Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| longitudinal evaluation of herpes simplex virus dna load during episodes of herpes labialis. | few studies have performed sequential evaluation of the herpes simplex virus (hsv) load using quantitative pcr during episodes of herpes labialis. | 2006 | 17046320 |
| design, synthesis, and biological evaluation of novel iso-d-2',3'-dideoxy-3'-fluorothianucleoside derivatives. | novel iso-d-2',3'-dideoxythianucleoside derivatives 1-4 were designed and asymmetrically synthesized as a bioisostere of lamivudine to search for new anti-hiv agents. the information about using sulfur participation occurred on dast fluorination and mitsunobu reaction will be of great help in synthesizing sulfur-containing compounds. final compounds 1-4 were evaluated against hiv-1 and 2, hsv-1 and 2, emcv, cox. b3, vsv, flua (taiwan), flua (johan.), fcv, and fip. only cytosine analogue 3 showed ... | 2007 | 17046264 |
| hiv among pregnant women in moshi tanzania: the role of sexual behavior, male partner characteristics and sexually transmitted infections. | women continue to be disproportionately affected by hiv in tanzania, and factors contributing to this situation need to be identified. the objective of this study was to determine social, behavioral and biological risk factors of hiv infection among pregnant women in moshi urban, tanzania. in 2002-2004, consenting women (n = 2654), attending primary health clinics for routine antenatal care were interviewed, examined and biological samples collected for diagnosis of hiv and other sexually transm ... | 2006 | 17044932 |
| herpes simplex and epstein-barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine. | multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (cll). we describe a patient with a cll who developed an herpes virus lymphadenitis. inmunohistochemical study was positive for hsv-1, hsv-2, and epstein-barr virus (ebv). the coinfection of ebv with a profile of expresion of viral latent genes type iii, is usually seen in inmunodepressed patients. to the best of our knowledge, this is the first reported case of a multiple human herpes vi ... | 2006 | 17044837 |
| effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a us-based randomized, double-blind, placebo-controlled clinical trial. | to determine the efficacy of daily suppressive therapy with a 1-g dose of valacyclovir in reducing total (clinical and subclinical) herpes simplex virus 2 (hsv-2) shedding compared with placebo in immunocompetent patients diagnosed as having recurrent hsv-2 genital herpes. | 2006 | 17036557 |
| interactions between human papillomavirus and other sexually transmitted agents in the etiology of cervical cancer. | the interplay between human papillomavirus, notably type 16, and hiv in cervical carcinogenesis leads to persistent infection and cervical neoplasia by destruction of the afferent arm (langerhans cells) of the host immune system. the joint effect takes place at the early stages of squamous intraepithelial lesions and has severe consequences if left untreated. the recent increase of cervical cancer mortality in young women in developed countries may well be a result of the hiv epidemic. infection ... | 1999 | 17035763 |
| characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients. | although cytomegalovirus (cmv) disease is a severe complication among immunocompromised patients, its cutaneous features have not been frequently reported. as herpes simple virus (hsv) infection commonly develops in cmv skin lesions, a study is needed on the pathogenetic role of cmv in cutaneous lesion formation. | 2006 | 17034528 |
| recurrent benign lymphocytic meningitis. | recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. this syndrome is associated with transient neurological symptoms in one-half of afflicted patients. the causative agent is usually herpes simplex virus type 2, which can be confirmed by detection of viral dna in the cerebrospinal fluid using polymerase chain reaction. clinical disease resolves spontaneously; however, acyclovir, valacyclovir, and famciclovir have been administered to s ... | 2006 | 17029141 |
| the growth compromised hsv-2 mutant deltarr prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. | we have previously shown that the hsv-2 anti-apoptotic protein icp10pk is delivered by the replication incompetent virus mutant deltarr and prevents kainic acid (ka)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. the present studies used deltarr and the icp10pk deleted virus mutant deltapk to examine the mechanism of neuroprotection. deltarr-infected neuronal cells expressed a chimeric protein in which icp10pk is fused in frame to lacz ... | 2006 | 17020750 |
| antiviral sulfated polysaccharide from navicula directa, a diatom collected from deep-sea water in toyama bay. | a sulfated polysaccharide named naviculan was isolated from a diatom, navicula directa (w. smith) ralfs, collected in deep sea water from toyama bay. the polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. it showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza a virus with selectivity indices (cc50/ic50) of 270, 510 and 32, respectively. naviculan also showed an inhibitory effect on c ... | 2006 | 17015966 |
| chlamydia trachomatis and herpes simplex virus 2 infection in vulvar intraepithelial neoplasia associated with human papillomavirus. | the role of viral and bacterial co-infection is stressed in vin. a view that vin is a sexually transmitted disease made the area of research larger and stimulated scientists to seek other sexually transmitted factors, among which chlamydia trachomatis and herpes simplex are frequently examined. | 2006 | 17009637 |
| multiphasic encephalomyelitis in a patient with recurrent herpes simplex type 2 meningitis. | we here describe a patient with a history of recurrent hsv-2 meningitis who had been free from symptoms for almost 20 y when he developed an acute encephalomyelitis. the clinical course laboratory and radiological findings support an acute multiphasic disseminated encephalomyelitis induced by a recurrent hsv-2 infection. | 2006 | 17008246 |
| prevalence of herpes simplex virus types 1 and 2 among children and adolescents attending a sexual abuse clinic. | children and adolescents with a history of sexual abuse are at risk for acquiring herpes simplex virus (hsv) type 2. we evaluated the prevalence of hsv-1 and hsv-2 and the usefulness for this population of 2 commercially available tests. | 2006 | 17006285 |
| quantification of poly(i:c)-mediated protection against genital herpes simplex virus type 2 infection. | alternative strategies for controlling the growing herpes simplex virus type 2 (hsv-2) epidemic are needed. a novel class of immunomodulatory microbicides has shown promise as antiherpetics, including intravaginally applied cpg-containing oligodeoxynucleotides that stimulate toll-like receptor 9 (tlr9). in the current study, we quantified protection against experimental genital hsv-2 infection provided by an alternative nucleic acid-based tlr agonist, polyinosine-poly(c) (pic) (tlr3 agonist). us ... | 2006 | 17005677 |
| induction of innate immunity against herpes simplex virus type 2 infection via local delivery of toll-like receptor ligands correlates with beta interferon production. | toll-like receptors (tlrs) constitute a family of innate receptors that recognize and respond to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa. previous studies have demonstrated that ligands for tlr3 and tlr9 induce potent innate antiviral responses against herpes simplex virus type 2 (hsv-2). however, the factor(s) involved in this innate protection is not well-defined. here we report that production of beta interferon (ifn-beta) but not production of ifn- ... | 2006 | 17005672 |
| 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. synthesis and antiviral activity of all stereoisomers1. | all stereoisomers of adenine and guanine methylene-3-fluoromethylenecyclopropane analogues of nucleosides 9a, 9b, 10a, 10b, 11a, 11b, 12a, and 12b were synthesized and their antiviral activities were evaluated. a highly convergent approach permitted the synthesis of all these analogues using a single intermediate 15. reaction of aldehyde 13 with fluorotrichloromethane and tri-n-butylphosphine gave fluoroalkenes 14a+14b (83:17). addition of carbene derived from ethyl diazoacetate gave cyclopropan ... | 2006 | 17004726 |
| primary treatment of acute retinal necrosis with oral antiviral therapy. | to explore the possibility of oral antiviral therapy in lieu of intravenous acyclovir for treating acute retinal necrosis (arn), a necrotizing retinopathy caused by herpes simplex virus type 1 or 2 or by varicella zoster virus. | 2006 | 16996614 |
| high incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from hiv-1-seropositive patients with recurrent genital herpes. | we developed a polymerase chain reaction (pcr) method, based on strain-to-strain variation of dna repeats in the herpes simplex virus type 2 (hsv-2) genes us1 and us12, to genotype hsv-2 strains and determine the incidence and risk factors associated with hsv-2 superinfection in patients with recurrent genital herpes (rgh). forty-seven (92%) of 51 unrelated hsv-2 isolates could be distinguished. genotyping of sequential hsv-2 isolates showed a different genotype in all of the 11 human immunodefi ... | 2006 | 16991086 |
| the microenvironment of vulvar skin in women with symptomatic and asymptomatic herpes simplex virus type 2 (hsv-2) infection. | it is not known why some individuals infected with herpes simplex virus type 2 (hsv-2), experience frequent recurrences, while most of those infected have a completely silent infection. | 2006 | 16987263 |
| [perianal herpetic ulcers in a patient with previously undiagnosed human immunodeficiency virus]. | 2006 | 16978553 | |
| possible reasons for an increase in the proportion of genital ulcers due to herpes simplex virus from a cohort of female bar workers in tanzania. | to determine trends in the prevalence and aetiological distribution of genital ulcer syndrome (gus) in a cohort of female bar workers and to assess factors associated with these trends. | 2007 | 16971402 |
| development of an internally controlled, homogeneous polymerase chain reaction assay for the simultaneous detection and discrimination of herpes simplex virus types 1 and 2 and varicella-zoster virus. | homogeneous polymerase chain reaction (pcr) technology is being used increasingly in the diagnosis of infectious disease. the sensitivity and specificity of pcr is being coupled to the ease-of-use and multiplexing capacity of homogeneous methodologies to provide rapid and accurate differential diagnoses. this technology is applicable to the diagnosis of infections with the human herpes viruses, herpes simplex virus 1 (hsv 1), hsv 2 and varicella-zoster virus (vzv). our aim was to develop and eva ... | 2007 | 16963223 |
| universal prenatal herpes screening is a bad idea in pregnancy. | 2006 | 16962863 | |
| invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2. | we report here on the development and validation of a prototype invader plus method for the qualitative detection of herpes simplex virus types 1 and 2 in cerebrospinal fluid (csf). the method combines pcr and invader techniques in a single, closed-tube, continuous-reaction format that gives an analytical sensitivity of approximately 10 copies per reaction. the clinical sensitivity and specificity were 100.0% and 98.6%, respectively, when the results of the method were validated against the resu ... | 2006 | 16954297 |
| role of bcl-2 expression for productive herpes simplex virus 2 replication. | herpes simplex viruses infect a variety of cells in vitro. however, not all infected cells sustain a fully productive replication of these viruses. we have shown that, in u937 monocytoid cells, herpes simplex virus 2 (hsv-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. this effect was associated with a down-regulation of the bcl-2 protein. we therefore asked whether destabilization of bcl-2 expression could act as a limiting fact ... | 2006 | 16950491 |
| chapter 1: hpv in the etiology of human cancer. | the causal role of human papillomavirus (hpv) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. most cancers of the vagina and anus are likewise caused by hpv, as are a fraction of cancers of the vulva, penis, and oropharynx. hpv-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus and for about 30-40% of cancers of the vulva, penis, and oropharynx. other cancers causally linked to hpv are non-melanoma skin cancer and canc ... | 2006 | 16949995 |
| acidform inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. | the acidic vaginal milieu is presumed to inactivate pathogens but is neutralized by semen. this notion fostered the development of acid-buffering products, such as acidform (developed by program for topical prevention of conception and disease, rush university, and licensed by instead), as microbicides. however, the extent and mechanism of protective activity provided by buffering gels is not known. exposure of herpes simplex virus (hsv) to ph 4.5 or lower irreversibly inactivated hsv and reduce ... | 2006 | 16941346 |
| herpes simplex virus type 2 (hsv-2) infection in women attending an antenatal clinic in the south pacific island nation of vanuatu. | the objective of this study was to estimate the prevalence and correlates of herpes simplex virus type 2 infection in women in an antenatal clinic in the south pacific island nation of vanuatu. | 2007 | 16940899 |
| microarray assay for detection and discrimination of orthopoxvirus species. | a microarray method was developed for simultaneous detection and identification of six species of orthopoxvirus (opv) including variola, monkeypox, cowpox, camelpox, vaccinia, and ectromelia viruses. the method allowed us to discriminate opv species from varicella-zoster virus (vzv), herpes simplex 1 virus (hsv-1), and herpes simplex 2 virus (hsv-2) that cause infections with clinical manifestations similar to opv infections. the nucleotide sequences of the c23l/b29r and the b19r genes identifie ... | 2006 | 16927285 |
| intercellular trafficking and cytotoxicity of recombinant hsv-1 thymidine kinase fused with hsv-2 us11 rxp repeat peptide. | to improve the therapeutic efficacy of herpes simplex virus type 1 (hsv-1) thymidine kinase (tk)/ganciclovir (gcv) therapy, we have made recombinant tk chimeras fused with the arginine-rich (rxp) repeat of herpes simplex virus type 2 (hsv-2) us11 and examined their activity of intercellular trafficking and cytotoxicity. when examined the immunofluorescence staining patterns of rxp/tk fusion proteins in transfected cos7 cells, the rxp chimeras revealed a conservation of the trafficking activity o ... | 2007 | 16927131 |
| trends in herpes simplex virus type 1 and type 2 seroprevalence in the united states. | herpes simplex virus type 1 (hsv-1) and type 2 are common infections worldwide. herpes simplex virus type 2 (hsv-2) is the cause of most genital herpes and is almost always sexually transmitted. in contrast, hsv-1 is usually transmitted during childhood via nonsexual contacts. preexisting hsv-1 antibodies can alleviate clinical manifestations of subsequently acquired hsv-2. furthermore, hsv-1 has become an important cause of genital herpes in some developed countries. | 2006 | 16926356 |
| influence of storage temperature on the stability of hiv-1 rna and hsv-2 dna in cervicovaginal secretions collected by vaginal washing. | variability in the handling of samples of genital secretions prior to quantitation of hiv-1 rna and hsv dna may profoundly affect both the detection and quantitation of these nucleic acids. over 144 h, we evaluated, the influence of storage temperature (4 degrees c, 20 degrees c, 30 degrees c) on the quantity of hiv-1 rna and hsv-2 dna in hiv and hsv negative cervicovaginal lavage pools spiked with known amounts of hiv-1 and hsv-2 and in hiv-1 and hsv-2 co-infected cervicovaginal lavage pools. t ... | 2006 | 16919788 |
| herpes simplex virus in the saliva of peripheral bell's palsy patients. | the first herpes virus to be described was types 1 and 2, whose denomination is herpes simplex 1 and 2 or hsv-1 and hsv-2. these viruses have specific biological characteristics, such as the ability to cause different kinds of diseases, as well as to establish hosts latent or persistent lifetime infections and also of being reactivated, causing lesions that can be located at the same site of the initial primary infection or close to it. it is suggested that this virus reactivation in the genicul ... | 2006 | 16917546 |
| risk of herpes simplex virus type 2 acquisition increases over early adulthood: evidence from a cohort study. | design/ setting: a cohort study of 1037 people born in dunedin, new zealand, in 1972 or 1973. | 2007 | 16916882 |
| hsv-2 suppression reduces hiv and hsv shedding. | 2005 | 16909510 | |
| subtly impaired humoral immunity predisposes to frequently recurring genital herpes simplex virus type 2 infection and herpetic neuralgia. | immunogenetic factors predisposing to recurrent genital herpes remain poorly characterized. | 2006 | 16897653 |
| transmission of herpes simplex virus types 1 and 2 in a prospective cohort of hiv-negative gay men: the health in men study. | despite increasing reports of herpes simplex virus (hsv) type 1 (hsv-1)-associated anogenital herpes, there are very limited data comparing the seroepidemiological profile of and risk factors for hsv-1 and hsv type 2 (hsv-2) infection. | 2006 | 16897652 |
| high risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the explore study. | the relation between herpes simplex virus type 2 (hsv-2) and human immunodeficiency virus (hiv) acquisition was evaluated among 4,295 high-risk, hiv-negative men who have sex with men in an intensive behavioral intervention (colloquially referred to as "explore") study in the united states from 1999 to 2003. sexual behavior data were obtained by computer-assisted self-interview, and sera were collected semiannually for hiv and hsv-2 serology. hsv-2 infection was classified as "recent incident" ( ... | 2006 | 16896053 |
| toll-like receptors, innate immunity and hsv pathogenesis. | in the last decade, substantial progress has been made in understanding the molecular mechanisms involved in initial host responses to viral infections, and how viral recognition leads to the innate responses that ultimately shape the adaptive immune response. viruses, including herpes simplex virus (hsv) types 1 and 2, trigger toll-like receptors (tlrs) that elicit cytokine and chemokine production. in turn, this can create local resistance and modulate t- and b-cell-mediated immunity. tlr acti ... | 2006 | 16895653 |
| the lack of rna-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. | mice deficient in rna-dependent protein kinase (pkr-/-) or deficient in pkr and a functional 2',5'-oligoadenylate synthetase (oas) pathway (pkr/rl-/-) are more susceptible to genital herpes simplex virus type 2 (hsv-2) infection than wild-type mice or mice that are deficient only in a functional oas pathway (rl-/-) as measured by survival over 30 days. the increase in susceptibility correlated with an increase in virus titre recovered from vaginal tissue or brainstem of infected mice during acut ... | 2006 | 16895559 |
| [expression of multi-copy and immuno-reactivity of recombinant type-specific epitope of herpes simplex virus type 1]. | to express a multi-copy specific epitope recombinant protein of herpes simplex virus type 1 (hsv-1) with immuno-reactivity. | 2006 | 16894929 |
| prevalence of antibodies against herpes simplex virus types 1 and 2 in children and young people in an urban region in tanzania. | herpes simplex virus type 1 (hsv-1) is transmitted by close contact, both sexual and nonsexual, and infections are acquired during childhood and adolescence. herpes simplex virus type 2 (hsv-2), however, is thought to be transmitted mainly by sexual contact. most hsv-2 infections are consequently expected to occur after the onset of sexual activity. recent reports indicate an increasing prevalence of hsv-2 on the african continent, but most studies have been performed on adult cohorts. in the pr ... | 2006 | 16891495 |
| body mass index, sexual behaviour, and sexually transmitted infections: an analysis using the nhanes 1999-2000 data. | factors determining human sexual behaviour are not completely understood, but are important in the context of sexually transmitted disease epidemiology and prevention. being obese is commonly associated with a reduced physical attractiveness but the associations between body mass index, sexual behaviour and the risk of acquiring sexually transmitted infections has never been studied. | 2006 | 16884541 |
| seroprevalence of herpes simplex virus types 1 and 2, epstein-barr virus, and cytomegalovirus in children with acute lymphoblastic leukemia in egypt. | viral infection, especially caused by herpes viruses, is now recognized as an important cause of morbidity and mortality in immunocompromised cancer patients. this study aimed at studying seroprevalence of 3 herpes viruses herpes simplex virus types 1 and 2 (hsv 1 and 2), epstein-barr virus (ebv), and cytomegalovirus (cmv) in children with acute lymphoblastic leukemia (all). | 2006 | 16883441 |
| candidate polyanion microbicides inhibit hiv-1 infection and dissemination pathways in human cervical explants. | heterosexual intercourse remains the major route of hiv-1 transmission worldwide, with almost 5 million new infections occurring each year. women increasingly bear a disproportionate burden of the pandemic, thus there is an urgent need to develop new strategies to reduce hiv-1 transmission that could be controlled by women themselves. the potential of topical microbicides to reduce hiv transmission across mucosal surfaces has been clearly identified, and some agents are currently under evaluatio ... | 2006 | 16882346 |
| detection of chlamydia trachomatis and herpes simplex virus type 1 or 2 in cervical samples in human papilloma virus (hpv)-positive and hpv-negative women. | this study investigated whether the prevalence of human papilloma virus (hpv) in association with chlamydia trachomatis, herpes simplex virus (hsv)-1 and/or hsv-2 was greater in high-grade than in low-grade or control cervical biopsy specimens. hpv-positive (n = 86) and hpv-negative (n = 213) women were screened for hpv, hsv and c. trachomatis by pcr. the most common hpv genotypes were hpv-16, hpv-6 and hpv-33; mixed hpv infection (n = 12) was also seen. a higher prevalence of c. trachomatis, hs ... | 2006 | 16882302 |
| a crucial role for plasmacytoid dendritic cells in antiviral protection by cpg odn-based vaginal microbicide. | topical microbicides represent a promising new approach to preventing hiv and other sexually transmitted infections. tlr agonists are ideal candidates for microbicides, as they trigger a multitude of antiviral genes effective against a broad range of viruses. although vaginal application of cpg oligodeoxynucleotides (odns) and poly i:c has been shown to protect mice from genital herpes infection, the mechanism by which these agents provide protection remains unclear. here, we show that plasmacyt ... | 2006 | 16878177 |
| hiv and other sexually transmitted infections among female sex workers in kinshasa, democratic republic of congo, in 2002. | the objective of this study was to determine the prevalence and risk factors of hiv and other sexually transmitted infections (stis) among female sex workers (fsws) in kinshasa, democratic republic of the congo, in 2002. | 2007 | 16878053 |
| resveratrol suppresses nuclear factor-kappab in herpes simplex virus infected cells. | resveratrol inhibits herpes simplex virus (hsv) replication by an unknown mechanism. previously it was suggested that this inhibition may be mediated through a cellular factor essential for hsv replication [docherty, j.j., fu, m.m., stiffler, b.s., limperos, r.j., pokabla, c.m., delucia, a.l., 1999. resveratrol inhibition of herpes simplex virus replication. antivir. res. 43, 145-155]. after examining numerous cellular factors, we report that resveratrol suppresses nf-kappab (nf-kappab) activati ... | 2006 | 16876885 |
| human cd4+ cd25 high cells suppress proliferative memory lymphocyte responses to herpes simplex virus type 2. | lymphocytes with the regulatory cd4+ cd25+ phenotype frequently suppress memory t-cell responses. murine herpes simplex virus type 1 (hsv-1) models have shown that cd4+ cd25+ cells can limit immunity-mediated corneal damage but slow viral clearance. we investigated the effect of cd4+ cd25+ cells from healthy hsv-2-infected humans on recall proliferative (cd4) responses to hsv-2. depletion and reconstitution experiments were consistent with a suppressive effect of autologous blood-derived cd4+ cd ... | 2006 | 16873284 |
| seroprevalence and correlates of herpes simplex virus type-2 infection in a general gynecology clinic. | up to two-thirds of individuals acquire herpes asymptomatically and most infected persons shed the virus during latency periods. genital infection is frequently associated with the presence of other sexually transmitted diseases. the objective of this paper was to assess the seroprevalence of hsv-2 in a low risk population and to validate the use of reported symptoms and clinical signs as a possible diagnostic tool to screen for hsv-2. | 2007 | 16868756 |
| prevalence and risk factors for herpes simplex virus type 2 antibodies among low- and high-risk populations in indonesia. | objectives/goal: data on prevalence of herpes simplex virus type 2 (hsv-2) infections are limited in asia. this study investigated the seroprevalence of, and risk factors for, antibodies to hsv-2 among low- and high-risk, predominantly asymptomatic populations in indonesia. | 2007 | 16868530 |
| superficial hepatic capsular lesions in a systemically ill young woman. | 2007 | 16868529 | |
| relationship between viral factors, axillary lymph node status and survival in breast cancer. | our previous study based on the results of polymerase chain reaction and southern hybridization for the detection of human papilloma virus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in non-familial breast cancer patients suggest that the viruses associated with breast cancer are hhv-8 > ebv (p < 0.01). therefore, efforts were made to further investigate the association between breast cancer with nodal status and ... | 2007 | 16865407 |
| seroepidemiological study of herpes simplex virus type 2 in patients with the acquired immunodeficiency syndrome in the city of niterói, rio de janeiro, brazil. | this study was designed to determine the seroprevalence of herpes simplex virus type 2 (hsv-2) and to evaluate its association with age, sex as well as other demographic and behavioural factors in 150 human immunodeficiency virus (hiv) positive adults patients attending the general medical outpatient ward for routine care of niterói, state of rio de janeiro, brazil. serum samples were screened for hsv-2 antibodies using an indirect elisa. eighty-three patients were men (mean age: 38.8) and 67 we ... | 2006 | 16862329 |
| sex worker health: san francisco style. | to describe the characteristics of sex workers accessing care at a peer based clinic in san francisco and to evaluate predictors of sexually transmitted infections (sti). | 2006 | 16854996 |
| [the study on the extraction and the antivirus activity of amylose extracted from grateloupia filicina]. | to determine the activity of anti-herpes simplex ii virus (hsv-2) of amylose extracted from grateloupia filicina. | 2006 | 16850725 |
| new information on the risks of hiv transmission in mwanza, tanzania. | 2006 | 16845639 | |
| oral herpes simplex virus type 2 reactivation in hiv-positive and -negative men. | previous studies using viral cultures rarely reported herpes simplex virus type 2 (hsv-2) isolation from the mouth. we sought to characterize oral hsv-2 shedding as detected by hsv dna polymerase chain reaction among hsv-2-seropositive men. | 2006 | 16845624 |
| [determination of herpes simplex virus dna with the use of solid-phase methods for the detection of pcr products]. | to determine dna of herpes simplex virus (hsv), types 1 and 2, the polymerase chain reaction (pcr) method was developed with the subsequent detection of amplification products by means of electrophoresis or the molecular hybridization of nucleic acids (mhna). two variants of mhna have been compared: hybridization in the solution of a biotinylated probe with digoxigenin-labeled pcr with the subsequent sorption of hybridization complexes onto streptavidin-covered plates and solid-phase hybridizati ... | 2006 | 16830598 |
| contribution of interferon-beta to the immune activation induced by double-stranded dna. | introducing double-stranded dna (dsdna) into the cytoplasm of macrophages and dendritic cells triggers the activation of these professional antigen-presenting cells (apcs). this process is characterized by the up-regulation of costimulatory molecules and the production of various cytokines, chemokines, and antibacterial/viral factors. current findings indicate that interferon-beta (ifn-beta) plays a key role in the stimulatory cascade triggered by dsdna. both immune and non-immune cells respond ... | 2006 | 16827891 |
| [natural immunity and herpes infection]. | the review details natural immunological factors that are the first-line protection from herpes simplex virus. these reactions may be conventionally divided into 3 active phases. in phase 1, the virus is attacked by proteins, such as complement of precursors of natural class m (igm) antibodies and antimicrobial peptides. in phase 2, the interferons produced by infected epithelial and resident dendritic cells go into action. and, finally, in phase 3, effector cells, such as neutrophils, macrophag ... | 2006 | 16826749 |
| sequence-based methods for identifying epidemiologically linked herpes simplex virus type 2 strains. | traditional methods for confirming the identity of herpes simplex virus (hsv) isolates use restriction fragment length polymorphism (rflp). however, rflp is less amenable to high-throughput analyses of many samples, and the extent to which small differences in rflp patterns distinguish between different viral strains remains unclear. viral hsv type 2 (hsv-2) dna isolates from 14 persons experiencing a primary hsv-2 infection and from their sexual partners were analyzed by rflp and heteroduplex m ... | 2006 | 16825377 |
| characterization of the ifn-gamma t-cell responses to immediate early antigens in humans with genital herpes. | the ifn-gamma elispot assay has been used to examine the t-cell repertoire for many disease states in humans but, as yet, not genital herpes. using overlapping synthetic peptide libraries, an ifn-gamma elispot assay was established that could measure cd4 and cd8 t-cell responses to hsv-2 antigens in patients with genital herpes. | 2006 | 16822314 |
| developments in herpes simplex virus vaccines: old problems and new challenges. | vaccination has remained the best method for preventing virus spread. the herpes simplex virus (hsv) candidate vaccines tested till now were mostly purified subunit vaccines and/or recombinant envelope glycoproteins (such as gb and gd). in many experiments performed in mice, guinea pigs and rabbits, clear-cut protection against acute virus challenge was demonstrated along with the reduction of the extent of latency, when established in the immunized host. the immunotherapeutic effect of herpes v ... | 2006 | 16821715 |
| antiviral research--19th international conference. 7-11 may 2006, san juan, puerto rico. | 2006 | 16821155 | |
| evaluation of a needle-free delivery platform for prime-boost immunization with dna and modified vaccinia virus ankara vectors expressing herpes simplex virus 2 glycoprotein d. | a previous report described a prime-boost immunization strategy using plasmid and modified vaccinia virus ankara (mva) vectors expressing herpes simplex virus 2 glycoprotein d (gd). enhanced humoral and cellular immune responses were elicited by the prime-boost combination compared to plasmid dna immunization alone. surprisingly, a more diverse antibody isotype response, and a greater antibody and cellular immune response, was obtained if the gd mva vector was used as the priming immunization ra ... | 2006 | 16817767 |
| protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized th1 immune response. | genital herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2) infections are a significant health problem worldwide. while it is believed that cd4+ th1 cells are among the effectors to herpes immunity, developing an epitope-based clinical vaccine capable of inducing an effective anti-herpes cd4+ th1-mediated protection is still under investigation. few molecules achieve this target without the aid of external immuno-adjuvant. the present study was undertaken to examine the immunogenicity in m ... | 2006 | 16817765 |
| new antiviral agents. | during the last three decades, a better understanding of viral replication and disease states caused by viral infections have led to the development of newer antiviral agents with enhanced activity and better tolerability. this review focuses on newer systemic and topical antiviral agents that are used in treatment of herpes viruses including herpes simplex type-1 (hsv-1) and type-2 (hsv-2), varicella-zoster virus (vzv) and cytomegalovirus cmv) as well as the human papilloma virus (hpv). include ... | 2006 | 16816493 |
| valacyclovir prophylaxis to prevent recurrent herpes at delivery: a randomized clinical trial. | to measure the efficacy of valacyclovir suppression in late pregnancy to reduce the incidence of recurrent genital herpes in labor and subsequent cesarean delivery. | 2006 | 16816068 |
| herpes simplex virus us3 protein kinase regulates virus-induced apoptosis in olfactory and vomeronasal chemosensory neurons in vivo. | a role for the us3 protein kinase of herpes simplex virus (hsv) in regulating virus-induced neuronal apoptosis was investigated in an experimental mouse system, in which wild-type hsv invades the central nervous system (cns) via the olfactory and vomeronasal systems upon intranasal infection. wild-type hsv-2 strain 186 infected a fraction of olfactory and vomeronasal chemosensory neurons without inducing apoptosis and was transmitted to the cns, precipitating lethal encephalitis. in sharp contra ... | 2006 | 16815072 |
| maternal herpes simplex virus antibody avidity and risk of neonatal herpes. | the objective of the study was to assess whether herpes simplex virus antibody avidity is associated with risk of transmission of herpes simplex virus to the neonate. | 2006 | 16813750 |
| optimal long-term humoral responses to replication-defective herpes simplex virus require cd21/cd35 complement receptor expression on stromal cells. | replication-defective herpes simplex virus (hsv) strains elicit durable immune responses and protect against virulent hsv challenge in mice, despite being unable to establish latent infection in neuronal cells. mechanisms for generating long-lived immunity in the absence of viral persistence remain uncertain. in animals immunized with replication-defective hsv, durable serum immunoglobulin g (igg) responses were elicited. surprisingly, western blot analyses revealed that the specificities of ant ... | 2006 | 16809316 |
| the epidemiology of hiv-1 infection in northern tanzania: results from a community-based study. | we conducted a community-based study to determine the predictors of hiv-1 among women aged 20-44 years (n = 1,418) and their regular male partners (n = 566) from randomly selected households in moshi, tanzania. the weighted prevalence of hiv-1 was 10.3% in women and 7% in men. the highest risk of hiv-1 was in subjects whose partners were hiv-1 seropositive in both women (adjusted odds ratio (aor) = 26.63; 95% confidence interval (ci): 10.74-66.02) and men (aor = 22.25; 95%ci: 7.06-70.15). herpes ... | 2006 | 16809117 |
| sexually transmitted diseases among patients with human immunodeficiency virus in northern israel. | the co-morbidity of human immunodeficiency virus and other sexually transmitted diseases in israel has not been established. | 2006 | 16805233 |
| management of herpes simplex virus type 2 infection in hiv type 1-infected persons. | human immunodeficiency virus type 1 (hiv-1)-infected persons have high rates of herpes simplex virus type 2 (hsv-2) infection, ranging from 50% to 90% in studies of hiv-infected populations from different parts of the world. genital herpes in persons with hiv type 1 (hiv-1) infection is associated with more-severe and chronic lesions, as well as increased rates of asymptomatic genital shedding of hsv-2. nucleoside analogues (acyclovir, valacyclovir, and famciclovir) decrease the frequency and se ... | 2006 | 16804851 |
| herpes and hiv infection--has the time come to act? | it has been known for some years that the ulcerative and inflammatory stis lead to an increased risk of hiv transmission. in particular, there is a two- to four-fold increased risk of hiv-1 acquisition associated with prevalent herpes simplex virus type 2. the challenges are discussed herein. | 2006 | 16800390 |
| recurrent hsv-2 meningitis in a 9-year-old girl. | while hsv-2 meningitis has been described in prepubertal children in the context of sexual abuse, to the best of our knowledge recurrent episodes have not been described in this population. we report a 9-y-old girl with recurrent hsv-2 meningitis presenting as aseptic meningitis without any evidence of genital herpes. a high index of suspicion for this condition would be needed to make a diagnosis in this age group, which in turn would guide further therapeutic decisions. | 2006 | 16798717 |
| synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. | acyclovir and vidarabine both exhibit anti-herpetic activity. because different mechanisms of action of vidarabine and acyclovir have been reported, we analyzed their combined anti-herpetic activity on plaque formation of herpes simplex virus (hsv)-1, hsv-2, and varicella-zoster virus (vzv) by isobolograms. the results indicate that acyclovir and vidarabine have a synergistic effect on wild type hsv-1, hsv-2, and vzv. the susceptibility of thymidine kinase-deficient hsv-1 to vidarabine was not a ... | 2006 | 16797734 |
| real-time pcr for detection of herpes simplex virus without nucleic acid extraction. | the speed and sensitivity of real-time polymerase chain reaction (pcr) have made it a popular method for the detection of microbiological agents in both research and clinical specimens. for the detection and genotyping of herpes simplex virus (hsv) in clinical specimens, real-time pcr has proven to be faster, more sensitive and safer than earlier methods which included isolation of the virus in cell culture followed by immunofluorescence microscopy. while pcr-based assays for hsv detection posse ... | 2006 | 16796763 |
| properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene: mechanisms of reversion to a thymidine kinase-negative phenotype. | we have isolated cells with a thymidine kinase-negative (tk(-)) phenotype from cells which carry the herpes simplex virus type 2 tk gene by selection in 5-bromodeoxyuridine or 9-(2-hydroxyethoxymethyl)guanine. both selection routines generated revertants with a frequency of 10(-3) to 10(-4), and resistance to either compound conferred simultaneous resistance to the other. tk(-) revertants fell into three classes: (i) cells that arose by deletion of all virus sequences, (ii) cells that had lost t ... | 1980 | 16789205 |
| empirical observations underestimate the proportion of human immunodeficiency virus infections attributable to sexually transmitted diseases in the mwanza and rakai sexually transmitted disease treatment trials: simulation results. | population attributable fractions (paf) from observational studies may under- or overestimate the contribution of cofactor sexually transmitted disease (std) to human immunodeficiency virus (hiv) spread. empirical paf estimates from the mwanza and rakai trials indicated the proportion of hiv infections attributable to stds was higher in mwanza than rakai. | 2006 | 16778738 |
| the synergistic effect of ifn-alpha and ifn-gamma against hsv-2 replication in vero cells is not interfered by the plant antiviral 1-cinnamoyl-3, 11-dihydroxymeliacarpin. | recent studies have shown that gamma interferon (ifn-gamma) synergizes with ifn-alpha/beta to inhibit herpes simplex virus type 1 (hsv-1) replication in vitro. since ifn response represents an early host defense event against viral infection and the fact that treatment with meliacine, a plant antiviral, ameliorate the severity of the herpetic infection in female mice infected intravaginally with hsv-2, we wanted to investigate whether the administration of meliacine to hsv-2 infected mice could ... | 2006 | 16772029 |
| high hiv sexual risk behaviors and sexually transmitted disease prevalence among injection drug users in northern vietnam: implications for a generalized hiv epidemic. | hiv prevalence in vietnam is currently concentrated among injection drug users (idus). the extent to which this core risk group represents a potential for broader hiv transmission to the general population is currently unknown. | 2006 | 16763499 |
| epitope mapping of full-length glycoprotein d from hsv-2 reveals a novel cd4+ ctl epitope located at the transmembrane-cytoplasmic junction. | the glycoprotein d of hsv-2 (gd2) is currently a leading candidate vaccine target for genital herpes vaccines as both cellular and humoral responses can be generated against it. however, little is known about how vaccine composition will affect t cell epitope selection. a panel of 15-mer peptides (with 11 amino acid overlap) spanning full-length gd2 was used to investigate the fine specificity of t cell responses to gd2 as well as the role of vaccine composition on epitope selection. spleen cell ... | 2006 | 16762332 |
| mature glycoprotein g presents high performance in diagnosing herpes simplex virus type 2 infection in sera of different tanzanian cohorts. | herpes simplex virus type 2 (hsv-2) is a common sexually transmitted infection in sub-saharan africa. glycoprotein g (gg) of hsv-2 elicits a type-specific antibody response and is widely used for serodiagnosis. gg is cleaved into a secreted portion (sgg-2) and a highly o-glycosylated mature portion (mgg-2). the performances of these two native immunosorbent purified antigens were compared in an enzyme-linked immunosorbent assay (elisa) format with a commercially available assay (focus2) using se ... | 2006 | 16760320 |
| synthesis and biological evaluation of carboacyclic nucleosides with (z) and (e)-9-[4,4-bis(hydroxymethyl)]-2-butenyl side chain. | a series of carboacyclic nucleosides with (z) and (e)-9-[4,4-bis(hydroxy-methyl)]-2-butenyl side chains were synthesized as ring open analogs of cyclohexene nucleosides 1 and bioisosteres of ganciclovir 3. the (e)-isomers were obtained to compare the side chain geometry effect on antiviral activity. | 2006 | 16759867 |
| comparison of immunoassays for differentiation of herpes simplex virus type 1 and 2 antibodies. | to asses the commercial available enzyme-linked immunosorbent assays (elisa) for differentiation of herpes simplex virus type 1 (hsv-1) and type 2 (hsv-2) antibodies. | 2006 | 16758036 |
| gender differences in the prevalence of sexually transmitted infections and genital symptoms in an urban setting in southern india. | to examine gender differences in sexual behaviour, the prevalence of laboratory-detected sexually transmitted infections (stis) and self-reported genital symptoms in urban chennai, tamil nadu, india. | 2006 | 16757513 |
| mollaret's meningitis. | 2006 | 16754896 | |
| knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition. | prospective studies of herpes simplex virus type 2 (hsv-2) infection in discordant couples have shown a low rate of transmission. however, unlike partners with genital herpes in prospectively monitored couples, most persons who transmit genital herpes are not aware of having the infection. | 2006 | 16741881 |
| neonatal herpes simplex virus infections in canada: results of a 3-year national prospective study. | the goal was to determine incidence, determinants, and morbidity and mortality rates of neonatal herpes simplex virus infections in canada. | 2006 | 16740836 |
| vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission. | microbicides must protect against std pathogens without causing unacceptable toxic effects. microbicides based on nonoxynol-9 (n9) and other detergents disrupt sperm, hsv and hiv membranes, and these agents are effective contraceptives. but paradoxically n9 fails to protect women against hiv and other std pathogens, most likely because it causes toxic effects that increase susceptibility. the mouse hsv-2 vaginal transmission model reported here: (a) directly tests for toxic effects that increase ... | 2006 | 16740164 |
| consistent use of condoms lowers the risk of infection with type 2 herpes virus. | 2006 | 16739292 | |
| an atypical herpetic vulval ulcer in an african woman: an important lesson. | a 43-year-old woman from southern africa presented with an eight-month history of a painless vulval ulcer. she did not have any relevant past medical or drug history. she had never had, or ever been offered an hiv antibody test despite being from an endemic region. on examination, there was an ulcer on her right labia and a painless right inguinal lymph node. herpes simplex virus (hsv) type 2 culture was positive. the hiv antibody test was also positive. other cultures and serology including syp ... | 2006 | 16734971 |
| seroprevalence of hsv-1 and 2 among sex workers attending a sexually transmitted infection clinic in singapore. | we studied the seroprevalence of herpes simplex virus (hsv)-1 and 2 in sex workers attending a sexually transmitted infection clinic in singapore and examined their knowledge and attitudes towards hsv infection. a total of 300 participants were recruited. questionnaires were administered and blood was taken and analysed, using the herpeselect 1 and 2 elisa igg assays (type-specific serological test). hsv-1 serology was positive in 230 (76.7%), negative in 67 (22.3%) sex workers and indeterminate ... | 2006 | 16734962 |
| case report: symptomatic oral herpes simplex virus type 2 and asymptomatic genital shedding. | a 42-year-old bisexual man with a history of recurrent oral herpes and no history of genital herpes was noted to have antibody to herpes simplex virus type 2 (hsv-2) only. during a symptomatic oral recurrence, hsv-2 was found in a perioral lesion as well as in the genital area. | 2006 | 16733000 |
| increase in rates of herpes simplex virus type 1 as a cause of anogenital herpes in western sydney, australia, between 1979 and 2003. | recent studies suggest that herpes simplex virus type 1 (hsv-1) is becoming more common as a cause for genital herpes, relative to hsv-2. we aimed to calculate trends in hsv type from isolates and serology samples sent to a reference virology laboratory in new south wales (nsw), australia. | 2006 | 16731681 |
| genital hsv-1 infections. | 2006 | 16731663 | |
| antiviral flavans from the leaves of pithecellobium clypearia. | two new antiviral flavan derivatives were isolated from a methanol extract of leaves of pithecellobium clypearia as guided by antiviral assays. the structures were characterized, by spectroscopic analyses, as 7-o-galloyltricetifavan (1) and 7,4'-di-o-galloyltricetifavan (2). cytopathic effect (cpe) reduction assay showed that both compounds 1 and 2 possess antiviral activity against respiratory syncytial virus (rsv), with 50% inhibition concentration (ic(50)) values of 5 and 10 microg/ml, respec ... | 2006 | 16724853 |