Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| [t4 carcinoma of the oral cavity responsive to bilateral 5-fu intra-arterial infusion and simultaneous irradiation]. | 5-fu intra-arterial infusion and simultaneous irradiation can cure head and neck cancer without leaving any functional disturbance. catheters were inserted into the bilateral superficial temporal arteries in a case of t4 carcinoma of the oral cavity, and this treatment was performed. the patient was a 54-year-old male with squamous cell carcinoma involving the right tonsil, right and left sides of the soft palate, the uvula, right gingiva, right lingual margin, and right buccal mucous membrane. ... | 1990 | 2389962 |
| [intra-arterial infusion chemotherapy in bladder cancer]. | between 1976 and 1985, 35 patients with bladder cancer were preoperatively treated with intra-arterial doxorubicin (adm) chemotherapy. we separated these patients into 2 groups according to regimen: a) 1-3 shots of adm infusion with or without radiotherapy, and b) 3-day courses of adm infusion with low-dose radiotherapy. the 5-year actual survival rate according to stage (t category) was 100% in t1-2, 37.5% in t3 and 23.3% in t4. in t1-2, bladder preservative operations were done on 50% of the p ... | 1990 | 2389958 |
| correlation between thyroxine, triiodothyronine and thyrotropin in geriatric patients with goitre. | serum tsh, t4 and t3 have been assayed in three groups of older persons (greater than 60 years): in 28 normal subjects (a), in 80 patients with nontoxic goitre (b), in 22 patients with hyperthyroidism (c). group b was divided in group b-1 (tsh 0.20-0.30 mu/l) and group b-2 (tsh greater than 0.30 mu/l). the test characteristics were determined by comparison of group c patients with group a patients and the former with group b patients. the specificity and posterior probability of tsh test calcula ... | 1990 | 2389637 |
| effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the bb/wor rat. | thalidomide, a derivative of glutamic acid, has immunosuppressive effects and suppresses graft-vs-host disease in the rat and following bone marrow transplantation in man. it is effectively used in the treatment of erythema nodosum leprosum and has a potential therapeutic effect in a variety of autoimmune diseases. in view of these observations, we evaluated the effect of thalidomide on the incidence of spontaneous and iodine-induced lymphocytic thyroiditis and spontaneous insulin dependent diab ... | 1990 | 2389627 |
| development of adrenomedullary function in suckling rats: effects of high doses of thyroxine and cortisol. | the development of epinephrine, norephinephrine, and total catecholamine secretion in plasma and andrenal glands was studied in newborn rats at short intervals: at day 2, 4, 6, 8, 10, 12 and 23. the increase in the plasma level of epinephrine represents a maturation of the secretion of the adrenal medulla. the increase in plasma of epinephrine and norepinephrine and the content of catecholamines in the adrenal glands of both normal animals and those treated with either high doses of t4 or cortis ... | 1990 | 2389622 |
| effects of ichthyophonus hoferi on condition indices and blood chemistry of experimentally infected rainbow trout (oncorhynchus mykiss). | body condition, hepatosomatic index and blood chemistry of oncorhynchus mykiss experimentally infected with a tissue dwelling fish pathogenic fungus, ichthyophonus hoferi, were monitored over a 6 wk period. this was to determine whether the infection constituted a stress manifest by changes in the hypothalamic-pituitary interrenal axis, and especially plasma cortisol levels. infection caused anaemia and leucopenia but did not change the condition, hepatosomatic indices, or plasma chloride, chole ... | 1990 | 2388355 |
| expression and function of the uvsw gene of bacteriophage t4. | the uvsw gene of bacteriophage t4 is involved in many aspects of phage dna metabolism, including replication, recombination and repair. to approach the function of uvsw, the structure and expression of the uvsw gene were first explored. molecular analyses defined the promoter region, the transcriptional start site, and the probable initiation codon. the required promoter region contains a sequence resembling the consensus for t4 late promoters. furthermore, transcriptional analyses indicated tha ... | 1990 | 2388264 |
| [a long-term follow-up study of patients with goitrous hashimoto's disease--prognosis and its predictive factors]. | to clarify the clinical course and prognosis in patients with hashimoto's disease, thyroid function was examined in 199 patients (166 females, 33 males) about every six months for an average of 10.5 years in females and 7.5 years in males. the diagnosis of hashimoto's disease was based on the presence of diffuse goiter, positive thyroid autoantibodies (antimicrosomal antibodies greater than or equal to 400 and/or antithyroglobulin antibodies greater than or equal to 100) and/or the typical histo ... | 1990 | 2387426 |
| alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats. | the influence of altered thyroid state is investigated on plasma apolipoprotein-a-i (apo-a-i), apo-b, and apo-e levels and on apo-a-i, apo-a-ii, apo-b, apo-e, hepatic triglyceride lipase (htgl), and low density lipoprotein (ldl) receptor mrna levels in rat liver and intestine. plasma total cholesterol and triglycerides are unchanged in hyperthyroid rats. liver apo-a-i mrna levels increase 3-fold, whereas intestinal apo-a-i mrna levels remain constant. plasma apo-a-i levels almost double after l- ... | 1990 | 2387252 |
| medium 3,5,3'-triiodo-l-thyronine (t3) and t3 generated from l-thyroxine are exchangeable in cultured gc cells. | previous studies in rats have shown that the ratio anterior pituitary nuclear l-triiodothyronine (t3) derived from intracellular deiodination of l-thyroxine [t3(t4)]/plasma t3(t4) is much greater than for exchangeable t3 [t3(t3)]. we have addressed the hypothesis that t3(t4) is either selectively accumulated or selectively retained by nuclei in comparison to exchangeable t3 [t3(t3)] in cultured gc cells. gc cells readily generated t3 from t4. when mean medium t3(t4) was experimentally maintained ... | 1990 | 2387247 |
| 32p-postlabelling of 2-hydroxyethylated, ethylated and methylated adducts of 2'-deoxyguanosine 3'-monophosphate. | ethylene oxide, diethyl sulphate and dimethyl sulphate were used to synthesize the corresponding 7-alkylation products of 2'-deoxyguanosine 3'-monophosphate (dgmp). the purified adducts were used as substrates in the 32p-post-labelling reaction with t4 polynucleotide kinase. the kinetics of phosphorylation were studied with 7-(2-hydroxyethyl)-dgmp: most net product was formed by 15 min and only a small increase was seen until 4 h. when different concentrations of the adducts were tested, a compl ... | 1990 | 2387026 |
| structure calculations for single-stranded dna complexed with the single-stranded dna binding protein gp32 of bacteriophage t4: a remarkable dna structure. | in this study it is established by calculation which regular conformations single-stranded dna and rna can adopt in the complex with the single-stranded dna binding protein gp32 of bacteriophage t4. in order to do so, information from previous experiments about base orientations and the length and diameter of the complexes is used together with knowledge about bond lengths and valence angles between chemical bonds. it turns out that there is only a limited set of similar conformations which are ... | 1990 | 2386789 |
| the maturation-dependent conformational change of the major capsid protein of bacteriophage t4 involves a substantial change in secondary structure. | we have investigated the conformational basis of the expansion transformation that occurs upon maturation of the bacteriophage t4 prohead, by using laser raman spectroscopy to determine the secondary structure of the major capsid protein in both the precursor and the mature states of the surface lattice. this transformation involves major changes in the physical, chemical, and immunological properties of the capsid and is preceded in vivo by processing of its major protein, gp23 (56 kda), to gp2 ... | 1990 | 2386785 |
| thyroid hormone-inducible monoamine oxidase inhibitor in rat liver cytosol. | an endogenous inhibitor of monoamine oxidase (mao) was separated by gel-filtration from 105,000 g supernate of t4-treated rat liver cytosol. the inhibition by this inhibitor was concentration-dependent and more potent for a-form mao than for b-form mao. the mode of inhibition was competitive either with 5-hydroxytryptamine or beta-phenylethylamine. the molecular weight of this inhibitor was estimated to be 600-700 by gel filtration. the pi value was determined to be 3.0 by isoelectric focusing. ... | 1990 | 2386549 |
| responsiveness of l-s ratio of the amniotic fluid to intra-amniotic administration of thyroxine. role of fetal age. | since 1982 we have accelerated fetal maturation with intra-amniotic thyroxine (t4) in more than 140 patients. the purpose of this analysis was to determine the rate of change of the ratio of lecithin to sphingomyelin (l/s) after administration of t4 at different gestational ages, and to compare the responses to the first and the second administration of t4. fifty-nine cases in which administration of t4 was continued for 2 weeks or more, and in which at least 3 determinations of l/s had been per ... | 1990 | 2386014 |
| [investigation of the bacterial flora in the tonsillar lacunae and serum levels of streptococcal antigen-specific antibodies in patients with pustulosis palmaris et plantaris]. | the purpose of this study was to clarify the relationship between bacterial flora in tonsillar lacunae and antistreptococcal antibody in sera of the patients with pustulosis palmaris et plantaris (ppp). since the pustules develops or worsens after tonsillitis in many patients with ppp, a pathogenic role of tonsillar bacteria is suggested, but no significant association has been proven so far. in this study, the aerobes in the tonsillar lacunae were identified and quantitated in 15 adult patients ... | 1990 | 2384834 |
| [clinical study on laryngeal cancer]. | a clinical study was made of 131 patients with laryngeal cancer treated in our department during 13 years from 1975 to 1987. the mean age of patients was 64.8 years, and the male-female ratio was 20.8:1. there were 87 cases of the glottic type, 42 of the supraglottic, and 2 of the subglottic type. cases in the early stages (stage i, ii) predominated in the glottic type, whereas advanced stage tumors (stage iii, iv) were predominant in the supraglottic type (chi 2-test, p less than 0.01). hoarsen ... | 1990 | 2384832 |
| cell-mediated and humoral immunity in leprosy in children. | cell-mediated and humoral immunity were studied in 25 children between 0 and 14 years with leprosy. cell-mediated immunity was studied in vivo by lepromin and epicutaneous sensitization with dinitrochlorobenzene (dncb) and t-lymphocytes and their subpopulations (t4 and t8) in the peripheral blood. humoral immunity was evaluated by b-lymphocyte count and immunoglobulins (igg, igm and iga). along with complement, component c3 was also measured in the serum. lepromin (mitsuda) and dncb responses we ... | 1990 | 2384638 |
| photophysics of tryptophan in bacteriophage t4 lysozymes. | bacteriophage t4 lysozyme contains three tryptophan residues in distinct environments. lysozymes with one or two of these residues replaced by tyrosine are used to characterize the photophysics of tryptophan in these individual sites. the fluorescence spectra, average lifetimes, and quantum yields of these three single-tryptophan variants are understandable in terms of the neighboring residues. the emission spectra and radiative lifetimes are found to be the same for all three species while the ... | 1990 | 2383546 |
| tumour imaging of bladder carcinomas and their metastases with 111indium-labelled monoclonal anti-cea antibody bw 431/26. | fifty-one patients with muscle-infiltrating bladder carcinoma (t2-t4, n0-3, m0-1) were studied with a new imaging technique using murine monoclonal antibody directed against the carcinoembryonic antigen (cea). a total number of 67 investigations were performed. the intact 111indium-labelled antibody (bw 431/26, behringwerke marburg) detected 86% of primary tumours, 93% of local and 75% of distant metastases whether there was an elevated cea level in serum or not. immunohistologically (avidin-bio ... | 1990 | 2383485 |
| exogenous interleukin 2 (il 2) reconstitutes deficient in vitro t-cell growth of patients with chronic lymphocytic leukemia of b-cell lineage (b-cll). | mechanisms of tumor growth are concerned with the possibility that neoplasms are disturbed in their response to growth factors. interleukin 2 (il 2) is secreted by activated t-cells and is required for autocrine t-cell growth. controversy exists as to the functional capacity of t-lymphocytes in patients with b-cell chronic lymphocytic leukemia (cll). we studied 14 patients with previously untreated, early cll. data were compared to 16 healthy individuals. immunophenotyping showed that t-cells in ... | 1990 | 2382990 |
| the preepiglottic space revisited: is it significant? | one hundred fifty-four laryngeal specimens were examined by a serial sectioning method to determine the importance of the preepiglottic space (pes) in the spread of cancer. controversy surrounds the status of the pes in the two major tnm classifications regarding laryngeal anatomy. however, both the uicc (international union against cancer) and the ajccs (american joint commission on cancer staging) imply a t3 grading for tumors invading the pes. several variables relating to laryngeal cancer sp ... | 1990 | 2382783 |
| [characteristics of specific binding of thyroid hormones with plasma membranes of syncytiotrophoblast of human placenta]. | kinetic and equilibrium characteristics of the interaction of triiodothyronine (t3) and its structural analogues with plasmatic membranes of human placental syncytiotrophoblast were studied. the specific binding was temperature-dependent, saturable, reversible, selective and stereospecific. the following values of the binding parameters were obtained: association rate constant--1.0 x 10(10) m-1min-1, dissociation rate constant (fast phase)--2.4 x 10(-1) min-1, half-life time of the complex--2.9 ... | 1990 | 2382428 |
| [the thyroid hormone picture of alcoholics in connection with their liver status]. | this work was performed in order to analyze thyroid hormone picture of alcoholic patients with reference to hepatic damage. forty consecutive patients of male sex, aged 28-64 years, were investigated. they consumed more of 50 g ethanol/day for at least 2 years. according to investigations on hepatic condition, 2 cases had normal liver, 22 cases had steatosis and 16 had cirrhosis. none of patients disclosed a clinical and/or hormonal behaviour pointing to alterations of thyroid function. in alcoh ... | 1990 | 2381553 |
| [the effect of long-term treatment with nadolol on serum levels of thyroid hormones and thyrotropin in patients with hypertension]. | in 20 males with stage ii hypertensive disease, effects of 2-week-, 2-, and 6-month monotherapy with nadolol given in doses 40 to 160 mg daily were examined on the levels of thyroidal hormones (t3 and t4) and thyroid-stimulating hormone. at the all stages of the therapy, the mean values of the examined parameters were significantly unchanged. nadolol was found to cause a decrease in t3 concentrations at its high baseline values (r = -0.57; p less than 0.05) and in doses greater than 40 mg daily. ... | 1990 | 2381124 |
| the effects of selenium depletion and repletion on the metabolism of thyroid hormones in the rat. | rats were fed selenium-deficient (less than 0.005 mg selenium/kg) or selenium-supplemented diets (0.1 mg selenium/kg, as na2seo2) for up to five wks from weaning to assess the effects of developing selenium deficiency on the metabolism of thyroid hormones. within two wks 3:5,3'-triiodothyronine (t3) production from thyroxine (t4) in liver homogenates from selenium-deficient rats was significantly lower compared with the activity in liver homogenates from selenium-supplemented rats. this decrease ... | 1990 | 2380704 |
| tsh secreting pituitary adenoma in children: a case report. | the clinical presentation of tsh-secreting pituitary adenoma in an 11-year-old boy is reported. hyperthyroidism, signs and symptoms of increased intracranial pressure with the elevation of tsh, t3, t4 were the clues for suspecting this disorder. bilateral carotid angiogram was performed which disclosed a suprasellar mass, and pituitary surgery was performed. electron microscopic examination confirmed the diagnosis of tsh secreting pituitary tumor. | 1990 | 2380650 |
| homogeneous latex immunoassay for thyroid hormone testing. determination of thyroxine and triiodothyronine. | we describe here two latex immunoassays for total thyroxine (t4) and total triiodothyronine (t3). these homogeneous 60 min assays are quantified by optically counting the monomeric particles remaining after agglutination. when precision is assessed, both methods display coefficients of variation of 3-7% for within-run assays and 4-10% for between-run assays. the accuracy of the methods, as tested by dilution and spike recovery experiments, was found to be satisfactory. two correlation studies we ... | 1990 | 2380561 |
| changes in adrenal neuropeptides content [peptide 7b2, neuropeptide y (npy) and vasoactive intestinal polypeptide (vip)] induced by pharmacological and hormonal manipulations. | a novel pituitary peptide, designated 7b2, was shown to be present in the adrenal gland. 7b2-like immunoreactivity was mainly localized in the adrenal medulla, similarly to npy and vip. in order to elucidate the neural and humoral regulation of adrenal 7b2, npy and vip content, wister rats were treated with reserpine (res), ranitidine (rant) or chlorpheniramine maleate (cphm) for 7-10 days. the thyroid hormone excess and deficient states were experimentally produced with thyroxine (t4) treatment ... | 1990 | 2380503 |
| thyroxine 5'-deiodinase in human anterior pituitary tumors. | the activity of t4 5'-monodeiodinase (5'd) in the pituitary was measured in 12 patients with pituitary adenoma (3 patients with acromegaly, 2 with prolactinoma, 1 with cushing's disease, 1 with tsh-producing tumor, and 5 with nonfunctioning tumor) and, as a control, in a patient who died of parotid cancer. the pituitaries, obtained at operation or autopsy, were homogenized in 0.1 mol/l potassium phosphate buffer, ph 7.0, and centrifuged at 800 x g. supernatants were incubated with [125i]t4 and 2 ... | 1990 | 2380333 |
| dilantin and salicylate effects on hepatic thyroxine bio-availability and dialyzable thyroxine. | earlier studies have shown that drugs such as dilantin inhibit t4 binding by thyroid hormone binding globulin (tbg) and cause a displacement of t4 from tbg to prealbumin with no change in the albumin-bound t4 fraction. since recent studies have shown albumin-bound t4 is freely transported into liver, the present studies are designed to investigate drug effects on t4 transport in liver. the effect of salicylate and diphenylhydantoin (dilantin) on t4 in human serum were examined both in vitro by u ... | 1990 | 2379917 |
| influence of chronic treatment with iopanoic acid on thyroxine metabolism in the newborn rat. | parameters of the peripheral metabolism of thyroxine (t4) were studied in the early postnatal period. iopanoic acid (iop) was administered to newborn rats that were either euthyroid or rendered hypothyroid in utero by propylthiouracil (ptu) or methimazole (mmi) administration to the mothers during gestation and injected with thyroxine on postnatal days 6 and 7. in euthyroid newborn rats given iop from postnatal day 6, the plasma t4 level increased (+50%) while the plasma 3,3',5'-triiodothyronine ... | 1990 | 2379915 |
| mechanism of 3' splice site selection by the catalytic core of the suny intron of bacteriophage t4: the role of a novel base-pairing interaction in group i introns. | the catalytic core of the suny intron of bacteriophage t4 is separated from its 3' exon by 837 nucleotides, most of which are part of an open reading frame (orf). here, we report that transcripts truncated within the suny orf self-splice in vitro to a variety of sites in the segment immediately 3' of the core. recognition of these proximal splice sites is shown to depend on (1) the presence on the intron side of a terminal g, which must not be part of a secondary structure; and (2) the ability o ... | 1990 | 2379829 |
| the riia gene of bacteriophage t4. ii. regulation of its messenger rna synthesis. | when the rii genes are first introduced into cells which had been previously infected by t4 phage deleted for these genes, the kinetics of synthesis of riia and riib rna are rapid and identical. we show that this rapid synthesis depends on a functional mota gene for riib, but not for riia, rna synthesis. by primer-extension mapping of t4 messenger rna, we find three promoters close to the riia gene. one of them is an early promoter just before the riia.1 gene; it is used under all conditions tes ... | 1990 | 2379818 |
| the riia gene of bacteriophage t4. i. its dna sequence and discovery of a new open reading frame between genes 60 and riia. | we have determined the dna sequence of the riia gene and have discovered a small open reading frame, riia.1, between genes 60 and riia. the predicted molecular weights of these proteins are 82,840 for riia and 8,124 for riia.1. the riia protein has a repeated motif which suggests that the gene has evolved by duplication. it also has a motif which suggests that it belongs to a group of ompr-like proteins that control regulation of gene expression in response to changes in the external environment ... | 1990 | 2379817 |
| [experiences with simultaneous cytostatic and radiotherapy treatment of advanced cancer of the head and neck]. | fifty-seven patients with stage iii and iv (stage-grouping uicc 1987) carcinoma of the head and neck were primarily treated with both chemotherapy and radiotherapy at the same time. radiation therapy was administered in two series in daily fractions of 2 gy up to a total dose of 70 gy. on the first five days of each series a daily dose of 20 mg/m2 body surface cis-diamino-dichloroplatin (ii) (cis-ddp) was given intravenously. in the group of t3-tumors, there were 78% complete remissions and 89% ... | 1990 | 2378657 |
| lower serum thyroxine levels in rats following prenatal exposure to ethanol. | fetal alcohol syndrome (fas) is noted for poor growth, developmental delays, and mental retardation. in animals, prenatal alcohol exposure alters anatomical, physiological, and neurochemical maturation and produces behavioral changes similar to those in children. since thyroid hormones are critical trophic factors for normal somatic and neural maturation, and since fetal thyroid hormones are profoundly affected by acute maternal ethanol administration, we hypothesized that postnatal effects of p ... | 1990 | 2378431 |
| altered immune status in aluminum reduction plant workers. | from 1978 to 1985, b-cell lymphoma occurred in five employees of an aluminum reduction plant (expected = 0.2; poisson distribution). as immunodeficiency is a known risk factor for b-cell lymphoma, we did a pilot study to evaluate immune function in apparently healthy plant workers. twenty-three volunteers were selected for study from 350 workers, representing a range of experience in the potroom and with exposures to strong magnetic fields and volatilized aromatic hydrocarbons. potroom workers h ... | 1990 | 2378372 |
| cloning of pcr products after defined cohesive termini are created with t4 dna polymerase. | 1990 | 2377488 | |
| nucleotide sequence of bacteriophage t4 gene 31 region. | 1990 | 2377483 | |
| the nucleotide sequence of the region of bacteriophage t4 inh(lip)-hoc genes. | 1990 | 2377482 | |
| [evaluation of a new strategy for detecting thyroid dysfunction]. | the results of a diagnostic strategy to evaluate thyroid function were assessed. this strategy consists of tsh measurement as the initial biochemical test, assuming that all individuals with normal tsh concentrations are euthyroid and do not require additional measurements of other hormones. the study was carried out in 576 patients whose serum samples had been referred to the laboratory during 4 consecutive weeks for the evaluation of thyroid function. in all cases tsh and free t4 (ft4) concent ... | 1990 | 2377012 |
| [long-term follow-up study of i-131 therapy for graves' disease--index associated with late-onset hypothyroidism]. | we have studied the follow-up of thyroid function in the patients with late-onset hypothyroidism and euthyroidism after i-131 therapy of hyperthyroidism. thirty three patients who did not need the thyroid treatment until ten years after i-131 therapy were classified as euthyroid group. and eleven patients who needed the thyroid supplement of thyroid hormone for late-onset hypothyroidism were classified as hypothyroid group. patients in both groups who required only a single dose of i-131 for suc ... | 1990 | 2376918 |
| correlated morphological and functional study of isolated rat thyroid follicles in suspension culture. | rat thyroid follicles were isolated by collagenase digestion and cultured in suspension on agarose for 1-12 days with 0-0.1-1 mu/ml thyrotropin (tsh). after a 4 h exposure to na125i they were processed for light and electron microscopy, autoradiography and biochemical analysis. follicular 125i accumulation (a) and organification (pbi) were measured. thyroglobulin (tg) content of follicles and 125i-labelled amino acids in tg were analyzed by high-performance liquid chromatography (hplc). without ... | 1990 | 2376285 |
| interaction of sodium molybdate with the thyroid hormone receptor. | the 3,5,3'-triiodothyronine (t3) binding activity of solubilized nuclear proteins from rat liver was decreased when molybdate (10 mm) was present in the incubation medium in the absence of thiol reagents. the equilibrium affinity constant was reduced by 40%. the rate of degradation of t3-receptor complexes at 37 degrees c remained unchanged, but when the extracts were further reincubated in the presence of beta-mercaptoethanol, molybdate had a protective effect after 5 h incubation at 37 degrees ... | 1990 | 2375853 |
| [cloacogenic cancers of the anal canal: a retrospective study of 17 cases]. | this study involved 17 cloacogenic cancers classified on the morson and jass histological scale and on the tnm clinical classification as t1 (4), t2 (3), t3 (3) and t4 (7) and including 5 n+ cases at the time of diagnosis. treatment combined radiotherapy and surgery and the overall actuarial survival was 45% after 5 years. these results confirm that the response to treatment of cloacogenic cancers is similar to that of epidermoid cancers, notably with regard to the response to radiotherapy, and ... | 1990 | 2375615 |
| [the functional topography of the digestive enzymes in the gastrointestinal tract and in nondigestive organs (liver, kidney) in the ontogeny of rats and the effect of inducing agents]. | activities of the digestive enzymes (lactase, maltase, saccharose, di-, tri- and aminopeptidases, alkaline and acid phosphatase) in the gastrointestinal tract, the kidney and the liver in one-day-old and adult rats as well as in 10-day-old rats after injections of hydrocortisone (h) or thyroxine (t4) were determined. on the basis of the results obtained it is summarized that (1) high levels of the digestive enzyme activities are observed in the nondigestive organs in immature and adult rats; (2) ... | 1990 | 2375204 |
| bacteriophage t4 dna packaging genes 16 and 17. | 1990 | 2374730 | |
| [hormonal and metabolic reactions in the human body during prolonged starvation]. | this paper discusses hormonal and metabolic reactions of healthy volunteers exposed to 14-day starvation. this exposure led to many-fold increase of plasma and urinary epinephrine (e); drastic increase of acth and beta-endorphin (be), morning and integrated concentrations of cortisol and sth, aldosterone, t3, glucagon, camp, cgmp, camp-cgmp, acetyl choline (ac), free fatty acids (ffa), lactate, metanephrine (mn) excretion; decrease of plasma norepinephrine (ne) and unchanged ne excretion; decrea ... | 1990 | 2374373 |
| growth hormone and thyroxine affect lipoprotein metabolism in hypothyroid and hypophysectomized rats. | the aim of this study was to evaluate the effect of thyroxine (t4) and gh replacement therapy on serum lipoproteins in rats with primary and secondary hypothyroidism and to see whether recovery of gh activity was associated with normalization of serum lipoproteins. in both the primary and secondary hypoproteins. in both the primary and secondary hypothyroid rats, total cholesterol (tc) was higher than in normal controls, due to an increase in low-density lipoprotein cholesterol (ldl-c) and to a ... | 1990 | 2373983 |
| screening for congenital hypothyroidism in france. misdiagnosed cases: collaborative study of screening centres in france. | misdiagnosed cases of congenital-hypothyroidism (ch) during the first 9 years of the french screening program were analysed. a total of 50 cases were missed (3% of total diagnosed) which represents a severe failure of the system. failures were caused by technical errors of sample collection or tsh assay (n = 27) or due to normal tsh (n = 22) or t4 (n = 1) concentrations in the newborn blood specimens. we conclude that screening methods should be improved and that physicians should remain alert t ... | 1990 | 2373106 |
| effect of total sleep deprivation on 5'-deiodinase activity of rat brown adipose tissue. | prolonged sleep deprivation of the rat produces a progressive increase in energy expenditure and an eventual decrease in body temperature, which suggests a profound derangement in thermoregulation. because increased thermogenic activity in brown adipose tissue (bat) is a likely mechanism mediating the observed increase in energy expenditure, we focused our attention on the effect of total sleep deprivation on bat type ii 5'-deiodinase (5'd-ii), since its activation indicates bat stimulation and ... | 1990 | 2373059 |
| repair of x-ray-induced single-strand breaks by a cell-free system. | repair of x-ray-induced single-strand breaks of dna was studied in vitro using an exonuclease purified from mouse ascites sarcoma (sr-c3h/he) cells. x-ray-dose-dependent unscheduled dna synthesis was primed by the exonuclease. repair of x-ray-induced single-strand breaks in puc19 plasmid dna was demonstrated by agarose gel electrophoresis after incubating the damaged dna with the exonuclease, dna polymerase (klenow fragment of dna polymerase i or dna polymerase beta purified from sr-c3h/he cells ... | 1990 | 2372879 |
| prognostic factors in locally advanced noninflammatory breast cancer. long-term results following primary chemotherapy. | since 1973 we have treated t3b-t4 (stage iii) breast cancer with various forms of multidisciplinary approaches through prospective trials. the present report analyses the 10-year results of 277 patients. primary chemotherapy consisted of adriamycin plus vincristine given for three or four cycles prior to high-energy irradiation or surgery. in 205 of 277 (74%) additional chemotherapy was planned following the local-regional modality. primary chemotherapy yielded complete plus partial remission in ... | 1990 | 2372569 |
| ontogenic characterization of type i and ii thyroxine 5'-monodeiodinases in brown adipose tissue from fetal and newborn rabbits. | the ontogenic changes in thyroxine 5'-monodeiodinase (5'-md) activity were examined in brown adipose tissue (bat) of fetal (26, 28 and 30 days of gestation) and newborn (1-14 days old) rabbits. a near-maximum stimulation of bat 5'-md activity was reached at 1 mm of dithiothreitol (dtt). the kinetics of 5'-md inhibition by propylthiouracil (ptu) was uncompetitive in fetal and noncompetitive in neonatal tissue. in fetal tissue the ki was 3.2 mm independently of dtt concentration, in newborns from ... | 1990 | 2372564 |
| [total pulmonary atelectasis after epidural anesthesia]. | a case is reported of a 69-year-old man who sustained a total atelectasis of his right lung while undergoing ilio-tibial bypass surgery. this patient had a history of chronic obstructive pulmonary disease. the plain chest film showed a possible right-sided segmental atelectasis as well as pleural thickening on the same side. lung function tests showed up a small obstructive syndrome, with mild hypoxaemia (pao2 60.5 mmhg). the procedure was performed under epidural anaesthesia, carried out with 2 ... | 1990 | 2372158 |
| thyroxine requirement during pregnancy for replacement therapy of hypothyroidism. | we examined the dose requirements of thyroxine (t4) and desiccated thyroid during eight pregnancies of six women who had undergone total thyroidectomy for thyroid carcinoma. in five pregnancies from four patients treated with t4, serum free t4, which was measured by a newly developed radioimmunoassay, decreased during pregnancy but increased above the normal range after delivery. consistent with these changes in free t4, serum tsh (measured by a highly sensitive immunoradiometric assay) increase ... | 1990 | 2371025 |
| autoimmune thyroid disease in the puerperium. predictive value of thyroid enlargement and related hormonal changes occurring during pregnancy. | the incidence of goiter detected during pregnancy and its significance as an indicator of autoimmune thyroid disease after delivery was investigated in a sample of 707 pregnant women (81% in their 2nd trimester of gestation). goiter was detected in 106 subjects (15%). blood t4, t3, tsh, free t4 index (ft4i), antimicrosomal antibodies (ama) and urinary iodine excretion were measured in these women and in a control group of gravidas without goiter. these measurements were repeated at 1 and 3 month ... | 1990 | 2370422 |
| studies on the nature of iodothyronine binding in familial dysalbuminemic hyperthyroxinemia. | the effects of ph and anionic binding inhibitors were used to test the hypothesis that the increased t4 binding affinity of the variant albumin (alb-fdh) of familial dysalbuminemic hyperthyroxinemia (fdh) is due to an electrostatic bond with the ionized phenolic hydroxyl of the iodothyronine. as determined by charcoal adsorption from 2% serum in which binding to t4-binding globulin and transthyretin had been inhibited, increased t4 binding by alb-fdh was ph dependent and proportional to the ioni ... | 1990 | 2370303 |
| is interstitial implantation essential for successful radiotherapeutic treatment of base of tongue carcinoma? | the role of interstitial implantation in the radiotherapeutic treatment of base of tongue carcinoma remains controversial. at the university of florida, essentially all patients with base of tongue cancer have been managed initially by radiation therapy (with or without neck dissection) with operation reserved for radiation therapy failure. eighty-four patients with invasive squamous cell carcinoma of the base of the tongue were treated with continuous-course external-beam irradiation without in ... | 1990 | 2370179 |
| changes in circulating levels of neuroendocrine and thymic hormones during aging in rats: a correlation study. | it is well established that during early life the thymus gland and the neuroendocrine system influence each other's maturation. furthermore, there is a growing body of evidence indicating that the immune and neuroendocrine systems also function as a bidirectional network during adult life. in order to assess possible changes in the thymic-neuroendocrine network during aging, we undertook to measure and correlate the circulating levels of several neuroendocrine and thymic hormones in young (3 mon ... | 1990 | 2369930 |
| the effects of different iodide availabilities on thyroid function during development in japanese quail. | japanese quail (coturnix japonica) were used to study the effects of different egg iodide (i) availabilities on thyroid function during development. low (less than 50 micrograms 1/kg feed in the maternal diet) and high (1200 micrograms 1/kg feed) i availability were compared to control levels (800 micrograms 1/kg feed), a standard supplementation for game bird feed. we measured thyroid gland content of i, triiodothyronine (t3) and thyroxine (t4), plasma concentrations of t3 and t4, hepatic 5' mo ... | 1990 | 2369822 |
| evidence that bovine growth hormone treatment increases the rate of extrathyroidal 5'-monodeiodinase activity in cattle. | this study examined the influence of bovine growth hormone (bgh) on liver and kidney thyroxine-5'-monodeiodinase activity (tma) in growing beef cattle. in a preliminary trial (trial 1), tissue samples were obtained at slaughter from two placebo-injected and two bgh-injected (29.2 iu/day for 14 days before slaughter) hereford heifers (398 kg avg slaughter wt), with one heifer on each treatment fed at either 1.0 or 2.0 times maintenance energy requirement. in a second trial, tissue and plasma samp ... | 1990 | 2369817 |
| [ureteral metastasis of carcinoma of the kidney]. | involvement of the ureter from metastatic renal cell carcinoma is doubtlessly uncommon. five cases of ureteric secondaries are studied herein. all were ipsilateral and synchronous with the appearance of the primary tumor except for one that was diagnosed 5 years following nephrectomy. the most consistent clinical feature was that of hematuria which presented in all cases. urography (ivp) and retrograde ureteropyelography (rup) proved to be fundamental in the morphologic diagnosis of these lesion ... | 1990 | 2369156 |
| indications for thyroxine therapy after surgery for nontoxic benign goitre. | of 287 consecutive patients, surgically treated at our department for benign, nontoxic goitre during a six-year period, 261 could be followed up, on average, 8.0 years postoperatively. unilateral surgical procedures had been used in 199 patients, subtotal thyroidectomy in 62. 29 patients were treated with thyroxine (t4) immediately postoperatively ("recurrence prophylaxis"); in the other patients thyroxine was only given in cases of hypothyroidism (significant increase of s-tsh). 26 patients had ... | 1990 | 2368548 |
| [prognosis and treatment of advanced breast cancer from the surgical viewpoint]. | twenty-four patients with advanced mammary carcinoma (stage t4) were treated between 1983-1986 at the department of surgery of the university of bochum, marienhospital herne 1. the primary surgical treatment was supported in 18 cases by an ablatio modified from patey, the ablatio simplex were performed on 4 patients; while a thoracical-epigastric flap was applied to one patient. because of the high percentage (16.6%) of advanced breast cancer on all our breast cancer patients, we feel obliged to ... | 1990 | 2368524 |
| high prevalence of occult papillary thyroid carcinoma in a surgical series for benign thyroid disease. | in a surgical series of 277 consecutive patients operated on the thyroid for benign diseases, a high prevalence rate (10.5%) of occult papillary carcinoma was found by means of an accurate histologic examination. indications for surgery were euthyroid multinodular goiter in 25 patients, autonomously hyperfunctioning adenoma in 2 and graves' disease in 2 patients. neoplastic foci were unilaterally found in 25 cases but multifocally in 6 and bilaterally in 4 cases: the diameters ranged from 2-10 m ... | 1990 | 2368170 |
| external radiotherapy in the treatment of tonsillar carcinomas. analysis of 183 cases. | a retrospective analysis of 183 consecutive patients with tonsillar carcinoma observed from 1970 through 1984 and treated by external radiotherapy was carried out. the data were analyzed retrospectively to determine the factors affecting prognosis. tumor size (t) and lymph node involvement (n) were found to be predominant prognostic factors. the difference in 5 year survival rate between t2 and t3 tumors was significant, and that between n1 and n3 was highly significant, whereas difference in su ... | 1990 | 2368168 |
| [disorders in the hypophysis-adrenal and hypophysis-thyroid systems of patients with acute pneumonia and the ways for their therapeutic correction]. | using ria, 188 patients with acute pneumonia were examined over time for the blood acth, cortisol, tth, t3 and t4 content as well as for t4/t3, tth/t3 and tth/t4 correlations. under discussion are causes, approaches to the prevention and correction of the hormonal disorders revealed in the pituitary-adrenal system in patients with an unfavourable course of pneumonia. the majority of the patients manifested thyroid hypofunction and tth hypersecretion, which remained unchanged even during the clin ... | 1990 | 2367990 |
| [discriminatory value of bronchoalveolar lavage parameters in differential diagnosis--exogenous allergic alveolitis, sarcoidosis and patients with healthy lungs]. | for this study, the results of 487 bal investigations involving 126 patients with sarcoidosis, 34 patients with exogenous-allergic alveolitis, 18 subjects with healthy lungs, and 309 patients with other pulmonary disorders, were analysed. the diagnoses had been established independently of the bal results. after elimination of interdependent variables, the discriminatory usefulness of the bal parameters: total number of cells, relative percentage of lymphocytes, natural killer cells, and t4/t8 r ... | 1990 | 2367370 |
| [procollagen-iii-peptide in bronchoalveolar lavage fluid as an index of fibrosis in sarcoidosis and idiopathic lung fibrosis?]. | in order to answer the question whether in sarcoidosis and idiopathic pulmonary fibrosis there is a relationship between the activity of alveolitis (t4/t8 ratio in sarcoidosis, number of granulocytes in idiopathic pulmonary fibrosis) and the activity of connective tissue formation (type iii procollagen peptide in the bal fluid) bal was performed in 12 healthy subjects, 33 patients with type ii sarcoidosis, and 26 patients with idiopathic pulmonary fibrosis. in the unconcentrated bal fluid of the ... | 1990 | 2367369 |
| a study of seroprevalence of hiv-1 and hiv-2 in six provinces of people's republic of angola: clues to the spread of hiv infection. | a seroepidemiological study was carried out to determine the distribution of the human immunodeficiency viruses type 1 (hiv-1) and type 2 (hiv-2) in the people's republic of angola, where hiv-2 existence was previously unknown and hiv-1 seropositivity was only reported to be present in luanda and cabinda. a total of 1,695 serum samples were obtained from healthy persons (control group) and from a group of patients in the provinces of zaire (13), lunda-norte (l.n.) (749), luanda (556), huambo (15 ... | 1990 | 2366148 |
| thyroid iodine content and serum thyroglobulin level following external irradiation to the neck for hodgkin's disease. | fifty-four clinically euthyroid patients were evaluated 1 up to 17 yr after external irradiation to the neck for hodgkin's disease. t4 level was decreased in 6%, while basal tsh level was increased in 44%, and tsh response to trh was increased in 66% of the patients with normal basal tsh level. thyroid iodine content (tic), measured in 50 patients, was below 5 mg in 18. the 29 patients with normal basal tsh level had a mean tic (6.8 +/- 2.7 mg) significantly lower (p less than 0.01) than the con ... | 1990 | 2365955 |
| effects of thyroidal, gonadal and adrenal hormones on tissue respiration of streaked frog, rana limnocharis, at low temperature. | in vivo and in vitro effects of thyroidal, gonadal and adrenal hormones were studied on the rate of liver and skeletal muscle respiration in both the sexes of r. limnocharis during active and inactive phases of the annual activity cycle. triiodothyronine (l-t3) and thyroxine (l-t4) did not stimulate tissue (liver and muscle) respiration in any of the experiments irrespective of season, sex and temperature. testosterone, estradiol and corticosterone stimulated o2 uptake significantly irrespective ... | 1990 | 2365405 |
| thyroid hormone binding inhibition in critically ill patients--who is the inhibitor? | in 31 severely ill patients of our intensive care unit an increased thyroid hormone binding inhibition detected by quantitative measurement of the effect of ether extracts of patients' sera on thyroxine tracer binding to tbg was found. as free fatty acids in serum were diminished in these patients, their postulated role as binding inhibitors in the "low t4 syndrome" of critically ill patients must be questioned. it cannot be excluded that thbi assays demonstrating this inhibition measure artefac ... | 1990 | 2365022 |
| anaesthesia, not surgical stress, induces increases in serum concentrations of reverse triiodothyronine and thyroxine during surgery. | effects of anaesthesia on serum concentrations of thyroid hormones during and soon after abdominal surgery were examined in 29 patients undergoing cholecystectomy (n = 22) or removal of gastric cancer (n = 7). they were given one of the following anaesthetics in combination with nitrous oxide in oxygen: epidural bupivacaine, enflurane, pentazocine, ketamine, halothane, epidural bupivacaine and enflurane. regardless of type of anaesthesia, t3 decreased significantly during and after surgery. t4 a ... | 1990 | 2365019 |
| clinical and subclinical colloid goitre in adult camels (camelus dromedarius) at kordofan region of sudan. | colloid goitre was diagnosed in adult camels in the kordofan region of the sudan. the disease is characterized by gross enlargement of the thyroid, histopathological follicular changes, reproductive disorders, low concentrations of circulating thyroid hormones (t3, t4) and normocytic normochromic anaemia. the possible cause of the condition is discussed and iodine supplementation is recommended. | 1990 | 2364252 |
| effect of d-tubocurarine pretreatment on succinylcholine twitch augmentation and neuromuscular blockade. | subparalyzing doses of d-tubocurarine (dtc) given before succinylcholine decrease the duration of neuromuscular blockade. in animal preparations, they also abolish succinylcholine-induced twitch augmentation, defined as a greater-than-maximal contraction in response to a single stimulus. to determine quantitatively the effect of dtc on succinylcholine potency and on twitch augmentation in humans, 60 adult patients, asa physical status i or ii, were assigned randomly to receive either 0.05 mg/kg ... | 1990 | 2363529 |
| cloning and sequencing of bacteriophage t4 genes between map positions 128.3-130.3. | 1990 | 2362813 | |
| [clinical results of conventional fractionation radiotherapy for glottic and supraglottic laryngeal cancers--the usefulness of hyperfractionation for these cancers]. | ninety patients with glottic and eighteen patients with supraglottic laryngeal cancer (anyn, m0) were treated by conventional fractionation radiotherapy between july, 1963 and august, 1988. tumor control and cause specific survival were evaluated according to tumor location (glottic or supraglottic) and tumor size (t1, t2, t3, or t4). as a result, the steepness of dose-response curve for the tumor control in t1-2 glottic and t2 supraglottic tumors was more slanting upwards than that in other lar ... | 1990 | 2362794 |
| [changes in the secondary structure bacteriophage t4 envelope protein after its polymerization]. | circular dichroism (cd) spectra of the structural protein of the bacteriophage t4 sheath (gp 18) in a monomeric native state, helices, polysheaths and contracted sheaths were measured in the range 184-310 nm. the secondary structure of the protein studied was calculated from the spectra in the range 190-240 nm according to provencher and glöckner. it has been shown that the polymerization is proceeded without change of the alpha-helical content in the secondary structure of gp 18: estimated alph ... | 1990 | 2362596 |
| [gene 26 of bacteriophage t4 basal plate. i. two expression products of the cloned gene]. | we have cloned the 1.9 kb ecorv-bglii dna fragment with t4 genes 51, 26, and 25 into the expression plasmid pt7-5 carrying a t7 promoter. the resulting recombinant plasmid, prr5-3, contained t4 genes 26 and 25 in the correct orientation for expression. we expressed these genes using the t7 rna polymerase/promoter system and the synthesis of three polypeptides with the molecular masses of approximately 24, 15, and 8-9 kda was observed. expression of genes from the subcloned dna fragments and from ... | 1990 | 2362588 |
| [anesthetic management of coronary artery bypass graft operation in a patient with hypothyroidism]. | we experienced the anesthetic management of coronary artery bypass graft operation (3 vessels) in a patient with hypothyroidism. prior to the operation, the substitution therapy for thyroid hormone was performed, but thyroid function could not be normalized. from 30 minutes after starting cardiopulmonary bypass, edema appeared on four limbs. also, edema of intestinal tract and the distended abdomen was observed. by administering t4 preparation intravenously edema diminished within about 2 hours ... | 1990 | 2362344 |
| chest wall motion of infants during spinal anesthesia. | to test the extent to which diaphragmatic contraction moves the rib cage in awake supine infants during quiet breathing, we studied chest wall motion in seven prematurely born infants before and during spinal anesthesia for inguinal hernia repair. infants were studied at or around term (postconceptional age 43 +/- 8 wk). spinal anesthesia produced a sensory block at the t2-t4 level, with concomitant motor block at a slightly lower level. this resulted in the loss of most intercostal muscle activ ... | 1990 | 2361911 |
| determination of replacement and suppressive doses of thyroxine. | suppression daily doses of thyroxine (t4) were determined and the daily amounts of t4 required to replace t4 were established in 217 hypothyroid patients. patients with hashimoto's thyroiditis treated daily with 2-3 micrograms/kg lean body mass or 1-2 micrograms/kg body weight t4 had normal serum thyrotrophin (tsh) concentrations, normal response to tsh-releasing hormone (trh) and normal systolic time intervals but doses higher than 3 micrograms/kg lean body mass or 2 micrograms/kg body weight d ... | 1990 | 2361563 |
| lymphocyte subsets in bronchoalveolar lavage fluid and in circulating blood in epidermoid bronchogenic carcinoma. | alveolar macrophages, lymphocyte and granulocyte percentages, together with okt3+, okt4+, okt8+ lymphocyte subsets and okt4+/okt8+ ratio, were evaluated in bronchoalveolar lavage (bal) fluid and in peripheral venous blood (pvb) of neoplastic and nonneoplastic subjects, in order to assess these aspects of immunity in neoplastic disease and to find out if the modifications in the bronchoalveolar environment are correlated to the ones in the circulation blood. bal was performed in 30 patients under ... | 1990 | 2359893 |
| long-term survival of patients with paranasal sinus carcinoma. | the survival rate for all patients with a squamous cell carcinoma of the paranasal sinuses (n = 77) diagnosed in 1960-1985 in a population of approximately 1 million inhabitants was analysed without any selection of cases. this population is geographically restricted to the most northern part of sweden. the 5-year survival rates of patients with t3 and t4 carcinomas were 42 and 14%, respectively (corrected survival), and the 10-year survival rates were 40 and 14%, respectively. in patients with ... | 1990 | 2359595 |
| autogenous translational operator recognized by bacteriophage t4 dna polymerase. | the synthesis of the dna polymerase of bacteriophage t4 is autogenously regulated. this protein (gp43), the product of gene 43, binds to a segment of its mrna that overlaps its ribosome binding site, and thereby blocks translation. we have determined the kd of the gp43-operator interaction to be 1.0 x 10(-9) m. the minimum operator sequence to which gp43 binds consists of 36 nucleotides that include a hairpin (containing a 5 base-pair helix and an 8 nucleotide loop) and a single-stranded segment ... | 1990 | 2359122 |
| altered thyroid hormone metabolism in advanced heart failure. | to determine the prevalence and significance of abnormal thyroid hormone metabolism in congestive heart failure, free thyroxine (t4) index, free triiodothyronine (t3) index, reverse t3 and thyrotropin levels were obtained in 84 hospitalized patients with chronic advanced heart failure. free t4 index was normal in all patients. free t3 index was reduced or reverse t3 elevated, or both, leading to a low free t3 index/reverse t3 ratio in 49 (58%) of the 84 patients. a low free t3 index/reverse t3 r ... | 1990 | 2358611 |
| purification and characterization of hela endonuclease r. a g-specific mammalian endonuclease. | we previously reported a double-stranded endonuclease from hela cells, endonuclease r (endo r), which specifically cleaves duplex dna at sites rich in g.c base pairs. in this report we describe the purification of endo r to near homogeneity by conventional and affinity chromatography. the molecular mass of the active form of endo r is approximately 115-125 kda. sds-gel electrophoresis reveals a major protein species of 100 kda. the enzyme requires mg2+ as a cofactor and is equally active on clos ... | 1990 | 2358441 |
| carcinoma of the supraglottic larynx: a basis for comparing the results of radiotherapy and surgery. | an analysis of 129 patients with 131 squamous cell carcinomas of the supraglottic larynx treated between october 1964 and april 1987 with radiotherapy alone or radiotherapy followed by neck dissection is presented. all patients had a minimum 2-year follow-up. patients were excluded from analysis of disease control at the primary site and/or neck if they died within 2 years of treatment with the site(s) continuously disease-free. local control rates with radiotherapy and ultimate local control ra ... | 1990 | 2358330 |
| changes in tsh-immunoreactivity in the pars tuberalis and pars distalis of the fetal rat hypophysis following maternal administration of propylthiouracil and thyroxine. | the pars tuberalis (pt) of the adenohypophysis is unique in its close spatial relationship to the neurohemal contact area of the median eminence. the morphology of pt-specific secretory cells does not resemble cell types of the pars distalis (pd); the functional role of these cells within the endocrine system is still unknown. one group of young mature female wistar rats received propylthiouracil (ptu), a second group thyroxine (t4) (10 mg/l each in drinking water) from about 3 weeks prior to th ... | 1990 | 2357726 |
| structural studies of immunomodulators. part 2: crystal structure and conformation of azimexon (bm 12.531) an immunostimulant and an anti-tumor drug. | azimexon [2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane] is a derivative of 2-cyanaziridine. azimexon is an immunostimulant which shows therapeutic effects in tumor models and experimental infections in mice in vitro, enhances t lymphocyte transformation in vitro and increases phagocytosis of latex particles by mouse peritoneal cells. in cancer patients it increases blood active t rosettes, increases t4/t8 ratio and is used in the treatment of melanomas. the crystal structure analysis of azi ... | 1990 | 2357266 |
| increasing age impairs the thyroid hormone response to overfeeding. | aging in both man and rodent is associated with increases in body weight and body fat. in young adult rats, mixed calorie overfeeding increases triiodothyronine production and decreases weight gain efficiency compared with chow diets. this study was undertaken to determine whether 4- and 14-month-old adult rats have similar responses in thyroxine (t4) and triiodothyronine (t3) metabolism during mixed calorie overfeeding. four- and 14-month-old male sprague-dawley rats were each separated into tw ... | 1990 | 2356189 |
| dna synthesis is unaffected but subsequent cell division is delayed in tadpole hindlimb epidermis when thyroxine is given in the dark. | in rana pipiens tadpoles, thyroxine (t4) injection in the early light promotes faster hindlimb growth and development than injection early in the dark. t4 also stimulates a significant increase in cell proliferation in the basal epidermal cells of the limb. using autoradiography, we studied the timing of the t4-induced rise in the labeling and mitotic indices on 12l:12d cycles with 0.2 micrograms t4 injection early in the light or dark and on a 12l:3d:1l:8d cycle with a light pulse early in the ... | 1990 | 2354782 |
| temperature, thyroxine, and induced metamorphosis in tadpoles of a primitive frog, ascaphus truei. | to understand the environmental factors and endocrine mechanisms which regulate the extended period (2 to 4 years) of larval development in ascaphus, the effect of temperature and thyroxine (t4 by immersion) on metamorphic changes of the tail, limb buds, operculum, anal fold, oral disc, and teeth were studied in premetamorphic and prometamorphic tadpoles. (1) control tadpoles did not undergo metamorphic change at any of the temperatures tested. (2) when tadpoles were kept in thyroxine solutions ... | 1990 | 2354776 |
| influence of ration level and salinity on circulating thyroid hormones in juvenile atlantic salmon (salmo salar). | following acute exposure to seawater (30 ppt), plasma thyroxine (t4) of atlantic salmon (salmo salar) smolts increased 80% in the first 6 hr, declined to initial levels after 24 hr, and remained stable for 18 days thereafter. in nonsmolts, plasma t4 did not rise immediately after exposure to seawater, fell slightly after 2 days, and remained low for 18 days. plasma triiodothyronine (t3) of smolts and nonsmolts was not affected by acute exposure to seawater. to examine the effect of long-term ada ... | 1990 | 2354765 |
| evidence for the role of thyroxine as a hormone in the physiology of a lizard. | in vivo effects of thyroxine (t4) and triiodothyronine (t3) were studied in male lizards. t4 or t3 (0.5 to 2 nmol) was administered per day over 10 days to surgically thyroidectomized male lizards (35 +/- 2.0 g) and the responses were measured in terms of scale shedding, whole body oxygen consumption (oc), and testicular weight. t3 was more effective in stimulating oc as compared to t4. t4 accelerated scale shedding to a greater extent as compared to t3. t4 was more effective than t3 in restorin ... | 1990 | 2354761 |
| growth hormone stimulates hepatic thyroxine 5'-monodeiodinase activity and 3,5,3'-triiodothyronine levels in rainbow trout (salmo gairdneri). | intraperitoneal injection of rainbow trout (salmo gairdneri) with 0.4 microgram/g of human growth hormone (hgh) increased plasma levels of 3,5,3'-triiodo-l-thyronine (t3) and vmax of the hepatic microsomal 5'-monodeiodinase enzyme (5'd) that converts thyroxine (t4) to t3, with no effect on km or plasma t4 levels. a dose of 0.4 microgram hgh/g increased both plasma t3 and vmax as early as 8 hr postinjection (pi). maximal levels for both parameters occurred at 24 hr pi and significant stimulation ... | 1990 | 2354760 |
| survey of iodine deficiency in a rural area near tehran: association of food intake and endemic goitre. | goitre is endemic in many parts of iran. this study was undertaken first to obtain the base line data and identify the nature of the problem and then to take measures to ameliorate it. shahryar, an endemic area near the capital city, was selected as the pilot field. the sample size was 368 families. sixty-six per cent of females and 54 per cent of males were goitrous. a food consumption survey revealed that 38 per cent and 62 per cent of the families had failed to receive at least 80 per cent of ... | 1990 | 2354688 |