Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [study of pulmonary t cell subsets and killer activity in lung cancer]. | studies were performed to determine natural killer (nk) activity (ability to lyse 51cr labeled k562 target cells) and t cell subsets (with okt3, okt4, or okt8 antigen detected by indirect immunofluorescence technique) both in bronchoalveolar lavage fluid (balf) and peripheral blood of 40 lung cancer patients with different pathological type and 39 healthy controls. our results showed that the percentage of total t cell (t3) and t suppressor cells in balf were elevated both in the tumour involved ... | 1990 | 1975773 |
| metamorphic rate as a function of the light/dark cycle in rana pipiens larvae. | 1. the rate of development of rana pipiens tadpoles in spontaneous and thyroxine (t4)-induced metamorphosis was studied on light/dark (ld) cycles in which the photophase was held constant while the scotophase was progressively extended or vice versa. 2. metamorphic rate fluctuated in both types of experiments as the ld cycle lengthened. however, the pattern of resonance differed with the length of the photophase. for example, with an 8 hr light phase, development rate slowed and then increased a ... | 1990 | 1975539 |
| assessment of local cellular immunity in lung cancer by bronchoalveolar lavage. | small cell lung cancer (sclc) is the most malignant of the pulmonary neoplasms and is associated with a poor local cellular immune response. 16 patients with non small cell lung cancer (nsclc) and 11 patients with sclc underwent bronchoalveolar lavage (bal) in the lung which harbored the tumor in order to investigate the lymphocyte surface antigens utilizing the immunoperoxidase technique. analysis of blood lymphocytes was performed in parallel. 8 patients with previous sarcoidosis in complete r ... | 1990 | 1975283 |
| [mononuclear cell subsets in the peripheral blood of patients with myasthenia gravis]. | with the use of the wuhan series of monoclonal anti-lymphocyte antibodies, the peripheral blood mononuclear cell subpopulations in 104 patients with myasthenia gravis were studied. before treatment, the mean t4/t8 ratio was higher and the percentage of wut8+ cells (suppressor t cells) was lower in patients than in the controls. furthermore, they also showed a higher number of b cells and abnormal lymphocytes (including immature thymocytes and tac cells) in the blood. in this series 50 cases afte ... | 1990 | 1975232 |
| 32p-postlabeling of 7-methylguanine adducts in dna. | the 32p-postlabeling technique introduced by randerath and co-workers has been particularly successful with stable and nonpolar dna adducts, but the assay has not been used to any large extent to detect 7-alkylguanine derivatives. in the present communication, we have investigated the phosphorylation reaction by t4 polynucleotide kinase using 7-methyl-3'-dgmp, ring-opened 7-methyl-3'-dgmp and enzyme-digested methylated dna as substrates. the methylated substrates were detected at femtomol (fmol) ... | 1990 | 1975126 |
| endocrine-nutrition interactions in birds. | this review will discuss the uses of avian models, particularly the chicken, to examine nutrition-endocrine interactions. the chicken has been employed extensively to examine nutritional effects. the effects of fasting, protein deficiency and calcium deficiency on endocrine status have been the subject of intense investigation in young chicks and adult female chickens. the ratio of circulating concentrations of triiodothyronine (t3) and thyroxine (t4) is substantially changed by fasting or prote ... | 1990 | 1974808 |
| increasing viral burden in cd4+ t cells from patients with human immunodeficiency virus (hiv) infection reflects rapidly progressive immunosuppression and clinical disease. | to determine over time the relation between viral burden and immunologic decline in patients with asymptomatic human immunodeficiency virus (hiv) infection. | 1990 | 1974752 |
| studies on the bovine major histocompatibility class i and class ii antigens using homozygous typing cells and antigen-specific bot4+ blast cells. | animals were identified from two sire lines as being homozygous for the class i bovine lymphocyte antigen (bola-a) w23. these animals were also shown to be homozygous for class ii antigens (bola-d) which, however, differed between the two sire lines. lymphocytes from these animals were then used either as stimulator cells in one-way mixed lymphocyte reactions (mlr) with all animals in the herd carrying the w23 antigen or as antigen presenting cells to bovine t4+ cell blasts. it was shown that, w ... | 1990 | 1974750 |
| disappearance of thyroid-stimulation blocking antibody by glucocorticoid therapy in a patient with primary myxedema who developed aortitis syndrome during l-thyroxine supplementation. | a 39-year-old woman with primary myxedema, who had the potent activities of thyrotropin-binding inhibitory immunoglobulins (tbii) and thyroid-stimulation blocking antibodies (tsbab), developed aortitis syndrome about 6 months after the initiation of l-thyroxine (l-t4) supplementation. a 35 mg daily dose of prednisolone for aortitis syndrome was initiated, and the dose was gradually reduced. tbii and tsbab activities were gradually decreased, and both reached normal levels (7.7% and 10.1%, respec ... | 1990 | 1974269 |
| chromosomal abnormality limited to t4 lymphocytes in a patient with t-cell chronic lymphocytic leukaemia. | cytogenetic, immunologic and dna studies were performed on a patient with the t-cell type of chronic lymphocytic leukaemia. standard g-banding karyotype analysis revealed clonal chromosome abnormalities with the karyotype 42-44,xy,-11,-12,-13,-16,-21,-22,i(8q),inv(14) (q11q32), t(15;?)(p11;?), +4-6mar/43-44,x,t(y;14)(p11;q11),-11,-12, -13,-21,-22,i(6p),i(8q),inv(14)(q11q32),t(15;?)(q11;?), +1-3mar. mac (morphology, antibody, chromosomes) methodology, which allows the immunophenotyping of mitotic ... | 1990 | 1974208 |
| [t-lymphocyte subsets in peripheral blood of patients with bone tumors]. | peripheral blood t-cell subsets of 54 patients with malignant or benign bone and soft tissue tumors and 20 age-and sex-matched normal controls were studied by using monoclonal antibodies. t-cell subsets were also studied before and after operation in ten patients with osteosarcoma. the number of t cells (okt 11) and okt 4 cells significantly decreased in malignant bone and soft tissue tumors. the number of okt 8 cells increased. statistically significant decrease in the t4/t8 ratio and the numbe ... | 1990 | 1974183 |
| mechanism of elongation of primed dna by dna polymerase delta, proliferating cell nuclear antigen, and activator 1. | in the presence of a single-stranded-dna-binding protein (ssb), the elongation of primed dna templates by dna polymerase delta (pol delta) is dependent on atp and two protein factors, activator 1 (a1) and proliferating cell nuclear antigen (pcna). we have examined the interaction of these proteins with (da)4500.(dt)12-18 by measuring their ability to form stable complexes with this dna. in the presence of atp, a1, pcna, and pol delta formed a stable complex with dna that could be isolated by gel ... | 1990 | 1974050 |
| development of non-hodgkin lymphoma in a cohort of patients with severe human immunodeficiency virus (hiv) infection on long-term antiretroviral therapy. | to describe the incidence of non-hodgkin lymphoma in a group of patients with symptomatic human immunodeficiency virus (hiv) infection receiving long-term dideoxynucleoside antiretroviral therapy. | 1990 | 1973886 |
| comparison of placebo with l-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre. | the efficacy of treatment with tsh-suppressive doses of l-thyroxine (t4, 2.5 micrograms/kg body weight daily) either alone or combined with carbimazole (cbz, 40 mg daily) was studied in 78 patients with sporadic non-toxic goitre in a prospective placebo-controlled double-blind randomised clinical trial. treatment was given for 9 months, with 9 months of follow-up. a response to treatment as measured by ultrasonography was found in 58% of the t4 group, in 35% of the t4/cbz group, and in 5% of the ... | 1990 | 1973768 |
| anal human papillomavirus infection among human immunodeficiency virus-seropositive and -seronegative men. | homosexual men are at high risk of anorectal human papillomavirus (hpv) infection, hpv-related anal cancer, and precancer, conditions known to increase with immunosuppression. the relationship between anal hpv infection, human immunodeficiency virus (hiv) infection, and immunosuppression was studied in homosexual men seen at a sexually transmitted disease clinic. history or presence of warts on rectal examination, and detection of anorectal hpv dna were each significantly associated with hiv ser ... | 1990 | 1973695 |
| the cd4 molecule and hiv infection. | cd4 (t4), a glycoprotein expressed largely on the surface of cells in the immune system, serves as the receptor for the human immunodeficiency virus, hiv. the isolation of the cd4 gene has permitted an analysis of the structure of cd4 and its role in both hiv infection and the immune response. recently, new classes of cd4-based therapeutics have been generated that interfere with hiv attachment to target cells. soluble cd4 proteins and cd4-based chimeric molecules are currently undergoing clinic ... | 1990 | 1973616 |
| effect of immunization against somatostatin in the pregnant ewe on growth and endocrine status of the neonatal lamb. | absorption of somatostatin (srif) specific antibodies from colostrum of ewes actively immunized against srif may improve growth rate of the neonatal lamb by neutralizing the inhibitory effects of srif on pituitary and thyroid function. growth and endocrine parameters in the offspring of srif immunized (si) and control (c) crossbred ewes were examined. lamb weight was recorded at birth and twice each week to 24 days of age. blood samples were collected prior to first suckle and twice each week. a ... | 1990 | 1973364 |
| [immunohistologic differentiation of interstitial infiltration cells in biopsies of transplanted kidneys]. | despite known morphological criteria of kidney allograft rejection a definite diagnosis of interstitial rejection in not possible in each case. therefore, by an enzyme histological differentiation of infiltrating cells in the transplant biopsy specimen this problem should be solved. it was used the pap method against pan t lymphocytes, t4 and t8 lymphocytes, monocytes and granulocytes. an acute interstitial rejection can be verified if 1. the number of lymphocytes and their subpopulations did in ... | 1990 | 1973324 |
| [proliferation of alveolar macrophages in pulmonary sarcoidosis correlates with markers of lymphocyte activity in bronchoalveolar lavage fluid]. | the proliferation of alveolar macrophages in 47 patients with pulmonary sarcoidosis was investigated using immune peroxidase stains with the monoclonal antibody ki-67. in patients suffering from sarcoidosis, a significantly elevated number of ki-67-positive alveolar macrophages was observed. the number of proliferating alveolar macrophages showed a significant positive correlation both with the number of lymphocytes in the bal fluid and with the t4/t8 quotient in the bal fluid of sarcoidosis pat ... | 1990 | 1973297 |
| [t4 and t8 lymphocytic populations after total hip replacement]. | immunosuppression is involved in the occurrence of sepsis after surgical trauma. a postoperative lymphocytopenia is a recognised fact. in the opposite, studies on t-lymphocytes helpers (cd 4) and suppressors (cd 8) resulted in conflicting results. the aim of this study was to assess the variations in these two t-lymphocyte sub-populations using strongly standardized conditions in order to minimize the risk of non specific variations: same surgeon, same surgical technique, blood samples collected ... | 1990 | 1973031 |
| clinical and immunological studies on patients with graves' disease preoperatively treated with corticosteroids and iodides. | the purpose of this study was to evaluate the acute effects of corticosteroid and iodide preoperative therapy in patients with graves' disease in terms of thyroid function and immunological parameters. the above combination was prescribed for 4 patients who had experienced severe side effects from antithyroid drugs (atd) in order to reduce the possibility of post-thyroidectomy thyroid storm. corticosteroids were employed daily for four days, and iodides were given daily for two weeks prior to th ... | 1990 | 1972765 |
| the action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase i-mediated conversion to membranolytic products. | the mechanism of toxicity for cytolytic lymphocytes of leu-leu-ome and related dipeptide derivatives was examined. selective inhibition of dipeptidyl peptidase i (dppi), a lysosomal thiol protease highly enriched in cytotoxic lymphocytes, prevented all natural killer (nk) toxic effects of such agents. however, many dppi substrates were found to possess no nk toxic properties. for some such agents, this lack of nk toxicity appeared to be related to the lack of uptake by lymphocytes. in this regar ... | 1990 | 1972727 |
| relative effects of different spinal autonomic nuclei on cardiac sympathoexcitatory function. | mean arterial pressure and heart rate were monitored in immobilized and artificially ventilated male wistar rats either anesthetized with pentobarbital or decerebrated at midcollicular level. the rate of increase in the left ventricular pressure was also monitored in order to compute contractility index. l-glutamate (1.77 nmole) was microinjected (10 nl) into the following autonomic nuclei of the spinal cord at c8 to t4 levels: 1) intermediolateral column (iml), 2) n. intercalatus spinalis (ic) ... | 1990 | 1972645 |
| [correlation of viral replication activity, the clinical phase of the disease and immunologic deterioration in hiv infection]. | the authors have studied the relationship among hiv replicative activity, expressed by hiv isolation from peripheral blood lymphocytes and p24 antigenemia detection, and the evolution of infection, in terms of stage of disease and t4 cells absolute number, in a group of 120 infected subjects. data presented indicate that the expression of viral gene products is related both to clinical and immunological deterioration and suggest that viral replication plays a central role in the progression of t ... | 1990 | 1972627 |
| an immune model defined by aids. | an immune control system is proposed which is made up of a pair of idiotypic t4 and t8 cells which recognize self-antigen, and a pair of anti-idiotypic t4 and t8 cells which recognize those idiotypic receptors. the protective and destructive elements of the control cells and their induced immunoglobulins are in equilibrium, allowing self-recognition and tolerance. one of the self-antigens monitored by the system is cd4, the t4 surface marker and also the hiv attachment site. in aids the hiv atta ... | 1990 | 1972537 |
| poliovirus vaccination responses in hiv-infected patients: correlation with t4 cell counts. | hiv infection is known to impair both cellular and humoral immunity. the antibody levels to poliovirus were measured in 17 hiv-infected and 3 hiv-seronegative homosexual men before and after vaccination with enhanced inactivated poliovirus vaccine (eipv). the subjects were tested for neutralizing antibodies to poliovirus types 1, 2, and 3; the number of peripheral blood t4 cells and lymphocyte responses after stimulation with phytohemagglutinin, concanavalin a, and pokeweed mitogen were measured ... | 1990 | 1972382 |
| pleiotropic effects of positively charged liposomes on immune functions. | positively charged liposomes have been shown to inhibit the proliferation of lymphocytes induced by various polyclonal activators. we demonstrated that this inhibition is essentially restricted to early phases of activation. b cell proliferation, induction of suppressor cells, and cytotoxic activities are all profoundly inhibited, whereas t4+ cells response to mitogenic stimulation is only moderately affected. the results are discussed in terms of membrane perturbations potentially induced by li ... | 1990 | 1972153 |
| increased plasma prolactin levels in ovariectomized thyroidectomized rats treated with estrogen. | it is well established that trh exerts a stimulatory effect on the secretion of both tsh and prl. clinically, hyperprolactinemia is usually present in hypothyroid women, but not men. in experimental studies, results vary because of the sexes, and treatments of animals differ. the purpose of this study was to further investigate the physiological control of prl secretion in hypothyroid female rats. adult female sprague-dawley rats that were surgically ovariectomized (ovx) and/or thyroidectomized ... | 1990 | 1972060 |
| identification of a putative cell receptor for human cytomegalovirus. | proteins from a variety of cell types were separated using sds-page, transferred to nitrocellulose filters, and probed with intact human cytomegalovirus (hcmv). virus bound to cell proteins was detected directly using 125i-labeled hcmv or indirectly using an immunologic assay with a secondary antibody labeled with 125i. using this approach proteins of molecular weights 32 and 34 kda were identified that would bind hcmv and were present on t4+ and t8+ lymphocytes, a b lymphoblastoid cell line, an ... | 1990 | 1971735 |
| asymptomatic patients with hiv infection. keeping them well. | primary care physicians need to be prepared to counsel and manage patients with human immunodeficiency virus (hiv) infection. asymptomatic seropositive patients should be seen quarterly, and t4 lymphocyte counts should be followed. other serologic markers that may detect disease progression are p24 antigen and beta 2 microglobulin. abnormalities in the levels of these markers may influence the decision to initiate early antiretroviral therapy. therapeutic regimens are now available for delaying ... | 1990 | 1971717 |
| development of diurnal rhythm in some metabolic parameters in foals. | 1. the development of diurnal rhythm activity of fdpa, aspat and a1at and in levels of cortisol, t3 and t4 was observed in the blood serum of six foals. 2. the studies began when a foal was 7 days old and were repeated every month until foals reached 1 year of age. blood samples were taken every 4 hr for one day each month. 3. as a control group four barren mares were used, kept and examined in the same conditions. 4. in mature mares, diurnal rhythms in activity of a1at (acrophase at 2200 hr), a ... | 1990 | 1971544 |
| depressed t-cell reactivity to recall antigens in rheumatoid arthritis. | reactivity toward soluble recall antigens (candida albicans, cytomegalovirus, herpes simplex, streptokinase-streptodornase, and influenza) was determined in cultures of peripheral blood mononuclear cells from 41 rheumatoid arthritis patients (with clinically active as well as inactive disease) and from 28 controls. in the group with clinically active rheumatoid arthritis we found an increased incidence of "anergy," defined as nonreactivity to three or more antigens. in an attempt to explain this ... | 1990 | 1970986 |
| reconstitution of t-cell function after cd6-depleted allogeneic bone marrow transplantation. | patients who undergo allogeneic bone marrow transplantation (bmt) are clinically immunodeficient for a prolonged period after engraftment. in the present study, we examined immune function after bmt in a series of patients who had received hla compatible sibling marrow grafts purged of t cells with anti-cd6 monoclonal antibody and complement. none of the patients in this analysis received immunomodulating agents and none had developed graft-versus-host disease (gvhd). initially after bmt, natura ... | 1990 | 1970938 |
| thyroid hormone action on lipid metabolism in humans: a role for endogenous insulin. | the effects of moderate hyperthyroidism on lipid metabolism were investigated in six healthy subjects before and after thyroxine treatment (300 micrograms/d). t4-treatment increased basal metabolic rate (+8%) and glucose oxidation (+87%), without affecting lipid oxidation, plasma free fatty acids, glycerol, and beta-hydroxybutyrate. during euthyroidism, a hypoinsulinaemic-euglycaemic 150-minute clamp protocol increased energy expenditure (+3%), lipid oxidation (+42%), plasma free fatty acids (+2 ... | 1990 | 1970848 |
| detection and quantitation of human immunodeficiency virus-infected peripheral blood mononuclear cells by flow cytometry. | a flow cytometric assay has been developed to detect and quantitate human immunodeficiency virus (hiv)-infected peripheral blood mononuclear cells obtained from hiv-seropositive patients. peripheral blood was obtained from patients attending an acquired immune deficiency syndrome clinic, and mononuclear cells were separated by centrifugation onto ficoll-hypaque. the cell layer at the interface was removed, washed in phosphate-buffered saline without ca2+ and mg2+, and fixed with 90% methanol, an ... | 1990 | 1970576 |
| thyroid regulation of body temperature in anaesthetized chickens. | 1. anaesthesia caused marked decreases in the plasma concentrations of triiodothyronine (t3) and thyroxine (t4) and in the body temperature of young fowl. 2. exogenous t4 or a thyroid hormone secretagogue (somatostatin antiserum), increased endogenous t3 and t4 concentrations and body temperature in conscious birds and prevented the body temperature decline in anaesthetized fowl. 3. these results provide further evidence for a role of t3 and t4 in temperature regulation in birds, particularly du ... | 1990 | 1970531 |
| neonatally-induced thermotolerance: physiological responses. | 1. broiler cockerels exposed to neonatal heat (35-37.8 degrees c for 24 hr) at 5 days of age experienced significantly lower mortality upon exposure to elevated temperatures (35-37.8 degrees c) at 43 days of age than did cockerels not given neonatal heat exposure. 2. no differences were found between neonatally stressed and neonatal control groups in water consumption, core and surface temperature, plasma t3 and t4, protein or glucose concentration when exposed to juvenile heat stress. 3. hetero ... | 1990 | 1970525 |
| [effects of somatostatin on human thyroid folliculi in vitro]. | somatostatin (srif) inhibits calcitonin and t3-t4 secretion in thyroid. we have investigated the in vitro effect of srif on the basal and tsh induced [3h]thy incorporation, thyroglobulin (tgb) rna and camp level in follicular cells, isolated from normal and adenomatous human thyroids. [3h]thy uptake has been evaluated as tca-precipitable material in 2, 4, 8, 24 h incubated follicles and 24 h incubated adherent cells. tgb rna has been quantified with cytoplasmic dot blot hybridization and camp le ... | 1990 | 1969742 |
| effect of imipramine on depression and immune status in a sample of men with hiv infection. | eleven men with major depression and human immunodeficiency virus (hiv) infection underwent an open trial of imipramine. eight of nine (89%) who completed 12 weeks responded. the mean decline in t4 cells from baseline was 100 at week 12 and 16 at week 26. no major exacerbations of hiv infection occurred. | 1990 | 1969246 |
| clinical, electrical and mechanical correlations during recovery from neuromuscular blockade with vecuronium. | in order to determine correlations between electromyographic (emg), mecanomyographic (mmg) and clinical criteria of adequate recovery from neuromuscular blockade with vecuronium, seven young healthy conscious volunteers were given subparalysing doses of vecuronium. during recovery from neuromuscular blockade, vital capacity, negative inspiratory pressure, peak expiratory flow rate and five-second head lift were assessed. neuromuscular monitoring included the evoked emg response of the adductor d ... | 1990 | 1968782 |
| the influence of thyroid hormone status on the hypothalamo-hypophyseal growth hormone axis. | growth hormone (gh) synthesis is known to be impaired by either abnormally high or low levels of thyroid hormone. to determine the effects of these conditions on the central regulation of gh secretion, we have examined their effects on the hypothalamic regulatory peptides gh-releasing hormone (gh-rh) and somatostatin (srif). in thyroidectomized rat hypothalamus, a dramatic increase in gh-rh mrna occurred in parallel with a decrease in peptide content. the significance of this phenomenon is uncer ... | 1990 | 1968379 |
| hyperprolactinemia in acute myeloid leukemia and indication of ectopic expression of human prolactin in blast cells of a patient of subtype m4. | the sera of 28 patients with acute myeloid leukemia aml--subtypes m1 to m6 were screened for human prolactin (h-prl). serum tsh (thyroid stimulating hormone), lh (luteinizing hormone), fsh (follicle stimulating hormone), beta-estradiol, free t4 (tetra-iodotyronine) and testosterone were also determined. it was found that in 16 of the 28 patients h-prl was significantly elevated while all other endocrine values were normal. in a patient subtype m4 with elevated serum h-prl we demonstrate by immun ... | 1990 | 1968111 |
| hiv-1 neutralizing antibodies in urine from seropositive individuals. | hiv-1 neutralizing activity was demonstrated in serum and 200-fold concentrated urine from individuals who were hiv-1 antibody positive in both their serum and urine, including aids-ks, aids-oi, arc, and asymptomatic patients. virus neutralization activity was detected in 23 of 56 (41.1%) of the serum samples and in 19 of 56 (33.9%) of the urine samples tested, with titers ranging from 1:8 to 1:256 and 1:1 to 1:4, respectively. the highest frequency of hiv-1 neutralizing activity (87.5%) and the ... | 1990 | 1968094 |
| changes in blood leucocyte populations induced by acute maximal and chronic submaximal exercise. | absolute (x 10(3).mm-3) or relative (%) numbers of blood leucocyte types (monocytes, lymphocytes, neutrophils) and lymphocyte subsets (t11+, t4+, t8+, b1+, and nkh1+) reacting with specific monoclonal antibodies were determined at rest, immediately after maximal exercise on a treadmill, in six controls (c), and in six young cyclists before training (bt) and after 5 months of training (at). maximal exercise significantly increased the absolute number (mobilization) of virtually all the types of l ... | 1990 | 1968005 |
| accessory function of interleukin-1 and interleukin-6: preferential costimulation of t4 positive lymphocytes. | two monocyte-derived cytokines, interleukin-1 (il-1) and interleukin-6 (il-6), have been reported to costimulate monocyte-depleted t cell populations in the presence of mitogen, and this effect has been attributed to an accessory function of these molecules. we have now examined further the accessory function potential of il-1 plus il-6, and examined how these cytokines promote t cell growth with mitogen. together, il-1 and il-6 additively and, to a small degree, synergistically promote the prol ... | 1990 | 1967955 |
| functions of replication factor c and proliferating-cell nuclear antigen: functional similarity of dna polymerase accessory proteins from human cells and bacteriophage t4. | the proliferating-cell nuclear antigen (pcna) and the replication factors a and c (rf-a and rf-c) are cellular proteins essential for complete elongation of dna during synthesis from the simian virus 40 origin of dna replication in vitro. all three cooperate to stimulate processive dna synthesis by dna polymerase delta on a primed single-stranded m13 template dna and as such can be categorized as dna polymerase accessory proteins. biochemical analyses with highly purified rf-c and pcna have demo ... | 1990 | 1967833 |
| sources of variability in repeated t-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important. | the study objective was to determine the causes and magnitude of absolute cd4 (t4) count variation in human immunodeficiency virus type 1 (hiv-1)-infected (+) adult males. we conducted a prospective, blinded, and controlled study of 22 adult military male outpatients, including 16 hiv(+) [12 in walter reed stage (wr-) 1 through 5, 4 in wr-6 (aids)], and 6 hiv seronegative (-) healthy controls. ten cd4+ cell counts were drawn within a 3-day interval from each patient at the following times: 0800, ... | 1990 | 1967309 |
| decreased adrenergic sensitivity in patients with hypothyroidism. | cardiovascular sensitivity to catecholamines was assessed in 15 patients with hypothyroidism (mean [+/- sem] thyroxine [t4] index 2.7 +/- 0.5 micrograms/100 ml, thyroid stimulating hormone [tsh] 136.9 +/- 48.3 microu/ml), aged 45 +/- 4 years and in 8 healthy control subjects. the study was repeated in 10 patients with hypothyroidism 4.0 +/- 0.5 months after thyroid replacement therapy (t4 index 9.9 +/- 2.1 micrograms/100 ml, tsh 3.5 +/- 1.3 microu/ml). in addition, basal, average and maximal hea ... | 1990 | 1967261 |
| natural history of mixed chimerism after bone marrow transplantation with cd6-depleted allogeneic marrow: a stable equilibrium. | mixed hematopoietic chimerism (mc) is a common finding after allogeneic bone marrow transplantation (bmt), but the natural history of this phenomenon remains unclear. to understand the evolution and the implications of this finding, we performed a prospective analysis of the development of mixed chimerism in 43 patients with hematologic malignancies who received bone marrow (bm) from human leukocyte antigen (hla)-identical sibling donors. t-cell depletion in vitro with anti-t12 (cd6) monoclonal ... | 1990 | 1967216 |
| a subpopulation of the avian erythroblastosis virus v-erba protein, a member of the nuclear hormone receptor family, is glycosylated. | the v-erba oncogene of avian erythroblastosis virus is derived from a cellular gene for a thyroid hormone (t4/t3 thyronine) receptor and encodes a dna-binding protein found principally in the nucleus of the infected cell. i report here that a subpopulation of the v-erba protein is glycosylated. the v-erba protein, therefore, is another member of the newly recognized family of eucaryotic transcription factors and related polypeptides which are glycoproteins. | 1990 | 1967151 |
| [study of two goitrous endemic areas in niger: belley-koira and tiguey-tallawal]. | the present work reports the clinical and laboratory findings in two endemic areas in niger: tiguey-tallawal and belley-koira. the goitrous subjects (n = 293), mainly children and adolescents, have clinical evidence of euthyroidism but with biological criteria of hypothyroidism in 25% of cases as shown by the decrease of the total serum t4 and the increase of serum tsh. iodine deficiency intake evaluated by the determination of urinary iodine in single urine specimens is the permissive and main ... | 1990 | 1966663 |
| [the population variability of cortisol and thyroid hormone levels in northern khanty]. | the cortisol, thyroid-stimulating hormone (tsh), thyroxine (t4) and triiodothyronine (t3) levels were studied in the north khanty population. 718 individuals of both sexes aged over 10 years were examined in august, november and december. the cortisol and tsh levels were characterized by nonlinear age dependence. negative linear correlations between age and hormone levels were more obvious for t3 and t4 and higher in males. the mean plasma cortisol and t3 levels were significantly higher in male ... | 1990 | 1966096 |
| thyroid hormone effects upon na+k+ dependent adenosine triphosphatase activity of microsomal fraction of liver, muscle and brain of toad bufo melanostictus. | na+k(+)-atpase activity in the liver and muscle microsomal membranes have been determined by different doses (0.1, 0.25, 0.5, 1 and 2 micrograms/gm of body weight) of l-triiodothyronine and l-thyroxine in the toad, bufo melanostictus. the minimum effective dose of t3 was 0.5 microgram/g in case of both liver and muscle to stimulate the enzyme activity and there was dose dependent rise between t3 at the doses of 0.5 and 1 microgram/g. t3 at the doses of 1 and 2 micrograms/g produced more or less ... | 1990 | 1966031 |
| the differentiation-inducing agent sodium butyrate produces divergent effects on albumin and thyroxine-binding globulin synthesis by human hepatoblastoma-derived (hep g2) cells. | the addition of sodium butyrate, a differentiation-inducing agent, to the culture medium of human hepatoblastoma-derived (hep g2) cells, produced a dose-dependent and time-dependent increase in albumin (alb) and decrease in t4-binding globulin (tbg) synthesis and secretion. in the presence of 0.01 to 2.0 mm sodium butyrate, newly synthesized [35s]alb progressively increased up to 139% of control cultures grown in the absence of sodium butyrate, whereas tbg synthesis was already slightly inhibite ... | 1990 | 1965315 |
| evidence for equimolar synthesis of double-strand rna and minus-strand rna in rotavirus-infected cells. | the genome of the rotaviruses consists of eleven segments of double-strand rna (dsrna). each segment is replicated asymmetrically with viral plus-strand rna, i.e. messenger (m)rna, serving as the template for the synthesis of minus-strand rna to produce dsrna. to examine the relative frequency of replication of each of the eleven genome segments, ma104 cells were infected with low (3rd) and high (12th) passage stocks of simian rotavirus sa11. the total cytoplasmic rna of the infected cell was ra ... | 1990 | 1963957 |
| influence of age on the thyroid hormone-induced up-regulation of beta-adrenoceptors in mouse brain cortex. | the influence of ageing on the ability of the brain cortex beta-adrenoceptors to be regulated by very short stimulation with thyroid hormones has been investigated. experiments were performed in 3-, 10-, 17- and 22-month-old mice using both thyroxine (t4) and triiodothyronine (t3) as stimulators and analyzing beta-adrenergic receptor characteristics 15 and 60 min after hormone injection. results showed that a statistically significant up-regulation is present in both young and old mice when trea ... | 1990 | 1963874 |
| pirarubicin phase ii study in untreated metastatic small-cell lung carcinoma. a cooperative study of the groupe français de pneumo-cancérologie (gfpc). | pirarubicin (thp) (roger bellon laboratory, france) is a new anthracycline under clinical development. in order to assess the efficacy and toxicity of the drug in small-cell lung carcinoma (sclc), we have undertaken this trial in front-line therapy in patients with metastatic disease, ps less than 3 and at least one evaluable lesion. responses were assessed after two cycles of thp (60 mg/m2 i.v. bolus every 3-4 weeks) and a further cross over to vp16 + cddp (three cycles) was systematic whatever ... | 1990 | 1963272 |
| [immunologic studies in patients with ovarian carcinoma during radio-chemotherapy. i. studies of lymphocyte subpopulations]. | in this article we have studied the behaviours of different lymphocyte subpopulations (t11, t8, t4, b4 and b1) in the peripheral blood of 60 patients suffering from ovarian cancer during radio- and chemotherapy with the apaap-technique. the most important results of our study are that compared with the chemotherapy the radiotherapy causes greater lymphocyte depression, that the subpopulations of t-lymphocyte with the exception of t8 show greater radio-sensitivities than b-lymphocyte, that t8-sub ... | 1991 | 1962278 |
| [acquired immunodeficiency syndrome in the province of cádiz. a study of 269 consecutive patients]. | the epidemiological characteristics, clinical manifestations and survival were analyzed in 269 patients with acquired immunodeficiency syndrome (aids) diagnosed in the province of cadiz up to june 1970. | 1991 | 1961045 |
| blood transfusions and phenotypic immune profile in head and neck cancer patients undergoing surgical resection. | recent papers in the general surgery and otolaryngology literature have shown a positive correlation between blood transfusion and decreased survival in cancer patients. this is felt to be due to immunosuppression (not yet defined) induced by the transfusion. we prospectively analyzed the peripheral blood immune profiles of patients undergoing surgery for control of their squamous cell carcinoma of the upper aerodigestive tract. pre- and postoperative profiles were examined. t4, t8, natural kill ... | 1991 | 1960784 |
| a high prevalence of hypothyroidism in association with endemic goitre in zimbabwean schoolchildren. | one-hundred-and-eighty-eight ostensibly normal, pubertal schoolchildren, aged 9-16 years, residing in chinamora communal land, zimbabwe, had blood taken to assess thyroid function. total goitre rate in the area was 44 per cent in primary schoolchildren: 91 of the subjects tested were goitrous. thyroid stimulating hormone levels (tsh) were above normal (5.0 mu/l) in 66 subjects overall, of whom 39 were goitrous. the 36 subjects with tsh levels above 7.0 mu/l also had total thyroxine (t4) estimati ... | 1991 | 1960780 |
| effect of maternal administration of thyrotropin releasing hormone on the preterm fetal pituitary-thyroid axis. | we evaluated the response of preterm fetuses to maternal intravenous injection of 400 micrograms of thyrotropin releasing hormone (trh) between 30 minutes and 5 hours before delivery (n = 12). an additional seven mothers received saline solution and served as control subjects. there were no statistically significant differences in gestational age, birth weight, or apgar scores between groups. at delivery, concentrations of maternal thyrotropin were elevated in the trh group compared with the con ... | 1991 | 1960619 |
| cleavage reaction of a synthetic oligoribonucleotide corresponding to the autocleavage site of a precursor rna from bacteriophage t4. | a fragment (guuucguacaaac) having a consensus sequence for the self-cleavage domain in a precursor of an rna molecule from t4-infected escherichia coli cells (p2sp1; precursor of species 1) was chemically synthesized and found to be cleaved either between ca (139-140) or between ua (137-138) in the presence of monovalent cations and a non-ionic detergent. the cleaved products had 5'-hydroxyl and 3'-phosphate groups, of which some were in the form 2',3'-cyclic phosphates. | 1991 | 1959662 |
| local generation of triiodothyronine by the mammary gland as a source of measurable quantities of the hormone in milk. | simple diffusion or facilitated diffusion, by a carrier system represented by binding sites on plasma membranes, are thought to be responsible for thyroid hormones (th) uptake by tissues. the concept implies the existence of an equilibrium ratio between plasma and cellular hormone content. studies of th presence in milk have shown that the passage of th through mammary gland differs between t4, rt3, and t3, and only t3 exists in the milk in measurable amounts (without definite relationship betwe ... | 1991 | 1958839 |
| [thyroid response to exogenous tsh stimulation in diabetic patients]. | complicated diabetic patients have a marked decrease of plasmatic level of t3 and a less important decrease of t4. they are caused by the alteration of the extra-thyroid t3 formation from t4 and lower tsh release. 11 patients with a different metabolic state had a basal determination of t3 and t4 and 6 hours after the administration of 5 units of tsh intramuscular in order to see whether those changes described previously existed in any other intrinsic thyroid alteration secondary to complicated ... | 1991 | 1958777 |
| the effect of subarachnoid lidocaine and combined subarachnoid lidocaine and epidural bupivacaine on electrical sensory thresholds. | eight patients undergoing abdominal surgery received a combination of spinal anesthesia (catheter at l2-3 level) and epidural anesthesia (catheter at t10-11 level). sensory thresholds to electrical stimulation were measured at the s1, l1, t10, and t5 levels before injection, after spinal anesthesia, and after the addition of epidural anesthesia. subarachnoid injections with 5% lidocaine (without dextrose) were given until a t4 sensory level to pinprick was obtained (mean dose, 175 mg lidocaine). ... | 1991 | 1958602 |
| [effects of long-term administration of theophylline on the pituitary-thyroid axis in asthmatics]. | the effects of long-term administration of theophylline on the pituitary-thyroid axis were investigated. in the first study, the changes in serum thyroid hormone, tsh and cortisol levels were examined before and after 2 week-administration of sustained-release theophylline in 5 normal and 10 asthmatic subjects. in the normal subjects, the hormone levels did not change before or after theophylline administration. on the other hand, in the asthmatics, serum tsh levels increased (p less than 0.05) ... | 1991 | 1958132 |
| comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal t4 metabolism and thyroid gland function in rats. | we studied the effects of propylthiouracil (ptu), amiodarone (amio), diphenylhydantoin (dph), phenobarbital (pb), and 3-methylcholanthrene (mc) on thyroid histomorphology, on the hepatic and renal enzymes involved in endogenous and exogenous metabolism, and on the plasma levels and pharmacokinetics of thyroid hormones after 7 and 14 days of treatment. ptu and pb, by decreasing both serum tetraiodothyronine (t4) and triiodothyronine (t3), induced a massive increase in serum thyrotropin (tsh) and ... | 1991 | 1957312 |
| [sonographic assessment of the extent of colonic wall lesions exemplified by colonic tumors]. | in order to reveal sonographic accuracy in imaging gut wall lesions transcutaneous ultrasonic findings in 78 colonic wall tumours (6 polyps sized more than 1 cm, 68 colonic carcinomas, 1 pancreatic carcinoma, 1 gallbladder carcinoma and 2 benign diverticulitis tumours) were staged according or similar to tnm classification from 1987 and compared to histologic findings. 62 ultrasonic stagings were correct, sensitivity and specificity of u/t1 to u/t4 stagings ranged from 0.64 to 0.89 resp. 0.7 to ... | 1991 | 1957150 |
| bladder carcinoma--a 20-year review of radical irradiation therapy. | between 1967 and 1986, 319 patients, judged unsuitable for cystectomy, were scheduled to receive curative radiation treatment for transitional cell cancer of the urinary bladder. crude and corrected 5-year survival for all stages were 18% and 28%, respectively. corrected 5-year survival by stage was: t1-57%, t2-31%, t3-16% and t4-6%. fifty-seven patients (18%) never completed the scheduled treatment and all but two of them died in a short time from tumour progression. local response could be eva ... | 1991 | 1957001 |
| the changes of thyroid hormone during pharmacological treatment of panic disorder patients. | 1. because imipramine has lowered t4 in uncontrolled studies we examined the effect of imipramine on serum thyroid levels in panic disorder patients in a double-blind placebo and diazepam treatment controlled study. 2. treatment with imipramine (10 subjects) was associated with a significant decrease of t4 and fti and treatment with diazepam (8 subject) was associated with a significant decrease of t4. however, there was no significant difference across treatment groups. 3. this finding suggests ... | 1991 | 1956988 |
| causes of breast cancer misdiagnosis at physical examination. | 2740 consecutive breast cancers undergoing physical examination were reviewed. ninety-two subclinical cancers detected at mammography were excluded from further evaluation and the study focused on palpable false benign cancers. the sensitivity of physical examination varied according to t category (tis = 0.48, t1 = 0.70, t2 = 0.90, t3 = 0.89, t4 = 0.93), age (20-29 = 0.77, 30-39 = 0.58, 40-49 = 0.75, 50-59 = 0.84, 60-69 = 0.90, greater than 69 = 0.94) and operator (range 0.69-0.89), a significan ... | 1991 | 1956468 |
| thyroid and ovarian function in infertile women. | the aim of this study was to examine more closely the interaction between thyroid function and pituitary--ovarian axis in infertile women. in 185 infertile women without clinical signs of thyroid dysfunction, trh-tests (tsh basal and 30 min after 200 micrograms trh i.v.) were performed in the early follicular phase in addition to routine hormonal checks (gonadotrophins, oestradiol, dheas, testosterone, prolactin). the women were classified as euthyroid (n = 74; tsh stim 5-20 mu/l), latent hypert ... | 1991 | 1955537 |
| immunological and virological status of a hemophiliac infected with human t cell lymphotropic virus type 1 and human immunodeficiency virus type 1, and results of therapy. | the immunological and virological status of three hemophiliacs infected with human immunodeficiency virus type 1 (hiv-1) was monitored for 11 months. one of these patients was also infected with human t cell lymphotropic virus type 1 (htlv-1), and hiv-1 could be isolated only from this patient among the three subjects. the doubly infected subject had the fewest t4 (helper) lymphocytes and the highest proportion of t8 lymphocytes with dr human leukocyte antigens (dr-ag). the serum level of hiv-1 ... | 1991 | 1954356 |
| [testing of extracted particles from winter rapeseed with different glucosinolate levels in swine with special reference to the iodine supply. 2. thyroid hormone status, histomorphometric findings and iodine content of the thyroid gland]. | in the experiment, 2 x 12 growing pigs received 19 or 6.7 mmol glucosinolates + aglucones/kg feed via conventional rapeseed meal (rsm) or rsm of a newly bred variety. these pigs and 24 littermates pair fed with a soya bean meal (sbm) diet were subdivided in groups of 4 animals each. their diet contained either no supplementary iodine or an iodine supplementation of up to 1 mg/kg feed. in the rsm and sbm groups the lack of additional iodine lowered the serum t4 and t3 content below the detection ... | 1991 | 1953333 |
| intraoral soft tissue reconstruction after cancer ablation: a comparison of the pectoralis major flap and the free radial forearm flap. | we compared, by retrospective chart review, the free radial forearm flap and the pectoralis major flap in repairing intraoral soft tissue defects resulting from tumor ablation. statistical significance of differences was determined using fisher's exact test and chi-square analysis. fifty-one free flap and 126 musculocutaneous flap transfers were analyzed. the former were used more often for defects in the anterior part of the oral cavity, whereas the latter were used more frequently in the poste ... | 1991 | 1951897 |
| circulating thyroglobulin measurements by homologous radioimmunoassay in dogs with thyroid carcinoma. | circulating thyroglobulin was measured in 20 dogs with thyroid cancer, using a homologous polyclonal radioimmunoassay. plasma tg levels exceeded the normal range in 14 (70%) dogs, and ranged from 6 to 2902 micrograms/l (median 608). plasma tg levels tended to decrease from follicular carcinomas to solid-follicular carcinomas, to solid carcinomas (p less than 0.05). plasma tg levels were also higher in scintigraphically hot tumours than in cold ones. other relationships between circulating tg and ... | 1991 | 1950342 |
| serum pattern of thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) in fed and fasted cocks following trh stimulation. | food deprivation for 27 and 75h in cocks decreased serum levels of t3 maximally by 61.1% and increased the level of rt3 by 51.4% and that of t4 by 22.4%. injection of a single dose of trh (10 micrograms/kg b.w.) increased serum levels of all 3 iodothyronines in both fed and food-deprived animals. in fasted, trh-treated birds the peak of serum rt3 was 80.5 and 73.3% above control levels in 27- and 75-hr food-deprived cocks, respectively (fed birds: 14.6 and 9.7%); the relevant data for t3 were: 7 ... | 1991 | 1950229 |
| intra-arterial chemotherapy for bladder cancer by insertion of catheter from inferior gluteal artery. | thirty-four patients with locally advanced bladder cancer have been treated with selective intra-arterial infusion of cddp and/or adm (ia therapy) prior to planned surgical resection. follow-up ranged from 25 to 108 months (median 61). initial tumor stage was ct2 in 10 patients, ct3 in 19 and ct4a in 5. catheterization technique: gluteal muscles were dissected gently along the muscle fiber to expose the inferior gluteal artery with the patients in prone position, then the catheter was inserted. ... | 1991 | 1949365 |
| hepatic udp-glucuronyltransferase(s) activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers. | induction of hepatic udp-glucuronyltransferase(s) (hudp-gt(s] activity toward thyroid hormones and the relationship between the activity and the serum thyroid hormones or the thyroid stimulating hormone (tsh) level were examined in male sprague-dawley rats after four consecutive ip doses of various hepatic enzyme inducers at 75-150 mg/kg/day. hudp-gt activity toward thyroxine (t4; hudp-gt-t4) was induced by treatment with beta-naphthoflavone, 3-methylcholanthrene (3-mc), polychlorinated biphenyl ... | 1991 | 1949040 |
| effects of experimental hyper- and hypothyroidism on natural defense activities against lewis lung carcinoma and its spontaneous pulmonary metastases in c57bl/6 mice. | the effects of expermentally induced hyper- and hypothyroidism on the growth and development of spontaneous pulmonary metastases of lewis lung carcinoma (3ll) cells were studied in a murine system. progression of 3ll tumors growing in mice was associated with significant reduction in the serum levels of t3 and t4. subcutaneous (s. c.) injections (3 times/week) of t3 resulted in a hyperthyroid state with elevated t3 and reduced t4, whereas treatment with t4 induced a hyperthyroid state with eleva ... | 1991 | 1948998 |
| [interstitial and percutaneous radiotherapy after limited surgery in carcinoma of the oral cavity]. | from 1.1. 1986 to 31.12. 1990 50 patients with epidermoid carcinoma of the floor of the mouth and the mobile tongue (stage t1 18, stage t2 20, stage t3 eight and stage t4 four patients) were treated by surgery, 192-iridium implantation using the plastic tube technique and percutaneous irradiation. surgery was performed as enoral resection (35 patients) or en bloc tumour resection with part of the mandible and flap reconstruction (15 patients). interstitial therapy was considered as a boost to pr ... | 1991 | 1948644 |
| [radiotherapy in the interdisciplinary approach to the treatment of bladder carcinoma]. | bladder cancer accounts for approximately 3% of all malignancies. about 70% of bladder cancers are superficial tumors (ta, tis, t1), the remaining 30% are muscle-invasive (t2-4). important prognostic factors include tnm-stage, histologic grade, multifocality, associated tis, and residual tumor after tur. superficial cancers are managed by tur and, if necessary, intravesical chemotherapy, and bladder preservation is possible. in case of t1g3-cancers, we favour tur plus irradiation with a moderate ... | 1991 | 1948642 |
| preoperative detection of intrathoracic tumor spread of esophageal cancer: endosonography versus computed tomography. | the results of endosonography and computed tomography, using an optimized ct technique, have been compared in the preoperative detection of intrathoracic tumor spread of esophageal cancer. in 22/40 patients with esophageal tumors complete passage of the ultrasonic endoscope was possible. endosonography was superior to ct in the assessment of early stage of esophageal tumor (t1-2). out of 9 tumors confined to the esophageal wall, 8 were classified correctly by endosonography and only 5 by compute ... | 1991 | 1948618 |
| [a case of rheumatoid arthritis complicated with idiopathic thrombocytopenic purpura and hashimoto's disease]. | a 37 year old nurse with the rare combination of idiopathic thrombocytopenic purpura (itp), hashimoto's thyroiditis and rheumatoid arthritis (ra) was reported. in 1983, six years before her final diagnosis was made, she presented with purpura over her extremities and swelling of the cervical lymph nodes. laboratory findings showed the following: platelet count 15 x 10(3)/microliters, the number of megakaryocyte without platelet production in bone marrow was increased, platelet life span (t1/2) 1 ... | 1991 | 1948458 |
| hormonal changes in severely uncontrolled type 1 (insulin-dependent) diabetes mellitus. | to investigate endocrinological changes associated with severely uncontrolled type 1 (insulin-dependent) diabetes mellitus 27 patients (19 men, eight women) with ketoacidosis or severe ketonuria (= group 1) were examined on admission and after recovery. for comparison 13 non-ketotic patients (seven men, six women), admitted for adjustment of treatment because of poor diabetic control (= group 2), and 20 healthy controls were studied. on admission, the serum testosterone levels in men were lower ... | 1991 | 1947723 |
| [exclusive radiotherapy of carcinoma of the hypopharynx. retrospective study of a series of 100 patients]. | from january 1980 to december 1987, 100 patients with carcinoma of the hypopharynx, staged according to tnm (uicc-1978) criteria, received exclusive radiation therapy at the radiotherapy department of the general hospital of varese. the median follow-up is 9 months (range: 1-97). irradiation was delivered with 60co or with 10 mv photons and tissue-equivalent bolus. two opposed parallel lateral fields or rotational technique were used, with progressive shrinking of treated volume in order to spar ... | 1991 | 1947270 |
| effect of 5-methylcytosine on the stability of triple-stranded dna--a thermodynamic study. | we have previously shown that the pyrimidine oligonucleotide 5'cttcctcctct (y11) recognizes the double-helical stem of hairpin 5'gaaggaggaga-t4-tctcctccttc (h26) by triple-helix formation (1). in this paper, we report the effect on triplex formation of substituting the cytosine residues of y11 with 5-methylcytosines (5mey11). in addition, we have studied the thermodynamics of the interaction between h26 and 5mey11. the results can be summarised as follows: (i) gel electrophoresis shows that at t ... | 1991 | 1945840 |
| [immunologic studies in myelodysplastic syndrome]. | myelodysplastic syndrome is a clonal stem-cell disease, which predominantly involves myeloid cell lines. however, several observations refer to a possible pathological condition of the lymphoid system as well. because of these controversial data, we investigated 25 patients with mds at our clinic. absolute lymphocyte counts, lymphocyte subpopulations (using methods of mat, okt 3, 4, 8, leu7), t and b rosette tests and quantitative tests of immunoglobulins were made possibly during diagnosis or b ... | 1991 | 1945366 |
| [the role of radiotherapy in the treatment of vulvar tumors]. | carcinoma of the vulva is relatively rare, making up 3% to 4% of all primary genital cancer. it is a disease of the elderly. the authors treated from 1976 to 1987 twenty-one patients with locally advanced squamous vulvar cancer (6 t2; 12 t3; 3 t4). nine of these patients were submitted to radiotherapy alone; the others were treated with a combination of surgery and postoperative radiation. two and five years disease-free survival rate was 33% and 19%. the rate of radiotherapy sequelae has been l ... | 1991 | 1945023 |
| [laurence-moon-biedl syndrome associated with tertiary hypothyroidism. a case report]. | the laurence-moon-biedl syndrome is characterized by retinitis pigmentosa, obesity, psychic disturbances, polydactily and hypogonadism. renal involvement is also a frequent finding and renal failure may be fatal for the patient. on the basis of the consanguinity and the familiarity of this syndrome. r.c., a 47 years old male, with cardiovascular failure and marked psychic sleepiness has been studied. the patient showed the full picture of this syndrome. the thyroid function has been studied and, ... | 1991 | 1945010 |
| [two cases of tsh-secreting pituitary adenoma; endocrinological, diagnostic and therapeutic approach to the disease]. | two cases of tsh-secreting pituitary adenoma were reported. endocrinological and immunohistochemical features of these cases were described and problems in diagnosis and treatment of the rare disease are discussed. [case 1] a 28 year-old woman suffered from hyperthyroidism with a relatively high value of serum tsh (t3; 350 ng/dl, t4; 10.0 micrograms/dl, tsh; 24.5 microu/ml). she was treated with antithyroid drug and then underwent subtotal thyroidectomy. although the levels of serum t3 and t4 we ... | 1991 | 1944800 |
| inhibition by etomoxir of carnitine palmitoyltransferase i reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus. | to determine the therapeutic effect of the carinitine palmitoyltransferase i (cpt-i) inhibitor, etomoxir, eight hospitalized obese non-insulin-dependent diabetes mellitus (niddm) patients were studied (body mass index [bmi], 28.7 +/- 1.3 kg/m2; age, 54 +/- 8 years [means +/- se]) at baseline (placebo = t1), and after oral etomoxir (50 mg/d = t2, 100 mg = 3, 150 mg = t4, 200 mg = t5, placebo = t6). fasting blood glucose (mmol/l), triglycerides (mmol/l), cholesterol (mmol/l), free fatty acids (mum ... | 1991 | 1943747 |
| clinical utility of red blood cell carbonic anhydrase i and zinc concentrations in patients with thyroid diseases. | we have recently reported that, in patients with hyperthyroidism, the red blood cell (rbc) carbonic anhydrase i (cai) and zinc (zn) concentrations both reflect the patient's integrated thyroid hormone level over the preceding few months. in this study, we evaluated the clinical usefulness of determining the rbc cai and zn concentrations in patients with various types of thyroid disease. six patients with painless thyroiditis (pt) had normal rbc cai concentrations and the two patients tested had ... | 1991 | 1943730 |
| aids: immunologic abnormalities following human immunodeficiency virus infection. | following human immunodeficiency virus (hiv) infection, there is an ordered progression of immunologic abnormalities that results from the selective infection of the t4 helper/inducer subset of t lymphocytes. the loss of helper t-cell function disrupts both the cellular and humoral aspects of the immune response. the t lymphocytes decrease in both number and function. the peripheral blood b lymphocytes demonstrate marked polyclonal activation and are unable to mount a serologic response to new a ... | 1991 | 1942190 |
| developmental toxicity of diphenyl ether herbicides in nestling american kestrels. | beginning the day after hatching, american kestrel (falco sparverius) nestlings were orally dosed for 10 consecutive days with 5 microliters/g of corn oil (controls) or one of the diphenyl ether herbicides (nitrofen, bifenox, or oxyfluorfen) at concentrations of 10, 50, 250, or 500 mg/kg in corn oil. at 500 mg/kg, nitrofen resulted in complete nestling mortality, bifenox in high (66%) mortality, and oxyfluorfen in no mortality. nitrofen at 250 mg/kg reduced nestling growth as reflected by decrea ... | 1991 | 1942122 |
| systematic mutation of bacteriophage t4 lysozyme. | amber mutations were introduced into every codon (except the initiating aug) of the bacteriophage t4 lysozyme gene. the amber alleles were introduced into a bacteriophage p22 hybrid, called p22 e416, in which the normal p22 lysozyme gene is replaced by its t4 homologue, and which consequently depends upon t4 lysozyme for its ability to form a plaque. the resulting amber mutants were tested for plaque formation on amber suppressor strains of salmonella typhimurium. experiments with other hybrid p ... | 1991 | 1942069 |
| cumulative site-directed charge-change replacements in bacteriophage t4 lysozyme suggest that long-range electrostatic interactions contribute little to protein stability. | bacteriophage t4 lysozyme is a basic molecule with an isoelectric point above 9.0, and an excess of nine positive charges at neutral ph. it might be expected that it would be energetically costly to bring these out-of-balance charges from the extended, unfolded, form of the protein into the compact folded state. to determine the contribution of such long-range electrostatic interactions to the stability of the protein, five positively charged surface residues, lys16, arg119, lys135, lys147 and a ... | 1991 | 1942034 |
| asymptomatic hypothyroidism and hypercholesterolaemia. | hypothyroidism is a cause of secondary hyperlipidaemia. this study investigates the frequency of biochemically diagnosed hypothyroidism and its relationship with plasma cholesterol concentration in apparently healthy people. thyroid function tests (total t4, tsh, and free t4) were performed on 272 apparently healthy men and women (179 vegetarians, 93 meat eaters) with a plasma cholesterol concentration above 7 mmol/l and on 90 individuals with a plasma cholesterol below 4.1 mmol/l who were match ... | 1991 | 1941853 |
| detection of autoantibodies against 3,5,3'-triiodothyronine in a hyperthyroid patient (a case report). | a 35-year-old female patient was evaluated for thyroid function and was found to be hyperthyroid clinically and by laboratory tests. during the course of treatment with neomercazole, she developed a bizarre picture with consistently low t3 levels irrespective of her clinical thyroid status and other laboratory tests like serum t4 and tsh levels. the serum of the patient when analysed for the presence of autoantibodies was positive for those against t3. the presence of t3 autoantibodies was confi ... | 1991 | 1941692 |