Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| hypophysectomy of the fetal lamb leads to a fall in the plasma concentration of insulin-like growth factor i (igf-i), but not igf-ii. | the role of the pituitary gland in the regulation of the plasma concentrations of insulin-like growth factors (igfs) in the late gestation sheep fetus has been examined. singleton sheep fetuses were either hypophysectomized or sham-operated between days 110-120 of gestation. blood samples were then collected via carotid cannulae at least three times weekly for the remainder of gestation. in some hypophysectomized fetuses t4 was administered (100 g/day) to overcome the hypothyroidism caused by hy ... | 1989 | 2917521 |
| the hormonogenic sites of turtle thyroglobulin and their homology with those of mammals. | thyroglobulin (tg) from turtles previously injected with 125i was reduced, alkylated, and digested with trypsin. we purified the resultant peptides on hplc columns, determined their amino acid sequences and the locations of [125i]t4 and [125i]t3 residues, and compared them with established sequences from humans, cows, rabbits, rats, and guinea pigs. we found five major t4 peptides, three of which were homologous with the major hormonogenic sites a, b, and d of mammalian tg. site a, the highly co ... | 1989 | 2917515 |
| aging alters the activity of 5'-deiodinase in the adenohypophysis, thyroid gland, and liver of the male rat. | aging is characterized by a decreased secretion of thyroid hormones in rats associated with unchanged plasma tsh suggestive of impairments in the hypothalamo-pituitary-thyroid axis. since it is known that pituitary t3 is more determinant on tsh secretion than plasma t3, we measured in young (4 months) and old (26 months) male rats the concentration of t3 in the anterior pituitary gland and found that it was similar in young and old animals despite the low circulating levels of thyroid hormones. ... | 1989 | 2917513 |
| increases in thyroid gland blood flow after hemithyroidectomy in the rat. | after subtotal thyroidectomy, the thyroid gland remnant undergoes compensatory alterations in function and morphology. under the trophic stimulation of elevated plasma tsh concentrations, the thyroid remnant responds with an increase in hormone synthesis and secretion and, in addition, increases in mass. we have examined the alterations in thyroid blood flow which accompany increased secretion and growth after hemithyroidectomy (htx) in male sprague-dawley rats (200-220 g). at various times afte ... | 1989 | 2917508 |
| cardiac sympathetic afferent cell bodies are located in the peripheral nervous system of the cat. | studies of the stellate ganglion and middle cervical ganglion indicate that sympathetic efferent nerve activity can be modified by peripheral excitatory inputs and that these neural connections may function as pathways for a peripheral reflex at the level of the thoracic sympathetic ganglia. this excitatory synaptic input could have a soma in either the central or the peripheral nervous system. a study was designed to determine whether chronic decentralization (3 weeks) of the stellate ganglion ... | 1989 | 2917380 |
| partial laryngectomy and radiotherapy for supraglottic cancer: a conservative approach. | this is a retrospective study of 33 patients with supraglottic cancer treated with partial laryngectomy and moderate-dose radiotherapy at the university of virginia from 1967 through 1986. all patients had a 2-year minimum follow-up. ten patients received preoperative radiotherapy, and 23, postoperative radiotherapy. the 2-year adjusted survival rate was impressive at 97%. local control at 2 years was 96%, including one patient who was salvaged with total laryngectomy. control of the neck was 90 ... | 1989 | 2916823 |
| laser surgery for vocal cord carcinoma involving the anterior commissure. | endoscopic laser surgery is an established means of treatment for benign laryngeal lesions. laser surgery for early (stages i and ii) squamous cell carcinoma is still being tested. treatment of glottic tumors extending to the anterior commissure is in itself controversial. approximately 20% of all glottic tumors involve the anterior commissure, with only 1% of these lesions being purely anterior commissure tumors. the anatomy of the anterior commissure is such that an apparent t1 lesion may actu ... | 1989 | 2916820 |
| effects of chronic peritoneal dialysis on thyroid function tests. | peritoneal dialysis is associated with large losses of protein. in order to quantify thyroid hormone excretion in the dialysate and to examine the possibility that peritoneal dialysis may result in clinical hypothyroidism, nine endstage renal disease (esrd) patients undergoing either continuous ambulatory peritoneal dialysis (capd) or chronic intermittent peritoneal dialysis (ipd) were studied. total protein excretion in the peritoneal fluid was 21.5 +/- 2.1 g/24 h and did not vary with the mode ... | 1989 | 2916576 |
| thyroid function in hyperemesis gravidarum. | plasma total t4 (tt4), t3 (tt3), free t4 (ft4), free t3 (ft3), thyroxine binding globulin, hcg, and erythrocyte zinc content were measured in 43 women with uncomplicated pregnancy and in 71 patients admitted with hyperemesis gravidarum. plasma concentration of thyroid hormones in hyperemesis subjects showed wide variability and 32% of subjects had high tt4 (higher than mean +2 sd of normal pregnant subjects), 33% had high ft4, 20% had high tt3, and 20% had high ft3. red cell zinc content, a tiss ... | 1989 | 2916376 |
| control of enzyme activity by an engineered disulfide bond. | a novel approach to the control of enzyme catalysis is presented in which a disulfide bond engineered into the active-site cleft of bacteriophage t4 lysozyme is capable of switching the activity on and off. two cysteines (thr21----cys and thr142----cys) were introduced by oligonucleotide-directed mutagenesis into the active-site cleft. these cysteines spontaneously formed a disulfide bond under oxidative conditions in vitro, and the catalytic activity of the oxidized (cross-linked) t4 lysozyme w ... | 1989 | 2916125 |
| [the role of radiotherapy in the treatment of supraglottic laryngeal tumors. case reports]. | radiotherapy obtains better results when employed alone, in initial forms (t1-t2), and after surgery, when loco-regional relapse incidence reduces. personal results in the treatment of laryngeal cancer are reported in 281 patients. one-hundred-forty-seven patients treated with exclusive radiotherapy had 5-year global and ned survival of 32.7% and 26.6%; 5-year ned survival in particular was 78.7% for t1-t2 and 22.9% for t3-t4. subsequently 52.8% of patients relapsed. one-hundred-thirty-four pati ... | 1989 | 2915813 |
| intraarterial cisplatin and concurrent radiation for locally advanced bladder cancer. | between 1983 and 1987 25 patients with invasive bladder cancer (16 stage tumor 3 (t3) and nine stage t4) were treated with intraarterial cisplatin and concurrent radical radiation (20/25) or intraarterial cisplatin, concurrent preoperative radiation, and cystectomy (5/25). one patient died from treatment-related toxicity. other toxicities have been what one would expect from the individual treatment modalities except for a sensory sacral root neuropathy in 11 of 24 (46%) patients. twenty-three o ... | 1989 | 2915239 |
| t4, t3 and rt3 levels in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. | thyronine (t4), triiodothyronine (t3), and reverse-triiodothyronine (rt3) levels were evaluated in cerebrospinal fluid (csf) and in serum of 12 patients with definite amyotrophic lateral sclerosis (als) by specific radioimmunoassays. circulating microsomal and thyroglobulin antibodies were also evaluated. in all patients serum levels of t4, t3 and rt3 were within normal limits. in csf, the rt3 levels were significantly elevated to 0.118 micrograms/l (mean), the t4 levels were not significantly e ... | 1989 | 2915230 |
| affinity of single- or double-stranded oligodeoxyribonucleotides containing a thymine photodimer for t4 endonuclease v. | a gene for t4 endonuclease v was constructed by joining chemically synthesized oligodeoxyribonucleotides and expressed efficiently in escherichia coli under the control of the e. coli tryptophan promoter. overproduced t4 endonuclease v, which can cleave thymine photodimers as well as the corresponding phosphodiester linkage of dna, was used to investigate the precise mode of the reaction with single- or double-stranded synthetic dna fragments containing a thymine photodimer. the substrates, thre ... | 1989 | 2914925 |
| a proton and fluorine-19 nuclear magnetic resonance and fluorescence study of the binding of some natural and synthetic thyromimetics to prealbumin (transthyretin). | interactions between prealbumin and several thyromimetic compounds have been examined by proton magnetic resonance spectroscopy. one equivalent of thyroxine (t4) or reverse triiodothyronine (rt3) selectively broadens a number of protein signals, while addition of a second equivalent induces much less widespread changes. one equivalent of triiodothyronine (t3), however, produces much less dramatic changes, and effects comparable with t4 and rt3 are only apparent when a second equivalent binds. th ... | 1989 | 2914891 |
| paranasal sinus malignancy: a comprehensive update. | a retrospective analysis of 60 cases of paranasal sinus cancer in patients admitted between 1970 and 1985 was undertaken. forty-six tumors originated in the maxillary sinus, and 14 originated in the ethmoid sinuses. computed tomography, magnetic resonance imaging, and endoscopic sinus examination aided in early diagnosis of sinus cancer. computed tomography aided in staging tumors; caldwell-luc alone was inadequate for staging tumors invading deeper sites such as the orbits or pterygoid muscle. ... | 1989 | 2913425 |
| nuclear deoxyribonucleic acid ploidy in squamous cell bladder cancer. | flow cytometric analysis of nuclear deoxyribonucleic acid content was performed on 76 primary squamous cell bladder carcinomas treated between january 1970 and december 1975. patients were followed for a median of 10.1 years. nuclei were extracted from paraffin-embedded archival material and isolated nuclei were stained with propidium iodide. of the 76 tumors 73 were evaluable by flow cytometry providing high quality deoxyribonucleic acid histograms: 27 (37 per cent) showed a deoxyribonucleic ac ... | 1989 | 2913348 |
| altered responsiveness to sympathetic nerve stimulation and agonists of isolated left atria of diabetic rats: no evidence for involvement of hypothyroidism. | to clarify the role of hypothyroidism in diabetes-induced sympathetic neuropathy, we examined the responsiveness to sympathetic nerve stimulation and to agonists of the left atria of streptozotocin-induced diabetic rats, and compared it with those in hypothyroid, thyroxine(t4)-treated diabetic or t4-treated hypothyroid rats. positive inotropic response of isolated left atria to transmural nerve stimulation (tns) was examined in the presence of atropine. in diabetic rats, plasma triiodothyronine ... | 1989 | 2913281 |
| postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. | one hundred thirty-four patients with advanced head and neck cancer were treated with radical surgery and postoperative radiation therapy between october 1964 and october 1984. all patients had greater than or equal to 2 years and 84% had greater than or equal to 5 years of follow-up. all patients included in the study were scheduled to receive continuous-course irradiation following a major cancer operation for previously untreated squamous cell carcinoma of the oral cavity, oropharynx, hypopha ... | 1989 | 2912947 |
| effects of photoperiod, temperature and testosterone-treatment on plasma t3 and t4 levels in the djungarian hamster, phodopus sungorus. | the effects of photoperiod, temperature and testosterone treatment on plasma t3 and t4 levels were investigated in the djungarian hamster. plasma t3 level was affected by temperature (25 degrees c less than 7 degrees c) but not by photoperiod. plasma t4 level was affected by photoperiod (short day less than long day) at 25 degrees c. administration of testosterone increased plasma t4 level under short photoperiod at 25 degrees c. thus, higher plasma t4 level under long photoperiod at 25 degrees ... | 1989 | 2912765 |
| uptake of 3,5,3'-triiodothyronine by cultured rat hepatoma cells is inhibitable by nonbile acid cholephils, diphenylhydantoin, and nonsteroidal antiinflammatory drugs. | cellular uptake of t3 was examined using rat h4 hepatoma cells. uptake of [125i]t3 (10(-11) m) from serum-free medium was measured as the cell-associated counts retained by washed cells (2 x 10(6) per well). displaceable uptake was 84% of total uptake at 2 min (2.9% of total counts). t4, tetraiodothyroacetic acid, triiodothyroacetic acid, rt3, and d-t3 were 2-5% as effective as t3 in displacing uptake. nonequilibrium kinetics indicated a half-maximal uptake at 680 nm t3 with approximately 7 mill ... | 1989 | 2912709 |
| effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone. | hypothyroidism was induced in young female sprague-dawley rats by the addition of methimazole (0.67 mg/ml) to drinking water for a period of 7 weeks (7-14 weeks of age). the responses of the articular cartilage, epiphyseal growth plate cartilage, epiphyseal trabecular bone, and metaphyseal trabecular bone in the proximal tibia were assessed by structural parameters. in addition, replacement therapies were introduced for the last 2 weeks of the experimental period. these included 0.7 u/kg bw huma ... | 1989 | 2912707 |
| increased plasma 3,5,3'-triiodothyronine sulfate in rats with inhibited type i iodothyronine deiodinase activity, as measured by radioimmunoassay. | in contrast to the glucuronide conjugate, t3 sulfate (t3s) undergoes rapid deiodinative degradation in the liver and accumulates in rats and rat hepatocyte cultures if type i iodothyronine deiodinase activity is inhibited. we here report the ria of plasma t3s in rats treated with the antithyroid drugs propylthiouracil (ptu) or methimazole (mmi), of which only ptu inhibits type i deiodinase. male wistar rats were treated acutely by ip injection with 1 mg ptu or mmi/100 g bw and subsequently for 4 ... | 1989 | 2912698 |
| carbohydrate reactivation of thyroxine 5'-deiodinase (type ii) in cultured mouse neuroblastoma cells is dependent upon new protein synthesis. | the t3 concentration in brain predominantly reflects local production from t4 rather than t3 uptake from the circulating pool. we recently demonstrated that rat brain t3 content is increased by glucose feeding compared to chow feeding. one possible mechanism for this effect is an increase in brain t4 5'-deiodinase (5'-d) activity. our recent preliminary studies of neuroblastoma (nb) cells demonstrate that renewal of rpmi-1640 medium stimulates t4 5'-d type ii (nb t4 5'-d ii) activity in these ce ... | 1989 | 2912691 |
| vasoactive intestinal peptide in the anterior pituitary is increased in hypothyroidism. | vasoactive intestinal peptide (vip) and prl have been reported to be colocalized in rat lactotropes. to determine whether induced hypothyroidism, known to reduce pituitary prl concentration, also reduces pituitary concentration of vip, rats were treated with antithyroid drugs for 3 weeks. pituitary prl concentration in male rats (micrograms/mg protein) was markedly reduced by this treatment (9.4 +/- 1.0 vs. 2.3 +/- 0.4 when extracted at ph 1.1, 17.9 +/- 3.0 vs. 3.4 + 0.4 when extracted at ph 7.4 ... | 1989 | 2912685 |
| triiodothyronine, thyroxine, and tsh response to dexamethasone in depressed patients and normal controls. | in view of recent investigations concerning alterations of thyroid function in depression, the pre- and postdexamethasone levels of t3, t4, and tsh of 14 patients during depression and after recovery were studied, in addition to those of 27 healthy controls. a reduction of t3 and tsh levels was shown to be dependent on the depressive state, with a tendency to lower t4 levels after recovery. dexamethasone had a pronounced suppressive effect on tsh levels in healthy controls and in patients after ... | 1989 | 2912508 |
| tumor necrosis factor enhances replication of human immunodeficiency virus (hiv) in vitro. | the effect of tumor necrosis factor (tnf) on the replication of human immunodeficiency virus type 1 (hiv-1) was investigated in several t4 lymphocyte cell lines. tnf markedly enhanced the cytopathogenicity of hiv-1, virion-associated reverse transcriptase (rt) activity in the cell culture supernatant, and viral antigen expression in molt-4 cells as early as 3 days after hiv-1 infection. a slight increase in rt activity was also observed in the supernatant of h9 cell cultures exposed to tnf. howe ... | 1989 | 2912452 |
| comparison of maternal to fetal transfer of 3,5,3'-triiodothyronine versus thyroxine in rats, as assessed from 3,5,3'-triiodothyronine levels in fetal tissues. | thyroxine (t4) is transferred from the mother to the hypothyroid rat fetus late in gestation, mitigating t4 and t3 deficiency in fetal tissues, the brain included. we have now compared the effects of maternal infusion with t3. normal and thyroidectomized rats were started on methimazole (mmi) on the 14th day of gestation, given alone, or together with a constant infusion of 0.45 micrograms (0.69 nmol) t3 or of 1.8 microgram (2.3 nmol) t4/100 g per day. maternal and fetal samples were obtained at ... | 1989 | 2911938 |
| thyroxine transport and distribution in nagase analbuminemic rats. | the postulate that thyroxine (t4) in plasma enters tissues by protein-mediated transport or enhanced dissociation from plasma-binding proteins leads to the conclusion that almost all t4 uptake by tissues in the rat occurs via the pool of albumin-bound t4 (pardridge, w. m., b. n. premachandra, and g. fierer. 1985. am. j. physiol. 248:g545-g550). to directly test this postulate, and to test more generally whether albumin might play a special role in t4 transport in the rat, we performed in vivo ki ... | 1989 | 2910905 |
| detection by 32p-postlabeling of thymidine glycol in gamma-irradiated dna. | the 32p-postlabeling method has been adapted for the analysis of thymidine-cis-glycol-3'-phosphate (cis-dtgp,cis-5,6-dihydroxy-5,6-dihydrothymidine-3'-phosphat e). cis-dtgp was isolated and purified from normal nucleotides by phenylboronate affinity chromatography and phosphorylated by t4 polynucleotide kinase in presence of 1 mm becl2 at ph 7.5. these modifications of the postlabeling method resulted in a 5'-phosphorylation of dtgp with a labeling efficiency of up to 20% whereas the natural nuc ... | 1989 | 2910530 |
| evidence against the importance in the disease process of antibodies to bovine thyroid-stimulating hormone found in some patients with graves' disease. | the antibody to tsh (tsh-ab) found in some patients with graves' disease may be either an antiidiotype (anti-id-ab) to the tsh receptor antibody (trab) or the antigen (idiotype) for which the anti-id-ab is in fact trab. four groups have found antibodies to bovine tsh (btsh-ab) in graves' disease patients in a tsh binding-inhibiting immunoglobulin (tbii) rra that uses [125i]btsh. in this assay serum samples containing btsh-ab give highly negative tbii values. the purpose of this study was to look ... | 1989 | 2909548 |
| ontogeny of human suppressor inducer t cell subset. | a t cell subset (t4+,2h4+) has recently been identified, which acts as an inducer of t8+ suppressor cells; however 2h4 molecules have not been detected in thymuses from normal individuals or on the surface of immature thymocyte clones. in the present study, t4+,2h4+ and t8+,2h4+ cells have been found in maternal and new-born blood samples. however, only a small percentage of 2h4+ cells were detected in human fetal thymus, bone marrow, liver and spleen, thus suggesting that t cells acquire these ... | 1987 | 2908511 |
| human anti-idiotypic t lymphocyte clones are activated by autologous anti-rabies virus antibodies presented in association with hla-dq molecules. | the regulatory function of antigen-specific t cells in human antibody responses to protein and carbohydrate determinants of many viral and bacterial antigens has extensively been studied in systems involving in vitro triggering of b cells by antigens or polyclonal activators. although amply documented in experimental murine models, the existence of t helper cells with receptor specificity for idiotypic determinants of b cell immunoglobulins has not been demonstrated in a human system. we are int ... | 1987 | 2908179 |
| monocyte defect causes decreased automlr in multiple sclerosis patients. | we have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (ms) have a defect in stimulating autologous and allogeneic t lymphocytes. this defect was found to correlate with disease activity. we report here that t4+ cells from ms patients proliferate weakly in the autologous mixed lymphocyte reaction (automlr). furthermore, we provide direct proof that the depressed t4+ cell proliferation is due to the monocyte functional (stimulatory) defect. | 1988 | 2908171 |
| hematologic and immunologic changes in hairy cell leukemia patients treated with alpha interferon. | we prospectively evaluated hematologic and immunologic changes in fourteen hairy cell leukemia patients treated with alpha interferon. prompt disappearance of circulating hairy cells, and recovery of peripheral blood counts was observed in all patients whereas only four patients had complete disappearance of hairy cell infiltrates from their bone marrow. immunologic changes included a statistically significant increase of nk cell activity in the whole group and a slight decrease in circulating t ... | 1988 | 2907963 |
| [effect of various beta-adrenolytic drugs and calcium channel blockers (nifedipine) on serum levels of t3 and t4 in patients with hyperthyroidism and simple goiter]. | 1988 | 2907475 | |
| [cell membrane changes and skin diseases]. | biological membranes are laminar bilayers of lipoids with thermolabile biophysical properties. changing temperatures not only result in altered polarity and permeability of the membranes, but also in changes of the various membrane receptors (e.g. histamine and beta-adrenergic receptors) and the cell makers. in healthy persons, lower temperatures (25 degrees) lead to elevated suppressor properties, and the t4 ratio is below 1.0. at 37 and 41 degrees c, there is a growing number of helper cells, ... | 1988 | 2907212 |
| lymphocytes subset in hyperandrogenic women with polycystic ovarian disease. | the correlation between the sex steroids and the immune system is already known but the relationships between testosterone, progesterone, estradiol, cortisol and the immune system are still controversial. the authors have studied lymphocytes subset in ten women with polycystic ovarian disease (pcod); it was observed: 1) a decrease of t8 in 64% and of natural killer activity (nk) in 60% of patients, and an increase of t4/t8 ratio in 55%; 2) a significant negative correlation between androstenedio ... | 1988 | 2906494 |
| [electron microscopic immunohistochemistry in the diagnosis of human lymphotropic viral diseases]. | immunohistochemistry is finding an ever increasing application for electron microscopic diagnosis of human viral diseases. certain progress has been made in the use of peroxidase-dab/oso4 as an electron-dense marker, and colloid gold. the paper discusses immunohistochemistry application for electron microscopic detection of such lymphotropic viruses as vsv (virus of vesicular stomatitis cultured in mink's lung cells), htlv-1 (virus of human t4-cell c91pl lymphoma culture) and htlv-iii/hiv-1 (vir ... | 1988 | 2905847 |
| mutagenicity of topoisomerase-active agents in bacteriophage t4. | recently, the antitumor agent 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-amsa) was shown to revert a frameshift mutant of t4 (rfc11), and its mutagenicity was shown to be mediated by t4 dna topoisomerase ii [ripley et al.: j mol biol 200: 665-680, 1988]. here we report dose-response data on the mutagenicity and toxicity of m-amsa in t4 rfc11. we find that m-amsa is among the most potent frameshift mutagens observed in t4, inducing a 10-fold increase in mutant frequency in the absence of ... | 1988 | 2905838 |
| [prognostic significance of the t4 lymphocyte count in patients infected with cdc class ii and iii hiv]. | from 1985 to 1987 101 patients infected with the human immunodeficiency virus (hiv) were seen at our outpatient clinic and prospectively analyzed in a cohort study. we evaluated the follow-up in 41 patients of cdc classes ii and iii with regard to the number of t-helper lymphocytes (t4) and clinical progression. the patients consisted of 24 i.v. drug addicts, 11 homosexuals and 6 persons with other or multiple risk factors for hiv infection. patients with a t4 count of less than 400/mm3 at the f ... | 1988 | 2905830 |
| cellular immunity and the hypothalamic-pituitary axis in major affective disorder: a preliminary study. | to assess cellular immune status and the hypothalamic-pituitary axis in patients with major depression, we examined peripheral blood mononuclear cells and measured the plasma levels of four neurohormones. eleven patients with major depression had increased % of t4 lymphocytes and decreased concanavalin (con a) stimulated t lymphocyte proliferation when compared with 11 age-, sex-, and race-matched control subjects. percent of total lymphocytes labeled as all t lymphocytes, all b lymphocytes, and ... | 1988 | 2905815 |
| a randomized placebo-controlled trial of recombinant human interferon alpha 2a in patients with aids. interferon alpha study group. | we performed a randomized, double-blind, placebo-controlled trial to assess the tolerance and efficacy of recombinant human interferon alpha 2a (roferon a) in patients with acquired immunodeficiency syndrome (aids) without kaposi's sarcoma. a total of 67 patients were enrolled in five medical centers from october 1983 through april 1986, and received either placebo, 3 million units, or 36 million units of interferon alpha three times a week for 12 weeks. there were no significant differences in ... | 1988 | 2905740 |
| [aids. excessive decrease in t4 lymphocytes]. | 1988 | 2905322 | |
| histamine-induced regulation of il-2 synthesis in man: characterization of two pathways of inhibition. | histamine at molar concentrations ranging from 10(-5) to 10(-7) exerted an inhibitory effect upon il-2 synthesis by peripheral blood mononuclear cells in normal man; two pathways of inhibition are described. the first pathway was found to alter the t4 lymphocytes which, in the system used in this study, synthesized nearly 90% of the total il-2 production and had no suppressive activity. this suggests that histamine can act at the level of il-2-producing cells. the second pathway of inhibition wa ... | 1988 | 2905136 |
| impaired ability of t4+ lymphocytes in the active stage of congenital hypoplastic anemia to promote in vitro growth of blood erythroid burst-forming units (bfu-e). | 1988 | 2904723 | |
| [study of immunologic parameters in parenteral drug addicts (pda) with condylomata acuminata]. | a study is made of the state of cell and humoral immunity in parenteral drug addicts both with and without genital warts. the results reveal alterations in the lymphocyte subpopulations, with a decrease in the t-helper/t-suppressor (t4+/t8+) ratio of both groups of patients. these alterations were more pronounced in those patients with genital warts (p less than 0.05). the alterations in humoral immunity, expressed as a hypergammaglobulinemia igg and igm, were similar in both groups. none of the ... | 1988 | 2904516 |
| effect of propranolol in combination with tsh and ovine prolactin on plasma thyroid hormone levels and in vitro hepatic monodeiodination of thyroxine in brook charr, salvelinus fontinalis (mitchill). | 1. ovine tsh stimulated an increase in plasma t4 levels in brook charr, but plasma t3 levels, hepatic t3 content and hepatic t4-monodeiodination to t3 were unaffected. tsh-induced plasma t4 levels were further enhanced in propranolol-pretreated fish. 2. fish treated with ovine prolactin + tsh had elevated plasma t3 levels, hepatic t3 content and hepatic t4-monodeiodination rates compared with tsh-treated animals. propranolol-pretreatment further enhanced hepatic t4-monodeiodination in these fish ... | 1988 | 2904348 |
| effect of early feed restriction in male broiler chicks on plasma metabolic hormones during feed restriction and accelerated growth. | 1. plasma gh was greater (p less than 0.05) on day 12 in ad libitum-fed birds compared to restricted chicks. conversely, maximum gh levels were found to occur in the nutrient restricted chicks during the period of accelerated growth (day 42). 2. a significant decline in circulating insulin concentrations with advancing age was evident in both ad libitum-fed and restricted chicks. 3. feed restriction significantly suppressed circulating t3 in restricted chicks, with concentrations returning to co ... | 1988 | 2904334 |
| development of hyperthyroidism following primary hypothyroidism: a case report with changes in thyroid-related antibodies. | we report a 48-year-old woman who developed hyperthyroidism following primary hypothyroidism. the serum t4 level was initially low and serum tsh level was high with clinical signs of hypothyroidism. the thyroid gland was not enlarged. therapy with l-t4 was started. three years later she developed hyperthyroidism; serum free t4 increased to 29.1 pmol/l after cessation of l-t4 therapy. the 123i thyroid uptake was increased with no suppression by exogenous t3. when she was hypothyroid, the activity ... | 1988 | 2903804 |
| a highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-hiv activity of antiviral compounds in mt-4 cells. | infection of human t4 lymphocyte mt-4 cells with human immunodeficiency virus (hiv) results in cell death 4-5 days after infection. we have now developed a highly sensitive and rapid procedure for estimating the cytopathic effect of hiv in mt-4 cells. this method is based on fluorometric as well as flow cytometric evaluation of hiv-infected mt-4 cultures. by the use of fluorescein diacetate (fda), a non-fluorescent diacetyl fluorescein ester that becomes fluorescent upon hydrolysis by esterases ... | 1988 | 2903196 |
| large cell mycosis fungoides at the tumor stage. unusual t8, t4, t6 phenotypic expression. | we report a case of mycosis fungoides in a 52-year-old woman with a huge skin tumor on her thigh in which the predominant cells were lymphoblastic and histiocytic large cells. the neoplastic cells showed strong suppressor and helper t-cell subset markers, and were partially positive for the cortical thymocyte (okt6) subset marker. | 1988 | 2902810 |
| [t4/t8 ratio in bronchoalveolar lavage fluid: sensitivity and specificity for the diagnosis of sarcoidosis]. | 1988 | 2902607 | |
| tonic descending inhibition of the spinal cardio-sympathetic reflex in the cat. | electrical stimulation of the left inferior cardiac nerve elicited a two-component reflex potential (spinal and supraspinal reflexes) in the ipsilateral white ramus t3 from which recordings were made in chloralose-anaesthetised cats. reversible interruption of all spinal pathways achieved by cooling the spinal cord at c2/c3 produced an enhancement of the spinal reflex and abolished the supraspinal reflex, the latter usually being the more prominent reflex potential prior to spinal cord block. th ... | 1988 | 2902120 |
| endocrine status and growth after malignancy treated in childhood or adolescence. | six girls and three boys, asymptomatic after treatment for acute lymphoblastic leukemia (all) or endodermal sinus tumor (est), were investigated for endocrine status and growth. serum follicle stimulating hormone (fsh), luteinizing hormone (lh), estradiol (e2), prolactin (prl), testosterone (t), androstenedione (a), dehydroepiandrosterone sulfate (dheas), testosterone binding capacity (tebc), 17 alpha-hydroxyprogesterone (17-ohp), progesterone (p), thyroxine (t4), thyroid stimulating hormone (ts ... | 1988 | 2902044 |
| infection of b lymphocytes by the human immunodeficiency virus and their susceptibility to cytotoxic cells. | the t4 molecule (cd4) is an important component of the human immunodeficiency virus (hiv) receptor. as yet, no other component has been demonstrated. we report here that two cell lines, a b lymphoblastoid cell line (gupta) and a glial cell line (heb) derived from human embryonal brain tissue, are productively infectable with two distinct isolates of hiv as judged by electron microscopy and immunological and virological studies. these two cell lines do not display detectable surface cd4 glycoprot ... | 1988 | 2901961 |
| induction of suppressor cells to t- and b-cell proliferative responses and immunoglobulin production by monoclonal antibodies recognizing the cd3 t-cell differentiation antigen. | monoclonal antibodies (mab's) recognizing the cd3 t-cell differentiation antigen induced the generation of suppressor cells. these cells inhibited (1) proliferative responses of human peripheral blood mononuclear cells (pbmc) to pha and allogeneic cells in mixed leukocyte culture; (2) proliferative responses of purified e-rosette-negative cells to staphylococcus aureus cowans i; and (3) de novo immunoglobulin synthesis and secretion in the pokeweed mitogen (pwm)-induced differentiation system. m ... | 1988 | 2901914 |
| lymphocyte subset t4/t8 ratio in systemic lupus erythematosus: correlation with disease activity, laboratory abnormalities and treatment. | lymphocyte subsets were studied in forty-nine patients with sle using monoclonal antibodies and flow cytometry. a decrease in t4+ reactive cells (helper/inducer) was the most frequent observation. decreased t4/t8 ratios were seen in patients with increasing clinically active disease, patients with positive anti-ds-dna, positive anti-rnp antibodies and patients with low ch50 activity. however, low t4/t8 ratios were seen in patients with negative anti-sm. low t4/t8 ratios were also observed in pat ... | 1988 | 2901842 |
| detection of the thyroxine-binding globulin (tbg) gene in six unrelated families with complete tbg deficiency. | t4-binding globulin (tbg) is a glycoprotein of hepatic origin which transports thyroid hormone in serum. inherited tbg defects in man are x-chromosome linked and are expressed in hemizygotes as complete deficiency, partial deficiency, or excess. since tbg is not necessary for thyroid hormone action, affected subjects are healthy. using dna probes for human tbg, we searched for restriction fragment length polymorphisms in six affected males belonging to 6 unrelated families with inherited complet ... | 1988 | 2901429 |
| plasma amino acid pattern of patients with hiv infection. | we measured the free amino acids in plasma of 58 patients with hiv infection and in six persons in the risk group. the hiv+ patients had significantly increased concentrations of arginine, phenylalanine, and glutamate in comparison with both age- and sex-matched controls and the members of the risk group. glutamate concentrations increased only in an advanced stage of the disease (wr 5 and 6 of the walter reed staging classification), whereas arginine and phenylalanine increased independently of ... | 1988 | 2901300 |
| the molecular genetics of the incision step in the dna excision repair process. | this review describes the evolution of research into the genetic basis of how different organisms use the process of excision repair to recognize and remove lesions from their cellular dna. one particular aspect of excision repair, dna incision, and how it is controlled at the genetic level in bacteriophage, bacteria, s. cerevisae, d. melanogaster, rodent cells and humans is examined. in phage t4, dna is incised by a dna glycosylase-ap endonuclease that is coded for by the denv gene. in e. coli, ... | 1988 | 2900858 |
| [hepatic involvement in hiv 1 virus infection]. | one hundred consecutive patients with serum antibodies against hiv 1 were evaluated for the prevalence and the type of liver injury. according to the cdc classification, 16 patients belonged to group ii (asymptomatic patients), 47 to group iii (persistent generalized lymphadenopathy) and 37 to group iv (11 constitutional disease, 19 secondary infectious diseases, 5 secondary cancers, one chronic lymphoid interstitial pneumonitis and one visceral leishmaniasis). liver histology was studied in 32 ... | 1988 | 2900180 |
| changes in plasma thyroid hormones, luteinizing hormone (lh), estradiol, progesterone and corticosterone of laying hens during a forced molt. | 1. circulating concentrations of iodothyronines, luteinizing hormone(lh), estradiol(e2), progesterone and corticosterone were measured in hens before, during, and after a forced molt induced by fasting. 2. corticosterone increased at the onset of molt, peaked at the maximal molt and returned to pre- and post-molt levels. lh, e2 and progesterone declined during the molt, and the decline was coincident with the cessation of egg production. 3. thyroxine(t4), triiodothyronine (t3) and reverse triiod ... | 1988 | 2900123 |
| thyroid function in a lizard, a tortoise and a crocodile, compared with mammals. | 1. thyroid activity was examined in the lizard, trachydosaurus rugosus, the tortoise chelodina longicollis and the crocodile, crocodylus johnstoni, acclimated to 20-22 degrees c and 30-32 degrees c. thyroidal uptake and release of 125i, plasma concentrations of t3 and t4 were measured as was resting oxygen consumption (at 30 degrees c) before and after both thyroidectomy and thyroxine injections. 2. all three species showed 125i uptake at both temperatures and showed no thyroidal release of 125i ... | 1988 | 2900104 |
| [clinical studies on abnormal thyroid stimulators in patients with graves' disease. i. a sensitive assay for thyroid-stimulating antibodies using cultured porcine thyroid cells and polyethylene glycol precipitation of serum]. | the activities of thyroid-stimulating antibody (tsab) in serum from patients with graves' disease were measured by a sensitive assay, using cultured porcine thyroid cells and the precipitation from serum with polyethylene glycol (peg), and the activities were compared with those of thyrotropin binding inhibitor immunoglobulin (tbii), measured by the commercial assay kit. porcine thyroid cells after digestion were cultured for 15-18 hours with tsh of 1-10,000 microu/ml or the precipitations of se ... | 1988 | 2899523 |
| thyroid hormone action on biosynthesis of somatostatin by fetal rat brain cells in culture. | thyroid hormone (th) action on somatostatin (srif) secretion and synthesis by fetal rat brain cells in culture was studied. cortical and hypothalamic brain cells were maintained as monolayer cultures for 7-10 days. t3, t4, and [3h] phenylalanine [( 3h]phe) (40 microci/plate) were added simultaneously for 48 h. alternately, cultures were pulse labeled with [3h] phe for only the last 3 h, after being exposed to th for 45 h. 3h-labeled srif-like material [( 3h]ir-srif) was purified by immunoaffinit ... | 1988 | 2899503 |
| rna processing and multiple transcription initiation sites result in transcript size heterogeneity in maize mitochondria. | variation in the length of the 5' non-coding region of mitochondrial gene transcripts could result from multiple transcription initiation sites or post-transcriptional processing events. to distinguish between these possibilities, we have utilized the in vitro capping reaction catalyzed by guanylyl transferase to specifically label the 5' end of primary, unprocessed transcripts. hybridization of in vitro capped mtrna to immobilized dna from the 5' flanking regions of 26 s, 18 s and 5 s rrna gene ... | 1988 | 2897071 |
| hla haplotype a1 b8 dr3 as a risk factor for hiv-related disease. | of 32 patients exposed to a single batch of factor viii contaminated with human immunodeficiency virus (hiv), 18 became antibody positive. serial t cell subset analyses over the succeeding four years have shown a progressive decline in circulating t4 cells in those 18 but no change in the 14 who remain seronegative. 2 of the seroconverters have died and a further 7 have symptoms attributable to hiv infection. in the group as a whole, the hla haplotype a1 b8 dr3 was weakly associated with an incr ... | 1988 | 2897006 |
| the intermediolateral cell column of the thoracic spinal cord is comprised of target-specific subnuclei: evidence from retrograde transport studies and immunohistochemistry. | in this study we examined the hypothesis that the intermediolateral cell column (iml) of the thoracic spinal cord, the nucleus from which preganglionic sympathetic neurons originate, provides an anatomical substrate through which selective regulation of sympathetic nervous system targets is accomplished. preganglionic sympathetic neurons of rats were retrogradely labeled by the simultaneous exposure of the cervical sympathetic trunk (cst) and the adrenal medulla to fluoro-gold and true blue, con ... | 1988 | 2896766 |
| development of aids, hiv seroconversion, and potential co-factors for t4 cell loss in a cohort of intravenous drug users. | a cohort of 334 intravenous (iv) drug users from new york city drug treatment programs were followed over a mean 9-month period. among the 165 who were seropositive at enlistment, four developed clinical aids, for an annual rate of 3%. elevated iga was a significant predictor of developing aids. among 72 subjects who were initially seronegative and who were re-interviewed, four were seropositive at follow-up, for a seroconversion rate of 7% per year among seronegatives. among seropositive subjec ... | 1987 | 2896511 |
| dibutyryl camp induction of type ii 5'deiodinase activity in rat brain astrocytes in culture. | dibutyryl camp treatment of cultured rat astrocytes results in the rapid appearance of t4 to t3 conversion catalyzed by type ii iodothyronine 5'deiodinase, without altering other deiodinating pathways. induction of enzyme activity was time-dependent with a lag period of 60 min, reaching plateau levels after 6-8 hours, and required continued synthesis of mrna and new protein. isoproterenol also induced t4 to t3 converting activity through beta-adrenergic receptor mediated interactions. these data ... | 1988 | 2895644 |
| neonatal thyroid disease: differential expression in three successive offspring. | neonatal thyroid disease, manifested as either hyperthyroidism or hypothyroidism, has been described in the offspring of women with autoimmune thyroid disorders. we report clinical and laboratory observations in a mother with autoimmune thyroiditis who gave birth to three children with different forms of thyroid dysfunction. the first child was clinically normal, the second child had transient neonatal hyperthyroidism, and the third child had neonatal hypothyroidism. after the birth of the secon ... | 1988 | 2895120 |
| effects of amiodarone on thyroid hormone-responsive gene expression in rat liver. | the hypothesis that amiodarone (am) acts by inducing a local 'hypothyroid-like' state in thyroid hormone-responsive tissues was investigated in rat liver. hypothyroid rats, pretreated orally for 8 consecutive days with am (200 mg/kg) or water, were given a single i.p. injection of equimolar doses of t4, t3 or rt3 (1.00 to 1.20 mg/kg). six hours later, the rats were killed and liver nuclear t3 receptor occupancy was determined. simultaneously, the activity of two thyroid hormone-responsive enzyme ... | 1987 | 2895059 |
| [comparison of the action kinetics of alcuronium and vecuronium by electromyographic monitoring]. | twenty-eight asa i or asa ii adults undergoing microsurgery were anaesthetized according to a standard protocol using droperidol, phenoperidine and thiopentone followed by enflurane. the patients were randomly assigned to two homogeneous groups: the first group (n = 14) received 0.2 mg.kg-1 alcuronium, whereas the second group (n = 14) received 0.08 mg.kg-1 vecuronium. there was no reinjection of either drug and curarization tapered off spontaneously. neuromuscular monitoring was begun once anae ... | 1988 | 2894789 |
| prokaryotic dna replication mechanisms. | the three different prokaryotic replication systems that have been most extensively studied use the same basic components for moving a dna replication fork, even though the individual proteins are different and lack extensive amino acid sequence homology. in the t4 bacteriophage system, the components of the dna replication complex can be grouped into functional classes as follows: dna polymerase (gene 43 protein), helix-destabilizing protein (gene 32 protein), polymerase accessory proteins (gen ... | 1987 | 2894677 |
| in vitro effects of 4-hydroxyperoxycyclophosphamide on human immunoregulatory t subset function. | treatment of t cells in vitro with low concentrations of 4-hydroperoxycyclophosphamide (4-hc) is known to result in immunopotentiation of both t and b cell effector function in a manner analogous to that of cyclophosphamide administered in vivo. a previous study demonstrated that augmentation of polyclonal immunoglobulin secretion occurs following pretreatment of autologous collaborating t cells with low concentrations of 4-hc as a result of blockade of suppressor effector induction from suppres ... | 1987 | 2893863 |
| effect of two thymosin fraction 5 polypeptides on human peripheral blood lymphocytes. | thymosin fraction 5 polypeptides beta 4 and alpha 1 were tested for their ability to affect certain immunological parameters of human peripheral blood lymphocytes (pbl). pbl were cultured with various concentrations of the peptides for 24 hours. thymosin beta 4 was found to induce a significant decrease in the expression of the fc alpha receptors of pbl, as well as in their ability to express antibody dependent cellular cytotoxic (adcc) activity. in addition, this peptide had the ability to incr ... | 1987 | 2893819 |
| interleukin-2 receptor-inducing factor(s) in adult t cell leukemia. | the expression of the interleukin-2 receptor (il-2-r) is regulated by transcriptional and post-transcriptional mechanisms. il-2-r gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (pma) and forskolin (fk), a direct activator of adenylate cyclase. htlv-i(+) leukemic t cells and t cell lines from patients with adult t cell leukemia (atl) continuously expressed il-2-r without production of il-2. however, there was no abnorm ... | 1987 | 2893506 |
| thyroid stimulating immunoglobulin bioactivity during carbimazole therapy as measured by the cytochemical bioassay. | most assays of thyroid stimulating immunoglobulin (tsi) are unsuitable for the quantitation of tsi during the treatment of graves' hyperthyroidism because assay insensitivity results in some negative responses. therefore the sensitive cytochemical bioassay was used to investigate the effect of carbimazole on tsi levels as a possible mechanism for the induction of the increased remission rate which is characteristic of thionamide therapy. twelve patients were studied before therapy for de-novo gr ... | 1987 | 2892877 |
| effects of short- and long-term administrations of famotidine and ranitidine on some pituitary, sexual and thyroid hormones. | the endocrine effects of short-term (4 weeks) and long-term (6 months) oral administration of famotidine (40 and 20 mg nocte, respectively) and ranitidine (300 and 150 mg nocte, respectively), were investigated in 20 male patients with duodenal ulcers. basal prl, lh, fsh and tsh serum levels were evaluated and their response to specific releasing factors, and basal blood levels of some sexual (e2, p, t) and thyroid (t3, t4) hormones. none of the treatments modified basal and rh-stimulated levels ... | 1987 | 2892657 |
| blood levels of thyroid hormones and certain metabolites in relation to moult in the harp seal (phoca groenlandica). | 1. changes in blood levels of thyroxine (t4), triiodothyronine (t3), free fatty acids (ffa), glucose, pyruvic acid and lactic acid in the harp seal during moult, were studied. 2. serum levels of both t4 and t3 showed significant increase in the moult phase from that in the pre-moult phase. while t4 level continued to remain high during the early and late post-moult phases, t3 level dropped in the latter two phases to the same low pre-moult level. 3. the t3/t4 ratio was significantly higher durin ... | 1987 | 2892641 |
| [diagnostic use of the grf test in the study of gh secretion]. | a good response after an intravenous bolus of grf-1-29 nh2 in patients with hypopituitary dwarfism localities the site of the gh-deficiency in the hypothalamus (grf deficiency). these patients could be treated with gh and grf. never the less some patients with hypothalamic responses after trh don't respond after grf. probably these non responders need grf in pulsatile or prolonged administration and t4 substitution before and during the test if tsh is also deficient. at least some cases without ... | 1987 | 2892455 |
| an evaluation of the anti-androgen effects associated with h2 antagonist therapy. | the effect of two different h2-receptor antagonists, nizatidine and cimetidine, on sperm counts and hypothalamic-pituitary-gonadal function as determined by responses to provocative gonadotropin releasing factor, gnrh, thyrotropin releasing factor, trh, and clomiphene were compared to those of men receiving placebo medication. all subjects studied gave informed written consent and were greater than 18 but less than 55 years of age. sperm concentrations in collected semen specimens, and gnrh and ... | 1987 | 2892252 |
| release of soluble pilin antigen coupled with gene conversion in neisseria gonorrhoeae. | gene conversion appears to be the frequent mechanism in neisseria gonorrhoeae that leads to an altered expression of pilin, the subunit component of the pili. in this process segments of variable sequence information, the minicassettes, are transferred from silent storage loci into an expression locus. as a putative consequence of the rearrangement in the pile gene, gonococci can enter a different phase of pilin production. although the removal of a 7-amino acid leader peptide results in the pro ... | 1987 | 2892194 |
| phase i studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (azt). | five dose regimens of 2',3'-dideoxycytidine (ddc) were administered, intravenously for 2 weeks then orally for 4 or more weeks, to 20 patients with acquired immunodeficiency syndrome (aids) or aids-related complex (arc). ddc was well absorbed from the gut and crossed the blood-brain barrier. 10 of the 15 patients who received 0.03-0.09 mg/kg every 4 h had increases in their absolute number of t4+ t cells at week 2 (p less than 0.05), though in many these rises were not sustained. 11 of 13 evalua ... | 1988 | 2891981 |
| tsh-receptor antibodies in mothers with graves' disease and outcome in their offspring. | blood was taken from 56 selected newborn babies whose mothers had graves' disease, to assess the relation between their thyroid function and the presence of thyrotropin (tsh) binding inhibitor immunoglobulins (tbii) and thyroid stimulating antibodies (tsab) in maternal serum. all the mothers of the thyrotoxic babies had both these tsh receptor antibodies in their serum. however, most of the mothers whose thyroid function had been well controlled in pregnancy gave birth to normal babies. 15 babie ... | 1988 | 2891888 |
| [atracurium and vecuronium: interaction with three orally administered calcium antagonists in animal experiments]. | interactions between calcium antagonists (ca) and muscle relaxants have been reported however due to the extremely high dosages of ca used in these studies, the clinical relevance of the observed interactions has been questioned. in order to simulate clinical practice--which entails long-term oral treatment and significant reductions in systolic blood pressure--ca were administered to rats orally (by gavage) for 8 days at a dosage that induced a systolic blood pressure decrease of not more than ... | 1987 | 2891318 |
| anapsos, an antipsoriatic drug, in atopic dermatitis. | an open, controlled study was carried out in young patients with atopic dermatitis, who during one month received oral anti-psoriatic drug, anapsos (n = 46), or antihistamines (n = 30), simultaneously with topic applications. the activity and extension of the cutaneous lesions improved under both treatments, but more markedly with anapsos in spite of the fact that topical applications did not contain steroids in the group treated with anapsos, and the effect was still appreciable several months ... | 1987 | 2891287 |
| effects of toxic doses of a novel histamine (h2) antagonist on the rat thyroid gland. | the oral administration of high doses of a histamine h2 antagonist sk&f 93479 (up to 1000 mg/kg/day) to male rats for up to 21 days resulted in alterations in thyroid morphology indicative of increased activity of the thyroid gland. measurement of thyroidal 125i incorporation substantiated these findings. treatment with sk&f 93479 resulted in a dose-dependent increase in thyroidal iodide incorporation. this was apparent after a single dose of the compound and was reversible after dosing for 7 da ... | 1987 | 2890563 |
| an evaluation of priming with vecuronium. | priming with vecuronium was evaluated in three groups of patients. group 1 (n = 10) received tubocurarine 0.05 mg kg-1, group 2 (n = 19) received physiological saline and group 3 (n = 21) received vecuronium 0.012 mg kg-1. after 4 min maximum inspiratory pressure was measured. anaesthesia was induced with thiopentone 6-8 mg kg-1 and controlled ventilation with nitrous oxide and oxygen via a face mask instituted. the ulnar nerve was stimulated at the wrist. at 5 min group 1 patients received suxa ... | 1987 | 2890364 |
| seasonal changes in circulating levels of thyroid hormones are not dependent on the age in djungarian hamsters phodopus sungorus. | 1. plasma levels of total and free thyroxine (t4; ft4) and triiodothyronine (t3; ft3) were measured by radioimmunoassay in adult and senescent djungarian hamsters at different times of the year. 2. seasonal changes of both hormones were found in adult and senescent hamsters. 3. however, except for total thyroxine, the patterns were different in both groups of hamsters. 4. these results suggest, that in djungarian hamsters age-related changes of thyroid function do not affect the secretory activi ... | 1987 | 2889578 |
| [antagonism of an intubation dose of vecuronium]. | to study the problem of rapid antagonization of an intubation dose of vecuronium (0.08 mg/kg), 36 surgical patients undergoing barbiturate/halothane anesthesia were given edrophonium 0.5, 0.75, and 1.0 mg/kg or neostigmine 0.04, 0.06, and 0.08 mg/kg precisely 5 min following injection of the muscle relaxant. t1 twitch (t1/tc) and train-of-four (tof) ratios (t4/t1) of the hypothenar muscle were monitored every 20 s with the aid of a commercially available emg monitor (datex-relaxograph). as docum ... | 1987 | 2889392 |
| immunosensors. | the current trends and future aspects of the research and development of immunosensors are overviewed. a non-labelled immunosensor, whose selectivity depends on immunochemical affinity of an antigen for its corresponding antibody, has been developed as the basis for the potentiometric determination of an antigen, with an antibody-bound membrane or electrode. non-labelled immunosensors for syphilis antibody, blood typing, human chorionic gonadotropin (hcg), and human serum albumin have been inves ... | 1987 | 2889226 |
| [functional interrelations of monoamines, thyrotropic hormone and thyroid hormones in hyperprolactinemia]. | functional interrelationships of serotonin, dopamine, prolactin, trh and thyroid hormones in patients with hyperprolactinemia were studied. altogether 26 patients with amenorrhea in hyperprolactinemia without clinical signs of disorder of thyroid function were examined. the levels of serotonin and dopamine were determined by spectrofluorimetry, the level of hormones was determined by a radioimmunoassay. an increase in the level of serotonin and a decrease in the level of dopamine in all the pati ... | 1987 | 2889207 |
| effects of somatostatin analogue sms 201-995 in non-insulin-dependent diabetes. | the 24-h hormonal and metabolic profiles obtained in five non-insulin-dependent diabetics receiving twice daily s.c. injections of the long-acting somatostatin analogue sms 201-995 (50 micrograms) have been compared with those obtained following placebo injection. injections were given 30 min before breakfast and the evening meal. gh secretion was not suppressed by the analogue administered in this manner. despite suppression of serum insulin levels following breakfast and the evening meal, bloo ... | 1986 | 2888547 |
| involution of hyperplastic goitre in the adult male rat. tissue compartment process with early iodide effect: a stereological and biochemical study. | the morphological and functional changes during involution of hyperplastic goitre have been investigated in the adult male rat. male wistar rats received an iodine-deficient diet for 6 months and during the last 2 months received propylthiouracil (ptu, 0.15%). by the end of this treatment (day 0), a hyperplastic goitre was obtained. a normal iodine supply was then given and ptu withdrawn. during the first 8 days of iodine refeeding, the plasma thyrotropin (tsh) remained at a high level (ten time ... | 1987 | 2888235 |
| long latency precedes overt seroconversion in sexually transmitted human-immunodeficiency-virus infection. | signs of latent hiv infection were sought in stored serum samples collected before overt seroconversion, confirmed by enzyme-linked immunosorbent assay (elisa), from 9 subjects with human-immunodeficiency-virus (hiv) infection, in serum from 25 seronegative sexual partners of hiv-seropositive men and from 23 other seronegative, homosexually active men. free hiv antigen and/or low-titre antibodies to recombinant structural (core, env) or non-structural (3' orf, sor, tat) proteins were seen 6-14 m ... | 1987 | 2887886 |
| age-related changes of the function of t cell subsets: predominant defect of the proliferative response in cd8 positive t cell subset in aged persons. | the proportion of cd8 positive cells in the peripheral blood aet-rosette forming t cells from aged persons was significantly reduced than that from young persons. the difference in the proportion between aged and young groups became more significant after proliferative response to a mitogen phytohemagglutinin (pha) or a specific antigen tuberculin active peptide (tap). the purified macrophage-deprived t cells (twp), cd4 (t4) positive cells or cd8 positive cells were prepared from aged or young p ... | 1987 | 2887717 |
| [chronic adult t-cell leukemia with t4 and t8 positive leukemic cells associated with central diabetes insipidus]. | 1987 | 2887677 | |
| interleukin 1 gene expression in adult t cell leukemia. | the adult t cell leukemia (atl) is a t cell neoplasm etiologically associated with human t lymphotropic virus type i (htlv-i) infection. atl cells often abnormally express interleukin 2 (il-2) receptors, and atl patients may show clinical evidence of hypercalcemia, osteolytic bone lesions, or increased bone turnover. whereas interleukin 1 (il-1) is not generally recognized as a product of t cells, this cytokine is capable of both altering il-2 receptor expression and activating osteoclasts. thus ... | 1987 | 2887587 |