Publications
| Title | Abstract | Year Filter | PMID(sorted descending) Filter |
|---|
| familial dysalbuminaemic hyperthyroxinaemia and other causes of euthyroid hyperthyroxinaemia. | clinical and biochemical studies on a family in which 3 members have familial dysalbuminaemic hyperthyroxinaemia (fdh) are presented. they were clinically euthyroid with elevated serum thyroxine (t4) and free t4 indices but normal free t4 by equilibrium dialysis and normal serum triiodothyronine (total and free). all thyroid function tests on the remaining family members were normal. the inheritance is consistent with autosomal dominance. also presented are data on 4 unrelated patients with fdh ... | 1987 | 3123677 |
| deletion analysis of the achaete-scute locus of drosophila melanogaster. | the achaete-scute gene complex (as-c) is involved in the development of the central and peripheral (sensory chaetae, sensilla) nervous system. to assess the contribution of the different parts of the complex in the generation of the adult chaetae pattern, we have determined the phenotypes and molecular positions of the breakpoints of 74 terminal deficiencies of the x chromosome. according to these and previous data, the as-c is organized, distally to proximally, as follows: the achaete region, w ... | 1987 | 3123318 |
| seasonal changes of the 5'-monodeiodination activity in kidney and skin homogenates of male rana ridibunda: relation to plasma thyroxine (t4) and testosterone. | plasma concentrations of thyroxine (t4) and testosterone were studied together with the in vitro 5'-monodeiodination activity in liver, kidney, and skin homogenates in male rana ridibunda during 12 consecutive months. plasma t4 levels increase in february, drop in april, and increase again in may. in july a sharp decrease is seen and the values remain low during the rest of the year. testosterone plasma levels also exhibit month to month variations. a maximum is found in february and march, and ... | 1987 | 3123309 |
| [study on the screening of thyroidal dysfunction in adult]. | for the purpose of screening of thyroidal dysfunction in adult, we have collected blood of 15,905 (male 11,559, female 4,346) adult normal workers and school students on filter papers at the time of the annual health examination. both tsh and total t4 were measured by radioimmunoassay. either tsh or total t4 or both showed abnormal values in 148 cases. for these subjects, serum tsh, total t4 and t3, free t4, tbg, antimicrosomal and antithyroglobulin antibody were estimated. from these results, d ... | 1987 | 3123285 |
| pituitary thyrotroph function and thyroid hormones in longstanding type-ii diabetes mellitus before and after insulin treatment. | we investigated the trh induced tsh secretion and thyroid hormone concentrations in 14 type-ii diabetics with secondary failure to oral hypoglycemic agents (mean age: 70.8 years, range: 55-77, mean duration of disease: 11 years +/- 7.9 sd, mean hbalc: 10.1 +/- 1.6 sd) with normal body weight before and after insulin therapy. results were compared with those of healthy control persons. before insulin treatment t3 and ft3 concentrations were significantly lower in diabetics (p less than 0.05) comp ... | 1987 | 3123258 |
| short pulses of low dose thyrotropin-releasing hormone do not affect thyroid hormone secretion from perfused dog thyroid lobes. | small amounts of trh are present in the thyroid, and trh has been shown in several studies to have a moderate direct inhibitory effect on tsh-stimulated thyroid hormone secretion. in a recent publication, however, data were presented to demonstrate that very low doses of trh given in short pulses induce immediate increases in t4 secretion from the thyroid. this type of secretion had never been observed previously. we have tried to reproduce these results employing perfused dog thyroid lobes in w ... | 1988 | 3123200 |
| high level of interferon gamma in tuberculous pleural effusion. | it has been observed that t-lymphocytes of patients with tuberculosis produce interferon gamma (ifn gamma) in vitro. based on this idea, we studied ifn gamma in pleural fluid and serum. we studied 80 patients with pleural effusion; 30 patients with tuberculous pleurisy had high ifn gamma concentrations in pleural fluid. patients with malignant pleural effusions, nonspecific pleural effusion, parapneumonic effusions and pleural transudates had low levels. the ifn gamma levels were higher in those ... | 1988 | 3123150 |
| ultrasensitive assay of thyroid stimulating hormone in patients with acute non-thyroidal illness. | serum tsh in critically ill euthyroid patients is generally within the normal range when measured with conventional radioimmunoassays. sensitive immunoradiometric assays allow detection of low levels of serum tsh. we assessed this method in a prospective study of 34 euthyroid patients admitted to our critical care unit. serum tsh ranged from 0.12 to 3.60 mu/l and was significantly lower for the whole group than in the controls (p less than 0.001), as also were serum total t4 and t3 values (p les ... | 1987 | 3123103 |
| chemically blocked analog assays for free thyronines. i. the effect of chemical blockers on t4 analog and t4 binding by albumin and by thyroxin-binding globulin. | analog assays for free thyroxin (ft4) produce inaccurate results because the t4 analog is sequestered by albumin. diagnostic products corp. (dpc) introduced the concept of chemically blocking analog-albumin binding in 1982. while dpc succeeded in eliminating albumin dependence, their 1985 version of chemically blocked ft4 assay appeared to be "thyroxin-binding globulin" (tbg) dependent, producing inappropriately low ft4 results with low tbg concentrations and high results with high tbg concentra ... | 1988 | 3123097 |
| chemically blocked analog assays for free thyronines. ii. use of equilibrium dialysis to optimize the displacement by chemical blockers of t4 analog and t3 analog from albumin while avoiding displacement of t4 and t3 from thyroxin-binding globulin. | chemical blockers used to displace thyronine analog from albumin in analog kits for assay of free thyroxin (ft4) or free triiodothyronine (ft3) may also displace thyroxin (t4) or triiodothyronine (t3) from thyroxin-binding globulin (tbg), resulting in an apparent tbg dependence of results of free hormone estimates. we used equilibrium dialysis and antibody binding to assess the displacement of thyronine analogs and thyronines from albumin and tbg by use of chemical blockers. we chose a combinati ... | 1988 | 3123095 |
| variability of response to thyroid-releasing hormone in normal elderly. | the present study was undertaken to define the hormonal response to thyroid-releasing hormone (trh) further in a large, healthy, ambulatory elderly group. seventy-seven subjects over 60 years old, 30 males (ma) and 47 females (fa), and control subjects, 22 males (mc) and 42 females (fc) were studied. no difference in thyroxine (t4), free thyroxine index (ft4i), baseline prolactin, and thyrotropin (tsh) concentrations were found between the four groups. tri-iodothyronine resin uptake was only dif ... | 1987 | 3122540 |
| influence of hormonal imprinting on hormone level. permanent receptor damaging effect of pituitary hormones administered to newly-hatched cockerels. | the overlapping effect of tsh and fsh on the gonad and on the thyroid gland can be demonstrated in cockerels even at the age of five weeks. these hormones influence the secretion of testosterone in a similar way and to a similar extent, while on the thyroxine level the influence of the specific hormone is more pronounced. neonatal fsh and tsh treatment considerably decreased the basal testosterone level measured at the age of five weeks. neonatal fsh treatment increased the basal t4 level while ... | 1987 | 3122523 |
| immunological profile after splenectomy in children with beta-thalassaemia major. | the in vitro immune functions of peripheral blood lymphocytes have been studied in 12 children with beta-thalassaemia major and hypersplenism. the study was performed prior to splenectomy and on the 2nd, 6th, 15th and 30th day after splenectomy. it was found that before splenectomy, patients had low numbers of blood leucocytes, normal rosette and t3 lymphocyte counts, low t4 and normal t8 lymphocyte counts with a t4/t8 ratio below 2, impaired t lymphocyte mitogenic responses induced by pha, incr ... | 1987 | 3122490 |
| in vivo activated lymphoid cells (ivalc) affect the cloning efficiency of human t lymphocytes reactive to a soluble antigen, purified protein derivative. | peripheral blood mononuclear cells (pbmc) of normal individuals were found to contain a proportion (4-9%) of in vivo activated lymphoid cells (ivalc). these ivalc were characterized by their expression of interleukin 2 (il-2) receptors, and by the ability to proliferate in the presence of exogenous il-2. there was a good correlation between the proportion of ivalc in different cell populations and the level of cell proliferation to il-2. it was found that ivalc isolated from autologous pbmc of b ... | 1987 | 3122312 |
| primary hypothyroidism in an adult patient with protein-calorie malnutrition: a study of its mechanism and the effect of amino acid deficiency. | a man with diabetes mellitus, chronic hepatitis, chronic pancreatitis, and blind loop syndrome but without any previous thyroid disease developed three episodes of transient primary hypothyroidism associated with protein-calorie malnutrition (pcm). clinical examinations suggested that this primary hypothyroidism was not caused by chronic thyroiditis, iodine deficiency, or iodine excess. since the three times association of primary hypothyroidism with pcm suggested the possibility that the primar ... | 1988 | 3121981 |
| interrelationship between estrogen and thyroxine on the release of luteinizing hormone and gonadotropin-releasing hormone in vitro. | the present experiments were designed to study the interaction between estradiol benzoate (eb) and thyroxine (t4) given in vivo on the responsiveness of pituitary luteinizing hormone (lh) to gonadotropin-releasing hormone (gnrh) and the release of gnrh in vitro. ovariectomized-thyroidectomized (ovx-tx) rats were injected s.c. with saline or t4 (2 micrograms/100 g b.wt), and oil or eb (0.1 microgram) once daily for 40 days following a 2 x 2 factorial design. all animals were then decapitated and ... | 1987 | 3121935 |
| pituitary-thyroid function in chronic renal failure assessed by a highly sensitive thyrotropin assay. | pituitary-thyroid function was assessed in 40 patients with chronic renal failure undergoing regular maintenance hemodialysis and in 35 normal subjects. serum thyroid hormone levels were significantly lower in the dialysis patients than in the normal subjects (p less than 0.001) and were in the hypothyroid range in a high proportion of dialysis patients (total t3, 25%; free t3, 45%; total t4, 55%; free t4, 45%; and free t4 index, 38%). the reduced free thyroid hormone levels could not be explain ... | 1988 | 3121662 |
| studies of thyroid function and immune parameters in patients with hyperthyroid graves' disease in remission. | the natural course of hyperthyroidism due to graves' disease after discontinuation of antithyroid drug therapy was studied in 184 patients who had been treated with methimazole and whose thyroid function was suppressible with t3 when methimazole was discontinued. the patients were followed after discontinuation of therapy for up to 60 months. serum t4, free t4 (ft4) and t3 levels, tsh receptor antibody (trab) and anti-dna antibody titers, and the percentage of hla-dr positive lymphocytes in peri ... | 1988 | 3121661 |
| thyroid function in "yusho" patients exposed to polychlorinated biphenyls (pcb). | thyroid function was investigated in 123 yusho patients who were exposed to toxic levels of polychlorinated biphenyls (pcbs) 16 years ago. in yusho patients, compared with the patients without evidence of yusho or normal controls, the serum triiodothyronine (t3) and thyroxine (t4) levels were significantly higher, while thyroid stimulating hormone (tsh) levels measured by sensitive assay were normal. there was no difference in serum levels of albumin, alkaline phosphatase, total cholesterol, and ... | 1987 | 3121298 |
| distribution of p24 htlv3 major core protein in lymph nodes of las patients. | lymph nodes of patients with lymphadenopathy syndrome (las) are characterized by two main histological patterns: hyperplastic reactive (h) and regressive (r). in both conditions, the paracortex (pc) is markedly activated with presence of selectively ia-1+ high endothelial venules. using a monoclonal antibody for p24, the major core protein of htlv3, we have immunohistochemically determined the distribution of p24+ cells in lymph nodes from 23 las patients' htlv3-ab serologically positive. p24+ c ... | 1987 | 3121180 |
| abnormal sweat electrolytes in symptomatic human immunodeficiency virus infection in a child. | a 3 1/2 year old girl presented with failure to thrive and a five month history of diarrhoea and recurrent cough. the results of sweat sodium tests suggested a diagnosis of cystic fibrosis; but atypical organisms were found (haemophilus influenzae, candida albicans, but no staphylococcus aureus), she failed to respond to treatment, and her sweat sodium concentrations fell in response to fludrocortisone. she also had hyperglobulinaemia, neutropenia, and reduced numbers of t4 lymphocytes, which pr ... | 1987 | 3121056 |
| post-operative analgesia by high thoracic epidural versus intramuscular nicomorphine after thoracotomy. part iii. the effects of per- and post-operative analgesia on morbidity. | one hundred and twenty-nine patients were subjected to three different types of thoracic operations. the patients were randomly allocated to balanced intravenous anaesthesia including i.v. nicomorphine during surgery and epidural nicomorphine post-operatively (epidural group, n = 58) or to balanced intravenous anaesthesia without i.v. opiates but with high thoracic epidural regional block during the operation and with post-operative intramuscular nicomorphine (intramuscular group, n = 71). post- ... | 1987 | 3120484 |
| structure and function of a new hemoglobin variant, hb meilahti (alpha 2 beta 2 36(c2)pro----thr), characterized by mass spectrometry. | an abnormal hemoglobin was found by isoelectric focusing in the blood of a finnish woman with erythrocytosis. oxygen equilibrium curves of the patient's hemolysate indicated the presence of a variant with a very high oxygen affinity. structural analysis was carried out by mass spectrometry. in the spectrum of the tryptic digest, an abnormal peptide was found at m/z1278 which corresponded to the mass number of the protonated molecular ion of beta t4 with 36pro----thr substitution. the structure w ... | 1987 | 3120455 |
| handling of iodothyronines by the liver and kidney in patients with chronic liver disease. | possible arterio-venous gradients of t4, t3, rt3 and 3,3'-diiodothyronine (3,3'-t2) across the liver and the kidneys were measured in 9 patients with varying degrees of liver failure undergoing diagnostic catheterization. plasma iodothyronine levels were measured in peripheral, hepatic and renal veins before and at 10-min intervals until 60 min after iv injection of 400 micrograms of trh. in 2 patients estimated hepatic plasma flow and effective renal plasma flow were determined as well. in thes ... | 1987 | 3120447 |
| [the effect of beta-carotene on thyroxine and cholesterol levels in pregnant heifers before and after parturition]. | thyroxine (t4) and cholesterol concentrations and their dynamic changes and differences were studied in 20 pregnant heifers 10 days before calving until 56 days after calving. ten control heifers were fed the feed ration for pregnant heifers according to czechoslovak standard csn 46 7070. the feed ration given to another ten (experimental) heifers was fortified with 300 mg of synthetic beta-carotene per head/day within the period of five months before insemination, during pregnancy and till the ... | 1987 | 3120391 |
| zinc (ii) and the single-stranded dna binding protein of bacteriophage t4. | the dna binding domain of the gene 32 protein of the bacteriophage t4 contains a single "zinc-finger" sequence. the gene 32 protein is an extensively studied member of a class of proteins that bind relatively nonspecifically to single-stranded dna. we have sequenced and characterized mutations in gene 32 whose defective proteins are activated by increasing the zn(ii) concentration in the growth medium. our results identify a role for the gene 32 protein in activation of t4 late transcription. se ... | 1987 | 3120192 |
| bacteriophage t4 rega protein binds to mrnas and prevents translation initiation. | the bacteriophage t4 rega protein is a translational repressor of a subset of phage mrnas. we show here that purified rega protein binds specifically to target mrnas near the initiating aug and occludes binding of ribosomes. translational repression by rega protein diminishes expression of many genes whose mrna sequences around the initiating aug codons are different. a comparison of nucleotide sequences from several rega-repressed mrnas suggests that the initiating aug is an important, but not ... | 1987 | 3120177 |
| [a case report of an advanced ovarian cancer (stage t4) treated with a total amount of 1815 mg of cddp]. | a case is reported of a 34-year-old female who complained of an adult head-sized tumor in the pelvis and was treated with a high dose of cddp. on the first look operation, it was found impossible to perform reduction surgery because of severe adhesion and peritonitis carcinomatosa. to introduce a high concentration of an anti-cancer agent into the tumor tissue, we administered cddp intravenously, intraperitoneally and intra-arterially to the total amount of 1815 mg. after this high dose combinat ... | 1987 | 3119892 |
| effects of plasmapheresis on peripheral blood mononuclear cell populations from patients with macroglobulinemia. | effects of plasmapheresis on peripheral blood t-cell, b-cell, monocyte, and natural-killer-cell populations were studied in ten macroglobulinemia patients with hyperviscosity syndrome. following plasmapheresis, there was a transient decrease in the number of t4+ helper cells and a longer-lasting decrease in the number of leu-7+ natural killer cells and mo2+ monocytes. in addition, there was a greater than 50% decrease in the in vitro ingestion capacity of monocytes. although no significant chang ... | 1987 | 3119575 |
| endocrine function changes in young males during long-term antiepileptic therapy with phenobarbitone and carbamazepine. | the effects of long-term antiepileptic combined therapy with phenobarbitone (pb) and carbamazepine (cbz) on the major endocrine functions were evaluated in a selected group of 15 young males with partial epilepsy. the plasma basal levels of triiodothyronine (t3), thyroxine (t4), free thyroxine (ft4), thyrotropin (tsh), cortisol (co), dehydroepiandrosterone-sulfate (dhea-s), adrenocorticotropin (acth), growth hormone (gh), prolactin (prl) and testosterone (t) were determined. tsh and prl were als ... | 1987 | 3119517 |
| immunoelectron microscopic observations on the inflammatory infiltrates and hla antigens in hepatitis b and non-a, non-b. | the present knowledge of the inflammatory reaction occurring in situ during hepatitis b favors a t cell-dependent mhc-restricted immune response. however, the reports in the literature are primarily based on the application of monoclonal antibodies directed at different lymphocyte subsets which discern only lymphocytic phenotypes and do not reflect the actual situation adequately. therefore, we investigated the liver biopsies of patients with hepatitis b (28 patients) and non-a, non-b (21 patien ... | 1987 | 3119453 |
| monitoring treatment of congenital hypothyroidism by highly sensitive immunoradiometric assay for thyroid stimulating hormone. | to assess the clinical value of a sensitive immunoradiometric assay for tsh (irma-tsh), serum irma-tsh levels were compared with those of a radioimmunoassay (ria-tsh) in twenty-eight patients with congenital hypothyroidism. among 144 samples taken from them, 44 samples showed undetectable ria-tsh, while only 10 samples were undetectable by irma-tsh. in two patients prospectively followed, ria-tsh levels were undetectable when serum t3 and t4 were normal. irma-tsh levels, however, were detectable ... | 1987 | 3119318 |
| galactorrhea in subclinical hypothyroidism. | galactorrhea was found in 5 patients with subclinical hypothyroidism. the galactorrhea consisted of the discharge of a few drops of milk only under pressure. serum t4 was in the lower level of the normal range, but serum t3 was normal (t4: 6.3 +/- 1.2 micrograms/dl, t3: 113 +/- 7 ng/dl). basal serum tsh and prl were slightly increased only in 2 and 1 cases, respectively. the prl responses to trh stimulation were exaggerated in all cases, although the basal levels were normal. an enlarged pituita ... | 1987 | 3119317 |
| repetitive or continuous thyrotropin (tsh)-releasing hormone administration induces a biphasic rise in plasma tsh in euthyroid but not in hypothyroid rats. | in euthyroid rats, repetitive bolus injections of 0.1, 1, or 5 micrograms/100 g bw trh every 15 min for 2 h produced a biphasic rise in the plasma tsh concentration. after an initial peak at 15 min, plasma tsh fell at 60 min to a nadir 50-80% of the 15-min peak, then rose again by 90 min to a plateau with approximately the same amplitude as the initial peak. plasma tsh remained at this level until trh injections were stopped at 2 h, then fell to the pre-trh baseline by 3 h. a similar biphasic ri ... | 1987 | 3119311 |
| human blood basophils display a unique phenotype including activation linked membrane structures. | to evaluate the membrane marker profile of human basophils a panel of well-established monoclonal antibodies (moabs, n = 60) was used for a combined toluidine/immunofluorescence staining procedure. myeloid-associated moabs (particularly moabs against the lfa-1 family (cd11, cdw18), moabs directed against lactosylceramide (cdw17), anti-glycoprotein (gp) 150 moabs mcs 2 and my 7 (cdw13), anti-gp 67 moab my 9, anti fc gamma-receptor (mol wt 40 kd) moab cikm5, anti-cr 1 moab e 11, and the antiglycol ... | 1987 | 3118989 |
| thyroid status in senile dementia of the alzheimer type (sdat). | thyroid function was investigated in a group of 21 patients with severe senile dementia of the alzheimer type (sdat) and in a group of 17 age and sex matched normal controls. free thyroid hormone levels (triiodothyronine (t3) and thyroxine (t4) were measured, as were also the thyrotrophin (tsh), prolactin (prl) and growth hormone (gh) responses to thyrotrophin releasing hormone (trh)). when compared to controls, patients demonstrated a significantly lower free t3 value (but not free t4), a blunt ... | 1987 | 3118642 |
| effect of interferon gamma on expression of hla-class ii molecules on blood-derived dendritic cells. | t4 cells recognize antigen together with hla class ii molecules in the membrane of antigen-presenting cells (apc). the magnitude of the induced t cell response is in part dependent upon the quantitative expression of hla-class ii molecules in the cell membrane of the apc. we report here that recombinant interferon gamma (ifn-gamma) may enhance the expression of hla class ii molecules on the surface membrane of blood-derived dendritic cells by 30-90%. | 1987 | 3118639 |
| thyrotropin response to thyrotropin-releasing hormone in rats with hypothalamic knife cuts. | regulation of the pituitary-thyroid axis in rats with hypothalamic knife cuts has been studied. complete hypothalamic deafferentation, either limited to the median eminence and the arcuate nucleus, or including parts of the dorsomedial nucleus and the whole ventromedial nucleus caused an increase in thyrotropin (tsh)-releasing hormone (trh)-induced tsh secretion. using an immunocytochemical procedure, a few trh-positive fibers were observed within the median eminence of the larger island, while ... | 1987 | 3118229 |
| hiv f/3' orf encodes a phosphorylated gtp-binding protein resembling an oncogene product. | apart from the retroviral gag, pol and env the hiv genome contains the f (3' orf) gene which encodes a polypeptide of 206 amino acids which is myristylated at the n-terminal and whose function is unknown. we have expressed the f gene in escherichia coli and from a recombinant vaccinia virus, vvtgfhiv. the f-protein produced in vvtgfhiv-infected mammalian cells is myristilated, and is phosphorylated by protein kinase c at a residue close to the n-terminus like pp60-src (ref. 5). purified bacteria ... | 1987 | 3118220 |
| contributions of hydrogen bonds of thr 157 to the thermodynamic stability of phage t4 lysozyme. | measurements of changes in structure and stability caused by 13 different substitutions for threonine 157 in phage t4 lysozyme show that the most stable lysozyme variants contain hydrogen bonds analogous to those in the wild-type enzyme and that structural adjustments allow the protein to be surprisingly tolerant of amino-acid substitutions. | 1987 | 3118211 |
| thyrotropin hyperresponsiveness to trh despite hyperthyroxinemia in amiodarone-treated subjects. | pituitary responsiveness to trh was assessed prospectively over 24 weeks, in 15 patients receiving 300 mg amiodarone a day. all developed significant hyperthyroxinemia (both total and free), and marked elevations in reverse t3 compared to pretreatment levels. although basal tsh levels were unchanged in all of them, tsh increased by greater than 50% when compared to pretreatment responses, in eight patients, while they remained unchanged (+/- 15%) in the remaining seven. all eight with exaggerate ... | 1987 | 3118137 |
| t cell-derived blast crisis in chronic myelocytic leukemia. | we describe herein the occurrence of a t cell-derived blast crisis of chronic myelocytic leukemia which presented as a typical t cell leukemia on clinical (thymic mass and high white blood cells) and immunological grounds (t6+ t4+ t8+), with rearranged t cell receptor genes and germ line immunoglobulin genes. a philadelphia chromosome was detected in all blast cell mitoses. the significance of t cell involvement during the chronic and acute phases of chronic myelocytic leukemia is discussed. | 1987 | 3118106 |
| purification and characterization of rna polymerase from the cyanobacterium anabaena 7120. | a procedure for the purification of rna polymerase from vegetative cells of the filamentous cyanobacterium anabaena 7120 is described. polyethyleneimine precipitation followed by gel filtration and affinity chromatography steps results in greater than 99% purification with 46% yield. the enzyme has a novel core component of mr = 66,000, designated gamma, in addition to the typical prokaryotic beta'beta alpha 2 core enzyme. the sigma subunit has been identified by reconstitution of specific trans ... | 1987 | 3117788 |
| highly purified human t-lymphocytes do not respond to mitogens--including calcium ionophore and phorbol ester. | the proliferative, and other, in vitro responses of human lymphocytes are dependent upon interactions with accessory cells. studies of the nature of these required interactions are dependent upon the ability to isolate functionally pure populations of lymphocytes and accessory cells. we describe here a four-step separation procedure using plastic adherence, passage through columns of nylon wool and sephadex g-10, and treatment with l-leucine methyl ester which produced t-lymphocyte populations w ... | 1987 | 3117683 |
| [the effect of serum free fatty acid on serum free thyroid hormone fractions in low t3 syndrome]. | we studied the role of serum free fatty acid (ffa) in the elevation of serum dializable fraction of t4 (dft4) and evaluated the serum free t4 (ft4) level in low t3 syndrome. serum dft4 and dft3 were measured by equilibrium dialysis method with phosphate buffer, and serum ffa concentration was obtained by gas chromatography. in patients with nonthyroidal systemic illnesses who showed reduced serum total t3 (tt3) and normal total t4 (tt4) (low t3 group, tt3 48 +/- 14 ng/dl, n = 10), mean (+/- sd) ... | 1987 | 3117601 |
| time-course of alterations of high density lipoproteins (hdl) during thyroxine administration to hypothyroid women. | serum hdl cholesterol, apolipoproteins ai and aii and post heparin lipolytic activities (phla) have been measured in a group of fourteen hypothyroid women without ovarian oestrogen secretion before and during a 2-month thyroxine treatment. the more rapid and consistent observed event was a decrease in apo ai levels (164 +/- 5 vs. 149 +/- 5 mg dl-1, mean +/- sem, p less than 0.05) correlated (r = 0.79, p less than 0.05) to a slight increment of phla. a slight decrease in apo aii concentration was ... | 1987 | 3117568 |
| carcinoma of the subglottis. results of initial radical radiation. | during the 12-year period 1971 to 1982, 23 patients with primary squamous cell carcinoma of the subglottis were treated with initial radical radiation therapy. there were 19 men and four women, with a mean age of 64 years. five patients had t1 tumors, four had t2, three had t3, and 11 had t4. the actuarial overall and cause-specific survival rates were 26% and 61%, respectively. local control was achieved with initial radiation therapy in 16 patients (70%). subsequent local control was achieved ... | 1987 | 3117073 |
| effects of vitamin a and/or thyroidectomy on liver microsomal enzymes and their induction in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats. | vitamin a and thyroid hormone status have been shown previously to alter the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) in rats. in the present study, we have examined the effects of a vitamin a-excess and a vitamin a-deficient diet on thyroid hormone levels, on selected drug-metabolizing enzymes in liver microsomes, and on their inducibility by tcdd in male sprague-dawley rats. except for a slight increase in serum t3 levels, none of these end points was affected by feeding rats the ... | 1987 | 3116724 |
| thyroid-hypophyso-hypothalamic axis of the genetically hypoprolactinemic rats (ipl nude rats). | in order to evaluate thyrotropin function in the genetically hypoprolactinemic rat, (ipl nude), we measured by radioimmunoassay trh hypothalamic content, pituitary tsh content and serum tsh, t3, t4, both in ipl nude and control rats at various times over the 24-hour period. compared to normal rats, the hypothalamic trh content in the ipl nude rat showed similar variations during the day, whereas a slight increase was observed during the night characterized by a significant difference at 20.00 h. ... | 1987 | 3116445 |
| [immunologic surveillance of liver transplant patients using monoclonal antibodies against lymphocyte subpopulations]. | a precise immunological surveillance of liver graft recipients can allow the adaptation to each patient of an adequate immuno-suppressive treatment. in 11 liver-transplanted patients (7 primitive biliary cirrhoses, 2 post-hepatic cirrhoses, one bile duct atresia with one antitrypsin deficit) different lymphocyte subpopulations were tested before transplantation and at days 3, 5, 7, 15, 30, 60 and 120 after grafting using okt3, okt4, okt8 (orthoclone, france). in 6 patients presenting one or more ... | 1987 | 3116444 |
| thyroid hormone modulation of thyrotrophin-releasing hormone (trh) and trh-gly levels in the male rat reproductive system. | thyrotrophin-releasing hormone (trh) occurs in high concentrations in the rat ventral prostate and its concentrations is regulated in a positive dose-response manner by testosterone in castrated rats. alpha-amidation of the tetrapeptide precursor, trh-gly, is a rate-limiting step in trh biosynthesis. to investigate further the hormonal regulation of trh biosynthesis in prostatic tissue, sprague-dawley rats of approximately 250 g were injected s.c. with either physiological saline or 3 mg propylt ... | 1987 | 3116140 |
| reduced clearance rate of thyroxine-binding globulin (tbg) with increased sialylation: a mechanism for estrogen-induced elevation of serum tbg concentration. | hyperestrogenemic states, including pregnancy, cause an increase in serum t4-binding globulin (tbg) concentrations and an increase in the proportion of tbg molecules with greater anodal mobility on isoelectric focusing, indicating greater sialic acid content. the possible causal relationship between the degree of sialylation and accumulation of tbg in serum was explored by measuring the in vivo half-lives (t1/2) of tbgs with different isoelectric points. tbg in unfractionated serum and its major ... | 1987 | 3116030 |
| thyroxine transfer and distribution in critical nonthyroidal illnesses, chronic renal failure, and chronic ethanol abuse. | serum t4 kinetic studies were performed in euthyroid patients with acute critical illnesses, chronic renal failure, or ethanol abuse without overt hepatocellular damage and in healthy euthyroid subjects with normal or altered serum t4 binding to determine the relative effects of altered serum t4 binding and extravascular disturbances on t4 transfer and distribution in nonthyroidal illnesses. a three-pool model with rapidly and slowly equilibrating pools exchanging with serum was used to evaluate ... | 1987 | 3116027 |
| dna ligase from drosophila melanogaster embryos. substrate specificity and mechanism of action. | dna ligase has been purified to homogeneity from 6-12 h drosophila melanogaster embryos (rabin, b. a., hawley, r. s., and chase, j. w. (1986) j. biol. chem. 261, 10637-10645). this enzyme had an apparent km for atp of 1.6 microm. of a variety of nucleotides tested, only adenosine 5'-o-(3-thio)triphosphate could substitute for atp in the joining reaction. the enzyme was competitively inhibited by datp, with an apparent ki of 2.3 microm. the apparent km for dna using p(dt)20 annealed with poly(da) ... | 1987 | 3115985 |
| the role of thyroid hormone as a biological amplifier of the actions of follicle-stimulating hormone in the functional differentiation of cultured porcine granulosa cells. | to characterize thyroid hormone action on the ovary, the direct effects of t4 or t3 were investigated in vitro using a monolayer culture system of porcine granulosa cells. monolayer cultures were maintained for 6 days in 4% serum-supplemented medium in the absence or presence of porcine fsh (20 ng/ml), with or without graded doses of t4 or t3. combined treatment with fsh and t4 (10(-7) m) induced morphological alternation resembling epithelioid cells, while fsh alone or t4 alone failed to bring ... | 1987 | 3115761 |
| effect of thyroxine replacement therapy on plasma insulin-like growth factor 1 levels and growth hormone responses to growth hormone releasing factor in hypothyroid patients. | the aim of this study was to evaluate the effect of t4 replacement therapy on plasma insulin-like growth factor 1 (igf-1) levels in patients with primary hypothyroidism to see whether recovery of pituitary gh responsiveness to grf was associated with increased plasma igf-1 levels. igf-1 levels and gh responses to grf (1 microgram/kg) were measured in 21 patients with primary hypothyroidism before and after t4 replacement therapy. t4 increased plasma igf-1 levels (57.2 +/- 4.4 vs 75.9 +/- 8.8 ng/ ... | 1987 | 3115637 |
| establishment of an interleukin 2-dependent human t cell line from a patient with t cell chronic lymphocytic leukemia who is not infected with human t cell leukemia/lymphoma virus. | we established an interleukin 2 (il-2)-dependent human t cell line, kit 225, from a patient with t cell chronic lymphocytic leukemia (t-cll) with okt3+, -t4+, -t8- phenotype. southern blot analysis showed that kit 225 is not infected with human t cell leukemia/lymphoma virus (htlv) type i or ii, and is probably derived from the major clone in the fresh leukemic cells. kit 225 cells express a large amount of il 2 receptors constitutively and their growth is absolutely dependent on il 2. no other ... | 1987 | 3115332 |
| establishment of a common acute lymphoblastic leukemia cell line (lc4-1) and effects of phorbol myristate acetate (pma) on the surface antigen expression of the cell line. | a common acute lymphoblastic leukemia (all) cell line, designated lc4-1, was established from peripheral blood mononuclear cells of a patient with acute non-t-cell all. lc4-1 cells were characteristically positive for ia, b4, and common all antigens (calla), but negative for b2, tac, t3, t4, t8, t11, and m1 antigens and e-rosette formation. approximately 30% of lc4-1 cells expressed detectable amounts of b1 antigens. lc4-1 cells expressed neither epstein-barr-virus-associated nuclear antigen (eb ... | 1987 | 3115091 |
| [detection of thyroid hormone antibodies using a radial immunodiffusion method]. | t3 and t4 autoantibodies just as protein binding anomalies are the cause of discrepancies of thyroid hormone assays as against actual thyroid function. depending on the separation techniques used, autoantibodies lead to false low or high t3 or t4 values. a series of 105 preselected thyroid patients was investigated as to the presence of t3 and t4 autoantibodies. only in one of these patients t3 autoantibodies could be documented as cause for elevated ft3 values in otherwise euthyroid function (c ... | 1987 | 3115039 |
| the role of t4+ and ly-2+ cells in skin graft rejection in the mouse. | the role of the different t cell subsets (t4+ or ly-2+) cells in the rejection of murine skin grafts was examined using the in vivo injection of monoclonal antibodies. the rat antimouse monoclonal antibodies used were shown to be active in vivo and to successfully deplete t4+ or ly-2+ cells. h-2 mutant strains were used so that class i or class ii mhc antigens could be studied in isolation; non-h-2 antigenic differences were also examined. the results were clear: (a) for class i antigens, ly-2+ ... | 1987 | 3114924 |
| plasma somatotropin and somatomedin c concentrations following grf or trh injections in newborn calves. | plasma somatotropin (gh) and somatomedin c (igf1) concentrations were measured by radioimmunoassay in 3-dy old and 10-day old calves intravenously injected with growth hormone releasing factor (grf) 1-44, grf 1-29 or thyrotropin-releasing hormone (trh). in 3 day old animals the increase in plasma gh concentration was grf 1-44 dose-related (50, 100, 200 pmoles . kg(-1) of body wt). in four 10-day old calves injected with the lowest dose, the increase in plasma gh concentration was not different f ... | 1987 | 3114840 |
| effects of trh and grf administration on gh, tsh, t4 and t3 secretion in the lamb. | the effects of various amounts of thyrotropin-releasing hormone (trh) injected subcutaneously or intravenously (alone or in combination with growth hormone-releasing factor: grf 1-44) on growth hormone (gh), thyroid-stimulating hormone (tsh), thyroxine (t4) and triiodothyronine (t3) were studied in the plasma of 2-week, 2-month and 3-month old lambs. after subcutaneous trh administration, increases in plasma tsh, t4 and t3 levels were equivalent, whatever the amount of trh used (1,2,5 or 10 micr ... | 1987 | 3114838 |
| external beam irradiation for t1, t2-3 and t4 transitional cell carcinoma of the urinary bladder. | fifty-seven patients with t1 transitional cell carcinoma of the bladder, 57 patients with t2-3 and 10 patients with t4 were treated by radical irradiation +/- salvage cystectomy. thirty-five patients with t1 were treated by transurethral resection (tur) plus local chemotherapy +/- salvage cystectomy. eleven patients with t2-3 were treated with 5 x 4 gy in one week followed by cystectomy while four patients with t2-3 were treated with 40 gy in 4 weeks also followed by cystectomy. five patients wi ... | 1987 | 3114833 |
| squamous cell carcinoma of the pyriform sinus treated with radical radiation therapy. | this is an analysis of 54 patients with squamous cell carcinoma of the pyriform sinus treated with radical irradiation at the university of florida between october 1964 and march 1984. there is a 2-year minimum follow-up on all patients and 85% have at least 5 years of follow-up. patients were excluded from analysis of disease control at the primary site, neck, and/or above the clavicles if they died less than 2 years from treatment with the site(s) continuously disease-free. all patients were i ... | 1987 | 3114832 |
| [[analysis of synergistic effects during thermoradiation exposure of bacteriophage t4 and bacillus subtilis spores]. | experimental data are interpreted in terms of a half-empiric model of synergism obtained for bacteriophage t4 and bacillus subtilis spores exposed to ionizing radiation of different dose rates at elevated temperatures. the model permits to optimize the ratio of both factors for effective sterilization. | 1987 | 3114821 |
| hypothalamic-pituitary-thyroidal dysfunctions in anorexia nervosa. | there are clinical similarities between anorexia nervosa and hypothyroidism. circulating levels of t4 and particularly t3 have been reported to be low in this eating disorder. previous reports have, however, shown normal basal levels of serum tsh with normal or delayed responses to trh. to assess thyroid function and the hypothalamic-pituitary axis in 21 women with anorexia nervosa, serum levels of free and total thyroid hormones, binding proteins, and tsh employing an extremely sensitive assay ... | 1986 | 3114819 |
| comparison of the effects of pulsatile and continuous trh infusion on tsh release in men. | pulsatile secretion of hypothalamic releasing factors modulates the release of pituitary hormones. to compare the effects of pulsatile and continuous administration of trh on tsh secretion, we studied six healthy euthyroid 20- to 38-year-old men by obtaining blood samples every 20 minutes for 12 hours (8 am to 8 pm) during five days of study. trh was administered according to the following schedule: day 1 (no trh, control); day 2 and subsequent day 3 (20 micrograms iv bolus of trh every 96 minut ... | 1987 | 3114594 |
| inhibition of the response of thyrotrophin to thyrotrophin-releasing hormone by thyroxine in hypothyroid rats treated with iopanoic acid: evidence suggesting an intrinsic biological activity of thyroxine without prior conversion to 3,5,3'-tri-iodothyronine. | the effects of a physiological replacement dose of thyroxine (t4) on the response of plasma tsh to trh in hypothyroid rats were studied. animals were treated with iopanoic acid (iop; 5 mg/100 g body weight) or vehicle 24, 12 and 1.5 h before the experiment. thereafter, 800 ng t4/100 g body weight were administered i.v. and 20 min later 1 microgram trh/100 g body weight was injected i.v. in control rats the basal concentration of tsh was 1450 +/- 300 (s.e.m.) mu./1. the plasma concentration of ts ... | 1987 | 3114404 |
| multiple sclerosis: relevance of class i and class ii mhc-expressing cells to lesion development. | expression of class i (hla-abc) and class ii (hla-dr; ia) major histocompatibility (mhc) antigens on endothelial cells and astrocytes was investigated in multiple sclerosis (ms) lesions of variable disease activity and in normal central nervous system (cns) using immunocytochemical techniques. findings were correlated to lesion pathology and to the presence and distribution of t cells, t cell subsets, and interleukin-2 (il-2) receptor-bearing cells. hla-abc was present on virtually all endotheli ... | 1987 | 3114324 |
| long term follow-up of patients with cushing's disease treated by interstitial irradiation. | the first 86 patients with cushing's disease treated with interstitial irradiation (by needle implantation) as the sole therapy were reviewed. in the 82 patients who were reassessed 1 yr after treatment 63 (77%) achieved remission. this study comprises the outcome and complications in the 54 patients who had a remission and whom we were able to follow. the follow-up period ranged from 3-26 yr (mean, 10.5) from the time of remission. no instance of clinical or radiological relapse has occurred. o ... | 1987 | 3114299 |
| congenital thyroxine binding globulin deficiency: incidence and inheritance. | ninety-nine cases of thyroxine binding globulin (tbg) deficiency (90 males and 9 females) were identified among low-t4 infants after newborn hypothyroid screening. the data indicate that inherited tbg deficiency occurs in at least 1:5,000 newborns (1:2,800 males) and that mild and more pronounced forms are found in approximately equal proportions. genetic analysis indicates that x-linked inheritance is the usual mode with no suggestion of autosomal inheritance. | 1987 | 3114125 |
| melatonin: its antagonism of thyroxine's antisomatotrophic activity in male syrian hamsters. | the effects of daily evening melatonin injections on serum and pituitary levels of growth hormone (gh) and follicle stimulating hormone (fsh) were investigated in male syrian hamsters receiving thiourea in the drinking water. melatonin injections, by themselves, had no significant effect on serum or pituitary gh. thiourea induced hypothyroidism reduced pituitary gh content but increased serum gh several fold. daily thyroxin (t4) injections for 3 weeks partially restored pituitary gh content and ... | 1987 | 3114053 |
| increased gonadotropin levels in goldfish do not result in alterations in circulating thyroid hormone levels. | to determine whether increases in gonadotropin levels are capable of altering thyroid function in goldfish, plasma thyroid hormone levels were measured following induced changes in endogenous gonadotropin secretion and injection of carp gonadotropin. radio-frequency lesions placed in the nucleus preopticus periventricularis or monosodium-l-glutamate-induced lesions of the posterior nucleus lateralis tuberis (nlt) of the hypothalamus were capable of stimulating significant increases in plasma gon ... | 1987 | 3114043 |
| serum thyroid hormone levels in patients with fulminant hepatitis: usefulness of rt3 and the rt3/t3 ratio as prognostic indices. | to evaluate thyroid function in 19 patients with fulminant hepatitis (fh), we have measured total and free 3,5,3'-triiodothyronine (t3) and thyroxine (t4), 3,3',5'-triiodothyronine (reverse t3, rt3), thyroid-stimulating hormone (tsh) and thyroxin-binding globulin (tbg) in patients with fh, compared with those of 80 patients with other various liver diseases and of 10 healthy controls. patients with fh showed the lowest values of serum t3 and the highest levels of rt3 among all patients with live ... | 1987 | 3114036 |
| proliferation and immunoglobulin synthesis of peripheral blood mononuclear cells from patients with chronic liver disease stimulated by staphylococcus aureus cowan 1 and interleukin 2. | proliferation and igg synthesis of peripheral blood mononuclear cells (pbmc) in response to stimulation with recombinant interleukin 2 (il-2) and staphylococcus aureus cowan 1 (sac) were evaluated in 32 patients with chronic persistent hepatitis (cph), chronic active hepatitis (cah) and liver cirrhosis (lc). eleven patients had serum hbe antigen, 10 presented with hbe antibody and 11 had non-a, non-b hepatitis. igg synthesis of pbmc induced with the two stimuli was significantly decreased in pat ... | 1987 | 3114035 |
| fast neutrons in the treatment of locally advanced breast cancer. | the clinical investigation of fast neutrons at hammersmith hospital included 17 patients who between them had 20 t4 breast cancers. the majority of these tumours were ulcerated and all were painful. ten had recurred after multiple other therapies. complete local regression was achieved in all but one (95%) and no tumour recurred. symptoms were relieved in all cases. median survival was 26 months. three patients developed small areas of skin necrosis following trauma of previous radiation. all th ... | 1987 | 3114006 |
| effect of thyroid hormone dosage on thyroid function tests in t4-replaced hypothyroid patients. | 1987 | 3113844 | |
| use of whole blood methods in assessment of immune parameters in immunodeficiency states. | whole blood (wb) methods requiring less than 4 ml heparinized peripheral blood were used to define mononuclear cell phenotype, lymphocyte proliferation, and natural cell-mediated cytotoxicity (cyt) in samples from normal controls and patients with immunodeficiency states of acquired immunodeficiency syndrome (aids) and aids-related complexes (arc). results from two-color direct immunofluorescence staining of blood samples with monoclonal antibodies (mabs) conjugated to phycoerythrin (pe) or to f ... | 1987 | 3113759 |
| spontaneous human t-cell cytotoxicity against murine hybridomas expressing the okt3 monoclonal antibody: comparison with natural killer cell activity. | human peripheral blood lymphocytes (pbl) exhibited spontaneous cytotoxicity against okt3 monoclonal antibody (mab)-expressing murine hybridoma cells (okt3 hybridomas). in contrast, other murine hybridomas expressing okt4, okt8, anti-hla dr, and anti-hla a, b, and c mab were not lysed. pbl showed much lower levels of cytotoxicity (3 folds) against okt3 hybridomas as compared with nk activity against the k562 targets. lymph node (ln) cells exhibited the inverse relationship of cytotoxicity levels. ... | 1987 | 3113742 |
| lysis of fresh solid tumor targets in the presence of con a is mediated primarily by leu 7+ peripheral blood t lymphocytes: blocking by the anti-cd3 monoclonal antibody and comparison with recombinant interleukin 2-induced lysis by natural killer cells. | we investigated the lysis of fresh human solid tumor cells by peripheral blood t lymphocytes in the presence of lectins and anti-cd3 monoclonal antibodies (mab). addition of certain lectins (con a, pha, or wga) directly into the 4-hr 51cr-release assay caused significant lysis of (p less than 0.001) noncultured solid tumor targets by enriched populations of granular lymphocytes (gl). significant levels (p at least less than 0.001) of con a- or pha-dependent solid tumor lysis by gl-enriched lymph ... | 1987 | 3113741 |
| developing antler, a model for endocrine regulation of bone growth. concentration gradient of t3, t4, and alkaline phosphatase in the antler, jugular, and the saphenous veins. | thyroxine (t4), triiodothyronine (t3), and alkaline phosphatase (ap) were assayed monthly in white-tailed deer plasma obtained from the antler (a), jugular (j), and the saphenous (s) veins during the period of antler growth and the period of mineralization. the concentrations of t3, t4, and ap in the j and s were not significantly different in any month. during the most intense antler growth period (june and july) ap levels were significantly higher and t3 significantly lower in a as compared to ... | 1987 | 3113700 |
| alterations in serum thyroid hormonal indices with colestipol-niacin therapy. | a serial blood-lipid-lowering study at the university of southern california yielded unexpected findings on routine thyroid function monitoring. after 1 year of combined colestipol and niacin therapy, patients had reduced total serum thyroxine (t4) levels and increased triiodothyronine uptake ratios, an indicator of apparent decreases in thyroxine-binding globulin levels. calculation of the free t4 index partially but not completely corrected for the apparent decrease in thyroxine-binding globul ... | 1987 | 3113309 |
| the secretory activity of the tuberoinfundibular dopaminergic neurons is modulated by the thyroid status in the adult rat: consequence on prolactin secretion. | an influence of thyroid status on the secretory activity of hypothalamic dopaminergic neurons was observed in adult rats and its involvement in the regulation of prolactin (prl) secretion was examined. the secretory activity of the tuberoinfundibular dopaminergic (tida) neurons was evaluated by measurement of dopamine (da) biosynthesis in the neurons and da release into hypophysial portal blood. the accumulation of da and prl in the adenohypophysis as well as prl concentration in plasma were als ... | 1987 | 3112600 |
| mutations affecting translation of the bacteriophage t4 riib gene cloned in escherichia coli. | mutant ribosome binding sites of the bacteriophage t4 riib gene, resident on an 873 bp dna fragment, were cloned into a plasmid vector as in-frame fusions to a reporter gene, beta-galactosidase. the collection of mutations included changes in the region 5' to the shine/dalgarno sequence, a mutation of the shine/dalgarno sequence, the alternate initiation codons gug, aua and acg, and mutants in which several closely spaced initiation codons compete with each other on the same mrna. the results sh ... | 1987 | 3112515 |
| surface marker studies on activated peripheral blood lymphocytes in idiopathic dilated cardiomyopathy. | expression of interleukin 2 (il-2) receptor on peripheral blood lymphocytes after stimulation with concanavalin a (con a) or anti-t3 monoclonal antibody was analyzed in patients with dilated cardiomyopathy (dcm) in order to clarify the abnormalities of lymphocyte activation mechanism in dcm. the expression of il-2 receptor after the stimulation with either con a or anti-t3 monoclonal antibody was found to be reduced in the patients with dcm when the results were compared with those of controls. ... | 1987 | 3112402 |
| selective reduction of the okt 4 positive 4b4 positive subset during htlv iii infection in humans. | combinations of monoclonal antibodies defining the okt 4 positive lymphocyte subset in the peripheral blood of intravenous drug abusers suggest that the 4b4 positive helper inducer population is greatly reduced in subjects infected with htlv iii. no differences were seen instead using different antibodies directed against various epitopes of the t4 molecule. these results suggest that the multiple marker assay could be very useful to define immunological status during htlv iii infection in human ... | 1987 | 3112401 |
| identification and isolation of a t4+t8+ cell with high t3 expression in human thymus: a possible late intermediate in thymocyte differentiation. | by using sensitive three-color fluorescence flow cytometric techniques, we were able to identify a t4+t8+ thymocyte with high t3 surface density (t3h) representing 4 to 9% of thymocytes. to characterize the t3ht4+t8+ cell, thymic subpopulations with high t3 surface density (t3h) and lower t3 density (t3l/t3-) were compared with regard to t6 expression. the t3h subpopulation was characterized by lower numbers of t6+ cells and reduced levels of t6 antigen density, whereas the t3l/t3- population wa ... | 1987 | 3112221 |
| role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. | to investigate the role of thyroxine-binding globulin (tbg) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (t4) and triiodothyronine (t3) were carried out in eight subjects with familial dysalbuminemic hyperthyroxinemia (fdh), in four subjects with inherited tbg excess, and in 15 normals. in high-tbg subjects, the reduction of t4 and t3 plasma clearance rates (by 51% and 54%, respectively) was associated with normal daily pro ... | 1987 | 3112186 |
| [studies on the behavioral development of rats treated neonatally with l-thyroxine]. | the effect of l-thyroxine administration from 2 to 10 days of age (neo-t4) on the behavioral development was studied. serum t4 levels in neo-t4 rats showed a marked and dose-related decrease at 15 days of age and a less marked decrease at 62 days of age. the locomotor activity of the neo-t4 rats was higher at 13 approximately 19 days of age and tended to be lower at 62 days of age than in the controls. at 17 days of age, apomorphine (0.1 mg/kg, s.c.) induced a marked increase in the frequency of ... | 1987 | 3111957 |
| changes in thyroid function tests and sex hormone binding globulin associated with treatment by gonadotropin. | increasing levels of e2 in gonadotropin-treated women stimulated hepatic synthesis of shbg and tbg, and consequently increases in t4 concentration. nevertheless, unchanged fti and tsh suggested that a euthyroid state was maintained. the temporal patterns for the rise in serum concentrations of tbg and shbg during gonadotropin therapy suggest that the synthesis of these proteins by the liver has different sensitivities to e2. | 1987 | 3111894 |
| theophylline treatment in the neonate with apnea: effect on growth hormone, thyroid hormone and trh induced tsh secretion. | caffeine has been shown to markedly alter growth hormone (gh), thyroid stimulating hormone (tsh), and thyroid hormones in animal studies. similar studies in the human are lacking. to determine the effect of theophylline treatment on endocrine function in neonates with apnea, 10 infants were studied prospectively pretreatment, immediately following therapeutic blood levels of theophylline, at 2, 4, and 6 weeks thereafter and finally 2 weeks after discontinuation of theophylline. t4, free t4, t3, ... | 1987 | 3111805 |
| concentrations of iodothyronines in serum of patients with chronic renal failure and other nonthyroidal illnesses: role of free fatty acids. | the mean concentration of free thyroxin (ft4) in serum, as determined by direct equilibrium dialysis, was decreased in patients with chronic renal failure (crf) and increased in patients with various other nonthyroidal illnesses (nti). the mean concentration of dialyzable free triiodothyronine (ft3) in serum was equally low in both groups of patients. patients with crf of various etiology but a similar degree of renal failure as estimated from serum creatinine assay had very similar concentratio ... | 1987 | 3111749 |
| activation of autoreactive cytolytic t lymphocyte clone against human melanoma by anti-t3 monoclonal antibody and autologous accessory cells. | a cytotoxic t-lymphocyte (ctl) clone tc1.8 was derived in a limiting dilution culture from a single cell that was derived from melanoma-involved lymph node lymphocytes activated in in vitro coculture against the autologous melanoma cells (vip). the clone tc1.8 (t3+, t8+, t4-, and leu7-) expressed restricted cytolytic activity against only the autologous target vip. as it aged in continuous culture containing interleukin 2, tc1.8 lost cytolytic activity. the cytolytic function could be restored, ... | 1987 | 3111724 |
| trh-induced tsh and prolactin responses in the elderly. | since there are divergencies in the thyrotropin (tsh) response to thyrotropin-releasing hormone (trh) in old age, and since a hypothalamopituitary dysfunction has been suggested in the elderly, we have studied the thyroid function and the trh responsiveness of tsh and prolactin (prl) in 56 euthyroid patients over 70 years old, grouped according to age (70-79, 80-89, 90 or more years) and sex. results were compared to those of 15 postmenopausal women and 11 men. in the elderly patients there was ... | 1987 | 3111192 |
| diagnostic and prognostic value of monoclonal antibodies in immunophenotyping of t cell lymphomas. | 6 cases of post-thymic t cell lymphoma (ptcl) and 4 cases of t lymphoblastic lymphoma were investigated with a panel of 21 monoclonal antibodies (moab). the ptcl group was composed of 2 by 2 cases of lymphoepithelioid cell lymphoma, t zone lymphoma and t immunoblastic lymphoma. in lymphoepithelioid cell lymphoma, the cell proliferating activity was low, and a malignant clone was not identifiable by the methods used. in the cases of t zone lymphoma and t immunoblastic lymphoma, malignant populati ... | 1987 | 3111143 |
| systemic effects of 1,25-dihydroxyvitamin d3 on the pituitary-hypothalamic axis in rats. | treatment of rats with 1,25-dihydroxyvitamin d3 (1,25(oh)2d3) 0.05 microgram/kg per day for three days was without any effect on serum t3, t4 or tsh concentrations, whereas serum prl increased (20.6 +/- 3.8 to 76.2 +/- 19.1 micrograms/l, mean +/- sem, n = 7-8; p less than 0.01). increased hypothalamic trh levels (24.3 +/- 3.9 to 45.7 +/- 7.8 pmol/g wet weight; p less than 0.01) may indicate an effect of 1,25(oh)2d3 on hypothalamic trh homeostasis. this effect could probably be due to an indirect ... | 1987 | 3111137 |
| [gnrh-trh and arg-gnrh-trh test in females with normoprolactinemic galactorrhea]. | in 8 patients aged from 17 to 48 years (average age 32,6 years) with normoprolactinemic galactorrhea a stimulation test with gnrh-trh or arginine-gnrh-trh was performed. the basal and stimulated serum levels of lh, fsh, prl, tsh, hgh and total thyroxine (t4), the thyroxine binding capacity (tbc) and the free thyroxine index (ft4-i) were determined. -in a few cases there were disturbances of both the basal and the stimulated serum levels of the hormones. -both the menstrual disorders which were s ... | 1987 | 3111129 |
| [results of the gnrh-trh and arginine-gnrh-trh test in females with hyperprolactinemic galactorrhea]. | in 7 patients aged from 21 to 33 years (average age 24.6 years) with hyperprolactinemic galactorrhea a stimulation test with gnrh-trh or arginine-gnrh-trh was performed. the serum levels of lh, fsh, prl, hgh, tsh and total thyroxine (t4) were determined by ria, the thyroxine binding capacity (tbc) by radio agent assay. the free thyroxine index (ft4-i) was calculated. an adenoma of the pituitary gland was diagnosed in 3 patients by x-ray of sella turcica. in all patients there were disturbances o ... | 1987 | 3111128 |
| clinical and immunological restoration in patients with aids after marrow transplantation, using lymphocyte transfusions from the marrow donor. | the diagnosis of transfusion-associated acquired immunodeficiency syndrome (aids) was made in 2 patients who developed delayed opportunistic infections and severe cytopenias--56 months for the former (patient 1) and 22 months for the latter, (patient 2) following bone marrow transplantation (bmt) for aplastic anemia. in the third case, grafting for acute leukemia (patient 3) (hiv) infection was probably responsible for the failure of hematological and immunological reconstitution 8 months after ... | 1987 | 3111037 |
| changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. | in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) and related compounds, serum thyroxine (t4) is depressed. since hamsters are relatively insensitive to tcdd-induced lethality, the effects of tcdd on several parameters of thyroid status were measured in hamsters as a comparison with the more sensitive rat. at 7 days after ip injection of tcdd, there was a dose-dependent increase in serum 3,5,3'-triiodothyronine (t3) and t4 in hamsters to a maximum level 200% of control; the ed50 was ... | 1987 | 3111013 |