Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| cross-linking of t3 (cd3) with t4 (cd4) enhances the proliferation of resting t lymphocytes. | monoclonal antibodies reactive with defined t lymphocyte surface antigens were covalently coupled to protein a-sepharose beads using the bifunctional imidoester, dimethyl pimelimidate. sepharose-immobilized antibody reactive with t3 induced the proliferation of resting t lymphocytes in the presence of either recombinant interleukin 2 or phorbol myristate acetate. when monoclonal antibodies reactive with t3 and t4 were coupled to the same sepharose bead (hereafter designated sepharose (t3:t4)), p ... | 1987 | 3110278 |
| hypothalamic secretion of thyrotropin releasing hormone declines in aging rats. | young and aged male rats were used in experiments to investigate a possible decline in hypothalamic secretion of thyrotropin releasing hormone (trh) to the anterior pituitary of aging mammals. we observed a 66% decrease in basal trh release by incubated rat hypothalami with aging. thyroid hormone-responsive hepatic alpha-glycerophosphate dehydrogenase (gpd) and malic enzyme (me) levels in aged rats did not differ from 5-month-old controls in spite of a significant fall in serum thyroxine (t4) le ... | 1987 | 3110255 |
| a four generation study of familial dysalbuminemic hyperthyroxinemia: diagnosis in the presence of an acquired excess of thyroxine-binding globulin. | we have studied the largest kindred with familial dysalbuminemic hyperthyroxinemia (fdh) thus far reported, comprising thirty-three blood relations in four generations and three of their spouses. our objective was to complement previous evidence concerning the precise mode of inheritance of fdh and to detect any other features of the disorder that had not yet been noted. among the thirty three, there were thirteen patients with fdh, eight males and five females, in all of whom the abnormality ap ... | 1987 | 3110251 |
| lower serum free thyroxine (t4) levels in painless thyroiditis compared with graves' disease despite similar serum total t4 levels. | serum total t4 (t4), total t3 (t3), free t4 (ft4), free t3 (ft3), and t4-binding globulin concentrations and t3 resin uptake values were measured in 17 women with thyrotoxicosis due to painless thyroiditis (pt) and compared with the same parameters in 17 women with thyrotoxicosis due to graves' disease (gd) with similar serum t4 levels. the mean serum t3 resin uptake value and t3, ft4, and ft3 concentrations in the pt patients were significantly lower than those in the gd patients. the mean seru ... | 1987 | 3110204 |
| the effect of free radicals on hepatic 5'-monodeiodination of thyroxine and 3,3',5'-triiodothyronine. | free radicals have been implicated in many pathological processes, including ischemia, inflammation, and malignancy. since a reduction in extrathyroidal outer ring monodeiodination of t4 and rt3 occurs in virtually all systemic illnesses, we have studied the effect of free radicals on iodothyronine (t4 and rt3) 5'-monodeiodinating activity (ma) of liver tissue in vitro. rat liver microsomes or homogenate were preincubated in tris buffer for 30 min with a free radical-generating system (frgs) and ... | 1987 | 3109883 |
| definitive combined modality therapy of carcinoma of the anus. a report of 30 cases including results of salvage therapy in patients with residual disease. | thirty patients with epidermoid carcinoma of the anus, ranging in age from 40 to 89 years, were treated with combined chemotherapy (ct) and radiation therapy (rt) in lieu of abdominoperineal resection. two courses of 5-fu (1000 mg/m2/day x four days) by continuous infusion and mitomycin-c (10-15 mg/m2 iv bolus on day 1 of each course) were given 3 to 4 weeks apart simultaneously, with whole pelvis rt to 4140 to 4500 cgy. twenty-one of 28 patients had t3-t4 primaries and ten had positive nodes (n ... | 1987 | 3109860 |
| decrease of free thyroxin in serum of lactating women. | we measured thyroid hormones and thyroxin-binding proteins in serum from 62 normal lactating and 52 nonlactating women at three months postpartum, and compared these values with those for 42 nonpregnant control women of similar age. mean thyroxin concentrations in the lactating and nonlactating women were significantly (p less than 0.001) lower than that of the nonpregnant controls, but there was no significant difference (p greater than 0.2) in triiodothyronine concentration among these three g ... | 1987 | 3109780 |
| subcutaneous recombinant gamma interferon in cancer patients: toxicity, pharmacokinetics, and immunomodulatory effects. | recombinant gamma interferon (r gamma-ifn) was administered s.c. daily to 26 patients with advanced cancer. patients were assigned to one of six doses: 0.5, 1, 2, 4, 6, or 8 million units (mu)/m2 per d. the major toxicities were an influenza-like syndrome and fever, seen in all patients. dose limiting toxicity occurred in 4 of 4 patients treated at 8 mu/m2. one patient with nodular poorly differentiated lymphocytic lymphoma had a mixed response, and two patients with renal cell cancer have had s ... | 1987 | 3109737 |
| selecting initial therapy for bladder cancer. | progress has been made at both ends of the spectrum of bladder cancer. the introduction and increasing use of effective intravesical agents for both treatment and prophylaxis of tumors limited to the mucosa or lamina propria has reduced the incidence and frequency of subsequent tumors. at the other end of the spectrum--patients with locally extensive bladder cancer--neoadjuvant or initial chemotherapy is producing complete and partial responses. hopefully this will translate into an improvement ... | 1987 | 3109725 |
| the effects of melatonin and hypothyroidism on estradiol and gonadotropin levels in female syrian hamsters. | since melatonin injections administered near the end of the daily photoperiod influence both gonadal and thyroid hormones in the female hamster, the present study was designed to compare the effects of melatonin and hypothyroidism on the reproductive system and to determine whether thyroid status influenced the action of melatonin on the regulation of the hormones of reproduction. the effects of daily melatonin injections were determined in control hamsters, in hamsters rendered hypothyroid with ... | 1987 | 3109508 |
| analysis of human prenatal and postnatal thymocytes with the anti-tac monoclonal antibody and recombinant interleukin-2. | the expression of the interleukin-2 (il-2) receptor on the cell surface membrane of human prenatal and postnatal thymocytes has been studied by flow cytometry. the in vitro responsiveness of these thymocytes to human recombinant il-2 (ril-2) was also studied. prenatal and postnatal thymocytes contained very few tac positive cells. the different t cell antigens t6, t3, t4, t8, t9, t10, 3a1 and t11 were expressed by the first trimester of fetal development. recombinant il-2 alone was able to induc ... | 1987 | 3109082 |
| coronal sections of larynges from radiation-therapy failures: a clinical-pathologic study. | serial coronal sections of 89 wide-field laryngectomies were examined. twenty were specimens obtained from laryngectomies to treat patients for whom primary radiation therapy failed to cure early laryngeal cancer. these specimens were compared to 69 specimens from laryngectomies for t3 and t4 laryngeal cancers. the irradiation-failure group showed a significantly greater invasion of cartilage and extension into subglottic areas. the extension of tumors along blood vessels and mucous glands appea ... | 1986 | 3108762 |
| effects of six weeks' neuroleptic treatment on the pituitary-thyroid axis in schizophrenic patients. | in order to investigate the effects of 6 weeks' neuroleptic treatment on the pituitary-thyroid axis in 25 male schizophrenic patients, and the diurnal variation in the thyrotropin (tsh) and prolactin (prl) responses to thyrotropin-releasing hormone (trh) in these patients, the trh stimulation test was performed in each of them at 14.00 and 24.00 h of the same day, both before and after 6 weeks' treatment with neuroleptics (chlorpromazine or fluspirilene). also, serum thyroxine (t4), in vitro rad ... | 1986 | 3108695 |
| human t cells targeted with anti-t3 cross-linked to antitumor antibody prevent tumor growth in nude mice. | human peripheral blood t cells were tested for the ability to prevent tumor growth in nude mice when targeted with anti-t3 cross-linked to antitumor antibodies. ls174t human colon adenocarcinoma cells were mixed with human pbl coated either with anti-t3 (fab) cross-linked to 315f6 (fab) (an antitumor monoclonal antibody) or with no antibody, and were injected subcutaneously into nude mice. tumor growth was totally inhibited at effector to target (e:t) ratios of 7.0:1 and 2.1:1, and was partially ... | 1987 | 3108382 |
| lymphokine activation of t4+ t lymphocytes and monocytes. | the function of the t4 antigen, a marker for a differentiated t cell subset, is not well understood. our previous observation that a chemoattractant human lymphokine, lymphocyte chemoattractant factor (lcf), which selectively induces motile responses in unactivated t4+ lymphocytes, led us to investigate whether lcf could also induce t4+ cell activation. because lcf acts selectively on t4+ cells, we next determined whether the t4 antigen has a function in this lcf-induced cellular activation. a t ... | 1987 | 3108375 |
| autoimmune effector cells. ix. inhibition of adoptive transfer of autoimmune encephalomyelitis with a monoclonal antibody specific for interleukin 2 receptors. | this study was conducted to determine whether a monoclonal antibody (mab) specific for rat interleukin 2 receptors (il 2r) inhibits the activation of effector t cells that adoptively transfer experimental allergic encephalomyelitis (eae). mab ox 39 appears to be specific for il 2r because it binds to concanavalin a-activated, but not resting, rat lymphocytes and inhibits mitogen- and il 2-induced proliferation of rat spleen cells. moreover, this mab inhibits the in vitro activation of effector c ... | 1987 | 3108373 |
| elevation of serum igg levels and normalization of t4/t8 ratio after hepatitis in a patient with common variable hypogammaglobulinemia. | acute hepatitis infection developed in a 47-year-old male patient with common variable hypogammaglobulinemia as a consequence of plasma transfusion therapy. coincident with increases in serum transaminase activities indicative of acute hepatitis, serum igg levels continued to rise to 506 mg/dl. when plasma replacement therapy was stopped, a transient decline in igg level (to 371 mg/dl) was produced, followed by a sharp increase in igg to 607 mg/dl. during this period, the patient's t4/t8 ratio, ... | 1987 | 3108350 |
| pituitary-hypothalamic response in adolescents with growth failure due to fear of obesity. | nine patients (4f, 5m) aged 12-17 years with "fear of obesity" were studied with a sequential stimulation test utilizing insulin, lrh, trh, and l-dopa. the comparative groups were nine female with classic anorexia nervosa, five males with undifferentiated nutritional dwarfing, and nine children (1f, 8m) with constitutional growth delay. the serum tsh, glucose, cortisol, somatotropin, prolactin, lh, and fsh were sampled periodically over 2 hours. basal t3, t4, transferrin, and somatomedin-c level ... | 1987 | 3108348 |
| heat treatment for endocrinological investigations on plasma positive for human immunodeficiency virus (hiv). | the effects of heat treatment of serum samples on the hormone analyses used in this laboratory were studied. total t4, testosterone, progesterone, and growth hormone were not systematically affected by heat treatment over the whole range of analyte concentrations studied; for thyroid stimulating hormone, no effect was noted on serum samples with concentrations of less than 10 mu/l. significant changes occurred in total t3, cortisol, follicle stimulating hormone, luteinizing hormone, and prolacti ... | 1987 | 3108328 |
| changes in lh and fsh serum pattern following l-t4 withdrawal in l-t4 substituted hypothyroids. | 1987 | 3108132 | |
| prolactin in cluster headache: diurnal secretion, response to thyrotropin-releasing hormone, and relation to sex steroids and gonadotropins. | the diurnal rhythmicity of serum prolactin (prl) and the prl and thyrotropin (tsh) response to thyrotropin-releasing hormone (trh) were studied in 31 cluster headache patients (4 chronic cases) and 14 healthy controls. sixteen of the patients were studied both during clinical remission and headache periods. in males the nocturnal prl peak was blunted during remissions as compared with that in cluster periods and that in control individuals. the 24-h mean prl levels were lower during remission an ... | 1987 | 3107837 |
| cytochemistry of n-acetyl-beta-glucosaminidase in normal and leukemic t cells. | a cytochemical study of the n-acetyl-beta-glucosaminidase (nabg) activity in normal and leukemic t cells was carried out to ascertain any relationships between cytochemical reactivity and membrane phenotype. under normal conditions, most t4-positive cells, defined on the basis of monoclonal antibodies and immunogold, were characterized by focal reactivity. in chronic t lymphoproliferative disorders, the reaction product of t4-positive cells consisted of a single coarse granule, while t8-positive ... | 1987 | 3107326 |
| serum free thyroid hormones in different degrees of hypothyroidism and in euthyroid autoimmune thyroiditis. | serum total and free t4 and t3, thyroxine-binding globulin (tbg) and tsh, basal and 20, 30 and 60 min after trh (200 micrograms, iv), were evaluated in 125 hypothyroid patients (38 with severe, 23 with mild, and 64 with subclinical hypothyroidism), in 35 euthyroid subjects with autoimmune thyroiditis, and in 51 healthy controls. t4/tbg and t3/tbg ratios were also calculated. a significant decrease in all indices of thyroid function except for t3 occurred simultaneously with a significant increas ... | 1987 | 3107297 |
| human immunodeficiency virus infection of monocytic and t-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester. | the monocytic leukemic cell line u937 can be infected with human immunodeficiency virus type 1 (hiv-1) to become permanently infected virus producers. uninfected u937 cells express t4 (cd4) antigen and form syncytia when mixed with hiv-1 producing cells. anti-t4 monoclonal antibodies block syncytium formation indicating that the hiv-1 receptors on u937 cells include t4 antigen. the promyelocytic leukemic cell line hl60, while expressing only low amounts of surface t4 and not forming syncytia on ... | 1987 | 3107214 |
| effects of microwaves on three different strains of rats. | confounding factors influencing the sensitivity of biological indicators of microwave exposure--lethality, colonic temperature (tco), decreased body mass (dw), corticosterone (cs), thyrotropin (tsh), thyroxine (t4), free thyroxine (ft4), and prolactin (prl) concentration--were studied in long-evans (le), wistar-kyoto (wky), and spontaneous hypertensive (shr) rats. the microwave signal was 2.45 ghz amplitude modulated at 120 hz. test power density ranged from 1 to 50 mw/cm2 for 2 h. in contrast t ... | 1987 | 3107046 |
| hyperthyroidism and high serum levels of tsh associated with pituitary tumour. | we report a 28-year-old male with persistent clinical and laboratory findings of hyperthyroidism associated with marked elevated serum levels of tsh and no response to trh despite hemithyroidectomy and subsequent antithyroid drug therapy two years previous to admission to our hospital. subsequent skull x-rays, ct scans and angiographic findings demonstrated the presence of a pituitary tumour. after operation and radiation therapy t3, t4 and tsh levels returned to normal values. seven years later ... | 1987 | 3106846 |
| [the hypothalamo-hypophyseal thyroid axis, plasma protein concentrations and the hypophyseo-gonadal axis in low t3 syndrome following acute myocardial infarct]. | in patients with severely acute diseases, a special relationship of thyroidal hormones with decreased t3 and increased rt3 levels is known, the so-called low t3 syndrome. the aim of this study was to elucidate the involvement of the hypothalamo-pituitary thyroid axis, the pituitary-gonadal axis, the altered hepatic function, the plasma proteins in the low t3 syndrome, and the evaluation of these parameters for prognosis in patients with acute myocardial infarction. thirty-one patients (29 male, ... | 1987 | 3106708 |
| variability of l-thyroxine replacement dose in elderly patients with primary hypothyroidism. | sixty-three elderly patients (aged more than 65 years) who manifested primary hypothyroidism during 4 1/2 years from september 1980 to march 1985 were studied. patients were divided into two groups depending on the presence or absence of chronic associated disorder at the time of diagnosis. patients in the sick group were required to consume several medications throughout the study period in addition to l-thyroxine for their total therapeutic management. subjects in the healthy group required l- ... | 1987 | 3106558 |
| reversal of advanced murine lupus in nzb/nzw f1 mice by treatment with monoclonal antibody to l3t4. | murine lupus in nzb/nzw f1 (b/w) mice can be prevented by weekly treatment with monoclonal antibodies (mab) to l3t4 (on "helper/inducer" t cells) if treatment is begun prior to the onset of clinical illness. to determine whether anti-l3t4 could reverse as well as prevent murine lupus, we monitored a cohort of 30 b/w females until age 7 mo, when severe autoimmune disease was established, and then we examined the effects of weekly treatment with mab to l3t4. the rate of target cell clearance by ma ... | 1987 | 3106478 |
| human mucosal cytotoxic effector cells. | human intestinal lamina propria mononuclear cells have been shown to mediate mitogen-induced cellular cytotoxicity, antibody-dependent cellular cytotoxicity, and lymphokine activated killer cell function. however, although natural killer cells have been demonstrated in the gut mucosa of rodents, recent reports found little or no spontaneous cytotoxic activity in the lamina propria of the human gut. using the natural killer cell-related monoclonal antibody nkh-1, which has not previously been app ... | 1987 | 3106129 |
| childhood lead toxicity and impaired release of thyrotropin-stimulating hormone. | decreased stature of children is epidemiologically associated with increased blood lead independent of multiple socioeconomic and nutritional variables. since endocrine dysfunction occurs in adult lead workers, we studied two girls, 2 years of age, before and after calcium disodium edetate chelation for blood leads (pbb) of 19-72 micrograms/dl. the height of both children had crossed from the 50th to below the 10th percentile during the course of chronic lead toxicity. basal free t4, t4, t3, cor ... | 1987 | 3106028 |
| thyroid hormone-binding proteins in plasma facilitate uniform distribution of thyroxine within tissues: a perfused rat liver study. | we used autoradiography to test the hypothesis that a major function of thyroid hormone-binding proteins in plasma is to ensure uniform distribution of thyroid hormones among cells of a given tissue. the distribution of [125i]t4 within rat hepatic lobules was determined after its single pass perfusion through the portal vein in solutions containing or lacking thyroid hormone-binding proteins. these proteins included thyroid hormone-binding globulin, thyroid hormone-binding prealbumin, and albumi ... | 1987 | 3106010 |
| free t4 measurement is preferred to the t4 test for thyroid evaluation in lithium treated patients. | free t4 (ft4) measurement provides a more sensitive test of thyroid function than the commonly used t4. recent commercial development of ft4 kit assays has made ft4 assessment widely available. evaluation of the ft4 amerlex kit in 26 lithium-treated patients illustrates its utility as a sensitive laboratory test of thyroid function in this group of patients. this finding together with ft4's known superiority over t4 in identifying thyroid dysfunction suggests that ft4 should replace t4 estimatio ... | 1987 | 3105860 |
| immune status of greek patients with beta-thalassemia major negative for anti-hiv. | patients with thalassemia who receive multiple blood transfusions are at risk for the acquired immunodeficiency syndrome. peripheral blood lymphocyte subpopulations were studied in 22 multitransfused thalassemic patients; 10 patients were without splenectomy and 12 were studied after splenectomy. both groups were negative for anti-hiv. four additional patients who were found positive for anti-hiv and ten healthy controls were also included in this study. patients without splenectomy compared to ... | 1987 | 3105626 |
| [research related to hormones in nagase analbuminemic rats]. | the levels of hormones in the anterior pituitary gland and serum in nagase analbuminemic rats (nar) were examined. for the anterior pituitary gland, the contents of prolactin, tsh, gh, lh and fsh in male nar were lower than those of normal rats. in female nar, prolactin and tsh levels were also lower than those in normal rats, whereas lh, fsh and gh were unchanged. in serum, the concentrations of tsh, t3, t4, estradiol, testosterone and prolactin (female only) were examined. the serum prolactin ... | 1987 | 3105460 |
| postmortem endocrine levels in the vitreous humor. | the vitreous humor and sera from 51 autopsy cases were assayed for progesterone, estradiol, thyroxine, triiodothyronine, tsh, fsh, lh and prolactin. the results indicate that the blood retinal barrier has unique properties of its own. all hormones were measurable in the sera. progesterone, estradiol, t3 and t4 were not detected despite their lipid solubility and their small molecular size while the larger glycoprotein hormones were easily measureable. | 1986 | 3105417 |
| dog erythrocyte rosette-forming lymphocyte: blockage by okt11 monoclonal antibody. | human peripheral blood mononuclear cells (pbm) were separated into sheep erythrocyte rosette-forming (es+) and non es+ cells by the ficoll-hypaque gradient sedimentation method. thirty-eight percent of the es+ cells formed rosettes with dog erythrocytes and were designated as es+ed+ cells. the remaining es+ cells were designated as es+ed- cells. only a few non es+ cells formed rosettes with dog erythrocytes. among es+ed+ cells, t4 antigen-positive cells were observed approximately 1.7 times as o ... | 1987 | 3105252 |
| thyroid hormone reserve in asymptomatic autoimmune thyroiditis. | basal (b) and peak (p) serum levels of thyroxine (t4), free thyroxine (ft4), triiodothyronine (t3), free triiodothyronine (ft3), and tsh were measured before and after oral trh (40 mg) administration in 79 subjects affected with asymptomatic autoimmune thyroiditis (aat) and in 69 normal subjects. the area under the curve (auc) and peak values of t4, ft4, t3 and ft3 were considered as parameters of thyroid hormone reserve. intrathyroidal iodine (iti) was measured by the x-ray fluorescence method. ... | 1987 | 3105206 |
| t4+ cells can initiate human graft-versus-host disease. | 1987 | 3105126 | |
| grades 1 and 2 hypothyroidism in a state mental hospital: risk factors and clinical findings. | thirty-six chronically psychotic patients (nine men and 27 women, mean age 56.7 +/- s.d. 13.4 years) were found to have elevated thyroid stimulating hormone (tsh) levels during review of thyroid function screening tests of 1150 patients over a 15 month period in a 700 bed state mental hospital. this study population of 36 patients was more likely to be female and older than the general hospital population. the spectrum and frequency of psychiatric diagnoses included dementia (3); schizoaffective ... | 1986 | 3104944 |
| single cell studies on the immunological marker profile of plasmacytoid t-zone cells. | plasmacytoid t cells (ptc) are known to home to thymic (t) zones in human lymph nodes and are characterized by their abundant, concentrically layered, rough endoplasmic reticulum. these cells have been found in reactive and neoplastic conditions. three cases of ptc lymphomas have so far been reported. all of them were complicated by a myelomonocytic leukemia leading to the assumption of a functional relationship between ptc and the myeloid system. the immunologic phenotype of ptc, as revealed on ... | 1987 | 3104684 |
| effect of hypometabolism on cell injury. | rats were given galactosamine 1 g/kg i.p. pretreatment with propylthiouracil 14 days prior to intoxication and surgical thyroidectomy 10 days prior to intoxication significantly reduced the elevation of sgot and gldh activities and protected against hepatocellular necrosis 28 h after intoxication. t3 and t4 levels decreased significantly within the first 2 days in patients with acute myocardial infarction, while rt3 levels were found to be elevated within this period. trh and tsh decreased durin ... | 1986 | 3104654 |
| enzymatic synthesis and some properties of a model primitive trna. | a model primitive trna with the nucleotide sequence ggccaaaaaaaggccp was synthesized using t4 rna ligase. the nucleotide sequence of this newly synthesized oligonucleotide was confirmed by ladder analysis of several enzymatic digestion products. the secondary structure of the oligonucleotide was examined by comparison of the products of its digestion by single- and double-strand-specific nucleases with those of the digestion of the intermediate oligonucleotide ggccaaaaaaaoh. the results indicate ... | 1986 | 3104604 |
| heterogeneous expression of leu3/t4 antigen on cord t cells. | 1987 | 3104514 | |
| t cell surface markers expression by immature human thymocytes in in vitro culture: role of ia+ accessory cells. | previous studies have indicated that the human thymus is composed of several discrete compartments. cortical thymocytes are reactive with the monoclonal antibody anti-t6, whereas most medullary cells, unreactive with anti-t6, stain brightly with anti-t3 antibody, which defines mature t cell populations. by using an indirect immune rosette method, we isolated the minor thymocyte population (1 to 2% of all thymocytes) lacking both t3 and t6 but expressing t11 antigens. these cells could be maintai ... | 1987 | 3104465 |
| il 1 expression in a clone of human t cells. | three human t cell clones, all of which are t3+, t4+, t8-, and t11+, were examined for il 1 production. two clones were found to express readily detectable, membrane-bound il 1 activity upon stimulation with okt3 antibody, ril 2, and pma. northern blot analysis of rna from one of the clones shows that cells can be induced to express the genes for both il 1 alpha and il 1 beta. furthermore, the pattern of expression in response to different stimuli suggests that the genes for il 1 alpha and il 1 ... | 1987 | 3104451 |
| influence of hbv replication and delta agent superinfection on t cell subsets and killer (leu 7+) in chronic hepatitis b virus infection. | peripheral blood t-lymphocyte subsets and cells reacting for leu 7 antigen, which identifies a subset of killer and natural killer cells, have been examined in 32 patients chronically infected by the hepatitis b or d viruses (hbv, hdv) and in 28 normal subjects. the t8+ lymphocytes were increased and the t4/t8 ratio was decreased in patients with hbv replication (identified by the presence of hbcag in liver and hbv-dna in serum) and in patients with hdv infection (hdag in liver). these patients ... | 1986 | 3104445 |
| thyroxine kinetics in nonthyroidal illnesses. | free t4 estimates by equilibrium dialysis appear to reflect serum free t4 levels in vivo in patients with nonthyroidal illnesses. however, patients with either elevated or modestly reduced free t4 values appear to be clinically euthyroid and have relatively normal free t4 availability to tissues as judged by the normal production rates of reverse t3 from t4, and by the minimally altered tsh status. thus, increased or modestly reduced serum free t4 levels by equilibrium dialysis in patients with ... | 1986 | 3104439 |
| feasibility of non-surgical definitive management of anal canal carcinoma. | the management of anal canal carcinoma has evolved over the last decade, with the combination of radiotherapy (rt) and chemotherapy (ct) offering a definitive alternative to surgery or rt alone. twenty-two patients with basaloid/cloacogenic/squamous cell carcinoma of the anal (13 with t3-t4 lesions), were treated with synchronous rt (30.00 to 45.00 gy in 3 1/2 to 5 weeks) and ct x 2 courses (mitomycin c 15 mg/m2 i.v. bolus + 96 hours 5fu infusion). this regimen differed from the conventional nig ... | 1987 | 3104242 |
| abnormalities in pituitary thyroid axis function tests in patients with paroxysmal supraventricular arrhythmias. | the study was carried out on 60 consecutive patients (23 males and 37 females) aged between 20 and 83 years (means +/- sd, 40.7 +/- 16) who arrived at our cardiologic unit with paroxysmal supraventricular arrhythmias (psva) including junctional paroxysmal tachycardia (n = 32), atrial fibrillation (n = 13), atrial flutter (n = 1), premature beats (n = 13) and with no obvious cardiovascular causes. serum thyroxine and triiodothyronine were normal in all patients and thyroid scintiscan revealed nor ... | 1987 | 3104185 |
| [studies on cytosol thyroid hormone binding proteins in the rat liver: part iii. partial purification and binding characteristics of thyroxine-binding protein in hypothyroid rat liver cytosol and serum]. | cytosolic thyroxine-binding protein (ct4bp) was partially purified from rat liver cytosol obtained 10 days after thyroidectomy using sephadex g-200 gel filtration, and its binding characteristics were analyzed in displacement experiments using a charcoal binding method to separate bound and free hormones. serum t4-binding proteins were also partially purified, and their binding characteristics were similarly determined. sephadex g-200 gel filtration of liver cytosol from thyroidectomized rats re ... | 1987 | 3104103 |
| inherited thyroxine-binding globulin excess. study in a kindred. | a three-generation family with hereditary high thyroxine-binding globulin (tbg) serum levels has been studied. all patients were clinically euthyroid and did not have a goiter. four females of the eleven members of the kindred had elevated tbg (range: 34-56 micrograms/ml), total thyroxine (t4) and total triiodothyronine (t3) levels, but normal free t4 (ft4) and normal response of thyroid stimulating hormone (tsh) to intravenous application of thyrotropin-releasing hormone (trh). microheterogenei ... | 1986 | 3104070 |
| involvement of the cd4 molecule in a post-activation event on t cell proliferation. | a monoclonal antibody (mab) directed to a human leukocyte 55-kda cell surface molecule with identical cellular distribution and biochemical properties to the cd4 was able to inhibit t cell proliferation induced either in a mixed lymphocyte culture or by activation with mab anti-cd3, anti-cd2 or phytohemagglutinin. the inhibitory effect of anti-cd4 was observed in the absence of monocytes and was directly exerted on t4+ cells. this effect on cellular proliferation appears to be due to an inhibiti ... | 1987 | 3104060 |
| thyroid hormone response to thyrotrophin releasing hormone (trh) in the sex-linked dwarf chicken. | the effect of an injection of thyrotrophin releasing hormone (trh) on plasma levels of thyroid hormones was studied in dwarf and normal rhode island red chickens with similar genotypes other than for the sex-linked dwarf gene dw. the sex-linked dwarf chickens had different plasma iodothyronine levels from control normal chickens: high thyroxine (t4), low triiodothyronine (t3) and similar reverse t3 (rt3) levels. the injection of trh (10 micrograms/kg) in 5-day- and 5-week-old normal chickens inc ... | 1986 | 3104021 |
| effect of thyroxine-binding globulin (tbg) on thyroxine (t4) uptake by human peripheral mononuclear cells: evidence of tbg-dependent uptake of t4. | the effect of sialylated tbg and desialylated tbg on thyroxine (t4) uptake by human peripheral mononuclear cells was investigated in vitro. [125i]-t4 uptake was observed when the cells were incubated with free [125i]-t4. the uptake was inhibited in a concentration dependent manner when tbg was added. during the incubation, [125i]-t4 binding to tbg was observed. [125i]-t4 incorporation into cells was also observed when the cells were incubated with [125i]-t4-sialylated tbg or with [125i]-t4-desia ... | 1986 | 3104020 |
| aspects of thyroid function during use of norplant implants. | plasma thyroxin (t4), triiodothyronine (t3), t3-uptake and thyroid stimulating hormone (tsh) were measured in 18 women using norplant implants or norplant-2 implants for six months. free t4-index and free t3-index were also calculated. all women had used non-hormonal contraceptives before insertion of the implants. t4 decreased and t3-uptake increased, indicating a lower level of thyroid binding proteins during treatment. free t4-index remained unchanged, indicating that the free concentration o ... | 1986 | 3103979 |
| glyburide does not alter thyroid function. | goiter and hypothyroidism have been reported as side effects of sulfonylurea therapy. to test the effects of glyburide, a new generation sulfonylurea drug, on thyroid function, we studied 15 male type 2 diabetic patients before and after 6 weeks of treatment with this drug, and we repeated the studies on 9 of these patients who remained on the drug for at least 24 weeks. all hypoglycemic agents were discontinued for 1 week before the study. patients had a baseline thyroid examination, serum t4, ... | 1986 | 3103970 |
| t-cell prolymphocytic leukemia (t-pll) with unique surface phenotype. | leukemic cells of a 19 year old patient with prolymphocytic leukemia of t-cell type (t-pll) were characterized by surface markers and immunologic functions. phenotypic analysis using a large panel of monoclonal antibodies corresponding to the clusters (cd) of differentiation antigens established on the leukocyte typing workshops i and ii revealed a unique t-cell phenotype not yet reported in the literature: cd1 (t6)-, cd2 (t11)+, cd3 (t3)+, cd4 (t4)-, cd5 (t1)-, cd6 (t411)+, cd7 (leu9)+, cd8 (t8 ... | 1987 | 3103723 |
| prevalence of antibodies to aids-associated retrovirus in in- and out-patients in japan. | serum specimens from 252 recipients of factor viii and/or factor ix (237 hemophiliacs and 15 nonhemophiliacs), 99 blood transfusion recipients, 269 chronic diseases, and 366 healthy subjects (included blood donors, hospital personnel and family members of hemophiliacs) were tested for reactivity to lymphadenopathy-associated virus/t-lymphotropic retrovirus type iii (lav/htlv-iii) by elisa test kit (abbott), and the presence of the antibodies to lav/htlv-iii was confirmed by indirect immunofluore ... | 1986 | 3103640 |
| clinical, immunological, and virological aspects in japanese hemophiliacs and aids patients. | to date, 16 cases of aids have been officially reported in japan: 8 of them were hemophiliacs and the others were male homosexuals. we had two hemophiliacs with aids, and describe these cases in this paper. one was a 48-year-old man with hemophilia b and the other was a 62-year-old man with hemophilia a. both had arc symptoms before developing overt and fatal opportunistic infections, candidiasis and a combination of atypical mycobacteriosis and aspergillosis. impairment of cellular immunity suc ... | 1986 | 3103637 |
| susceptibility to infection by the human immunodeficiency virus (hiv) correlates with t4 expression in a parental monocytoid cell line and its subclones. | the monocytoid tumor cell line u-937 and five derived subclones were infected with the htlv-iiib isolate of the human immunodeficiency virus (hiv). susceptibility to infection and sensitivity to the cytopathic effects correlated with the expression of the t4 antigen on the cell surface. on the basis of these characteristics the lines could be divided into three groups. less than 10% t4 positive cells were present in the parental line and clone 4; hence productive infection could only be establis ... | 1987 | 3103330 |
| evidence for neoplastic cell differentiation in mediastinal t lymphoblastic lymphoma. | immunostaining of frozen sections from a mediastinal t lymphoblastic lymphoma (t-ll) revealed the existence of two neoplastic cell populations characterized by different degrees of maturation. several large nodules of 3a1+/t11+/t9+ t6-/t4-/t8-/t3- lymphoid cells, resembling normal early thymocytes, were surrounded by 3a1+/t11+/t9+/t6+/t4+/t8+/t3- cells resembling normal cortical thymocytes. the junctional area between early and cortical lymphocytes was occupied by numerous leu-m3+/pam-1+/dr+ ret ... | 1987 | 3103325 |
| [congenital hypothyroidism. current viewpoints and developments]. | since 1978 neonatal screening on congenital hypothyroidism (cht) is performed in the netherlands. a combined t4 and tsh determination is used. this creates the possibility to detect secondary and tertiary hypothyroidism. the number of false-positive cases is relatively high. this number decreases by adjusting the method of screening. recent studies show a cht incidence of 1:2100 newborns. in about 25% of these cases the cht appears to be transient. proceeding from the screening on cht several in ... | 1986 | 3103255 |
| interference of dimethyl alpha-(dimethoxyphosphinyl) p-chlorobenzyl phosphate (sr-202) in thyroid hormone metabolism: evidence of inhibition of monodeiodination. | sr-202 is a non-iodinated potential lipid-altering agent. when administered (100 mg) three times per day for 3 days to six euthyroid subjects it was associated with a 30 +/- 3% (mean +/- s.e.m.) fall in 3,3',5-triiodothyronine (t3) (p less than 0.001), a reciprocal 104 +/- 14% rise in 3,3',5'-tri-iodothyronine (reverse t3, rt3) (p less than 0.01), and a 37 +/- 7% rise in thyroxine (t4) (p less than 0.001). basal and trh-stimulated tsh did not change. these results suggested that sr-202 was actin ... | 1987 | 3102663 |
| accessory cell independent proliferation of human t4 cells stimulated by immobilized monoclonal antibodies to cd3. | the capacity of the monoclonal antibodies (mab) 64.1 and okt3 directed at cd3 molecules to induce t4 cell proliferation and interleukin 2 (il 2) production was examined. each was tested in soluble form or was immobilized by adhering it to the wells of plastic microtiter wells. soluble anti-cd3 did not induce proliferation of accessory cell (ac)-depleted t4 cells. in contrast, immobilized anti-cd3 induced t4 cell il 2 production and proliferation in the complete absence of ac. when t4 cells were ... | 1987 | 3102594 |
| assessment of sensitive thyrotropin assays for an expanded role in thyroid function testing: proposed criteria for analytic performance and clinical utility. | assays capable of detecting subnormal serum tsh concentrations can permit the prediction of response to trh and the detection of hyperthyroidism. five performance criteria for evaluating the eligibility of tsh assays for these new roles are proposed. criterion 1 requires a less than 1% overlap between the variation of the lower normal value and the assay detection limit. criteria 2 and 3 require subnormal basal tsh values in 95% of patients with subnormal trh response, and detectable basal tsh v ... | 1987 | 3102536 |
| the trh test in rats with chronic chagas disease. | trh was studied in rats with chronic chagas disease. it was found an increased secretion of tsh 60 minutes after intraperitoneal injection of the hypothalamic hormone. t3 and t4 were also decreased in basal conditions. this may indicate a primary hypothyroidism. | 1986 | 3102263 |
| function of the lfa-1 and t4 molecules in the direct activation of resting human b lymphocytes by t lymphocytes. | activated t lymphocytes can provide all of the signals necessary to induce the proliferation of resting b lymphocytes. the activation signal is presumably initiated through direct t-b lymphocyte contact. the role of the leukocyte function antigen-1 (lfa-1) and t4 molecules in the activation of purified, small b lymphocytes by mitomycin c-treated t lymphocytes was examined by using monoclonal antibodies that react with and inhibit the function of these molecules. anti-lfa-1 antibody binding signi ... | 1986 | 3102246 |
| characterization of the t3+t4+t8+ thymocyte intermediate in vitro. | sensitive two-color fluorescence staining and cell-sorting techniques were used to isolate a t4+t8+ thymocyte subpopulation with high t3 density from human thymocyte cultures. previously, this population was shown to give rise to both t4+t8- and t8+t4- thymocytes. in the present study, this t3+t4+t8 population was shown to be functionally as well as phenotypically distinct from either t8+t4- cells or t4+t8- cells present in the same culture. the t3+t4+t8+ cell had intermediate cytotoxic capaciti ... | 1987 | 3102076 |
| abnormalities of lymphocyte subsets and anti-lav/htlv-iii status in greek hemophiliacs. | peripheral blood lymphocyte subsets and the incidence of lav/htlv-iii antibodies were studied in 63 patients with hemophilia a who had been transfused with a low dose regimen of commercial (u.s.a.) factor viii concentrates. five patients with hemophilia b were also included in this study. in hemophilia a patients a significant reduction in the percentage and absolute numbers of t4+ cells and of the t4/t8 ratio and a significant increase in the percentage of t8+ and leu-7+ cells were observed. th ... | 1986 | 3101712 |
| hypothyroxinemia in cardiac arrest. | thyroid function was evaluated in cardiac arrest (ca), a condition associated with marked activation of the pituitary-adrenal axis. blood samples were obtained in 24 patients immediately after diagnosis of ca and again ten minutes later. samples were also obtained from 22 patients admitted consecutively to the intensive care unit (icu). abnormalities of thyroid indexes among patients on the icu who had not experienced ca were low triiodothyronine (t3) in 45%, low thyroxine (t4) in 32%, low free ... | 1987 | 3101625 |
| natural history of acquired immunodeficiency syndrome in hemophilic patients. | during the 5-year period from 1981 to 1985, we have observed 8 cases of acquired immunodeficiency syndrome (aids) among our 85 patients with hemophilia a. thus, the prevalence of aids with hemophilia a is 9.4% in our patient population. by utilizing stored serum or plasma samples dating back to 1978, antibody against htlv-iii was detected in all 8 cases with aids. based on the time interval from the appearance of antibody to htlv-iii to the diagnosis of aids in these patients, the incubation per ... | 1987 | 3101490 |
| serum concentrations of thyrotropin, thyroxine, triiodothyronine and thyroxine binding globulin in female endurance runners and joggers. | the effects of endurance training and season on the function of the anterior pituitary-thyroid axis were studied in 18 female runners and their 12 controls, and in 13 joggers and their 11 controls in northern finland, with a large seasonal difference in environmental factors. the serum concentrations of thyrotropin (tsh), thyroxine (t4), free thyroxine (ft4), triiodothyronine (t3), thyroxine binding globulin (tbg) and oestradiol (e2) were measured during one menstrual cycle in the light training ... | 1987 | 3101339 |
| the pituitary tsh response to trh is inversely related to the plasma tsh concentration and directly related to the pituitary tsh content during hypothyroidism in the rat. | we studied the effects of degree and duration of hypothyroidism on the pituitary tsh concentration and the pituitary tsh secretory response to trh. varying degrees of hypothyroidism were achieved in thyroparathyroidectomized rats (thyrex) by continuous sc infusion of t3 (0.2, 0.3, 0.4, or 0.5 microgram/100 g x day) or t4 (0.6, 1.2, or 1.8 microgram/100 g x day). while t3 was more potent than t4, both resulted in a dose-dependent suppression of the post-thyroidectomy rise in tsh. after 7 or 14 da ... | 1987 | 3101338 |
| immunohistological analysis of the lymphoid infiltrate in cutaneous malignant melanomas. | the immunological phenotypes of the lymphoid cells in 39 cutaneous malignant melanomas have been investigated by staining cryostat sections with a panel of 20 monoclonal antibodies against lymphoid cells and their subsets. staining was performed by the alkaline phosphatase: anti-alkaline phosphatase (apaap) method in which the substrate label (red) is easily distinguishable from melanin. the lymphoid infiltrates had an essentially identical composition in all cases, consisting of t-lymphocytes a ... | 1987 | 3101284 |
| [levels of thyroxine, beta carotene and vitamin a during successful and unsuccessful insemination of heifers]. | we studied the concentrations of thyroxine (t4), beta-carotene and vitamin a (vit. a) on the day (zero-th day) of the first successful and unsuccessful insemination of 63 heifers that were administered feed rations balanced according to the czechoslovak standard csn 46,7070, housed all the year round, inseminated at uniform time (8:00-9:00 a. m.) and with blood samplings at uniform time (10:00-12:00 a. m.). in the repeat-breeder heifers during the first insemination the above parameters were det ... | 1986 | 3101266 |
| the results of a series of 963 patients with transitional cell carcinoma of the urinary bladder primarily treated by radical megavoltage x-ray therapy. | the results are reported of a large series of patients with transitional cell cancer of the bladder, treated in edinburgh between 1971 and 1982. analysis of pre-treatment characteristics for patients with transitional cell bladder cancer showed that tumour category was significantly associated with grade and tumour size. complete local tumour regression at follow-up cystoscopy was achieved in 45.9% of patients who completed radical megavoltage x-ray therapy. patients with grade 2 or 3 cancer, a ... | 1986 | 3101140 |
| [evaluation of the parameters used in monitoring hypothyroid patients treated with l-thyroxine]. | hormonal and clinical data on 38 tests performed in 7 hypothyroid patients given substitutive treatment with l-thyroxin were analysed. the aim of the survey was to assess the dependability of the various parameters used to estimate dose adequacy in substitutive treatment. examination of individual cases revealed that overdoses of thyroxin increased t4 to above normal limits without increases in t3, ft3, ft4 or hypophyseal suppression. chronological discrepancies between clinical data and normal ... | 1986 | 3101002 |
| [radioimmunological and immunological follow-up of toxic goiter remission following radiotherapy and thyroidectomy]. | the paper is concerned with a multimodality approach to the assessment of clinical remission in 42 patients after radical therapy of toxic goiter. t4, t3, sigma tsh, delta tsh were determined in the thyrotropin releasing hormone stimulation test (trh-test); some immunological indices (rfcc, rfcn, rfc1, a stimulation index [si] lbtr, a migration index [mi] in the lmit and serum immunoglobulins) were also investigated. the abnormal trh-test was revealed in 2/3 of the patients (the hypo-trh-test in ... | 1987 | 3100903 |
| interleukin-2 (il-2) and its receptor. | the interleukin-2 (il-2) receptor system which is responsible for t-cell cycle progression is a unique hormone-receptor system in that both the ligand and the receptor need to be induced. in the present article i will review the biological and molecular characteristics of il-2 and its receptor, as well as the differential triggering and growth requirements that l3t4+ (t4+) helper and lyt-2+ (t8+) cytotoxic/suppressor t-cells display to respond. the various mechanisms of regulation operating to r ... | 1986 | 3100883 |
| cross reactivity of a monoclonal pan t-cell antibody (anti-leu 4) with prostate epithelium. | cross reactions between monoclonal t-cell antibodies and non-lymphoid tissues have rarely been reported. in this study 28 samples of prostatic tissue obtained at the time of autopsy or surgery, two samples of metastatic prostatic carcinoma and a series of other tumours were snap frozen and sections reacted with a series of monoclonal antibodies directed against the following antigens: leu 1, leu 4, t3, t8, t4, t11 and b4. reactions were detected with an indirect immunofluorescent method. in 10 o ... | 1987 | 3100824 |
| clonal analysis of t lymphocytes infiltrating the thyroid gland in hashimoto's thyroiditis. | t cells isolated from thyroid tissue and peripheral blood of 2 patients with hashimoto's thyroiditis were studied by a high cloning efficiency microculture technique. clonal efficiencies of 37 and 24% were obtained from thyroid-derived t cell cultures, while 40 and 90% efficiencies resulted from peripheral-blood-derived cultures. a prevalence of t4-/t8+ t cell clones were found in thyroid infiltrates. the functional analysis of the clones demonstrated significantly higher proportions of clones w ... | 1987 | 3100453 |
| calcium participation in thyroid function in fowl (gallus domesticus). | the effects of the calcium antagonists ethyleneglycol-bis-(beta-aminoethylether)-n,n,n',n'-tetraace tic acid (egta), cobalt chloride (cocl2), and magnesium chloride (mgcl2) on the concentrations of plasma thyroxine (t4) and triiodothyronine (t3) and on the basal and stimulated release of t4 from incubated thyroid glands have been determined in the domestic fowl. plasma t4 levels were consistently reduced 2 hr after the administration of each calcium antagonist, although only egta and cocl2 lower ... | 1987 | 3100388 |
| [serum free thyroid hormones and response of tsh to trh in nonthyroidal illnesses]. | the change in the levels of free thyroid hormones and the pathophysiology of the hypothalamo-pituitary-thyroid axis of patients with nonthyroidal illness (nti) have not been clearly elucidated so far. therefore, it was thought of interest to investigate this problem by determining free thyroid hormones and tsh in serum and the response of tsh to trh in these patients. the subjects employed in this study were 71 cases with hemodialysis, 40 cases with diabetes mellitus, 24 cases with liver cirrhos ... | 1986 | 3100346 |
| effect of hypophysectomy on hypothalamic growth hormone-releasing factor content and release in the rat. | the possible regulation of hypothalamic gh-releasing factor (grf) by gh was studied in untreated and gh-treated hypophysectomized rats by measurement of rat hypothalamic grf content and release in vitro with a specific grf ria. two weeks after hypophysectomy, animals not receiving hormone replacement showed a marked reduction in hypothalamic grf content (to 28% of sham-operated control values; p less than 0.001). replacement therapy with t4, cortisone, and testosterone for 9 days did not correct ... | 1987 | 3100283 |
| iodide administration enhances thyrotrophin responsiveness to thyrotrophin-releasing hormone during fasting: evidence for normal pituitary feedback regulation. | short-term fasting in humans is associated with diminished delta tsh to trh. the purposes of the present study were to reassess basal tsh levels and trh responsiveness during fasting utilizing a sensitive radioimmunoassay (ria: sensitivity 0.3 microu/ml; normal range 0.66-2.98 microu/ml) and to determine if normal feedback regulation is maintained during the fasting state. eight control subjects (c) and six iodide-treated (i) subjects (262 mg/d) were studied in the fed state and on day 10 of fas ... | 1987 | 3100112 |
| effect of fenoprofen on thyroid function tests. | we observed that a few patients taking the anti-inflammatory drug fenoprofen showed increases in total and free t3 serum levels without convincing evidence of an associated thyrotoxicosis. to confirm these findings, two volunteers were given fenoprofen for two weeks. within this time total t3 levels almost doubled and free t3 levels increased threefold. administration of fenoprofen did not have any measurable effect on t4 or tsh estimations. cross-reactivities of fenoprofen and 4'-hydroxyfenopro ... | 1986 | 3100106 |
| on the albumin-dependence of measurements of free thyroxin. ii. patients with non-thyroidal illness. | we studied the relation between thyroxin-binding proteins and free thyroxin (ft4) measurements by five radioimmunoassays (ria) and an ft4 index (ft4i) in patients with non-thyroidal illness (nti). the one-step ft4 rias and the ft4i frequently failed to identify the true ft4 status (as determined by equilibrium dialysis) of nti patients. in these patients, falsely low ft4 results with one-step rias and ft4i were associated with decreasing total t3 and t4 concentrations, which, furthermore, parall ... | 1987 | 3100099 |
| extraction of human organ-specific cancer neoantigens from cancer cells and plasma membranes with 1-butanol. | immunoprotective tumor antigens of experimental tumors are selectively extracted by 1-butanol. human organ-specific cancer neoantigens (osns) are tumor substances in cancer extracts to which patients with cancer of the same organ respond in the in vitro assay of leukocyte adherence inhibition. here we determined whether osns as measured by leukocyte adherence inhibition assay are also selectively solubilized by 2.5% (v/v) 1-butanol. butanol extracts of live tissue-cultured human cancer cells as ... | 1987 | 3100029 |
| [thyroid reactions in wistar rats during the circadian rhythm after ganglionectomy at normal temperature and under cold exposure with regard to the influence of the epiphysis cerebri]. | serum thyroxin (t4), serum tsh, and pituitary tsh were measured by radioimmunoassay (ria) and serum cholesterol by liebermann-burchard reaction in rats 4 times a day (light-dark cycle: 14 l: 10 d) after gangliectomy (bilateral extirpation of the ganglia cervicalia superiora) at cold and normal temperature conditions. 80 male wistar rats were divided into 4 groups: sham-operated group, 24 degrees c (297 k); sham-operated group, 10 degrees c (283 k); gangliectomy, 24 degrees c (297 k), and ganglie ... | 1986 | 3099536 |
| comparison of the structure of human intervertebral discs in the cervical, thoracic and lumbar regions of the spine. | posterior and anterior heights, cross-sectional area and shape were measured for all the intervertebral discs in four spines from elderly human cadavers. disc height was a minimum at the t4-5 level; thoracic discs were less wedge-shaped than those in the cervical and lumbar regions. cross-sectional area increased from the cranial to caudal extremity; at the l5-s1 level the nucleus pulposus occupied a high proportion of this area. cervical discs tended to have an elliptical cross-sectional shape, ... | 1986 | 3099408 |
| lymphocyte populations and tac-antigen in diffuse b-cell lymphomas. | immune cell populations in 8 diffuse histology b-cell lymphomas were analysed in frozen tissue sections by indirect immunofluorescence to gain insight into their possible modulating influence in these tumors. use of monoclonal antibodies to identify cellular and extracellular antigens combined with nuclear counterstaining allowed precise quantitation, localization and comparison of t- and b-lymphocyte populations. t lymphocytes clustered in non-random fashion. areas of high t-lymphocyte density ... | 1986 | 3099093 |
| thyroid hormone effects on lactase expression by rat enterocytes. | thyroxine (t4) and triiodothyronine (t3) injected into adult rats causes first an increase and then a decrease in lactase activity measured subsequently in intestinal homogenates of rat jejunum. these changes are not associated with any alteration in intestinal structure or enterocyte migration rate. quantitative cytochemistry shows t4 stimulation and inhibition of lactase activity to take place in upper villus and crypt cells respectively (o- and c-enterocytes). t3 injected into thyroidectomize ... | 1986 | 3098965 |
| a detailed study of gerj mutants of bacillus subtilis. | a total of nine gerj mutants have now been isolated in bacillus subtilis. all are defective in their spore germination properties, being blocked at an intermediate (phase grey) stage. the dormant spores are sensitive to heating at 90 degrees c and two of the mutants (generated by transposon insertion) produce spores sensitive at 80 degrees c. the spores of these two more extreme mutants had a visibly defective cortex when studied by electron microscopy, as did some of the other mutants. during s ... | 1986 | 3098908 |
| reproductive hormone secretion and spermatogenic function in thyroidectomized rams receiving graded doses of exogenous thyroxine. | this study aimed to obtain a better understanding of the relationship between circulating thyroxine (t4) concentrations and reproductive endocrine function in the ram. mature merino rams were thyroidectomized and supplemented with 0, 30, 100 and 300% of normal t4 for 10 weeks. thyroidectomy had no apparent effect on spermatogenic function but interfered with sperm maturation, the latter being returned to normal by 30% t4 replacement. circulating testosterone levels were reduced by thyroidectomy ... | 1986 | 3098886 |
| dissection of defective antigen presentation by interferon-gamma-treated fibroblasts. | the capacity of interferon-gamma (ifn-gamma)-treated hla-dr expressing human dermal fibroblasts (fb) to function as antigen-presenting cells (apc) was examined. fb were cultured with 250 u/ml ifn-gamma for 4 days to induce hla-dr expression. peripheral blood monocytes (m phi), fb, or ifn-gamma-treated fb from the same donor were then cultured overnight with or without the recall antigen streptokinase streptodornase (sksd), and their capacity to stimulate autologous t4 cell dna synthesis was exam ... | 1987 | 3098840 |
| increased serum thyroglobulin concentrations and impaired thyrotropin response to thyrotropin-releasing hormone in euthyroid subjects with endemic goiter in sicily: their relation to goiter size and nodularity. | serum thyroglobulin (tg), t4, t3, ft4, ft3, tsh concentrations and tsh response to iv trh (delta tsh) were measured in 56 consecutive patients with (multi) nodular goiter from a severely iodine-deficient endemic goiter area in northeastern sicily and in 11 non goitrous euthyroid individuals living in the same area. serum tg concentrations were sharply increased in goitrous subjects (453 +/- 476 ng/ml) and related to thyroid size and the presence of nodules (chi 2 = 43.5, p less than 0.0005). ser ... | 1986 | 3098822 |
| hyperthyroxinemia due to the coexistence of two raised affinity thyroxine-binding proteins (albumin and prealbumin) in one family. | the t4-binding proteins of a euthyroid subject with persistent hyperthyroxinemia (t4, greater than 20 micrograms/dl) were present in normal concentrations. abnormal transport of both t4 and rt3 was demonstrated by reverse flow paper electrophoresis; excess t4 was bound to albumin and prealbumin, while increased binding of rt3 was confined to prealbumin. the three t4-binding proteins in the serum of the subject were isolated by affinity chromatography and characterized. equilibrium dialysis exper ... | 1987 | 3098776 |
| modification of the contractile activity of isolated atria by t4 lymphocytes from patients with chagas' disease: effect of soluble factors. | the results of this study show that peripheral blood mononuclear leukocytes of patients with chagas' disease (ch-pbmc) respond to challenge with homologous as well as with heterologous heart antigens releasing active soluble factors capable of increasing the contractile tension and frequency of beating rat atria. the reaction was related to t. cruzi infection rather than to the presence of cardiomyopathy. indirect evidence suggests that supernatants of ch-pbmc activated with heart tissue homogen ... | 1986 | 3098693 |
| surface markers of human lymphokine-activated killer cells and their precursors. analysis at the population and clonal level. | lymphokine-activated killer (lak) activity was first analyzed on pbl populations fractionated on the basis of the expression of t11 or t3 antigen. lak cell precursors were found to be present in both t11+ and t11- populations, but only in the t3- cell fraction. the generation of lak activity in highly purified t3- populations of pbl was not accompanied by expression of t3 antigen during a 5-day culture period. lak activity was next analyzed at the level of limiting dilution clonal microcultures. ... | 1987 | 3098689 |