Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| spontaneous arterial hemorrhage as a complication of dengue. | bleeding complications of dengue hemorrhagic fever such as epistaxis, gum bleeding, gastrointestinal bleeding, hypermenorrhea, hematuria, and thrombocytopenia have been documented. a 49-year-old female presented with complaints of intermittent high-grade fever for the past 4 days, lower abdominal pain and altered sensorium for 1 day. laboratory investigations revealed severe anemia, mild thrombocytopenia, hypofibrinogenemia, and positive dengue serology. emergency ultrasound examination of the a ... | 0 | 27275081 |
| leucokinin mimetic elicits aversive behavior in mosquito aedes aegypti (l.) and inhibits the sugar taste neuron. | insect kinins (leucokinins) are multifunctional peptides acting as neurohormones and neurotransmitters. in females of the mosquito vector aedes aegypti (l.), aedeskinins are known to stimulate fluid secretion from the renal organs (malpighian tubules) and hindgut contractions by activating a g protein-coupled kinin receptor designated "aedae-kr." we used protease-resistant kinin analogs 1728, 1729, and 1460 to evaluate their effects on sucrose perception and feeding behavior. in no-choice feedin ... | 2016 | 27274056 |
| population genetics of the asian tiger mosquito aedes albopictus, an invasive vector of human diseases. | the asian tiger mosquito aedes albopictus is currently one of the most threatening invasive species in the world. native to southeast asia, the species has spread throughout the world in the past 30 years and is now present in every continent but antarctica. because it was the main vector of recent dengue and chikungunya outbreaks, and because of its competency for numerous other viruses and pathogens such as the zika virus, a. albopictus stands out as a model species for invasive diseases vecto ... | 2016 | 27273325 |
| tetrapyrroles as endogenous tspo ligands in eukaryotes and prokaryotes: comparisons with synthetic ligands. | the 18 kda translocator protein (tspo) is highly 0conserved in eukaryotes and prokaryotes. since its discovery in 1977, numerous studies established the tspo's importance for life essential functions. for these studies, synthetic tspo ligands typically are applied. tetrapyrroles present endogenous ligands for the tspo. tetrapyrroles are also evolutionarily conserved and regulate multiple functions. tspo and tetrapyrroles regulate each other. in animals tspo-tetrapyrrole interactions range from e ... | 2016 | 27271616 |
| toxicology of potassium channel-directed compounds in mosquitoes. | potential targets for new vector control insecticides are nerve and muscle potassium channels. in this study, the activities of known potassium channel blockers (4-aminopyridine, quinidine, and tetraethylammonium) and the insecticide propoxur were compared to three experimental catechols and several other compounds against anopheles gambiae and aedes aegypti mosquitoes. experimental catechol 1 was the most toxic experimental compound in all of the mortality assays conducted, but was at least 100 ... | 2016 | 27262624 |
| vector competence of aedes albopictus and aedes aegypti (diptera: culicidae) for the den2-fj10 and den2-fj11 strains of the dengue 2 virus in fujian, china. | dengue is an acute, emerging, infectious disease transmitted by aedes mosquitoes that has become a serious global public health problem. the den2-fj10 and den2-fj11 strains of the dengue 2 virus were originally isolated from the serum of a patient with dengue fever in fujian province, china, in 1999. our data provide the first assessment of the vector competence of aedes mosquitoes with respect to the den2-fj10 and den2-fj11 strains of the dengue virus. there were significant differences in the ... | 2016 | 27260668 |
| seeing is believing: the nocturnal malarial mosquito anopheles coluzzii responds to visual host-cues when odour indicates a host is nearby. | the immediate aim of our study was to analyse the behaviour of the malarial mosquito anopheles coluzzii (an. gambiae species complex) near a human host with the ultimate aim of contributing to our fundamental understanding of mosquito host-seeking behaviour and the overall aim of identifying behaviours that could be exploited to enhance sampling and control strategies. | 2016 | 27260254 |
| epidemiological and virological characterizations of the 2014 dengue outbreak in guangzhou, china. | dengue used to be recognized as an imported and sporadic disease in china. since june 2014, an unexpected large dengue outbreak has attacked guangzhou, china, resulting in more than 40,000 cases. among the 1,942 laboratory-confirmed hospitalized dengue cases, 121 were diagnosed as severe dengue according to the 2009 who guideline, and 2 patients finally died. laboratory diagnosis and virus isolation demonstrated that the majority (96%) cases were caused by dengue virus serotype 1 (denv-1), and t ... | 2016 | 27257804 |
| dengue, chikungunya … and the missing entity - zika fever: a new emerging threat. | zika virus (zikv), a relative newcomer from the flavivirus group that includes dengue, japanese encepahalitis and yellow fever, is one of the emerging pathogens that is fast transcending geographical boundaries. it is a vector-borne disease transmitted by the same aedes aegypti and aedes albopictus, which cause dengue and chikungunya. in addition to the vector-mediated transmission of zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal ... | 2016 | 27257326 |
| crowdsourcing vector surveillance: using community knowledge and experiences to predict densities and distribution of outdoor-biting mosquitoes in rural tanzania. | lack of reliable techniques for large-scale monitoring of disease-transmitting mosquitoes is a major public health challenge, especially where advanced geo-information systems are not regularly applicable. we tested an innovative crowd-sourcing approach, which relies simply on knowledge and experiences of residents to rapidly predict areas where disease-transmitting mosquitoes are most abundant. guided by community-based resource persons, we mapped boundaries and major physical features in three ... | 2016 | 27253869 |
| evaluation of sublethal effects of ipomoea cairica linn. extract on life history traits of dengue vectors. | plant derived insecticides have considerable potential for mosquito control because these products are safer than conventional insecticides. this study aimed to investigate sublethal activities of ipomoea carica or railway creeper crude acethonilic extract against life history trait of dengue vectors, aedes albopictus and aedes aegypti. the late third instar larvae of ae. albopictus and ae. aegypti were exposed to a sublethal dose at lc50 and larvae that survived were further cultured. overall, ... | 2016 | 27253746 |
| myo-inositol phosphate synthase expression in the european eel (anguilla anguilla) and nile tilapia (oreochromis niloticus): effect of seawater acclimation. | a single mips gene (isyna1/ino1) exists in eel and tilapia genomes with a single myo-d-inositol 3-phosphate synthase (mips) transcript identified in all eel tissues, although two mips spliced variants [termed mips(s) and mips(l)] are found in all tilapia tissues. the larger tilapia transcript [mips(l)] results from the inclusion of the 87-nucleotide intron between exons 5 and 6 in the genomic sequence. in most tilapia tissues, the mips(s) transcript exhibits much higher abundance (generally >10- ... | 2016 | 27252471 |
| attractiveness of volatiles from different body parts to the malaria mosquito anopheles coluzzii is affected by deodorant compounds. | mosquitoes display biting preferences among different sites of the human body. in addition to height or convection currents, body odour may play a role in the selection of these biting sites. previous studies have shown that skin emanations are important host-finding cues for mosquitoes. in this study, skin emanations were collected from armpits, hands and feet; the volatile profiles were analysed and tested for their attractiveness to the malaria mosquito anopheles coluzzii. skin emanations col ... | 2016 | 27251017 |
| larvicidal and adulticidal activity of chroman and chromene analogues against susceptible and permethrin-resistant mosquito strains. | mosquitoes play a major role as vectors that transmit parasitic and viral diseases worldwide, especially in tropical and subtropical countries. mosquito borne diseases not only affect humans but they also affect livestock in many parts of the world. they carry diseases that are lethal to dogs and horses. dog heartworm disease (dirofilaria immitis) is a parasitic disease spread through mosquitoes. this disease is not limited to dogs, but it can affect other animals and humans as well. eastern equ ... | 2016 | 27249182 |
| control of urban zika vectors: should we return to the successful paho/who strategy? | 2016 | 27249063 | |
| evaluation of alternative killing agents for aedes aegypti (diptera: culicidae) in the gravid aedes trap (gat). | the gravid aedes trap (gat) uses visual and olfactory cues to attract gravid aedes aegypti (l.) that are then captured when knocked down by a residual pyrethroid surface spray. however, the use of surface sprays can be compromised by poor availability of the spray and pesticide resistance in the target mosquito. we investigated several "alternative" insecticide and insecticide-free killing agents for use in the gat. this included long-lasting insecticide-impregnated nets (llins), vapor-active sy ... | 2016 | 27247350 |
| combinatorial gene regulatory functions underlie ultraconserved elements in drosophila. | ultraconserved elements (uces) are discrete genomic elements conserved across large evolutionary distances. although uces have been linked to multiple facets of mammalian gene regulation their extreme evolutionary conservation remains largely unexplained. here, we apply a computational approach to investigate this question in drosophila, exploring the molecular functions of more than 1,500 uces shared across the genomes of 12 drosophila species. our data indicate that drosophila uces are hubs fo ... | 2016 | 27247329 |
| antifilarial activity of diterpenoids from taxodium distichum. | lymphatic filariasis caused by wuchereria bancrofti, brugia malayi and b. timori, is a debilitating disease with an adverse social and economic impact. the infection remains unabated in spite of treatment with existing antifilarial drugs diethylcarbamazine (dec) and ivermectin which are chiefly microfilaricides. there is therefore, need for macrofilaricides, embryostatic agents and better microfilaricides. in the present study we explored the antifilarial potential of crude extract and its molec ... | 2016 | 27245322 |
| scoping review of the zika virus literature. | the global primary literature on zika virus (zikv) (n = 233 studies and reports, up to march 1, 2016) has been compiled using a scoping review methodology to systematically identify and characterise the literature underpinning this broad topic using methods that are documented, updateable and reproducible. our results indicate that more than half the primary literature on zikv has been published since 2011. the articles mainly covered three topic categories: epidemiology of zikv (surveillance an ... | 2016 | 27244249 |
| wolbachia infections in natural anopheles populations affect egg laying and negatively correlate with plasmodium development. | the maternally inherited alpha-proteobacterium wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. here we study the reproductive manipulations induced by a recently identified wolbachia strain that stably infects natural mosquito populations of a major malaria vector, anopheles coluzzii, in burkina faso. we determine that these infections significantly accelerate egg laying but do not induce cytoplasmic incompati ... | 2016 | 27243367 |
| species composition and habitat characterization of mosquito (diptera: culicidae) larvae in semi-urban areas of dhaka, bangladesh. | mosquito larvae are purely aquatic and develop in water bodies, the type of which is more or less specific to each species. therefore, a study was carried out to identify the habitat characters of different mosquito species along with their species composition in semi-urban area of dhaka in bangladesh during the month of may and june 2012. a total of 6088 mosquito larvae belonging to 12 species (aedes aegypti, aedes albopictus, anopheles barbirostris, anopheles peditaeniatus, anopheles vagus, cu ... | 2016 | 27241953 |
| a novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection. | dengue virus (denv) is a mosquito-borne flavivirus that causes significant human disease and mortality in the tropics and subtropics. by examining the effects of virus infection on gene expression, and interactions between virus and vector, new targets for prevention of infection and novel treatments may be identified in mosquitoes. we previously performed a microarray analysis of the aedes aegypti transcriptome during infection with denv and found that mosquito ubiquitin protein ub3881 (aael003 ... | 2016 | 27241849 |
| synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus. | high-throughput screening of a subset of the cd3 chemical library (centre for drug design and discovery; ku leuven) provided us with a lead compound 1, displaying low micromolar potency against dengue virus and yellow fever virus. within a project aimed at discovering new inhibitors of flaviviruses, substitution of its central imidazole ring led to synthesis of variably substituted pyrazine dicarboxylamides and phthalic diamides, which were evaluated in cell-based assays for cytotoxicity and ant ... | 2016 | 27240271 |
| global distribution and environmental suitability for chikungunya virus, 1952 to 2015. | chikungunya fever is an acute febrile illness caused by the chikungunya virus (chikv), which is transmitted to humans by aedes mosquitoes. although chikungunya fever is rarely fatal, patients can experience debilitating symptoms that last from months to years. here we comprehensively assess the global distribution of chikungunya and produce high-resolution maps, using an established modelling framework that combines a comprehensive occurrence database with bespoke environmental correlates, inclu ... | 0 | 27239817 |
| zika virus infection: current concerns and perspectives. | the zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect zika virus, as it is often recognized as a mild disease without being identified. many zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. the aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic ... | 2016 | 27236440 |
| a glance at subgenomic flavivirus rnas and micrornas in flavivirus infections. | the family flaviviridae comprises a wide variety of viruses that are distributed worldwide, some of which are associated with high rates of morbidity and mortality. there are neither vaccines nor antivirals for most flavivirus infections, reinforcing the importance of research on different aspects of the viral life cycle. during infection, cytoplasmic accumulation of rna fragments mainly originating from the 3' utrs, which have been designated subgenomic flavivirus rnas (sfrnas), has been detect ... | 2016 | 27233361 |
| chikungunya virus infection of aedes mosquitoes. | in vivo infection of mosquitoes is an important method to study and characterize arthropod-borne viruses. chikungunya virus (chikv) is a mosquito-borne alphavirus that is transmitted primarily by aedes mosquitoes. in this chapter, we describe a protocol for infection of chikv in two species of aedes mosquitoes, aedes aegypti and aedes albopictus, together with the isolation of chikv in different parts of the infected mosquito such as midgut, legs, wings, salivary gland, head, and saliva. this al ... | 2016 | 27233266 |
| utilization and assessment of throat swab and urine specimens for diagnosis of chikungunya virus infection. | chikungunya is a mosquito-borne infection with clinical presentation of fever, arthralgia, and rash. the etiological agent chikungunya virus (chikv) is generally transmitted from primates to humans through the bites of infected aedes aegypti and aedes albopictus mosquitoes. outbreaks of chikungunya occur commonly with varied morbidity, mortality, and sequele according to the epidemiological, ecological, seasonal, and geographical impact. investigations are required to be conducted as a part of t ... | 2016 | 27233262 |
| outwitting dengue threat and epidemics resurgence in asia-pacific countries: strengthening integrated dengue surveillance, monitoring and response systems. | dengue is still a substantial vector-borne viral disease threat and burden of public health importance worldwide. this situation is complicated by dengue virus unprecedented resurgence and persistence of varied serotypes in endemic-prone areas, and man-made and natural activities consequences that promote vector emergence, transmission dynamics and spread across the asia-pacific region. there is an urgent need to strengthen operational and contextual surveillance-response research in improving e ... | 2016 | 27233238 |
| correction: spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | [this corrects the article doi: 10.1371/journal.pntd.0004664.]. | 2016 | 27232603 |
| first case of zika virus infection in a hiv+ patient. | zika virus is an enveloped, single-stranded rna virus that belongs to the flavivirus genre. as with arbovirus, it is transmitted by arthropods (mosquitoes), both aedes aegypti (urban) and albopictus (rural). zika virus was first isolated in 1947 from monkeys in uganda. the first human cases were reported in 1952 in east africa. outbreaks were reported in micronesia (2007), polynesia (2013), and chile (2014). both diagnostic procedures and therapeutics are poorly developed. serological tests cros ... | 2017 | 27232506 |
| effects of temperature on the life cycle, expansion, and dispersion of aedes aegypti (diptera: culicidae) in three cities in paraiba, brazil. | the mosquito aedes aegypti is the primary vector of dengue and is common throughout tropical and subtropical regions. its distribution is modulated by environmental factors, such as temperature. this study aimed to evaluate the influence of temperature on the life cycle and expansion of ae. aegypti populations in the cities of campina grande, joão pessoa, and patos. samples of ae. aegypti were collected in the three cities and raised in the laboratory. we assessed the life cycles of the three ae ... | 2016 | 27232118 |
| zika in the united states of america and a fateful 1969 decision. | the united states gulf coast's current risk to zika transmitted by aedes aegypti mosquitoes can be traced back to some important federal health policy decisions made during the 1960s. | 2016 | 27227971 |
| projected impact of dengue vaccination in yucatán, mexico. | dengue vaccines will soon provide a new tool for reducing dengue disease, but the effectiveness of widespread vaccination campaigns has not yet been determined. we developed an agent-based dengue model representing movement of and transmission dynamics among people and mosquitoes in yucatán, mexico, and simulated various vaccine scenarios to evaluate effectiveness under those conditions. this model includes detailed spatial representation of the yucatán population, including the location and mov ... | 2016 | 27227883 |
| different effects of metarhizium anisopliae strains imi330189 and ibc200614 on enzymes activities and hemocytes of locusta migratoria l. | metarhizium is an important class of entomopathogenic fungi in the biocontrol of insects, but its virulence is affected by insect immunity. to clarify the mechanism in virulence of metarhizium, we compared the immunological differences in locusta migratoria l. when exposed to two strains of metarhizium anisopliae (ma). | 2016 | 27227835 |
| quantifying the epidemiological impact of vector control on dengue. | 2016 | 27227829 | |
| species-specific temperature sensitivity of trpa1. | transient receptor potential ankyrin 1 (trpa1) is a polymodal ion channel sensitive to temperature and chemical stimuli. the importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of trpa1 sensitivity. this diversity can be observed in the various roles of trpa1 in different species, where it is proposed to act as a temperature-insensitive chemosensor, a heat transducer, a noxious cold transducer, or a detector of low-intensity heat for prey ... | 2015 | 27227025 |
| evocation to the dr. carlos j. finlay barres on the centennial of his death. | about the editorial of the professor guillermo llanos: "carlos j. finlay: the forgotten pasteur of america", a hundred years after his death and through a documental review, a summary of the life and work of this great man of science was conducted. finlay was a notable figure of the american medicine, he conceived a new infection way able to explain the propagation of the yellow fever, and added the possibility of their scientific confirmation by an experimental method. for all the above-mention ... | 2016 | 27226667 |
| emerging infectious disease and fast-track publication: when public health gets priority over the formality of scholarly publishing. | 0 | 27223865 | |
| temporal dynamics and spatial patterns of aedes aegypti breeding sites, in the context of a dengue control program in tartagal (salta province, argentina). | since 2009, fundación mundo sano has implemented an aedes aegypti surveillance and control program in tartagal city (salta province, argentina). the purpose of this study was to analyze temporal dynamics of ae. aegypti breeding sites spatial distribution, during five years of samplings, and the effect of control actions over vector population dynamics. | 2016 | 27223693 |
| primary dengue haemorrhagic fever in patients from northeast of brazil is associated with high levels of interferon-β during acute phase. | dengue is an acute febrile disease caused by the mosquito-borne dengue virus (denv) that according to clinical manifestations can be classified as asymptomatic, mild or severe dengue. severe dengue cases have been associated with an unbalanced immune response characterised by an over secretion of inflammatory cytokines. in the present study we measured type i interferon (ifn-i) transcript and circulating levels in primary and secondary denv infected patients. we observed that dengue fever (df) a ... | 0 | 27223651 |
| molecular identification of mosquitoes (diptera: culicidae) in southeastern australia. | dna barcoding is a modern species identification technique that can be used to distinguish morphologically similar species, and is particularly useful when using small amounts of starting material from partial specimens or from immature stages. in order to use dna barcoding in a surveillance program, a database containing mosquito barcode sequences is required. this study obtained cytochrome oxidase i (coi) sequences for 113 morphologically identified specimens, representing 29 species, six trib ... | 2016 | 27217948 |
| the effect of wolbachia on dengue outbreaks when dengue is repeatedly introduced. | use of the wolbachia bacterium is a proposed new strategy to reduce dengue transmission, which results in around 390 million individuals infected annually. in places with strong variations in climatic conditions such as temperature and rainfall, dengue epidemics generally occur only at a certain time of the year. where dengue is not endemic, the time of year in which imported cases enter the population plays a crucial role in determining the likelihood of outbreak occurrence. we use a mathematic ... | 2016 | 27217229 |
| meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections. | dengue virus (denv) infection is currently a major cause of morbidity and mortality in the world; it has become more common and virulent over the past half-century and has gained much attention. thus, this review compared the percentage of severe cases of both primary and secondary infections with different serotypes of dengue virus. | 2016 | 27213782 |
| functional and biochemical characterization of three recombinant human glucose-6-phosphate dehydrogenase mutants: zacatecas, vanua-lava and viangchan. | glucose-6-phosphate dehydrogenase (g6pd) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. in order to understand the effect of the mutations in g6pd gene function and its relation with g6pd deficiency severity, we report the construction, cloning and expression as well as the detailed kinetic and stability characterization of three purified clinical ... | 2016 | 27213370 |
| clinical profile of dengue fever in children: a study from southern odisha, india. | background. in india, dengue epidemics are becoming more frequent (who, 2008). the majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. objectives. to assess the clinical profile of the dengue infection in children less than 14 years of age and to evaluate the outcomes of dengue fever from september 2013 to august 2015 at the pediatric department of maharaja krishna chandra gajapati medical college, the largest tertiary care hospital of ... | 2016 | 27213083 |
| flavivirus vaccines: innovate, invest, implement. | 2016 | 27211530 | |
| highly diversified zika viruses imported to china, 2016. | 0 | 27209301 | |
| yellow fever vaccination status and safety in hemodialysis patients. | the adverse effects of yellow fever (yf) vaccine in dialysis patients are not well known. there is concern about the risks and benefits of the vaccine in immunocompromised patients living in endemic areas, particularly given the risk of resurgence of urban yf with the spread of aedes aegypti mosquitoes. the purpose of this study was to assess the coverage and safety of yf vaccine in chronic dialysis patients. | 2016 | 27208638 |
| a cost-effectiveness tool for informing policies on zika virus control. | as zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. for example, to combat the current zika outbreak the us president requested the allocation of $1.8 billion from congress in february 2016. | 2016 | 27205899 |
| exposure to aedes aegypti bites induces a mixed-type allergic response following salivary antigens challenge in mice. | classical studies have shown that aedes aegypti salivary secretion is responsible for the sensitization to mosquito bites and many of the components present in saliva are immunogenic and capable of inducing an intense immune response. therefore, we have characterized a murine model of adjuvant-free systemic allergy induced by natural exposure to mosquito bites. balb/c mice were sensitized by exposure to a. aegypti mosquito bites and intranasally challenged with phosphate-buffered saline only or ... | 2016 | 27203689 |
| experimental infection of rhodnius prolixus (hemiptera, triatominae) with mycobacterium leprae indicates potential for leprosy transmission. | leprosy is a chronic dermato-neurological disease caused by infection with mycobacterium leprae. in 2013 almost 200,000 new cases of leprosy were detected around the world. since the first symptoms take from years to decades to appear, the total number of asymptomatic patients is impossible to predict. although leprosy is one of the oldest records of human disease, the mechanisms involved with its transmission and epidemiology are still not completely understood. in the present work, we experime ... | 2016 | 27203082 |
| an infectious cdna clone of zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. | the asian lineage of zika virus (zikv) has recently caused epidemics and severe disease. unraveling the mechanisms causing increased viral transmissibility and disease severity requires experimental systems. we report an infectious cdna clone of zikv that was generated using a clinical isolate of the asian lineage. the cdna clone-derived rna is infectious in cells, generating recombinant zikv. the recombinant virus is virulent in established zikv mouse models, leading to neurological signs relev ... | 2016 | 27198478 |
| urban climate versus global climate change-what makes the difference for dengue? | the expansion in the geographical distribution of vector-borne diseases is a much emphasized consequence of climate change, as are the consequences of urbanization for diseases that are already endemic, which may be even more important for public health. in this paper, we focus on dengue, the most widespread urban vector-borne disease. largely urban with a tropical/subtropical distribution and vectored by a domesticated mosquito, aedes aegypti, dengue poses a serious public health threat. temper ... | 2016 | 27197685 |
| estimated zika virus importations to europe by travellers from brazil. | given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. | 2016 | 27193266 |
| molecular characterization and function analysis of the vitellogenin receptor from the cotton bollworm, helicoverpa armigera (hübner) (lepidoptera, noctuidae). | developing oocytes accumulate plentiful yolk protein during oogenesis through receptor-mediated endocytosis. the vitellogenin receptor (vgr), belonging to the low-density lipoprotein receptor (ldlr) family, regulates the absorption of yolk protein. in this work, the full-length vitellogenin receptor (havgr) in the cotton bollworm helicoverpa armigera was identified, encoding a 1817 residue protein. sequence alignment revealed that the sequence of havgr contained all of the conservative structura ... | 2016 | 27192057 |
| reemergence of dengue in southern texas, 2013. | during a dengue epidemic in northern mexico, enhanced surveillance identified 53 laboratory-positive cases in southern texas; 26 (49%) patients acquired the infection locally, and 29 (55%) were hospitalized. of 83 patient specimens that were initially igm negative according to elisa performed at a commercial laboratory, 14 (17%) were dengue virus positive by real-time reverse transcription pcr performed at the centers for disease control and prevention. dengue virus types 1 and 3 were identified ... | 0 | 27191223 |
| mathematical model of three age-structured transmission dynamics of chikungunya virus. | we developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus. the model is analyzed to gain insights into the qualitative features of its associated equilibria. some of the theoretical and epidemiological findings indicate that the stable disease-free equilibrium is globally asymptotically stable when the associated reproduction number is less than unity. furthermore, the model undergoes, in the presence of disease induced mortality, the phenomenon of ... | 2016 | 27190548 |
| magnitude of neglected tropical diseases in indonesia at postmillennium development goals era. | the world will enter the postmillennium development goals 2015 era. the achievements of the millennium development goals (mdgs) as a global development target need to be evaluated. a sustainable new reasonable target is important for neglected tropical diseases (ntd) elimination in indonesia. this review describes the ntd situation in indonesia and highlights problems beneath the ntd transmission. multidisciplinary approach is a promising strategy to help the marginalized people. | 2016 | 27190525 |
| entomological assessment of yellow fever-epidemic risk indices in benue state, nigeria, 2010-2011. | yellow fever (yf) is a vector-borne disease affecting humans and non-human primates in tropical areas. in the past, there have been pockets of yf outbreaks in nigeria that resulted in preventable deaths. surveillance efforts towards avoiding another outbreak have been put in place with the aim of early detection and control. however, risk indices relating to the density of immature yf-mosquito vectors are given little consideration even though it is the first step in curbing a possible outbreak. ... | 2016 | 27189925 |
| [infestation status aedes albopictus and related mosquito-borne infectious disease risk in central urban area in shanghai]. | to evaluate aedes albopictus infestation status in the central urban area of shanghai, and analyze the related epidemic risk of mosquito-borne infectious disease. | 2016 | 27188346 |
| personal protection of permethrin-treated clothing against aedes aegypti, the vector of dengue and zika virus, in the laboratory. | the dengue and zika viruses are primarily transmitted by aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. personal protection technologies such as insecticide-treated clothing could provide individual protection. here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. | 2016 | 27187593 |
| evidence for the induction of key components of the notch signaling pathway via deltamethrin and azamethiphos treatment in the sea louse caligus rogercresseyi. | the extensive use of organophosphates and pyrethroids in the aquaculture industry has negatively impacted parasite sensitivity to the delousing effects of these antiparasitics, especially among sea lice species. the notch signaling pathway is a positive regulator of abc transporter subfamily c expression and plays a key role in the generation and modulation of pesticide resistance. however, little is known about the molecular mechanisms behind pesticide resistance, partly due to the lack of geno ... | 2016 | 27187362 |
| biological screening of selected pacific northwest forest plants using the brine shrimp (artemia salina) toxicity bioassay. | the brine shrimp (artemia salina) bioassay was used to screen 211 methanol extracts from 128 species of pacific northwest plants in search of general cytotoxic activity. strong toxicity (lc50 < 100 µg/ml) was found for 17 extracts from 13 species, with highest activity observed for angelica arguta roots at <10 µg/ml. notably, four species of cedar trees and one of juniper in the family cupressaceae dominated this group with lc50 for heartwood extracts ranging from 15 to 89 µg/ml. moderate toxici ... | 2016 | 27186474 |
| an evidence-based review on medicinal plants used as insecticide and insect repellent in traditional iranian medicine. | insects can be the cause of major ecological problems; they can transmit microbes and parasites that affect humans, and damage food crops, trees, and homes. the total economic cost of insect-related damage and disease is immeasurable. in traditional iranian medicine (tim), several medicinal plants have been identified as insecticides or insect repellents, but many of them are still unknown. therefore, the aim of this study was to review the insecticidal or insect repellent activity of certain me ... | 2016 | 27186389 |
| mammalian african trypanosome vsg coat enhances tsetse's vector competence. | tsetse flies are biological vectors of african trypanosomes, the protozoan parasites responsible for causing human and animal trypanosomiases across sub-saharan africa. currently, no vaccines are available for disease prevention due to antigenic variation of the variant surface glycoproteins (vsg) that coat parasites while they reside within mammalian hosts. as a result, interference with parasite development in the tsetse vector is being explored to reduce disease transmission. a major bottlene ... | 2016 | 27185908 |
| a critical role for the drosophila dopamine d1-like receptor dop1r2 at the onset of metamorphosis. | insect metamorphosis relies on temporal and spatial cues that are precisely controlled. previous studies in drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. multiple factors exist that safeguard these genes against dysregulated expression. the list of identified negative regulators that play such a role in drosophila development continues to expand. | 2016 | 27184815 |
| the influence of larval competition on brazilian wolbachia-infected aedes aegypti mosquitoes. | with field releases starting in brazil, particular interest must be given to understanding how the endosymbiotic bacterium wolbachia pipientis affects aedes aegypti mosquitoes with a brazilian genetic background. currently, there is limited information on how the bacterium affects phenotypic traits such as larval development rate, metabolic reserves and morphometric parameters in ae. aegypti. here, we analyze for the first time, the effect of wolbachia on these key phenotypes and consider how th ... | 2016 | 27183820 |
| novel lesions of bones and joints associated with chikungunya virus infection in two mouse models of disease: new insights into disease pathogenesis. | chikungunya virus is an arbovirus spread predominantly by aedes aegypti and ae. albopictus mosquitoes, and causes debilitating arthralgia and arthritis. while these are common manifestations during acute infection and it has been suggested they can recur in patients chronically, gaps in knowledge regarding the pathogenesis still exist. two established mouse models were utilized (adult irf 3/7 -/- -/- and wild-type c57bl/6j mice) to evaluate disease manifestations in bones and joints at various t ... | 2016 | 27182740 |
| functional and immunohistochemical characterization of cceae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors aedes aegypti and ae. albopictus. | temephos is a major organophosphate (op) larvicide that has been used extensively for the control of aedes albopictus and aedes aegypti, the major vectors for viral diseases, such as dengue fever, zika and chikungunya. resistance to temephos has been recently detected and associated with the upregulation of carboxylesterases (cces) through gene amplification, in both species. here, we expressed the cceae3a genes which showed the most striking up-regulation in resistant aedes strains, using the b ... | 2016 | 27180726 |
| dsrna-mediated targeting of ribosomal transcripts rps6 and rpl26 induces long-lasting and significant reductions in fecundity of the vector aedes aegypti. | ribosomal transcripts produce critical proteins that are involved in most cellular production processes. targeting ribosomal transcripts has produced mortality in mites and ticks but the effect of ribosomal transcript knockdown has not been thoroughly examined in mosquitoes. we examine the effects of triggers targeting four ribosomal proteins (rp) transcripts. although no significant mortality was observed after dsrna microinjection and subsequent blood feeding, significant contrasts were observ ... | 2016 | 27180677 |
| gravid anopheles gambiae sensu stricto avoid ovipositing in bermuda grass hay infusion and it's volatiles in two choice egg-count bioassays. | a number of mosquito species in the culex and aedes genera prefer to lay eggs in bermuda grass (cynodon dactylon) hay infusions compared to water alone. these mosquitoes are attracted to volatile compounds from the hay infusions making the infusions effective baits in gravid traps used for monitoring vectors of arboviral and filarial pathogens. since bermuda grass is abundant and widespread, it is plausible to explore infusions made from it as a potential low cost bait for outdoor monitoring of ... | 2016 | 27177033 |
| an rna-dependent rna polymerase gene in bat genomes derived from an ancient negative-strand rna virus. | endogenous bornavirus-like l (ebll) elements are inheritable sequences derived from ancient bornavirus l genes that encode a viral rna-dependent rna polymerase (rdrp) in many eukaryotic genomes. here, we demonstrate that bats of the genus eptesicus have preserved for more than 11.8 million years an ebll element named eebll-1, which has an intact open reading frame of 1,718 codons. the eebll-1 coding sequence revealed that functional motifs essential for mononegaviral rdrp activity are well conse ... | 2016 | 27174689 |
| evolution, expression, and function of nonneuronal ligand-gated chloride channels in drosophila melanogaster. | ligand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. paradoxically, expression databases in drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, cg7589, cg6927, and cg11340, are highly expressed in nonneuronal tissues. furthermore, subunit copy number varies between insects, with some orders containing one ortholog, whereas other lineages exhibit copy numb ... | 2016 | 27172217 |
| reduced incidence of chikungunya virus infection in communities with ongoing aedes aegypti mosquito trap intervention studies - salinas and guayama, puerto rico, november 2015-february 2016. | aedes species mosquitoes transmit chikungunya virus, as well as dengue and zika viruses, and bite most often during the day.* infectious mosquito bites frequently occur in and around homes (1,2). caribbean countries first reported local transmission of chikungunya virus in december 2013, and soon after, chikungunya virus spread throughout the americas (3). puerto rico reported its first laboratory-positive chikungunya case in may 2014 (4), and subsequently identified approximately 29,000 suspect ... | 2016 | 27171600 |
| determinants of arbovirus vertical transmission in mosquitoes. | vertical transmission (vt) and horizontal transmission (ht) of pathogens refer to parental and non-parental chains of host-to-host transmission. combining ht with vt enlarges considerably the range of ecological conditions in which a pathogen can persist, but the factors governing the relative frequency of each transmission mode are poorly understood for pathogens with mixed-mode transmission. elucidating these factors is particularly important for understanding the epidemiology of arthropod-bor ... | 2016 | 27171170 |
| experimental studies of susceptibility of italian aedes albopictus to zika virus. | we report a study on vector competence of an italian population of aedes albopictus for zika virus (zikv). ae. albopictus was susceptible to zikv infection (infection rate: 10%), and the virus could disseminate and was secreted in the mosquito's saliva (dissemination rate: 29%; transmission rate: 29%) after an extrinsic incubation period of 11 days. the observed vector competence was lower than that of an ae. aegypti colony tested in parallel. | 2016 | 27171034 |
| mosquito c-type lectins maintain gut microbiome homeostasis. | the long-term evolutionary interaction between the host immune system and symbiotic bacteria determines their cooperative rather than antagonistic relationship. it is known that commensal bacteria have evolved a number of mechanisms to manipulate the mammalian host immune system and maintain homeostasis. however, the strategies employed by the microbiome to overcome host immune responses in invertebrates still remain to be understood. here, we report that the gut microbiome in mosquitoes utilize ... | 2016 | 27170846 |
| argonaute 2 suppresses japanese encephalitis virus infection in aedes aegypti. | there are three main innate immune mechanisms against viruses in mosquitoes. infection with the flavivirus dengue virus is controlled by rna interference (rnai) and the jak-stat and toll signaling pathways. this study showed that another flavivirus, japanese encephalitis virus (jev), did not invade the salivary glands of aedes aegypti and that this may be a result of the innate immune resistance to the virus. argonaute 2 (ago2) plays a critical role in the rnai pathway. to understand the mechani ... | 2017 | 27169949 |
| toxicological evaluation of essential oil from the leaves of croton tetradenius (euphorbiaceae) on aedes aegypti and mus musculus. | for control of aedes aegypti, the main vector of dengue, botanical insecticides can be a viable alternative. herein, we evaluated the chemical composition and insecticidal activity of the essential oils of the leaves of croton tetradenius on ae. aegypti larvae and adults. we also evaluated the acute toxicity in mus musculus. the essential oil chemical analysis was performed using chromatography coupled with mass spectrometry and flame ionization detection. female mice were used for assessing tox ... | 2016 | 27169864 |
| composition and genomic organization of arthropod hox clusters. | the ancestral arthropod is believed to have had a clustered arrangement of ten hox genes. within arthropods, hox gene mutations result in transformation of segment identities. despite the fact that variation in segment number/character was common in the diversification of arthropods, few examples of hox gene gains/losses have been correlated with morphological evolution. furthermore, a full appreciation of the variation in the genomic arrangement of hox genes in extant arthropods has not been re ... | 2016 | 27168931 |
| zika virus: a roar after years of whispering. | 0 | 27168917 | |
| evaluation of mosquito repellent activity of isolated oleic acid, eicosyl ester from thalictrum javanicum. | to evaluate the traditional use, the mosquito repellent property of thalictrum javanicum and to confirm the predicted larvicidal activity of the isolated compound, oleic acid, eicosyl ester from its aerial parts by pass software, the present study was carried out using 4th instar stage larvae of the mosquitoes, aedes aegypti (dengue vector) and culex quinquefasciatus (filarial vector). insecticidal susceptibility tests were conducted and the mortality rate was observed after 24 h exposure. the c ... | 0 | 27168688 |
| biotype characterization, developmental profiling, insecticide response and binding property of bemisia tabaci chemosensory proteins: role of csp in insect defense. | chemosensory proteins (csps) are believed to play a key role in the chemosensory process in insects. sequencing genomic dna and rna encoding csp1, csp2 and csp3 in the sweet potato whitefly bemisia tabaci showed strong variation between b and q biotypes. analyzing csp-rna levels showed not only biotype, but also age and developmental stage-specific expression. interestingly, applying neonicotinoid thiamethoxam insecticide using twenty-five different dose/time treatments in b and q young adults s ... | 2016 | 27167733 |
| de novo transcriptome analysis and detection of antimicrobial peptides of the american cockroach periplaneta americana (linnaeus). | cockroaches are surrogate hosts for microbes that cause many human diseases. in spite of their generally destructive nature, cockroaches have recently been found to harbor potentially beneficial and medically useful substances such as drugs and allergens. however, genomic information for the american cockroach (periplaneta americana) is currently unavailable; therefore, transcriptome and gene expression profiling is needed as an important resource to better understand the fundamental biological ... | 2016 | 27167617 |
| myosin myth4-ferm structures highlight important principles of convergent evolution. | myosins containing myth4-ferm (myosin tail homology 4-band 4.1, ezrin, radixin, moesin, or mf) domains in their tails are found in a wide range of phylogenetically divergent organisms, such as humans and the social amoeba dictyostelium (dd). interestingly, evolutionarily distant mf myosins have similar roles in the extension of actin-filled membrane protrusions such as filopodia and bind to microtubules (mt), suggesting that the core functions of these mf myosins have been highly conserved over ... | 2016 | 27166421 |
| comprehensive evaluation of candidate reference genes for qrt-pcr studies of gene expression in mustard aphid, lipaphis erysimi (kalt). | mustard aphid, also known as turnip aphid (lipaphis erysimi) is a major insect pest of rapeseed-mustard group of crops. tremendous economic significance has led to substantial basic research involving gene-expression studies in this insect species. in qrt-pcr analysis of gene-expression, normalization of data against rna variation by using appropriate reference gene is fundamental. however, appropriate reference genes are not known in case of l. erysimi. we evaluated 11 candidate reference genes ... | 2016 | 27165720 |
| an antibody against an anopheles albimanus midgut myosin reduces plasmodium berghei oocyst development. | malaria parasites are transmitted by anopheles mosquitoes. although several studies have identified mosquito midgut surface proteins that are putatively important for plasmodium ookinete invasion, only a few have characterized these protein targets and demonstrated transmission-blocking activity. molecular information about these proteins is essential for the development of transmission-blocking vaccines (tbv). the aim of the present study was to test three monoclonal antibodies (mabs), a-140, a ... | 2016 | 27165123 |
| the persistence and ecological impacts of a cyanobacterium genetically engineered to express mosquitocidal bacillus thuringiensis toxins. | the cyanobacterium anabaena pcc 7120#11 has been genetically engineered to act as a delivery vehicle for bacillus thuringiensis subspecies israelensis mosquitocidal toxins. to address ecological concerns about releasing this genetically engineered microorganism into the environment for mosquito larva control, the persistence and ecological impacts of pcc 7120#11 was evaluated using multi-species, standardized aquatic microcosms. | 2016 | 27165108 |
| physicians, primary caregivers and topical repellent: all under-utilised resources in stopping dengue virus transmission in affected households. | primary health care facilities frequently manage dengue cases on an ambulatory basis for the duration of the patient's illness. there is a great opportunity for specific messaging, aimed to reduce dengue virus (denv) transmission in and around the home, to be directly targeted toward this high-risk ambulatory patient group, as part of an integrated approach to dengue management. the extent however, to which physicians understand, and can themselves effectively communicate strategies to stop foca ... | 2016 | 27164168 |
| the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model. | zika virus (zikv) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns, have potentially been linked to this viral infection. we established a panel of in vitro assays to allow the identification of zikv inhibitors and demonstrate that the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine (7dma) efficiently inhibits replication. infection of ag129 (ifn-α/β and ifn-γ receptor knock-out) mice with zikv res ... | 2016 | 27163257 |
| high-throughput cis-regulatory element discovery in the vector mosquito aedes aegypti. | despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (cres), dna sequences that control gene expression, have been identified in mosquitoes or other non-model insects. formaldehyde-assisted isolation of regulatory elements paired with dna sequencing, faire-seq, is emerging as a powerful new high-throughput tool for global cre discovery. faire results in the preferential recovery of open chromatin dna fragments that are not bound by nucleosomes, an ev ... | 2016 | 27161480 |
| diversity, evolution and medical applications of insect antimicrobial peptides. | antimicrobial peptides (amps) are short proteins with antimicrobial activity. a large portion of known amps originate from insects, and the number and diversity of these molecules in different species varies considerably. insect amps represent a potential source of alternative antibiotics to address the limitation of current antibiotics, which has been caused by the emergence and spread of multidrug-resistant pathogens. to get more insight into amps, we investigated the diversity and evolution o ... | 2016 | 27160593 |
| zika virus - emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives - a comprehensive review. | this review converses the zika virus which has attained global concern due to its rapid pandemic potential and impact on humans. though zika virus was first isolated in 1947, till the recent large-scale outbreak which occurred in micronesia, in 2007, the virus was placed into the innocuous pathogen category. the world health organization on 1 february 2016 declared it as a 'public health emergency of international concern.' of the note, american as well as pacific island strains/isolates is rela ... | 2016 | 27158761 |
| clinical and epidemiological characterization of laboratory-confirmed autochthonous cases of zika virus disease in mexico. | since 2014, autochthonous circulation of zika virus (zikv) in the americas was detected (easter island, chile). in may 2015, brazil confirmed autochthonous --transmission and in october of that year colombia reported their first cases. now more than 52 countries have reported cases, including mexico. to deal with this contingency in mexico, several surveillance systems, in addition to systems for vector-borne diseases were strengthened with the participation of all health institutions. also, th ... | 2016 | 27158557 |
| surveillance, insecticide resistance and control of an invasive aedes aegypti (diptera: culicidae) population in california. | the invasion and subsequent establishment in california of aedes aegypti in 2013 has created new challenges for local mosquito abatement and vector control districts. studies were undertaken to identify effective and economical strategies to monitor the abundance and spread of this mosquito species as well as for its control. overall, bg sentinel (bgs) traps were found to be the most sensitive trap type to measure abundance and spread into new locations. autocidal-gravid-ovitraps (ago-b), when p ... | 2016 | 27158450 |
| yellow fever cases in asia: primed for an epidemic. | there is currently an emerging outbreak of yellow fever in angola. cases in infected travellers have been reported in a number of other african countries, as well as in china, representing the first ever documented cases of yellow fever in asia. there is a large chinese workforce in angola, many of whom may be unvaccinated, increasing the risk of ongoing importation of yellow fever into asia via busy commercial airline routes. large parts of the region are hyperendemic for the related flavivirus ... | 2016 | 27156836 |
| [zika virus infection or the future of infectious diseases]. | zika virus belongs to the flaviridae, an extended phylogenetic family containing dengue or yellow fever, viruses whose shared main vector are aedes aegypti mosquitoes. the virus originally came from central african simian reservoirs and, from there, expanded rapidly across the pacific to south america. the disease is an example of exantematic fever usually mild. mortality is very low and mainly limited to secondary guillain-barré or fetal microcephaly cases. diagnostic confirmation requires a rt ... | 2016 | 27156484 |
| wolbachia blocks currently circulating zika virus isolates in brazilian aedes aegypti mosquitoes. | the recent association of zika virus with cases of microcephaly has sparked a global health crisis and highlighted the need for mechanisms to combat the zika vector, aedes aegypti mosquitoes. wolbachia pipientis, a bacterial endosymbiont of insect, has recently garnered attention as a mechanism for arbovirus control. here we report that aedes aegypti harboring wolbachia are highly resistant to infection with two currently circulating zika virus isolates from the recent brazilian epidemic. wolbac ... | 2016 | 27156023 |
| disease vectors in the era of next generation sequencing. | almost 20 % of all infectious human diseases are vector borne and, together, are responsible for over one million deaths per annum. over the past decade, the decreasing costs of massively parallel sequencing technologies have facilitated the agnostic interrogation of insect vector genomes, giving medical entomologists access to an ever-expanding volume of high-quality genomic and transcriptomic data. in this review, we highlight how genomics resources have provided new insights into the physiolo ... | 2016 | 27154554 |