tflx) is a fluoroquinolone antimicrobial agent. tflx granules for children were initially released in japan in 2010 to treat otitis media and pneumonia caused by drug-resistant bacteria, e.g. penicillin-resistant streptococcus pneumoniae and beta-lactamase-negative, ampicillin-resistant haemophilus influenzae. the evolution of bacterial resistance since tflx approval is not known. to clarify the influence of quinolones administered to children since their approval, we examined the ... | 2017 | 28159338 |
| procalcitonin accurately identifies hospitalized children with low risk of bacterial community-acquired pneumonia. | lower procalcitonin (pct) concentrations are associated with reduced risk of bacterial community-acquired pneumonia (cap) in adults, but data in children are limited. | 2017 | 28158460 |
| laboratory characterization of invasive haemophilus influenzae isolates from nunavut, canada, 2000-2012. | background with invasive haemophilus influenzae serotype b (hib) disease controlled by vaccination with conjugate hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge. objective this study characterized invasive h. influenzae (hi) isolates from nunavut, canada, in the post-hib vaccine era. methods invasive h. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public healt ... | 2016 | 28156415 |
| evaluation of introduction of the haemophilus influenzae vaccine in côte d’ivoire | introduction: côte d’ivoire introduced the haemophilus influenzae type b vaccine into the epi in march 2009. following this introduction, an evaluation was conducted in 2012 in order to evaluate the vaccine introduction process. methods: data collection methods consisted of document review, structured interviews and direct observation. this study collected information from six health region officials, 12 health districts and 36 healthcare institutions. seventy-two mothers or child carers were al ... | 2016 | 28155742 |
| australian aboriginal children with otitis media have reduced antibody titers to specific nontypeable haemophilus influenzae vaccine antigens. | indigenous populations experience high rates of otitis media (om), with increased chronicity and severity, compared to those experienced by their nonindigenous counterparts. data on immune responses to otopathogenic bacteria in these high-risk populations are lacking. nontypeable haemophilus influenzae (nthi) is the predominant otopathogen in australia. no vaccines are currently licensed to target nthi; however, protein d (pd) from nthi is included as a carrier protein in the 10-valent pneumococ ... | 2017 | 28151410 |
| prelp enhances host innate immunity against the respiratory tract pathogen moraxella catarrhalis. | respiratory tract infections are one of the leading causes of mortality worldwide urging better understanding of interactions between pathogens causing these infections and the host. here we report that an extracellular matrix component proline/arginine-rich end leucine-rich repeat protein (prelp) is a novel antibacterial component of innate immunity. we detected the presence of prelp in human bronchoalveolar lavage fluid and showed that prelp can be found in alveolar fluid, resident macrophages ... | 2017 | 28148731 |
| epidemiology of otitis media with spontaneous perforation of the tympanic membrane in young children and association with bacterial nasopharyngeal carriage, recurrences and pneumococcal vaccination in catalonia, spain - the prospective hermes study. | the epidemiology of otitis media with spontaneous perforation of the tympanic membrane and associated nasopharyngeal carriage of bacterial otopathogens was analysed in a county in catalonia (spain) with pneumococcal conjugate vaccines (pcvs) not included in the immunization programme at study time. a prospective, multicentre study was performed in 10 primary care centres and 2 hospitals (june 2011-june 2014), including all otherwise healthy children ≥2 months ≤8 years with otitis media presentin ... | 2017 | 28146590 |
| antibiotic susceptibility and molecular analysis of invasive haemophilus influenzae in canada, 2007 to 2014. | previously we studied the antibiotic susceptibility of invasive haemophilus influenzae collected in canada from 1990 to 2006 and characterized isolates by serotype, mlst and ftsi gene sequencing for significant pbp3 mutations. | 2017 | 28137937 |
| from immunologically archaic to neoteric glycovaccines. | polysaccharides (ps) are present in the outermost surface of bacteria and readily come in contact with immune cells. they interact with specific antibodies, which in turn confer protection from infections. vaccines with ps from pneumococci, meningococci, haemophilus influenzae type b, and salmonella typhi may be protective, although with the important constraint of failing to generate permanent immunological memory. this limitation has in part been circumvented by conjugating glycovaccines to pr ... | 2017 | 28134792 |
| diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (copd) to non-typeable haemophilus influenzae. | exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (copd). both bacterial infections, such as those with non-typeable haemophilus influenzae (nthi), and exposures to diesel engine emissions are known to contribute to exacerbations in copd patients. however, the effect of diesel exhaust (de) exposure on the epithelial response to microbial stimulation is incompletely understood, and possible differences in the respons ... | 2017 | 28129777 |
| comparison of serotype prevalence of pneumococci isolated from middle ear, lower respiratory tract and invasive disease prior to vaccination in iceland. | information on pneumococcal serotype distribution before vaccination is a prerequisite for evaluation of vaccine effect. the aim was to investigate the prevalence of pneumococcal serotypes isolated from middle ear (me), lower respiratory tract (lrt) and from invasive disease (ipd) in iceland prior to implementation of ten-valent pneumococcal haemophilus influenzae protein d conjugate vaccine (phid-cv-10) into the infant vaccination program (april 2011). | 2017 | 28125588 |
| differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone. | acute otitis media (aom) causes an inflammatory response in the middle ear. we assessed differences in innate immune responses involved in bacterial defense at onset of aom in children who were stringently defined as otitis prone (sop) and children not otitis prone (nop). | 2016 | 28124644 |
| bacterial lysis through interference with peptidoglycan synthesis increases biofilm formation by nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults. a large variety of studies suggest that biofilm formation by nthi may be an important step in the pathogenesis of this bacterium. however, the underlying mechanisms involved in this process are poorly elucidated. in this study, we used a transposon mutant library to identify bacteri ... | 2017 | 28124027 |
| pediatric endogenous haemophilus influenzae endophthalmitis with presumed hyposplenism. | endogenous bacterial endophthalmitis is a rare but potentially devastating intraocular infection that can have severe sight-threatening complications. most patients with endogenous bacterial endophthalmitis have underlying infectious conditions, such as diabetes or malignancy, which predispose them to infection. | 2017 | 28115875 |
| temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease. | host surface receptors provide bacteria with a foothold from which to attach, colonize and in some cases, invade tissue and elicit human disease. in this review, we discuss several key host receptors and cognate adhesins that function in bacterial pathogenesis. in particular, we examine the elevated expression of host surface receptors such as ceacam-1, ceacam-6, icam-1 and pafr in response to specific stimuli. we explore how upregulated receptors, in turn, expose the host to a range of bacteria ... | 2017 | 28113047 |
| prospective evaluation of the aetiology of acute otitis media with spontaneous tympanic membrane perforation. | to evaluate the aetiological role of the main bacterial pathogens associated with acute otitis media (aom) in children with aom and spontaneous tympanic membrane perforation (stmp). | 2017 | 28110050 |
| first complete genome sequence of haemophilus influenzae serotype a. | haemophilus influenzae is an important human pathogen that primarily infects small children. in recent years, h. influenzae serotype a has emerged as a significant cause of invasive disease among indigenous populations. here, we present the first complete whole-genome sequence of h. influenzae serotype a. | 2017 | 28104664 |
| the national swedish immunisation programme includes vaccine against diphtheria, tetanus, polio, pertussis, haemophilus influenzae type b, pneumococcus as well as measles, mumps and rubella. data were collected on hospital admissions for children 0- 17 years of age of vaccine-preventable diseases during 2008-2013 at astrid lindgren children's hospital, stockholm. patients were identified by discharge diagnosis codes as well as from the clinical microbiology laboratory. there were rare cases of m ... | 2017 | 28094831 | |
| microbiology of otitis media in indigenous australian children: review. | to review research addressing the polymicrobial aetiology of otitis media in indigenous australian children in order to identify research gaps and inform best practice in effective prevention strategies and therapeutic interventions. | 2017 | 28088924 |
| budget impact analysis of vaccination against haemophilus influenzae type b as a part of a pentavalent vaccine in the childhood immunization schedule of iran. | health decision makers need to know the impact of the development of a new intervention on the public health and health care costs so that they can plan for economic and financial objectives. the aim of this study was to determine the budget impact of adding haemophilus influenzae type b (hib) as a part of a pentavalent vaccine (hib-hbv-dtp) to the national childhood immunization schedule of iran. | 2017 | 28088246 |
| vaccine candidates against nontypeable haemophilus influenzae: a review | nonencapsulated, nontypeable hemophilus influenzae (nthi) remains an important cause of acute otitis and respiratory diseases in children and adults. nthi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. the bacteria can also cause chronic diseases such as chronic bronchitis and chronic obstructive pulmonary disease in the lower respiratory trac ... | 2017 | 28088130 |
| aqueous humor antimicrobial activity: in vitro analysis after topical 0.5% chloramphenicol application. | to assess aqueous humor antimicrobial activity in vitro after topical 0.5% chloramphenicol application. | 2017 | 28085501 |
| vaccination with 10-valent pneumococcal conjugate vaccine in infants according to hiv status. | phase iii, open-label, single-center, controlled study in south africa (clinicaltrials.gov: nct00829010) to evaluate immunogenicity, reactogenicity, and safety of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) in human immunodeficiency virus (hiv)-infected (hiv+), hiv-exposed-uninfected (heu), and hiv-unexposed-uninfected (huu) children. | 2017 | 28079828 |
| evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. | the aim of this study is to compare the diagnostic performance of the line probe assay (lpa) with conventional multiplex polymerase chain reaction (pcr) for streptococcus pneumoniae as well as real-time pcr for neisseria meningitidis and haemophilus influenzae type b (hib) in cerebrospinal fluid (csf) samples from children during the multicenter national surveillance of bacterial meningitis between the years 2006 and 2009 in turkey. | 2017 | 28077083 |
| nasopharyngeal carriage of respiratory pathogens in warao amerindians: significant relationship with stunting. | to assess risk factors for nasopharyngeal carriage of potential pathogens in geographically isolated warao amerindians in venezuela. | 2017 | 28072501 |
| immunogenicity and safety of a booster injection of dtap-ipv//hib (pentaxim®) administered concomitantly with tetravalent dengue vaccine in healthy toddlers aged 15 to 18 months in mexico: a randomized trial. | the live, attenuated, tetravalent dengue vaccine (cyd-tdv) is licensed in a number of dengue endemic countries for individuals ≥9 years old. before integration of any vaccine into childhood vaccination schedules, a lack of immune interference and acceptable safety when co-administered with other recommended vaccines should be demonstrated. | 2017 | 28067718 |
| production of recombinant rhomboid proteases. | rhomboid proteases are intramembrane enzymes that hydrolyze peptide bonds of transmembrane proteins in the lipid bilayer. they play a variety of roles in key biological events and are linked to several disease states. over the last decade a great deal of structural and functional knowledge has been generated on this fascinating class of proteases. both structural and kinetic analyses require milligram amounts of protein, which may be challenging for membrane proteins such as rhomboids. here, we ... | 2017 | 28065266 |
| response to effectiveness of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d-conjugated vaccine (phid-cv) against carriage and acute otitis media-a double-blind randomized clinical trial in finland. | 2017 | 28064237 | |
| the main rhinovirus respiratory tract adhesion site (icam-1) is upregulated in smokers and patients with chronic airflow limitation (cal). | icam-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable haemophilus influenzae, two major pathogens in copd. increased cell-surface expression of icam-1 in response to tobacco smoke exposure has been suggested. we have investigated epithelial icam-1 expression in both the large and small airways, and lung parenchyma in smoking-related chronic airflow limitation (cal) patients. | 2017 | 28056984 |
| cord blood acute phase reactants predict early onset neonatal sepsis in preterm infants. | early onset sepsis (eos) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. evaluation of acute phase reactant (apr) biomarkers in umbilical cord blood at birth may improve eos detection in preterm infants with intrauterine infection. | 2017 | 28045978 |
| haemophilus species as a urinary tract pathogen. | haemophilus species, as a urinary tract pathogen, is rarely encountered. routine urine culture pathogens are well documented to include enterobacteriaciae, enterococcus spp., staphylococcus spp., pseudomonas spp., and candida spp. pathogens encountered rarely in this context may include corynebacterium ureolyticus and nonfermenting gram negative bacilli. this case study involves the finding of haemophilus influenzae in a urine culture performed on a 4-year-old caucasian girl and haemophilus pari ... | 2017 | 28039378 |
| evaluation of the immunogenic property of nt h. influenzae protein d with neisseria meningitidis omv in balb/c. | identifying ideal non typeable haemophilus influenzae (nthi) vaccine candidates has not been easy due to extensive sequence and antigenic variation among gene products interacting with the immune system. protein d (pd) is a highly conserved 42 kda surface lipoprotein available in all h. influenzae, including nthi. | 2016 | 28036315 |
| dtap5-hb-ipv-hib vaccine (vaxelis(®)): a review of its use in primary and booster vaccination. | vaxelis(®) is a fully liquid, ready-to-use, hexavalent vaccine approved in the eu for primary and booster vaccination in infants and toddlers from the age of 6 weeks against diphtheria, tetanus, pertussis, hepatitis b, poliomyelitis, and invasive diseases caused by haemophilus influenzae type b (hib). it contains diphtheria and tetanus toxoids, five acellular pertussis antigens, recombinant hepatitis b virus surface antigen produced in the yeast, saccharomyces cerevisiae, inactivated poliovirus, ... | 2017 | 28035545 |
| population pharmacokinetics and pharmacodynamics of levofloxacin in acutely hospitalized older patients with various degrees of renal function. | a retrospective study was conducted in a large sample of acutely hospitalized older patients who underwent therapeutic drug monitoring during levofloxacin treatment. the aim was to assess the population pharmacokinetics (poppk) and pharmacodynamics of levofloxacin among older patients. poppk and monte carlo simulation were performed to define the permissible doses in older patients according to various degrees of renal function. classification and regression tree (cart) analysis was used to dete ... | 2017 | 28031199 |
| attitudes of swiss health care providers toward childhood immunizations. | infovac is a network providing information about immunization issues to health professionals. the aim of this study was to assess the attitude of infovac subscribers toward the current swiss immunization schedule, potential modifications, and current and hypothetical immunization practices regarding their own children. | 2017 | 28030524 |
| immunogenicity and safety of 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered to children with sickle cell disease between 8 weeks and 2 years of age: a phase iii, open, controlled study. | immunogenicity, safety and reactogenicity of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) were evaluated in children with sickle cell disease (scd), who are at increased risk for infections. | 2016 | 28030521 |
| use of a booster dose of capsular group c meningococcal glycoconjugate vaccine to demonstrate immunologic memory in children primed with one or two vaccine doses in infancy. | use of a polysaccharide vaccine challenge to demonstrate immunologic memory after priming with capsular group c meningococcal conjugate vaccines (mencc) risks induction of immunologic hyporesponsiveness. for this reason, mencc vaccines are now used as probes of immunologic memory, however, no studies have demonstrated their ability to distinguish primed from unprimed children. | 2016 | 28029540 |
| haemophilus influenzae serotype f epiglottitis: a case report and review. | 2017 | 28028010 | |
| biochemical characterization of tyra enzymes from ignicoccus hospitalis and haemophilus influenzae: a comparative study of the bifunctional and monofunctional dehydrogenase forms. | biosynthesis of l-tyrosine (l-tyr) is directed by the interplay of two enzymes. chorismate mutase (cm) catalyzes the rearrangement of chorismate to prephenate, which is then converted to hydroxyphenylpyruvate by prephenate dehydrogenase (pd). this work reports the first characterization of the independently expressed pd domain of bifunctional cm-pd from the crenarchaeon ignicoccus hospitalis and the first functional studies of both full-length cm-pd and the pd domain from the bacterium haemophil ... | 2017 | 28025081 |
| recent epidemiology of streptococcus pneumoniae in nasopharynxes of korean children with acute otitis media. | this prospective study was performed to evaluate serotype distribution, multilocus sequence typing, and antibiotic susceptibility of streptococcus pneumoniae identified in korean children with acute otitis media (aom) after the introduction of a 7-valent pneumococcal conjugate vaccine (pcv7). | 2017 | 28024738 |
| real-time qpcr improves meningitis pathogen detection in invasive bacterial-vaccine preventable disease surveillance in fiji. | as part of the world health organization invasive bacterial-vaccine preventable diseases (ib-vpd) surveillance in suva, fiji, cerebrospinal fluid (csf) samples from suspected meningitis patients of all ages were examined by traditional methods (culture, gram stain, and latex agglutination for bacterial antigen) and qpcr for streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae. of 266 samples tested, pathogens were identified in 47 (17.7%). s. pneumoniae was the most commo ... | 2016 | 28009001 |
| antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable haemophilus influenzae. | in autoimmune diseases, there have been proposals that exogenous "molecular triggers", i.e., specific this should be 'non-self antigens' accompanying infectious agents, might disrupt control of the adaptive immune system resulting in serious pathologies. the etiology of the multiple sclerosis (ms) remains unclear. however, epidemiologic data suggest that exposure to infectious agents may be associated with increased ms risk and progression may be linked to exogenous, bacterially-derived, antigen ... | 2016 | 28008952 |
| emergence and molecular characterization of haemophilus influenzae harbouring mef(a). | 2017 | 27999037 | |
| microbiological features of upper respiratory tract infections in bulgarian children for the period 1998-2014. | across the globe, upper respiratory tract infections (urtis) are the most prevalent cause of morbidity in childhood. | 2016 | 27994923 |
| pneumonia prevention: cost-effectiveness analyses of two vaccines among refugee children aged under two years, haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, yida camp, south sudan. | by september 2013, war between sudan and south sudan resulted in >70,000 sudanese refugees and high pneumonia incidence among the 20,000 refugees in yida camp, south sudan. using médecins sans frontières (msf)-provided data and modifying our decision-tree models, we estimated if administering haemophilus influenzae type b (hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [dpt] and hepatitis b) and pneumococcal conjugate (pcv) vaccines were cost-effective against h ... | 2017 | 27989625 |