Publications

valproate-associated hepatotoxicity and its biochemical mechanisms.	intake of the anticonvulsant drug valproic acid, or its sodium salt, has been associated with occasional instances of severe and sometimes fatal hepatotoxicity. probably at least 80 cases have occurred worldwide. the syndrome affects perhaps 1 in 10,000 persons taking the drug, and usually develops in the early weeks or months of therapy. most instances have involved children, usually those receiving more than 1 anticonvulsant. multiple cases have occurred in 2 families. the typical presentation ...	2011	3131628
adult epiglottitis due to vibrio vulnificus.		1988	3130933
[enterostoma therapy--a pilot course in the essen education center of the german nursing association].		2011	3127632
decreased locomotor activity produced by repeated, but not single, administration of murine-recombinant interferon-gamma in mice.	a single treatment with murine-recombinant interferon-gamma (murifn-gamma; 30 micrograms/mouse), whether evaluated immediately after, or four hrs after, intraperitoneal injection, does not alter open field activity levels. on the other hand, repeated murifn-gamma administration (30 micrograms/mouse/day for 5 days) results in decreased spontaneous locomotor activity and an increase in body weight.	1988	3126371
purification and partial characterization of serum monocytotropic factor, a platelet-derived cyclooxygenase-inducing polypeptide.	it has previously been shown that a heat- and acid-stable component of human and animal sera was capable of stimulating prostanoid biosynthesis in human blood monocytes, very probably by a mechanism involving cyclooxygenase induction. many physico-chemical characteristics of this factor are similar to those of identified platelet factors. here we show that human platelets are a rich source of this factor (serum monocytotropic factor) and that results from experiments using arachidonic acid or th ...	1988	3124880
covalent coupling of 4-thiouridine in the initiator methionine trna to specific lysine residues in escherichia coli methionyl-trna synthetase.	a new method has been developed to couple a lysine-reactive cross-linker to the 4-thiouridine residue at position 8 in the primary structure of the escherichia coli initiator methionine trna (trnafmet). incubation of the affinity-labeling trnafmet derivative with e. coli methionyl-trna synthetase (metrs) yielded a covalent complex of the protein and nucleic acid and resulted in loss of amino acid acceptor activity of the enzyme. a stoichiometric relationship (1:1) was observed between the amount ...	1987	3122828
[primary leiomyosarcoma of the pulmonary artery. apropos of a case].	a case of leiomyosarcoma of the pulmonary artery in a 64-year old man without previous cardiovascular disease is reported. the clinical picture, which comprised episodes of paroxysmal dyspnoea associated with acute cor pulmonale, suggested pulmonary embolism. radioisotope perfusion study and pulmonary angiography seemed to confirm this diagnosis, but no improvement was obtained with a prolonged thrombolytic treatment. the presence of a median mass at ct led to exploratory thoracotomy and to the ...	1987	3122693
deficiency of eosinophil peroxidase detected by automated cytochemistry.		2011	3122494
purification of an octamer sequence (atgcaaat)-binding protein from human b cells.	the highly conserved octamer sequence atgcaaat or its inverse complement found in all human and murine immunoglobulin gene promoters has been demonstrated to be necessary in the lymphoid-specific transcription by deletion analysis. trans-acting factors that interact with the octamer motif are thought to be involved in this tissue-specific expression. using a gel mobility shift assay, we have identified both lymphoid-specific and ubiquitous nuclear factors that interact with a human gamma 1 heavy ...	1987	3122182
the place of exercise in the long-term treatment of hypertension.	the antihypertensive effects of exercise have been examined in 2 randomized studies of multiple levels of activity. in 12 normal subjects, 1 month's exercise 3 times weekly lowered blood pressure (bp) and vascular resistance. there was only a slightly greater effect after 7 times/week exercise. in most subjects there was a marked reduction in noradrenaline spillover rate, a measure of sympathetic activity. exercise also improved glucose utilization and lowered plasma cholesterol. thirteen previo ...	2011	3122065
[planned introduction and execution of the nursing process in practice. a challenge to inservice training].		2011	3119931
interleukin-1 stimulation in the esrd patient: potential long-term consequences.		2011	3118543
inhibitory effect of capsular antigen of vibrio vulnificus on bactericidal activity of human serum.	opaque (op) and translucent (tr) colonial variants were isolated from vibrio vulnificus strains. op-type variants were more resistant than the isogenic tr-type variants, but the survival rate of the op-type variants varied with the strains. antisera were prepared by immunizing rabbit with whole cells of op and tr variants of some strains, in which the difference of the sensitivity between op and tr cells was remarkable. then agglutination tests with their living and heat-killed cells were carrie ...	1987	3116370
hodgkin's disease in the spleen. a morphological study of 140 biopsy cases.	140 spleens involved by untreated hodgkin's disease were studied utilizing conventional histological methods. regardless of the subtype of hodgkin's disease, infiltrates of neoplastic cells were present either in the periarteriolar lymphoid sheath, the marginal zone or in both locations. initially, infiltrates were confined to the splenic white pulp, later larger nodular foci of hodgkin's disease developed by coalescence of several infiltrates. neoplastic cells in hodgkin's disease may reach the ...	2010	3114946
partial lipodystrophy: report of a case.		2011	3114415
oesophageal pain exacerbated by propranolol.		2011	3113570
comparison of glycosidase levels in bovine seminal plasma.	seven glycosidases (beta-n-acetylglucosaminidase, alpha-fucosidase, beta-galactosidase, acid alpha-glucosidase, beta-glucuronidase, acid and neutral alpha-mannosidase) were analysed in seminal plasma from the first and second successive ejaculates in normal ayrshire bulls. in comparison to our previous data the results indicate that beta-n-acetylglucosaminidase, beta-galactosidase and beta-glucuronidase are derived mainly from epididymal secretions, while alpha-fucosidase and particularly neutra ...	1987	3112030
stimulation by hyphopichia burtonii and bacillus amyloliquefaciens of aflatoxin production by aspergillus flavus in irradiated maize and rice grains.	aspergillus flavus was grown on maize and rice extract agars and on irradiated viable cracked maize and rice grains, either in pure culture or in dual culture with wild strains of either hyphopichia burtonii or bacillus amyloliquefaciens. aflatoxin production by a. flavus and its growth and interactions with the other microorganisms were studied at three water activities (aw) (0.98, 0.95, and 0.90) and two temperatures (25 and 16 degrees c). both h. burtonii and b. amyloliquefaciens markedly sti ...	1987	3111368
biosynthesis and processing of platelet gpiib-iiia in human megakaryocytes.	platelet membrane glycoprotein iib-iiia forms a calcium-dependent heterodimer and constitutes the fibrinogen receptor on stimulated platelets. gpiib is a two-chain protein containing disulfide-linked alpha and beta subunits. gpiiia is a single chain protein. these proteins are synthesized in the bone marrow by megakaryocytes, but the study of their synthesis has been hampered by the difficulty in obtaining enriched population of megakaryocytes in large numbers. to examine the biosynthesis and pr ...	1987	3108266
use of locally injected anti-t monoclonal antibodies in the treatment of acute corneal graft rejection.		2010	3108097
protamine sulfate-induced enzyme secretion from rabbit neutrophils.	protamine sulfate induces enzyme secretion from rabbit neutrophils. enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. as compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by exocytosis is a relatively slow process and is not accompanied by a marked activation of the metabolic burst. for optimal exocytosis, extracellular ca2+ is required, but there is stil ...	1986	3098680
[a saved case of vibrio vulnificus infection with shock, dic and necrotizing fasciitis].		1986	3097209
progestins and oral contraceptive-induced lipoprotein changes: a prospective study.	in order to determine the effects on plasma lipoproteins of oral contraceptives containing progestins with varying androgenic potency, 136 healthy women were randomized into 3 groups and followed prospectively for one year while receiving either 50 mcg ethinyl estradiol and 1.0 mg ethynodiol diacetate (eed), 50 mcg ethinyl estradiol and 1.0 mg norethindrone acetate (ena), or 50 mcg ethinyl estradiol and 0.5 mg d-1 norgestrel (eng). comparison was made to a self-selected group of 50 women using a ...	2011	3096633
annual summary 1984. reported morbidity and mortality in the united states.		2011	3092006
nasopharyngeal carriage of neisseria meningitidis in the contacts of index cases of meningococcal meningitis.		1986	3091676
limitations in the use of 14c-glycocholate breath and stool bile acid determinations in patients with chronic diarrhea.	analysis of a modified 14c-glycocholate breath test on 165 consecutive in-patients being investigated for chronic diarrhea showed that the measurement of 14co2 between 3 and 6 h after oral dosing of 5 microci of 14c-glycocholic acid was of only limited use to distinguish between patients with crohn's disease (cd), idiopathic bile salt wastage (ibw), or ileal resection (ir) from those with the irritable bowel syndrome (ibs). continuing 14co2 collections for up to 24 h was of little more help in e ...	2011	3090133
additional eye findings in a girl with the velo-cardio-facial syndrome.		2010	3089013
evidence that some membrane ligands modulate the plasmalemma fluidity of endothelial cells in culture.	the effect of some membrane ligands on the plasmalemmal fluidity of endothelial cells from bovine aorta in culture was investigated. the ligands used were: cationic ferritin (pi 8.5), soybean agglutinin, concanavalin a, wheat germ agglutinin, as well as glutaraldehyde at different concentrations. the fluidity probe employed was 1,6-diphenyl-1, 3, 5-hexatriene (dph) and the parameter determined to quantify the fluidity was fluorescence steady-state anisotropy. the optimum time interval required b ...	1986	3088620
effect of nifedipine on cerebral high-energy phosphates after cardiac arrest and resuscitation in the rat.	we studied the effect of nifedipine, a calcium entry blocker, on the recovery of cerebral adenosine triphosphate (atp), creatine phosphate (cp), and lactate levels following resuscitation from cardiac arrest. using the cardiac arrest and resuscitation model of de garavilla, babbs, and tacker with an arrest time of eight minutes, 76% of the animals arrested were resuscitated with an average intermittent abdominal compression-cpr time of 3.3 minutes. rats were assigned randomly to the following gr ...	1986	3085559
some properties of lipoxygenase activities in cytosol and microsomal fractions of mouse epidermal homogenate.	lipoxygenase activity in microsomal fraction of mouse epidermal homogenate was characterized in comparison with cytosol lipoxygenase activity. the major activity was identified as 12-lipoxygenase in microsomal fraction as well as in cytosol fraction by the analyses with high-performance liquid chromatography and gas chromatography-mass spectrometry. apparent km values of cytosol and microsomal 12-lipoxygenase for arachidonic acid were 5.0 microm and 6.2 microm respectively. apparent vmax values ...	1986	3085110
some properties of lipoxygenase activities in cytosol and microsomal fractions of mouse epidermal homogenate.	lipoxygenase activity in microsomal fraction of mouse epidermal homogenate was characterized in comparison with cytosol lipoxygenase activity. the major activity was identified as 12-lipoxygenase in microsomal fraction as well as in cytosol fraction by the analyses with high-performance liquid chromatography and gas chromatography-mass spectrometry. apparent km values of cytosol and microsomal 12-lipoxygenase for arachidonic acid were 5.0 microm and 6.2 microm respectively. apparent vmax values ...	1986	3085110
identification of n epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.	the chemistry of maillard or browning reactions of glycated proteins was studied using the model compound, n alpha-formyl-n epsilon-fructoselysine (ffl), an analog of glycated lysine residues in protein. incubation of ffl (15 mm) at physiological ph and temperature in 0.2 m phosphate buffer resulted in formation of n epsilon-carboxymethyllysine (cml) in about 40% yield after 15 days. cml was formed by oxidative cleavage of ffl between c-2 and c-3 of the carbohydrate chain and erythronic acid (ea ...	1986	3082871
second-generation cephalosporins.		1986	3081544
conversion of serine to glycerate in intact spinach leaf peroxisomes: role of malate dehydrogenase.	in photorespiration, leaf peroxisomes convert serine to glycerate via serine-glyoxylate aminotransferase and nadh-hydroxypyruvate reductase. we isolated intact spinach leaf peroxisomes in 0.25 m sucrose, and characterized their enzymatic conversion of serine to glycerate using physiological concentrations of substrates and coenzymes. in the presence of glycolate (glyoxylate), and nadh and nad alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced ...	2011	3080957
promoter selectivity of prokaryotic rna polymerases.		2011	3076288
promoter selectivity of prokaryotic rna polymerases.		2011	3076288
parasitic diarrhea.	this article reviews the biology, epidemiology, and clinical management of amebiasis, giardiasis, and cryptosporidiosis as well as the less common intestinal protozoa, dientamoeba fragilis, isospora belli, balantidium coli, and blastocystis hominis.	1988	3074123
parasitic diarrhea.	this article reviews the biology, epidemiology, and clinical management of amebiasis, giardiasis, and cryptosporidiosis as well as the less common intestinal protozoa, dientamoeba fragilis, isospora belli, balantidium coli, and blastocystis hominis.	1988	3074123
subcutaneous bronchogenic cysts.	recent experience with a bronchogenic cyst occurring in a subcutaneous suprasternal location presents an additional entity to be considered in the differential diagnosis of head and neck lesions, and correlates with the embryology of the developing tracheobronchial tree and sternum. a review of subcutaneous bronchogenic cysts shows 41 cases have been described in the english literature. most were noted in the suprasternal location; all but one were first noted in infancy or childhood. there is a ...	2011	3072402
[pharmacokinetic and toxicologic aspects of stress].		2011	3069119
role of the protease in the permeability enhancement by vibrio vulnificus.	the protease produced by vibrio vulnificus enhances vascular permeability through histamine release from mast cells and activation of the plasma kallikrein-kinin system which generates bradykinin when injected into the dorsal skin. v. vulnificus living cells also enhanced vascular permeability within a few hours after the injection into the dorsal skin. the permeability-enhancing activity of living cells was greatly reduced by addition of soybean trypsin inhibitor, a specific inhibitor for plasm ...	1988	3068493
a case of vibrio vulnificus infection.	vibrio vulnificus, a recently described strain of the halophilic vibrio species, was isolated from the blood of a 73-year-old man, who developed rapidly progressive wound infection and fatal septicemia. twenty-one patients with vibrio vulnificus infection have been reported in the japanese literature. vibrio vulnificus most frequently causes primary septicemia and necrotising cellulitis after the eating of raw fish or shellfish or after exposure to seawater. the infection is characterized by its ...	1988	3068394
[academic dissertations of military pharmacists on the history of pharmacy].		2011	3067684
captopril--a new approach for treatment of male subfertility?		2011	3067628
what schedule-induced polydipsia can tell us about alcoholism.	an animal model of chronic and excessive voluntary (unforced) alcohol ingestion is presented in which, by drinking, animals produce repeated, substantial elevations in blood ethanol concentration and develop physical dependence. the overindulgence is elective in that ethanol is chosen in preference to certain other fluid-ingestive alternatives. beside the usual demonstrations of acutely compromised motor performance, tolerance development, cross-tolerance, etc., the model demonstrates that the c ...	1988	3067598
what schedule-induced polydipsia can tell us about alcoholism.	an animal model of chronic and excessive voluntary (unforced) alcohol ingestion is presented in which, by drinking, animals produce repeated, substantial elevations in blood ethanol concentration and develop physical dependence. the overindulgence is elective in that ethanol is chosen in preference to certain other fluid-ingestive alternatives. beside the usual demonstrations of acutely compromised motor performance, tolerance development, cross-tolerance, etc., the model demonstrates that the c ...	1988	3067598
[use of photosensitizing preparations in the treatment of cancer of the orl organs].		2011	3067440
emphasis on preventive perinatology: a suitable alternative for developing countries.	the potential efficacy of preventive interventions in latin america to reduce perinatal morbidity and mortality is reviewed. the most important perinatal risk factors associated with pregnancy and delivery are young age of the mother, low socioeconomic status, low education, malnutrition, lack of prenatal care, pregnancy-induced-hypertension, perinatal infections, alcohol, smoking, and iatrogenic causes. adequate data are lacking to determine the magnitude of these factors in latin america. iatr ...	2011	3065947
vitamin e deficiency and neurologic disease.	during the recent resurgence of interest in the clinical uses of vitamin e, one of the major foci of attention has been the neurologic role of vitamin e in humans. studies in patients with secondary vitamin e deficiency, caused by fat malabsorption disorders and total parenteral nutrition lacking an adequate supply of vitamin e, have elucidated a clinical disorder and histologic lesions of the nervous system and muscle that closely resemble those of experimental vitamin-e-deficient animal models ...	1988	3060170
morbidity and mortality of carotid endarterectomy under local anesthesia: a retrospective study.	it has been shown that carotid endarterectomy reduces the incidence of stroke in patients with symptomatic extracranial occlusive vascular disease in the absence of major perioperative complications such as stroke or death. we present a retrospective study of 106 carotid endarterectomies performed under local anesthesia in 100 patients in whom transient ischemic attack (tia) or minor stroke had occurred. nonfatal stroke occurred in 2%, and tia occurred in 1%. there was no perioperative mortality ...	2011	3059211
high-molecular-weight neutral proteinase of rat ascites hepatoma cells and their collagenolytic activity.	a high-molecular-weight proteinase in rat ascites hepatoma ah109a cells was purified to apparent homogeneity by conventional chromatographic techniques. the purified proteinase degraded over the broad ph range, 7.0-9.0, not only denatured hemoglobin but also type i and iv collagen in the absence of calcium. its activity was maximum at ph 8.0, heat-labile and affected by thiol reagents. serine proteinase inhibitors such as diisopropyl fluorophosphate, soybean trypsin inhibitor, leupeptin, and ant ...	1988	3058624
probable detection of kil peptide derived from colicin e1 plasmid in the envelope fraction of escherichia coli hb101 carrying peap31.	escherichia coli carrying plasmid peap31 produces extracellularly alkalophilic bacillus penicillinase encoded on the plasmid. the extracellular production has been suggested to be caused by activation of dormant colicin e1 kil gene. two peptides that could be respectively precursor and mature products of colicin e1 kil gene were detected on an sds/polyacrylamide gel. one of the peptides (mr 4800), which was probably a precursor peptide, was detected in the inner-membrane fraction from the organi ...	1988	3058121
probable detection of kil peptide derived from colicin e1 plasmid in the envelope fraction of escherichia coli hb101 carrying peap31.	escherichia coli carrying plasmid peap31 produces extracellularly alkalophilic bacillus penicillinase encoded on the plasmid. the extracellular production has been suggested to be caused by activation of dormant colicin e1 kil gene. two peptides that could be respectively precursor and mature products of colicin e1 kil gene were detected on an sds/polyacrylamide gel. one of the peptides (mr 4800), which was probably a precursor peptide, was detected in the inner-membrane fraction from the organi ...	1988	3058121
a mutant human proinsulin is secreted from islets of langerhans in increased amounts via an unregulated pathway.	a coding mutation in the human insulin gene (his-b10----asp) is associated with familial hyperproinsulinemia. to model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of langerhans. strain 24-6 mice, containing about 100 copies of the mutant gene, were normoglycemic but had marked increases of serum human proinsulin immunoreactive components. biosynthetic studies on isolated islets revealed that approximately 65% of the proinsulin ...	1988	3057496
a mutant human proinsulin is secreted from islets of langerhans in increased amounts via an unregulated pathway.	a coding mutation in the human insulin gene (his-b10----asp) is associated with familial hyperproinsulinemia. to model this syndrome, we have produced transgenic mice that express high levels of the mutant prohormone in their islets of langerhans. strain 24-6 mice, containing about 100 copies of the mutant gene, were normoglycemic but had marked increases of serum human proinsulin immunoreactive components. biosynthetic studies on isolated islets revealed that approximately 65% of the proinsulin ...	1988	3057496
some extra-articular manifestations of arthritis and complications of therapy. a pictorial essay.	more than 100 years ago lasegue wrote, "rheumatic fever licks at the joint but bites at the heart." this truth may be expanded to include nearly every joint ailment on one hand, and nearly every organ system on the other hand. in connective tissue disorders, bleeding diasthesias and metabolic and endocrine disorders, the joint manifestations are only one part of the total picture. this article shows a few examples of cardiopulmonary, gastrointestinal, and other manifestations. a few examples of ...	2011	3051097
racism, the national health service, and the health of black people.	racism has been and is central to an understanding of the health of black people in britain. black people have played and are playing a central role in the national health service (nhs). their role is, however, shaped by racism. their experiences as consumers of the nhs are also shaped by racism--in terms of their treatment for both physical and mental health problems. in addition, their specific health problems such as sickle cell anemia have not received the attention they deserve. the nhs has ...	2011	3049409
bimaxillary proclination in patients of afro-caribbean origin.	the facial morphology of the afro-caribbean negro is reviewed and the aims of treatment for bimaxillary proclination and its subsequent stability are discussed. treatment approaches to various clinical situations are described, together with their known limitations.	2011	3048380
[a multi-factorial approach in the vital prognosis of spontaneous intracerebral hematoma].	the prognostic assessment of a patient with intra-cerebral hemorrhage (ih) requires simultaneous appraisal of several parameters. we have attempted this with a multivariate method: discriminant analysis. we studied retrospectively 142 patients with non-operated ih, not due to vascular malformation, distributed two months after the initial event in two groups: 92 living patients and 50 dead. discriminant analysis of 21 parameters from the initial examination and ct scan, selected five factors whi ...	2010	3047834
the history of the use of vacuum extraction.		2010	3047531
[x-ray computed tomography in venous pathology].	after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed.	2011	3043474
pemphigoid-like bullous eruption related to ibuprofen.	we report two patients who had a bullous eruption limited to the lower extremities when first seen by us. clinically the eruption resembled limited bullous pemphigoid. in both patients the onset of the eruption was associated with ibuprofen therapy, and lesions promptly resolved after discontinuing the ibuprofen. this type of presentation has not been reported previously as an adverse effect of ibuprofen. bullous reactions to nonsteroidal anti-inflammatory agents are briefly reviewed.	2011	3042819
examination of cardiac alpha-adrenoceptors from pharmacological responses and radioligand binding. comparison of rat and guinea pig tissues.	the object of this study was to determine suitable experimental conditions for the pharmacological evaluation of cardiac alpha-adrenoceptors. atrial and ventricular preparations of the guinea pig and rat were employed, and the alpha-adrenoceptor responsiveness was compared with the binding of the alpha-adrenoceptor radioligand [3h]prazosin in membranes prepared from these cardiac regions. the experimental variables examined were the pacing frequency, bath temperature, choice of agonist, and card ...	1987	3041119
identification of free radicals in myocardial ischemia/reperfusion by spin trapping with nitrone dmpo.	the spin trapping esr technique was applied to investigate oxygen-derived radicals in ischemic and post-ischemic rat hearts. using 5,5'-dimethyl-l-pyrroline-n-oxide, carbon-centered radicals were identified during ischemia and oxy-radical adducts (superoxide anion radical, o.-2 and hydroxyl radicals, .oh) in post-ischemic rat heart. the formation of these spin adducts was inhibited by superoxide dismutase, suggesting that superoxide plays a role in the adducts' formation. the results demonstrate ...	1987	3040465
characterization of two types of histone h2b genes from macronuclei of tetrahymena thermophila.	two histone h2b gene clones were isolated from macronuclei of tetrahymena thermophila. nucleotide sequences of the two clones were highly homologous within the coding region but not in the noncoding region. comparison of the deduced amino acid sequences between the two clones showed three differences in a total of 121 amino acids. each of the two clones contained a taa triplet within the coding region, which appeared to code for a glutamine residue. to demonstrate the existence of histone mrna c ...	2010	3039463
cyclophosphamide in chronic progressive multiple sclerosis.		2010	3037447
cyclophosphamide in chronic progressive multiple sclerosis.		2010	3037447
radiation-induced dna damage and its repair.	application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ...	1987	3034813
radiation-induced dna damage and its repair.	application of modern methods of organic chemistry and recombinant dna technologies has provided new insights in the field of dna radiation damage and its repair. an overview of the chemical nature of the lesions inflicted on dna by ionizing radiation is presented. the structures of 29 different dna modified base or sugar residues are shown in comprehensive formation schemes. a fraction of radiation-induced modified bases is spontaneously released from the dna chain during irradiation. another p ...	1987	3034813
calmodulin-mediated cadmium inhibition of phosphodiesterase activity, in vitro.	ion-stripped bovine brain calmodulin (cam) binds 4 moles cd2+ as well as 4 moles ca2+ per mole protein, with similar affinity; in the presence of 1 mm mg2+ the molar binding ratio of cam for ca2+ decreased to 3, the apparent k0.5 for ca2+ nearly doubled, but the binding characteristics of cam for cd2+ were not changed. saturating concentrations ca2+ did not affect the molar binding ratio of cam for cd2+, but increased the apparent k0.5 for cd2+; vice versa, saturating concentrations cd2+ decreas ...	1987	3034196
maturation antigen of the mouse sperm flagellum: ii. origin from holocrine cells of the distal caput epididymis.	during epididymal transit, the mouse sperm flagellum acquires a surface glycoprotein (sma4) from epididymal fluid that functions as a sperm antiagglutinin. to determine the origin of this molecule, testes and epididymides of male mice were sectioned for light microscopy and stained with wheat germ agglutinin (wga)-peroxidase, a probe that has been used previously to examine the biology of sma4. wga reactivity was localized to the cytoplasm in a small population of cells in the distal caput epidi ...	1987	3034104
effects of inhibitors of the cytoplasmic structures and functions on the early phase of infection of cultured cells with simian virus 40.	to obtain information about cytoplasmic structures and functions involving the entry of simian virus 40 virions into cells, we examined whether the inhibitors that affect the functions and/or structure of lysosomes, cell membrane, and cytoskeletons inhibit expression of nuclear t antigen in the sv40-inoculated rat 3y1 and monkey cv-1 cells. chloroquine, methylamine, and butylamine did not inhibit t-antigen expression, suggesting that lysosomal acidification is not required for establishment of i ...	1987	3033894
role of postnatal gonadal function in the determination of thyrotropin (tsh) releasing hormone-induced tsh response in adult male and female rats.	permanent effects of postnatal gonadal function on the hypothalamo-pituitary-thyroid axis were examined in male and female rats of the wistar-imamichi strain. animals were used at the age of about 10 weeks. neonatally castrated (nc) males showed a significantly higher plasma tsh response to trh (10 micrograms/kg bw, ip) than males castrated at 1, 2, 3, 4, or 6 weeks of age. the tsh response in intact males was similar to that seen in nc males. neonatal androgenization of nc males with 100 microg ...	1987	3032567
membrane phospholipids alter nutrient transport and drug toxicity in tumorigenic fibroblasts.	the phospholipid polar head group composition of lm cell plasma membranes was nutritionally altered by choline analogue supplementation. phosphatidylcholine (pc), normally 60% of total phospholipid, was depleted by 60 to 90% in membranes from cells cultured with n, n'-dimethylethanolamine (dme), n-monomethylethanolamine (me), and ethanolamine (e). enrichment of lm cell membranes with choline analogues, such as dme-, me-, and e-containing phospholipids, decreased the transport of [3h]thymidine, [ ...	2011	3032553
the chicken carbonic anhydrase ii gene: evidence for a recent shift in intron position.	the complete nucleotide sequence of the coding region of the chicken carbonic anhydrase ii (ca ii) gene has been determined from clones isolated from a chicken genomic library. the sequence of a nearly full length chicken ca ii cdna clone has also been obtained. the gene is approximately 17 kilobase pairs (kb) in size and codes for a protein that is comprised of 259 amino acid residues. the 5' flanking region contains consensus sequences commonly associated with eucaryotic genes transcribed by r ...	1987	3029691
[histological confirmation of monostotic paget's disease in the sacrum by ct-guided bone puncture biopsy].		2011	3024265
identification and characterization of mg2+-dependent phosphotyrosyl protein phosphatase from rat liver cytosol.	although highly purified preparations of mg2+-dependent phosphoseryl protein phosphatase (also designated phosphatase ia or phosphatase 2c) dephosphorylated phosphotyrosyl histone, the activity has been resolved from phosphatase ia by polyacrylamide gel electrophoresis at ph 9.5. this novel phosphotyrosyl-specific protein phosphatase absolutely requires mg2+ or mn2+ for activity, is inhibited by zn2+, vanadate and fluoride, and has an optimal ph of 9.0 and mr = 50,000. certain properties of this ...	1986	3022716
thymidine kinase with altered substrate specificity of acyclovir resistant varicella-zoster virus.	the acyclovir resistant mutant of varicella-zoster virus acv-r (a 8) induced the same level of thymidine kinase activity in infected cells as the parent kawaguchi strain. however, it induced less deoxycytidine kinase activity and did not induce phosphorylating activity for the nucleotide analogue, 9-(2 hydroxy-ethoxymethyl)-guanine-(acyclovir). another acyclovir resistant mutant, acv-r (a 4), which is cross-resistant to phosphonoacetate and is thought to be a viral dna polymerase mutant, induced ...	1986	3022711
subtypes and functions of alpha-adrenoceptors.		1986	3020944
[structure and functions of cloned adenovirus dna].		1986	3020801
exposure of sheep to natural aerosols of foot-and-mouth disease virus.	sheep taken individually and allowed to inhale air being drawn along a duct from a cabinet containing pigs acutely infected with foot-and-mouth disease virus for 10 or 15 minute periods were infected by doses as low as 10 tcid50 of virus. the most consistent and reliable indicators of infection were viraemia and seroconversion. the mean times from exposure to onset of viraemia, pyrexia and the appearance of vesicular lesions were 2.5, 3.8 and 4.7 days, respectively. neither the time from exposur ...	1986	3020658
evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.	two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ...	1986	3020551
evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.	two cdna clones were isolated by immunoscreening a human hepatoma cdna library with an antiserum that bound specifically to a human soluble beta-galactoside-binding lectin with mr of approximately 14,000. the deduced amino acid sequences of the inserts of these two clones show considerable homology with each other, the sequence of chicken skin beta-galactoside-binding lectin, and eight peptides derived from purified human lung lectin of mr approximately 14,000. however, the sequence differences ...	1986	3020551
production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.	the migration and proliferation of smooth muscle cells (smcs) within the intima of arteries following mechanical injury is thought to be initiated by vessel wall injury and release of growth factors, in particular the platelet-derived growth factor (pdgf). however, the mechanism by which smc proliferation is regulated after platelet interaction with the vessel wall has ceased is unknown. here we show that smcs derived from the intima of injured rat arteries (intimal smcs) are phenotypically dist ...	1986	3020543
production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.	the migration and proliferation of smooth muscle cells (smcs) within the intima of arteries following mechanical injury is thought to be initiated by vessel wall injury and release of growth factors, in particular the platelet-derived growth factor (pdgf). however, the mechanism by which smc proliferation is regulated after platelet interaction with the vessel wall has ceased is unknown. here we show that smcs derived from the intima of injured rat arteries (intimal smcs) are phenotypically dist ...	1986	3020543
[kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis].		2010	3020528
[kinin aminopeptidase in lung tissue and activity of kininase ii in the serum of patients with silicosis].		2010	3020528
mapping of the class ii region of the human major histocompatibility complex by pulsed-field gel electrophoresis.	the class ii region of the human major histocompatibility complex (mhc) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (mr) 34,000 (34 k) and a beta-chain of mr = 28k. the products of the class ii region have been characterized by the mixed lymphocyte reaction, serology, primed lymphocyte typing and dna cloning. dr, dq and dp, three subregions contai ...	1986	3020430
mapping of the class ii region of the human major histocompatibility complex by pulsed-field gel electrophoresis.	the class ii region of the human major histocompatibility complex (mhc) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (mr) 34,000 (34 k) and a beta-chain of mr = 28k. the products of the class ii region have been characterized by the mixed lymphocyte reaction, serology, primed lymphocyte typing and dna cloning. dr, dq and dp, three subregions contai ...	1986	3020430
carbachol- and norepinephrine-stimulated phosphoinositide metabolism in rat brain: effect of chronic cholinesterase inhibition.	activation of cholinergic muscarinic receptors leads to several biochemical events including an increased turnover of phosphoinositides. in this study we have investigated whether repeated administration of the organophosphorus insecticide disulfoton, known to cause the development of tolerance to this compound, would affect phosphoinositide metabolism in rat brain. basal and carbachol-stimulated phosphoinositide metabolism were measured in cerebral cortex slices, by measuring the accumulation o ...	1986	3020234
carbachol- and norepinephrine-stimulated phosphoinositide metabolism in rat brain: effect of chronic cholinesterase inhibition.	activation of cholinergic muscarinic receptors leads to several biochemical events including an increased turnover of phosphoinositides. in this study we have investigated whether repeated administration of the organophosphorus insecticide disulfoton, known to cause the development of tolerance to this compound, would affect phosphoinositide metabolism in rat brain. basal and carbachol-stimulated phosphoinositide metabolism were measured in cerebral cortex slices, by measuring the accumulation o ...	1986	3020234
susceptibility to varicella-zoster virus among adults at high risk for exposure.	the adult health care provider who is susceptible to varicella zoster virus (vzv) represents a risk to her or himself and to patients. nineteen percent of employees at this children's hospital had no or uncertain prior experience with vzv, and of these, 28% were found to be vzv susceptible, representing 5% of the total population of 2,730 hospital employees. during the 12 months of study, six of the potential 135 to 137 vzv-susceptible individuals acquired varicella. vzv-susceptible health care ...	1986	3019915
susceptibility to varicella-zoster virus among adults at high risk for exposure.	the adult health care provider who is susceptible to varicella zoster virus (vzv) represents a risk to her or himself and to patients. nineteen percent of employees at this children's hospital had no or uncertain prior experience with vzv, and of these, 28% were found to be vzv susceptible, representing 5% of the total population of 2,730 hospital employees. during the 12 months of study, six of the potential 135 to 137 vzv-susceptible individuals acquired varicella. vzv-susceptible health care ...	1986	3019915
the adenosine triphosphate-pyrophosphate isotopic exchange reaction: a tool for determination of tryptophan.	quantitative determination of tryptophan at the picomole level is described, using the atp-[32p]ppi isotopic exchange reaction catalyzed by tryptophanyl-trna synthetase. sensitivity limits of 500 fmol were obtained. the presence of other amino acids at a 1000-fold excess over tryptophan did not interfere significantly with the quantitative determination of tryptophan. the specificity of the reaction was checked using five tryptophan analogs. these analogs did not prevent the determination of try ...	2010	3014918
extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source.	extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ...	2010	3012846
extragonadal retroperitoneal germ cell tumors without apparent testicular involvement. a search for the source.	extratesticular germ cell neoplasms without apparent testicular primary tumors are rare. the origin of these neoplasms has been debated in the literature for decades. with the advent of effective chemotherapy for extratesticular germ cell neoplasms, the origin of these tumors becomes more than academic. we report on 3 cases of retroperitoneal germ cell neoplasms with microscopic intratesticular primary tumors. all patients with extragonadal germinal cell tumors of the testes should undergo thoro ...	2010	3012846
the cellular immune response in thermal injured patients.		2010	3008532
[unusual computed tomographic findings following shunting of hydrocephalus internus permagnus].		2010	3008264
dimethylthiourea consumption reflects h2o2 concentrations and severity of acute lung injury.	even though dimethylthiourea (dmtu) effectively scavenges o2 metabolites in vitro, it is often unclear if scavenging of o2 metabolites is the mechanism by which dmtu decreases tissue injury in biological models. since dmtu not only scavenges o2 metabolites but is also consumed in a dose-response manner following reaction with hydrogen peroxide (h2o2) in vitro, we wondered whether dmtu would also be consumed by o2 metabolites in biological systems and if dmtu consumption would then reflect o2 met ...	1985	3001019
effect of pyrimidinone treatment on lethal and immunosuppressive murine cytomegalovirus infection.	the 2-amino-5-halo-pyrimidinones, which are potent interferon inducers and antiviral agents, were found to be protective against lethal cytomegalovirus (cmv) challenge in weanling or neonatal mice when administered before virus challenge. this protection was dependent upon the dosage of pyrimidinone administered. weanling mice infected with a sublethal challenge of cmv exhibited moderate to severe immunosuppression as measured by reduced splenic cell blastogenic responses in vitro to the mitogen ...	1985	3000290