Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| a cloudy bag and genital ulcers. | a 30-year-old patient treated with ccpd presented with genital ulcers and a culture-negative peritonitis. herpes simplex virus type 2 (hsv-2) was cultured from the effluent and the genital lesions. primary hsv-2 infection was diagnosed by serology. this is the first documented case of pd peritonitis caused by hsv-2. we speculate that cases of culture-negative pd peritonitis may be due to recurrences of genital herpes. | 2006 | 16724662 |
| atypical cutaneous manifestation of hsv-2 with candida albicans co-infection in a patient with hiv-1. | herpes simplex virus type 2 (hsv-2) infection was one of the first opportunistic infections identified among patients with aids. in the literature there are many data suggesting that the natural history of hsv-2 infection is altered in hiv-hsv-2 co-infected patients. furthermore, a relationship between hiv seropositivity and hbv infection because of their analogous way of transmission is also described. we report the case of a 37-year-old patient who suffered from multiple painful ulcerative les ... | 2007 | 16716405 |
| disseminated herpes virus (hsv-2) infection with rhabdomyolysis and hemophagocytic lymphohistiocytosis in a patient with bone marrow failure syndrome. | 2006 | 16715456 | |
| synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity. | the discovery of new non-nucleoside antiviral compounds is of significant and growing interest for treating herpes virus infections due to the emergence of nucleoside-resistant strains. using a whole cell virus-induced cytopathogenic assay, we tested a series of substituted triaryl heterocyclic compounds including acridones, xanthones, and acridines. the compounds which showed activity against herpes simplex-1 and/or herpes simplex-2 were further assayed for inhibition of topoisomerase activity ... | 2006 | 16713270 |
| minimal change in hsv-2 seroreactivity: a cross-sectional swedish population study. | the prevalence of antibodies to herpes simplex virus type 2 (hsv-2) was determined in sera collected from 2 swedish cross-sectional populations during 1990/91 and 1996/97. a glycoprotein g2 (gg-2) peptide elisa was used to analyse 2899 sera from adults. we found a prevalence of 13.0% in 18-70-y-olds in 1990/91 and 16.4% in 31-55-y-olds in 1996/97. seropositivity to hsv-2 was somewhat higher in women than in men; 14.4% compared to 11.6% in 1990/91 and 18.9% compared to 13.6% in 1996/97. overall t ... | 2006 | 16709538 |
| effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus. | pancreatic cancer is a devastating disease that is almost universally fatal because of the lack of effective treatments. we recently constructed a novel oncolytic virus (fuson-h2) from the type 2 herpes simplex virus. because the replication potential of fuson-h2 depends on the activation of the ras signaling pathway, we evaluated its antitumor effect against pancreatic cancer, which often harbors k-ras gene mutations. | 2006 | 16707615 |
| diversity of the cd8+ t-cell response to herpes simplex virus type 2 proteins among persons with genital herpes. | cytolytic t cells play a major role in controlling herpes simplex virus type 2 (hsv-2) infections in humans. in an effort to more thoroughly evaluate the response to hsv-2 directly, ex vivo, we developed an enzyme-linked immunospot (elispot) assay that utilized pools of overlapping synthetic peptides presented by autologous dendritic cells to purified cd8(+) t cells. donor response rates to individual open reading frames (orfs) ranged from fewer than 5% responding to as many as 70% responding, w ... | 2006 | 16699031 |
| prediction and identification of herpes simplex virus 1-encoded micrornas. | micrornas (mirnas) are key regulators of gene expression in higher eukaryotes. recently, mirnas have been identified from viruses with double-stranded dna genomes. to attempt to identify mirnas encoded by herpes simplex virus 1 (hsv-1), we applied a computational method to screen the complete genome of hsv-1 for sequences that adopt an extended stem-loop structure and display a pattern of nucleotide divergence characteristic of known mirnas. using this method, we identified 11 hsv-1 genomic loci ... | 2006 | 16699030 |
| mucosal administration of cpg oligodeoxynucleotide elicits strong cc and cxc chemokine responses in the vagina and serves as a potent th1-tilting adjuvant for recombinant gd2 protein vaccination against genital herpes. | although sexually transmitted pathogens are capable of inducing pathogen-specific immune responses, vaginal administration of nonreplicating antigens elicits only weak, nondisseminating immune responses. the present study was undertaken to examine the potential of cpg-containing oligodeoxynucleotide (cpg odn) for induction of chemokine responses in the genital tract mucosa and also as a vaginal adjuvant in combination with glycoprotein d of herpes simplex virus type 2 (hsv-2) for induction of an ... | 2006 | 16699008 |
| evaluation of the cepheid herpes simplex virus typing real-time pcr assay using dermal and genital specimens. | the cepheid herpes simplex virus (hsv) (cepheid, sunnyvale, ca) typing multiplex real-time polymerase chain reaction (pcr) assay was evaluated for its ability to detect hsv in dermal and genital specimens stored in m5 media. swab specimens (n = 114) for hsv testing were placed in m5 media and split between our laboratory and a highly experienced reference laboratory. aliquots for testing with the cepheid assay were processed using a simple boil-and-go procedure and then run in a smartcycler ii ( ... | 2006 | 16698214 |
| the associations between pelvic inflammatory disease, trichomonas vaginalis infection, and positive herpes simplex virus type 2 serology. | roles for chlamydia trachomatis and neisseria gonorrhoeae infections in pelvic inflammatory disease pathogenesis are well delineated; however, the etiologic contributions of herpes simplex virus type 2 (hsv-2) and trichomonas vaginalis have been underexplored. | 2006 | 16691155 |
| risk factors for htlv-ii infection in peruvian men who have sex with men. | human t-cell lymphotropic virus type-ii (htlv-ii) infection is endemic in indigenous groups in the americas and injection drug users (idus) worldwide. in peru, htlv-ii infection was previously identified in two indigenous amazonians. we examined risk factors for htlv-ii infection in 2,703 peruvian men who have sex with men (msm): 35 (1.3%) were htlv-ii positive. htlv-ii infection was associated with syphilis, hsv-2 infection, unprotected receptive anal intercourse, and older age. this is the fir ... | 2006 | 16687704 |
| clinical correlates of index values in the focus herpeselect elisa for antibodies to herpes simplex virus type 2 (hsv-2). | clinical correlates of herpeselect elisa index values are poorly understood. | 2006 | 16677855 |
| prevention of the interaction between hvem, herpes virus entry mediator, and gd, hsv envelope protein, by a keggin polyoxotungstate, pm-19. | one of the keggin-type heteropolyoxotungstates (k7[pti2w10o40]6h2o:pm-19) is a potent inhibitor of the replication of herpes simplex virus (hsv) both standard strain 169 and the thymidine kinase-defective strain ys-4c-1 in vitro and in vivo. hsv envelope protein, gd, is necessary for virus entry into the cells. some cellular molecules, such as hvem, were reported to act as cofactors during the viral entry step. we determined whether pm-19 prevents these interactions between hsv-gd and hvem. thes ... | 2006 | 16675194 |
| clinical inquiries. what is the role of herpes virus serology in sexually transmitted disease screening? | 2006 | 16670044 | |
| prevalence of hiv in the us household population: the national health and nutrition examination surveys, 1988 to 2002. | to examine trends in hiv prevalence in the us household population, serum or urine samples from 2 national health and nutrition examinations surveys (nhanes) (1988-1994 and 1999-2002), were tested for hiv antibody. in the 1999 to 2002 survey, data on risk behaviors, cd4 t lymphocytes, and antiretroviral therapy (art) were also available. in the 1988 to 1994 survey, there were 59 positive individuals of 11,203 tested. in nhanes 1999 to 2002, there were 32 positive individuals of 5926 tested. the ... | 2006 | 16652040 |
| importance of herpes simplex virus type-1 (hsv-1) in primary genital herpes. | herpes simplex virus type 1 (hsv-1) is increasingly reported in primary genital herpes. its incidence was assessed among rotterdam sexually transmitted diseases clinic attendees between 1996 and 2001, and demographic and sexual behaviour factors were evaluated. a retrospective record analysis was performed. all herpes diagnoses were based on cell culture techniques. a clinical scoring system was used to select "primary" cases. demographic and sexual behaviour characteristics were analysed using ... | 2006 | 16648915 |
| diagnostics for herpes simplex virus: is pcr the new gold standard? | herpes simplex virus (hsv) is one of the most common, yet frequently overlooked, sexually transmitted infections. since the type of hsv infection affects prognosis and subsequent counseling, type-specific testing to distinguish hsv-1 from hsv-2 is recommended. although pcr has been the diagnostic standard for hsv infections of the central nervous system, until now viral culture has been the test of choice for hsv genital infection. however, hsv pcr, with its consistently and substantially higher ... | 2006 | 16646574 |
| burden of infection and insulin resistance in healthy middle-aged men. | we hypothesized that burden of infection could be associated with chronic low-grade inflammation, resulting in insulin resistance. we aimed to study the effect of exposure to four infections on insulin sensitivity in apparently healthy middle-aged men (n = 124). | 2006 | 16644637 |
| diagnosis of herpetic cervicitis and concurrent sexually transmitted infections in primary genital herpes. | 2006 | 16643690 | |
| prevalence of sexually transmitted infections among long-distance truck drivers in tongling, china. | little is known about sexually transmitted infections (stis), including hiv, among truck drivers in china. a cross-sectional study was conducted among truck drivers in tongling of anhui province. a total of 550 truck drivers were interviewed with a structured questionnaire, and blood samples were collected and tested for hiv, syphilis, and herpes simplex virus 2 (hsv-2), and urine specimens for neisseria gonorrhoeae and chlamydia trachomatis. prevalence was 10.6% for c. trachomatis and 8.1% for ... | 2006 | 16643679 |
| performance of a novel test for igm and igg antibodies in subjects with culture-documented genital herpes simplex virus-1 or -2 infection. | novel tests (bioplex) for herpes simplex virus-1 (hsv-1) and hsv-2 igg were compared with herpeselect hsv-1 and hsv-2 elisas for type-specific igg. the sensitivity and specificity of bioplex hsv-1 igg were 94% (84/89) and 96% (119/124), respectively, with unselected sera, while the sensitivity and specificity of bioplex hsv-2 igg were 92% (109/118) and 98% (95/97), respectively. bioplex igm was compared with diamedix igm against sera from patients with culture-documented genital herpes. the test ... | 2006 | 16643524 |
| dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands. | the methanol extract of ophirrhiza nicobarica, alstonia macrophylla and mallotus peltatus, ethnomedicines of little andaman, were investigated for antiinfective, antiinflammatory and antioxidant activities. | 2006 | 16636538 |
| cathelicidin deficiency predisposes to eczema herpeticum. | the cathelicidin family of antimicrobial peptides is an integral component of the innate immune response that exhibits activity against bacterial, fungal, and viral pathogens. eczema herpeticum (adeh) develops in a subset of patients with atopic dermatitis (ad) because of disseminated infection with herpes simplex virus (hsv). | 2006 | 16630942 |
| synthesis and antiviral evaluation of novel open-chain analogues of neplanocin a. | novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin a. the coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. the synthesized compounds ia-ii were evaluated for their antiviral activity against various viruses such as hiv hsv-1, hsv-2, and ecmv. | 2006 | 16629127 |
| trial shows hsv-2 suppression can reduce hiv shedding. | 2006 | 16628770 | |
| catastrophic acute retinal necrosis syndrome associated with diffuse orbital cellulitis: a case report. | to report a case of severe acute retinal necrosis syndrome (arn) associated with initial features of orbital cellulitis. | 2007 | 16628421 |
| herpes incognito most commonly is herpes zoster and its histopathologic pattern is distinctive! | infections of the skin by herpesviruses do not always present themselves in typical fashion. conventional microscopy is used routinely to confirm infection by herpesviruses, but sometimes typical signs such as multinucleated epithelial cells or "ghosts" of them are not encountered in a specimen (so-called herpes incognito). we studied 35 patients in whom infection with herpesviruses was differentially diagnosed clinically but in whom a biopsy specimen had been taken for confirmation. only those ... | 2006 | 16625086 |
| [morphological changes of ecv304 cells infected by herpes simplex virus type 2]. | to observe the pathological changes and morphological alterations of ecv304 cells after the infection by herpes simplex virus type 2 (hsv-2) in vitro. | 2006 | 16624748 |
| increase of genital hsv-1 and mixed hsv-1 and hsv-2 infection in bangkok, thailand. | from january 1998 to december 2004, 207 out of 1125 samples were hsv isolation positive and typed. two groups of patients, thai and foreigner, as well as site of infection, non-genital and genital area, were identified. the prevalence of non-genital hsv-1 infection from 27 samples of thai patients was 81.84%. out of 180 genital samples, 39.02% hsv-1 and 43.09% hsv-2 from 123 thai patients and 36.84% hsv-1 and 49.12% hsv-2 of 57 foreigner patients were determined. moreover mixed infection of hsv- ... | 2005 | 16623045 |
| antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses. | a series of 42 lipophilic bromovinyldeoxyuridine monophosphates (bvdumps) are presented as potential prodrugs of the antiviral agent (e)-5-(2-bromovinyl)-2'-deoxyuridine (bvdu). the 5'-cyclosal-masking group technique has been applied to this cyclic nucleoside analogue to achieve delivery of the monophosphate of bvdu inside the target cells. the new substances have been tested for their antiviral activity against herpes simplex virus types 1 and 2 (hsv-1 and -2), thymidine kinase-deficient (tk(- ... | 2006 | 16621459 |
| potent protective cellular immune responses generated by a dna vaccine encoding hsv-2 icp27 and the e. coli heat labile enterotoxin. | a mouse model was employed to evaluate protective cellular immune responses induced by an immediate early antigen of hsv-2. particle-mediated dna vaccination of mice with a dna plasmid-encoding icp27 resulted in the induction of icp27-specific ifn-gamma and tnf-alpha production in balb/c mice, but little protection to intranasal challenge with wild type hsv-2. however, when the dna vaccine was supplemented with as little as 50ng of a vector encoding the a and b subunits of the escherichia coli h ... | 2006 | 16621198 |
| ribonucleotide reductase inhibitors as anti-herpes agents. | ribonucleotide reductases (rnrs) supply the 2'-deoxyribonucleotide building blocks for dna synthesis in mammalian cells and for herpes viruses. the viral-encoded rnrs have unique protein sequences that differ from mammalian enzyme primary structures. selective inhibition of a viral rnr might provide an approach to new anti-herpes agents with minimal effects on the mammalian host rnrs. this review summarizes efforts to develop anti-herpes agents that selectively target viral-encoded rnrs. | 2006 | 16621038 |
| [treatment of neonatal herpes]. | 2006 | 16615488 | |
| [meningitis]. | 2006 | 16615482 | |
| [neonatal herpes]. | 2006 | 16615481 | |
| [herpes encephalitis]. | 2006 | 16615480 | |
| [acute retinal necrosis due to herpesviridae infections]. | 2006 | 16615476 | |
| [serodiagnosis for alphaherpesvirinae infections]. | 2006 | 16615474 | |
| [diagnosis of hsv-1, hsv-2 infection]. | 2006 | 16615472 | |
| [epidemiology of genital herpes]. | 2006 | 16615470 | |
| [trends in antibody prevalence of herpes simplex virus types 1 and 2]. | 2006 | 16615468 | |
| multifactorial etiology of cervical cancer: a hypothesis. | cancer of the cervix is the second most common life-threatening cancer among women worldwide, with incidence rates ranging from 4.8 per 100,000 women per year in the middle east to 44.3 per 100,000 in east africa. epidemiologic and clinical data demonstrate that human papillomaviruses (hpv), especially hpv-16 and hpv-18, play at least a major if not a necessary role in the etiology of cervical cancer. however, many investigators acknowledge that hpv is not sufficient to induce cervical cancer an ... | 2005 | 16614679 |
| decline in the prevalence of antibodies to herpes simplex virus types 1 and 2 among israeli young adults between 1984 and 2002. | the objective of this study was to estimate the seroprevalence of herpes simplex virus (hsv) types 1 and 2 in male and female soldiers discharged from the israel defense force (idf) over a period of 18 years. | 2006 | 16614586 |
| lambda interferon (ifn-lambda), a type iii ifn, is induced by viruses and ifns and displays potent antiviral activity against select virus infections in vivo. | type iii interferons (ifns) (interleukin-28/29 or lambda interferon [ifn-lambda]) are cytokines with ifn-like activities. here we show that several classes of viruses induce expression of ifn-lambda1 and -lambda2/3 in similar patterns. the ifn-lambdas were-unlike alpha/beta interferon (ifn-alpha/beta)-induced directly by stimulation with ifn-alpha or -lambda, thus identifying type iii ifns as ifn-stimulated genes. in vitro assays revealed that ifn-lambdas have appreciable antiviral activity agai ... | 2006 | 16611910 |
| recombinant vesicular stomatitis virus vectors expressing herpes simplex virus type 2 gd elicit robust cd4+ th1 immune responses and are protective in mouse and guinea pig models of vaginal challenge. | recombinant vesicular stomatitis virus (rvsv) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. we evaluated rvsv vectors expressing full-length glycoprotein d (gd) from herpes simplex virus type 2 (hsv-2) in mice and guinea pigs for immunogenicity and protective efficacy against genital challenge with wild-type hsv-2. robust th1-polarized anti-gd immune responses were demonstrated in the murine ... | 2006 | 16611905 |
| genital herpes vaccines--cause for cautious optimism. | the high prevalence of herpes simplex virus infections in many communities, its numerous serious physical and psychological complications and its importance in enhancing the transmission of hiv make this virus an obvious target for prevention by vaccination. randomised clinical trials of only one genital herpes vaccine has shown efficacy so far. analysis of clinical results is complicated by the difference between disease and infection, different results for males and females and the interaction ... | 2006 | 16607967 |
| association of two membrane proteins encoded by herpes simplex virus type 2, ul11 and ul56. | herpes simplex virus (hsv) acquires envelope by budding into trans-golgi network (tgn)-derived vesicles. previous studies showed that the ul11 gene product enables efficient virion envelopment and export from infected cells and is incorporated into virions as tegument protein. at its n-terminus, ul11 is dually acylated by myristoic and palmitoic acids. fatty acylation of ul11 provides both membrane binding strength and golgi-targeting specificity. we show here that ul11 interacts with ul56 prote ... | 2006 | 16604447 |
| mesenchymal stem cells are susceptible to human herpesviruses, but viral dna cannot be detected in the healthy seropositive individual. | allogeneic stem cell transplantation is often complicated by reactivation of herpesviruses. mesenchymal stem cells (msc) are immunomodulatory and may be used to treat graft-versus-host disease. we investigated if herpesviruses infect and can be transmitted by msc, and if msc suppress immune responses to various infectious agents. mesenchymal stem cells from healthy seropositive donors were evaluated with polymerase chain reaction for the most common herpesviruses: cytomegalovirus (cmv), herpes s ... | 2006 | 16604097 |
| herpes simplex virus infection in women in the wihs: epidemiology and effect of antiretroviral therapy on clinical manifestations. | to determine the prevalence of infection with herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) among women with and at high risk for hiv infection, and to evaluate the effect of haart on the recurrence of genital lesions. | 2006 | 16603858 |
| herpes virus type 2 infection and genital symptoms in primary care patients. | we aimed to identify whether genital symptoms were associated with unrecognized herpes simplex virus type 2 (hsv-2) infection in a primary care population. | 2006 | 16601657 |
| expression of entry receptor nectin-1 of herpes simplex virus 1 and/or herpes simplex virus 2 in normal and neoplastic human nervous system tissues. | herpes simplex virus 1 and/or herpes simplex virus 2 (hsv) are important pathogens of human nervous system (ns) and genetically modified hsv strains have been proposed as vectors for gene therapy targeting the brain and brain tumors. nectin-1 is an immunoglobulin-like adhesion molecule that participates in the formation of synapses and serves as an entry receptor for hsv. the expression pattern of nectin-1 in normal human ns and brain tumors is not well understood. to better understand the necti ... | 2006 | 16599187 |
| prevalence and incidence of, and risk factors for, hiv-1 infection among factory workers in ethiopia, 1997-2001. | the study was conducted to determine the prevalence, incidence, and risk factors for hiv infection among factory workers at two sites in ethiopia. during february 1997-december 2001, a structured questionnaire was used for obtaining information on sociodemographics, sexual behaviour, and reported sexually transmitted infections (stis) from a cohort of 1679 individuals. serum samples were screened for antibodies against hiv, treponema pallidum haemaglutination (tpha), and herpes simplex virus typ ... | 2005 | 16599107 |
| fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman. | we report an immunocompetent woman with multisystem organ failure following herpes simplex virus type 2 (hsv-2) hepatitis. after she initially responded to intravenous acyclovir, she was switched to oral valacyclovir. she developed respiratory failure and opportunistic infections and died. autopsy confirmed disseminated hsv infection, and lung tissue grew acyclovir-resistant hsv-2. | 2006 | 16597901 |
| synthesis of non-nucleosides: 7- and 1,3-substituents of new pyrrolo[2,3-d]pyrimidin-4-ones on antiviral activity. | a series of non-nucleosides 9-47 were synthesized. compounds 1-4 were reacted with formic acid (85%) to afford compounds 5-8. then, the latter compounds were reacted with alkyl halides a-f (2-bromopropane, 2-bromobutane, benzyl bromide, benzyl chloromethyl ether, chloromethyl ethyl ether, phenacyl bromide) in the presence of nah in dry dmf to give the desired compounds 9-47, which were evaluated for activity against herpes simplex virus type-ii (hsv-ii). | 2006 | 16586425 |
| chlamydia psittaci is variably associated with ocular adnexal malt lymphoma in different geographical regions. | infectious agents play a critical role in malt lymphoma development. studies from italy showed chlamydia psittaci infection in 87% of ocular adnexal malt lymphomas and complete or partial regression of the lymphoma after c. psittaci eradication in four of nine cases. however, c. psittaci was not demonstrated in ocular adnexal malt lymphomas from the usa. this study was thus designed to investigate further the role of c. psittaci, and other infectious agents commonly associated with chronic eye d ... | 2006 | 16583361 |
| the first immunoglobulin-like domain of porcine nectin-1 is sufficient to confer resistance to pseudorabies virus infection in transgenic mice. | nectin-1 is an alphaherpesvirus receptor that binds to virion glycoprotein d (gd). porcine nectin-1 mediates entry of pseudorabies virus (prv), herpes simplex virus types 1 and 2 (hsv-1 and hsv-2), and bovine herpesvirus type 1 (bhv-1). the gd-binding domain of nectin-1 is the first or n-terminal immunoglobulin (ig)-like domain of the entire ectodomain. here, we generated three transgenic mouse lines expressing a fusion protein consisting of the first ig-like domain of porcine nectin-1 and the f ... | 2006 | 16583156 |
| prevalence of infection with herpes simplex virus types 1 and 2 in australia: a nationwide population based survey. | studies demonstrating previous herpes simplex virus (hsv) type 2 infection as a risk factor for hiv transmission, and the development of a hsv vaccine candidate, have emphasised the need for worldwide population based studies of hsv seroprevalence. the only nationwide seroprevalence studies have been conducted in the united states. | 2006 | 16581748 |
| type specific seroprevalence of hsv-1 and hsv-2 in four geographical regions of poland. | to examine the type specific seroprevalence of herpes simplex virus (hsv) types 1 and 2 infections, stratified by age and gender, and associated risk factors for hsv-2 seropositivity in poland. | 2006 | 16581747 |
| the psychosocial impact of serological diagnosis of asymptomatic herpes simplex virus type 2 infection. | to evaluate the impact of a positive herpes simplex virus type 2 (hsv-2) serological test on psychosocial functioning among people with no known history of genital herpes. | 2006 | 16581745 |
| male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. | male circumcision is associated with reduced risk of hiv infection. this may be partly because of a protective effect of circumcision on other sexually transmitted infections (sti), especially those causing genital ulcers, but evidence for such protection is unclear. our objective was to conduct a systematic review and meta-analyses of the associations between male circumcision and infection with herpes simplex virus type 2 (hsv-2), treponema pallidum, or haemophilus ducreyi. | 2006 | 16581731 |
| herpes simplex virus type 1 and 2 glycoprotein c prevents complement-mediated neutralization induced by natural immunoglobulin m antibody. | glycoprotein c (gc) of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) binds complement component c3b and protects virus from complement-mediated neutralization. differences in complement interacting domains exist between gc of hsv-1 (gc1) and hsv-2 (gc2), since the amino terminus of gc1 blocks complement c5 from binding to c3b, while gc2 fails to interfere with this activity. we previously reported that neutralization of hsv-1 gc-null virus by hsv antibody-negative human serum requires a ... | 2006 | 16571820 |
| identification of functional domains in herpes simplex virus 2 glycoprotein b. | glycoprotein b (gb) is one of four membrane proteins that are essential for the entry of herpes simplex viruses (hsv) into cells, and coexpression of the same combination of proteins in transfected cells results in cell fusion. the latter effect is reminiscent of the ability of virus infection to cause cell fusion, particularly since the degree of fusion is greatly increased by syncytial mutations in gb. despite intensive efforts with the gb homologs of hsv and some other herpesviruses, informat ... | 2006 | 16571796 |
| herpes simplex virus and the chemokines that mediate the inflammation. | herpes simplex viruses (hsv) are highly pervasive pathogens in the human host with a seroconversion rate upwards of 60% worldwide. hsv type 1 (hsv-1) is associated with the disease herpetic stromal keratitis, the leading cause of infectious corneal blindness in the industrialized world. individuals suffering from genital herpes associated with hsv type 2 (hsv-2) are found to be two- to threefold more susceptible in acquiring human immunodeficiency virus (hiv). the morbidity associated with these ... | 2006 | 16570856 |
| a mutant type 2 herpes simplex virus deleted for the protein kinase domain of the icp10 gene is a potent oncolytic virus. | replication-selective oncolytic herpes simplex virus (hsv) has shown considerable promise as an antitumor agent. although the current oncolytic hsvs were exclusively constructed from hsv-1, hsv-2 has several unique features that could be exploited to convert the virus to an oncolytic agent. the n-terminus of the hsv-2 icp10 gene product contains a well-defined serine/threonine protein kinase (pk) domain, which can activate the ras/mek/mapk mitogenic pathway and thus facilitate efficient hsv-2 re ... | 2006 | 16569513 |
| how safe is safer sex? high levels of hsv-1 and hsv-2 in female sex workers in london. | female sex workers in europe have low levels of sexually transmitted infections, attributable to condom use. the aim of this paper is to describe the seroepidemiology of hsv-1 and hsv-2 in female sex workers in london by using a 15-year prospective study of 453 sex workers. the seroprevalence of hsv-1 was 74.4% and independently associated with birth in a 'transitional country' (or 5.4, 95% ci 1.61-18.20). the seroprevalence of hsv-2 was 60% and declined over time; it was also independently asso ... | 2006 | 16569273 |
| chronic infections by herpes simplex viruses and by the horse and cat herpesviruses. | rabbit eyes experimentally infected with either type 1 or type 2 herpes simplex viruses occasionally released virus spontaneously. injection of adrenalin was not highly effective for stimulating virus release but did seem to have a slight and erratic activating capacity. no spontaneous virus release were detected from the eyes of six cats infected with cat herpesvirus, but, when adrenalin was administered, an episode of virus release did ensue in one animal. rabbit spinal cords could be chronica ... | 1970 | 16557741 |
| topical antiviral sirna: a practical sirna microbicide? | 2006 | 16554841 | |
| herpetic lesion mimicking lower eyelid malignancy. | this photo-essay illustrates a case of a rapidly enlarging and ulcerated lower eyelid lesion in an hiv-positive man that was thought to be a malignant lesion. the biopsy revealed inclusions consistent with herpesvirus. this clinical entity should be considered in the clinician's differential diagnosis of eyelid lesions. | 2006 | 16550068 |
| hiv, syphilis, herpes simplex virus 2, and behavioral surveillance among conflict-affected populations in yei and rumbek, southern sudan. | little is known about the hiv epidemic in conflict-affected southern sudan. during 2002-2003, we conducted behavioral and biological surveillance surveys and sequential sampling in antenatal clinics in yei, western equatoria, and rumbek, bar-el-ghazal. hiv prevalence among individuals aged 15-49 years ranged between 0.4% in rumbek town and 4.4% in yei town, and among pregnant women between 0.8 and 3.0%, respectively. after the recent peace agreement, targeted prevention programmes are urgently n ... | 2006 | 16549984 |
| the effect of a methyl or 2-fluoroethyl substituent at the n-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-d-arabinosylthymine on their antiviral and cytostatic activity in cell culture. | thymidine (thd), 1-beta-d-arabinosylthymine (ara-t) and 3'-fluoro-3'-deoxythymidine (flt) have been substituted at n-3 by a methyl or a 2-fluoroethyl group. flt and ara-t are markedly inhibitory against human immunodeficiency virus type 1 (hiv-1) and hiv-2, and herpes simplex virus type 1 (hsv-1) and hsv-2, respectively. modification at n-3 of these compounds markedly decreases both the antiviral and cytostatic activity of the parent compounds flt and ara-t except for n-3-(methyl)-thd that prove ... | 2006 | 16542002 |
| comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding. | daily antiviral therapy with famciclovir and valacyclovir has been shown to be effective in reducing both symptomatic and asymptomatic reactivation of herpes simplex virus type 2 (hsv-2) when compared to placebo. however, few comparative studies between the 2 antivirals have been performed. | 2006 | 16540883 |
| incidence and prevalence of herpes simplex virus infections in adolescent women. | we conducted this study to examine the incidence, prevalence, and risk factors for herpes simplex virus (hsv) 1 and hsv 2 infection in a cohort of young women who were closely followed for acquisition of sexually transmitted infections. | 2006 | 16540882 |
| neonatal herpes simplex virus infection presenting as acute liver failure: prevalent role of herpes simplex virus type i. | acute liver failure (alf) in neonates is rare but carries a high mortality without liver transplantation. herpes simplex virus (hsv) is one of the microbes that more commonly causes alf and is potentially treatable; hence, early diagnosis and treatment are important to avoid progression to liver failure. | 2006 | 16540797 |
| herpes folliculitis: clinical, histopathological, and molecular pathologic observations. | herpes folliculitis is a rare manifestation of herpes virus infection and it is often misdiagnosed. diagnostic criteria are not well established, only 24 patients being reported in the literature. recently it has been suggested that herpetic folliculitis is more common in infections with varicella zoster (vzv) than in those with herpes simplex viruses (hsv-1 and -2). | 2006 | 16536821 |
| anatomical mapping of human herpesvirus reservoirs of infection. | following primary infection, all eight human herpesviruses persist lifelong in the human host. however, a mapping of all anatomic sites of human herpesvirus persistence is lacking. fresh tissue specimens representing approximately 40 major anatomic sites from eight autopsies were screened using a recently developed real-time pcr method for detection of all eight human herpesviruses. patients with evidence of active herpesvirus infection (herpes simplex 1 (hsv-1), herpes simplex 2 (hsv-2), varice ... | 2006 | 16528368 |
| valacyclovir therapy to reduce recurrent genital herpes in pregnant women. | the purpose of this study was to estimate the efficacy of valacyclovir suppressive therapy in pregnant women with recurrent genital herpes. | 2006 | 16522412 |
| the spectrum of genital herpes simplex virus infection in men attending a sexually transmitted disease clinic. | the spectrum of genital herpes (gh) has been understudied in men, especially african american men. | 2006 | 16518750 |
| [herpes simplex virus type 1 and 2 (hsv-1,2) dna detection by pcr during genital herpes]. | the oligonucleotide primers for herpes simplex virus type 1 and 2 dna detection are developed. in examined group of patients with genital herpes the virus of type 2 and type 1 was detected in 63% and 26% cases, respectively. the mixed infection of both types is revealed in 11% of the patients. | 2006 | 16512611 |
| association of genital shedding of herpes simplex virus type 2 and hiv-1 among sex workers in rural zimbabwe. | herpes simplex virus type 2 (hsv-2) facilitates sexual acquisition of hiv-1 but data on transmission are less clear. in this study the interaction between genital shedding of hiv-1 and hsv-2 was explored among zimbabwean sex workers. | 2006 | 16511420 |
| silencing herpes simplex virus with a vaginal microbicide. | 2006 | 16510753 | |
| worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. | most cancers of the uterine cervix are squamous cell carcinomas. although the incidence of such carcinomas of the uterine cervix has declined over time, that of cervical adenocarcinoma has risen in recent years. the extent to which human papillomavirus (hpv) infection and cofactors may explain this differential trend is unclear. | 2006 | 16507827 |
| human immunodeficiency virus test-seeking motivation in blood donors, são paulo, brazil. | previous studies have shown that volunteer, community-recruited donors have a higher prevalence of human immunodeficiency virus (hiv) infection in são paulo, brazil, than replacement donors. one hypothesis which may explain this unexpected finding is that some individuals donate blood because they are seeking hiv testing. the objective of this study was to characterize test-seeking blood donors and to determine whether they are at higher risk for hiv infection compared with other donors. | 2006 | 16507016 |
| human immunodeficiency virus type 1 among bar and hotel workers in northern tanzania: the role of alcohol, sexual behavior, and herpes simplex virus type 2. | we assessed baseline prevalence of human immunodeficiency virus type 1 (hiv-1) and other stds, as well as behavioral and biologic risk factors for hiv-1 in a population of female bar/hotel workers in moshi, tanzania. | 2006 | 16505740 |
| the public health imperative for a neonatal herpes simplex virus infection surveillance system. | about 1 in 5 sexually active adults in the united states has serologic evidence of genital herpes caused by herpes simplex virus type-2. neonatal herpes simplex virus infection is a serious consequence of genital herpes infection. herpes infection in neonates causes significant morbidity and neurologic damage and generally has a case-fatality ratio untreated of 60%. it is estimated that 440 to 1,320 cases of neonatal herpes infections occur in the united states per year (11-33 cases occur per 10 ... | 2006 | 16505733 |
| innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory cd4+ lymphocytes. | herpes simplex virus (hsv) infections of humans are characterized by intermittent, lytic replication in epithelia. circulating hsv-specific cd4 t cells express lower levels of preformed cutaneous lymphocyte-associated antigen (cla), a skin-homing receptor, than do circulating hsv-specific cd8 t cells but, paradoxically, move into infected skin earlier than cd8 cells. memory cd4 t cells develop strong and selective expression of cla and e-selectin ligand while responding to hsv antigen in vitro. ... | 2006 | 16501095 |
| epitope mapping of herpes simplex virus type 2 gh/gl defines distinct antigenic sites, including some associated with biological function. | the gh/gl complex plays an essential role in virus entry and cell-cell spread of herpes simplex virus (hsv). very few immunologic reagents were previously available to either identify important functional regions or gain information about structural features of this complex. therefore, we generated and characterized a panel of 31 monoclonal antibodies (mabs) against hsv type 2 (hsv-2) gh/gl. fourteen mabs bound to a conformation-dependent epitope of the gh2/gl2 complex, and all blocked virus spr ... | 2006 | 16501070 |
| intranasal administration of the growth-compromised hsv-2 vector deltarr prevents kainate-induced seizures and neuronal loss in rats and mice. | identification of targets and delivery platforms for gene therapy of neurodegenerative disorders is a clinical challenge. we describe a novel paradigm in which the neuroprotective gene is the herpes simplex virus type 2 (hsv-2) antiapoptotic gene icp10pk and the vector is the growth-compromised hsv-2 mutant deltarr. deltarr is delivered intranasally. it is not toxic in rats and mice. icp10pk is expressed in the hippocampus of the deltarr-treated animals for at least 42 days in the absence of vir ... | 2006 | 16500153 |
| vaccines for herpes simplex virus infections. | infections with herpes simplex virus (hsv) type 1 (hsv-1) and type 2 (hsv-2) can have serious medical consequences. although antiviral medications can suppress symptomatic disease, asymptomatic shedding and transmission, they neither cure nor alter the natural history of hsv infections. manipulation of the immune response is one potential method to decrease disease burden. current research on prophylactic and therapeutic vaccination approaches is discussed in this review, with a focus on compoun ... | 2006 | 16499283 |
| [difficulties in early diagnosis of herpes simplex encephalitis]. | herpes simplex virus infection of the central nervous system is still a significant cause of morbidity and often mortality at relatively young people. changes of central nervous system are results of primary infection or activation of latent hsv-1, hsv-2. neurological deficits often follow encephalitis herpetica. ct, mri and spect are usefull tools in early recognition of herpes encephalitis. the aplication of pcr is prompt and specific diagnosis of herpes simplex virus infections of the brain. ... | 2005 | 16498820 |
| inactivation of herpes simplex virus clinical isolates by using a combination microbicide. | a combination microbicide using the lipid-ether 1-0-octyl-sn-glycerol (og) (3 mm) and peptide lsa5 (9 microm) synergistically inactivated six clinical isolates of herpes simplex virus type 2 (hsv-2) by 30- to 100-fold and five of six hsv-1 isolates by 10-fold more than the sum of og and lsa5 used individually within 30 min. og plus lsa5 inactivated all hsv clinical isolates by > or = 1,000-fold in 10 to 40 min. | 2006 | 16495269 |
| sexual behavior, condom use, and human papillomavirus: pooled analysis of the iarc human papillomavirus prevalence surveys. | human papillomavirus (hpv) is a sexually transmitted infection but it is unclear whether differences in transmission efficacy exist between individual hpv types. information on sexual behavior was collected from 11 areas in four continents among population-based, age-stratified random samples of women of ages > or = 15 years. hpv testing was done using pcr-based enzyme immunoassay. unconditional logistic regression was used to estimate odds ratios (or) of being hpv positive and corresponding 95% ... | 2006 | 16492924 |
| antiviral activity of a carrageenan from gigartina skottsbergii against intraperitoneal murine herpes simplex virus infection. | the partially cyclized mu/nu-carrageenan 1c3, isolated from the red seaweed gigartina skottsbergii, was previously shown to be a potent inhibitor of the in vitro replication of herpes simplex virus types 1 (hsv-1) and 2 (hsv-2). here the protective effect of 1c3 in a murine model of intraperitoneal ( i. p.) hsv-1 infection was evaluated. of1 mice were i. p. infected with 5 x 10 (5) pfu of hsv-1 kos strain, and the effects of different treatments with 1c3 were studied. when 30 mg/kg of body weigh ... | 2006 | 16491446 |
| ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy. | to review the changing epidemiology of herpes simplex virus infection, emerging patterns of herpetic ocular disease, and the challenges and promise of herpes simplex virus vaccine therapy. | 2006 | 16490506 |
| a tale of 2 alpha-herpesviruses: lessons for vaccinologists. | of the 8 known herpesviruses that affect human beings, we only have successful vaccines against varicella zoster virus. this brief review compares the pathogenesis of varicella zoster virus with that of the closely related alpha-herpesviruses herpes simplex virus 1 and 2, for which we have no satisfactory vaccines. the main objective of this review is to learn lessons from the success of varicella zoster virus vaccine that could be exploited for the development of successful vaccines against her ... | 2006 | 16477558 |
| cytotoxic herpes simplex type 2-specific, dq0602-restricted cd4 t+-cell clones show alloreactivity to dq0601. | alloreactivity is one of the most serious problems in organ transplantation. it has been hypothesized that pre-existing alloreactive t cells are actually cross-reacting cells that have been primed by the autologous major histocompatibility complex (mhc) and a specific peptide. cd8+ cytotoxic t lymphocytes that are alloreactive and recognize a virus-peptide that is presented by the autologous mhc have been reported. here we demonstrate a cross-reactivity that exists between dq0602 restricted, her ... | 2006 | 16476054 |
| fostering acceptance of human papillomavirus and herpes simplex virus vaccines among adolescents and parents. | vaccines for human papillomavirus and herpes simplex virus are currently in development, and these vaccines could be an effective and cost-effective strategy to control these diseases. young adolescents are likely to be the target recipients of these vaccines. these vaccines, however, will only be successful in reducing the prevalence of these diseases if accepted. this manuscript will focus on the issues associated with the acceptability of these vaccines by healthcare providers, parents, and a ... | 2006 | 16470163 |
| decline in sexually transmitted infection prevalence and hiv incidence in female barworkers attending prevention and care services in mbeya region, tanzania. | to assess trends in sexually transmitted infection (sti) prevalence and hiv incidence and associated factors in a cohort of female barworkers exposed to behavioural interventions and sti screening and treatment. | 2006 | 16470126 |
| prenatal infection as a risk factor for schizophrenia. | accumulating evidence suggests that prenatal exposure to infection contributes to the etiology of schizophrenia. this line of investigation has been advanced by birth cohort studies that utilize prospectively acquired data from serologic assays for infectious and immune biomarkers. these investigations have provided further support for this hypothesis and permitted the investigation of new infectious pathogens in relation to schizophrenia risk. prenatal infections that have been associated with ... | 2006 | 16469941 |
| genital shedding of herpes simplex virus type 2 in childbearing-aged and pregnant women living in gabon. | the prevalence of genital shedding of herpes simplex virus (hsv)-2 and related risk factors was evaluated in a prospective population of 355 women attending the maternity joséphine bongo, in libreville, gabon. we found a high prevalence (66%) of hsv-2 seropositivity, with a high proportion, 14%, of women harbouring hsv-2 dna shedding in their genital secretions. hsv-2 genital shedding was positively associated with previous episodes of genital blisters, current genital ulcer, current genital bli ... | 2006 | 16464276 |