Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| azole resistance in aspergillus fumigatus isolates from the artemis global surveillance study is primarily due to the tr/l98h mutation in the cyp51a gene. | we surveyed 497 isolates of aspergillus fumigatus collected from 2008 to 2009 as part of the artemis global surveillance study for elevated mic values to itraconazole, voriconazole, and posaconazole. sequencing of the cyp51a gene revealed that 8/29 isolates with elevated mic values to one or more triazoles, all originating in china, contained the tr/l98h mutation associated with resistant european isolates of a. fumigatus. this is the first time the tr/l98h mutation has been identified outside e ... | 2011 | 21690285 |
| fungi isolated from olive ecosystems and screening of their potential biotechnological use. | this study investigated the fungi diversity of fresh olive (olea europaea l.) fruits, olive paste (crushed olives) and olive pomace (solid waste) and screened and quantified enzymatic activities with biotechnological applications. fungi were randomly isolated from olive cultivars from castilla la mancha region (spain). identification included comparison of their polymerase chain reaction (pcr) amplicons of the its1-5.8s-its2 ribosomal dna region, followed by nucleotide sequence analysis. fourtee ... | 2011 | 21689797 |
| volatile organic compounds and bioaerosols in the vicinity of a municipal waste organic fraction treatment plant. human health risks. | purpose: the aim of this study was to analyze air concentrations of chemical and microbiological pollutants in the vicinity of an organic waste treatment plant, ecoparc-2, located in montcada i reixac (catalonia, spain), as well as to determine the seasonal trends. the human health risks due to the presence of those agents were also assessed. methods: air samples were collected at different distances and wind directions from the ecoparc-2 in two campaigns (winter and summer of 2010). the levels ... | 2011 | 21688069 |
| intravitreal voriconazole as primary treatment for endogenous aspergillus endophthalmitis. | this report describes the first case of aspergillus endophthalmitis after heart transplantation which was successfully treated with intravitreal voriconazole. a 62-year-old man receiving immunosuppressive agents after a heart transplant presented with pain, reduced visual acuity and redness of the left eye. the patient had been diagnosed with invasive pulmonary aspergillosis and was being treated with intravenous voriconazole. endogenous endophthalmitis was diagnosed. aspergillus fumigatus was i ... | 2009 | 21687050 |
| induction of mucin and muc5ac expression by the protease activity of aspergillus fumigatus in airway epithelial cells. | allergic bronchopulmonary mycosis, characterized by excessive mucus secretion, airflow limitation, bronchiectasis, and peripheral blood eosinophilia, is predominantly caused by a fungal pathogen, aspergillus fumigatus. using dna microarray analysis of nci-h292 cells, a human bronchial epithelial cell line, stimulated with fungal extracts from a. fumigatus, alternaria alternata, or penicillium notatum, we identified a mucin-related muc5ac as one of the genes, the expression of which was selective ... | 2011 | 21685325 |
| posaconazole: a new antifungal weapon. | the last twenty years, the incidence of invasive fungal infections (ifi) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections. amphotericin b was for more than 40 years the gold standard for almost all ifi, but toxicity and resistance, especially of new and emerging pathogens remained important issues. fluconazole and itraconazole have also the same disadvantage of resistance. voriconazole, a new triazole antifungal has offered a ... | 2011 | 21682687 |
| detection of aspergillus species on bactec blood cultures. | invasive aspergillosis is associated with high morbidity and mortality rates; nevertheless, blood cultures invariably yield a negative result. the recovery and detection time of aspergillus fumigatus, aspergillus flavus, and aspergillus terreus were studied in bactec plus aerobic/f, mycosis-ic/f, and myco/f lytic vials, incubated in the bactec 9240 and 9000 mb automated systems. two different approaches were used for subculture in solid medium: i) the routine method, using a sterile airway needl ... | 2011 | 21680767 |
| antimicrobial sesquiterpenoids from laurus nobilis l. | activity-guided fractionations of leaf extracts from laurus nobilis l. led to the isolation of a known sesquiterpene lactone, deacetyl laurenobiolide (1). compound 1 showed antimicrobial activity against periopathic pathogens (actinomyces viscosus, porphyromonas gingivalis, prevotella intermedia and actinobacillus actinomycetemcomitans), opportunistic gram-positive bacteria (staphylococcus aureus and streptococcus pyogenes) and fungi (candida albicans, cryptococcus neoformans and aspergillus fum ... | 2011 | 21678158 |
| direct observation of phagocytosis and net-formation by neutrophils in infected lungs using 2-photon microscopy. | after the gastrointestinal tract, the lung is the second largest surface for interaction between the vertebrate body and the environment. here, an effective gas exchange must be maintained, while at the same time avoiding infection by the multiple pathogens that are inhaled during normal breathing. to achieve this, a superb set of defense strategies combining humoral and cellular immune mechanisms exists. one of the most effective measures for acute defense of the lung is the recruitment of neut ... | 2011 | 21673640 |
| epidemiological trends in invasive aspergillosis in france: the saif network (2005-2007). | clin microbiol infect abstract: a prospective (2005-2007) hospital-based multicentre surveillance of eortc/msg-proven or probable invasive aspergillosis (ia) cases whatever the underlying diseases was implemented in 12 french academic hospitals. admissions per hospital and transplantation procedures were obtained. cox regression models were used to determine risk factors associated with the 12-week overall mortality. with 424 case-patients included, the median incidence/hospital was 0.271/10(3) ... | 2011 | 21668573 |
| detection of characteristic metabolites of aspergillus fumigatus and candida species using ion mobility spectrometry - metabolic profiling by volatile organic compounds. | volatile metabolites of aspergillus fumigatus and candida species can be detected by gas chromatography/mass spectrometry (gc/ms). a multi-capillary column - ion mobility spectrometer (mcc-ims) was used in this study to assess volatile organic compounds (vocs) in the headspace above a. fumigatus and the four candida species candida albicans, candida parapsilosis, candida glabrata and candida tropicalis in an innovative approach, validated for a. fumigatus and c. albicans by gc/ms analyses. for t ... | 2011 | 21668516 |
| induced production of n-formyl alkaloids from aspergillus fumigatus by co-culture with streptomyces peucetius. | co-culture of the fungus aspergillus fumigatus with the bacteria streptomyces peucetius led to the induction of production of formyl xanthocillin analogues. this mixed fermentation yielded two new metabolites, fumiformamide (1) and n,n'-((1z,3z)-1,4-bis(4-methoxyphenyl)buta-1,3-diene-2,3-diyl)diformamide (2), together with two known n-formyl derivatives and the xanthocillin analogue bu-4704. the structures were determined by spectroscopic methods and by comparison with literature. cytotoxic acti ... | 2011 | 21667925 |
| complete nucleotide sequences of two dsrnas associated with a new partitivirus infecting aspergillus fumigatus. | 2011 | 21667286 | |
| immune responses against aspergillus fumigatus: what have we learned? | aspergillus fumigatus causes invasive and allergenic disease. host defense relies on the ability of the respiratory immune system to restrict spore germination into invasive hyphae and to limit fungus-induced or inflammation-induced damage in infected tissues. this review covers the molecular and cellular events that mediate innate and cd4 t-cell responses to a. fumigatus and fungal attributes that counter hostile microenvironments and, in turn, affect host responses. | 2011 | 21666456 |
| secretome analysis of aspergillus fumigatus reveals asp-hemolysin as a major secreted protein. | surface-associated and secreted proteins represent primarily exposed components of aspergillus fumigatus during host infection. several secreted proteins are known to be involved in defense mechanisms or immune evasion, thus, probably contributing to pathogenicity. furthermore, several secreted antigens were identified as possible biomarkers for the verification of diseases caused by aspergillus species. nevertheless, there is only limited knowledge about the composition of the secretome and abo ... | 2011 | 21658997 |
| dual organism transcriptomics of airway epithelial cells interacting with conidia of aspergillus fumigatus. | given the complex nature of the responses that can occur in host-pathogen interactions, dual transcriptomics offers a powerful method of elucidating these interactions during infection. the gene expression patterns of aspergillus fumigatus conidia or host cells have been reported in a number of previous studies, but each focused on only one of the interacting organisms. in the present study, we profiled simultaneously the transcriptional response of both a. fumigatus and human airway epithelial ... | 2011 | 21655222 |
| synthesis of 4-hydroxycoumarin heteroarylhybrids as potential antimicrobial agents. | a new series of 4-hydroxycoumarin derivatives 3a-d was synthesized by the reaction of 3-bromo-4-hydroxy coumarin 1 with various heteroaldehydes 2a-d in good yields. the synthesized compounds were characterized on the basis of their elemental and spectral (ir, (1) h-nmr and mass spectrometry) analysis. all target compounds were evaluated for their in-vitro antimicrobial activity against streptococcus pyogenes, methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumon ... | 2011 | 21647940 |
| toll-like receptor 2 sirna suppresses corneal inflammation and attenuates aspergillus fumigatus keratitis in rats. | toll-like receptors (tlrs) are key components of innate immunity that detect microbial infection and trigger host defense responses. however, they are capable of initiating both protective and damaging immune responses, as exaggerated expression of inflammatory components can have devastating effects on the host. we previously reported that tlr2 in corneal epithelium has an important role in the pathogenesis of fungal keratitis, however, how the corneal inflammation is modulated remains to be el ... | 2011 | 21647173 |
| regulatory circuitry governing fungal development, drug resistance, and disease. | summary: pathogenic fungi have become a leading cause of human mortality due to the increasing frequency of fungal infections in immunocompromised populations and the limited armamentarium of clinically useful antifungal drugs. candida albicans, cryptococcus neoformans, and aspergillus fumigatus are the leading causes of opportunistic fungal infections. in these diverse pathogenic fungi, complex signal transduction cascades are critical for sensing environmental changes and mediating appropriate ... | 2011 | 21646428 |
| [investigation of interleukin-10, tumor necrosis factor-alpha and interferon-gamma expression in experimental model of pulmonary aspergillosis.] | pulmonary aspergillosis which is an important opportunistic infection in neutropenic patients, is usually caused by aspergillus fumigatus. since the pathogenesis of disease is not well understood, the main proposed mechanism is thought to be cell-mediated immunity and cytokine response. the aim of this study was to investigate the local production of cytokines in the lung tissues of rats with experimentally developed aspergillosis, by reverse transcriptase-polymerase chain reaction (rt-pcr). a t ... | 2011 | 21644078 |
| [evaluation of the significance of molecular methods in the diagnosis of invasive fungal infections: comparison with conventional methods.] | direct microscopy and culture methods are still valuable standard conventional methods for the diagnosis of infections caused by true or opportunistic fungal pathogens, especially in high risk patients. however, some of the problems concerning the application and interpretation of those methods, indicate a need for more rapid, practical and reliable tests with high sensitivity and specificity. this study was conducted to compare the results obtained by molecular methods with the results of conve ... | 2011 | 21644076 |
| generation of a multiple pathogen-specfic t-cell product for adoptive immunotherapy based on activation-dependent expression of cd154. | viral and fungal infections remain a leading cause of mortality in patients after hematopoietic stem cell transplantation (hsct). adoptive transfer of multi-pathogen-specific t cells is promising in restoring immunity and thereby preventing and treating infections, but approaches are currently limited due to time-consuming and laborious procedures. therefore, we investigated a new strategy to simultaneously select t cells specific for viral and fungal pathogens based on activation-dependent expr ... | 2011 | 21642594 |
| fungal allergen {beta}-glucans trigger p38 mapk-mediated il-6 translation in lung epithelial cells. | in addition to the immune cells, airway epithelial cells can contribute and shape the immune response in the lung by secreting specific cytokines. il-6 is a key factor in determining the effector fate of cd4+ t cells. here we show that under basal conditions the il-6 gene is already highly expressed in lung epithelial cells, but not in immune cells resident in the lung. however, upon lung exposure to fungal allergens, the direct contact of the beta-glucans present in the fungus cell wall with lu ... | 2011 | 21642586 |
| targeting st2l potentiates cpg-mediated therapeutic effects in a chronic fungal asthma model. | il-33 and its soluble receptor and cell-associated receptor (st2l) are all increased in clinical and experimental asthma. the present study addressed the hypothesis that st2l impairs the therapeutic effects of cpg in a fungal model of asthma. c57bl/6 mice were sensitized to aspergillus fumigatus and challenged via i.t. instillation with live a. fumigatus conidia. mice were treated with igg alone, anti-st2l monoclonal antibody (mab) alone, cpg alone, igg plus cpg, or anti-st2l mab plus cpg every ... | 2011 | 21640974 |
| annexin c4 in a. fumigatus: a proteomics approach to understand the function. | annexin c4 has been identified as a new member of fungal annexin family. in search of function, we have generated an annexin c4 disruptant strain of human pathogen, aspergillus fumigatus. detailed phenotypic analysis confirmed a non essential role of annexin c4 in the growth and sporulation of this pathogen. we applied a comparative proteomics strategy to understand the possible role of this protein in the fungus. the modification of respiratory chain proteins and stress response proteins sugges ... | 2011 | 21640208 |
| human lysozyme has fungicidal activity against nasal fungi. | background: the cationic antimicrobial peptide lysozyme is the most prevalent innate immune protein in nasal secretions but there is a paucity of research regarding its role in paranasal sinus disease. lysozyme is generally regarded as an antibacterial agent; however, some data suggest activity toward yeast. this study was designed to determine if lysozyme displays fungicidal activity toward fungi commonly identified in patients with chronic rhinosinusitis (crs) orfungal sinusitis.methods: using ... | 2011 | 21639997 |
| mouldy feed, mycotoxins and shiga toxin - producing escherichia coli colonization associated with jejunal hemorrhage syndrome in beef cattle. | abstract: background: both o157 and non-o157 shiga toxin - producing escherichia coli (stecs) cause serious human disease outbreaks through the consumption of contaminated foods. cattle are considered the main reservoir but it is unclear how stecs affect mature animals. neonatal calves are the susceptible age class for stec infections causing severe enteritis. in an earlier study, we determined that mycotoxins and stecs were part of the disease complex for dairy cattle with jejunal hemorrhage sy ... | 2011 | 21639911 |
| cytotoxicity of aspergillus fungi isolated from hospital environment. | the majority of mycotoxins produced by aspergillus fungi are immunosuppressive agents, and their cytotoxicity may impair defense mechanisms in humans. the objective of the study was evaluation of the cytotoxicity of fungi isolated from an environment where inpatients with impaired immunity were present. the materials comprised 57 fungal strains: aspergillus fumigatus, aspergillus niger: aspergillus ochraceus, aspergillus flavus, aspergillus versicolor and aspergillus ustus isolated from hospital ... | 2011 | 21630575 |
| antifungal activity of redox-active benzaldehydes that target cellular antioxidation. | abstract: background: disruption of cellular antioxidation systems should be an effective method for control of fungal pathogens. such disruption can be achieved with redox-active compounds. natural phenolic compounds can serve as potent redox cyclers that inhibit microbial growth through destabilization of cellular redox homeostasis and/or antioxidation systems. the aim of this study was to identify benzaldehydes that disrupt the fungal antioxidation system. these compounds could then function ... | 2011 | 21627838 |
| chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man. | chronic granulomatous disease (cgd) is a rare congenital immunodeficiency that affects 1 : 250 000 of the population, which is characterized by recurrent bacterial and fungal infections and by granuloma formation. we investigated a 61-year-old man presented with a 20-year history of a relapsing skin rash appearing as mildly pruritic and erythematous plaques affecting various body regions. cutaneous biopsies were taken and sent for histology and tissue culture. leucocyte function was assessed by ... | 2011 | 21623884 |
| sidl is an a. fumigatus transacetylase involved in biosynthesis of the siderophores ferricrocin and hydroxyferricrocin. | the opportunistic fungal pathogen aspergillus fumigatus produces four types of siderophores, low molecular-mass iron chelators: it excretes fusarinine c (fsc) and triacetylfusarinine c (tafc) for iron uptake and accumulates ferricrocin (fc) for hyphal and hydroxyferricrocin (hfc) for conidial iron distribution and storage. siderophores biosynthesis has recently been shown to be crucial for fungal virulence. here, we identified a new component, afua_1g04450 termed sidl, of the fungal siderophore ... | 2011 | 21622789 |
| mycotic keratoconjunctivitis in 12-day-old red-legged partridges (alectoris rufa). | 2011 | 21622598 | |
| culture of a prosthetic valve excised for streptococcal endocarditis positive for aspergillus fumigatus 20 years after previous a fumigatus endocarditis. | culture of a mitral valve prosthesis excised for streptococcal endocarditis yielded aspergillus fumigatus. the patient had undergone valve replacement 20 years earlier for a fumigatus endocarditis. data suggest that quiescent a fumigatus may have survived in a biofilm on the surface of the prosthesis. an antifungal therapy was initiated for 6 months. | 2011 | 21619957 |
| bamboo processing can damage your health: a case of obstructing bronchial aspergillosis in a bamboo worker. | 2011 | 21615544 | |
| osteomyelitis due to aspergillus species in chronic granulomatous disease: an update of the literature. | chronic granulomatous disease (cgd) is a rare inherited disorder characterised by inability of phagocytes to kill catalase-positive organisms including certain fungi. aspergillus species are the most frequent fungal pathogens. this study is a systematic review of the reported cases of osteomyelitis due to aspergillus species in cgd patients. retrospective analysis of 46 osteomyelitis cases caused by aspergillus species in 43 cgd patients (three females) published in the english literature (pubme ... | 2011 | 21615532 |
| lecythomycin, a new macrolactone glycoside from the endophytic fungus lecythophora sp. | a new macrolactone glycoside, lecythomycin (1), 23-methyl-3-(1-o-mannosyl)-oxacyclotetracosan-1-one, was isolated from the endophytic fungus lecythophora sp. (code 30.1), an endopyte of the indonesian plant alyxia reinwardtii. the structure of 1 was elucidated on the basis of nmr spectroscopic and mass spectrometric data. the isolated compound displayed antifungal activity against strains of aspergillus fumigatus and candida kruzei at minimal inhibitory concentrations (mic) of 62.5-125 microg/ml ... | 2011 | 21615031 |
| identification of cryptic products of the gliotoxin gene cluster using nmr-based comparative metabolomics and a model for gliotoxin biosynthesis. | gliotoxin, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated with virulence of the opportunistic human pathogen aspergillus fumigatus. despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in part because few potential intermediates have been identified. in addition, previous studies suggest that knowledge of gli-dependent metabolites is incomplete. here we use differential analysis by 2d nmr spectros ... | 2011 | 21612254 |
| intravitreally implantable voriconazole delivery system for experimental fungal endophthalmitis. | purpose:: to investigate the therapeutic efficacy and optimal drug dose of an intravitreally implantable voriconazole (vcz) drug delivery system (dds) in experimental endophthalmitis of aspergillus fumigatus. methods:: vitrectomy was performed in albino rabbits with intravitreal inoculation of susceptible a. fumigatus. the animals were randomized into groups of control, polylactic-co-glycolic acid implantation, vcz injection, and intravitreal vcz dds containing 0.5, 0.9, and 1.2 mg of vcz, respe ... | 2011 | 21606889 |
| allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. | allergic bronchopulmonary aspergillosis (abpa) is a th2 hypersensitivity lung disease in response to aspergillus fumigatus that affects asthmatic and cystic fibrosis (cf) patients. sensitization to a. fumigatus is common in both atopic asthmatic and cf patients, yet only 1-2% of asthmatic and 7-9% of cf patients develop abpa. abpa is characterized by wheezing and pulmonary infiltrates which may lead to pulmonary fibrosis and/or bronchiectasis. the inflammatory response is characterized by th2 re ... | 2011 | 21603163 |
| phylogenetic and functional analysis of aspergillus fumigatus mgtc, a fungal protein homologous to a bacterial virulence factor. | mgtc is important for survival of several bacterial pathogens in the macrophages and for growth under magnesium limitation. among eukaryotes, a gene homologous to mgtc was only found in the pathogenic fungus aspergillus fumigatus. our data show that afumgtc protein does not share the same function as the bacterial mgtc proteins. | 2011 | 21602378 |
| studies on galactofuranose-containing glycostructures of the pathogenic mold aspergillus fumigatus. | galactofuranose is a hexose that is exclusively found in microbes and in particular in certain pathogenic species. in the mold aspergillus fumigatus, it is the characteristic constituent of the cell wall component galactomannan. detection of this carbohydrate is currently a widespread method used for diagnosis of systemic a. fumigatus infections. in this study, we raised and characterized 2 monoclonal antibodies that specifically react with galactofuranose-containing glycostructures. we investig ... | 2011 | 21601522 |
| microbiology specimens obtained at the time of surgical lung biopsy for interstitial lung disease: clinical yield and cost analysis. | objectives: in efforts to obtain complete results, current practice in surgical lung biopsy (lb) for interstitial lung disease (ild) recommends sending lung tissue samples for bacterial, mycobacterial, fungal, and viral cultures. this study assesses the value of this practice by evaluating the microbiology findings obtained from lb for ild and their associated costs. methods: a total of 296 consecutive patients (140 women, 156 men, median age=61 years) underwent lb for ild from 2002 to 2009. all ... | 2011 | 21601471 |
| [a clinical analysis of 9 cases of pulmonary alveolar proteinosis with secondary infection.] | objective: to describe the clinical characteristics of 9 cases of idiopathic pulmonary alveolar proteinosis (ipap) with secondary infections. method: the clinical and radiological data of 9 patients with ipap and secondary infections admitted into peking union medical college hospital from 1st january 1990 to 1st january 2010 were retrospectively analyzed. results: in that period, there were 97 patients of ipap were admitted in our hospital. there were 9 patients of ipap with secondary infection ... | 2011 | 21600085 |
| in vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. | abstract: background: suppression of immune system in treated cancer patients may lead to secondary infections that obviate the need of antibiotics. in the present study, an attempt was made to understand the occurrence of secondary infections in immuno-suppressed patients along with herbal control of these infections with the following objectives to: (a) isolate the microbial species from the treated oral cancer patients along with the estimation of absolute neutrophile counts of patients. (b) ... | 2011 | 21599889 |
| a rare, fatal case of invasive spinal aspergillosis in an antiretroviral-naive, hiv-infected man with pre-existing lung colonization. | infection of the central nervous system is a rare, but devastating complication of invasive aspergillosis. we report a case of invasive aspergillosis with spinal involvement in an hiv-infected patient without neutropenia. a 42-year-old antiretroviral-naive, hiv-infected man presented with progressive weakness in the lower limbs and urinary and fecal incontinence for two weeks. the patient had been prescribed broad-spectrum antibiotics and prednisone. he had upper motor neuron signs and a sensory ... | 2011 | 21596908 |
| [fungal infections in cystic fibrosis]. | fungal colonization in cystic fibrosis patient is frequent and dominated by aspergillus fumigatus (a. fumigatus). mycological analysis on specific media showed other filamentous species scedosporium, geosmithia argillacea. prospective studies are necessary to appreciate prevalence and pathogenicity in this pathology. a. fumigatus causes the most frequently allergic bronchopulmonary aspergillosis (abpa). invasive infection is exceptional in this context. an early diagnosis is important to avoid b ... | 2011 | 21596282 |
| antifungal properties of wheat histones (h1-h4) and purified wheat histone h1. | wheat ( triticum spp.) histones h1, h2, h3, and h4 were extracted, and h1 was further purified. the effect of these histones on specific fungi that may or may not be pathogenic to wheat was determined. these fungi included aspergillus flavus , aspergillus fumigatus , aspergillus niger , fusarium oxysporum , fusarium verticillioides , fusarium solani , fusarium graminearum , penicillium digitatum , penicillium italicum , and greeneria uvicola . non-germinated and germinating conidia of these fung ... | 2011 | 21595494 |
| triggering receptor expressed on myeloid cells-1 (trem-1) modulates immune responses to aspergillus fumigatus during fungal asthma in mice. | triggering receptor expressed on myeloid cells-1 (trem-1) expression is increased during pulmonary fungal infection suggesting that this receptor might be involved in anti-fungal immune responses. to address the role of trem-1 in a murine model of fungal allergic airway disease, a. fumigatus-sensitized cba/j mice received by intratracheal injection a mixture of live a. fumigatus conidia and one of a control adenovirus vector (ad70), an adenovirus containing a gene encoding for the extracellular ... | 2011 | 21592044 |
| unraveling terminal c-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. | the fungal peptidyl alkaloids of the tryptoquialanine and fumiquinazoline families are nonribosomally assembled by annulation of the indole side chain of fumiquinazoline f (fqf) with an alaninyl or aminoisobutyryl unit by monomodular nrps enzymes containing adenylation, thiolation, and condensation (a-t-c) domains. the af12060 and af12050 enzyme pair from aspergillus fumigatus thereby converts fqf to fqa, while the homologous tqah and tqab enzyme pair from penicillium aethiopicum makes the 2'-ep ... | 2011 | 21591693 |
| racemic resolution of some dl: -amino acids using aspergillus fumigatus l: -amino acid oxidase. | the ability of aspergillus fumigatus l: -amino acid oxidase (l: -aao) to cause the resolution of racemic mixtures of dl: -amino acids was investigated with dl: -alanine, dl: -phenylalanine, dl: -tyrosine, and dl: -aspartic acid. a chiral column, crownpak cr+ was used for the analysis of the amino acids. the enzyme was able to cause the resolution of the three dl: -amino acids resulting in the production of optically pure d: -alanine (100% resolution), d: -phenylalanine (80.2%), and d: -tyrosine ... | 2011 | 21590326 |
| a nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen aspergillus fumigatus. | while plasmacytoid dendritic cells (pdcs), a natural type i interferon (ifn)-producing cell type, are regarded as critical for innate immunity to viruses, their role in defense against fungal infections remains unknown. we examined the interactions of pdcs with hyphae of the invasive human fungal pathogen aspergillus fumigatus. human pdcs spread over hyphae and inhibited their growth. antifungal activity was retained in pdc lysates, did not require direct fungal contact, and was partially revers ... | 2011 | 21575912 |
| automated image analysis of the host-pathogen interaction between phagocytes and aspergillus fumigatus. | aspergillus fumigatus is a ubiquitous airborne fungus and opportunistic human pathogen. in immunocompromised hosts, the fungus can cause life-threatening diseases like invasive pulmonary aspergillosis. since the incidence of fungal systemic infections drastically increased over the last years, it is a major goal to investigate the pathobiology of a. fumigatus and in particular the interactions of a. fumigatus conidia with immune cells. many of these studies include the activity of immune effecto ... | 2011 | 21573171 |
| phagocyte responses towards aspergillus fumigatus. | the saprophytic fungus aspergillus fumigatus is a mold which is ubiquitously present in the environment. it produces large numbers of spores, called conidia that we constantly inhale with the breathing air. healthy individuals normally do not suffer from true fungal infections with this pathogen. a normally robust resistance against aspergillus is based on the presence of a very effective immunological defense system in the vertebrate body. inhaled conidia are first encountered by lung-resident ... | 2011 | 21571589 |
| identification of virulence determinants of the human pathogenic fungi aspergillus fumigatus and candida albicans by proteomics. | both fungi candida albicans and aspergillus fumigatus can cause a number of life-threatening systemic infections in humans. the commensal yeast c. albicans is one of the main causes of nosocomial fungal infectious diseases, whereas the filamentous fungus a. fumigatus has become one of the most prevalent airborne fungal pathogens. early diagnosis of these fungal infections is challenging, only a limited number of antifungals for treatment are available, and the molecular details of pathogenicity ... | 2011 | 21565549 |
| shaping the fungal adaptome - stress responses of aspergillus fumigatus. | aspergillus fumigatus as prime pathogen to cause aspergillosis has evolved as a saprophyte, but is also able to infect and colonise immunocompromised hosts. based on the 'dual use' hypothesis of fungal pathogenicity, general characteristics have to be considered as unspecific virulence determinants, among them stress adaptation capacities. the susceptible, warm-blooded mammalian host represents a specific ecological niche that poses several kinds of stress conditions to the fungus during the cou ... | 2011 | 21565548 |
| permanent genetic resources added to molecular ecology resources database 1 october 2009-30 november 2009. | this article documents the addition of 411 microsatellite marker loci and 15 pairs of single nucleotide polymorphism (snp) sequencing primers to the molecular ecology resources database. loci were developed for the following species: acanthopagrus schlegeli, anopheles lesteri, aspergillus clavatus, aspergillus flavus, aspergillus fumigatus, aspergillus oryzae, aspergillus terreus, branchiostoma japonicum, branchiostoma belcheri, colias behrii, coryphopterus personatus, cynogolssus semilaevis, cy ... | 2010 | 21565039 |
| paediatric flexible bronchoscopy and its indications. | paediatric flexible bronchoscopy (f.b.) with bronchoalveolar lavage (b.a.l.) is an increasingly important investigation. retrospective review of 180 fb performed over a 5 year period by a single operator was undertaken. common indications included recurrent lower respiratory tract infections (n = 92, 51%), persistent atelectasis (n = 43, 24%), persistent infiltrates (n = 18, 10%) and persistent consolidation (n = 17, 9%). normal airway anatomy was identified in the majority (n = 154, 85.5%). bro ... | 2010 | 21560502 |
| antioxidant, antihypertensive and antimicrobial properties of ovine milk caseinate hydrolyzed with a microbial protease. | background: bioactive peptides might be released from precursor proteins through enzymatic hydrolysis. these molecules could be potentially employed in health and food products. in this investigation, ovine milk caseinate hydrolysates obtained with a novel microbial protease derived from bacillus sp. p7 were evaluated for antioxidant, antimicrobial, and angiotensin i-converting enzyme (ace)-inhibitory activities. results: antioxidant activity measured by the 2,2'-azino-bis-(3-ethylbenzothiazolin ... | 2011 | 21560133 |
| on the way toward systems biology of aspergillus fumigatus infection. | pathogenicity of aspergillus fumigatus is multifactorial. thus, global studies are essential for the understanding of the infection process. therefore, a data warehouse was established where genome sequence, transcriptome and proteome data are stored. these data are analyzed for the elucidation of virulence determinants. the data analysis workflow starts with pre-processing including imputing of missing values and normalization. last step is the identification of differentially expressed genes/p ... | 2011 | 21555243 |
| phenotypic characteristics of isolates of aspergillus section fumigati from different geographic origins and their relationships with genotypic characteristics. | abstract: background: epidemiological studies worldwide have shown that a. fumigatus exhibits important phenotypic and genotypic diversity, and these findings have been of great importance in improving the diagnosis and treatment of diseases caused by this fungus. however, few studies have been carried out related to the epidemiology of this fungus in latin america. this study's aim is to report on the epidemiology of the fungus by analyzing the phenotypic variability of aspergillus section fumi ... | 2011 | 21554728 |
| protection of immunocompromised mice from fungal infection with a thymus growth-stimulatory component from selaginella involvens, a fern. | context: recent studies have shown that the water extract of selaginella involvens (sw.) spring, a wild fern, exhibits thymus growth-stimulatory activity in adult mice (reversal of involution of thymus) and remarkable anti-lipid peroxidation activity. follow-up studies were carried out in the present study. materials and methods: activity-guided isolation of the active component (ac) was carried out. the effect of ac on immune function was studied using fungal (aspergillus fumigatus) challenge i ... | 2011 | 21554105 |
| genetic susceptibility to aspergillus fumigatus infections. | invasive aspergillosis mostly caused by the opportunistic mould aspergillus fumigatus is characterized by high morbidity and mortality in risk group patients. several ethno-pathological factors promote the development and the course of this fungal infection like neutropenia, t-cell depletion, cd34-selected stem cell products, corticosteroid therapy, or cytomegalovirus infections. furthermore, a growing number of defined single nucleotide polymorphisms affiliated to genes affecting the innate imm ... | 2011 | 21550849 |
| nutrient acquisition by pathogenic fungi: nutrient availability, pathway regulation, and differences in substrate utilization. | all pathogenic microorganisms have in common that they need to feed on nutrients available from their host. therefore, the specific interruption of metabolic pathways is a promising approach which could lead to the discovery of new antimicrobial drugs. however, nutrient availability strongly varies in respect to the infected host niche and pathogens may possess different strategies to acquire nutrients. this review focuses on the differences in regulation and use of key metabolic pathways during ... | 2011 | 21550848 |
| actin depolymerizing effect of trisoxazole-containing macrolides. | oxazole-containing macrolides (1-5) isolated from the marine sponge chondrosia corticata were evaluated for their actin depolymerizing activities by monitoring fluorescent intensity of pyrene f-actin. these studies led to the identification of (19z)-halichondramide (5) as a new actin depolymerizing agent. the actin depolymerizing activity by (19z)-halichondramide (5) was four times more potent than that of halichondramide (1). compounds 1 and 5 also have potent antifungal activity. the prelimina ... | 2011 | 21550239 |
| identification of lethal aspergillus at early growth stages based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | delayed and incorrect diagnoses are potential risk factors leading to high mortality of invasive aspergillosis (ia). matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to acquire a wide mass spectral range and characterize the early process of asexual sporulation of lethal ia pathogens recovered on agar plates. proteins were extracted using trifluoroacetic acid and soft ionized using an ultraviolet laser with the assistance of ferulic acid. at the second stage ... | 2011 | 21546196 |
| quality control guidelines for amphotericin b, itraconazole, posaconazole and voriconazole disk diffusion susceptibility tests on non-supplemented mueller-hinton agar (clsi m51-a document) of nondermatophyte filamentous fungi. | although clsi disk diffusion assay standard conditions are available for susceptibility testing of filamentous fungi (moulds) to antifungal agents, quality control (qc) disk diffusion zone diameter ranges have not been established. this multicenter study documented the reproducibility of tests for one isolate each of five moulds (paecilomyces variotii atcc mya-3630, aspergillus fumigatus atcc mya-3626, a. flavus atcc mya-3631, a. terreus atcc mya-3633, and fusarium verticillioides [moniliforme] ... | 2011 | 21543581 |
| high-yields heterologous production of the novel aspergillus fumigatus elastase inhibitor afuei in aspergillus oryzae. | afuei, an elastase inhibitor produced by aspergillus fumigatus strongly inhibits the elastolytic activity of a. fumigatus etc. to purify afuei, we constructed a strain that overproduces afuei by introducing the gene encoding afuei (genbank accession no. ab546725) under control of the amyb promoter into the heterologous host aspergillus oryzae. a. oryzae tf-4 displayed strong elastase inhibitory activity and produced considerably more afuei than that of a. fumigatus. furthermore, afuei could be p ... | 2011 | 21543256 |
| [salvage treatment with infliximab of steroid-resistant graft-versus-host disease in allogeneic transplanted patients.] | background and objective: severe acute graft versus host disease (gvhd) and extensive chronic gvhd not responding to steroids have poor prognosis. infliximab has reported to be effective in some of these patients. the efficacy of infliximab for the treatment of patients with steroid-resistant gvhd was evaluated. patients and methods: retrospective analysis to evaluate the activity and toxicity of infliximab in 9 patients with acute or chronic steroid resistant gvhd. results: six patients had acu ... | 2011 | 21543091 |
| spontaneous empyema necessitatis caused by aspergillus fumigatus in an immunocompetent patient. | 2011 | 21541073 | |
| therapeutic and toxicologic studies in a murine model of invasive pulmonary aspergillosis. | invasive pulmonary aspergillosis remains problematic in immunocompromised patient populations. we studied potential therapeutic options in a murine model of pulmonary aspergillosis in triamcinolone-suppressed dba/2 mice infected intranasally with conidia from aspergillus fumigatus. mice were treated with liposomal-amphotericin b (ambi; ambisome), lipid-complexed amphotericin b (ablc; abelcet), voriconazole (vcz), micafungin (mica), caspofungin (cas) or deoxycholate amphotericin b (ambd) given al ... | 2011 | 21539507 |
| distribution of micafungin in the tissue fluids of patients with invasive fungal infections. | the distribution of micafungin (mcfg) in tissue fluids, such as cerebrospinal fluid (csf), pleural effusions, ascites, and wound tissue fluids, was examined in seven patients with invasive fungal infections. mcfg (100-300 mg) was administered once daily over a 1-h intravenous infusion. blood and tissue fluid samples were collected from 1 to 24 h after infusion. although two patients had similar mcfg concentrations in their plasma, the concentrations in the csf differed between these two patients ... | 2011 | 21537970 |
| identification of virulence factors and diagnostic markers using immunosecretome of aspergillus fumigatus. | aspergillus fumigatus is a prime causative agent for various allergic and invasive aspergillosis. there has been a dramatic increase of such cases in last three decades yet the early diagnosis and virulence factor identification remains the challenge. in the present study secretome analysis of proteins isolated from the culture filtrate was done by 2d gel electrophoresis coupled with ms/ms and the immunosecretome analysis was carried out using immunoblotting of 2d transfer blots and probed with ... | 2011 | 21536156 |
| role of germination in murine airway cd8 t-cell responses to aspergillus conidia. | pulmonary exposure to aspergillus fumigatus has been associated with morbidity and mortality, particularly in immunocompromised individuals. a. fumigatus conidia produce β-glucan, proteases, and other immunostimulatory factors upon germination. murine models have shown that the ability of a. fumigatus to germinate at physiological temperature may be an important factor that facilitates invasive disease. we observed a significant increase in ifn-γ-producing cd8(+) t cells in bronchoalveolar lavag ... | 2011 | 21533200 |
| abpa or afaa: that is the question. | 2011 | 21531957 | |
| calcineurin controls drug tolerance, hyphal growth, and virulence in candida dubliniensis. | candida dubliniensis is an emerging pathogenic yeast species closely related to candida albicans and frequently found colonizing or infecting the oral cavities of hiv/aids patients. drug resistance during c. dubliniensis infection is common and constitutes a significant therapeutic challenge. the calcineurin inhibitor fk506 exhibits synergistic fungicidal activity with azoles or echinocandins in the fungal pathogens c. albicans, cryptococcus neoformans, and aspergillus fumigatus. in this study, ... | 2011 | 21531874 |
| associations between fungal species and water damaged building materials. | fungal growth in damp or water damaged buildings worldwide is an increasing problem, which has adverse effects on both the occupants and the buildings. air sampling alone in moldy buildings does not reveal the full diversity of fungal species growing on building materials. one aim of this study was to estimate the qualitative and quantitative diversity of fungi growing on damp or water damaged building materials. another was to determine if associations exist between the most commonly found fung ... | 2011 | 21531835 |
| widespread nodules in an immunosuppressed adult. | 2011 | 21530930 | |
| antitumor and antimicrobial activities of endophytic fungi from medicinal parts of aquilaria sinensis. | the purpose of this study was to isolate and characterize endophytic fungi from the stem tissue which can produce fragrant ingredients in aquilaria sinensis (also called agarwood) to determine their antitumor and antimicrobial activities. twenty-eight fungal endophytes were isolated from agarwood by strict sterile sample preparation and were classified into 14 genera and 4 taxonomic classes (sordariomycetes, dothideomycetes, saccharomycetes, and zygomycetes) based on molecular identification. of ... | 2011 | 21528493 |
| repression of n-glycosylation triggers the unfolded protein response (upr) and over-expression of cell wall protein and chitin in aspergillus fumigatus. | aspergillus fumigatus is the most common airborne fungal pathogen, causing fatal invasive aspergillosis in immunocompromised patients. the crude mortality is 60-90% and remains around 29-42% even treated. the main reason for patient death is the low efficiency of the drug therapies. as protein n-glycosylation is involved in cell wall biogenesis in a. fumigatus, a deep understanding of its role in cell wall biogenesis will help to develop new drug targets. the afstt3 gene encodes the essential ca ... | 2011 | 21527474 |
| current perspectives on echinocandin class drugs. | it has been nearly a decade since caspofungin was approved for clinical use as the first echinocandin class antifungal agent, followed by micafungin and anidulafungin. the echinocandin drugs target the fungal cell wall by inhibiting the synthesis of β-1,3-d-glucan, a critical cell wall component of many pathogenic fungi. they are fungicidal for candida spp. and fungistatic for moulds, such as aspergillus fumigatus, where they induce abnormal morphology and growth properties. the echinocandins ha ... | 2011 | 21526945 |
| aspergillus fumigatus infection as a delayed manifestation of prosthetic knee arthroplasty and a review of the literature. | abstract fungal infection after total joint arthroplasty is a very rare but serious complication and a challenge to the treating and consulting physicians. the literature includes little information about the treatment protocol for aspergillus infection after total knee arthroplasty, since only 3 cases have been reported. we describe the case of a non-immunocompromised patient who lacked predisposing risk factors and presented with pain and swelling. an aspiration under sterile conditions reveal ... | 2011 | 21526903 |
| the role of glutathione s-transferase glig in gliotoxin biosynthesis in aspergillus fumigatus. | gliotoxin, a redox-active metabolite, is produced by the opportunistic fungal pathogen aspergillus fumigatus, and its biosynthesis is directed by the gli gene cluster. knowledge of the biosynthetic pathway to gliotoxin, which contains a disulfide bridge of unknown origin, is limited, although l-phe and l-ser are known biosynthetic precursors. deletion of glig from the gli cluster, herein functionally confirmed as a glutathione s-transferase, results in abrogation of gliotoxin biosynthesis and ac ... | 2011 | 21513890 |
| rapid identification of aspergillus fumigatus within the section fumigati. | abstract: | 2011 | 21510879 |
| aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on aspergillus fumigatus azole resistance. | respiratory tract colonization by molds in patients with cystic fibrosis (cf) were analyzed, with particular focus on the frequency, genotype, and underlying mechanism of azole resistance among aspergillus fumigatus isolates. clinical and demographic data were also analyzed. a total of 3,336 respiratory samples from 287 cf patients were collected during two 6-month periods in 2007 and 2009. azole resistance was detected using an itraconazole screening agar (4 mg/liter) and the eucast method. cyp ... | 2011 | 21508152 |
| comparison of an aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalvelolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients. | early diagnosis and treatment of invasive pulmonary aspergillosis (ipa) improves outcome. | 2011 | 21507918 |
| failure of posaconazole therapy in a renal transplant patient with invasive aspergillosis due to aspergillus fumigatus with attenuated susceptibility to posaconazole. | we report the case of a kidney transplant recipient with invasive aspergillosis due to aspergillus fumigatus resistant to voriconazole and intermediately susceptible to posaconazole who failed to posaconazole therapy. plasma posaconazole concentrations indicated an unfavorable area under the concentration-time curve over mic ratio. posaconazole should be used with caution in invasive aspergillosis caused by strains with attenuated posaconazole susceptibility, as drug exposure may be inadequate r ... | 2011 | 21502625 |
| phagocytosis of melanized aspergillus conidia by macrophages exerts cytoprotective effects by sustained pi3k/akt signalling. | host cell death is a critical component of innate immunity and often determines the progression and outcome of infections. the opportunistic human pathogen aspergillus fumigatus can manipulate the immune system either by inducing or by inhibiting host cell apoptosis dependent on its distinct morphological form. here, we show that conidia of aspergillus ssp. inhibit apoptosis of macrophages induced via the intrinsic (staurosporine) and extrinsic (fas ligand) pathway. hence, mitochondrial cytochro ... | 2011 | 21501368 |
| fungalrv: adhesin prediction and immunoinformatics portal for human fungal pathogens. | abstract: | 2011 | 21496229 |
| new insights into ergot alkaloid biosynthesis in claviceps purpurea: an agroclavine synthase easg catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-i aldehyde to agroclavine. | ergot alkaloids are indole derivatives with diverse structures and biological activities. they are produced by a wide range of fungi with claviceps purpurea as the most important producer for medical use. chanoclavine-i aldehyde is proposed as a branch point via festuclavine or pyroclavine to clavine-type alkaloids in trichocomaceae and via agroclavine to ergoamides and ergopeptines in clavicipitaceae. here we report the conversion of chanoclavine-i aldehyde to agroclavine by easg from claviceps ... | 2011 | 21494745 |
| prevalence of dermatophytosis among primary school children in oke-oyi community of kwara state. | background: dermatophytic infections have been known to impact negatively on health and well-being of children. this study was undertaken to determine the prevalence, clinical types as well as the etiologic organisms of dermatophyte infection among primary school children aged 5-16 years in oke-oyi community in kwara state. materials and methods: a 4-months descriptive cross-sectional survey was carried out among 602 children aged 5-16 years in oke-oyi community, in kwara state. results: the pre ... | 2011 | 21493987 |
| collaborative cross mice and their power to map host susceptibility to aspergillus fumigatus infection. | the collaborative cross (cc) is a genetic reference panel of recombinant inbred lines of mice, designed for the dissection of complex traits and gene networks. each line is independently descended from eight genetically diverse founder strains such that the genomes of the cc lines, once fully inbred, are fine-grained homozygous mosaics of the founder haplotypes. we present an analysis of 120 cc lines, from a cohort of the cc bred at tel aviv university in collaboration with the university of oxf ... | 2011 | 21493779 |
| a novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen aspergillus fumigatus. | during a search for genes controlling conidial dormancy in aspergillus fumigatus, two dehydrin-like genes, dpra and dprb, were identified. the deduced proteins had repeated stretches of 23 amino acids that contained a conserved dehydrin-like protein (dpr) motif. disrupted dpraδ mutants were hypersensitive to oxidative stress and to phagocytic killing, whereas dprbδ mutants were impaired in osmotic and ph stress responses. however, no effect was observed on their pathogenicity in our experimental ... | 2011 | 21490150 |
| synthesis and antifungal activity of functionalized 2,3-spirostane isomers. | invasive fungal infections are a major complication for individuals with compromised immune systems. one of the most significant challenges in the treatment of invasive fungal infections is the increased resistance of many organisms to widely used antifungals, making the development of novel antifungal agents essential. many naturally occurring products have been found to be effective antimicrobial agents. in particular, saponins with spirostane glycosidic moieties-isolated from plant or marine ... | 2011 | 21489791 |
| a role for macrophage migration inhibitory factor in protective immunity against aspergillus fumigatus. | inflammation plays an important role in protective immunity against fungi, including the opportunistic pathogen, aspergillus fumigatus. the balance between pro-inflammatory and anti-inflammatory cytokines is a key determinant of infection outcome. since macrophage migration inhibitory factor (mif) is an upstream regulator of many cytokines, we analyzed herein the role of endogenous mif in the host control of hematogenously disseminated aspergillosis using mif(-/-) mice. as revealed by their mort ... | 2011 | 21489649 |
| banana peel: a potential substrate for laccase production by aspergillus fumigatus vkj2.4.5 in solid-state fermentation. | in solid-state fermentation, among various solid supports evaluated, banana peel was found to be an ideal support and resulted into higher levels of laccase (6281.4 ± 63.60 u l(-1)) along with notable levels of manganese peroxidase production (1339.0 ± 131.23 u l(-1)) by aspergillus fumigatus vkj2.4.5. maximum levels of laccase was achieved under derived conditions consisting of 80% of moisture level, 6 days of incubation period, 6% inoculum level, and an aeration level of 2.5 l min(-1). a colum ... | 2011 | 21487735 |
| comparative in vivo dose-dependent activity of caspofungin and anidulafungin against echinocandin-susceptible and -resistant aspergillus fumigatus. | background echinocandin resistance in aspergillus species is rare. we examined if mutations in fks1 would result in a complete loss of echinocandin activity in vivo in an experimental model of aspergillosis. methods neutropenic mice were infected with either an echinocandin-susceptible aspergillus fumigatus (af 293) or an echinocandin-resistant a. fumigatus laboratory strain harbouring 'hot-spot' substitution in fks1p (af ser678pro). mice then received daily treatment with either anidulafungin o ... | 2011 | 21486855 |
| epidemiology and antifungal resistance in invasive aspergillosis according to primary disease: review of the literature. | aspergilli, less susceptible to antifungals emerge and resistance to azoles have been found mainly in aspergillus fumigatus; this has launched a new phase in handling aspergillosis. resistant strains have currently been reported from belgium, canada, china, denmark, france, norway, spain, sweden, the netherlands, uk and the usa. centres in the uk (manchester) and the netherlands (nijmegen) have described particularly high frequencies (15 and 10% respectively), and a significant increase in azole ... | 2011 | 21486729 |
| novel aspergillus hemicellulases enhance performance of commercial cellulases in lignocellulose hydrolysis. | a novel hemicellulase-producing fungal strain was isolated from a local soil sample. the organism is identified as aspergillus fumigatus based on ribosomal rna analyses. the aspergillus strain, designated as 2nb, produces both enzymes acting on xylan backbone (xylanase and β-xylosidase), and those acting on side chains (or accessory enzymes) notably α-arabinofuranosidase and acetyl-xylan esterase. the asperigillus hemicellulases are characterized as having relatively low xylanase and β-xylosidas ... | 2011 | 21485035 |
| [epidemiological, clinical, therapeutic and evolutionary aspects of pulmonary aspergilloma in dakar]. | the presentation of pulmonary aspergilloma is dominated by haemoptysis, the results of medical treatment are disappointing and there is significant morbidity and mortality following surgery; the only really curative treatment. these facts emphasise the gravity of this condition. we undertook a study to estimate the current profile of the disease and its management in senegal. | 2011 | 21482335 |
| the role of reactive oxygen intermediates in experimental coccidioidomycois in mice. | abstract: | 2011 | 21481258 |