Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| high mobility group box 1 (hmgb1) is upregulated by the epstein-barr virus infection and promotes the proliferation of human nasopharyngeal carcinoma cells. | the current study confirmed the significant high mobility group box 1 (hmgb1) was promoted in human nasopharyngeal carcinoma (npc) tissues by epstein-barr virus (ebv) infection, in association with the malignant status of npc, and promoted the proliferation npc cells rage-dependently. | 2016 | 26382001 |
| acute hepatitis induced by a chinese herbal product qibao meiran wan: a case study. | qibao meiran wan is a chinese herbal product sold as a therapy for tonifying the liver and kidney, dizziness, premature graying of hair, backache, constipation, and night sweats. it is widely available in chinese pharmacies and drugstores and is sold without prescription. we describe a case of acute liver injury in a 26-year-old chinese man who developed symptomatic hepatitis 1 month after starting qibao meiran wan. there was no evidence of viral hepatitis, epstein-barr virus, cytomegalovirus, a ... | 2015 | 26379995 |
| noncoding genomics in gastric cancer and the gastric precancerous cascade: pathogenesis and biomarkers. | gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. it is a multifactorial disease, and its development depends on infection by helicobacter pylori (h. pylori) and epstein-barr virus (ebv), host genetic factors, and environmental factors. the heterogeneity of the disease has begun to be unraveled by a comprehensive mutational evaluation of primary tumors. the low-abundance of mutations ... | 2015 | 26379360 |
| neurological presentation of hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is an inflammatory disorder arising from defects in critical regulatory pathways responsible for termination of inflammatory response. we are presenting a case report of a 20-year-old male, admitted to the department of neurology because of left lower limb weakness and balance disturbances. after a few days of hospitalization, fever occurred. laboratory tests revealed anemia, neutropenia, lymphopenia, and thrombocytopenia. the clinical course and laborato ... | 2015 | 26377985 |
| prevalence and risk factors of gammaherpesvirus infection in domestic cats in central europe. | gammaherpesviruses (ghvs) are a large group of dsdna viruses that can infect humans and several animal species. the two human ghvs, epstein-barr virus and kaposi's sarcoma-associated herpesvirus are known for their oncogenic properties in individuals with immunodeficiency. recently, the first feline ghv, felis catus gammaherpesvirus 1 (fcaghv1) was discovered and frequently found in domestic cats in australia, singapore and the usa. fcaghv1 is more likely to be detected in cats co-infected with ... | 2015 | 26377918 |
| reduced transplacental transfer of a subset of epstein-barr virus-specific antibodies to neonates of mothers infected with plasmodium falciparum malaria during pregnancy. | over 35% of children in a region of malaria endemicity are infected with epstein-barr virus (ebv) by 6 months of age. this susceptibility may be linked to impaired transplacental transfer of antibodies. in this study, we determined the effect of malaria exposure during pregnancy on the transfer of ebv-specific maternal antibodies in a region of western kenya that experiences endemic malaria. pregnant mothers were recruited and followed up until delivery to determine levels of neonatal malaria ex ... | 2015 | 26376931 |
| acute viral hepatitis presenting as cytomegalovirus, hepatitis e and epstein-barr virus igm antibody positive. | we report a case of acute cytomegalovirus (cmv) infection with positive hev and epstein-barr virus (ebv) serology. no patients have been reported positive for immunoglobulin (ig)m antibodies to all three viruses. this patient had progressively increasing titres of igm antibody for cmv, hev and ebv. only cmv dna was detectable before antiviral treatment. after antiviral treatment, the patient recovered completely. at day 180 the cmv igg test had converted to positive with cmv igm (+), ebv igm (-) ... | 2016 | 26376744 |
| rare presentation of orbital plasmablastic lymphoma with oral cavity involvement in an hiv-negative patient. | plasmablastic lymphoma is described as a subtype of non-hodgkin's lymphoma under the category of diffuse large b-cell lymphoma. it is classified by who as hiv-associated lymphoma of the oral cavity. several cases have been reported in non-hiv patients with extra-oral involvement. the characteristic immunohistochemical markers are generally positive for cd138, cd38 and mum1/irf4, and negative or weakly positive for pan b-cell markerscd20, cd79a, pax-5 and bcl-6. we report a rare case of orbital p ... | 2015 | 26376702 |
| epstein-barr virus microrna expression increases aggressiveness of solid malignancies. | the cancer genome atlas (tcga) microrna (mirna) initiative has revealed a pivotal role for mirnas in cancer. utilizing the tcga raw data, we performed the first mapping of viral mirna sequences within cancer and adjacent normal tissues. results were integrated with tcga rna-seq to link the expression of viral mirnas to the phenotype. using clinical data and viral mirna mapping results we also performed outcome analysis. three lines of evidence lend credence to an active role of viral mirnas in s ... | 2015 | 26375401 |
| intracranial involvement of posttransplant lymphoproliferative disorder multiple myeloma. | we report a 61-year-old man with intracranial multiple myeloma (mm) presenting as a posttransplant lymphoproliferative disorder (ptld) following a kidney transplant. two months after his transplant, the man developed acute rejection with epstein-barr virus (ebv) viremia, requiring aggressive immunosuppression. twenty months following transplantation, the patient presented with multiple neurologic deficits. imaging revealed numerous lytic lesions in the skull, most conspicuously a 4.1cm right fro ... | 2015 | 26375326 |
| immune control of oncogenic γ-herpesviruses. | human γ-herpesviruses contain epstein barr virus (ebv), the first human tumor virus that was identified in man, and kaposi sarcoma associated herpesvirus (kshv), one of the most recently identified human oncogenic pathogens. both of these have co-evolved with humans to cause tumors only in a minority of infected individuals, despite their exquisite ability to establish persistent infections. in this review we will summarize the fine-tuned balance between immune responses, immune escape and cellu ... | 2015 | 26372881 |
| pathogenesis of gastric cancer. | gastric cancer (gc) is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. gc is a heterogeneous disease and the endpoint of a long multistep process largely influenced by helicobacter pylori infection, genetic susceptibility, and environmental factors. in a subset of gc cases, infection with the epstein-barr virus (ebv) may also be involved. the development of gc is the consequence of the accumulation of multiple epi/genetic changes during the patient ... | 2015 | 26372822 |
| bendamustine reactivates latent epstein-barr virus. | 2016 | 26371746 | |
| clinicopathologic characteristics of microsatellite instable gastric carcinomas revisited: urgent need for standardization. | microsatellite instable gastric cancer (msi-gc) is a specific molecular subtype of gc. we studied the phenotypes, genotypes, and clinicopathologic characteristics of msi-gc in a white gc cohort and compared our findings with an extended literature review. the study cohort consisted of 482 patients. specimens were available from 452 cases and were used for immunostaining (mlh1, pms2, msh2, msh6) and molecular biological analyses (bat-25, bat-26, nr-21, nr-24, nr-27; epstein-barr virus in situ hyb ... | 2017 | 26371427 |
| cd5 positivity is an independent adverse prognostic factor in elderly patients with diffuse large b cell lymphoma. | diffuse large b cell lymphoma (dlbcl) is the most common non-hodgkin lymphoma. age over 60 years is one of the five parameters of the international prognostic index (ipi), which is the most important clinical prognostic predictor in dlbcl. a previous study on german dlbcl patients over 60 years of age showed that immunoblastic morphology, but not germinal center b cell-like (gcb)/non-gcb subtype, correlated with short survival. we collected 174 dlbcl cases over 60 years of age in taiwan and perf ... | 2015 | 26369546 |
| clinicopathologic features of hydroa vacciniforme-like lymphoma: a series of 9 patients. | hydroa vacciniforme-like lymphoma is a recently recognized cutaneous t-cell lymphoma associated with epstein-barr virus. the disease is observed in children of latin american or asian ethnicity. the authors report the clinical, histopathological, and immunophenotypical features of 9 new mexican patients (m:f = 2:1; mean age, 14.5 years; median age, 13.3 years; age range, 4-27 years), expanding on previous observations of this elusive disease. the most common clinical aspects were persistent faci ... | 2016 | 26368647 |
| ebv and vitamin d status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature. | multiple sclerosis, a debilitating autoimmune and inflammatory disease of the central nervous system, is associated with both infectious and non-infectious factors. we investigated the role of ebv infection, vitamin d level, and cytokine signature in ms patients. molecular and serological assays were used to investigate immune biomarkers, vitamin d level, and ebv status in 83 patients with relapsing-remitting multiple sclerosis and 62 healthy controls. in total, 98.8 % of ms patients showed a hi ... | 2016 | 26365612 |
| treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases. | widespread use of immunosuppressive drugs, both conventional disease-modifying antirheumatic drugs (cdmards) and biologic disease-modifying antirheumatic drugs (bdmards), in autoimmune rheumatic diseases (ards) has been found to be associated with the reactivation of underlying latent viruses. the clinical features of virus reactivation can sometimes mimic flare of the underlying ards. the correct diagnosis and management of such reactivation is crucial, as increasing the dose of immunosuppressi ... | 2015 | 26362747 |
| [oral hairy leukoplakia induced by topical steroids]. | oral hairy leukoplakia (ohl) is an ebv-associated condition of the oral mucosa, which is often painless. it is found predominantly in hiv-positive patients and is considered a clinical indicator of immunosuppression. ohl has rarely been described in hiv-negative patients, being found most often in association with iatrogenic immunosuppression. ohl induced by topical steroids remains extremely rare. | 2015 | 26362131 |
| serological evidence that activation of ubiquitous human herpesvirus-6 (hhv-6) plays a role in chronic idiopathic/spontaneous urticaria (ciu). | acute infection with viral pathogens in the herpesviridae family can trigger acute urticaria, and reactivation of herpesviridae is associated with cutaneous urticarial-like syndromes such as drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (dress). reactivation of latent herpesviridae has not been studied systematically in chronic idiopathic/spontaneous urticaria (ciu). this review proposes that ciu is an inflammatory disorder with autoimmune features ... | 2016 | 26361716 |
| early post-transplant lymphoproliferative disease in the donor ureter without systemic involvement: a case report. | post-transplant lymphoproliferative disease is a serious complication of renal transplantation. major risk factors include epstein-barr virus (ebv) seronegativity and induction immunosuppression with lymphocyte-depleting agents. | 2015 | 26361705 |
| post-transplant lymphoproliferative disorders: a rare case of primary pericardial involvement epstein-barr virus-correlated in heart transplantation. | post-transplant lymphoproliferative disorders (ptlds) are considered a fatal consequence of immunosuppression. we report a case of a 52-year-old patient, who underwent a cardiac transplantation and presented undefined recurrent episodes of pleuropericardial effusions without lymphoadenomegaly at chest radiographs and computed tomography. histopathological analysis of the bioptic pericardium showed a specific chronic inflammation. monitoring endomyocardial biopsies (embs) showed only 1 episodes o ... | 2015 | 26361701 |
| pd-l1 is remarkably over-expressed in ebv-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival. | programmed cell death-ligand 1 (pd-l1) and driver mutations are commonly seen in non-small-cell lung cancer (nsclc). however, the prevelance of pd-l1 over-expression and its prognostic value in epstein-barr virus (ebv) associated pulmonary lymphoepithelioma-like carcinoma (lelc) remains poorly understood. | 2015 | 26361045 |
| pd-1 blockade can restore functions of t-cells in epstein-barr virus-positive diffuse large b-cell lymphoma in vitro. | epstein-barr virus-positive diffuse large b-cell lymphoma (ebv+dlbcl) is an aggressive malignancy that is largely resistant to current therapeutic regimens, and is an attractive target for immune-based therapies. anti-programmed death-1 (pd-1) antibodies showed encouraging anti-tumor effects in both preclinical models and advanced solid and hematological malignancies, but its efficacy against ebv+dlbcl is unknown. herein, we performed experiments using co-culture system with t cells and lymphoma ... | 2015 | 26361042 |
| dasatinib-related follicular hyperplasia: an underrecognized entity with characteristic morphology. | dasatinib, a second-generation tyrosine kinase inhibitor with activity against bcr-abl1 and other src family tyrosine kinases, is approved as a first-line treatment option for philadelphia chromosome-positive chronic myelogenous leukemia (cml) in the chronic phase. recently, lymphadenopathy with morphologic features of reactive follicular hyperplasia was described in a cohort of patients with cml on long-term dasatinib therapy. however, the complete morphologic and immunophenotypic features of t ... | 2015 | 26360368 |
| thrombosis associated with viral hepatitis. | viral hepatitis may promote the development of venous thromboembolism (vte) and, more specifically, portal vein thrombosis (pvt). in this narrative review, we summarize the clinical data and discuss the possible pathogenetic roles of cytomegalovirus (cmv), epstein-barr virus (ebv), and hepatitis a, b, and c viruses (hav, hbv, hcv) in the occurrence of vte. cmv is the first qualified candidate to enter the list of vte minor risk factors, and in the rare case of fulminant infection, both ebv and c ... | 2014 | 26357629 |
| latent virus infection upregulates cd40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis. | epstein-barr virus (ebv) has been identified as a putative environmental trigger of multiple sclerosis (ms) by multiple groups working worldwide. previously, we reported that when experimental autoimmune encephalomyelitis (eae) was induced in mice latently infected with murine γ-herpesvirus 68 (γhv-68), the murine homolog to ebv, a disease more reminiscent of ms developed. specifically, ms-like lesions developed in the brain that included equal numbers of ifn-γ producing cd4(+) and cd8(+) t cell ... | 2015 | 26356194 |
| stromal immune infiltration in hiv-related diffuse large b-cell lymphoma is associated with hiv disease history and patient survival. | understanding tumor microenvironment and its impact on prognosis of hiv-related lymphomas may provide insight into novel therapeutic strategies. | 2015 | 26355571 |
| colon adenocarcinoma with dome-like phenotype: characteristic endoscopic ultrasonography (eus) findings. | an 80-year-old man underwent colonoscopy for proctorrhagia. conventional white-light imaging showed a superficially flat and elevated lesion that appeared to be a submucosal tumor of the sigmoid colon. chromoendoscopy with indigo carmine showed that the margin of the tumor was covered with normal epithelium but that there was a slight depression on its surface. magnification endoscopy with crystal violet staining revealed the amorphous surface structure of the depressed lesion, but the surroundi ... | 2015 | 26355327 |
| composite epstein-barr virus-associated b-cell lymphoproliferative disorder and tubular adenoma in a rectal polyp. | composite tumors are formed when there is intermingling between two components of separate tumors seen histologically. cases demonstrating composite tubular adenoma with other types of tumors in the colon are rare. composite tubular adenomas with nonlymphoid tumors including carcinoids, microcarcinoids, and small cell undifferentiated carcinoma have been reported in the literature. the occurrence of composite lymphoma and tubular adenoma within the colorectal tract is extremely rare. only three ... | 2016 | 26353852 |
| prognostic significance of epstein-barr virus dna detection in pretreatment serum in diffuse large b-cell lymphoma. | it is still a matter of debate whether detection of epstein-barr virus (ebv) dna in pretreatment serum has clinical implications for diffuse large b-cell lymphoma. for this study, we measured ebv dna load in pretreatment serum from 127 diffuse large b-cell lymphoma patients without any underlying immunodeficiency to evaluate its effects on clinical manifestations and prognosis. anthracycline-based chemotherapy in combination with rituximab was given as initial therapy for 119 patients (94%). eps ... | 2015 | 26353084 |
| rare circulating cells in familial waldenström macroglobulinemia displaying the myd88 l265p mutation are enriched by epstein-barr virus immortalization. | the myd88 l265p is a recurrent somatic mutation in neoplastic cells from patients with waldenström macroglobulinemia (wm). we identified the myd88 l265p mutation in three individuals from unrelated families, but its presence did not explain the disease segregation within these wm pedigrees. we observed the mutation in these three individuals at high allele fractions in dna extracted from ebv-immortalized lymphoblastoid cell lines established from peripheral blood (lcl), but at much lower allele ... | 2015 | 26352266 |
| recurrent systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma presenting as a breast implant-associated lesion. | a woman aged 48 years presented with fevers, chills, weight loss, and night sweats. she had significant lymphadenopathy of the left neck as well as the left axilla. her history was significant for bilateral breast augmentation with textured silicone implants more than 25 years ago. excisional biopsy of a cervical lymph node revealed large, atypical cells positive for cd4 and cd30 and negative for epstein-barr virus-encoded ribonucleic acid, cd2, cd3, cd5, cd7, cd8, cd15, cd20, pan-keratin, s100, ... | 2015 | 26351895 |
| drug-induced hypersensitivity syndrome followed by subacute thyroiditis. | drug-induced hypersensitivity syndrome (dihs) is a severe multiorgan system adverse drug reaction with reactivation of human herpesviruses (hhvs) such as hhv-6, hhv-7, cytomegalovirus (cmv) and epstein-barr virus. various complications, including autoimmune diseases, sometimes appear during the course of dihs. we report a case of salazosulfapyridine-induced dihs associated with hhv-6 reactivation. two and a half months after the onset of dihs, subacute thyroiditis occurred, possibly associated w ... | 2017 | 26351424 |
| management of nasopharyngeal carcinoma: current practice and future perspective. | nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern china, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngea ... | 2015 | 26351355 |
| nasopharyngeal cancer: molecular landscape. | nasopharyngeal carcinoma (npc) is a unique epithelial malignancy arising from the superior aspect of the pharyngeal mucosal space, associated with latent epstein-barr virus infection in most cases. the capacity to characterize cancer genomes in unprecedented detail is now providing insights into the genesis and molecular underpinnings of this disease. herein, we provide an overview of the molecular aberrations that likely drive nasopharyngeal tumor development and progression. the contributions ... | 2015 | 26351340 |
| lymphoblastoid cell lines reveal associations of adult dna methylation with childhood and current adversity that are distinct from whole blood associations. | some cohort studies bank lymphoblastoid cell lines (lcls) as a renewable source of participant dna. however, although lcl dna has proved valuable for genetic studies, its utility in epigenetic epidemiology research is unknown. | 2015 | 26351305 |
| a therapeutic trial of valganciclovir in patients with uveitis and positive epstein-barr virus early antigen d igg titers. | to evaluate the effectiveness of a therapeutic trial of valganciclovir in patients with uveitis with positive epstein-barr virus early antigen d immunoglobulin g titers (ebv ea-d). | 2016 | 26350994 |
| dna methylation patterns in ebv-positive and ebv-negative hodgkin lymphomas. | hodgkin lymphoma (hl) is characterized by the presence of hodgkin and reed-sternberg cells. epstein-barr virus (ebv) infection is thought to play an important role in the development of hl. although epigenetic alterations, such as aberrant dna methylation, are known to contribute to the pathogenesis of various malignancies, little is known about such alterations in hl and their putative relationships with ebv infection. | 2015 | 26350502 |
| addition of varicella zoster virus-specific t cells to cytomegalovirus, epstein-barr virus and adenovirus tri-specific t cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. | virus-specific t-cell immunotherapy is emerging as a promising management strategy for virus infections in patients after hematopoietic stem cell transplant (hsct). here we present outcomes of 10 adult patients who received multi-virus-specific t cells prophylactically after hsct. | 2015 | 26349000 |
| autoimmune and atopic disorders and risk of classical hodgkin lymphoma. | results from previous investigations have shown associations between the risk of hodgkin lymphoma (hl) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of hl or only to specific subtypes. we investigated immune diseases and the risk of classical hl in a population-based case-control study that included 585 patients and 3,187 controls recruited from october 1999 through august 2002. we collected information on immune diseases th ... | 2015 | 26346543 |
| ebv-associated cancer and autoimmunity: searching for therapies. | epstein-barr virus (ebv) infects b-, t-, and nk cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. hence, effective immunotherapeutic approaches to eradicate ebv infection might overthrow cancer and autoimmunity incidence. however, currently no effective anti-ebv immunotherapy is available. here we use the concept that protein immunogenicity i ... | 2015 | 26344947 |
| yield of diagnostic tests in obese children with an elevated alanine aminotransferase. | nonalcoholic fatty liver disease (nafld) is associated with obesity and affects roughly 10% of children. however, nafld is often diagnosed by exclusion - that is, obese children with an elevated alanine aminotransferase (alt) are screened for other liver diseases in the absence of a biopsy. this testing is nonstandardized, and professional society recommendations differ. this study examines the yield of testing for disorders other than nafld in this patient population. | 2015 | 26341254 |
| epstein-barr virus associated t-cell lymphoproliferative disease misdiagnosed as ulcerative colitis: a case report. | epstein-barr virus (ebv)-associated t-cell lymphoproliferative disease (lpd) is not uncommon in china, but gastrointestinal involvement is very rare. we report on an immunocompetent patient with ebv-associated t-cell lpd of the colon. the 26-year-old man was initially misdiagnosed with ulcerative colitis (uc). a colon biopsy revealed the presence of small to medium-sized lymphoid cells infiltrating the intestinal wall. the neoplastic cells expressed cd3, cd5, and granzyme b, not cd56. ebv-encode ... | 2015 | 26339440 |
| squash smear cytology of langerhans cell histiocytosis. | squash smear cytology of langerhans cell histiocytosis (lch) has rarely been reported. we described squash cytological findings of cranial lch. additionally, based on recent data that suggests an association of lch with either viral infection or genetic alteration, we investigated the presence of several viruses or mutation of tp53 and braf in lch tissue samples. intraoperative squash smears of a small tissue fragment excised from the lesion demonstrated a mixed population of eosinophils, neutro ... | 2015 | 26339366 |
| development of ebv-encoded small rna targeted pcr to classify ebv positive diffuse large b-cell lymphoma (dlbcl) of the elderly. | epstein-barr virus (ebv)-positive diffuse large b-cell lymphoma (dlbcl) of the elderly has been included in the 2008 who classification of lymphoma as a new provisional entity. ebv-positive dlbcl of the elderly is newly classified due to the main occurrence usually in patients of older than 50-year-old. this study was performed in 91 dlbcl patients from january 2002 to december 2012 in catholic university of st. vincent hospital. age distribution of the patients was 14~87-year-old. specimens wer ... | 2015 | 26339350 |
| stat3 regulates lytic activation of kaposi's sarcoma-associated herpesvirus. | lytic activation of kaposi's sarcoma-associated herpesvirus (kshv) from latency is a critical contributor to pathogenesis and progression of kshv-mediated disease. development of targeted treatment strategies and improvement of lytic-phase-directed oncolytic therapies, therefore, hinge on gaining a better understanding of latency-to-lytic-phase transition. a key observation in that regard, also common to other herpesviruses, is the partial permissiveness of latently infected cells to lytic-cycle ... | 2015 | 26339061 |
| epstein-barr viruses (ebvs) deficient in ebv-encoded rnas have higher levels of latent membrane protein 2 rna expression in lymphoblastoid cell lines and efficiently establish persistent infections in humanized mice. | functions of epstein-barr virus (ebv)-encoded rnas (ebers) were tested in lymphoblastoid cell lines containing eber mutants of ebv. binding of eber1 to ribosomal protein l22 (rpl22) was confirmed. deletion of eber1 or eber2 correlated with increased levels of cytoplasmic ebv lmp2 rna and with small effects on specific cellular microrna (mirna) levels, but protein levels of lmp1 and lmp2a were not affected. wild-type ebv and eber deletion ebv had approximately equal abilities to infect immunodefi ... | 2015 | 26339045 |
| epstein-barr virus-associated gastric carcinoma: use of host cell machineries and somatic gene mutations. | epstein-barr virus (ebv)-associated gastric carcinoma (ebvagc) is a distinct subtype of gastric carcinoma, consisting of clonal growth of ebv-infected epithelial cells. its unique characteristics have been demonstrated by epidemiological, clinical and pathological studies using in situ hybridization for ebv-encoded small rnas. an oncogenic process for ebvagc has also been revealed. ebv uses various host-cell machineries, including cell division machinery to propagate clonal virus genomes, dna-me ... | 2015 | 26337667 |
| investigation of mir9-1, mir9-2 and mir9-3 methylation in hodgkin lymphoma. | mir9 is an important tumor suppressor microrna regulated by dna methylation in various types of cancers. | 2015 | 26337487 |
| the role of the polycomb repressive complex pathway in t and nk cell lymphoma: biological and prognostic implications. | polycomb repressive complex 2 (prc2; formed by ezh2, suz12, and eed protein subunits) and prc1 (bmi1 protein) induce gene silencing through histone modification, primarily h3k27me3, and deregulation of prc pathways leads to tumorigenesis. in the present study, activation of prc2, h3k27me3, and bmi1 was investigated by immunohistochemistry in 175 cases of t and natural killer (nk) cell lymphoma. activation of prc proteins was analyzed according to c-myc activation, epstein-barr virus (ebv) infect ... | 2016 | 26337274 |
| sequence analysis of epstein-barr virus (ebv) early genes barf1 and bhrf1 in nk/t cell lymphoma from northern china. | nk/t cell lymphoma is an aggressive lymphoma almost always associated with ebv. bamhi-a rightward open reading frame 1 (barf1) and bamhi-h rightward open reading frame 1 (bhrf1) are two ebv early genes, which may be involved in the oncogenicity of ebv. it has been found that v29a strains, a barf1 mutant subtype, showed higher prevalence in npc, which may suggest the association between this variation and nasopharyngeal carcinoma (npc). to characterize the sequence variation patterns of the epste ... | 2015 | 26337172 |
| dissecting the contribution of ebna3c domains important for ebv-induced b-cell growth and proliferation. | epstein-barr virus (ebv) is an oncogenic gammaherpes virus which is linked to pathogenesis of several human lymphatic malignancies. the ebv essential latent antigen ebna3c is critical for efficient conversion of primary human b-lymphocytes to lymphoblastic cell lines and for continued lcl growth. ebna3c, an ebv latent antigen with oncogenic potential can bind and regulate the functions of a wide range of cellular transcription factors. in our current reverse genetics study, we deleted the full l ... | 2015 | 26336822 |
| effect of latent membrane protein 1 expression on overall survival in epstein-barr virus-associated cancers: a literature-based meta-analysis. | latent membrane protein 1 (lmp1) is identified as the main transforming oncoprotein of epstein-barr virus (ebv). lmp1 is frequently expressed in a variety of ebv-associated cancers, including nasopharyngeal carcinoma (npc), non-hodgkin lymphoma (nhl), hodgkin disease (hd), and gastric cancer (gc). however, due to conflicting results, the prognostic value of lmp1 expression on clinical outcomes in ebv-associated cancers remains unclear. we performed a meta-analysis on 32 studies with a total of 3 ... | 2015 | 26336130 |
| inhibition of autophagy in ebv-positive burkitt's lymphoma cells enhances ebv lytic genes expression and replication. | autophagy, an important degradation system involved in maintaining cellular homeostasis, serves also to eliminate pathogens and process their fragments for presentation to the immune system. several viruses have been shown to interact with the host autophagic machinery to suppress or make use of this cellular catabolic pathway to enhance their survival and replication. epstein barr virus (ebv) is a γ-herpes virus associated with a number of malignancies of epithelial and lymphoid origin in which ... | 2015 | 26335716 |
| decreased activation-induced cell death by ebv-transformed b-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel faslg mutation. | autoimmune lymphoproliferative syndrome (alps) is a primary immunodeficiency characterized by chronic lymphoproliferation, autoimmune manifestations, expansion of double-negative t-cells, and susceptibility to malignancies. most cases of alps are caused by germline or somatic fas mutations. we report the case of an alps patient due to a novel homozygous fasligand gene mutation (alps-faslg). | 2015 | 26334989 |
| epstein-barr virus-driven b cell proliferation with cd4+ t cell expansion: a lymphomatoid granulomatosis-like disease related to hyperinterleukin-10 secretion of remarkably favourable outcome with rituximab. | granulomatous lymphomatosis is an epstein-barr virus (ebv)-driven b cell proliferation associated with an exuberant cd4(+) t cell reaction with usually histopathological pictures of angiocentrism. so far, the characteristics of cd4(+) t cells in granulomatous lymphomatosis and the mechanism leading to their expansion remain poorly explored. we report a 56-year-old female with a past history of cold agglutinin disease, which was successfully treated with 4 weekly infusions of rituximab. she prese ... | 2015 | 26332210 |
| clinicopathological features of inflammatory pseudotumour-like follicular dendritic cell tumour of the abdomen. | inflammatory pseudotumour-like follicular dendritic cell (fdc) tumour is an extremely rare neoplasm. herein, we report 10 cases of inflammatory pseudotumour-like fdc tumours in the abdomen and analyse their clinicopathological features. | 2016 | 26332157 |
| angioimmunoblastic t-cell lymphoma presenting with an acute serologic epstein-barr virus profile. | angioimmunoblastic t-cell lymphoma (aitl) is an aggressive peripheral t-cell lymphoma typically characterized by prominent lymphadenopathy and b-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of epstein-barr virus (ebv). lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical t-cells (usually cd4+/cd10+/pd1+) and prominent proliferations of high endo ... | 2015 | 26331002 |
| silicone implants and lymphoma: the role of inflammation. | the risk of hematological malignancies is mainly determined by genetic background, age, sex, race and ethnicity, geographic location, exposure to certain chemicals and radiation; along with the more recently proposed immune factors such as chronic inflammation, immunodeficiencies, autoimmunity, and infections. paradigmatic examples include the development of lymphoma in sjögren's syndrome and hashimoto thyroiditis, gastric malt lymphoma in helicobacter pylori infection, or lymphomas associated w ... | 2015 | 26330346 |
| integrated analysis of the differential cellular and ebv mirna expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues. | nasopharyngeal carcinoma (npc) is commonly diagnosed in southern asia. micrornas (mirnas) are small non-coding rnas that regulate gene expression post-transcriptionally. increasing evidence suggests that the dysregulation of mirnas promotes npc tumorigenesis. epstein-barr virus (ebv) infection and ebv-encoded mirnas are also associated with the development of npc. however, it is unclear how cellular and ebv mirnas jointly regulate target genes and signaling pathways in npc. in the present study, ... | 2015 | 26330189 |
| virus-encoded microrna contributes to the molecular profile of ebv-positive burkitt lymphomas. | burkitt lymphoma (bl) is an aggressive neoplasm characterized by consistent morphology and phenotype, typical clinical behavior and distinctive molecular profile. the latter is mostly driven by the myc over-expression associated with the characteristic translocation (8;14) (q24; q32) or with variant lesions. additional genetic events can contribute to burkitt lymphoma pathobiology and retain clinical significance. a pathogenetic role for epstein-barr virus infection in burkitt lymphomagenesis ha ... | 2016 | 26325594 |
| epigenetic silencing of tumor suppressor genes during in vitro epstein-barr virus infection. | dna-methylation at cpg islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (tsg) silencing mechanisms, widely contribute to the development of multiple human cancers. furthermore, oncogenic viruses, including epstein-barr virus (ebv)-associated human cancers, were also shown to be influenced by epigenetic modifications on the viral and cellular genomes in th ... | 2015 | 26324942 |
| early virological and immunological events in epstein-barr virus infection. | epstein-barr virus (ebv) is a γ-herpesvirus which establishes a chronic yet asymptomatic infection in humans. this saliva transmitted virus has a tropism for b lymphocytes, in which it establishes a latent infection, and epithelial cells where the virus replicates to produce infectious particles. although the majority of infections are apparently benign, primary ebv infection can be associated with an acute febrile syndrome, infectious mononucleosis, while infection is also associated with the d ... | 2015 | 26322696 |
| production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to epstein-barr virus primary infection: a case report of a child. | various autoantibodies have been reported to be detected during the progression of infectious mononucleosis. we observed a case of infectious mononucleosis due to epstein-barr virus primary infection for 2 months, and noticed the transiently increased titer of thyrotropin receptor autoantibodies detected at the acute phase on the 3rd day after admission. at that time, real-time quantitative pcr also revealed the mrna expressions of an immediate early lytic gene, bzlf1, and a latent gene, ebna2. ... | 2015 | 26322262 |
| quantification of epstein-barr virus and human cytomegalovirus in chronic periodontal patients. | although studies focused mainly on the identification of periopathogenic bacteria, recent reports have suggested that various herpes viruses may also be involved in the occurrence and progression of different forms of periodontal diseases. | 2015 | 26322203 |
| possible relations between epstein-barr virus past infection and classic multiple sclerosis in guilan, iran. | multiple sclerosis (ms) is a demyelinating condition affecting the central nervous system. although the cause of this condition is unknown, patients with ms seem to have genetic vulnerability to certain environmental factors such as infection that could trigger this condition. | 2015 | 26322199 |
| epstein-barr virus (ebv)--associated posttransplant lymphoproliferative disorder appearing as mandibular gingival ulcers. | posttransplant lymphoproliferative disorders (ptlds) comprise a spectrum of complications that affect immunocompromised patients following hematopoietic stem cell transplantation or solid organ transplantation. its incidence varies depending on the transplanted organ, occurring in approximately 2.3% of kidney transplantations. a 31-year-old woman was referred to the dental clinic of the state university of western paraná for evaluation of an oral lesion. her medical history revealed a previous d ... | 2016 | 26321430 |
| nasopharyngeal carcinoma. | epidemiological trends during the past decade suggest that although incidence of nasopharyngeal carcinoma is gradually declining, even in endemic regions, mortality from the disease has fallen substantially. this finding is probably a result of a combination of lifestyle modification, population screening coupled with better imaging, advances in radiotherapy, and effective systemic agents. in particular, intensity-modulated radiotherapy has driven the improvement in tumour control and reduction ... | 2016 | 26321262 |
| non hcv-related infectious cryoglobulinemia vasculitis: results from the french nationwide cryovas survey and systematic review of the literature. | in patients with infectious cryoglobulinemia vasculitis (cryovas) in the absence of hepatitis c virus infection, data on presentation, therapeutic management and outcome are lacking. we conducted a nationwide survey that included patients with hcv-negative cryovas. we describe here the presentation, therapeutic management and outcome of 18 patients with non-hcv infectious cryovas and 27 additional patients identified form a systematic review of the literature. we included 18 patients, mean age 5 ... | 2015 | 26320984 |
| peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. | the etiology of multiple sclerosis (ms) involves both genetic and environmental factors. genetically, the strongest link is with hla drb1*1501, but the environmental trigger, probably a virus, remains uncertain. this investigation scans a panel of proteins from encephalitogenic viruses for peptides homologous to the primary autoantigen from myelin basic protein (mbp), then evaluates candidate peptides against a motif required for t cell cross-reactivity and compares viral prevalence patterns to ... | 2015 | 26319106 |
| non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma in the united states: a population-based study. | non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma (lelc) is a rate entity. the purpose of this study was to analyze its demographic, clinicopathologic, and survival characteristics. | 2016 | 26316257 |
| systemic multi-organ involvement in chronic active epstein-barr virus disease. | 2015 | 26315206 | |
| different mechanisms of regulation of the warburg effect in lymphoblastoid and burkitt lymphoma cells. | the warburg effect is one of the hallmarks of cancer and rapidly proliferating cells. it is known that the hypoxia-inducible factor 1-alpha (hif1a) and myc proteins cooperatively regulate expression of the hk2 and pdk1 genes, respectively, in the burkitt lymphoma (bl) cell line p493-6, carrying an inducible myc gene repression system. however, the mechanism of aerobic glycolysis in bl cells has not yet been fully understood. | 2015 | 26312753 |
| host gene expression is regulated by two types of noncoding rnas transcribed from the epstein-barr virus bamhi a rightward transcript region. | in epstein-barr virus-infected epithelial cancers, the alternatively spliced bamhi a rightward transcripts (barts) are the most abundant viral polyadenylated rna. the bart introns form the template for the production of 44 micrornas (mirnas), and the spliced and polyadenylated exons form nuclear non-protein-coding rnas. analysis of host cell transcription by rna-seq during latency in ags cells identified a large number of reproducibly changed genes. genes that were downregulated were enriched fo ... | 2015 | 26311882 |
| l particles transmit viral proteins from herpes simplex virus 1-infected mature dendritic cells to uninfected bystander cells, inducing cd83 downmodulation. | mature dendritic cells (mdcs) are known as the most potent antigen-presenting cells (apcs) since they are also able to prime/induce naive t cells. thus, mdcs play a pivotal role during the induction of antiviral immune responses. remarkably, the cell surface molecule cd83, which was shown to have costimulatory properties, is targeted by herpes simplex virus 1 (hsv-1) for viral immune escape. infection of mdcs with hsv-1 results in downmodulation of cd83, resulting in reduced t cell stimulation. ... | 2015 | 26311871 |
| the long-lasting love affair between the budding yeast saccharomyces cerevisiae and the epstein-barr virus. | the epstein-barr gammaherpesvirus (ebv) is the first oncogenic virus discovered in human. indeed, ebv has been known for more than 50 years to be tightly associated with certain human cancers. as such, ebv has been the subject of extensive studies aiming at deciphering various aspects of its biological cycle, ranging from the regulation of its genome replication and maintenance to the induction of its lytic cycle, including the mechanisms that allow its immune evasion or that are related to its ... | 2015 | 26311489 |
| non-epstein-barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review. | a 55-year-old chinese male was admitted to the hospital for epigastralgia and dysphagia with a two month history, and hematemesis and melena with a two-day history. two lesions were found in the esophagus and stomach by esophago--gastroduodenoscopy and computed tomography. the patient underwent subtotal esophagectomy and gastrectomy, esophagogastric anastomosis above the aortic arch, and thoracic-abdominal two-field lymph node dissection. pathological and immumohistochemical studies showed that ... | 2015 | 26309699 |
| clinical characteristics and laboratory findings in danish children hospitalized with primary epstein-barr virus infection. | epstein-barr virus (ebv) positive infectious mononucleosis (im) is a common disease in adolescents. however, im is often considered a rare disease in early childhood. we aimed to describe the classical presentation of adolescent ebv-associated im compared to ebv infection at younger age. | 2015 | 26308113 |
| anti-tnfα therapy for inflammatory bowel diseases is associated with epstein-barr virus lytic activation. | anti-tnfα therapy, known to suppress t-cell immunity, is increasingly gaining popularity for treatment of autoimmune diseases including inflammatory bowel diseases (ibd). t-cell suppression increases the risk of b-cell ebv-lymphoproliferative diseases and lymphomas. since ebv-lytic activation is essential for development of ebv-lymphomas and there have been reports of ebv-lymphomas in patients treated with anti-tnfα therapy, we investigated if patients treated with anti-tnfα antibodies demonstra ... | 2016 | 26307954 |
| evasion of affinity-based selection in germinal centers by epstein-barr virus lmp2a. | epstein-barr virus (ebv) infects germinal center (gc) b cells and establishes persistent infection in memory b cells. ebv-infected b cells can cause b-cell malignancies in humans with t- or natural killer-cell deficiency. we now find that ebv-encoded latent membrane protein 2a (lmp2a) mimics b-cell antigen receptor (bcr) signaling in murine gc b cells, causing altered humoral immune responses and autoimmune diseases. investigation of the impact of lmp2a on b-cell differentiation in mice that con ... | 2015 | 26305967 |
| approaches for monitoring of non virus-specific and virus-specific t-cell response in solid organ transplantation and their clinical applications. | opportunistic viral infections are still a major complication following solid organ transplantation. immune monitoring may allow the identification of patients at risk of infection and, eventually, the modulation of immunosuppressive strategies. immune monitoring can be performed using virus-specific and non virus-specific assays. this article describes and summarizes the pros and cons of the different technical approaches. among the assays based on non virus-specific antigens, the enumeration o ... | 2015 | 26305832 |
| performance of a new rapid test for detecting anti-hepatitis e virus immunoglobulin m in immunocompetent and immunocompromised patients. | hepatitis e virus (hev) infections are widespread in both developing and developed countries. it is, therefore, important to assess the performance of systems for rapidly detecting anti-hev immunoglobulin m antibodies in human sera. | 2015 | 26305830 |
| detection of nasopharyngeal carcinoma in morocco (north africa) using a multiplex methylation-specific pcr biomarker assay. | silencing of tumor suppressor genes (tsgs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. the methylation status of such genes can be used for early detection of cancer. we are pursuing this approach in our efforts to develop markers for early detection and follow-up of nasopharyngeal carcinoma (npc). we set out to develop this approach to allow identification of npc from morocco and then also compared with npc samples from differen ... | 2015 | 26300994 |
| rare variants in the spectrum of human herpesvirus 8/epstein-barr virus-copositive lymphoproliferations. | we report 2 rare variants in the spectrum of human herpesvirus 8 (hhv8)/epstein-barr virus (ebv)-copositive lymphoproliferations arising in hiv-seronegative patients, including a large b-cell lymphoma arising in the setting of multicentric castleman disease and a germinotropic lymphoproliferative disorder. in the first case, histology revealed features of multicentric castleman disease and a proliferation of large lymphoid cells forming clusters or arcs or rings replacing the periphery of follic ... | 2015 | 26299509 |
| establishment and characterization of a cd20-positive nk/t-cell lymphoma cell line. | cd20 positive nk/t-cell lymphoma is extremely rare and difficult for clinical treatment. due to the lack of an established cell model for this disease, less is known about its biological characterization and potential therapeutic options. | 2015 | 26299072 |
| ebv epiglottitis: primary supraglottic viral infection in a pediatric immunocompetent host. | in this report we describe a case in which a previously healthy 7 year-old male developed acute epiglottitis secondary to epstein-barr virus (ebv) infection. this patient required fiberoptic intubation and icu stay. we discuss epiglottitis diagnosis and management with ebv as the primary etiologic agent. | 2015 | 26298621 |
| a rare case of non-epstein-barr virus-associated lymphoepithelioma-like carcinoma of the esophagus treated with endoscopic submucosal dissection. | 2016 | 26297869 | |
| transcriptional activation of epstein-barr virus brlf1 by usf1 and rta. | during its lytic cycle, epstein-barr virus (ebv) expresses rta, a factor encoded by brlf1 that activates the transcription of viral lytic genes. we found that upstream stimulating factor (usf) binds to e1, one of the five e boxes located at - 79 in the brlf1 promoter (rp), to activate brlf1 transcription. furthermore, rta was shown to interact with usf1 in coimmunoprecipitation and glutathione s-transferase (gst)-pulldown assays, and confocal laser-scanning microscopy further confirmed that thes ... | 2015 | 26297580 |
| production and characterisation of epstein-barr virus helicase-primase complex and its accessory protein bblf2/3. | the helicase-primase complex is part of the lytic dna replication machinery of herpesviruses, but up to now, almost nothing is known about its structure. for epstein-barr virus it consists in the helicase bblf4, the primase bslf1 and the accessory protein bblf2/3. the accessory protein shows only weak sequence homology within the herpesvirus family but may be related to an inactive b-family polymerase. bslf1 belongs to the archaeo-eukaryotic primase family, whereas the helicase bblf4 has been re ... | 2015 | 26292944 |
| multifunctional non-coding epstein-barr virus encoded rnas (ebers) contribute to viral pathogenesis. | epstein-barr virus (ebv) is known as an oncogenic herpesvirus implicated in the pathogenesis of various malignancies. it has been reported that ebv non-coding rnas (ncrnas) including ebv-encoded small rnas (ebers) and ebv-mirnas contribute to viral pathogenesis. ebers that are expressed abundantly in latently ebv-infected cells have been reported to play significant roles in tumorigenesis by ebv. furthermore, it was demonstrated that the modulation of host innate immune signals by ebers contribu ... | 2016 | 26292159 |
| lymphocytic arteritis in epstein-barr virus vulvar ulceration (lipschütz disease): a report of 7 cases. | epstein-barr virus (ebv) infection can rarely present as painful genital ulcers, mostly in young female adolescents. typically diagnosed by clinical findings, ebv vulvar ulceration (ebvvu) is rarely biopsied. herein, the authors report the histopathology in 8 biopsies from 7 ebvvu patients, all serologically confirmed for acute (4/7) or reactivated-chronic (3/7) ebv infection. the 7 women all presented with 1 or more painful, punched-out vulvar ulcers. only patients with acute ebv infection show ... | 2015 | 26291418 |
| nonmuscle myosin heavy chain iia mediates epstein-barr virus infection of nasopharyngeal epithelial cells. | ebv causes b lymphomas and undifferentiated nasopharyngeal carcinoma (npc). although the mechanisms by which ebv infects b lymphocytes have been extensively studied, investigation of the mechanisms by which ebv infects nasopharyngeal epithelial cells (npecs) has only recently been enabled by the successful growth of b lymphoma mo-mlv insertion region 1 homolog (bmi1)-immortalized npecs in vitro and the discovery that neuropilin 1 expression positively affects ebv glycoprotein b (gb)-mediated inf ... | 2015 | 26290577 |
| multicenter study of combination dep regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a refractory immune disorder with a significant risk of death. although standard therapy has dramatically improved survival in hlh patients, approximately 30%, especially adults, show no response to current treatment strategies. this prospective study aimed to investigate the efficacy of liposomal doxorubicin treatment combined with etoposide and methylprednisolone (doxorubicin-etoposide-methylprednisolone; dep) as a salvage therapy for adult refractor ... | 2015 | 26289641 |
| the presence of human papillomavirus and epstein-barr virus in male chinese lichen sclerosus patients: a single center study. | this study aimed to investigate the presence of human papillomavirus and epstein-barr virus in male lichen sclerosus patients. we extracted dna from formalin-fixed paraffin-embedded foreskin tissue blocks of 47 male ls patients and 30 healthy men and performed real-time pcr test to detect hpv and ebv. none of the 47 ls patients and 30 healthy men had detectable hpv infection. ebv was detected in 18 ls patients (38.3%) and four healthy men (13.3%), the difference is significant (p < 0.05). tissue ... | 2017 | 26289401 |
| epstein-barr virus micrornas are expressed in patients with chronic lymphocytic leukemia and correlate with overall survival. | although numerous studies highlighted the role of epstein-barr virus (ebv) in b-cell transformation, the involvement of ebv proteins or genome in the development of the most frequent adult leukemia, chronic lymphocytic leukemia (cll), has not yet been defined. we hypothesized that ebv micrornas contribute to progression of cll and demonstrated the presence of ebv mirnas in b-cells, in paraffin-embedded bone marrow biopsies and in the plasma of patients with cll by using three different methods ( ... | 2015 | 26288818 |
| viral etiology, clinical and laboratory features of adult hemophagocytic lymphohistiocytosis. | secondary hemophagocytic lymphohistiocytosis (shlh) is a potentially fatal hyperinflammatory syndrome with a heterogeneous etiology and has nonspecific clinical and laboratory findings. the diagnosis and treatment of adult shlh is challenging because the etiology of the disease is difficult to identify, and the majority of reported cases are pediatric patients. the aim of this study was to describe the etiology, clinical characteristics, and outcomes of adult shlh. fifty-four adult patients who ... | 2016 | 26287378 |
| fistulizing epstein-barr virus-positive plasmablastic lymphoma in an hiv-positive man. | plasmablastic lymphoma (pbl) is an unusual subtype of non-hodgkin lymphoma recently classified as a diffuse immunoblastic lymphoma with a plasma-cell immunophenotype. originally described in the oral cavity of hiv-positive patients, it has also been recognized to occur rarely at other sites. we describe a previously unreported fistulizing presentation of epstein-barr virus (ebv)-positive pbl, reviewing its association with hiv-1 infection and its importance as an aids-defining malignancy. | 2016 | 26286218 |
| hpv and ebv infections in neck metastases from occult primary squamous cell carcinoma: another virus-related neoplastic disease in the head and neck region. | approximately 1-9 % of all head and neck squamous cell carcinomas are neck metastases from clinically undetectable primary tumors. human papillomavirus (hpv) and epstein-barr virus (ebv) are proven carcinogenic factors that are associated with oropharyngeal squamous cell carcinoma and nasopharyngeal carcinoma, respectively. in the present study, we evaluated the prevalence of these viruses in neck metastases from unknown primary squamous cell carcinoma. | 2015 | 26286196 |
| post-transplant lymphoproliferative disorder (ptld) manifesting in the oral cavity of a 13-year-old liver transplant recipient (ltx). | background post-transplant lymphoproliferative disorder (ptld) is a potential complication of solid organ or bone marrow transplants. the main ptld risk factors are: the epstein-barr virus (ebv), transplant type, and use of immunosuppressants. it mainly consists of an uncontrolled growth of lymphocytes in transplant recipients under chronic immunosuppressive therapy. about 85% of ptlds are ebv-containing b-cell proliferations; 14% are t-cell proliferations, of which only 40% contain ebv; and the ... | 2015 | 26285106 |