Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| treatment of acute exacerbations in early multiple sclerosis: cyclosporin a or prednisolone? | twenty-six acute exacerbations in 26 patients with early definite multiple sclerosis (ms) were treated with oral cyclosporin-a (cya) or oral prednisolone in a double-blind, controlled and randomized trial. the duration of the treatment was 6 weeks. all of the patients showed improvement during the treatment. there were no differences in outcome between patients on cya (7.5 mg/kg) or prednisolone (decreasing doses from 0.8 mg/kg) during the 6 week treatment. however, the improvement of clinical s ... | 1991 | 2011945 |
| prediction of the thermodynamics of protein unfolding: the helix-coil transition of poly(l-alanine). | the method given earlier for predicting the thermodynamics of protein unfolding from the x-ray structure of a protein is applied here to the poly(l-alanine) helix. first, the fitting parameters derived earlier from a data base of 10 proteins were used to predict the unfolding thermodynamics of 4 other proteins. the agreement between the observed and predicted values is comparable to that found for the 10 proteins studied initially. next, the temperature dependences of the gibbs energy and enthal ... | 1991 | 2011595 |
| ligation with t4 rna ligase of an oligodeoxyribonucleotide to covalently-linked cross-sectional base-pair analogues of short, normal, and long dimensions. | compounds that are covalent analogues of nucleic acid base pairs of normal, long, and short c1' to c1' dimensions [b. devadas and n.j. leonard (1990) j. am. chem. soc., 112, 3125-3135.] have been added to the oligodeoxyribonucleotide d(a)6 with bacteriophage t4 rna ligase as a prelude to placing them at defined loci within nucleic acid duplexes. analogue cross sections that represent a normal watson-crick base pair as well as a pyrimidine-pyrimidine and a purine-purine apposition were ligated in ... | 1991 | 2011530 |
| the cellular component in the parietal infiltrate of inflammatory abdominal aortic aneurysms (iaaa). | eight cases of inflammatory abdominal aortic aneurysm (iaaa) (group i) and a control group of ten cases of atherosclerotic abdominal aortic aneurysm (aaa) with little or no parietal inflammatory infiltrate (group ii) were studied; using light microscopy, transmission electron microscopy (tem), and immunohistochemistry. these were used to define cell composition in the inflammatory process, the degree of cell activation and alteration of connective tissue. large numbers of b lymphocytes were pres ... | 1991 | 2009988 |
| effects of mutations of the bulged nucleotide in the conserved p7 pairing element of the phage t4 td intron on ribozyme function. | the p7 element of group i introns contains a semiconserved "bulged" nucleotide, a c in group ia introns (nt 870 in the td intron) and an a in group ib introns [cech, t.r. (1988) gene 73, 259-271]. variants u870, g870, and a870, isolated by a combination of in vitro and in vivo genetic strategies, indicate that c and a at position 870 are consistent with splicing whereas u and g are not. although mutants g870 and u870 could be activated in vitro by increasing the mg2+ concentration, their km for ... | 1991 | 2009267 |
| simulation analysis of the stability mutant r96h of t4 lysozyme. | free energy simulation methods are used to analyze the effects of the mutation arg 96----his on the stability of t4 lysozyme. the calculated stability change and the lack of significant structural rearrangement in the folded state due to the mutation are in agreement with experimental studies [kitamura, s., & sturtevant, j. m. (1989) biochemistry 28, 3788-3792; weaver, l. h., et al. (1989) biochemistry 28, 3793-3797]. by use of thermodynamic integration, the contributions of specific interaction ... | 1991 | 2009262 |
| compensatory parathyroid hypertrophy after hemiparathyroidectomy in rats feeding a low calcium diet. | the functional and anatomic compensatory response of the parathyroid gland was examined in hemiparathyroidectomized (hptx) rats whose parathyroid hormone (pth) secretion was stimulated by a low calcium diet. these responses were compared with those observed in the thyroid gland of hemithyroidectomized (htx) rats. rats kept on a low calcium diet for 10 days were subjected to hptx, htx, or sham operations. throughout the experiment (up to 28 days after surgery), serum calcium levels of hptx rats w ... | 1991 | 2007228 |
| chemical synthesis of oligodeoxynucleotide dumbbells. | the chemical synthesis of dna dumbbells is investigated by using two sequences, cyclo-d(gcg-t4-cgccgc-t4-gcg) and cyclo-d(ttcc-t4-ggaattcc-t4-ggaa). this method readily and inexpensively yields multimicromole quantities of circular dna, allowing detailed structural and physical studies to be carried out. linear oligomers of sequence d(gcg-t4-cgccgc-t4-gcg) having either 3'- or 5'-phosphates were cyclized in 40% and 67% isolated yield, respectively, by using 1-[3-(dimethylamino)propyl]-3-ethylcar ... | 1991 | 2007128 |
| [rhinopharyngeal carcinoma. clinical prognostic factors]. | the authors report the results of the retrospective analysis of 306 patients with nasopharyngeal carcinoma. all patients had received high-dose radiation therapy. first, overall results were analyzed, and then the prognostic value of the patients' data (age and sex) and of tumor features (histology, local spread, lymph node involvement). crude actuarial survival rate is 42.9% (+/- 2.9) at 5 years; loco-regional control at the end of treatment was obtained in 16.8% of cases; 53.6% of them (126 pa ... | 1991 | 2006323 |
| dna polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies. | classical genetic selection was combined with site-directed mutagenesis to study bacteriophage t4 dna polymerase 3'----5' exonuclease activity. a mutant dna polymerase with very little (less than or equal to 1%) 3'----5' exonuclease activity was generated. in vivo, the 3'----5' exonuclease-deficient dna polymerase produced the highest level of spontaneous mutation observed in t4, 500- to 1800-fold above that of wild type. the large reduction in 3'----5' exonuclease activity appears to be due to ... | 1991 | 2006180 |
| elevated serum diiodotyrosine (dit) in severe infections and sepsis: dit, a possible new marker of leukocyte activity. | ether link cleavage (elc) of t4 yielding diiodotyrosine (dit) has recently been shown in vitro to be the major pathway of t4 metabolism in phagocytosing leukocytes. to evaluate this pathway in vivo and the possible clinical relevance of dit measurements in diseases with increased leukocyte activity, radioimmunological studies on serum levels of dit and other thyroid parameters were performed in 125 critically ill patients classified into 3 groups with bacterial infections according to the severi ... | 1991 | 2005222 |
| concordant graves' disease after bone marrow transplantation: implications for pathogenesis. | the current working hypothesis on the pathogenesis of autoimmune disease focuses on the interactions between susceptibility genes and environmental stimuli. in graves' disease it is postulated that aberrant expression of hla class ii antigens on thyroid epithelial cells permits the presentation of specific thyroid antigen to activated lymphocytes. evidence suggests that thyrocyte hla-dr expression is secondary to the production of cytokines by presensitized t-lymphocytes. a 20-yr-old woman and h ... | 1991 | 2005210 |
| substitution of basic amino acids within endonuclease v enhances nontarget dna binding. | several dna-interactive proteins, including the dna repair enzyme t4 endonuclease v, have been shown to locate their target recognition sites utilizing an electrostatically mediated facilitated diffusion mechanism. previous work indicates that a decrease in the affinity of endonuclease v for nontarget dna results in an increased nontarget dissociation rate. this study was designed to investigate the effect of an increase in the affinity of endonuclease v for nontarget dna. using a working struct ... | 1991 | 2005104 |
| physiological responses of newborn bos indicus and bos indicus x bos taurus calves after exposure to cold. | brahman (n = 9) and 1/2 simmental x 1/4 brahman x 1/4 hereford (n = 11) calves were utilized to determine the influence of exposure to cold on the physiology of the neonate. all calves were removed from their dams within 20 min of birth and prior to suckling. calves were assigned randomly within breed to either a warm (w; 31 degrees c) or cold (c; 4 degrees c) environmental treatment group. jugular blood samples were collected via indwelling catheters at 20-min intervals for 180 min. at 100 to 1 ... | 1991 | 2005021 |
| segmental spinal fixation of a thoracic vertebral fracture in an adult chimpanzee. | accidental trauma associated with an epileptic convulsion in a 10-year-old, male chimpanzee (pan troglodytes) resulted in incomplete paraplegia from fracture and subluxation of t4. dorsal laminectomy and segmental spinal fixation were used in treatment. the segmental spinal fixation consisted of sublaminar wires attached to a contoured 316l stainless steel u-rod. the chimpanzee recovered sufficient function to allow reintroduction into the chimpanzee colony at a zoological park during the 12 mon ... | 1991 | 2004998 |
| [ultrasonography of the thyroid gland and the pancreas in healthy children and in patients with endocrinological disease]. | the thyroid gland and pancreas were ultrasonographically examined in order to determine their normal sizes in children. in 418 healthy children the thickness and width of the right and left lobes of the thyroid gland were measured at the transverse section of the neck. in 145 healthy children the long axis and short axis diameters of the profile of the head and body of the pancreas were measured by the sagittal scanning at the epigastrium. the mean +/- standard deviations as a function of height ... | 1991 | 2004737 |
| central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. | as judged by the response of uncoupling protein and key enzymes, brown adipose tissue (bat) is highly dependent upon the local generation of t3 catalyzed by the tissue type ii t4 5'-deiodinase (5'-d-ii). in hypothyroid rats treated with t3 or t4, the capacity to withstand cold seems better correlated with the normalization of bat responses than with the liver thyroid status. 5'd-ii is activated by cold via sympathetic nervous system (sns) stimulation, and the activation generates enough t3 to ne ... | 1991 | 2004619 |
| prevalence and follow-up of abnormal thyrotrophin (tsh) concentrations in the elderly in the united kingdom. | increasing use of assays for tsh with improved sensitivity as a first-line test of thyroid function has raised questions regarding prevalence and clinical significance of abnormal results, especially values below normal. we have assessed the thyroid status of 1210 patients aged over 60 registered with a single general practice by measurement of serum tsh using a sensitive assay. high tsh values were more common in females (11.6%) than males (2.9%). tsh values below normal were present in 6.3% of ... | 1991 | 2004476 |
| computerized method for validating laboratory reference ranges for triiodothyronine and thyroxin immunoassays. | we used a computer-based method to help validate the reference ranges of assays for triiodothyronine (t3) and thyroxin (t4). a retrospective search of a database of laboratory results for the previous six months identified all patients with apparent euthyroid status, as defined by methods independent of the immunoassay under review. a computer-generated reference group (cgr group) of 2001 records had a gaussian distribution of t4 values and a reference range (mean +/- 2 sd) of 56-161 nmol/l, com ... | 1991 | 2004453 |
| detection of escherichia coli ribosome binding at translation initiation sites in the absence of trna. | binary complexes between messenger rna and e. coli ribosomes were examined. a ribosome-mrna binary complex on t4 gene 32 mrna withstood inhibition by antibodies against ribosomal protein s1. anti-s1 blocks ternary complex formation, as measured by "extension inhibition" or "toeprinting" analysis, only when preincubated with ribosomes prior to mrna addition and not when anti-s1 was added after preincubation of ribosomes and mrna. the ribosome was directly localized in a binary complex on two tran ... | 1991 | 2002510 |
| induction of 5-deiodinase activity in astroglial cells by 12-o-tetradecanoylphorbol 13-acetate and fibroblast growth factors. | in the brain, 5'-deiodinase (5'-d) is responsible for the metabolic activation of thyroxine (t4) into 3,5,3'-triiodothyronine (t3) and 5-deiodinase (5-d) deiodinates t4 and t3 into inactive metabolites. this study examines the effects of factors known to induce astroglial 5'-d activity on the 5-d activity in cultured rat astroglial cells. the potencies of these factors were compared after 8 h of incubation, when stimulations by these factors near their maximal effects. 12-o-tetradecanoylphorbol ... | 1991 | 2002332 |
| the characterization of a complex of three bacteriophage t4 recombination proteins, uvsx protein, uvsy protein, and gene 32 protein, on single-stranded dna. | three recombination proteins of bacteriophage t4, uvsx, uvsy, and gene 32 proteins, were examined for the formation of a complex with short single-stranded dna (ssdna) molecules containing either 24 or 69 nucleotides. gel-shift assays revealed that either the uvsx or uvsy protein, when present alone, formed a stable complex only with the 69-mer, while the gene 32 protein bound stably to both ssdnas. however, a characteristic stable complex formed on the 24-mer when both the uvsx and uvsy protein ... | 1991 | 2002035 |
| results of radiation therapy in carcinoma of the base of the tongue. the curie institute experience with about 166 cases. | between 1960 and 1980, 166 patients with squamous cell carcinoma of the base of the tongue were treated with primary irradiation at the curie institute (paris, france). distribution according to the tnm system 1978 international union against cancer (uicc) was the following: 22 t1 lesions, 47 t2 lesions, 64 t3 lesions, and 33 t4 lesions. regional nodes were not palpable in 50 cases, 35 had n1 nodes, 12 had n2 nodes, and 69 had n3 nodes. all patients received external beam radiation. the 2-year, ... | 1991 | 2001541 |
| the neuromuscular effects of desflurane, alone and combined with pancuronium or succinylcholine in humans. | the neuromuscular effects of desflurane administered alone were studied in ten healthy human volunteers aged 20-27 yr. also, the dose-response relationships of pancuronium and succinylcholine in surgical patients during anesthesia with desflurane (n = 13) were compared to those during isoflurane anesthesia (n = 14). in the volunteers, we measured the mechanical response of the adductor pollicis muscle to stimulation of the ulnar nerve in a train-of-four (tof) sequence at 2 hz and at tetanic freq ... | 1991 | 2001017 |
| intracellular calcium and phospholipid turnover are not involved in the inhibition of iodothyronine 5'-deiodinase type ii activity by t4. | in glial cell cultures, iodothyronine 5'-deiodinase type ii is stimulated by dibutyryl camp. serum-free medium increases enzyme activity and prolongs the half-life of the enzyme. t4 and rt3 specifically inhibit this activity. we tested whether enzyme inactivation by t4 was mediated by changes in cytosolic free calcium concentration and/or phospholipid turnover. intracellular calcium concentration was decreased either by chelation of extracellular calcium or by chelation of extracellular and intr ... | 1991 | 2000702 |
| the thyroid hormone analogue skf-94901 and iodothyronine binding sites in mammalian tissues: differences in cytoplasmic binding between liver and heart. | the thyroid hormone analogue, skf-94901 exhibits greater thyromimetic activity in the liver than in the heart. this difference in activity may reflect heterogeneity in the affinity of skf-94901 for different forms of the t3 receptor. a difference in extranuclear transport of the analogue could also account for the different response of these two tissues. to distinguish between these possibilities we have examined the binding of skf-94901 to membrane, cytosolic and nuclear preparations from liver ... | 1991 | 2000700 |
| [changes in the thyroid hormone picture that may be found in severely decompensated type ii diabetics]. | thyroid hormone picture of 28 patients (15 males and 13 females), mean age 56.6 yr (range 45-65 yr), with seriously decompensated type ii diabetes mellitus has been studied. in each patient the study was repeated after 3 months of treatment of diabetes. the patients showed significantly lower serum t3 levels and significantly higher serum rt3 levels (p less than 0.001), in comparison with a group of 16 normoglicemic subjects. after 3 months of strict control of diabetes t3 and ft3 significantly ... | 1991 | 2000180 |
| [increase of beta 2-microglobulin in drug addicts with anti-hiv antibodies and high risk of aids]. | the beta 2-microglobulin is a polypeptide present on the surface membrane of both b and t cells and is integrated into the structure of hla antigenes. the beta 2-microglobulin concentration have been used as a reliable indicator of glomerular and tubular function of the kidney. increased serum concentration of beta 2-microglobulin are observed also in lymphoproliferative disorders with high cell proliferation rates. more recently, increased concentration of beta 2-microglobulin was shown in pati ... | 1991 | 2000173 |
| esophageal ultrasound and the preoperative staging of carcinoma of the esophagus. | esophageal ultrasound allows the esophageal wall to be viewed as five discrete layers. lymph nodes are easily identified, and their size, shape, margin, and internal structure can be assessed. this provides an alternative method of preoperative (clinical) evaluation of the primary tumor [t] and the regional lymph nodes [n] of patients with carcinoma of the esophagus. esophageal ultrasound was attempted in the clinical staging of 28 patients with carcinoma of the esophagus. six patients (21%) wer ... | 1991 | 1999948 |
| new assay to detect shedding antigen with use of anti-idiotypic monoclonal antibodies. | anti-idiotypic (anti-id) monoclonal antibodies (moabs) against anti-carcinoembryonic antigen (cea) monoclonal antibody 5b3 (igg1) were prepared and characterized. five anti-id moabs recognized the private idiotype of moab 5b3. idiotype mapping suggested that moab 5b3 had at least three distinct idiotopes at its antigen combining site. utilizing the inhibition of idiotype-anti-idiotype interaction with use of anti-id moab t4-305 or t4-212, an immunoassay to detect shedding cea was established. th ... | 1991 | 1999758 |
| systematic computer-aided search of optimal staging system for colorectal cancer. | two hundred and ninety-eight patients with curatively resected colorectal cancer were classified into 12 categories according to the depth of tumour penetration (t1-t4), and lymph node status (n0-n2). using a computer, these categories were grouped into 2-12 stages in every possible combination, so a total of 146,975 logical classifications were generated. the optimal model was selected for each group of classifications with equal stage number, thus giving the greatest prognostic information on ... | 1991 | 1999688 |
| thyroxine increases epidermal growth factor levels in the mouse thyroid in vivo. | immunoreactive epidermal growth factor (egf) has been detected in the thyroid, which raises questions concerning the source of thyroidal egf and what affects its levels. we therefore have examined the effects of manipulating thyroid function on the immunoreactive egf levels in plasma, thyroid, submaxillary gland (smg), and kidney of adult male balb/c mice, and we also analyzed the prepro-egf messenger rna in these tissues. groups of six mice received daily injection of t4 (1 microgram, 5 microgr ... | 1991 | 1999161 |
| toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in t4 lysozyme. | in an attempt to simplify the protein folding problem, and also to further investigate the role of alanine as a helix-stabilizing residue, a series of alanines was introduced within the alpha-helix that includes residues 126-134 of t4 lysozyme. in wild-type lysozyme this alpha-helix contains alanine residues at positions 129, 130, and 134. mutant lysozymes with alanines substituted at positions 128, 131, 132, and 133, either as single substitutions or in selected combinations, were constructed b ... | 1991 | 1998663 |
| cardiac function in congenital hypothyroidism: impairment and response to l-t4 therapy. | electrocardiograms (heart rate, qrs voltage, qrs axis in the frontal plane. q-tc interval) echocardiograms [left ventricular fractional shortening (lvfs); preejection period (pep); pep/left ventricular ejection time (pep/lvet) ratio; end-diastolic left ventricular free wall and interventricular septum thickness; presence of pericardial effusion], and thyrotropin (tsh), thyroxine (t4), and triiodothyronine (t3) serum levels were evaluated before and 1 week, 1 and 2 months after the start of l-thy ... | 1991 | 1997980 |
| the influence of electrocortical biofeedback on performance in pre-elite archers. | the purpose of the present research was to determine whether eeg biofeedback training could improve archery performance as well as self-reported measures of concentration and self-confidence. experienced pre-elite male (n = 16) and female (n = 8) archers were randomly assigned to one of three treatment conditions: (a) correct feedback (i.e., greater left hemisphere low frequency activity), (b) incorrect feedback (i.e., greater right hemisphere low frequency activity), and (c) no feedback control ... | 1991 | 1997806 |
| effect of iodine deficiency and cold exposure on thyroxine 5'-deiodinase activity in various rat tissues. | we measured thyroxine 5'-deiodinase i (t(4)5'd-i) activity in thyroid, liver, and kidney and thyroxine 5'-deiodinase ii (t(4)5'd-ii) activity in brown adipose tissue (bat) in rats on a low-iodine diet (lid) to test the possibility that increased deiodinase activity in these tissues might contribute to the maintenance of ther serum 3,5,3'-triiodothyronine (t3) level. control rats received lid plus ki. experiments were also performed with lid and lid plus ki rats exposed to cold. t(4)5'd-i activit ... | 1991 | 1996620 |
| [computerized tomography in the planning of radiotherapy of prostatic cancer]. | the paper is devoted to the description of methods of topometric preparation of 73 prostatic cancer patients for gamma-and proton-beam irradiation using an x-ray simulator and a ct tomograph. basing on the measurement of the prostate in 3 directions in patients with different stages of disease (t1-2-24, t3-29 and t4-20), a conclusion was made that a prostate size was not enough to determine a stage of disease though a tendency to an increase in prostate size corresponded to the growing t index. ... | 1991 | 1996064 |
| definitive radiation therapy for localized prostatic adenocarcinoma. | from 1974 to 1987, a total of 199 patients with prostatic carcinoma localized to the pelvis were treated with definitive external beam radiation therapy at the istituto medico e di ricerca scientifica. the median follow-up for all 126 surviving patients was 60 months. actuarial 5-(and 10-) year overall survival rates for u.i.c.c. clinical stage t1-2, t3 and t4 disease were 76.1% (58.5), 66% (42.5), and 27.6%, respectively. the corresponding 5- and 10-) year disease-specific survival rates were 8 ... | 1991 | 1995529 |
| curative radiotherapy following chemotherapy for invasive bladder carcinoma (a preliminary report). | twenty-five patients with invasive transitional cell carcinoma of the bladder (stage t2, t3, t4) received combined modality therapy using four cycles of methotrexate, vinblastine, adriamycin, and cisplatin (mvac) chemotherapy followed by surgery or radiation therapy (rt). sixteen patients had complete (n = 8) or partial (n = 8) response to mvac. curative rt was delivered to 11 responders with t2 or t3 disease and to 2 patients with t4 disease. all 11 with t2 and t3 disease are currently alive, 7 ... | 1991 | 1995525 |
| regulation of rat pancreatic nuclear triiodothyronine receptor by glucocorticoid. | the nuclear t3 receptors in rat pancreas exhibit a characteristic maturation pattern during development and are subjected to autologous regulation by thyroid hormones. to see if glucocorticoids also regulate t3 receptors in the pancreas, rats at various age groups were subjected to experimental conditions that altered their glucocorticoid status and the corresponding changes in nuclear t3 receptors, and exocrine enzymes in their pancreata were evaluated. hydrocortisone administration to normal s ... | 1991 | 1994385 |
| radical radiation treatment of invasive and locally advanced bladder carcinoma in elderly patients. | a total of 146 patients with invasive or locally advanced carcinoma of the bladder (t2-t4) underwent radiation treatment. a significantly higher complete response rate was observed with doses equal to or above 55 gy and with doses corresponding to cumulative radiation effect (cre) values of 1700 radiation effect units (reu) or more. in multivariate analysis, decreasing time from the first diagnosis of bladder carcinoma to radiation treatment and 1 or more transurethral resections was associated ... | 1991 | 1993278 |
| monoclonal antibody-purged autologous bone marrow transplantation therapy for multiple myeloma. | eleven patients with plasma cell dyscrasias underwent high-dose chemoradiotherapy and anti-b-cell monoclonal antibody (moab)-treated autologous bone marrow transplantation (abmt). the majority of patients had advanced durie-salmon stage myeloma at diagnosis, all were pretreated with chemotherapy, and six had received prior radiotherapy. at the time of abmt, all patients demonstrated good performance status with karnofsky score of 80% or greater and had less than 10% marrow tumor cells. eight pat ... | 1991 | 1993214 |
| a differential scanning calorimetric study of the thermal unfolding of seven mutant forms of phage t4 lysozyme. | high-sensitivity differential scanning calorimetry has been applied to the study of the reversible thermal unfolding of the lysozyme of t4 bacteriophage in which the threonine residue at position 157 has been replaced by seven different residues. high-resolution structures derived from x-ray crystallography have been reported for these and six other mutants by alber et al. [alber, t., dao-pin, s., wilson, k., wozniak, j. a., cook, s. p., & matthews, b. w. (1987) nature 330, 41-46]. at ph 2.5 the ... | 1991 | 1993203 |
| serum osteocalcin in patients taking l-thyroxine who have subclinical hyperthyroidism. | serum osteocalcin, an index of osteoblastic activity, is increased in hyperthyroidism. serum osteocalcin levels are negatively correlated with bone density in patients with overt hyperthyroidism. osteocalcin levels are also elevated in patients with multinodular goiter and subclinical hyperthyroidism. we therefore measured serum osteocalcin levels in patients taking t4 to determine if they correlated with the degree of tsh suppression. despite an upward trend in serum osteocalcin measurements wi ... | 1991 | 1991818 |
| evaluation of the antioxidant properties of thyroid hormones and propylthiouracil in the brain-homogenate autoxidation system and in the free radical-mediated oxidation of erythrocyte membranes. | the antioxidant capacity of thyroid hormones and the antithyroid drug propylthiouracil was studied in three model systems, namely, autoxidation of rat brain homogenates and oxidation of rat erythrocyte plasma membranes (epm) induced by either 2,2'-azobis-(2-amidinopropane) (aap) thermolysis or by gamma irradiation. thyroid hormones significantly inhibited the development of lipid peroxidation in these systems at micromolar concentrations, as assessed either by visible light emission, thiobarbitu ... | 1991 | 1991336 |
| predicting recurrence time of esophageal carcinoma through assessment of histologic factors and dna ploidy. | cytophotometric analysis of nuclear dna content was done in 128 patients with squamous cell carcinoma of the esophagus. the relationship among histopathologic features, dna distribution pattern, and survival time was investigated from the standpoint of recurrence. of 128 patients, 77 (60.1%) died of recurrence within 2 years after surgery: 16 (12.5%) from 2 to 5 years and two (1.6%) over 5 years. the rate of death of recurrence within 2 years was higher in patients with t4 or n1 than t1, t2, and ... | 1991 | 1991304 |
| second-site revertants of an inactive t4 lysozyme mutant restore activity by restructuring the active site cleft. | substitution of thr26 by gln in the lysozyme of bacteriophage t4 produces an enzyme with greatly reduced activity but essentially unaltered stability relative to wild type. spontaneous second-site revertants of the mutant were selected genetically; two of them were chosen for structural and biochemical characterization. one revertant bears (in addition to the primary mutation) the substitution tyr18----his, the other, tyr18----asp. the primary mutant and both revertant lysozyme genes were recons ... | 1991 | 1991123 |
| relationship of liver and skeletal muscle igf-1 mrna to plasma gh profile, production of igf-1 by liver, plasma igf-1 concentrations, and growth rates of cattle. | growth hormone (gh), insulin-like growth factor-1 (igf-1), and thyroid hormone (t3 and t4) concentrations in blood plasma of 18 crossbred cattle (six bulls, six steers, and six heifers) were measured over an 8-hr period. one week later at slaughter, igf-1 production by liver slices and igf-1 mrna concentrations in skeletal muscle and liver were measured. bulls had higher (p less than 0.05) mean plasma gh and gh peak amplitudes (p less than 0.01) than heifers, and values for steers were intermedi ... | 1991 | 1990405 |
| location of the active site for enzyme-adenylate formation in dna ligases. | the enzyme-amp reaction intermediate of the 102-kda bovine dna ligase i was digested with trypsin, and the adenylylated peptide was isolated by chromatography under conditions that maintain the acid-labile phosphoramidate bond. microsequencing of the peptide showed that it contains an internal trypsin-resistant lysine residue, as expected for the site of adenylylation. inhibition of dna ligase i activity by pyridoxal 5'-phosphate also indicated the presence of a reactive lysine residue in the ca ... | 1991 | 1988940 |
| stimulation of the processivity of the dna polymerase of bacteriophage t4 by the polymerase accessory proteins. the role of atp hydrolysis. | in this paper we examine the role of the dna polymerase accessory proteins in modulating the processivity of dna synthesis by the bacteriophage t4-coded five protein "holoenzyme" replication complex in vitro. primed single-stranded dna was used as a template for the dna synthesis reactions, and buffer conditions were chosen to mimic in vivo salt concentrations. we find that the accessory proteins significantly increase the dna-bound lifetime of the holoenzyme complex but that the maximum lifetim ... | 1991 | 1988449 |
| processing of dna base damage by dna polymerases. dihydrothymine and beta-ureidoisobutyric acid as models for instructive and noninstructive lesions. | the processing of unrepaired dna lesions is a key to understanding and predicting the biological end points of particular dna damages. in this study, we prepared single-stranded f1 phage (f1-k12) dna containing dihydrothymine or beta-ureidoisobutyric acid as models for instructive or noninstructive base lesions and assessed the potential biological consequences of these lesions in vitro and in vivo. to determine the effect of the two lesions on in vitro dna synthesis, the extent of dna synthesis ... | 1991 | 1988431 |
| a novel combined chemical-enzymatic synthesis of cross-linked dna using a nucleoside triphosphate analogue. | a novel method using combined chemical and enzymatic reactions to allow the preparation of covalently cross-linked dna duplexes has been described. the method can be used to specifically link two complementary bases of a dna duplex containing all four natural bases. the modified nucleotide 9-(2-deoxy-5-o-triphospho-beta-d-ribofuranosyl)-n6,n6-ethano -2,6-diaminopurine (6eddtp) was prepared by total chemical synthesis and was found to be incorporated into dna duplexes in the place of 2'-deoxyguan ... | 1991 | 1988067 |
| correlation between mutational destabilization of phage t4 lysozyme and increased unfolding rates. | the thermodynamics and kinetics of unfolding of 28 bacteriophage t4 lysozyme variants were compared by using urea gradient gel electrophoresis. the mutations studied cause a variety of sequence changes at different residues throughout the polypeptide chain and result in a wide range of thermodynamic stabilities. a striking relationship was observed between the thermodynamic and kinetic effects of the amino acid replacements: all the substitutions that destabilized the native protein by 2 kcal/mo ... | 1991 | 1988046 |
| improved local control of nasopharyngeal carcinoma after intracavitary brachytherapy boost. | in 1976 we began using intracavitary cesium boost technique as a portion of comprehensive treatment of primary t2 and t3 nasopharyngeal carcinoma. at first, we offered this procedure sporadically to patients with t1 lesions. for the past 10 years, intracavitary boost has been offered to all patients except those with t4 lesions. the radiation therapy program consists of external beam dose of 60-64 gy, either once daily (q.d.) or twice daily (b.i.d.) schedule, followed by 10-15 gy boost to mucosa ... | 1991 | 1987739 |
| t cell subsets in the thymus of graft-versus-host immunosuppressed mice. sensitivity of the l3t4+lyt-2- subset to cortisone. | we have investigated the effects of graft-versus-host disease on t cell differentiation in the murine thymus. we previously reported that gvh-induced thymic dysplasia results in a t cell immunodeficiency associated with a lack of il-2 production. this deficiency in il-2 production may be the result of a reduction in the number of l3t4+lyt-2- il-2-producing cells or of a functional defect in this population. to test these two alternatives, flow cytometry analysis of l3t4 and lyt-2 antigen express ... | 1991 | 1987697 |
| the effect of short term feeding of the antioxidant triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate on serum thyrotropin and thyroid hormones in the male rat. | male rats were fed triethyleneglycol-bis-3(3-tert-butyl-4-hydroxy-5-methyl)propionate (tk 12627) admixed with the food at a concentration of 1000 ppm for 3, 6, 13, and 20 days. treatment resulted in time-dependent and marked increases in serum levels of thyrotropin (tsh) and reverse triiodothyronine (rt3). serum levels of thyroxine (t4) were slightly and transiently decreased, whereas triiodothyronine (t3) levels decreased by 35-50% at all time periods. treatment with 50, 150, 500, and 1000 ppm ... | 1991 | 1987652 |
| thyroiditis. acute, subacute, and chronic. | inflammatory diseases of the thyroid are collectively the commonest thyroid disorder. individually, they range from the rare case of acute bacterial thyroiditis to the other end of the spectrum, the even rarer riedel's thyroiditis. relatively common thyroid inflammatory diseases include the subacute thyroiditis syndromes. of particular interest to endocrinologists is that both subacute granulomatous (painful) thyroiditis and subacute lymphocytic (painless) thyroiditis are very similar in terms o ... | 1991 | 1987447 |
| the effects of nonthyroid disease and drugs on thyroid function tests. | serious nonthyroid illness and caloric deprivation, which so often accompany systemic illness, have diverse and still incompletely understood effects on thyroid hormone economy. we have discussed the pathophysiologic basis for the most common pattern of alterations in routine thyroid function tests: a decreased serum t3 concentration; normal or, in critically ill patients, a low total serum t4 level; and a normal free t4 concentration. another, less frequent pattern (high total and free t4 with ... | 1991 | 1987445 |
| thyroid disease and pregnancy. | thyroid disease is common in younger women and may be a factor in reproductive dysfunction. this probably only applies to severe cases of hyper- or hypothyroidism. once adequately treated, neither of these disorders significantly impacts on fertility. the key is to recognize and to treat thyroid disorders in the reproductive-age woman before conception. thyroxine therapy and even antithyroid drug therapy should be continued during pregnancy as necessary. pregnancy is a euthyroid state that is no ... | 1991 | 1987439 |
| effective laboratory evaluation of thyroid status. | this article focuses on recent developments in thyroid-related laboratory tests, including analytical methods, clinical utility, and limitations of tsh, ft4, t4, ft3/t3, thyroglobulin, and thyroid autoantibodies and the effective use of these tests in the diagnosis of various forms of hypothyroidism or hyperthyroidism, and the management of patients undergoing t4 replacement, t4 suppression, or antithyroid drug therapy. | 1991 | 1987438 |
| comparison of toxicity induced by iodine and iodide in male and female rats. | in risk assessments the various forms of iodine have been treated as if they were toxicologically equivalent. while iodide (i-) and iodate (io3-) have been studied, no studies concerned with the subchronic toxicity of iodine (i2) have been conducted in experimental animals. this study examined toxicities associated with iodine. rats were treated with 0, 1, 3, 10, and 100 mg/l of either iodine or iodide (as nal) in the drinking water for 100 d. treatment had no effect on body, brain, or heart wei ... | 1991 | 1987365 |
| lanthanide accumulation in the periplasmic space of escherichia coli b. | treatment of growing escherichia coli b with lanthanide ions [lanthanum(iii), terbium(iii), and europium(iii)] and subsequent aldehyde-oso4 fixation caused areas of high contrast to appear within the periplasm (the space between inner and outer membrane of the cell envelope). x-ray microanalysis of ultrathin sections of epon-embedded or acrylic resin-embedded cells revealed the presence of the lanthanide and of phosphorus in the areas, whose contrast greatly exceeded that of other stained struct ... | 1991 | 1987113 |
| neuroendocrine regulation of adrenal 5'-monodeiodination during acute cold exposure in the rat. i. effects of hypophysectomy. | circulating levels of t4, t3, corticosterone, noradrenaline, and adrenaline, as well as 5'-monodeiodinase activity (5'-ma) were measured in control and hypophysectomized rats acutely exposed to cold environment (15-120 min, 4 c). in addition to the well known activation of the sympathoadrenomedullary system and the hypothalamic-pituitary-adrenal and-thyroid axes, cold exposure was followed by a rapid and sustained increase of 5'-ma in the hypothalamus, and a byphasic course of activation in the ... | 1991 | 1986942 |
| thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism. | having previously observed that t4 and t3 levels in fetal rat brain and brown adipose tissue are clearly higher than expected from their low circulating levels, we have now studied thyroid hormone concentrations and 5'-deiodinase activities (5'd) in several other rat fetal tissues during the last 6 days of gestation (dg), namely 17-22 dg. this period comprises the onset of fetal thyroid activity. total thyroidal t4 and t3 contents increased 100- and 400-fold, respectively; t4 concentrations incr ... | 1991 | 1986934 |
| the effect of surgical stress on the in vitro metabolism of thyroxine by rat liver, kidney, and brain. | in man, acute stress, like extensive surgery, leads to a rapid and prolonged decrease in serum t3 concentrations. the present study was carried out to investigate the mechanisms that underly the abrupt decrease in t3-neogenesis that occurs in response to acute surgical stress. male sprague-dawley rats, surgically thyroidectomized, and treated with 1.2 micrograms t4/100 g bw/day, underwent wide vertical and horizontal incisions extending into the abdominal cavity while receiving light ether anest ... | 1991 | 1986915 |
| thyroid function in a healthy elderly population: implications for clinical evaluation. | evaluation of thyroid function in elderly people is complex and has generated some controversy about what is normal. this study analyzed thyroid function assays in an identified healthy elderly population of 216 subjects. thyroxine, free thyroxine, triiodothyronine, t3 uptake, "supersensitive" thyrotropin, and thyroid antibody titers were performed. histories of treatment for thyroid conditions were present in 13.9% (n = 30) of the population, and test results for an additional 4.3% (n = 8) reve ... | 1991 | 1986034 |
| pulsatile thyrotropin release and thyroid function in acromegalics before and during subcutaneous octreotide infusion. | the pulsatile secretion of tsh was studied in eight patients with active acromegaly before treatment and after 1 month of therapy consisting of the sc infusion of 300 micrograms octreotide/day. mean gh levels decreased from 37.1 +/- 7.2 to 5.2 +/- 1.4 mu/l (p = 0.002). insulin-like growth factor-i levels decreased from 82.9 +/- 8.8 to 37.8 +/- 9.8 nmol/l (p less than 0.01) and normalized in five of the eight patients. in one patient tsh levels were undetectable before and during octreotide thera ... | 1991 | 1986030 |
| influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. | to determine the influence of prolonged fasting and refeeding on rt3 metabolism in man, five euthyroid obese subjects underwent a 13-day fast, followed by a refeeding period. each patient received an iv dose of 25 muci [125i]rt3 during the fed control period, on days 7 and 13 of the fast, and on the fourth day after refeeding with a regular diet. serial blood and urine samples were obtained to determine serum rt3 clearance and production rates and the urinary tracer rt3 deiodination fraction. si ... | 1991 | 1986011 |
| low serum thyrotropin (thyroid-stimulating hormone) in older persons without hyperthyroidism. | we studied a large population (n = 2575) of unselected ambulatory persons older than 60 years to determine the prevalence of a low serum thyroid-stimulating hormone (tsh) level, ie, of less than 0.1 mu/l using a sensitive assay, a level suggestive of hyperthyroidism in younger adults. one hundred one persons (3.9%) had a low serum tsh level. about half of them (51/101) were taking thyroid hormone. of the remainder, 44 were not hyperthyroid did not become so during up to 4 years of follow-up. for ... | 1991 | 1985591 |
| an increase in plasma cholesterol independent of thyroid function during long-term amiodarone therapy. a dose-dependent relationship. | to determine whether long-term amiodarone treatment is associated with a rise in plasma cholesterol, and, if so, to analyze its relation with thyroid function. | 1991 | 1984387 |
| 32p-postlabeling of n-7, n2 and o6 2'-deoxyguanosine 3'-monophosphate adducts of styrene oxide. | adducts were prepared by reacting styrene oxide with 2-deoxyguanosine 3'-monophosphate (dgmp). four isomeric n-7-, two diastereomeric n2- and three isomeric o6-adduct were isolated and characterized. the adducts were used as substrates in the 32p-postlabeling reaction. no phosphorylation products were seen with the n-7-alkylation products. one diastereomeric n2-adduct was labeled with 20% efficiency and the second with a markedly lower efficiency. two of the three o6-adducts were labeled with 5% ... | 1991 | 1983964 |
| [current status of surgical therapy concepts with curative intent in esophageal cancer]. | curative surgical treatment of esophageal cancer involves the complete macroscopic and microscopic removal of the tumor (r0-resection), since this is the only means by which the prognosis can be improved. the treatment of choice for squamous cell cancer is transthoracic en bloc esophagectomy. tumors penetrating the esophageal wall (t3/t4) above the tracheal bifurcation and t4 tumors below the bifurcation should be treated preoperatively by (radio)chemotherapy within the framework of a multimodal ... | 1990 | 1983693 |
| [bronchial cancer: radiation therapy]. | postoperative radiotherapy as a routine procedure has failed to show any benefit in prospective randomized studies. local failure was diminished, but survival rates remained unchanged, probably because of radiation complications. by improvement of radiation techniques, however, reduction of single doses and total dose and focusing postoperative irradiation of lung cancer to high risk cases (n2, t4) survival rates with postoperative irradiation are about 20% after 5 years. the results of 191 trea ... | 1990 | 1983685 |
| [partial resection of primary liver cell cancer]. | between 1985 and 1990, 47 patients with primary hepatocellular carcinoma (hcc) underwent surgery (n = 27), chemoembolization (n = 12) or palliative resection followed by chemoembolization (n = 5). in 85% of the patients a t3/t4 tumor stage was found, 68% had liver cirrhosis and 42% were older than 70. mortality was 18.7% after liver resection and 0% after chemoembolization or combined treatment. average survival was 4.4 months after chemoembolization, 11.6 months after resection and 11.6 months ... | 1990 | 1983546 |
| evidence for susceptibility of intrathymic t cell precursors to human immunodeficiency virus infection: a mechanism for t4 (cd4) lymphocyte depletion. | 1990 | 1983432 | |
| follow-up study of thyroid stimulating-blocking antibodies in hypothyroid patients. | it has been shown that hypothyroidism of some patients may be associated with increased activity of thyroid stimulating-blocking antibodies (tsbab). the present study was undertaken to follow the course of thyroid blocking, stimulating immunoglobulins and tsh-binding inhibitor immunoglobulins (tbii) in six hypothyroid patients who had elevated tsbab and were treated with t4. four of the six had graves' disease previously treated with antithyroidal drugs, one had graves' disease treated with 131i ... | 1990 | 1982862 |
| fanconi syndrome: report of a case. | a 59-year-old female patient was admitted because of muscle weakness in all four limbs for a period of 5 days. she had been found to have graves' disease 4 years ago previous to this, and had received a subtotal thyroidectomy 1 year later. hypothyroidism supervened and she had been receiving levothyroxine replacement in recent years. she also had non-insulin-dependent diabetes, which was controlled with diet only. during the 5 days prior to admission, she developed muscle weakness which finally ... | 1990 | 1982686 |
| sonographic presentation in autoimmune thyroiditis. | we used real-time ultrasonography to examine 60 patients with autoimmune thyroiditis, then correlated the ultrasonic pictures with thyroid function, thyroid autoantibodies and fine needle aspiration cytology. in these 60 patients, 45 (75%) showed diffuse goiter, 6 (10%) showed multinodular goiter, and 9 (15%) had a solitary thyroid nodule sonographically. one of the 9 patients with a solitary nodule was a case of autoimmune thyroiditis combined with papillary carcinoma. the echogenicity of the t ... | 1990 | 1982673 |
| [lymphocyte phenotypes and their correlation with clinical features in systemic lupus erythematosus (sle)]. | lymphocyte phenotypes of peripheral blood from 32 sle patients and 30 normal subjects were studied with 13 kinds of monoclonal antibodies using indirect immunofluorescence technique. the results showed that t4+, t8+, t3+ and t11+ cells decreased in active cases of sle, while ia+, il2r1+ and pca-1+ cells increased, other b-cell phenotypes (b1, b2, b4, igm, igg, igd) showed no significant difference from those of the normal group. thus, in inactive sle after therapeutic management, the numbers of ... | 1990 | 1982646 |
| immunological abnormalities in family members of patients with iga nephropathy. | we examined several immunological parameters such as the number of t cells with cd4 antigen and the receptor for the fc portion of iga (t alpha cells), in vitro immunoglobulin production by peripheral blood lymphocytes with or without pokeweed mitogen and serum levels of immune complexes in 19 healthy family members of patients with iga nephropathy (igan). it was shown that the levels of serum iga, t4 cells, cd4/cd8 ratio of t cell subsets, t alpha cells, iga circulating immune-complexes and spo ... | 1990 | 1982451 |
| [the relationship between il-2 production and t cell subpopulation in patients with systemic lupus erythematosus]. | the authors reported il-2 production and t cell subpopulation of peripheral blood lymphocytes from patients with systemic lupus erythematosus(sle). the results indicated that patients with sle showed a decreased il-2 production and a decreased t4/t8 cell ratio. the relation between il-2 production and t4/t8 ratio was also observed. our data suggest that il-2 production correlates significantly with t4/t8 cell ratio. | 1990 | 1982255 |
| [determination of lymphocyte subsets in pulmonary tuberculosis by mc-ab- rosette reagent method]. | the lymphocyte subsets in peripheral blood were determined in 73 cases of active pulmonary tuberculosis and 40 healthy subjects using rosette reagent of monoclonal antibody (mcab) to anti-t lymphocyte. the results showed that the percentages of t3, t4, t8, and t4/t8 ratio were 54.3 +/- 6.7%, 34.3 +/- 7.9%, 35.5 +/- 10.0%, 1.0 +/- 0.4 of patients group 66.3 +/- 7.9%, 45.3 +/- 6.3%, 29.9 +/- 5.8% and 1.6 +/- 0.3 of healthy control group respectively. there was statistically significant difference ... | 1990 | 1982248 |
| modulation of gamma-glutamyltranspeptidase activity in rat liver plasma membranes by thyroid hormone. | 1. in adult male and female rats, liver plasma membrane gamma-glutamyltranspeptidase activities were 16-fold higher in the propylthiouracil (ptu)-induced hypothyroid state than in the control euthyroid state; thyroxine (t4)-replacement resulted in an 80% restoration to control levels. 2. liver plasma membrane gamma-glutamyltranspeptidase activities were 6.7-fold higher in ptu-induced congenitally hypothyroid rats than in control euthyroid rats; t4-replacement reduced enzyme activities to 37% of ... | 1990 | 1980896 |
| in vivo biliary excretion and in vitro cellular accumulation of thyroxine by rats or cultured rat hepatocytes treated with a novel histamine h1-receptor antagonist. | rats treated with temelastine (sk&f 93,944), a novel histamine h1-receptor antagonist, develop thyroid lesions characterized by hypertrophy and colloid depletion. to investigate the mechanism underlying the lesion the biliary clearance and hepatocellular accumulation of radio-labelled iodothyronines was measured in rats or cultured rat hepatocytes. treatment with temelastine increased both the biliary clearance (approximately 300% of control) and hepatocellular accumulation (approximately 200%) ... | 1990 | 1980408 |
| the age at onset of diabetes influences functional and structural changes in the pituitary-thyroid axis of streptozocin-diabetic male rats. | severe structural changes leading to marked alterations in secretory activity are known to occur in the pituitary-thyroid axis 1 month after induction of postpuberal streptozocin (sz)-diabetes. however, sz-diabetic rats of different age groups have not been compared, nor has the maturity of the pituitary and thyroid glands at the onset of diabetes been correlated with the type and evolution of functional and structural changes. we thus induced diabetes in 1-month (prepuberal of 3-month (postpube ... | 1990 | 1980170 |
| targeting of antiviral drugs to t4-lymphocytes. anti-hiv activity of neoglycoprotein-aztmp conjugates in vitro. | the delivery of the anti-hiv agent 3'-azido-3'-deoxythymidine (azt), in its 5'-monophosphate form, (in) to human t-lymphocyte mt-4 cells in vitro through covalent coupling to neoglycoproteins was investigated. in vivo application of this drug targeting concept may lead to increased efficacy and/or diminished side effects caused by azt during the treatment of aids and arc patients. the rationale for the design of the neoglycoprotein carriers is based on the existence of sugar recognizing lectins ... | 1990 | 1979734 |
| a point mutation in transthyretin increases affinity for thyroxine and produces euthyroid hyperthyroxinemia. | in a family expressing euthyroid hyperthyroxinemia, an increased association of plasma thyroxine (t4) with transthyretin (ttr) is transmitted by autosomal dominant inheritance and is secondary to a mutant ttr molecule with increased affinity for t4. eight individuals spanning three generations exhibited the abnormality. although five of eight individuals had elevated total t4 concentrations, all affected individuals were clinically euthyroid and all had normal free t4 levels. purified ttr from t ... | 1990 | 1979335 |
| a novel membrane-bound serine esterase in human t4+ lymphocytes immunologically reactive with antibody inhibiting syncytia induced by hiv-1. purification and characterization. | a novel membrane-bound serine esterase, named tryptase tl2, which is immunologically reactive with the antibody inhibiting induction of syncytia by human immunodeficiency virus-1 (hiv-1) (hattori, t., koito, a., takatsuki, k., kido, h., and kutunuma, n. (1989) febs lett., 248, 48-52), has been purified from a human t4+ lymphocyte clone. the enzyme has a molecular mass of 198 +/- 15 kda, as judged by gel-permeation liquid chromatography, and is composed of two subunits of 32 kda and four subunits ... | 1990 | 1979328 |
| interaction of sevoflurane, isoflurane, enflurane and halothane with non-depolarizing muscle relaxants and their prejunctional effects at the neuromuscular junction. | the interaction of four inhalational anesthetics (sevoflurane, isoflurane, enflurane and halothane) with pancuronium and vecuronium and also their prejunctional actions at the neuromuscular junction were quantitatively studied using rat phrenic nerve-hemidiaphragm preparations. to investigate the prejunctional effects of inhalational anesthetics, a train-of-four ratio (t4/t1) and the tetanus ratio (the ratio of the final response to the initial response during tetanus) were evaluated. all four i ... | 1990 | 1978766 |
| high-dose intravenous immunoglobulins in hiv-1-infected adults with aids-related complex and walter-reed 5. | the influence of high-dose intravenous immunoglobulins (hd-ivig) on the clinical status and t4 cell count of adults with aids-related complex (arc) and walter-reed 5 (wr5) was evaluated in a randomized double-blind longitudinal study. inclusion criteria were: (1) t4 cells less than 400/microliters and (2a) oral thrush or cutaneous anergy or (2b) two clinical arc criteria (fever, diarrhea, weight loss, fatigue, night sweats). thirty patients [28 males, 2 females, median age 41 (24-64) years] with ... | 1990 | 1978443 |
| production of a non-functional nef protein in human immunodeficiency virus type 1-infected cem cells. | the nef gene product of the human immunodeficiency virus (hiv) is suggested to be a negative factor involved in down-regulating viral expression by a mechanism in which the correct conformation of the nef protein is essential. the nef protein expressed by vaccinia virus recombinants is phosphorylated by protein kinase c. we investigated the synthesis of the nef protein and its state of phosphorylation during hiv-1 infection of a t4 cell line (cem cells). maximum synthesis of viral proteins occur ... | 1990 | 1977871 |
| using a computerized method to measure 99mtc pertechnetate uptake for the assessment of thyroid function: a clinical validation. | this retrospective study evaluated thyroid function by the 99mtc pertechnetate uptake ratio, using computer software designed in our laboratory. we expected that this measurement could be a precise and accurate index. the following studies were performed on 187 patients: (1) 24-hour radioimmunoassay of serum thyroid hormones, including serum thyroxine, free t4, triiodothyronine, thyrotropin concentrations, and t3 resin uptake; (2) 99mtc pertechnetate thyroid imaging and uptake measurement; and ( ... | 1990 | 1977844 |
| beta blockers induce different intrarenal effects in humans: demonstration by selective infusion of tertatolol and propranolol. | the effects of tertatolol and propranolol on renal circulation were studied in patients with normal renal function to test the hypothesis that various beta blockers may have different vasomotor effects within the renal vascular bed. left renal blood flow was measured by the continuous thermodilution method before (t0), and 5 (t1), 10 (t2), 20 (t3), and 30 (t4) minutes after a selective infusion of tertatolol (0.25 mg, n = 4) or propranolol (2.5 mg, n = 4) into the left renal artery. heart rate, ... | 1990 | 1977772 |
| thyroid stimulating hormone receptor antibody in thyroid diseases. | thyroid stimulating hormone receptor antibody (tra) was estimated as a measure of tsh binding inhibitory immunoglobulin (tbii) in 48 persons. these included (i) 14 controls; (ii) 23 patients with graves' disease who were tested for tra within 3 months of commencing treatment with carbimazole of which 13 were studied serially; (iii) 5 patients with toxic nodular goitre; (iv) 4 with euthyroid exophthalmos; and (v) 2 neonates of thyrotoxic mothers. tra was measured with an ria system, while total t ... | 1990 | 1977696 |
| regulatory role of microfilaments in the induction of t4 cell proliferation and interleukin 2 production. | the role of microfilaments in human t4 cell proliferation and lymphokine production triggered via various pathways of activation was examined by investigating the effects of cytochalasins on these responses. the data demonstrate that the effects of cytochalasins vary depending on the nature of the stimulus and on the concentration of the cytochalasin. concentrations of cytochalasin that would be expected to bind both the low and high affinity binding sites (5-20 microm), that represent cytosolic ... | 1990 | 1977524 |
| immunohistochemical study of oral lesions of lichen planus: diagnostic and pathophysiologic aspects. | the immunophenotype of lymphoid cells in the epithelium and lamina propria of the oral mucosa were examined in patients with lichen planus, nondysplastic leukoplakia, leukoplakia with lichen planus, and other unrelated lesions. in all groups t lymphocytes were predominant; however, the t4/t8 lymphocyte ratio was higher with lichen planus than with other groups. this may be of diagnostic value in the histologic evaluation of oral lesions not typical of lichen planus. finally, a higher percentage ... | 1990 | 1977114 |
| ["t" lymphocytes. their role in periodontal disease]. | the immune response is now proved to be of great importance in the control of periodontal diseases. the predominant role of t lymphocytes in the mechanisms of specific immunity is admitted and is related to the functions of effectors t cells and t-helper cells, controlling the response of macrophages and the antibody production. the relations between the evolution of the disease and the tissular t/b and t4/t8 ratio and the lymphocyte function tests are discussed. | 1990 | 1976796 |
| sensitivity of treponemal tests for detecting prior treated syphilis during human immunodeficiency virus infection. | to evaluate the sensitivity of treponemal tests as a marker of prior syphilis in individuals with human immunodeficiency virus (hiv) infection, the syphilis serology of 109 homosexual men with a documented history of treated syphilis was compared with records of prior results and confirmed on stored serum samples. none of the hiv-seronegative individuals lost reactivity to a treponemal test, whereas 7% of the seropositive asymptomatic individuals and 38% of those with symptomatic hiv infection h ... | 1990 | 1976130 |
| the occurrence of thyrotropin binding-inhibiting immunoglobulins and thyroid-stimulating antibodies in patients with silent thyroiditis. | silent (painless) thyroiditis has been recognized as a clinical entity for over a decade and is characterized by spontaneously resolving thyrotoxicosis. its etiology is uncertain; however, a few reports have indicated the occurrence of tsh binding-inhibiting immunoglobulins (tbii) and thyroid-stimulating antibodies (tsab) in some of the patients. the present study was undertaken to evaluate thyroid function and the occurrence of tbii and tsab and thyroid autoantibodies (antithyroglobulin and ant ... | 1990 | 1976125 |
| thermogenic effect of thyroid hormones: interactions with epinephrine and insulin. | the interactions between thyroid hormones, epinephrine, and insulin in the regulation of energy expenditure were investigated in a group of healthy young men before and after thyroxine (t4) treatment (300 micrograms/day for 14 days) at basal plasma insulin concentrations and during hypoinsulinemia with and without epinephrine infusion (0.05 micrograms.kg fat-free mass-1.min-1). t4 treatment induced moderate hyperthyroidism and increased resting energy expenditure (rmr). the effect was more prono ... | 1990 | 1975987 |