Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| the effect of benzoyl peroxide on cutaneous micro-organisms in vitro. | the survival curves of cutaneous micro-organisms in the presence of benzoyl peroxide were investigated. all the curves exhibited a shoulder prior to exponential cell death. benzoyl peroxide was lethal to the cutaneous organisms tested and they varied in sensitivity increasing as follows: propionibacterium acnes, staphylococcus capitis, staph. epidermidis, staph. hominis, prop. avidum, prop. granulosum and pityrosporum ovale. | 1983 | 6874624 |
| new antibiotic, isohematinic acid. ii. physico-chemical properties, structural elucidation and biological activities. | physico-chemical characterization of isohematinic acid revealed that this antibiotic has a succinimide nucleus. from elemental analysis, the molecular formula of isohematinic acid was determined to be c8h9no4. isohematinic acid showed weak antimicrobial activities against anaerobic bacteria, such as bacteroides fragilis and propionibacterium acnes. | 1983 | 6874567 |
| augmentation of nk activity by corynebacterium parvum fractions in vivo and in vitro. | biochemically modified whole cell preparations and derived fractions of corynebacterium parvum (c. parvum) were evaluated for the ability to augment natural killer cell cytoxicity in vivo and in vitro in rats. unfractionated c. parvum enhanced peritoneal cell (pc) nk activity in a dose dependent fashion. this activity appeared to be enriched in insoluble light residue material obtained from hot phenol water extraction. enhancement of pc cytotoxicity was significantly greater at all time points t ... | 1983 | 6874167 |
| platelet activating factor (paf) induces the oxidative burst in macrophages. | the response of guinea pig peritoneal macrophages to platelet activating factor (1-o-octadecyl-2-acetyl-sn-glycero-3-phosphoryl-choline) was examined. in corynebacterium parvum induced macrophages, platelet activating factor, over a wide dose range (3.8 x 10(-5) to 3.8 x 10(-9)m) triggered the oxidative burst as indicated by increased luminol-dependent chemiluminescence and hydrogen peroxide release into culture supernatants. this effect of paf was inhibited by superoxide dismutase and catalase. ... | 1983 | 6874164 |
| leishmania tropica major in mice: vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility. | balb/c and balb/c.h-2b mice are genetically susceptible to development of persistent and severe disease following cutaneous injection of promastigotes of the protozoan parasite, leishmania tropica major, whereas c57bl/6 are relatively resistant. resistance in c57bl/6 can be further increased by intraperitoneal injection of living, but not killed, promastigotes prior to cutaneous challenge. severely diseased balb/c mice can show resistance to development of a second cutaneous lesion but apparentl ... | 1983 | 6870673 |
| bacteriological study in chronic maxillary sinusitis. | the bacterial findings of 73 maxillary sinuses in 48 patients with chronic maxillary sinusitis, together with 7 non-inflamed sinuses, are reported. employing an intraoperative technique and simultaneous collection of 3 different types of specimens in the present investigation made possible comparison of their bacterial characteristics. the results indicated that intraoperative culture of antral mucosa seems to provide the most reliable finding of bacterial flora in chronic maxillary sinusitis. t ... | 1983 | 6865629 |
| protection of mice against influenza virus infection: enhancement of nonspecific cellular responses by corynebacterium parvum. | groups of c57bl/6j, balb/c, balb/c, nu+/nu+ mice, inoculated intranasally with corynebacterium parvum (350 micrograms/mouse) were protected from death by an otherwise lethal dose of influenza virus, a/wsn (h1n1) inoculated 3 days later. the lungs of c. parvum-treated, virus-infected c57bl/6j, balb/c, or balb/c nu+/nu+ mice contained significantly less infectious virus than did controls, and this reduction was apparent as soon as 24 hr after virus inoculation. the maximum protective effect correl ... | 1983 | 6861206 |
| propionibacterium shunt nephritis in two adolescents with medulloblastoma. | the anaerobic diphtheroid propionibacterium acnes was identified as the organism responsible for "shunt" nephritis in two adolescents with ventriculoatrial shunts inserted previously for the management of medulloblastoma. only three cases of "shunt" nephritis secondary to infection with this common skin commensal organism are known to have been reported. the rarity of such reports may be related to the lack of good anaerobic laboratories, the length of time necessary for cultures to show growth, ... | 1983 | 6861076 |
| enhanced fc receptor expression by a sub-population of murine intra-tumour macrophages following intravenous corynebacterium parvum therapy. | intravenous injection of corynebacterium parvum (c. parvum) 4 days after s.c. inoculation of 5 x 10(5) cells derived from the immunogenic fibrosarcoma fsa/r induced tumour growth inhibition over a period of 21 days in syngeneic c3h/buf mice. this was not accompanied by a change in the proportions of host cells within the tumour, but the activation state of tumour-infiltrating macrophages was increased following c. parvum therapy. two macrophage subpopulations were identified in fsa/r tumours aft ... | 1983 | 6860547 |
| enhancement of tumor metastasis and suppression of natural killer cell activity by beta-estradiol treatment. | treatment of mice with 17 beta-estradiol leads to a selective inhibition of natural killer (nk) cell activity as measured by in vitro cytotoxicity against yac-1 lymphoma and uv-2237 fibrosarcoma target cells. activation of nk cells by polyinosinic-polycytidylic acid (poly i.c) and corynebacterium parvum also was impaired in beta-estradiol-treated mice, whereas activation of tumoricidal macrophages was uncompromised. the beta-estradiol-induced suppression of nk cell activity was associated with a ... | 1983 | 6848604 |
| immunopotentiation of cell-mediated hypersensitivity by corynebacterium parvum (propionibacterium acnes). | we have investigated the activity of local corynebacterium parvum (propionibacterium acnes) as an immunopotentiator of allergic contact dermatitis (acd) and photo-acd in rodents. c. parvum given into the sensitization site, but not at a distance, increased the delayed-type hypersensitivity to the chemical allergen. an immunoadjuvant effect could be realized even when c. parvum was given several days after allergen; it was readily obtained in b cell-deficient mice. cyclophosphamide pretreatment h ... | 1983 | 6848475 |
| inhibition of hepatic drug metabolism in the rat after corynebacterium parvum treatment. | drug-metabolizing enzyme activities, cytochrome concentration, and protein content of hepatic microsomal preparations from adult, female sprague-dawley rats were examined at 1-, 3-, 6-, 10-, 14- and 17-day intervals after administration of a single intravenous injection of corynebacterium parvum (c. parvum) at a dose of 10 mg/m2. aniline hydroxylase (ah) activity, aminopyrine demethylase (apd) activity, and cytochrome p-450 concentration were reduced 20-50% on days 3-6 and, thereafter, gradually ... | 1983 | 6847717 |
| an unusual cause of bacterial meningitis in the elderly. propionibacterium acnes. | 1983 | 6847449 | |
| intrapleural corynebacterium parvum for malignant pleural effusions. | a pilot study of topical (intrapleural) treatment with corynebacterium parvum was carried out in 10 patients with malignant pleural effusions complicating primary or secondary neoplasms and necessitating frequent thoracocentesis for symptomatic relief. the method was aspiration of all intrapleural fluid except a small portion left for dilution, and then injection of 7 mg of a preparation of corynebacterium parvum suspended in 20 ml of normal saline solution. the treatment was repeated in each ca ... | 1983 | 6845257 |
| susceptibility of propionibacterium acnes clinical isolates to 22 antimicrobial agents. | susceptibilities of 104 propionibacterium acnes isolates to each of 22 antimicrobial agents was evaluated by broth microdilution. these isolates were susceptible to all of the test agents except metronidazole. n-formimidoyl thienamycin, a penem coded sch 29482, and penicillin ranked first, second, and third, respectively, in activity and were significantly more active than other penicillins, cephalosporins, tetracyclines, clindamycin, or chloramphenicol. | 1983 | 6838191 |
| role of reduced sulfur compounds in nutrition of propionibacterium acnes. | in a study of the nutritional requirements of propionibacterium acnes, acid hydrolyzed casein was shown to be the preferred nitrogen source in a glycerol-salts medium. of 22 individual amino acids tested, only cysteine supported growth in the glycerol-salts medium. this indicated a requirement not only for amino nitrogen but also for reduced sulfur. in the presence of an auxiliary nitrogen source, thioglycolate or thiosulfate could replace sulfur-containing amino acids. the apparent requirement ... | 1983 | 6833481 |
| enhancement of natural resistance to influenza virus in lipopolysaccharide-responsive and -nonresponsive mice by propionibacterium acnes. | lipopolysaccharide-responsive c3h/hen mice were rendered resistant to a mouse-adapted strain of influenza (aichi, h(3)n(2)) virus when propionibacterium acnes was given either intranasally or intraperitoneally several days before virus infection. the time of p. acnes treatment was important since no protection was demonstrated when this agent was given either on the same day as or several days after virus challenge. in contrast, lipopolysaccharide-nonresponsive c3h/hej mice were not protected wh ... | 1983 | 6832817 |
| production, purification, and properties of a bacteriocin from staphylococcus aureus isolated from saliva. | staphylococci from samples of human saliva were isolated on staphylococcal-selective agar plates. these strains were tested for the inhibition of the growth of staphylococcus aureus fda209p. the frequency of inhibitory strains among all of the staphylococcal isolates was 5.2%. strain iys2, which formed the biggest inhibitory zone against the growth of the indicator strain, was used as the producer of bacteriocin. iys2 was identified to be s. aureus, based on its biological properties. the bacter ... | 1983 | 6832811 |
| evidence for granulocyte-mediated macrophage activation after c. parvum immunization. | it has been previously demonstrated that at the peak of the peritoneal response to corynebacterium parvum (day 4), cytolytic macrophages can be characterized by the presence of intracellular bacteria. in the present study, the role of neutrophils in the activation of peritoneal macrophages by c. parvum was investigated. inflammatory neutrophils isolated 5 hr after ip administration of c. parvum were transferred to normal, syngeneic mice and the peritoneal macrophages of recipients harvested 4 da ... | 1983 | 6831566 |
| isolation, identification, and synthesis of 2,3-diamino-2,3-dideoxyglucuronic acid: a component of propionibacterium acnes cell wall polysaccharide. | a previously undescribed component of the cell wall polysaccharide of propionibacterium acnes, 2,3-diamino-2,3-dideoxyglucuronic acid, has been identified and synthesized. the component occurs to the extent of about 3 to 5% in the wall polysaccharides of p. acnes types i and ii and in propionibacterium avidum types i and ii; it also appears to be present, but in much smaller amounts, in the cell wall of propionibacterium granulosum. | 1983 | 6826525 |
| new group of prostaglandin-like compounds in p. acnes. | 1983 | 6826037 | |
| inefficacy of sc corynebacterium parvum in stage i malignant melanoma: preliminary results of a single-institution pilot study. | 1983 | 6825130 | |
| intraperitoneal immunotherapy of human ovarian carcinoma with corynebacterium parvum. | corynebacterium parvum has been administered i.p. to 14 patients with advanced ovarian cancer. two patients had responded completely to cytoreductive surgery and combination chemotherapy prior to immunotherapy, and one patient with residual disease had received only a single course of c. parvum due to i.p. catheter malfunction. among the 11 patients with residual disease evaluable for response, from three to eight i.p. treatments with c. parvum produced surgically confirmed tumor regression in f ... | 1983 | 6825108 |
| improved survival after pneumococcus in splenectomized and nonsplenectomized mice with corynebacterium parvum. | splenectomy increases the susceptibility to infections with certain bacteria, particularly streptococcus pneumoniae. because the immunomodulator corynebacterium parvum expands the phagocytic cell compartment and enhances reticuloendothelial function, we tested the effect of c parvum in mice challenged with aerosolized pneumococci. mice splenectomized seven days before pneumococcal challenge and treated intraperitoneally with 700 micrograms of c parvum immediately after exposure were protected wh ... | 1983 | 6824432 |
| dose-dependent macrophage stimulation by corynebacterium parvum. | corynebacterium parvum (c. parvum) administered at a dose of either 0.1, 1 or 10 mg/kg intraperitoneally (ip) to bdf1 mice was evaluated for its influence on peritoneal exudate cell differentials, numbers, respiration, phagocytic activity and capacity and intracellular microbicidal activity. the ip administration of 1 mg/kg of c. parvum resulted in a 2-3 fold increase in the yield of peritoneal exudate cells 1-5 days after injection; 0.1 mg/kg was ineffective, while 10 mg/kg of c. parvum manifes ... | 1980 | 6821558 |
| cytostatic effects of activated macrophages on tumor target cells: inhibition of cytotoxic action of ara-c. | studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with corynebacterium parvum revealed that their effect on the emt-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. in additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on emt-6 target cells. | 1980 | 6821557 |
| [antimicrobial action of benzoyl peroxide]. | 1982 | 6821331 | |
| regulatory interactions between macrophages and t-cell subsets in listeria monocytogenes-specific t-cell activation. | peritoneal exudate t lymphocytes from listeria monocytogenes-immune mice in the presence of the homologous antigen (heat-killed l. monocytogenes) and normal macrophages showed l. monocytogenes-specific proliferative responses. proliferation was inhibited by macrophages from l. monocytogenes- or corynebacterium parvum-pretreated mice as well as by exogenous prostaglandin e(2). macrophage-dependent inhibition of t-cell proliferation-at least in part-could be reversed by addition of indomethacin. w ... | 1982 | 6818150 |
| structures and biological activities of peptidoglycans of listeria monocytogenes and propionibacterium acnes. | the cell-wall skeletons of listeria monocytogenes strain egd and propionibacterium acnes strain c7, which have the ability to induce macrophage activation, were analyzed, and the structures of the peptidoglycans were investigated. the analytical data indicate that both peptidoglycans have glucosamine residues with free amino groups, which are responsible for the resistance to lysozyme. possible structures of these peptidoglycans were deduced from the composition and the results of determination ... | 1982 | 6811573 |
| activation of components of the alternative pathway of complement by propionibacterium acnes cell wall carbohydrate. | the trichloroacetic acid (tca) extractable molecules in propionibacterium acnes cell wall were tested for the ability to activate the alternative pathway of complement in human serum treated with ethyleneglycol-bis (beta-aminoethyl ether) n,n-tetracetic acid (egta). the extracted molecules failed to consume hemolytic activity against antibody-coated sheep erythrocytes but gave a dose-dependent consumption of rabbit erythrocyte (re) lytic activity. similarly, the extract produced significant clea ... | 1982 | 6809840 |
| nonspecific resistance to infection expressed within the peyer's patches of the small intestine. | intraperitoneal or intraduodenal pretreatment of mice with dead corynebacterium parvum failed to produce significant nonspecific resistance to salmonella enteritidis infection in the peyer's patches of the small intestine. however, mice pretreated with a single oral infection of live listeria monocytogenes were capable of restricting the growth of s. enteritidis in the peyer's patches. the ability of l. monocytogenes to induce nonspecific resistance was associated with the ability of this organi ... | 1982 | 6809636 |
| dispersal of non-sporeforming anaerobic bacteria from the skin. | dispersal of non-sporeforming anaerobic bacteria was studied. skin samples were taken from the subjects, and dispersed from different parts of the body was examined. the number of anaerobic bacteria dispersed was not correlated to their density on the surface of skin area exposed. the highest density of anaerobic bacteria on the skin was found in the face and upper trunk, but the highest yield of anaerobic bacteria dispersed came from the lower trunk. the dominant anaerobic bacteria dispersed we ... | 1982 | 6806353 |
| analysis of the soluble cytoplasmic components of mycobacteria and nocardia by crossed immunoelectrofocusing. | soluble cytoplasmic components of mycobacterium tuberculosis, strain h 37 ra, and washington ii, mycobacterium bovis, strain bcg and nocardia asteroides were analysed by isoelectric focusing, crossed immunoelectrophoresis, and crossed immunoelectrofocusing. using con a-affinity chromatography con a-reactive polysaccharides could be separated from the cytoplasmic fraction which improved the focusing effect. the isoelectric focusing patterns of the various mycobacterial strains were similar, howev ... | 1982 | 6805157 |
| regulation of arachidonic acid metabolism by macrophage activation. | levels of zymosan-induced arachidonic acid (20:4) metabolism by peritoneal macrophages elicited with inflammatory agents and resident macrophages were similar. thyioglycollate (thio)-elicited macrophages represented the exception; however, the diminished metabolism by these cells was reproduced by exposing resident cells to 5 mg/ml thio broth in vitro. in contrast, reduced prostaglandin synthesis by macrophages from mice variously treated with the immunologic agents, corynebacterium parvum or ba ... | 1982 | 6801185 |
| resting macrophages produce distinct metabolites from exogenous arachidonic acid. | resident mouse peritoneal macrophages rapidly metabolize free arachidonic acid (20:4) in the absence of a discernible trigger. after a 20-min incubation in serumless medium, one-third of the fatty acid was found esterified in cell phospholipid and two-thirds was metabolized to oxygenated products which were recovered in the culture medium. the 20:4 oxygenated metabolites were identified by reverse-phase high performance liquid chromatography as hydroxyeicosatetraenoic acids (hetes) and 6-keto pr ... | 1982 | 6799609 |
| [inhibitory effect of arginine butyrate on the development of crocker 180/tg tumor in swiss mice]. | arginine butyrate slightly increases the resistance of swiss mice to allografted 180/tg tumor cells. a single injection of corynebacterium parvum has comparable effects. however, it they are associated, survival rate is significantly augmented. | 1981 | 6797689 |
| [effect of the age of the mouse on the action of corynebacterium parvum in inhibiting the growth of 2 syngenetic tumors]. | the antitumor properties of corynebacterium parvum have been studied in mice of different ages of two inbred strains: xvii mice and c3h mice grafted with syngeneic tumors. the antitumor protection was very weak in young mice: no effect on mortality rate, only an increase in mean survival time was observed. the highest level of protection was obtained in 2-5 month old mice (100% of survival) in aged mice this antitumor protection decreases more rapidly in c3h mice than in xvii mice. it is interes ... | 1981 | 6794870 |
| prostaglandins and host defense in cancer. | 1981 | 6792432 | |
| phagocytic and chemiluminescent responses of mouse peritoneal macrophages to living and killed salmonella typhimurium and other bacteria. | in the presence of luminol, resident as well as thioglycolate-induced and immunized macrophages emitted chemiluminescence more efficiently when the cells were exposed to living salmonella typhimurium than when they were exposed to the same bacterium killed by ultraviolet light or heat. this phenomenon was observed whether or not the bacterium was opsonized. the different response to living and killed bacteria was also found with escherichia coli, pseudomonas aeruginosa, proteus morganii, and ent ... | 1981 | 6788707 |
| in vitro cytotoxicity expressed by cells active against established tumors in vivo. | although antitumor activity by host cells has been documented in vivo and in vitro, the cellular relationships between these two classes of studies are not clear. cells capable of causing the regression of solid tumors are generated in lymph nodes draining sites of immunization with corynebacterium parvum:irradiated p815 mastocytoma admixtures. these cells are active in a 51cr release assay at a low effector:target ratio producing a characteristic low level of specific 51cr release which require ... | 1981 | 6788359 |
| inhibition of lipase production in propionibacterium acnes by sub-minimal-inhibitory concentrations of tetracycline and erythromycin. | 1981 | 6786318 | |
| [immunomodulators]. | a comprehensive picture of the most well-known immunomodulators has been drawn, focussing the attention on their immunopharmacological profile and their prospective clinical use. besides, the cell targets of the immunologically active agents are also considered. the role of cyclic nucleotides in the mechanisms of immune regulation as well as the importance of the host characteristics in this connection are carefully analyzed. some general considerations are finally set forth on the usefulness of ... | 1980 | 6779825 |
| kinetic parameters of lactate dehydrogenases of some rumen bacterial species, the anaerobic ciliate isotricha prostoma and mixed rumen microorganisms. | a number of kinetic parameters of the lactate dehydrogenases of three rumen bacterial species (peptostreptococcus productus, propionibacterium acnes and actinomyces viscosus), the rumen ciliate isotricha prostoma and mixed rumen microorganisms (mrm) with respect to nadh, pyruvate, fructose-1,6-diphosphate (fdp) as well as the effects of several nucleotide phosphates were studied. partially purified ldh of peptostr. productus had the same kinetic parameters as in crude cell free extracts. values ... | 1980 | 6778389 |
| microbiology of otitis media. | the microbiology of otitis media (om) has been documented by cultures of middle ear fluid (mef) obtained by needle aspiration. the results of studies of bacteriology of om from sweden, finland and the united states are very similar: streptococcus pneumoniae and haemophilus influenzae are the most important pathogens: gram-negative enteric bacilli are isolated from mef of approximately equal to 20% of infants to six weeks of age but are rarely present in mef of older children; group a beta hemoly ... | 1980 | 6778362 |
| antibody coated bacteria in otitis media with effusions. | the significance of bacterial isolates of coagulase negative staphylococcus epidermidis and corynebacterium species in middle ear fluids remains controversial. this study was undertaken to evaluate the possible role of these organisms in different effusions. cultures were obtained from the external cartilaginous ear, bony canal, tympanic membrane, middle ear fluids, tonsils and nasopharynx of 93 patients at the time of myringotomy for otitis media with effusion. isolates of coagulase negative st ... | 1980 | 6778287 |
| the effects of corynebacterium parvum in dogs and a study of its distribution following intravenous injection. | 1980 | 6777166 | |
| differentiation and production of colony-stimulating factor induced by immunostimulants in a leukemia cell line. | immunostimulants from various microorganisms were tested on a myeloid leukemia cell line (m1) for the ability to induce production of csf and to cause differentiation of these cells. based on their activities, the compounds were divided into two general classes: those inducing extensive cellular differentiation and those devoid of this effect. the stimulants which were active in this regard always produced large quantities of csf, whereas those devoid of a differentiating effect did not cause cs ... | 1980 | 6776132 |
| relationship between non-specific activity of macrophages and immune responses to listeria monocytogenes. | delayed footpad reactions and acquired cellular resistance to listeria monocytogenes were studied in mice whose mononuclear phagocyte system (mps) had been blocked or stimulated. colloidal carbon was used for the blockade of mps and corynebacterium parvum used for the stimulation. strong delayed footpad reactions. on the other hand, the i.v. injection of 3 x 10(1) listeria induced an appreciable level mice, while in mps-stimulated mice, i.v. injection with even 4 x 10(3) listeria could not induc ... | 1980 | 6776031 |
| immunotherapy of the guinea pig line 10 hepatocarcinoma with a variety of nonviable bacteria. | a variety of heat-killed bacteria were tested for their capacity to induce regressions of established line 10 hepatocarcinomas in syngeneic guinea pigs. multiple intralesional injections of heat-killed escherichia coli, streptococcus mutans, listeria monocytogenes, and propionibacterium acnes resulted in complete regression of the tumor in a majority of guinea pigs. repeated injections of heat-killed mycobacterium bovis strain bacillus calmette-guérin caused no regressions. surviving animals wer ... | 1980 | 6775802 |
| mycotic aneurysm of the pulmonary artery complicating ventriculoatrial shunt. | 1980 | 6773348 | |
| the use of immunopotentiators in malaria. | 1980 | 6772589 | |
| [metronidazole sensitivity of anaerobes. a comparison with other chemotherapeutics (author's transl)]. | in comparative in vitro studies, broad spectrum penicillins and cephalosporins showed a relatively weak action in the range of beta-lactamase-positive bacteroides species (b. fragilis, b. thetaiotamicron) bacteroidaceae activity being otherwise good. clindamycin was more effective against bacteroides species than against bacteria of the fusobacterium-sphaerophorus group. metronidazole, however, showed no gap in its efficacy against bacteroidaceae, peptococcaceae and clostridium spp. with the exc ... | 1980 | 6771559 |
| decreased resistance to listeria monocytogenes in mice injected with killed corynebacterium parvum: association with suppression of cell-mediated immunity. | to investigate the therapeutic potential of killed corynebacterium parvum, its effects on the course of listeria monocytogenes infection in mice was studied. mortality in mice given c. parvum after l. monocytogenes infection was greater than in mice given c. parvum before infection or infected with only l. monocytogenes. c. parvum alone resulted in no mortality. spleens from infected mice given c. parvum had increased numbers of l. monocytogenes. peritoneal macrophages from mice infected with on ... | 1980 | 6767792 |
| [numerical taxonomy of gram-positive anaerobic bacilli]. | numerical taxonomy's techniques were employed on twenty one anaerobic gram positive bacilli strains taking account of eighty morphologic and biochemical features. two methods of coding (weighted and non weighted) and four clustering methods (unweighted pair-group method using arithmetic averages; weighted pair-group method using arithmetic averages; single linkage and complete linkage) were used. eight dendrograms were obtained and they showed that c. haemolyticum (strains 1, 2, 4, 7); c. subter ... | 1982 | 6765620 |
| effects of corynebacterium parvum on escherichia coli infection in mice. | the contribution of activated macrophages to protection against escherichia coli was studied in mice. mice treated intraperitoneally with killed corynebacterium parvum organisms 1 d prior to challenge showed an increased resistance to intraperitoneal infection with e. coli; the predominant leucocytes in the peritoneal cavity of these animals were polymorphonuclear cells. however, treatment with c. parvum 4 d prior to challenge induced mainly activated macrophages in the peritoneal cavity and hos ... | 1982 | 6763935 |
| shunt nephritis associated with propionibacterium acnes with demonstration of the antigen in the glomeruli. | 1982 | 6762506 | |
| antitumor effect of heat-killed aspergillus fumigatus mycelium in a mouse model. | a suspension of heat-killed aspergillus fumigatus mycelium inhibited the growth of a chemically-induced mouse bladder tumor (mbt). tumor growth was inhibited when the mycelium was injected into mice in a mixture with the tumor cells, when injected into growing tumors, and when introduced ip at the time tumor cells were injected into the hind leg muscle. in the concentrations that affected tumor growth no toxicity of the fungus preparation was observed. the fungal suspension was more effective ag ... | 1982 | 6760960 |
| a cell surface marker expressed on cytotoxic peritoneal macrophages and normal lung macrophages. | 1982 | 6760695 | |
| [clinical effectiveness and immunological control of the immunochemotherapy of acute leukemia in children using a corynebacterium parvum preparation]. | 1982 | 6760108 | |
| maintenance of the normal flora of human skin grafts transplanted to mice. | full-thickness human cadaver skin was maintained on the dorso-lateral thoracic region of hairless mice whose immune rejection mechanism was suppressed using anti-mouse-thymocyte globulin. the bacterial profile of the pregrafted skin did not differ significantly from the normal human microflora. in contrast, the murine skin exhibited quantitative and qualitative differences from the human flora, in particular by the complete absence of propionibacterium acnes, the dominant bacterium on sebum-rich ... | 1982 | 6759614 |
| histologic observations of coccoid forms suggestive of cell wall deficient bacteria in cutaneous and systemic lupus erythematosus. | the cutaneous lesions of seven consecutive patients with cutaneous lupus erythematosus (le), two patients with systemic le, and a patient with both dermatomyositis and cutaneous le, were studied bacteriologically and microscopically for the presence of bacteria. the study was prompted by the previous reports of variably acid-fast and non-acid-fast bacteria in other collagen diseases, and also by recent reports confirming the presence of cell wall deficient (cwd) bacteria (staphylococci, streptoc ... | 1982 | 6759425 |
| bacteriologic and serologic investigation in diffuse sclerosing osteomyelitis (dso) of the mandible. | an attempt was made to clarify the obscure origin of diffuse sclerosing osteomyelitis (dso) of the mandible. bacteriologic investigations of specimens from diseased mandibles were performed with special attention to anaerobic culture technique. propionibacterium acnes and peptostreptococcus intermedius were in some patients found to be of etiologic importance. sampling techniques and associated problems are discussed. an examination was made for antibodies in the patients' sera against antigens ... | 1982 | 6757825 |
| comparative aspects of cancer immunotherapy: immunologic methods used for treatment of spontaneous cancer in animals. | 1982 | 6757216 | |
| methotrexate alone or with regional subcutaneous corynebacterium parvum in the treatment of recurrent and metastatic squamous cancer of the head and neck. | patients with advanced, incurable squamous cancer of the head and neck were randomly assigned to treatment with weekly methotrexate alone or methotrexate with corynebacterium parvum given subcutaneously in weekly bilateral doses in sites around the neck. the addition of c. parvum did not alter the response rate, response duration, survival (either median or long-term) or severity of toxic effects compared to treatment with methotrexate alone. response rates were higher for patients without dista ... | 1982 | 6754063 |
| development of a bioassay for anti tumor activity of biological response modifiers of the reticuloendothelial stimulant class: reproducibility of the bioassay. | intravenously administered diluzio glucan, wellcome c. parvum, and glaxo bcg caused dose dependent increases in the tumor cell loss from the lungs of c57bl/6j and dba/2j mice challenged respectively with intravenous 125iudr labelled b16 or t 1699 mammary carcinoma cells. the results were reproducible with respect to the optimal doses and the magnitudes and shapes of the dose response curves. | 1981 | 6752286 |
| the use of an anaerobic incubator for the isolation of anaerobes from clinical samples. | an anaerobic incubator was compared with a standard jar system for the isolation of anaerobes from clinical material. seventy specimens were selected as likely to yield anaerobes: 342 different anaerobes were isolated in the incubator and 347 in anaebrobic jars. these included bacteroides spp (43%), peptococcus spp (26%), peptostreptococcus spp (13%), veillonella spp (7%), fusobacterium spp (7%), clostridium spp (2%) and miscellaneous gram-positive nonsporing bacilli (2%). differences in isolati ... | 1982 | 6752210 |
| differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor. | sera from mice infected with plasmodium yoelii or plasmodium berghei and given endotoxin contained nonspecific mediators which killed both species of parasite and tumor cells in vitro. the sera resembled tumor necrosis sera obtained from mice given macrophage-activating agents such as propionibacterium acnes (formerly designated corynebacterium acnes) or mycobacterium bovis bcg and then endotoxin. cytotoxicity developed parallel to parasite killing activity and indicated that macrophages were ac ... | 1982 | 6752029 |
| acetic, propionic, and oleic acid as the possible factors influencing the predominant residence of some species of propionibacterium and coagulase-negative staphylococcus on normal human skin. | the minimum inhibitory concentration (mic) of acetic and propionic acid for resident bacteria on normal human skin, such as propionibacterium acnes and staphylococcus epidermidis, was 25 mg/ml or more at any ph tested (ph 5.5-6.8). while the mic of these acids for most of the transient bacteria was markedly decreased by lowering the ph of the media and at ph 5.5, the mean ph value of the normal human skin, the mic was 6.25 mg/ml or less. the mic of oleic acid for some strains of gram-positive tr ... | 1984 | 6744125 |
| comparative bacteriology of chronic blepharitis. | one hundred and fifteen patients with chronic blepharitis were compared with 47 normal controls. six clinically distinct groups of blepharitis were observed: staphylococcal; seborrhoeic, alone, with associated staphylococcal superinfection, meibomian seborrhoea, or secondary inflammation of the meibomian glands; and meibomian keratoconjunctivitis (mkc). staphylococcus aureus was isolated in appreciable frequency from the staphylococcal and the mixed staphylococcal/seborrhoeic groups in contrast ... | 1984 | 6743618 |
| changes in the bacterial flora of the external ear canal from the wearing of occlusive equipment. | external otitis has been associated with wearing obstructive gear covering the earlobe and external ear canal. in this study we investigated the changes in the bacterial flora of the external ear canal after wearing rubber hoods. the bacterial flora of external ear canals surfaces was investigated in a group of 19 volunteers who wore rubber hoods for a period of 25 to 30 minutes while doing manual work. the protective effect of 2% acetic acid was tested by instilling it in the left ear of all pa ... | 1984 | 6738278 |
| photoinactivation of propionibacterium acnes by near-ultraviolet light. | photodestruction of propionibacterium acnes was investigated by broad-band near-ultraviolet light. the inactivation of the bacteria was found to be oxygen dependent, and without o2 practically no photoinactivation occurred. d2o caused an increased inactivation (d10 = 5 kj/m2 in d2o as compared to d10 = 11 kj/m2 in normal water). decreased temperature during illumination increased the ability to form colonies. the results are compared with corresponding results for other types of cells and the de ... | 1984 | 6730638 |
| enhancement of thermal response of normal and malignant tissues by corynebacterium parvum. | further studies were carried out on the combined effects of corynebacterium parvum and hyperthermia on animal tissues and cultured chinese hamster ovary cells. experimental animals were c3hf/sed mice derived from our defined flora mouse colony. tumors were eighth-generation isotransplants of a spontaneous fibrosarcoma, fsa-ii. hyperthermia was given by immersing the mouse foot or culture flasks in the constant temperature water bath. present experiments include thermal enhancement of c. parvum a ... | 1984 | 6722772 |
| effect of pregnancy on augmentation of natural killer cell activity by corynebacterium parvum and toxoplasma gondii. | studies were performed to determine the effect of pregnancy on nk cell activity and the augmentation of nk cell activity which normally follows injection of killed c. parvum or live t. gondii. when compared to cells from virgin mice, peritoneal and splenic cells from unstimulated pregnant mice showed no significant difference in nk activity. in contrast, nk activity of peritoneal cells from pregnant mice that received c. parvum or t. gondii was significantly lower than that found in comparably t ... | 1984 | 6715884 |
| the adverse effect of pregnancy on macrophage activation. | recently a remarkable decrease in the resistance to infection with listeria monocytogenes and toxoplasma gondii in pregnant mice was demonstrated. since activated macrophages are important in the resistance against these organisms, studies were performed to determine whether pregnancy has an adverse effect on the activation of macrophages and effector functions of these macrophages. peritoneal macrophages from normal pregnant and virgin mice or from pregnant and virgin mice previously injected w ... | 1984 | 6713543 |
| immunotherapy with biochemically dissociated fractions of propionibacterium acnes in a murine ovarian cancer model. | the antitumor effect of two strains of propionibacterium acnes (pai and paii) and chemically derived fractions from the whole bacterial cell were studied using a murine ovarian teratocarcinoma (mot) model. when injected i.p. in high doses (700 to 1400 micrograms/mouse), both strains produce survival of a significant proportion of tumor-bearing mice (30 to 90%). on a weight to weight basis, however, pai was significantly more effective than paii. pai and paii were extracted using pyridine, which ... | 1984 | 6713388 |
| variably acid-fast bacteria in a fatal case of hodgkin's disease. | 1984 | 6703743 | |
| the bacterial flora of the forehead and back of alaskan native villagers in summer and in winter. | the bacterial flora of the forehead and back of eskimo and indian villagers in arctic alaska was determined in midsummer and in winter (temperature -29 degrees to -46 degrees c). specimens collected by the wet swab method were transported overnight, chilled, to seattle in buffered diluent with triton x-100. control tests showed good survival of principal skin organisms with moderate or large initial populations and a disproportionately greater loss with an initial sparse population. results of t ... | 1984 | 6699430 |
| difficulties in producing antibodies to purified propionibacterium acnes exocellular enzymes. | attempts were made to produce antisera to purified preparations of propionibacterium acnes lipase, hyaluronate lyase and acid phosphatase in rabbits. antiserum to lipase (neutralizing titre i:32) was produced using conventional methods. lipase (30 micrograms) in freund's complete adjuvant (fca) was injected into multiple sites thrice at weekly intervals. antibody levels were boosted by i.v. injections of 30 micrograms in saline at 2-weekly intervals for 2 months. such regimes failed to raise ant ... | 1984 | 6691919 |
| tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | the physiologically occurring tetrapeptide, tuftsin (thr-lys-pro-arg), was examined for its effects on guinea pig peritoneal macrophages. adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) m, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation product, thromboxane b2 (txb2), was studied. tuftsin causes both albumin-elicited and c. parvum-activated møo to set free superoxide anion (o2) and hydrogen peroxide (h2o2). it also st ... | 1983 | 6687720 |
| non-specific immunization against bovine tropical theileriosis (theileria annulata) using killed corynebacterium parvum. | killed corynebacterium parvum was used as an adjuvant for the production of non-specific resistance against theileria annulata in cattle. groups of cross-bred (bos indicus x bos taurus) calves were administered c. parvum adjuvant subcutaneously and were then challenged with t. annulata-infected ticks on 45, 60 or 90 days later. the challenge caused mild reactions in the protected calves. none of the 10 immunized calves died due to theileriosis, whereas all three paris of susceptible control calv ... | 1983 | 6685397 |
| new therapeutic approaches to treatment of malignant gliomas: chemotherapy and immunotherapy. | 1983 | 6680086 | |
| in vitro activity of u-57930e against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline. | the in vitro activity of u-57930e, a pipecolic acid amide of clindamycin, was compared with those of clindamycin, ampicillin, carbenicillin and tetracycline against 321 anaerobic clinical isolates. the mic (micrograms/ml) of u-57930e that inhibited 95% bacteroides fragilis, peptococcus prevotii, b. melaninogenicus and p. asaccharolyticus was 0.0625; 0.03125 for peptostreptococcus anaerobius, b. vulgatus, propionibacterium and peptococcus species. clindamycin, on the other hand, gave mic values o ... | 1983 | 6678915 |
| effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. | the effect of the immunostimulant c. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. male swiss albino mice were injected intra-venously with m. arthritidis culture and intraperitoneally with c. parvum. it was shown that mice immunostimulated with c. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. however, when the arthritis was established c. parvum had no effect on ... | 1983 | 6678690 |
| changes in anatomical distribution of tumour lesions induced by platelet-active drugs. | to examine the effect of platelet-active drugs on the spread of blood-borne tumour cells, two murine tumours, sarcoma 180 (s-180) and tlx-5 lymphoma, were selected. following intravenous (iv) injection into cba mice the former elicited thrombocytopenia and formed discrete pulmonary tumours, whereas the latter failed to elicit thrombocytopenia and formed discrete tumours in all visceral organs examined except the lungs. s-180 cells were injected iv into mice pre-treated with ra233 (known to preve ... | 1983 | 6677619 |
| [the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum on metastatic tumor proliferation]. | the effects of surgical intervention and removal of the primary tumor, and the effectiveness of corynebacterium parvum (cp) on the proliferation of metastatic tumor tissue were investigated by using autoradiography to follow post-operative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed hypersensitivity reaction and the cytotoxicity (adcc, nk) of lung cells were studied, to investigate the immune capacity of ... | 1983 | 6676630 |
| [current trends in immunotherapy of tumors of the lung]. | 1983 | 6675558 | |
| [etiological investigation of propionibacterium acnes variant isolated from children with kawasaki disease]. | 1983 | 6663741 | |
| effects of oxygen concentration on biomass production, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. | propionibacterium acnes, propionibacterium avidum and propionibacterium granulosum were grown in continuous culture at 0-100% air saturation using a semi-synthetic medium. maximum specific growth rate, biomass concentration and extracellular lipase, hyaluronate lyase and phosphatase activities were determined. all three species were capable of growth at 100% air saturation but at reduced growth rates. the presence of oxygen altered the production of extra-cellular enzymes. propionibacterium avid ... | 1983 | 6663280 |
| [mechanism of the antitumor immunity potentiated by anaerobic corynebacterium parvum]. | 1983 | 6662469 | |
| response of tumors to biologic modifiers and chemotherapeutic agents. | the use of the fanft model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. we studied c. parvum and glucan immunotherapy of fanft tumors, and demonstrated the enhancement of tumor growth following glucan administration. weekly injections of cyclophosphamide (cy) retarded tumor growth and increased survival. combining c. parvum or glucan with cy resulted in greater tumor growth inhibition than cy alone. our data support the concept ... | 1983 | 6658848 |
| acute polyarthritis following the use of corynebacterium parvum vaccine (coparvax) for malignant pleural effusion. | a 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of corynebacterium parvum vaccine for pleurodesis. within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs. | 1983 | 6657546 |
| the influence of endotoxin in vitro on hepatic macrophage lysosomal enzyme release in different rat models of hepatic injury. | since bacterial endotoxin is known to be involved in the pathogenesis of hepatic injury, the influence of endotoxin on lysosomal enzyme production by hepatic macrophages has been investigated. macrophages have been isolated from the livers of normal rats, from the livers of rats given stilboestrol subcutaneously 4 days previously and from the livers of rats given corynebacterium parvum intravenously 6 days previously. following isolation and overnight culture, the macrophages have been maintaine ... | 1983 | 6651924 |
| growth of propionibacterium acnes strains on semisynthetic medium; antigenic polysaccharide production. | a semisynthetic medium, containing yeast extract as the only non defined component and glucose, glycerol, tween 80 and mineral salts, has been developed to grow the strains of propionibacterium acnes beck 2037, gerrath 2038 and vogel 2039, at a rate comparable to that of complex media. an average of 10(12) cells per 1 (equivalent to approximately 1.5 g/l dry weight) was usually achieved. these yields are appropriated for biochemical and immunological studies, e.g. cell wall preparation, polysacc ... | 1983 | 6649955 |
| protection of cattle against theileria annulata infection using corynebacterium parvum. | four groups of calves (a, b, c and d) each consisting of five calves were used for the present study. group a calves were given corynebacterium parvum alone. group b calves were inoculated with inactivated ground-up-tick supernate (guts) prepared from hyalomma anatolicum anatolicum infected with theileria annulata plus c. parvum. group c received only inactivated guts. all the surviving calves of groups a to c were exposed on day 45 post-inoculation to a lethal tick challenge along with suscepti ... | 1983 | 6649060 |
| [corynebacterium acnes osteitis. a case in a child]. | the authors report a case of corynebacterium acnes osteitis in an 11 year old girl, involving the upper of the right tibia. the lesion resembled a malignant tumour radiologically and tuberculosis histologically. scintigraphy revealed involvement of the seventh right rib. 3 months treatment with pristinamycin resulted in cure. | 1983 | 6646947 |
| organ distribution of tritium labeled corynebacterium parvum in mice. | 1983 | 6645221 | |
| coparvax for malignant effusion? | 1983 | 6641514 | |
| treatment of advanced ovarian malignancy with chemoimmunotherapy using autologous tumor and corynebacterium parvum. | fourteen patients with advanced ovarian epithelial carcinoma were treated with a combination of chemotherapy and immunotherapy. the chemotherapy consisted of either melphalan or a combination of adriamycin, cytoxan, and cisplatin. the immunotherapy consisted of the injection of autologous radiation-attenuated tumor and corynebacterium parvum. no significant toxicity occurred as a result of the immunotherapy, and there was no evidence of tumor growth at the sites of injection. the autologous tumo ... | 1983 | 6633998 |
| effects of the removal of the primary tumor and immunotherapy with corynebacterium parvum on metastatic tumor proliferation. | the effects of surgical intervention by removal of the primary focus, and the effectiveness of an immunomodulator, corynebacterium parvum (cp), on the proliferation of metastatic tumor tissue were investigated by following the postoperative changes in the 3h-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. in addition, the delayed type hypersensitivity reaction (dth) was studied to investigate the immune capacity of the host. the labelling rate of mic ... | 1983 | 6624533 |
| [antigenic relationship between the chemically-induced mouse bladder tumor and corynebacterium parvum]. | 1983 | 6620769 |